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Aliases for ACCSL Gene

Aliases for ACCSL Gene

  • 1-Aminocyclopropane-1-Carboxylate Synthase (Inactive)-Like 2 3 5
  • 1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Arabidopsis)(Non-Functional)-Like 2
  • ACC Synthase-Like Protein 2 4

External Ids for ACCSL Gene

Previous GeneCards Identifiers for ACCSL Gene

  • GC11P044027
  • GC11P043778

Summaries for ACCSL Gene

GeneCards Summary for ACCSL Gene

ACCSL (1-Aminocyclopropane-1-Carboxylate Synthase (Inactive)-Like) is a Protein Coding gene. GO annotations related to this gene include pyridoxal phosphate binding. An important paralog of this gene is ACCS.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACCSL Gene

Genomics for ACCSL Gene

Regulatory Elements for ACCSL Gene

Enhancers for ACCSL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ACCSL on UCSC Golden Path with GeneCards custom track

Genomic Location for ACCSL Gene

43,921,084 bp from pter
44,060,307 bp from pter
139,224 bases
Plus strand

Genomic View for ACCSL Gene

Genes around ACCSL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACCSL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACCSL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACCSL Gene

Proteins for ACCSL Gene

  • Protein details for ACCSL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2
    Protein Accession:

    Protein attributes for ACCSL Gene

    568 amino acids
    Molecular mass:
    65249 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ACCSL Gene

Proteomics data for ACCSL Gene at MOPED

Post-translational modifications for ACCSL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACCSL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACCSL Gene

Domains & Families for ACCSL Gene

Suggested Antigen Peptide Sequences for ACCSL Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
genes like me logo Genes that share domains with ACCSL: view

No data available for Gene Families for ACCSL Gene

Function for ACCSL Gene

Gene Ontology (GO) - Molecular Function for ACCSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
genes like me logo Genes that share ontologies with ACCSL: view

Phenotypes for ACCSL Gene

GenomeRNAi human phenotypes for ACCSL:
genes like me logo Genes that share phenotypes with ACCSL: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACCSL Gene

Localization for ACCSL Gene

Subcellular locations from

Jensen Localization Image for ACCSL Gene COMPARTMENTS Subcellular localization image for ACCSL gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ACCSL Gene

Pathways & Interactions for ACCSL Gene

SuperPathways for ACCSL Gene

No Data Available

Interacting Proteins for ACCSL Gene

Gene Ontology (GO) - Biological Process for ACCSL Gene


No data available for Pathways by source and SIGNOR curated interactions for ACCSL Gene

Drugs & Compounds for ACCSL Gene

No Compound Related Data Available

Transcripts for ACCSL Gene

mRNA/cDNA for ACCSL Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACCSL Gene

1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACCSL Gene

No ASD Table

Relevant External Links for ACCSL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACCSL Gene

mRNA expression in normal human tissues for ACCSL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACCSL Gene

This gene is overexpressed in Testis (x13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ACCSL Gene

SOURCE GeneReport for Unigene cluster for ACCSL Gene Hs.558851

genes like me logo Genes that share expression patterns with ACCSL: view

Primer Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ACCSL Gene

Orthologs for ACCSL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACCSL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ACCSL 35
  • 79.2 (n)
  • 67.63 (a)
  • 63 (a)
(Mus musculus)
Mammalia Accsl 35
  • 70.86 (n)
  • 59.24 (a)
Accsl 16
Accsl 36
  • 54 (a)
(Pan troglodytes)
Mammalia ACCSL 35
  • 99.18 (n)
  • 98.06 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Accsl 35
  • 70.71 (n)
  • 58.11 (a)
(Monodelphis domestica)
Mammalia ACCSL 36
  • 33 (a)
(Ornithorhynchus anatinus)
Mammalia ACCSL 36
  • 60 (a)
(Gallus gallus)
Aves -- 36
  • 46 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
(Danio rerio)
Actinopterygii accs 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea T04F3.1 36
  • 4 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ACS2 35
  • 45.59 (n)
  • 33.33 (a)
(Oryza sativa)
Liliopsida Os04g0578000 35
  • 46.25 (n)
  • 31.72 (a)
Species with no ortholog for ACCSL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ACCSL Gene

Gene Tree for ACCSL (if available)
Gene Tree for ACCSL (if available)

Paralogs for ACCSL Gene

Paralogs for ACCSL Gene

(1) SIMAP similar genes for ACCSL Gene using alignment to 2 proteins: Pseudogenes for ACCSL Gene

genes like me logo Genes that share paralogs with ACCSL: view

Variants for ACCSL Gene

Sequence variations from dbSNP and Humsavar for ACCSL Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2074051 - 44,058,660(+) GGTTC(C/T)GCCTC reference, missense
rs546614 -- 43,962,423(+) GATGA(A/C)GTTCG intron-variant
rs598097 -- 43,956,341(+) gaggc(A/T)gcttt intron-variant
rs630211 -- 43,958,890(+) tattt(G/T)ggttt intron-variant
rs657088 -- 43,960,307(+) ttttt(C/T)cttta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACCSL Gene

Variant ID Type Subtype PubMed ID
nsv510251 CNV Loss 20534489

Variation tolerance for ACCSL Gene

Residual Variation Intolerance Score: 57.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACCSL Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACCSL Gene

Disorders for ACCSL Gene

Relevant External Links for ACCSL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ACCSL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACCSL Gene

Publications for ACCSL Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ACCSL Gene

Sources for ACCSL Gene