Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ACBD6 Gene

Aliases for ACBD6 Gene

  • Acyl-CoA Binding Domain Containing 6 2 3 5
  • Acyl-Coenzyme A Binding Domain Containing 6 2

External Ids for ACBD6 Gene

Previous GeneCards Identifiers for ACBD6 Gene

  • GC01M177496
  • GC01M176989
  • GC01M178523
  • GC01M180244
  • GC01M151488
  • GC01M180270
  • GC01M180336
  • GC01M180404

Summaries for ACBD6 Gene

GeneCards Summary for ACBD6 Gene

ACBD6 (Acyl-CoA Binding Domain Containing 6) is a Protein Coding gene. Among its related pathways are Metabolism and Fatty Acyl-CoA Biosynthesis. GO annotations related to this gene include lipid binding and fatty-acyl-CoA binding.

UniProtKB/Swiss-Prot for ACBD6 Gene

  • Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACBD6 Gene

Genomics for ACBD6 Gene

Regulatory Elements for ACBD6 Gene

Enhancers for ACBD6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F181126 1.9 FANTOM5 Ensembl ENCODE 22 -629.0 -628953 11.4 FEZF1 DMAP1 YBX1 ZNF548 ZNF263 SP3 TBX21 ZFP41 MEF2D ZNF610 LHX4 ACBD6 IER5 ENSG00000225359 ENSG00000232309 MR1 KIAA1614 STX6 GC01M181116 LINC01732
GH01F181158 1.6 FANTOM5 Ensembl ENCODE 22 -657.4 -657434 3.6 HDGF PKNOX1 ARNT ZNF493 ZNF121 GATA2 FOS ZNF548 KDM4B MCM5 LHX4 IER5 ACBD6 MR1 KIAA1614 STX6 LINC01732 GC01M181116
GH01F180584 1.6 FANTOM5 Ensembl ENCODE 18.5 -83.2 -83178 2.7 ATF1 ARNT ZNF48 GATA2 FOS SP5 GTF2B CREB3 MBD2 SMARCA4 ACBD6 XPR1 LHX4 MR1 OVAAL
GH01F181148 2.2 VISTA FANTOM5 Ensembl ENCODE 11.3 -648.5 -648494 6.1 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 SIN3A FEZF1 CBX5 ZNF207 FOS IER5 MR1 ACBD6 KIAA1614 LOC105371638 ENSG00000243155 LINC01732 GC01M181116
GH01F180562 1.2 Ensembl ENCODE 19.6 -60.2 -60225 1.6 HDGF HDAC1 ATF1 PKNOX1 NFRKB PTRF GATA2 KLF13 ZBTB2 TFDP1 ACBD6 XPR1 LHX4 OVAAL
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ACBD6 on UCSC Golden Path with GeneCards custom track

Promoters for ACBD6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ACBD6 Gene

180,269,653 bp from pter
180,502,967 bp from pter
233,315 bases
Minus strand

Genomic View for ACBD6 Gene

Genes around ACBD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACBD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACBD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACBD6 Gene

Proteins for ACBD6 Gene

  • Protein details for ACBD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acyl-CoA-binding domain-containing protein 6
    Protein Accession:

    Protein attributes for ACBD6 Gene

    282 amino acids
    Molecular mass:
    31151 Da
    Quaternary structure:
    • Monomer.
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for ACBD6 Gene

neXtProt entry for ACBD6 Gene

Post-translational modifications for ACBD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACBD6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACBD6 Gene

Domains & Families for ACBD6 Gene

Gene Families for ACBD6 Gene

Suggested Antigen Peptide Sequences for ACBD6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 ACB (acyl-CoA-binding) domain.
  • Contains 2 ANK repeats.
  • Contains 1 ACB (acyl-CoA-binding) domain.
  • Contains 2 ANK repeats.
genes like me logo Genes that share domains with ACBD6: view

Function for ACBD6 Gene

Molecular function for ACBD6 Gene

UniProtKB/Swiss-Prot Function:
Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids.

Gene Ontology (GO) - Molecular Function for ACBD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000062 fatty-acyl-CoA binding IEA --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with ACBD6: view

Phenotypes for ACBD6 Gene

GenomeRNAi human phenotypes for ACBD6:
genes like me logo Genes that share phenotypes with ACBD6: view

Animal Model Products

miRNA for ACBD6 Gene

miRTarBase miRNAs that target ACBD6

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACBD6 Gene

Localization for ACBD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACBD6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACBD6 gene
Compartment Confidence
cytosol 5

Gene Ontology (GO) - Cellular Components for ACBD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ACBD6: view

Drugs & Compounds for ACBD6 Gene

(1) Drugs for ACBD6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propionyl-CoA Experimental Pharma 0

(31) Additional Compounds for ACBD6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
genes like me logo Genes that share compounds with ACBD6: view

Transcripts for ACBD6 Gene

Unigene Clusters for ACBD6 Gene

Acyl-CoA binding domain containing 6:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACBD6 Gene

