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Aliases for ACBD4 Gene

Aliases for ACBD4 Gene

  • Acyl-CoA Binding Domain Containing 4 2 3 5
  • Acyl-Coenzyme A Binding Domain Containing 4 2 3
  • Acyl-CoA-Binding Domain-Containing Protein 4 3
  • HMFT0700 3

External Ids for ACBD4 Gene

Previous GeneCards Identifiers for ACBD4 Gene

  • GC17P043685
  • GC17P043688
  • GC17P040565
  • GC17P043209
  • GC17P038976

Summaries for ACBD4 Gene

Entrez Gene Summary for ACBD4 Gene

  • This gene encodes a member of the acyl-coenzyme A binding domain containing protein family. All family members contain the conserved acyl-Coenzyme A binding domain, which binds acyl-CoA thiol esters. They are thought to play roles in acyl-CoA dependent lipid metabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for ACBD4 Gene

ACBD4 (Acyl-CoA Binding Domain Containing 4) is a Protein Coding gene. Among its related pathways are Metabolism and Peroxisomal lipid metabolism. GO annotations related to this gene include lipid binding and fatty-acyl-CoA binding. An important paralog of this gene is ACBD5.

UniProtKB/Swiss-Prot for ACBD4 Gene

  • Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACBD4 Gene

Genomics for ACBD4 Gene

Regulatory Elements for ACBD4 Gene

Enhancers for ACBD4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G045121 1.9 FANTOM5 Ensembl ENCODE dbSUPER 20.5 -8.6 -8648 4.0 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 FOS ZNF263 SP5 ACBD4 ENSG00000224505 HEXIM2 DCAKD PLCD3 SLC25A39 MIR6784
GH17G045126 1.4 ENCODE dbSUPER 21.2 -2.6 -2552 6.9 HDGF PKNOX1 FOXA2 MLX ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ENSG00000262372 ASB16-AS1 ACBD4 LINC02210 ENSG00000224505 DCAKD GPATCH8 PLCD3 RUNDC3A-AS1 ENSG00000266918
GH17G045089 2 FANTOM5 Ensembl ENCODE dbSUPER 13.5 -40.4 -40395 4.6 CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 MEF2D SSRP1 DCAKD PLCD3 GFAP NMT1 ACBD4 HEXIM1 GPATCH8 ENSG00000262372 EFTUD2 HIGD1B
GH17G045134 1.1 ENCODE 21.6 +3.3 3282 1.9 HDGF PKNOX1 MLX CREB3L1 ARNT WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ACBD4 PLCD3 HEXIM1
GH17G045196 1.4 Ensembl ENCODE 12.7 +65.1 65145 1.9 HDGF MLX ARNT AGO1 WRNIP1 ARID4B SIN3A ZNF2 ZNF207 ZNF143 HEXIM1 PLCD3 ACBD4 DCAKD ENSG00000233483 ENSG00000267405 GC17P045196 FMNL1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ACBD4 on UCSC Golden Path with GeneCards custom track

Promoters for ACBD4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000094874 100 1801 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF143 ZNF207 ZNF263

Genomic Location for ACBD4 Gene

Chromosome:
17
Start:
45,132,600 bp from pter
End:
45,144,181 bp from pter
Size:
11,582 bases
Orientation:
Plus strand

Genomic View for ACBD4 Gene

Genes around ACBD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACBD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACBD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACBD4 Gene

Proteins for ACBD4 Gene

  • Protein details for ACBD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NC06-ACBD4_HUMAN
    Recommended name:
    Acyl-CoA-binding domain-containing protein 4
    Protein Accession:
    Q8NC06
    Secondary Accessions:
    • D3DX64
    • Q8IUT1
    • Q9H8Q4

    Protein attributes for ACBD4 Gene

    Size:
    268 amino acids
    Molecular mass:
    30308 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ACBD4 Gene

    Alternative splice isoforms for ACBD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACBD4 Gene

Post-translational modifications for ACBD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ACBD4 Gene

Domains & Families for ACBD4 Gene

Suggested Antigen Peptide Sequences for ACBD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ACBD4: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ACBD4 Gene

Function for ACBD4 Gene

Molecular function for ACBD4 Gene

UniProtKB/Swiss-Prot Function:
Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters.

Gene Ontology (GO) - Molecular Function for ACBD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000062 fatty-acyl-CoA binding IEA --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with ACBD4: view
genes like me logo Genes that share phenotypes with ACBD4: view

Animal Model Products

CRISPR Products

miRNA for ACBD4 Gene

miRTarBase miRNAs that target ACBD4

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ACBD4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACBD4 Gene

Localization for ACBD4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACBD4 gene
Compartment Confidence
cytosol 3
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ACBD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ACBD4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ACBD4 Gene

Pathways & Interactions for ACBD4 Gene

genes like me logo Genes that share pathways with ACBD4: view

Pathways by source for ACBD4 Gene

Gene Ontology (GO) - Biological Process for ACBD4 Gene

None

No data available for SIGNOR curated interactions for ACBD4 Gene

Drugs & Compounds for ACBD4 Gene

(1) Drugs for ACBD4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propionyl-CoA Experimental Pharma 0

(31) Additional Compounds for ACBD4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACBD4: view

Transcripts for ACBD4 Gene

Unigene Clusters for ACBD4 Gene

Acyl-CoA binding domain containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ACBD4

Alternative Splicing Database (ASD) splice patterns (SP) for ACBD4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - - - - -
SP6: - -
SP7: -
SP8:
SP9: - -
SP10: -

ExUns: 14a · 14b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for ACBD4 Gene

GeneLoc Exon Structure for
ACBD4
ECgene alternative splicing isoforms for
ACBD4

Expression for ACBD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACBD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACBD4 Gene

This gene is overexpressed in Liver (x4.8).

Protein differential expression in normal tissues from HIPED for ACBD4 Gene

This gene is overexpressed in Monocytes (67.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ACBD4 Gene



Protein tissue co-expression partners for ACBD4 Gene

NURSA nuclear receptor signaling pathways regulating expression of ACBD4 Gene:

ACBD4

SOURCE GeneReport for Unigene cluster for ACBD4 Gene:

Hs.110298

Evidence on tissue expression from TISSUES for ACBD4 Gene

  • Nervous system(4.5)
  • Liver(4.3)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with ACBD4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACBD4 Gene

Orthologs for ACBD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACBD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACBD4 34 35
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia ACBD4 34 35
  • 87.82 (n)
cow
(Bos Taurus)
Mammalia ACBD4 34 35
  • 84.82 (n)
mouse
(Mus musculus)
Mammalia Acbd4 34 16 35
  • 83.67 (n)
rat
(Rattus norvegicus)
Mammalia Acbd4 34
  • 83.56 (n)
oppossum
(Monodelphis domestica)
Mammalia ACBD4 35
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACBD4 35
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC780283 34
  • 57.64 (n)
zebrafish
(Danio rerio)
Actinopterygii acbd4 34 35
  • 53.23 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8814 35
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea acbp-3 35
  • 34 (a)
ManyToMany
acbp-4 35
  • 31 (a)
ManyToMany
maa-1 35
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 21 (a)
OneToMany
Species where no ortholog for ACBD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACBD4 Gene

ENSEMBL:
Gene Tree for ACBD4 (if available)
TreeFam:
Gene Tree for ACBD4 (if available)

Paralogs for ACBD4 Gene

Paralogs for ACBD4 Gene

(4) SIMAP similar genes for ACBD4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ACBD4: view

Variants for ACBD4 Gene

Sequence variations from dbSNP and Humsavar for ACBD4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000037052 -- 45,132,545(+) CGGAG(C/G)AGGCA upstream-variant-2KB
rs1000165344 -- 45,136,307(+) GGTCC(C/T)GATCA intron-variant
rs1000499129 -- 45,130,704(+) TTCGC(C/T)CCTGC intron-variant, upstream-variant-2KB
rs1000762805 -- 45,142,971(+) GACCT(C/T)GCTTT intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1001063151 -- 45,132,259(+) TCTTC(A/G)GCGCC upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ACBD4 Gene

Variant ID Type Subtype PubMed ID
esv1790779 OTHER inversion 17803354
esv2061968 CNV deletion 18987734
esv2516666 CNV deletion 19546169
esv2666936 CNV deletion 23128226
nsv1146669 OTHER inversion 26484159
nsv527788 CNV loss 19592680
nsv828022 CNV gain 20364138
nsv953903 CNV deletion 24416366

Variation tolerance for ACBD4 Gene

Residual Variation Intolerance Score: 88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.58; 44.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACBD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACBD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACBD4 Gene

Disorders for ACBD4 Gene

Relevant External Links for ACBD4

Genetic Association Database (GAD)
ACBD4
Human Genome Epidemiology (HuGE) Navigator
ACBD4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACBD4

No disorders were found for ACBD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACBD4 Gene

Publications for ACBD4 Gene

  1. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3 46 64
  2. Genome-wide association study identifies eight loci associated with blood pressure. (PMID: 19430483) Newton-Cheh C. … Munroe P.B. (Nat. Genet. 2009) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S. … Nakagawara A. (Oncogene 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ACBD4 Gene

  • Addgene plasmids for ACBD4

Sources for ACBD4 Gene

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