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Aliases for ACBD6 Gene

Aliases for ACBD6 Gene

  • Acyl-CoA Binding Domain Containing 6 2 3 5
  • Acyl-Coenzyme A Binding Domain Containing 6 2

External Ids for ACBD6 Gene

Previous GeneCards Identifiers for ACBD6 Gene

  • GC01M177496
  • GC01M176989
  • GC01M178523
  • GC01M180244
  • GC01M151488
  • GC01M180270

Summaries for ACBD6 Gene

GeneCards Summary for ACBD6 Gene

ACBD6 (Acyl-CoA Binding Domain Containing 6) is a Protein Coding gene. Diseases associated with ACBD6 include Sialolithiasis and Parotid Disease. GO annotations related to this gene include lipid binding and fatty-acyl-CoA binding.

UniProtKB/Swiss-Prot for ACBD6 Gene

  • Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACBD6 Gene

Genomics for ACBD6 Gene

Regulatory Elements for ACBD6 Gene

Enhancers for ACBD6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ACBD6 on UCSC Golden Path with GeneCards custom track

Promoters for ACBD6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ACBD6 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACBD6 Gene

Chromosome:
1
Start:
180,269,653 bp from pter
End:
180,502,967 bp from pter
Size:
233,315 bases
Orientation:
Minus strand

Genomic View for ACBD6 Gene

Genes around ACBD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACBD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACBD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACBD6 Gene

Proteins for ACBD6 Gene

  • Protein details for ACBD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BR61-ACBD6_HUMAN
    Recommended name:
    Acyl-CoA-binding domain-containing protein 6
    Protein Accession:
    Q9BR61

    Protein attributes for ACBD6 Gene

    Size:
    282 amino acids
    Molecular mass:
    31151 Da
    Quaternary structure:
    • Monomer.
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for ACBD6 Gene

neXtProt entry for ACBD6 Gene

Proteomics data for ACBD6 Gene at MOPED

Post-translational modifications for ACBD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACBD6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACBD6 Gene

Domains & Families for ACBD6 Gene

Gene Families for ACBD6 Gene

Suggested Antigen Peptide Sequences for ACBD6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BR61

UniProtKB/Swiss-Prot:

ACBD6_HUMAN :
  • Contains 1 ACB (acyl-CoA-binding) domain.
  • Contains 2 ANK repeats.
Domain:
  • Contains 1 ACB (acyl-CoA-binding) domain.
Similarity:
  • Contains 2 ANK repeats.
genes like me logo Genes that share domains with ACBD6: view

Function for ACBD6 Gene

Molecular function for ACBD6 Gene

UniProtKB/Swiss-Prot Function:
Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids.

Gene Ontology (GO) - Molecular Function for ACBD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000062 fatty-acyl-CoA binding IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ACBD6: view

Phenotypes for ACBD6 Gene

GenomeRNAi human phenotypes for ACBD6:
genes like me logo Genes that share phenotypes with ACBD6: view

Animal Model Products

miRNA for ACBD6 Gene

miRTarBase miRNAs that target ACBD6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACBD6 Gene

Localization for ACBD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACBD6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACBD6 Gene COMPARTMENTS Subcellular localization image for ACBD6 gene
Compartment Confidence
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for ACBD6 Gene

Pathways & Interactions for ACBD6 Gene

SuperPathways for ACBD6 Gene

No Data Available

Interacting Proteins for ACBD6 Gene

Gene Ontology (GO) - Biological Process for ACBD6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ACBD6 Gene

Drugs & Compounds for ACBD6 Gene

(1) Drugs for ACBD6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propionyl-CoA Experimental Pharma 0

(31) Additional Compounds for ACBD6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACBD6: view

Transcripts for ACBD6 Gene

Unigene Clusters for ACBD6 Gene

Acyl-CoA binding domain containing 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACBD6 Gene

No ASD Table

Relevant External Links for ACBD6 Gene

GeneLoc Exon Structure for
ACBD6
ECgene alternative splicing isoforms for
ACBD6

Expression for ACBD6 Gene

mRNA expression in normal human tissues for ACBD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ACBD6 Gene

This gene is overexpressed in Lymph node (11.2), Monocytes (9.8), and Testis (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ACBD6 Gene



