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Aliases for ACBD3 Gene

Aliases for ACBD3 Gene

  • Acyl-CoA Binding Domain Containing 3 2 3
  • PBR- And PKA-Associated Protein 7 2 3 4
  • GOCAP1 3 4 6
  • GOLPH1 3 4 6
  • GCP60 3 4 6
  • Peripheral Benzodiazepine Receptor-Associated Protein PAP7 3 4
  • Acyl-Coenzyme A Binding Domain Containing 3 2 3
  • Golgi Complex Associated Protein 1, 60kDa 2 3
  • Golgi Phosphoprotein 1 3 4
  • Acyl-CoA-Binding Domain-Containing Protein 3 4
  • Golgi Complex-Associated Protein 1 4
  • PKA (RIalpha)-Associated Protein 3
  • Golgi Resident Protein GCP60 3
  • PAP7 3

External Ids for ACBD3 Gene

Previous Symbols for ACBD3 Gene

  • GOLPH1
  • GOCAP1

Summaries for ACBD3 Gene

Entrez Gene Summary for ACBD3 Gene

  • The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is involved in the maintenance of Golgi structure and function through its interaction with the integral membrane protein giantin. It may also be involved in the hormonal regulation of steroid formation. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACBD3 Gene

ACBD3 (Acyl-CoA Binding Domain Containing 3) is a Protein Coding gene. Among its related pathways are Benzodiazepine Pathway, Pharmacodynamics. GO annotations related to this gene include fatty-acyl-CoA binding. An important paralog of this gene is TMED8.

UniProtKB/Swiss-Prot for ACBD3 Gene

  • Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity).

Gene Wiki entry for ACBD3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACBD3 Gene

Genomics for ACBD3 Gene

Genomic Location for ACBD3 Gene

Start:
226,144,679 bp from pter
End:
226,186,730 bp from pter
Size:
42,052 bases
Orientation:
Minus strand

Genomic View for ACBD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACBD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACBD3 Gene

Regulatory Elements for ACBD3 Gene

Proteins for ACBD3 Gene

  • Protein details for ACBD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3P7-GCP60_HUMAN
    Recommended name:
    Golgi resident protein GCP60
    Protein Accession:
    Q9H3P7
    Secondary Accessions:
    • B2RB29
    • Q5VTJ0
    • Q6P9F1
    • Q8IZC5
    • Q8N4D6
    • Q9H6U3

    Protein attributes for ACBD3 Gene

    Size:
    528 amino acids
    Molecular mass:
    60593 Da
    Quaternary structure:
    • Interacts with the C-terminal cytoplasmic domain of giantin/GOLGB1. Interacts with PBR and PKA regulatory subunit RI-alpha. Does not interact with PKA regulatory subunit RI-beta nor PKA regulatory subunit RII-alpha (By similarity).

neXtProt entry for ACBD3 Gene

Proteomics data for ACBD3 Gene at MOPED

Post-translational modifications for ACBD3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys507

Other Protein References for ACBD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACBD3 Gene

Domains for ACBD3 Gene

Gene Families for ACBD3 Gene

HGNC:
  • AKAP :A-kinase anchor proteins

UniProtKB/Swiss-Prot:

GCP60_HUMAN
Domain:
  • The GOLD domain is essential for giantin binding:
    • Q9H3P7
  • Contains 1 ACB (acyl-CoA-binding) domain.:
    • Q9H3P7
  • Contains 1 GOLD domain.:
    • Q9H3P7
genes like me logo Genes that share domains with ACBD3: view

Function for ACBD3 Gene

Molecular function for ACBD3 Gene

UniProtKB/Swiss-Prot Function: Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity).

Gene Ontology (GO) - Molecular Function for ACBD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000062 fatty-acyl-CoA binding IEA --
GO:0005515 protein binding IPI 22124328
genes like me logo Genes that share ontologies with ACBD3: view

Phenotypes for ACBD3 Gene

GenomeRNAi human phenotypes for ACBD3:
genes like me logo Genes that share phenotypes with ACBD3: view

miRNA for ACBD3 Gene

miRTarBase miRNAs that target ACBD3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ACBD3 Gene

Localization for ACBD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACBD3 Gene

Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion. Note=Also mitochondrial (via its interaction with PBR). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACBD3 Gene COMPARTMENTS Subcellular localization image for ACBD3 gene
Compartment Confidence
golgi apparatus 5
cytosol 2
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for ACBD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005739 mitochondrion IEA --
GO:0005794 Golgi apparatus IDA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ACBD3: view

Pathways for ACBD3 Gene

genes like me logo Genes that share pathways with ACBD3: view

Pathways by source for ACBD3 Gene

1 PharmGKB pathway for ACBD3 Gene

Gene Ontology (GO) - Biological Process for ACBD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006694 steroid biosynthetic process IEA --
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with ACBD3: view

