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Aliases for ACCS Gene

Aliases for ACCS Gene

  • 1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Arabidopsis)(Non-Functional) 2 3
  • PHACS 3 4 6
  • ACC Synthase-Like Protein 1 3 4
  • ACS 3 6
  • 1-Aminocyclopropane-1-Carboxylate Synthase-Like Protein 1 3

External Ids for ACCS Gene

Summaries for ACCS Gene

GeneCards Summary for ACCS Gene

ACCS (1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Arabidopsis)(Non-Functional)) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and 1-aminocyclopropane-1-carboxylate synthase activity. An important paralog of this gene is ACCSL.

UniProtKB/Swiss-Prot for ACCS Gene

  • Does not catalyze the synthesis of 1-aminocyclopropane-1-carboxylate but is capable of catalyzing the deamination of L-vinylglycine.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACCS Gene

Genomics for ACCS Gene

Genomic Location for ACCS Gene

Start:
44,065,925 bp from pter
End:
44,084,240 bp from pter
Size:
18,316 bases
Orientation:
Plus strand

Genomic View for ACCS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACCS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACCS Gene

Regulatory Elements for ACCS Gene

Proteins for ACCS Gene

  • Protein details for ACCS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QU6-1A1L1_HUMAN
    Recommended name:
    1-aminocyclopropane-1-carboxylate synthase-like protein 1
    Protein Accession:
    Q96QU6
    Secondary Accessions:
    • B4E219
    • Q8WUL4
    • Q96LX5

    Protein attributes for ACCS Gene

    Size:
    501 amino acids
    Molecular mass:
    57324 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ACCS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACCS Gene

Proteomics data for ACCS Gene at MOPED

Post-translational modifications for ACCS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACCS Gene

No data available for DME Specific Peptides for ACCS Gene

Domains for ACCS Gene

UniProtKB/Swiss-Prot:

1A1L1_HUMAN
Family:
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.:
    • Q96QU6
genes like me logo Genes that share domains with ACCS: view

No data available for Gene Families for ACCS Gene

Function for ACCS Gene

Molecular function for ACCS Gene

UniProtKB/Swiss-Prot Function: Does not catalyze the synthesis of 1-aminocyclopropane-1-carboxylate but is capable of catalyzing the deamination of L-vinylglycine.

Gene Ontology (GO) - Molecular Function for ACCS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016847 NOT 1-aminocyclopropane-1-carboxylate synthase activity IDA 11470512
GO:0030170 pyridoxal phosphate binding NAS 11470512
GO:0042803 protein homodimerization activity NAS 11470512
genes like me logo Genes that share ontologies with ACCS: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ACCS Gene

Localization for ACCS Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACCS Gene COMPARTMENTS Subcellular localization image for ACCS gene
Compartment Confidence
cytosol 3
nucleus 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ACCS Gene

Pathways for ACCS Gene

SuperPathways for ACCS Gene

No Data Available

Gene Ontology (GO) - Biological Process for ACCS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009058 biosynthetic process IEA --
genes like me logo Genes that share ontologies with ACCS: view

No data available for Pathways by source for ACCS Gene

Compounds for ACCS Gene

(1) Drugbank Compounds for ACCS Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Vinylglycine
  • (2s)-2-Amino-3-Butenoic Acid
52773-87-2 target

(9) Novoseek inferred chemical compound relationships for ACCS Gene

Compound -log(P) Hits PubMed IDs
l-vinylglycine 96.8 1
1-aminocyclopropane-1-carboxylate 95.9 26
histidinol-phosphate 88 1
ethylene 77.9 10
pyridoxal 5-phosphate 74.3 3
genes like me logo Genes that share compounds with ACCS: view

Transcripts for ACCS Gene

Unigene Clusters for ACCS Gene

1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACCS Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6: - -
SP7: - - -
SP8:

Relevant External Links for ACCS Gene

GeneLoc Exon Structure for
ACCS
ECgene alternative splicing isoforms for
ACCS

Expression for ACCS Gene

mRNA expression in normal human tissues for ACCS Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACCS Gene

SOURCE GeneReport for Unigene cluster for ACCS Gene Hs.126706

genes like me logo Genes that share expressions with ACCS: view

Orthologs for ACCS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACCS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACCS 36
  • 99.27 (n)
  • 99 (a)
ACCS 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACCS 36
  • 86.89 (n)
  • 83.43 (a)
ACS 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACCS 36
  • 88.04 (n)
  • 84.17 (a)
ACCS 37
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Accs 36
  • 84.24 (n)
  • 84.31 (a)
Accs 16
Accs 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACCS 37
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACCS 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Accs 36
  • 85.96 (n)
  • 83.62 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 56 (a)
OneToMany
ACCS 36
  • 67.02 (n)
  • 65.39 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 58 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia accs 36
  • 66.13 (n)
  • 62.82 (a)
Str.4277 36
zebrafish
(Danio rerio)
Actinopterygii accs 36
  • 60.7 (n)
  • 59.77 (a)
accs 37
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T04F3.1 37
  • 4 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ACS9 36
  • 45.9 (n)
  • 34.87 (a)
rice
(Oryza sativa)
Liliopsida Os03g0727600 36
  • 47.53 (n)
  • 33.93 (a)
Species with no ortholog for ACCS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACCS Gene

ENSEMBL:
Gene Tree for ACCS (if available)
TreeFam:
Gene Tree for ACCS (if available)

Paralogs for ACCS Gene

Paralogs for ACCS Gene

Selected SIMAP similar genes for ACCS Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ACCS: view

Variants for ACCS Gene

Sequence variations from dbSNP and Humsavar for ACCS Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs113080 -- 44,080,257(+) ATGTG(G/T)GTAGT intron-variant
rs178509 -- 44,065,214(+) gggcc(A/G)ccaca upstream-variant-2KB
rs178510 -- 44,065,633(+) agtca(A/C)ctctt upstream-variant-2KB
rs178511 -- 44,065,685(+) aaata(C/T)acatg upstream-variant-2KB
rs178512 -- 44,065,761(+) aagaa(A/C)ctatg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ACCS Gene

Variant ID Type Subtype PubMed ID
nsv832139 CNV Loss 17160897
nsv523327 CNV Gain 19592680
esv995967 CNV Insertion 20482838

Relevant External Links for ACCS Gene

HapMap Linkage Disequilibrium report
ACCS
Human Gene Mutation Database (HGMD)
ACCS

Disorders for ACCS Gene

(1) University of Copenhagen DISEASES for ACCS Gene

Relevant External Links for ACCS

Genetic Association Database (GAD)
ACCS
Human Genome Epidemiology (HuGE) Navigator
ACCS
genes like me logo Genes that share disorders with ACCS: view

No data available for UniProtKB/Swiss-Prot for ACCS Gene

Publications for ACCS Gene

  1. The human cDNA for a homologue of the plant enzyme 1- aminocyclopropane-1-carboxylate synthase encodes a protein lacking that activity. (PMID: 11470512) Koch K.A. … Kirsch J.F. (Gene 2001) 2 3 4 23
  2. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu C.Y. … Christiani D.C. (Carcinogenesis 2010) 3 49
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ACCS Gene

Sources for ACCS Gene

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