No ASD Table

Relevant External Links for ACBD6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACBD6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ACBD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ACBD6 Gene

This gene is overexpressed in Lymph node (11.2), Monocytes (9.8), and Testis (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACBD6 Gene

Protein tissue co-expression partners for ACBD6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ACBD6 Gene:


SOURCE GeneReport for Unigene cluster for ACBD6 Gene:


mRNA Expression by UniProt/SwissProt for ACBD6 Gene:

Tissue specificity: Detected in placenta and spleen (at protein level). Detected in placenta, umbilical cord blood, CD34-positive hematopoietic progenitor cells and bone marrow.
genes like me logo Genes that share expression patterns with ACBD6: view

No data available for mRNA differential expression in normal tissues for ACBD6 Gene

Orthologs for ACBD6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACBD6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACBD6 34
  • 99.53 (n)
(Canis familiaris)
Mammalia ACBD6 34
  • 90.43 (n)
(Bos Taurus)
Mammalia ACBD6 34
  • 90.31 (n)
(Rattus norvegicus)
Mammalia Acbd6 34
  • 87.12 (n)
(Mus musculus)
Mammalia Acbd6 34 16
  • 86.52 (n)
(Gallus gallus)
Aves ACBD6 34
  • 74.03 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia acbd6 34
  • 65.65 (n)
Str.87 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6444 34
(Danio rerio)
Actinopterygii acbd6 34
  • 67.37 (n)
wufc18d09 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5351 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000752 34
  • 46.88 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG33713 34
  • 43.71 (n)
(Caenorhabditis elegans)
Secernentea acbp-5 34
  • 43.83 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ACBP1 34
  • 48.1 (n)
(Oryza sativa)
Liliopsida Os04g0681900 34
  • 49.48 (n)
Species where no ortholog for ACBD6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACBD6 Gene

Gene Tree for ACBD6 (if available)
Gene Tree for ACBD6 (if available)

Paralogs for ACBD6 Gene

No data available for Paralogs for ACBD6 Gene

Variants for ACBD6 Gene

Sequence variations from dbSNP and Humsavar for ACBD6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs121912641 Pathogenic 180,271,856(+) GAAGG(C/G)CCAAA nc-transcript-variant, reference, missense
rs121912643 Pathogenic 180,271,497(+) GCAGC(G/T)GTCCT nc-transcript-variant, reference, missense
rs121912644 Pathogenic 180,274,568(+) ATCAT(A/C)CTCCT intron-variant, nc-transcript-variant, reference, missense
rs786204780 Pathogenic 180,271,378(+) CTTGC(A/C)GATGA nc-transcript-variant, splice-acceptor-variant
rs3806302 Benign 180,272,020(-) CCCCT(A/C)CAGCC intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ACBD6 Gene

Variant ID Type Subtype PubMed ID
nsv957237 CNV deletion 24416366
nsv952296 CNV duplication 24416366
nsv946528 CNV duplication 23825009
nsv832004 CNV gain 17160897
nsv548345 CNV gain 21841781
nsv527918 CNV gain 19592680
nsv477185 CNV novel sequence insertion 20440878
nsv476151 CNV novel sequence insertion 20440878
nsv466239 CNV gain 19166990
nsv3766 CNV insertion 18451855
nsv1068334 CNV deletion 25765185
nsv1014937 CNV loss 25217958
nsv1009742 CNV loss 25217958
nsv1003359 CNV gain 25217958
esv6088 CNV loss 19470904
esv5032 CNV loss 18987735
esv3588068 CNV loss 21293372
esv3588067 CNV loss 21293372
esv3588066 CNV loss 21293372
esv3543267 CNV deletion 23714750
esv2762200 CNV gain 21179565
esv2719918 CNV deletion 23290073
esv2673419 CNV deletion 23128226
esv2664302 CNV deletion 23128226
esv2650355 CNV deletion 19546169
esv2576257 CNV deletion 19546169
esv2136642 CNV deletion 18987734
esv1123070 CNV deletion 17803354
esv1001564 CNV deletion 20482838
dgv228n106 CNV deletion 24896259
dgv15e215 CNV deletion 23714750

Variation tolerance for ACBD6 Gene

Residual Variation Intolerance Score: 28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACBD6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACBD6 Gene

Disorders for ACBD6 Gene

Relevant External Links for ACBD6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ACBD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACBD6 Gene

Publications for ACBD6 Gene

  1. Characterization of an acyl-coenzyme A binding protein predominantly expressed in human primitive progenitor cells. (PMID: 18268358) Soupene E. … Kuypers F.A. (J. Lipid Res. 2008) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Association of NMT2 with the acyl-CoA carrier ACBD6 protects the N-myristoyltransferase reaction from palmitoyl-CoA. (PMID: 26621918) Soupene E. … Kuypers F.A. (J. Lipid Res. 2016) 3 64

Products for ACBD6 Gene

Sources for ACBD6 Gene

Loading form....