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Aliases for ACCS Gene

Aliases for ACCS Gene

  • 1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Inactive) 2 3 5
  • ACC Synthase-Like Protein 1 3 4
  • PHACS 3 4
  • 1-Aminocyclopropane-1-Carboxylate Synthase-Like Protein (Non-Functional) Isoform 1 3
  • 1-Aminocyclopropane-1-Carboxylate Synthase-Like Protein (Non-Functional) Isoform 2 3
  • 1-Aminocyclopropane-1-Carboxylate Synthase-Like Protein (Non-Functional) Isoform 4 3
  • 1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Arabidopsis)(Non-Functional) 2
  • ACS 3

External Ids for ACCS Gene

Previous GeneCards Identifiers for ACCS Gene

  • GC11P043796

Summaries for ACCS Gene

GeneCards Summary for ACCS Gene

ACCS (1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Inactive)) is a Protein Coding gene. Diseases associated with ACCS include Neonatal Anemia and Twin-To-Twin Transfusion Syndrome. GO annotations related to this gene include protein homodimerization activity and 1-aminocyclopropane-1-carboxylate synthase activity. An important paralog of this gene is ACCSL.

UniProtKB/Swiss-Prot for ACCS Gene

  • Does not catalyze the synthesis of 1-aminocyclopropane-1-carboxylate but is capable of catalyzing the deamination of L-vinylglycine.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACCS Gene

Genomics for ACCS Gene

Regulatory Elements for ACCS Gene

Enhancers for ACCS Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ACCS on UCSC Golden Path with GeneCards custom track

Promoters for ACCS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ACCS on UCSC Golden Path with GeneCards custom track

Genomic Location for ACCS Gene

44,065,925 bp from pter
44,084,237 bp from pter
18,313 bases
Plus strand

Genomic View for ACCS Gene

Genes around ACCS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACCS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACCS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACCS Gene

Proteins for ACCS Gene

  • Protein details for ACCS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    1-aminocyclopropane-1-carboxylate synthase-like protein 1
    Protein Accession:
    Secondary Accessions:
    • B4E219
    • Q8WUL4
    • Q96LX5

    Protein attributes for ACCS Gene

    501 amino acids
    Molecular mass:
    57324 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ACCS Gene


neXtProt entry for ACCS Gene

Proteomics data for ACCS Gene at MOPED

Post-translational modifications for ACCS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACCS Gene

No data available for DME Specific Peptides for ACCS Gene

Domains & Families for ACCS Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
genes like me logo Genes that share domains with ACCS: view

No data available for Gene Families for ACCS Gene

Function for ACCS Gene

Molecular function for ACCS Gene

UniProtKB/Swiss-Prot Function:
Does not catalyze the synthesis of 1-aminocyclopropane-1-carboxylate but is capable of catalyzing the deamination of L-vinylglycine.

Gene Ontology (GO) - Molecular Function for ACCS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016847 NOT 1-aminocyclopropane-1-carboxylate synthase activity IDA 11470512
GO:0042803 protein homodimerization activity NAS 11470512
genes like me logo Genes that share ontologies with ACCS: view
genes like me logo Genes that share phenotypes with ACCS: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACCS Gene

Localization for ACCS Gene

Subcellular locations from

Jensen Localization Image for ACCS Gene COMPARTMENTS Subcellular localization image for ACCS gene
Compartment Confidence
cytosol 3
golgi apparatus 2
nucleus 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ACCS Gene

Pathways & Interactions for ACCS Gene

SuperPathways for ACCS Gene

No Data Available

Gene Ontology (GO) - Biological Process for ACCS Gene


No data available for Pathways by source and SIGNOR curated interactions for ACCS Gene

Drugs & Compounds for ACCS Gene

(6) Drugs for ACCS Gene - From: DrugBank, ClinicalTrials, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vinylglycine Experimental Pharma Target 0
Pharmaceutical Solutions Pharma 7317
Cola Nutra 1794

(6) Additional Compounds for ACCS Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ACCS: view

