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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACCS Gene

protein-coding   GIFtS: 55
GCID: GC11P044045

1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Arabidopsis)(Non-Functional)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
1-Aminocyclopropane-1-Carboxylate Synthase Homolog
(Arabidopsis)(Non-Functional)1 2
PHACS2 3 5
ACC Synthase-Like Protein 12 3
ACS2 5
1-Aminocyclopropane-1-Carboxylate Synthase-Like Protein 12

External Ids:    HGNC: 239891   Entrez Gene: 846802   Ensembl: ENSG000001104557   OMIM: 6084055   UniProtKB: Q96QU63   

Export aliases for ACCS gene to outside databases

Previous GC identifer: GC11P043796


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ACCS Gene: 
ACCS (1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)) is a protein-coding gene. Diseases associated with ACCS include lung adenoid cystic carcinoma, and cutaneous adenocystic carcinoma. GO annotations related to this gene include 1-aminocyclopropane-1-carboxylate synthase activity and protein homodimerization activity. An important paralog of this gene is ACCSL.

UniProtKB/Swiss-Prot: 1A1L1_HUMAN, Q96QU6
Function: Does not catalyze the synthesis of 1-aminocyclopropane-1-carboxylate but is capable of catalyzing the
deamination of L-vinylglycine




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACCS gene promoter:
         AhR   Elk-1   AML1a   STAT3   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACCS promoter sequence
   Search SABiosciences Chromatin IP Primers for ACCS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACCS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11

ACCS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACCS gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P044045:  view genomic region     (about GC identifiers)

Start:
44,087,475 bp from pter      End:
44,105,772 bp from pter
Size:
18,298 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: 1A1L1_HUMAN, Q96QU6 (See protein sequence)
Recommended Name: 1-aminocyclopropane-1-carboxylate synthase-like protein 1  
Size: 501 amino acids; 57324 Da
Caution: Similar to plant 1-aminocyclopropane-1-carboxylate synthases but lacks a number of residues which are
necessary for activity
Secondary accessions: Q8WUL4 Q96LX5

Explore the universe of human proteins at neXtProt for ACCS: NX_Q96QU6

Explore proteomics data for ACCS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96QU6

  • ACCS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ACCS Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001120691.1  NP_115981.1  

    ENSEMBL proteins: 
     ENSP00000434156   ENSP00000263776   ENSP00000435919   ENSP00000391775  

    Human Recombinant Protein Products for ACCS: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for ACCS
    OriGene Protein Over-expression Lysate for ACCS
    OriGene MassSpec for ACCS 
    OriGene Custom Protein Services for ACCS
    GenScript Custom Purified and Recombinant Proteins Services for ACCS
    Novus Biologicals ACCS Proteins
    Novus Biologicals ACCS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ACCS 


    ACCS Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Custom Antibody Services for ACCS
    GenScript Custom Superior Antibodies Services for ACCS
    Novus Biologicals ACCS Antibodies
    Abcam antibodies for ACCS
    Cloud-Clone Corp. Antibodies for ACCS 
    Search ThermoFisher Antibodies for ACCS
    LSBio Antibodies in human, mouse, rat for ACCS 

    Assay Products for ACCS: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ACCS
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ACCS
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ACCS 
    Cloud-Clone Corp. CLIAs for ACCS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR004839 Aminotransferase_I/II
     IPR015424 PyrdxlP-dep_Trfase
     IPR015421 PyrdxlP-dep_Trfase_major_sub1
     IPR015422 PyrdxlP-dep_Trfase_major_sub2

    Graphical View of Domain Structure for InterPro Entry Q96QU6

    ProtoNet protein and cluster: Q96QU6

    2 Blocks protein domains:
    IPB001597 Aromatic amino acid beta-eliminating lyase/threonine aldolase
    IPB004839 Aminotransferase


    UniProtKB/Swiss-Prot: 1A1L1_HUMAN, Q96QU6
    Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family


    ACCS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 1A1L1_HUMAN, Q96QU6
    Function: Does not catalyze the synthesis of 1-aminocyclopropane-1-carboxylate but is capable of catalyzing the
    deamination of L-vinylglycine

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016847NOT 1-aminocyclopropane-1-carboxylate synthase activity IDA11470512
    GO:0030170pyridoxal phosphate binding NAS11470512
    GO:0042803protein homodimerization activity NAS11470512
         
    ACCS for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ACCS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ACCS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACCS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACCS 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACCS
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ACCS
    SwitchGear 3'UTR luciferase reporter plasmidACCS 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ACCS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACCS

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ACCS
    Sirion Biotech Customized adenovirus for overexpression of ACCS