Compounds for ACBD3 Gene

(32) HMDB Compounds for ACBD3 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(3) Novoseek inferred chemical compound relationships for ACBD3 Gene

Compound -log(P) Hits PubMed IDs
benzodiazepine 76.8 6
steroid 52.5 9
cholesterol 32.5 5
genes like me logo Genes that share compounds with ACBD3: view

Transcripts for ACBD3 Gene

mRNA/cDNA for ACBD3 Gene

Unigene Clusters for ACBD3 Gene

Acyl-CoA binding domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACBD3 Gene

No ASD Table

Relevant External Links for ACBD3 Gene

GeneLoc Exon Structure for
ACBD3
ECgene alternative splicing isoforms for
ACBD3

Expression for ACBD3 Gene

mRNA expression in normal human tissues for ACBD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACBD3 Gene

SOURCE GeneReport for Unigene cluster for ACBD3 Gene Hs.520207

mRNA Expression by UniProt/SwissProt for ACBD3 Gene

Q9H3P7-GCP60_HUMAN
Tissue specificity: Ubiquitous, with highest expression in testis and ovary.
genes like me logo Genes that share expressions with ACBD3: view

Orthologs for ACBD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACBD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACBD3 36
  • 99.56 (n)
  • 99.81 (a)
ACBD3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACBD3 36
  • 94.26 (n)
  • 96.97 (a)
ACBD3 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACBD3 36
  • 90.69 (n)
  • 96.08 (a)
ACBD3 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acbd3 36
  • 86.67 (n)
  • 88.19 (a)
Acbd3 16
Acbd3 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACBD3 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACBD3 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acbd3 36
  • 86.22 (n)
  • 87.62 (a)
chicken
(Gallus gallus)
Aves ACBD3 36
  • 79.52 (n)
  • 84.11 (a)
ACBD3 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACBD3 37
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acbd3 36
  • 72.83 (n)
  • 81.89 (a)
Str.11138 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
ACBD3 37
  • 56 (a)
OneToOne
zgc:162964 36
  • 61.5 (n)
  • 62.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14232 37
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y41E3.7 37
  • 42 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4248 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.413 37
  • 43 (a)
OneToOne
Species with no ortholog for ACBD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACBD3 Gene

ENSEMBL:
Gene Tree for ACBD3 (if available)
TreeFam:
Gene Tree for ACBD3 (if available)

Paralogs for ACBD3 Gene

Paralogs for ACBD3 Gene

genes like me logo Genes that share paralogs with ACBD3: view

Variants for ACBD3 Gene

Sequence variations from dbSNP and Humsavar for ACBD3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1043641 -- 226,145,292(-) TAACT(A/G)CAGTA utr-variant-3-prime
rs1062716 -- 226,146,583(-) AGTCT(A/T)GGGTT utr-variant-3-prime
rs1219663 -- 226,162,666(+) TCAGA(C/T)AAGAC intron-variant
rs1219664 -- 226,165,648(+) CATAA(G/T)CAGAT intron-variant
rs1219665 -- 226,166,178(+) ttaga(C/G)agagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACBD3 Gene

Variant ID Type Subtype PubMed ID
nsv832747 CNV Gain 17160897
nsv873232 CNV Gain 21882294
nsv832759 CNV Loss 17160897
nsv819122 CNV Loss 19587683
nsv826897 CNV Loss 20364138
esv2591433 CNV Insertion 19546169

Relevant External Links for ACBD3 Gene

HapMap Linkage Disequilibrium report
ACBD3

Disorders for ACBD3 Gene

(1) Novoseek inferred disease relationships for ACBD3 Gene

Disease -log(P) Hits PubMed IDs
hypercortisolism 67 2

Relevant External Links for ACBD3

Genetic Association Database (GAD)
ACBD3
Human Genome Epidemiology (HuGE) Navigator
ACBD3
genes like me logo Genes that share disorders with ACBD3: view

No data available for UniProtKB/Swiss-Prot for ACBD3 Gene

Publications for ACBD3 Gene

  1. Molecular cloning, chromosomal localization of human peripheral-type benzodiazepine receptor and PKA regulatory subunit type 1A (PRKAR1A)-associated protein PAP7, and studies in PRKAR1A mutant cells and tissues. (PMID: 12692076) Liu J. … Papadopoulos V. (FASEB J. 2003) 2 3 23
  2. Molecular cloning, genomic organization, chromosomal mapping and subcellular localization of mouse PAP7: a PBR and PKA-RIalpha associated protein. (PMID: 12711385) Liu J. … Papadopoulos V. (Gene 2003) 3 23
  3. Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin. (PMID: 11590181) Sohda M. … Ikehara Y. (J. Biol. Chem. 2001) 3 4
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for ACBD3 Gene

Sources for ACBD3 Gene

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