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Aliases for ACBD7 Gene

Aliases for ACBD7 Gene

  • Acyl-CoA Binding Domain Containing 7 2 3 5
  • Acyl-Coenzyme A Binding Domain Containing 7 2 3
  • Acyl-CoA-Binding Domain-Containing Protein 7 3
  • BA455B2.2 3

External Ids for ACBD7 Gene

Previous GeneCards Identifiers for ACBD7 Gene

  • GC10U900450
  • GC10M015157
  • GC10M015117
  • GC10M015031

Summaries for ACBD7 Gene

GeneCards Summary for ACBD7 Gene

ACBD7 (Acyl-CoA Binding Domain Containing 7) is a Protein Coding gene. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include lipid binding and fatty-acyl-CoA binding. An important paralog of this gene is DBI.

UniProtKB/Swiss-Prot for ACBD7 Gene

  • Binds medium- and long-chain acyl-CoA esters.

Additional gene information for ACBD7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACBD7 Gene

Genomics for ACBD7 Gene

Regulatory Elements for ACBD7 Gene

Enhancers for ACBD7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H015122 1.1 FANTOM5 ENCODE 19.1 -35.0 -35012 1 HDGF PKNOX1 MAX EBF1 BATF RELA GATA3 POLR2A ZNF143 FOS ACBD7 C10orf111 RPP38 GAPDHP45 DCLRE1CP1 OLAH GC10P015124 GC10P015108
GH10H014530 1.4 Ensembl ENCODE dbSUPER 9.2 +556.3 556287 3 ELF3 TBP FOXA2 MLX ARID4B RAD21 DNMT3B THRB RARA TCF12 CDNF HSPA14 SUV39H2 DCLRE1CP1 ACBD7 GAPDHP45 FAM107B GC10M014524 LOC105376429
GH10H015096 1.1 ENCODE 9.9 -9.2 -9222 3 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 SP3 MXD4 RPP38 HSPA14 C10orf111 ACBD7 LOC105376431
GH10H014498 1 Ensembl ENCODE 9.7 +589.7 589677 1 CTCF ZNF654 TRIM22 ARID4B REST ZBTB8A RAD21 ZNF217 GTF3C2 ZBTB48 HSPA14 DCLRE1C PRPF18 RPP38 CDNF ACBD7 DCLRE1CP1 GAPDHP45 GC10M014524 FRMD4A
GH10H015088 1 ENCODE 9.7 -0.1 -97 1 ATF1 ARID4B SIN3A DMAP1 ZNF2 GLIS2 ZNF143 FOS ATF7 SP3 C10orf111 MINDY3 ACBD7 RPP38 GAPDHP45
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ACBD7 on UCSC Golden Path with GeneCards custom track

Promoters for ACBD7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000024892 75 1000 ATF1 ARID4B SIN3A DMAP1 ZNF2 GLIS2 ZNF143 FOS SP3 MXD4

Genomic Location for ACBD7 Gene

Chromosome:
10
Start:
15,075,475 bp from pter
End:
15,088,776 bp from pter
Size:
13,302 bases
Orientation:
Minus strand

Genomic View for ACBD7 Gene

Genes around ACBD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACBD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACBD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACBD7 Gene

Proteins for ACBD7 Gene

  • Protein details for ACBD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6N7-ACBD7_HUMAN
    Recommended name:
    Acyl-CoA-binding domain-containing protein 7
    Protein Accession:
    Q8N6N7
    Secondary Accessions:
    • A6NCI2
    • B3KTG8

    Protein attributes for ACBD7 Gene

    Size:
    88 amino acids
    Molecular mass:
    9790 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ACBD7 Gene

neXtProt entry for ACBD7 Gene

Post-translational modifications for ACBD7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACBD7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACBD7 Gene

Domains & Families for ACBD7 Gene

Gene Families for ACBD7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ACBD7 Gene

Suggested Antigen Peptide Sequences for ACBD7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N6N7

UniProtKB/Swiss-Prot:

ACBD7_HUMAN :
  • Belongs to the ACBD7 family.
Family:
  • Belongs to the ACBD7 family.
genes like me logo Genes that share domains with ACBD7: view

Function for ACBD7 Gene

Molecular function for ACBD7 Gene

UniProtKB/Swiss-Prot Function:
Binds medium- and long-chain acyl-CoA esters.