SOURCE GeneReport for Unigene cluster for ACBD6 Gene Hs.200051

mRNA Expression by UniProt/SwissProt for ACBD6 Gene

Q9BR61-ACBD6_HUMAN
Tissue specificity: Detected in placenta and spleen (at protein level). Detected in placenta, umbilical cord blood, CD34-positive hematopoietic progenitor cells and bone marrow.
genes like me logo Genes that share expression patterns with ACBD6: view

Protein tissue co-expression partners for ACBD6 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for ACBD6 Gene

Orthologs for ACBD6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACBD6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACBD6 35
  • 90.31 (n)
  • 89.36 (a)
dog
(Canis familiaris)
Mammalia ACBD6 35
  • 90.43 (n)
  • 89.36 (a)
mouse
(Mus musculus)
Mammalia Acbd6 35
  • 86.52 (n)
  • 85.82 (a)
Acbd6 16
chimpanzee
(Pan troglodytes)
Mammalia ACBD6 35
  • 99.53 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Acbd6 35
  • 87.12 (n)
  • 86.88 (a)
chicken
(Gallus gallus)
Aves ACBD6 35
  • 74.03 (n)
  • 77.53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia acbd6 35
  • 65.65 (n)
  • 63.74 (a)
Str.87 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6444 35
zebrafish
(Danio rerio)
Actinopterygii acbd6 35
  • 67.37 (n)
  • 67.93 (a)
wufc18d09 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5351 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000752 35
  • 46.88 (n)
  • 38.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33713 35
  • 43.71 (n)
  • 34.65 (a)
worm
(Caenorhabditis elegans)
Secernentea acbp-5 35
  • 43.83 (n)
  • 31.94 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ACBP1 35
  • 48.1 (n)
  • 40.65 (a)
rice
(Oryza sativa)
Liliopsida Os04g0681900 35
  • 49.48 (n)
  • 41.73 (a)
Species with no ortholog for ACBD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACBD6 Gene

ENSEMBL:
Gene Tree for ACBD6 (if available)
TreeFam:
Gene Tree for ACBD6 (if available)

Paralogs for ACBD6 Gene

No data available for Paralogs for ACBD6 Gene

Variants for ACBD6 Gene

Sequence variations from dbSNP and Humsavar for ACBD6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs822703 -- 180,299,085(-) AGAAG(C/T)ATATA intron-variant
rs822704 -- 180,328,641(+) TATGA(C/T)AAGTG intron-variant
rs822705 -- 180,329,032(+) CATCA(C/T)CCCTG intron-variant
rs822706 -- 180,331,293(+) TTTGT(C/T)ATAAT intron-variant
rs961162 -- 180,496,503(-) GGCAG(G/T)CAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACBD6 Gene

Variant ID Type Subtype PubMed ID
nsv832004 CNV Gain 17160897
nsv466239 CNV Gain 19166990
esv2673419 CNV Deletion 23128226
esv2650355 CNV Deletion 19546169
nsv527918 CNV Gain 19592680
esv2576257 CNV Deletion 19546169
esv2136642 CNV Deletion 18987734
esv1001564 CNV Deletion 20482838
esv5032 CNV Deletion 18987735
esv2719918 CNV Deletion 23290073
esv1123070 CNV Deletion 17803354
esv6088 CNV Loss 19470904
nsv3766 CNV Insertion 18451855
esv2664302 CNV Deletion 23128226

Variation tolerance for ACBD6 Gene

Residual Variation Intolerance Score: 28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACBD6 Gene

Human Gene Mutation Database (HGMD)
ACBD6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACBD6 Gene

Disorders for ACBD6 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ACBD6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
sialolithiasis
  • salivary gland stone
parotid disease
  • parotid diseases
parotitis
salivary gland disease
  • non-neoplastic salivary gland disease
- elite association - COSMIC cancer census association via MalaCards
Search ACBD6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ACBD6

Genetic Association Database (GAD)
ACBD6
Human Genome Epidemiology (HuGE) Navigator
ACBD6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACBD6
genes like me logo Genes that share disorders with ACBD6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACBD6 Gene

Publications for ACBD6 Gene

  1. Characterization of an acyl-coenzyme A binding protein predominantly expressed in human primitive progenitor cells. (PMID: 18268358) Soupene E. … Kuypers F.A. (J. Lipid Res. 2008) 2 3 4 67
  2. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 3
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. Expanding the substantial interactome of NEMO using protein microarrays. (PMID: 20098747) Fenner B.J. … Prehn J.H. (PLoS ONE 2010) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for ACBD6 Gene

Sources for ACBD6 Gene

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