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Aliases for ACBD5 Gene

Aliases for ACBD5 Gene

  • Acyl-CoA Binding Domain Containing 5 2 3 5
  • Acyl-Coenzyme A Binding Domain Containing 5 2
  • KIAA1996 4

External Ids for ACBD5 Gene

Previous GeneCards Identifiers for ACBD5 Gene

  • GC10M027489
  • GC10M027488
  • GC10M027525
  • GC10M027484
  • GC10M027152

Summaries for ACBD5 Gene

Entrez Gene Summary for ACBD5 Gene

  • This gene encodes a member of the acyl-Coenzyme A binding protein family, known to function in the transport and distribution of long chain acyl-Coenzyme A in cells. This gene may play a role in the differentiation of megakaryocytes and formation of platelets. A related protein in yeast is involved in autophagy of peroxisomes. A mutation in this gene has been associated with autosomal dominant thrombocytopenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for ACBD5 Gene

ACBD5 (Acyl-CoA Binding Domain Containing 5) is a Protein Coding gene. GO annotations related to this gene include lipid binding and fatty-acyl-CoA binding. An important paralog of this gene is ACBD4.

UniProtKB/Swiss-Prot for ACBD5 Gene

  • Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACBD5 Gene

Genomics for ACBD5 Gene

Regulatory Elements for ACBD5 Gene

Enhancers for ACBD5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ACBD5 on UCSC Golden Path with GeneCards custom track

Promoters for ACBD5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ACBD5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACBD5 Gene

Chromosome:
10
Start:
27,195,214 bp from pter
End:
27,242,139 bp from pter
Size:
46,926 bases
Orientation:
Minus strand

Genomic View for ACBD5 Gene

Genes around ACBD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACBD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACBD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACBD5 Gene

Proteins for ACBD5 Gene

  • Protein details for ACBD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T8D3-ACBD5_HUMAN
    Recommended name:
    Acyl-CoA-binding domain-containing protein 5
    Protein Accession:
    Q5T8D3
    Secondary Accessions:
    • B3KQ56
    • D3DRW0
    • Q5T8D4
    • Q5T8E1
    • Q5T8E2
    • Q86UV1
    • Q8N6E3
    • Q9UFB5

    Protein attributes for ACBD5 Gene

    Size:
    534 amino acids
    Molecular mass:
    60092 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH30555.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ACBD5 Gene

    Alternative splice isoforms for ACBD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACBD5 Gene

Proteomics data for ACBD5 Gene at MOPED

Post-translational modifications for ACBD5 Gene

  • Ubiquitination at Lys 469
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ACBD5 Gene

Domains & Families for ACBD5 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T8D3

UniProtKB/Swiss-Prot:

ACBD5_HUMAN :
  • Contains 1 ACB (acyl-CoA-binding) domain.
  • Belongs to the ATG37 family.
Domain:
  • Contains 1 ACB (acyl-CoA-binding) domain.
Family:
  • Belongs to the ATG37 family.
genes like me logo Genes that share domains with ACBD5: view

No data available for Gene Families for ACBD5 Gene

Function for ACBD5 Gene

Molecular function for ACBD5 Gene

UniProtKB/Swiss-Prot Function:
Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.

Gene Ontology (GO) - Molecular Function for ACBD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000062 fatty-acyl-CoA binding IEA --
genes like me logo Genes that share ontologies with ACBD5: view
genes like me logo Genes that share phenotypes with ACBD5: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACBD5 Gene

Localization for ACBD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACBD5 Gene

Peroxisome membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACBD5 Gene COMPARTMENTS Subcellular localization image for ACBD5 gene
Compartment Confidence
nucleus 5
peroxisome 5
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ACBD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome IDA 24535825
GO:0005778 peroxisomal membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ACBD5: view

Pathways & Interactions for ACBD5 Gene

SuperPathways for ACBD5 Gene

No Data Available

Interacting Proteins for ACBD5 Gene

Gene Ontology (GO) - Biological Process for ACBD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0016236 NOT macroautophagy IMP 24535825
genes like me logo Genes that share ontologies with ACBD5: view

No data available for Pathways by source and SIGNOR curated interactions for ACBD5 Gene

Drugs & Compounds for ACBD5 Gene

(1) Drugs for ACBD5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propionyl-CoA Experimental Pharma 0

(31) Additional Compounds for ACBD5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACBD5: view

Transcripts for ACBD5 Gene

Unigene Clusters for ACBD5 Gene

Acyl-CoA binding domain containing 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACBD5 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6: - - -
SP7: -

Relevant External Links for ACBD5 Gene

GeneLoc Exon Structure for
ACBD5
ECgene alternative splicing isoforms for
ACBD5

Expression for ACBD5 Gene

mRNA expression in normal human tissues for ACBD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ACBD5 Gene

This gene is overexpressed in Lung (24.2), Bone (15.6), and Testis (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ACBD5 Gene



SOURCE GeneReport for Unigene cluster for ACBD5 Gene Hs.530597

genes like me logo Genes that share expression patterns with ACBD5: view

Protein tissue co-expression partners for ACBD5 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ACBD5 Gene

Orthologs for ACBD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACBD5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACBD5 35
  • 86.37 (n)
  • 84.84 (a)
ACBD5 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACBD5 35
  • 89.75 (n)
  • 90.91 (a)
ACBD5 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acbd5 35
  • 84.91 (n)
  • 83.4 (a)
Acbd5 16
Acbd5 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ACBD5 35
  • 99.43 (n)
  • 100 (a)
ACBD5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acbd5 35
  • 84.22 (n)
  • 82.94 (a)
oppossum
(Monodelphis domestica)
Mammalia ACBD5 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACBD5 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACBD5 35
  • 72.38 (n)
  • 65.29 (a)
ACBD5 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACBD5 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acbd5 35
  • 63.78 (n)
  • 59.45 (a)
Str.7418 35
zebrafish
(Danio rerio)
Actinopterygii acbd5a 35
  • 55.32 (n)
  • 46.6 (a)
acbd5a 36
  • 43 (a)
OneToMany
acbd5b 36
  • 33 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8814 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea acbp-3 36
  • 32 (a)
ManyToMany
acbp-4 36
  • 32 (a)
ManyToMany
maa-1 36
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for ACBD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACBD5 Gene

ENSEMBL:
Gene Tree for ACBD5 (if available)
TreeFam:
Gene Tree for ACBD5 (if available)

Paralogs for ACBD5 Gene

Paralogs for ACBD5 Gene

(6) SIMAP similar genes for ACBD5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ACBD5: view

Variants for ACBD5 Gene

Sequence variations from dbSNP and Humsavar for ACBD5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs7918793 - 27,208,262(+) TCAGC(A/G)TTTCC reference, missense
rs1557163 -- 27,220,716(+) aaatg(C/T)gaggg intron-variant
rs1557164 -- 27,220,900(+) AGGCA(A/C)GACTG intron-variant
rs1557165 -- 27,220,948(+) ACAAA(C/T)ATCAA intron-variant
rs1557166 -- 27,221,064(+) AGTAA(A/C)TAACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACBD5 Gene

Variant ID Type Subtype PubMed ID
esv2664616 CNV Deletion 23128226
esv2422253 CNV Deletion 17116639
nsv894980 CNV Gain 21882294
nsv8614 CNV Loss 18304495

Variation tolerance for ACBD5 Gene

Residual Variation Intolerance Score: 48.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.63; 72.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACBD5 Gene

HapMap Linkage Disequilibrium report
ACBD5
Human Gene Mutation Database (HGMD)
ACBD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACBD5 Gene

Disorders for ACBD5 Gene

Relevant External Links for ACBD5

Genetic Association Database (GAD)
ACBD5
Human Genome Epidemiology (HuGE) Navigator
ACBD5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACBD5

No disorders were found for ACBD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACBD5 Gene

Publications for ACBD5 Gene

  1. Peroxisomal Atg37 binds Atg30 or palmitoyl-CoA to regulate phagophore formation during pexophagy. (PMID: 24535825) Nazarko T.Y. … Subramani S. (J. Cell Biol. 2014) 3 4 67
  2. Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. (PMID: 12056414) Ohara O. … Koseki H. (DNA Res. 2002) 2 3
  3. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3
  4. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for ACBD5 Gene

Sources for ACBD5 Gene

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