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Aliases for ACBD6 Gene

Aliases for ACBD6 Gene

  • Acyl-CoA Binding Domain Containing 6 2 3 5
  • Acyl-Coenzyme A Binding Domain Containing 6 2

External Ids for ACBD6 Gene

Previous GeneCards Identifiers for ACBD6 Gene

  • GC01M177496
  • GC01M176989
  • GC01M178523
  • GC01M180244
  • GC01M151488
  • GC01M180270
  • GC01M180336
  • GC01M180404
  • GC01M180430
  • GC01M180524

Summaries for ACBD6 Gene

GeneCards Summary for ACBD6 Gene

ACBD6 (Acyl-CoA Binding Domain Containing 6) is a Protein Coding gene. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include lipid binding and fatty-acyl-CoA binding. An important paralog of this gene is ANKRD31.

UniProtKB/Swiss-Prot for ACBD6 Gene

  • Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids.

Additional gene information for ACBD6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACBD6 Gene

Genomics for ACBD6 Gene

Regulatory Elements for ACBD6 Gene

Enhancers for ACBD6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H181126 2 FANTOM5 Ensembl ENCODE dbSUPER 42.1 -626.4 -626370 6 HDGF PKNOX1 ARNT FEZF1 ZNF2 FOS ZNF548 ZC3H11A JUNB REST LHX4 ACBD6 KIAA1614 IER5 MR1 GC01M181116 LINC01732
GH01H180584 1.6 FANTOM5 Ensembl ENCODE 18.5 -83.2 -83178 2 PKNOX1 FOXA2 ATF1 ARNT TCF12 FOS ATF7 SP5 GTF2B ZC3H11A ACBD6 LHX4 XPR1 CEP350 MR1 OVAAL
GH01H181151 2.5 VISTA FANTOM5 Ensembl ENCODE dbSUPER 11.2 -649.9 -649855 3 HDGF PKNOX1 ARNT ZNF766 CBX5 ZNF143 FOS ZC3H11A JUNB REST IER5 ACBD6 MR1 ENSG00000243155 LINC01732 GC01M181116
GH01H181132 2 FANTOM5 Ensembl ENCODE dbSUPER 12.5 -631.9 -631949 4 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 ZNF207 FOS LHX4 IER5 ENSG00000225359 ENSG00000232309 ACBD6 KIAA1614 MR1 STX6 GC01M181116 LINC01732
GH01H181086 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -589.6 -589596 11 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC MEF2D ZNF610 LHX4 IER5 ENSG00000225359 MR1 ACBD6 STX6 GC01M181092 GC01M181116
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ACBD6 on UCSC Golden Path with GeneCards custom track

Promoters for ACBD6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000016545 467 1801 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 ZNF610 GLIS1 NBN NR2C1

Genomic Location for ACBD6 Gene

Chromosome:
1
Start:
180,269,653 bp from pter
End:
180,502,967 bp from pter
Size:
233,315 bases
Orientation:
Minus strand

Genomic View for ACBD6 Gene

Genes around ACBD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACBD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACBD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACBD6 Gene

Proteins for ACBD6 Gene

  • Protein details for ACBD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BR61-ACBD6_HUMAN
    Recommended name:
    Acyl-CoA-binding domain-containing protein 6
    Protein Accession:
    Q9BR61

    Protein attributes for ACBD6 Gene

    Size:
    282 amino acids
    Molecular mass:
    31151 Da
    Quaternary structure:
    • Monomer.
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for ACBD6 Gene

neXtProt entry for ACBD6 Gene

Post-translational modifications for ACBD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACBD6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACBD6 Gene

Domains & Families for ACBD6 Gene

Gene Families for ACBD6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ACBD6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ACBD6: view

No data available for UniProtKB/Swiss-Prot for ACBD6 Gene

Function for ACBD6 Gene

Molecular function for ACBD6 Gene

UniProtKB/Swiss-Prot Function:
Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids.

Gene Ontology (GO) - Molecular Function for ACBD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000062 fatty-acyl-CoA binding IEA --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with ACBD6: view

Phenotypes for ACBD6 Gene

GenomeRNAi human phenotypes for ACBD6:
genes like me logo Genes that share phenotypes with ACBD6: view

Animal Model Products

CRISPR Products

miRNA for ACBD6 Gene

miRTarBase miRNAs that target ACBD6

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ACBD6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACBD6 Gene

Localization for ACBD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACBD6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACBD6 gene
Compartment Confidence
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ACBD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ACBD6: view

Pathways & Interactions for ACBD6 Gene

genes like me logo Genes that share pathways with ACBD6: view

Gene Ontology (GO) - Biological Process for ACBD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006637 acyl-CoA metabolic process TAS --
genes like me logo Genes that share ontologies with ACBD6: view

No data available for SIGNOR curated interactions for ACBD6 Gene

Drugs & Compounds for ACBD6 Gene

(2) Drugs for ACBD6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hexanoyl-CoA Experimental Pharma 0
Propanoyl-CoA Experimental Pharma 0

(30) Additional Compounds for ACBD6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACBD6: view

Transcripts for ACBD6 Gene

Unigene Clusters for ACBD6 Gene

Acyl-CoA binding domain containing 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ACBD6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ACBD6 Gene

No ASD Table

Relevant External Links for ACBD6 Gene

GeneLoc Exon Structure for
ACBD6
ECgene alternative splicing isoforms for
ACBD6

Expression for ACBD6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACBD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ACBD6 Gene

This gene is overexpressed in Lymph node (11.2), Monocytes (9.8), and Testis (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ACBD6 Gene



Protein tissue co-expression partners for ACBD6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ACBD6 Gene:

ACBD6

SOURCE GeneReport for Unigene cluster for ACBD6 Gene:

Hs.200051

mRNA Expression by UniProt/SwissProt for ACBD6 Gene:

Q9BR61-ACBD6_HUMAN
Tissue specificity: Detected in placenta and spleen (at protein level). Detected in placenta, umbilical cord blood, CD34-positive hematopoietic progenitor cells and bone marrow.

