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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACCSL Gene

protein-coding   GIFtS: 36
GCID: GC11P044027

1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Arabidopsis)(Non-Functional)-Like

  Search for ACCSL
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
1-Aminocyclopropane-1-Carboxylate Synthase Homolog
(Arabidopsis)(Non-Functional)-Like1 2
ACC Synthase-Like Protein 22 3
1-Aminocyclopropane-1-Carboxylate Synthase-Like Protein 22
Probable Inactive 1-Aminocyclopropane-1-Carboxylate Synthase-Like Protein
22

External Ids:    HGNC: 343911   Entrez Gene: 3901102   Ensembl: ENSG000002051267   UniProtKB: Q4AC993   

Export aliases for ACCSL gene to outside databases

Previous GC identifer: GC11P043778


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ACCSL Gene: 
ACCSL (1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like) is a protein-coding gene. GO annotations related to this gene include pyridoxal phosphate binding and catalytic activity. An important paralog of this gene is ACCS.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACCSL gene promoter:
         STAT1   STAT4   STAT1beta   STAT6   STAT5A   STAT1alpha   Ik-2   HOXA5   STAT2   STAT3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ACCSL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACCSL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

ACCSL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACCSL gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P044027:  view genomic region     (about GC identifiers)

Start:
44,069,531 bp from pter      End:
44,081,527 bp from pter
Size:
11,997 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: 1A1L2_HUMAN, Q4AC99 (See protein sequence)
Recommended Name: Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2  
Size: 568 amino acids; 65249 Da
Caution: While belonging to the class-I pyridoxal-phosphate-dependent aminotransferase family, it lacks a number
of residues which are necessary for activity thus suggesting that it lacks enzymatic activity

Explore the universe of human proteins at neXtProt for ACCSL: NX_Q4AC99

Explore proteomics data for ACCSL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q4AC99

  • ACCSL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ACCSL Protein Expression
    REFSEQ proteins: NP_001027025.2  
    ENSEMBL proteins: 
     ENSP00000368109   ENSP00000436505  

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    Cloud-Clone Corp. CLIAs for ACCSL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR004839 Aminotransferase_I/II
     IPR015424 PyrdxlP-dep_Trfase
     IPR015421 PyrdxlP-dep_Trfase_major_sub1
     IPR015422 PyrdxlP-dep_Trfase_major_sub2

    Graphical View of Domain Structure for InterPro Entry Q4AC99

    ProtoNet protein and cluster: Q4AC99

    UniProtKB/Swiss-Prot: 1A1L2_HUMAN, Q4AC99
    Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family


    ACCSL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity IEA--
    GO:0030170pyridoxal phosphate binding IEA--
         
    ACCSL for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACCSL

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009058biosynthetic process IEA--

    ACCSL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACCSL (1A1L2)

    Search CenterWatch for drugs/clinical trials and news about ACCSL / 1A1L2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for ACCSL gene: 
    NM_001031854.2  

    Unigene Cluster for ACCSL:

    1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like
    Hs.558851  [show with all ESTs]
    Unigene Representative Sequence: NM_001031854
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378832(uc001mxw.1 uc009ykr.2) ENST00000527145
    miRNA
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    Additional mRNA sequence: 

    AB231732.1 AB231733.1 AB231734.1 BC144554.1 

    1 DOTS entry:

    DT.120683219 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACCSL expression in normal human tissues (normalized intensities)      ACCSL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATCTGGGG
    ACCSL Expression
    About this image


    ACCSL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)
             oocyte   
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer

    See ACCSL Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.558851
        SABiosciences Custom PCR Arrays for ACCSL
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACCSL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACCSL gene from 7/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Accsl1 , 5 1-aminocyclopropane-1-carboxylate synthase homolog more5
    1-aminocyclopropane-1-carboxylate synthase (non-functional)-like1
    71.44(n)1
    59.54(a)1
      2 (51.62 cM)5
    3814111  NM_001033452.31  NP_001028624.21 
     938553615 
    chicken
    (Gallus gallus)
    Aves --
    --
    Uncharacterized protein
    46(a)
    43(a)
    1 ↔ many
    possible ortholog
    5(21006095-21019310)
    2(22758020-22774675)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    48(a)
    43(a)
    1 ↔ many
    possible ortholog
    1(45535229-45561979)
    6(21231512-21253271)
    zebrafish
    (Danio rerio)
    Actinopterygii accs6
    1-aminocyclopropane-1-carboxylate synthase homolog...
    24(a)
    1 → many
    25(9149694-9177908)
    worm
    (Caenorhabditis elegans)
    Secernentea T04F3.16
    Protein T04F3.1, isoform a
    3(a)
    1 → many
    V(11740230-11754199)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ACS21 1-aminocyclopropane-1-carboxylate synthase 2 45.67(n)
    33.33(a)
      837082  NM_100030.3  NP_171655.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g05780001 hypothetical protein 46.17(n)
    31.72(a)
      4336750  NM_001060172.1  NP_001053637.1 


    ENSEMBL Gene Tree for ACCSL (if available)
    TreeFam Gene Tree for ACCSL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACCSL gene
    ACCS2  
    1 SIMAP similar gene for ACCSL using alignment to 2 protein entries:     1A1L2_HUMAN (see all proteins):
    ACCS

    ACCSL for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ACCSL
    PGOHUM00000243055


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/362 SNPs in ACCSL are shown (see all 362)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1461496361,2
    --44067538(+) CACTCC/TGCAGG 1 -- us2k10--------
    rs790913281,2
    F--44067619(+) CTCTAT/CGATAA 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1835114171,2
    --44067740(+) AGAGAC/TGGTTT 1 -- us2k10--------
    rs1162070851,2
    F--44067840(+) TTGGGA/TTCGTA 1 -- us2k11Minor allele frequency- T:0.08WA 118
    rs1885041681,2
    --44067970(+) TGCCTC/TTCCTA 1 -- us2k10--------
    rs1401975011,2
    --44068107(+) AATGGA/GAACAT 1 -- us2k10--------
    rs1929108761,2
    --44068206(+) CGAGGC/TTTTTT 1 -- us2k10--------
    rs1439266291,2
    --44068213(+) TTTTTG/TTGTGT 1 -- us2k10--------
    rs1390904821,2
    C--44068239(+) GGATG-/TTTACT 1 -- us2k10--------
    rs1404519431,2
    --44068510(+) TGCAGG/TAAGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ACCSL (44069531 - 44081527 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ACCSL:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv510251CNV Loss20534489

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ACCSL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACCSL gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ACCSL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    3. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 390110 HGNC: 34391 Ensembl:ENSG00000205126 euGenes: HUgn390110 ECgene: ACCSL
    H-InvDB: ACCSL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACCSL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ACCSL gene:
    Search GeneIP for patents involving ACCSL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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