Transcripts for ACCS Gene

Unigene Clusters for ACCS Gene

1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACCS Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP6: - -
SP7: - - -

Relevant External Links for ACCS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACCS Gene

mRNA expression in normal human tissues for ACCS Gene

Protein differential expression in normal tissues from HIPED for ACCS Gene

This gene is overexpressed in Adipocyte (42.5), Skin (20.3), and CD4 Tcells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACCS Gene

SOURCE GeneReport for Unigene cluster for ACCS Gene Hs.126706

genes like me logo Genes that share expression patterns with ACCS: view

Protein tissue co-expression partners for ACCS Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ACCS Gene

Orthologs for ACCS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACCS Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ACCS 35
  • 86.89 (n)
  • 83.43 (a)
ACS 36
  • 75 (a)
(Canis familiaris)
Mammalia ACCS 35
  • 88.04 (n)
  • 84.17 (a)
  • 76 (a)
(Mus musculus)
Mammalia Accs 35
  • 84.24 (n)
  • 84.31 (a)
Accs 16
Accs 36
  • 84 (a)
(Pan troglodytes)
Mammalia ACCS 35
  • 99.27 (n)
  • 99 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Accs 35
  • 85.96 (n)
  • 83.62 (a)
(Monodelphis domestica)
Mammalia ACCS 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia ACCS 36
  • 71 (a)
(Gallus gallus)
Aves ACCS 35
  • 67.02 (n)
  • 65.39 (a)
-- 36
  • 56 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia accs 35
  • 66.13 (n)
  • 62.82 (a)
Str.4277 35
(Danio rerio)
Actinopterygii accs 35
  • 60.7 (n)
  • 59.77 (a)
accs 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea T04F3.1 36
  • 4 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ACS9 35
  • 45.9 (n)
  • 34.87 (a)
(Oryza sativa)
Liliopsida Os03g0727600 35
  • 47.53 (n)
  • 33.93 (a)
Species with no ortholog for ACCS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACCS Gene

Gene Tree for ACCS (if available)
Gene Tree for ACCS (if available)

Paralogs for ACCS Gene

Paralogs for ACCS Gene

(1) SIMAP similar genes for ACCS Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ACCS: view

Variants for ACCS Gene

Sequence variations from dbSNP and Humsavar for ACCS Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs35514614 A breast cancer sample 44,077,852(-) CTAGC(C/T)CAGTG nc-transcript-variant, reference, missense, utr-variant-5-prime
VAR_038686 A breast cancer sample
rs3107275 - 44,083,431(+) CCTGC(C/T)CAAGG intron-variant, nc-transcript-variant, downstream-variant-500B, reference, missense
rs33952257 - 44,067,802(+) CCTCT(A/G)ATACC nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs2018795 - 44,073,500(+) GCTGA(C/G)TGGAG intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ACCS Gene

Variant ID Type Subtype PubMed ID
nsv832139 CNV Loss 17160897
nsv523327 CNV Gain 19592680
esv995967 CNV Insertion 20482838

Variation tolerance for ACCS Gene

Residual Variation Intolerance Score: 83.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.92; 93.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACCS Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACCS Gene

Disorders for ACCS Gene

MalaCards: The human disease database

(2) MalaCards diseases for ACCS Gene - From: DISEASES

Disorder Aliases PubMed IDs
neonatal anemia
  • anemia neonatal
twin-to-twin transfusion syndrome
  • twin twin transfusion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ACCS in MalaCards View complete list of genes associated with diseases

Relevant External Links for ACCS

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ACCS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACCS Gene

Publications for ACCS Gene

  1. The human cDNA for a homologue of the plant enzyme 1- aminocyclopropane-1-carboxylate synthase encodes a protein lacking that activity. (PMID: 11470512) Koch K.A. … Kirsch J.F. (Gene 2001) 2 3 4 23 67
  2. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu C.Y. … Christiani D.C. (Carcinogenesis 2010) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ACCS Gene

Sources for ACCS Gene