Evidence on tissue expression from TISSUES for ACBD6 Gene

  • Lung(4.3)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with ACBD6: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACBD6 Gene

Orthologs for ACBD6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACBD6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACBD6 33
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia ACBD6 33
  • 90.43 (n)
cow
(Bos Taurus)
Mammalia ACBD6 33
  • 90.31 (n)
rat
(Rattus norvegicus)
Mammalia Acbd6 33
  • 87.12 (n)
mouse
(Mus musculus)
Mammalia Acbd6 33 16
  • 86.52 (n)
chicken
(Gallus gallus)
Aves ACBD6 33
  • 74.03 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia acbd6 33
  • 65.65 (n)
Str.87 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6444 33
zebrafish
(Danio rerio)
Actinopterygii acbd6 33
  • 67.37 (n)
wufc18d09 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5351 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000752 33
  • 46.88 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG33713 33
  • 43.71 (n)
worm
(Caenorhabditis elegans)
Secernentea acbp-5 33
  • 43.83 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ACBP1 33
  • 48.1 (n)
rice
(Oryza sativa)
Liliopsida Os04g0681900 33
  • 49.48 (n)
Species where no ortholog for ACBD6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACBD6 Gene

ENSEMBL:
Gene Tree for ACBD6 (if available)
TreeFam:
Gene Tree for ACBD6 (if available)

Paralogs for ACBD6 Gene

Paralogs for ACBD6 Gene

genes like me logo Genes that share paralogs with ACBD6: view

Variants for ACBD6 Gene

Sequence variations from dbSNP and Humsavar for ACBD6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs121912641 Pathogenic 180,271,856(+) GAAGG(C/G)CCAAA nc-transcript-variant, reference, missense
rs121912643 Pathogenic 180,271,497(+) GCAGC(G/T)GTCCT nc-transcript-variant, reference, missense
rs121912644 Pathogenic 180,274,568(+) ATCAT(A/C)CTCCT intron-variant, nc-transcript-variant, reference, missense
rs786204780 Pathogenic 180,271,378(+) CTTGC(A/C/G)GATGA nc-transcript-variant, splice-acceptor-variant
rs116482990 Likely benign 180,274,596(+) CCCCA(A/C/T)CCTAC intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ACBD6 Gene

Variant ID Type Subtype PubMed ID
dgv15e215 CNV deletion 23714750
dgv228n106 CNV deletion 24896259
esv1001564 CNV deletion 20482838
esv1123070 CNV deletion 17803354
esv2136642 CNV deletion 18987734
esv2576257 CNV deletion 19546169
esv2650355 CNV deletion 19546169
esv2664302 CNV deletion 23128226
esv2673419 CNV deletion 23128226
esv2719918 CNV deletion 23290073
esv2762200 CNV gain 21179565
esv3543267 CNV deletion 23714750
esv3588066 CNV loss 21293372
esv3588067 CNV loss 21293372
esv3588068 CNV loss 21293372
esv5032 CNV loss 18987735
esv6088 CNV loss 19470904
nsv1003359 CNV gain 25217958
nsv1009742 CNV loss 25217958
nsv1014937 CNV loss 25217958
nsv1068334 CNV deletion 25765185
nsv3766 CNV insertion 18451855
nsv466239 CNV gain 19166990
nsv476151 CNV novel sequence insertion 20440878
nsv477185 CNV novel sequence insertion 20440878
nsv527918 CNV gain 19592680
nsv548345 CNV gain 21841781
nsv832004 CNV gain 17160897
nsv946528 CNV duplication 23825009
nsv952296 CNV duplication 24416366
nsv957237 CNV deletion 24416366

Variation tolerance for ACBD6 Gene

Residual Variation Intolerance Score: 28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACBD6 Gene

Human Gene Mutation Database (HGMD)
ACBD6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACBD6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACBD6 Gene

Disorders for ACBD6 Gene

Relevant External Links for ACBD6

Genetic Association Database (GAD)
ACBD6
Human Genome Epidemiology (HuGE) Navigator
ACBD6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACBD6

No disorders were found for ACBD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACBD6 Gene

Publications for ACBD6 Gene

  1. Characterization of an acyl-coenzyme A binding protein predominantly expressed in human primitive progenitor cells. (PMID: 18268358) Soupene E … Kuypers FA (Journal of lipid research 2008) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Association of NMT2 with the acyl-CoA carrier ACBD6 protects the N-myristoyltransferase reaction from palmitoyl-CoA. (PMID: 26621918) Soupene E … Kuypers FA (Journal of lipid research 2016) 3 60

Products for ACBD6 Gene

Sources for ACBD6 Gene

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