Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ACBD5 Gene

Aliases for ACBD5 Gene

  • Acyl-CoA Binding Domain Containing 5 2 3
  • Acyl-Coenzyme A Binding Domain Containing 5 2
  • KIAA1996 4

External Ids for ACBD5 Gene

Previous GeneCards Identifiers for ACBD5 Gene

  • GC10M027489
  • GC10M027488
  • GC10M027525
  • GC10M027484
  • GC10M027152

Summaries for ACBD5 Gene

Entrez Gene Summary for ACBD5 Gene

  • This gene encodes a member of the acyl-Coenzyme A binding protein family, known to function in the transport and distribution of long chain acyl-Coenzyme A in cells. This gene may play a role in the differentiation of megakaryocytes and formation of platelets. A related protein in yeast is involved in autophagy of peroxisomes. A mutation in this gene has been associated with autosomal dominant thrombocytopenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for ACBD5 Gene

ACBD5 (Acyl-CoA Binding Domain Containing 5) is a Protein Coding gene. Diseases associated with ACBD5 include thrombocytopenia. GO annotations related to this gene include lipid binding and fatty-acyl-CoA binding. An important paralog of this gene is ACBD4.

UniProtKB/Swiss-Prot for ACBD5 Gene

  • Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACBD5 Gene

Genomics for ACBD5 Gene

Regulatory Elements for ACBD5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ACBD5 Gene

Start:
27,195,214 bp from pter
End:
27,242,275 bp from pter
Size:
47,062 bases
Orientation:
Minus strand

Genomic View for ACBD5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACBD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACBD5 Gene

Proteins for ACBD5 Gene

  • Protein details for ACBD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T8D3-ACBD5_HUMAN
    Recommended name:
    Acyl-CoA-binding domain-containing protein 5
    Protein Accession:
    Q5T8D3
    Secondary Accessions:
    • B3KQ56
    • D3DRW0
    • Q5T8D4
    • Q5T8E1
    • Q5T8E2
    • Q86UV1
    • Q8N6E3
    • Q9UFB5

    Protein attributes for ACBD5 Gene

    Size:
    534 amino acids
    Molecular mass:
    60092 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH30555.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ACBD5 Gene

    Alternative splice isoforms for ACBD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACBD5 Gene

Proteomics data for ACBD5 Gene at MOPED

Post-translational modifications for ACBD5 Gene

  • Ubiquitination at Lys469
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ACBD5 Gene

Domains for ACBD5 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T8D3

UniProtKB/Swiss-Prot:

ACBD5_HUMAN :
  • Q5T8D3
Domain:
  • Contains 1 ACB (acyl-CoA-binding) domain.
Family:
  • Belongs to the ATG37 family.
genes like me logo Genes that share domains with ACBD5: view

No data available for Gene Families for ACBD5 Gene

Function for ACBD5 Gene

Molecular function for ACBD5 Gene

UniProtKB/Swiss-Prot Function: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.

Gene Ontology (GO) - Molecular Function for ACBD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000062 fatty-acyl-CoA binding IEA --
GO:0003674 molecular_function ND --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with ACBD5: view

Phenotypes for ACBD5 Gene

GenomeRNAi human phenotypes for ACBD5:
genes like me logo Genes that share phenotypes with ACBD5: view

Animal Model Products

CRISPR Products

miRNA for ACBD5 Gene

miRTarBase miRNAs that target ACBD5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACBD5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ACBD5 Gene

Localization for ACBD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACBD5 Gene

Peroxisome membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACBD5 Gene COMPARTMENTS Subcellular localization image for ACBD5 gene
Compartment Confidence
peroxisome 5
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ACBD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005777 peroxisome IDA 24535825
GO:0005778 peroxisomal membrane IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ACBD5: view

Pathways for ACBD5 Gene

SuperPathways for ACBD5 Gene

No Data Available

Interacting Proteins for ACBD5 Gene

Gene Ontology (GO) - Biological Process for ACBD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0016236 NOT macroautophagy IMP 24535825
GO:0030242 peroxisome degradation IMP 24535825
GO:0035973 NOT aggrephagy IMP 24535825
genes like me logo Genes that share ontologies with ACBD5: view

