Aliases for ACCSL Gene
Aliases for ACCSL Gene
External Ids for ACCSL Gene
- HGNC: 34391
- Entrez Gene: 390110
- Ensembl: ENSG00000205126
- UniProtKB: Q4AC99
Previous GeneCards Identifiers for ACCSL Gene
- GC11P044027
- GC11P043778
Summaries for ACCSL Gene
GeneCards Summary for ACCSL Gene
ACCSL (1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Inactive) Like) is a Protein Coding gene. GO annotations related to this gene include pyridoxal phosphate binding. An important paralog of this gene is ACCS.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACCSL Gene
Genomics for ACCSL Gene
Regulatory Elements for ACCSL Gene
Enhancers for ACCSL Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH11G043920 | 1.6 | Ensembl ENCODE dbSUPER | 0.7 | +2.5 | 2477 | 12.1 | HDGF FOXA2 PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A FEZF1 ZNF2 | ALKBH3 API5 ALKBH3-AS1 ACCSL C11orf96 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ACCSL on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ACCSL gene promoter:
Regulatory Element Products
Genomic Location for ACCSL Gene
- Chromosome:
- 11
- Start:
- 43,921,084 bp from pter
- End:
- 44,060,307 bp from pter
- Size:
- 139,224 bases
- Orientation:
- Plus strand
Genomic View for ACCSL Gene
Genes around ACCSL on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p11.2 by Ensembl
- 11p11.2 by Entrez Gene
- 11p11.2 by HGNC
ACCSL Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ACCSL Gene
Proteins for ACCSL Gene
-
Protein details for ACCSL Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q4AC99-1A1L2_HUMAN
- Recommended name:
- Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2
- Protein Accession:
- Q4AC99
Protein attributes for ACCSL Gene
- Size:
- 568 amino acids
- Molecular mass:
- 65249 Da
- Quaternary structure:
- No Data Available
Protein Expression for ACCSL Gene
Post-translational modifications for ACCSL Gene
Other Protein References for ACCSL Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ACCSL
- Novus Biologicals Antibodies for ACCSL
- Invitrogen Antibodies for ACCSL
- GeneTex ACCSL antibody for ACCSL
Protein Products
-
OriGene Purified Proteins for ACCSL
- Search Origene for MassSpec and Protein Over-expression Lysates for ACCSL
- Origene Custom Protein Services for ACCSL
- Search GeneTex for Proteins for ACCSL
Assay Products
No data available for DME Specific Peptides for ACCSL Gene
Domains & Families for ACCSL Gene
Protein Domains for ACCSL Gene
Suggested Antigen Peptide Sequences for ACCSL Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q4AC99UniProtKB/Swiss-Prot:
1A1L2_HUMAN :- Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
- Family:
-
- Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
No data available for Gene Families for ACCSL Gene
Function for ACCSL Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0030170 | pyridoxal phosphate binding | IEA | -- |
Phenotypes for ACCSL Gene
- GenomeRNAi human phenotypes for ACCSL:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ACCSL
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ACCSL gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ACCSL gene
- Search ViGene Biosciences for ACCSL
CRISPR Products
-
OriGene CRISPR knockouts for ACCSL
-
Santa Cruz Biotechnology (SCBT) CRISPR for ACCSL
- GenScript: Design CRISPR guide RNA sequences for ACCSL
miRNA Products
- Search ViGene Biosciences for ACCSL
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for ACCSL
- Browse OriGene Inhibitory RNA Products For ACCSL
-
ViGene Biosciences ready-to-package AAV shRNAs for ACCSL gene
Clone Products
-
OriGene ORF clones in human for ACCSL
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for ACCSL
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ACCSL
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ACCSL
-
ViGene Biosciences adenoviral particle packaged cDNA for ACCSL gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ACCSL gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ACCSL gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACCSL Gene
Localization for ACCSL Gene
| Compartment | Confidence |
|---|---|
| cytosol | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ACCSL Gene
Pathways & Interactions for ACCSL Gene
No Data Available
Interacting Proteins for ACCSL Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0009058 | biosynthetic process | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ACCSL Gene
Transcripts for ACCSL Gene
mRNA/cDNA for ACCSL Gene
- (3) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ACCSL Gene
- 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ACCSL
-
Santa Cruz Biotechnology (SCBT) CRISPR for ACCSL