Phenotypes From GWAS Catalog for ACBD7 Gene

Gene Ontology (GO) - Molecular Function for ACBD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000062 fatty-acyl-CoA binding IEA --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with ACBD7: view

Phenotypes for ACBD7 Gene

GenomeRNAi human phenotypes for ACBD7:
genes like me logo Genes that share phenotypes with ACBD7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ACBD7
  • Applied Biological Materials Clones for ACBD7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACBD7 Gene

Localization for ACBD7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACBD7 gene
Compartment Confidence
cytosol 3
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ACBD7 Gene

Pathways & Interactions for ACBD7 Gene

genes like me logo Genes that share pathways with ACBD7: view

Interacting Proteins for ACBD7 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000367453%0d%0a9606.ENSP00000343479%0d%0a9606.ENSP00000258960%0d%0a9606.ENSP00000367407%0d%0a9606.ENSP00000362932%0d%0a9606.ENSP00000358466%0d%0a
Selected Interacting proteins: Q8N6N7-ACBD7_HUMAN ENSP00000367453 for ACBD7 Gene via IID STRING

Gene Ontology (GO) - Biological Process for ACBD7 Gene

None

No data available for SIGNOR curated interactions for ACBD7 Gene

Drugs & Compounds for ACBD7 Gene

(2) Drugs for ACBD7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hexanoyl-CoA Experimental Pharma 0
Propanoyl-CoA Experimental Pharma 0

(30) Additional Compounds for ACBD7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACBD7: view

Transcripts for ACBD7 Gene

mRNA/cDNA for ACBD7 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACBD7 Gene

Acyl-CoA binding domain containing 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ACBD7
  • Applied Biological Materials Clones for ACBD7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ACBD7 Gene

No ASD Table

Relevant External Links for ACBD7 Gene

GeneLoc Exon Structure for
ACBD7
ECgene alternative splicing isoforms for
ACBD7

Expression for ACBD7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACBD7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACBD7 Gene

This gene is overexpressed in Brain - Amygdala (x7.4), Brain - Caudate (basal ganglia) (x6.7), Brain - Nucleus accumbens (basal ganglia) (x6.5), Brain - Putamen (basal ganglia) (x5.1), Brain - Frontal Cortex (BA9) (x4.6), Brain - Hippocampus (x4.1), and Brain - Anterior cingulate cortex (BA24) (x4.1).

Protein differential expression in normal tissues from HIPED for ACBD7 Gene

This gene is overexpressed in Fetal Brain (24.5), Brain (16.2), and Skin (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACBD7 Gene



Protein tissue co-expression partners for ACBD7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ACBD7 Gene:

ACBD7

SOURCE GeneReport for Unigene cluster for ACBD7 Gene:

Hs.644598

Evidence on tissue expression from TISSUES for ACBD7 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ACBD7: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACBD7 Gene

Orthologs for ACBD7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACBD7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACBD7 33 34
  • 98.86 (n)
dog
(Canis familiaris)
Mammalia ACBD7 33
  • 91.29 (n)
-- 34
  • 43 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia ACBD7 34
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acbd7 33 16 34
  • 82.95 (n)
rat
(Rattus norvegicus)
Mammalia Acbd7 33
  • 82.95 (n)
cow
(Bos Taurus)
Mammalia ACBD7 33 34
  • 82.58 (n)
chicken
(Gallus gallus)
Aves ACBD7 33 34
  • 82.58 (n)
lizard
(Anolis carolinensis)
Reptilia ACBD7 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acbd7 33
  • 76.14 (n)
zebrafish
(Danio rerio)
Actinopterygii acbd7 33 34
  • 66.67 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000546 33
  • 61.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8498 33
  • 56.82 (n)
CG8628 34
  • 48 (a)
ManyToMany
CG8629 34
  • 48 (a)
ManyToMany
CG5804 34
  • 41 (a)
ManyToMany
CG15829 34
  • 39 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea acbp-1 34
  • 52 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ACB1 34
  • 44 (a)
OneToMany
Species where no ortholog for ACBD7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACBD7 Gene

ENSEMBL:
Gene Tree for ACBD7 (if available)
TreeFam:
Gene Tree for ACBD7 (if available)

Paralogs for ACBD7 Gene

Paralogs for ACBD7 Gene

(7) SIMAP similar genes for ACBD7 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ACBD7 Gene

genes like me logo Genes that share paralogs with ACBD7: view

Variants for ACBD7 Gene

Sequence variations from dbSNP and Humsavar for ACBD7 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000098112 -- 15,075,989(+) AAAAA(A/G)AAAAA intron-variant, utr-variant-3-prime
rs1000310335 -- 15,080,938(+) TGCTG(G/T)CCACC intron-variant
rs1000514913 -- 15,086,819(+) GACCA(A/C)CCTGA intron-variant
rs1000530287 -- 15,079,426(+) TGCAC(C/G)ACCAC intron-variant
rs1000598676 -- 15,080,578(+) CTGTC(C/T)CAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACBD7 Gene

Variant ID Type Subtype PubMed ID
nsv831794 CNV loss 17160897

Variation tolerance for ACBD7 Gene

Residual Variation Intolerance Score: 69.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACBD7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACBD7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACBD7 Gene

Disorders for ACBD7 Gene

Relevant External Links for ACBD7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACBD7

No disorders were found for ACBD7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACBD7 Gene

Publications for ACBD7 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 60

Products for ACBD7 Gene

  • Addgene plasmids for ACBD7

Sources for ACBD7 Gene

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