No data available for Pathways by source for ACBD5 Gene

Compounds for ACBD5 Gene

(32) HMDB Compounds for ACBD5 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACBD5: view

Transcripts for ACBD5 Gene

Unigene Clusters for ACBD5 Gene

Acyl-CoA binding domain containing 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACBD5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACBD5 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6: - - -
SP7: -

Relevant External Links for ACBD5 Gene

GeneLoc Exon Structure for
ACBD5
ECgene alternative splicing isoforms for
ACBD5

Expression for ACBD5 Gene

mRNA expression in normal human tissues for ACBD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACBD5 Gene

SOURCE GeneReport for Unigene cluster for ACBD5 Gene Hs.530597

genes like me logo Genes that share expressions with ACBD5: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ACBD5 Gene

Orthologs for ACBD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACBD5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACBD5 35
  • 99.43 (n)
  • 100 (a)
ACBD5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACBD5 35
  • 86.37 (n)
  • 84.84 (a)
ACBD5 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACBD5 35
  • 89.75 (n)
  • 90.91 (a)
ACBD5 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acbd5 35
  • 84.91 (n)
  • 83.4 (a)
Acbd5 16
Acbd5 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACBD5 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACBD5 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acbd5 35
  • 84.22 (n)
  • 82.94 (a)
chicken
(Gallus gallus)
Aves ACBD5 35
  • 72.38 (n)
  • 65.29 (a)
ACBD5 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACBD5 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acbd5 35
  • 63.78 (n)
  • 59.45 (a)
Str.7418 35
zebrafish
(Danio rerio)
Actinopterygii acbd5a 35
  • 55.32 (n)
  • 46.6 (a)
acbd5a 36
  • 43 (a)
OneToMany
acbd5b 36
  • 33 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8814 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea acbp-3 36
  • 32 (a)
ManyToMany
acbp-4 36
  • 32 (a)
ManyToMany
maa-1 36
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for ACBD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACBD5 Gene

ENSEMBL:
Gene Tree for ACBD5 (if available)
TreeFam:
Gene Tree for ACBD5 (if available)

Paralogs for ACBD5 Gene

Paralogs for ACBD5 Gene

Selected SIMAP similar genes for ACBD5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ACBD5: view

Variants for ACBD5 Gene

Sequence variations from dbSNP and Humsavar for ACBD5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs34703806 -- 27,241,175(+) AGCGC(A/C/T)TGCAC intron-variant, upstream-variant-2KB
rs144230661 -- 27,219,316(+) AAAAC(-/A/AA)AAAAA intron-variant
rs184208853 -- 27,207,626(+) GAAGC(A/G/T)GCAGC intron-variant
rs189496200 -- 27,214,843(+) GAGTT(C/G/T)GAGAC intron-variant
rs192464203 -- 27,237,194(+) TATGT(A/C/T)TATTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACBD5 Gene

Variant ID Type Subtype PubMed ID
esv2664616 CNV Deletion 23128226
esv2422253 CNV Deletion 17116639
nsv894980 CNV Gain 21882294
nsv8614 CNV Loss 18304495

Relevant External Links for ACBD5 Gene

HapMap Linkage Disequilibrium report
ACBD5
Human Gene Mutation Database (HGMD)
ACBD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACBD5 Gene

Disorders for ACBD5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ACBD5 Gene including...

Search for ACBD5 Gene in MalaCards »

Relevant External Links for ACBD5

Genetic Association Database (GAD)
ACBD5
Human Genome Epidemiology (HuGE) Navigator
ACBD5
genes like me logo Genes that share disorders with ACBD5: view

No data available for UniProtKB/Swiss-Prot for ACBD5 Gene

Publications for ACBD5 Gene

  1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  2. Peroxisomal Atg37 binds Atg30 or palmitoyl-CoA to regulate phagophore formation during pexophagy. (PMID: 24535825) Nazarko T.Y. … Subramani S. (J. Cell Biol. 2014) 3 4
  3. Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. (PMID: 12056414) Ohara O. … Koseki H. (DNA Res. 2002) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3

Products for ACBD5 Gene

  • Addgene plasmids for ACBD5

Sources for ACBD5 Gene

Back to Top

Content