- GenScript: Design CRISPR guide RNA sequences for ACCSL
miRNA Products
- Search ViGene Biosciences for ACCSL
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for ACCSL
- Browse OriGene Inhibitory RNA Products For ACCSL
-
ViGene Biosciences ready-to-package AAV shRNAs for ACCSL gene
Clone Products
-
OriGene ORF clones in human for ACCSL
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for ACCSL
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ACCSL
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for ACCSL Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Eye (Sensory Organs)
- nGnG Amacrine Cells Inner Nuclear Layer
-
Neurons
- nGnG Amacrine Cells Inner Nuclear Layer
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for ACCSL Gene
This gene is overexpressed in Testis (x13.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ACCSL Gene
NURSA nuclear receptor signaling pathways regulating expression of ACCSL Gene:
ACCSLSOURCE GeneReport for Unigene cluster for ACCSL Gene:
Hs.558851Primer Products
-
OriGene qPCR primer pairs for ACCSL
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACCSL Gene
Orthologs for ACCSL Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ACCSL 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ACCSL 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Accsl 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Accsl 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ACCSL 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ACCSL 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 35 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | accs 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | T04F3.1 35 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | ACS2 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os04g0578000 34 |
|
- Species where no ortholog for ACCSL was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for ACCSL Gene
(1) SIMAP similar genes for ACCSL Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for ACCSL Gene
Variants for ACCSL Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000021892 | -- | 44,020,252(+) | TATAT(A/G)TAAGA | intron-variant | |
| rs1000031004 | -- | 44,007,919(+) | CTCCT(-/A)AAACA | intron-variant | |
| rs1000034707 | -- | 43,927,272(+) | TAGAT(A/G)GTGGT | intron-variant | |
| rs1000042761 | -- | 43,982,532(+) | CTTTT(C/T)TCACA | intron-variant | |
| rs1000043997 | -- | 44,048,836(+) | TTAGC(A/G)TAGTG | intron-variant |
Residual Variation Intolerance Score:
57.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.78;
33.55% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ACCSL Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACCSL Gene
Disorders for ACCSL Gene
Relevant External Links for ACCSL
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ACCSL
No disorders were found for ACCSL Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACCSL Gene
Publications for ACCSL Gene
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
Products for ACCSL Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for ACCSL
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ACCSL
- Search Origene for MassSpec and Protein Over-expression Lysates for ACCSL
- Origene Custom Protein Services for ACCSL
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ACCSL
- Browse OriGene Inhibitory RNA Products For ACCSL
- OriGene qPCR primer pairs for ACCSL
- OriGene CRISPR knockouts for ACCSL
- OriGene ORF clones in human for ACCSL
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ACCSL
- GenScript: Next-day shipping cDNA ORF clone for ACCSL in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ACCSL
- GenScript Custom Assay Services for ACCSL
- GenScript Custom overexpressing Cell Line Services for ACCSL
- GenScript: Design CRISPR guide RNA sequences for ACCSL
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ACCSL
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for ACCSL
- Novus Biologicals proteins and lysates for ACCSL
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Invitrogen Antibodies for ACCSL
- ViGene Biosciences adenoviral particle packaged cDNA for ACCSL gene
- ViGene Biosciences lentiviral particle packaged cDNA for ACCSL gene
- ViGene Biosciences ready-to-package AAV shRNAs for ACCSL gene
- Search ViGene Biosciences for ACCSL
- Horizon Cell Lines for ACCSL
- Cyagen custom Knockout/knockin (KOKI) mouse models for ACCSL
- VectorBuilder custom plasmid, inducible vectors for ACCSL
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ACCSL
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ACCSL Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer