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Aliases for ACBD4 Gene

Aliases for ACBD4 Gene

  • Acyl-CoA Binding Domain Containing 4 2 3 5
  • Acyl-Coenzyme A Binding Domain Containing 4 2 3
  • HMFT0700 3

External Ids for ACBD4 Gene

Previous GeneCards Identifiers for ACBD4 Gene

  • GC17P043685
  • GC17P043688
  • GC17P040565
  • GC17P043209
  • GC17P038976

Summaries for ACBD4 Gene

Entrez Gene Summary for ACBD4 Gene

  • This gene encodes a member of the acyl-coenzyme A binding domain containing protein family. All family members contain the conserved acyl-Coenzyme A binding domain, which binds acyl-CoA thiol esters. They are thought to play roles in acyl-CoA dependent lipid metabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for ACBD4 Gene

ACBD4 (Acyl-CoA Binding Domain Containing 4) is a Protein Coding gene. GO annotations related to this gene include lipid binding and fatty-acyl-CoA binding. An important paralog of this gene is ACBD5.

UniProtKB/Swiss-Prot for ACBD4 Gene

  • Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACBD4 Gene

Genomics for ACBD4 Gene

Regulatory Elements for ACBD4 Gene

Enhancers for ACBD4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ACBD4 on UCSC Golden Path with GeneCards custom track

Promoters for ACBD4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ACBD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACBD4 Gene

45,132,600 bp from pter
45,144,181 bp from pter
11,582 bases
Plus strand

Genomic View for ACBD4 Gene

Genes around ACBD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACBD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACBD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACBD4 Gene

Proteins for ACBD4 Gene

  • Protein details for ACBD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acyl-CoA-binding domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • D3DX64
    • Q8IUT1
    • Q9H8Q4

    Protein attributes for ACBD4 Gene

    268 amino acids
    Molecular mass:
    30308 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ACBD4 Gene

    Alternative splice isoforms for ACBD4 Gene


neXtProt entry for ACBD4 Gene

Proteomics data for ACBD4 Gene at MOPED

Post-translational modifications for ACBD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ACBD4 Gene

Domains & Families for ACBD4 Gene

Suggested Antigen Peptide Sequences for ACBD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 ACB (acyl-CoA-binding) domain.
  • Contains 1 ACB (acyl-CoA-binding) domain.
genes like me logo Genes that share domains with ACBD4: view

No data available for Gene Families for ACBD4 Gene

Function for ACBD4 Gene

Molecular function for ACBD4 Gene

UniProtKB/Swiss-Prot Function:
Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters.

Gene Ontology (GO) - Molecular Function for ACBD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000062 fatty-acyl-CoA binding IEA --
genes like me logo Genes that share ontologies with ACBD4: view
genes like me logo Genes that share phenotypes with ACBD4: view

Animal Model Products

miRNA for ACBD4 Gene

miRTarBase miRNAs that target ACBD4

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACBD4 Gene

Localization for ACBD4 Gene

Subcellular locations from

Jensen Localization Image for ACBD4 Gene COMPARTMENTS Subcellular localization image for ACBD4 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ACBD4 Gene

Pathways & Interactions for ACBD4 Gene

SuperPathways for ACBD4 Gene

No Data Available

Interacting Proteins for ACBD4 Gene

Gene Ontology (GO) - Biological Process for ACBD4 Gene


No data available for Pathways by source and SIGNOR curated interactions for ACBD4 Gene

Drugs & Compounds for ACBD4 Gene

(1) Drugs for ACBD4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propionyl-CoA Experimental Pharma 0

(31) Additional Compounds for ACBD4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
genes like me logo Genes that share compounds with ACBD4: view

Transcripts for ACBD4 Gene

Unigene Clusters for ACBD4 Gene

Acyl-CoA binding domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACBD4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - - - - -
SP6: - -
SP7: -
SP9: - -
SP10: -

ExUns: 14a · 14b

Relevant External Links for ACBD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACBD4 Gene

mRNA expression in normal human tissues for ACBD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACBD4 Gene

This gene is overexpressed in Liver (x4.8).

Protein differential expression in normal tissues from HIPED for ACBD4 Gene

This gene is overexpressed in Monocytes (67.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ACBD4 Gene

SOURCE GeneReport for Unigene cluster for ACBD4 Gene Hs.110298

genes like me logo Genes that share expression patterns with ACBD4: view

Protein tissue co-expression partners for ACBD4 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ACBD4 Gene

Orthologs for ACBD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACBD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ACBD4 35
  • 84.82 (n)
  • 82.18 (a)
ACBD4 36
  • 54 (a)
(Canis familiaris)
Mammalia ACBD4 35
  • 87.82 (n)
  • 85.05 (a)
ACBD4 36
  • 55 (a)
(Mus musculus)
Mammalia Acbd4 35
  • 83.67 (n)
  • 80 (a)
Acbd4 16
Acbd4 36
  • 49 (a)
(Pan troglodytes)
Mammalia ACBD4 35
  • 99.56 (n)
  • 98.69 (a)
ACBD4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Acbd4 35
  • 83.56 (n)
  • 80.87 (a)
(Monodelphis domestica)
Mammalia ACBD4 36
  • 43 (a)
(Anolis carolinensis)
Reptilia ACBD4 36
  • 38 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC780283 35
  • 57.64 (n)
  • 50.84 (a)
(Danio rerio)
Actinopterygii acbd4 35
  • 53.23 (n)
  • 50.19 (a)
acbd4 36
  • 27 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8814 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea acbp-3 36
  • 34 (a)
acbp-4 36
  • 31 (a)
maa-1 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
Species with no ortholog for ACBD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACBD4 Gene

Gene Tree for ACBD4 (if available)
Gene Tree for ACBD4 (if available)

Paralogs for ACBD4 Gene

Paralogs for ACBD4 Gene

(4) SIMAP similar genes for ACBD4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ACBD4: view

Variants for ACBD4 Gene

Sequence variations from dbSNP and Humsavar for ACBD4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs901754 - 45,137,077(-) ACAGG(A/G)GCTCG reference, missense
rs16939879 - 45,139,105(+) CATGC(A/G)GGAGG intron-variant, reference, missense
rs1053578 -- 45,143,918(+) GCTTC(C/T)CCCCG utr-variant-3-prime
rs1542688 -- 45,138,265(-) GGTGG(A/G)AGAAC intron-variant
rs2291446 -- 45,135,911(-) CGAGG(C/G)AGGTG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ACBD4 Gene

Variant ID Type Subtype PubMed ID
nsv527788 CNV Loss 19592680
dgv3178n71 CNV Loss 21882294
nsv908297 CNV Loss 21882294
dgv3179n71 CNV Loss 21882294
nsv908300 CNV Loss 21882294
esv1790779 OTHER Inversion 17803354
esv2666936 CNV Deletion 23128226
nsv828022 CNV Gain 20364138
esv2516666 CNV Deletion 19546169
esv2061968 CNV Deletion 18987734

Variation tolerance for ACBD4 Gene

Residual Variation Intolerance Score: 88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.58; 44.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ACBD4 Gene

Disorders for ACBD4 Gene

Relevant External Links for ACBD4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ACBD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACBD4 Gene

Publications for ACBD4 Gene

  1. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3 48 67
  2. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  3. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for ACBD4 Gene

Sources for ACBD4 Gene