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ACCS (see all 14)
    OriGene ORF clones in mouse, rat for ACCS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ACCS (NM_032592)
    Sino Biological Human cDNA Clone for ACCS
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACCS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACCS
    Sirion Biotech Customized lentivirus for stable overexpression of ACCS 
                         Customized lentivirus expression plasmids for stable overexpression of ACCS 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ACCS
    Search LifeMap BioReagents cell lines for ACCS
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACCS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACCS

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    4 Interacting proteins for ACCS (Q96QU62, 3 ENSP000002637764) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FBF1Q8TES72, 3, ENSP000003242924MINT-67098 I2D: score=1 STRING: ENSP00000324292
    ACCSQ96QU62MINT-66338
    --Q8IZ483I2D: score=1 
    --A6NLR53I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009058biosynthetic process ----

    ACCS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ACCS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACCS (1A1L1)

    1 DrugBank Compound for ACCS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vinylglycine(2s)-2-Amino-3-Butenoic Acid (see all 3)52773-87-2target--16667107

    9 Novoseek inferred chemical compound relationships for ACCS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    l-vinylglycine 96.8 2 11470512 (1)
    1-aminocyclopropane-1-carboxylate 95.9 29 11470512 (2), 8292015 (2), 16028113 (2), 10610793 (1) (see all 23)
    histidinol-phosphate 88 1 8292015 (1)
    ethylene 77.9 14 15949763 (3), 16315594 (2), 10610793 (1), 9539813 (1) (see all 7)
    pyridoxal 5-phosphate 74.3 4 11470512 (2), 11939774 (1)
    s-adenosylmethionine 63.7 1 11470512 (1)
    auxin 57.2 1 1421146 (1)
    aspartate 39 3 11888303 (1), 11939774 (1), 8292015 (1)
    alanine 24.2 1 8292015 (1)

    Search CenterWatch for drugs/clinical trials and news about ACCS / 1A1L1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ACCS gene (2 alternative transcripts): 
    NM_001127219.1  NM_032592.3  

    Unigene Cluster for ACCS:

    1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)
    Hs.126706  [show with all ESTs]
    Unigene Representative Sequence: NM_032592
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533208 ENST00000524990 ENST00000263776(uc010rfn.2 uc009yks.1 uc001mxx.2)
    ENST00000527603 ENST00000526577 ENST00000533404 ENST00000531940 ENST00000527346(uc010rfm.1)
    ENST00000532122 ENST00000531190 ENST00000527557 ENST00000531505 ENST00000534035
    ENST00000432284
    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ACCS
    SwitchGear 3'UTR luciferase reporter plasmidACCS 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ACCS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACCS
    Clone
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    OriGene clones in human, mouse for ACCS (see all 14)
    OriGene ORF clones in mouse, rat for ACCS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ACCS (NM_032592)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACCS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACCS
    Sirion Biotech Customized lentivirus for stable overexpression of ACCS 
                         Customized lentivirus expression plasmids for stable overexpression of ACCS 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ACCS
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACCS
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACCS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACCS

    Additional mRNA sequence: 

    AK057649.1 AK302515.1 AK304074.1 AK307380.1 AY026508.1 BC020197.1 

    10 DOTS entries:

    DT.75167276  DT.40282000  DT.428017  DT.120703143  DT.100735491  DT.100818101  DT.120703122  DT.120703136 
    DT.91663182  DT.95214606 

    24/78 AceView cDNA sequences (see all 78):

    BC020197 AW968101 CR618044 BX279727 CN484280 CR601174 AI521974 BU617320 
    AW451890 BX489169 AA286897 AI676022 BQ717703 AV648689 BX463812 AL535112 
    AL702573 AL704090 AV649108 BX479065 AV649030 BX327771 AA256057 BM763249 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ACCS (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c
    SP1:                          -                             -                                         -                       -                                 
    SP2:                          -                       -     -                                                                                                   
    SP3:                                                                          -                                               -                                 
    SP4:                          -                                                                                                                                 
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for ACCS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACCS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCGGCTCAA
    ACCS Expression
    About this image


    See ACCS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACCS

    SOURCE GeneReport for Unigene cluster: Hs.126706
        SABiosciences Custom PCR Arrays for ACCS
    Primer
    Products:
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACCS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACCS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACCS gene from 8/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Accs1 , 5 1-aminocyclopropane-1-carboxylate synthase homolog more5
    1-aminocyclopropane-1-carboxylate synthase (non-functional)1
    84.24(n)1
    84.31(a)1
      2 (51.62 cM)5
    3294701  NM_183220.21  NP_899043.11 
     938334675 
    chicken
    (Gallus gallus)
    Aves ACCS1 1-aminocyclopropane-1-carboxylate synthase homolog more 66.6(n)
    64.92(a)
      423170  XM_421096.3  XP_421096.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    57(a)
    44(a)
    many → 1
    possible ortholog
    1(45535229-45561979)
    6(21231512-21253271)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.42772 Transcribed sequence with weak similarity to protein more 79.05(n)    AL883033.2 
    zebrafish
    (Danio rerio)
    Actinopterygii accs1 1-aminocyclopropane-1-carboxylate synthase homolog more 60.67(n)
    60.05(a)
      541510  NM_001014323.1  NP_001014345.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T04F3.16
    Protein T04F3.1, isoform a
    4(a)
    1 → many
    V(11740230-11754199)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ACS91 1-aminocyclopropane-1-carboxylate synthase 9 45.9(n)
    34.87(a)
      824132  NM_114830.1  NP_190539.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g07276001 hypothetical protein 47.73(n)
    34.45(a)
      4333976  NM_001057677.1  NP_001051142.1 


    ENSEMBL Gene Tree for ACCS (if available)
    TreeFam Gene Tree for ACCS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACCS gene
    ACCSL2  
    1 SIMAP similar gene for ACCS using alignment to 4 protein entries:     1A1L1_HUMAN (see all proteins):
    ACCSL

    ACCS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/568 SNPs in ACCS are shown (see all 568)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0386864
    A breast cancer sample4--see VAR_0386862 S L mis40--------
    rs355146141,2,4
    C,FA breast cancer sample4 --44099402(-) CTAGCC/TCAGTG 4 E G mis16Minor allele frequency- T:0.01NA EA EU 6065
    rs1491922091,2
    --44085746(+) GCACAC/TAACAG 1 -- us2k10--------
    rs110378501,2
    C,F,H--44085886(+) ctagtG/Acaagg 2 -- us2k15Minor allele frequency- A:0.03NS EA 540
    rs169378101,2
    C,F,H--44085958(+) TATTGA/GGAGAT 2 -- us2k111Minor allele frequency- G:0.04NA NS EA WA 1348
    rs761434201,2
    F--44085975(+) TATTTC/ACTTTC 2 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1433908961,2
    --44086062(+) CCATTA/GCCAGA 2 -- us2k10--------
    rs2001408271,2
    --44086111(+) GAAAT-/TATATGT 2 -- us2k10--------
    rs2011300141,2
    --44086112(+) AATTA-/TGTATGT 2 -- us2k10--------
    rs714498691,2
    C--44086115(+) TTATA-/TGTG/TGT
    GTGTGTGTGTG
    TGTGT
    2 -- us2k11NA 2

    HapMap Linkage Disequilibrium report for ACCS (44087475 - 44105772 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ACCS:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv995967CNV Insertion20482838
    nsv832139CNV Loss17160897
    nsv523327CNV Gain19592680


    Human Gene Mutation Database (HGMD): ACCS
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ACCS
    DNA2.0 Custom Variant and Variant Library Synthesis for ACCS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608405    OMIM disorders: --

    12 diseases for ACCS:    About MalaCards
    lung adenoid cystic carcinoma    cutaneous adenocystic carcinoma    pancreatic acinar cell adenocarcinoma    adenoid cystic carcinoma
    tracheal cancer    adrenocortical carcinoma    esophageal adenocarcinoma    adenoiditis
    hypoxia    adenocarcinoma    pancreatitis    esophagitis

    1 disease from the University of Copenhagen DISEASES database for ACCS:
    Adenoid cystic carcinoma

    ACCS for disorders           About GeneDecksing

    Genetic Association Database (GAD): ACCS
    Human Genome Epidemiology (HuGE) Navigator: ACCS (1 document)

    Export disorders for ACCS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACCS gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with ACCS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human cDNA for a homologue of the plant enzyme 1- aminocyclopropane-1-carboxylate synthase encodes a protein lacking that activity. (PubMed id 11470512)1, 2, 3, 9 Koch K.A.... Kirsch J.F. (2001)
    2. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Inactivation of 1-Aminocyclopropane-1-Carboxylate Syn thase by l-Vinylglycine as Related to the Mechanism-Based Inactivation of the E nzyme by S-Adenosyl-l-Methionine. (PubMed id 16667107)7 Satoh S. and Yang S.F. (1989)
    10. Differential expression of genes encoding 1-aminocyclopropane-1-carboxylate synthase in Arabidopsis during hypoxia. (PubMed id 16028113)9 Peng H.P....Shih M.C. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84680 HGNC: 23989 AceView: PHACS Ensembl:ENSG00000110455 euGenes: HUgn84680
    ECgene: ACCS H-InvDB: ACCS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACCS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ACCS gene:
    Search GeneIP for patents involving ACCS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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