Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACBD3 Gene

protein-coding   GIFtS: 54
GCID: GC01M226332

acyl-CoA binding domain containing 3

(Previous names: golgi complex associated protein 1, 60kDa, acyl-Coenzyme...)
(Previous symbols: GOLPH1, GOCAP1)
 Explore 3 diseases affiliated with
ACBD3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ACBD3    

Aliases
for ACBD3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Acyl-CoA Binding Domain Containing 31 2     Golgi Phosphoprotein 12 3
GCP601 2 3 5     Peripheral Benzodiazepine Receptor-Associated Protein PAP72 3
GOCAP11 2 3 5     PBR- And PKA-Associated Protein 72 3
GOLPH11 2 3 5     Golgi Resident Protein GCP602
PAP71 2     PKA (RIalpha)-Associated Protein2
Acyl-Coenzyme A Binding Domain Containing 31 2     Acyl-CoA-Binding Domain-Containing Protein 33
Golgi Complex Associated Protein 1, 60kDa1 2     Golgi Complex-Associated Protein 13

External Ids:    HGNC: 154531   Entrez Gene: 647462   Ensembl: ENSG000001828277   OMIM: 6068095   UniProtKB: Q9H3P73   

Export aliases for ACBD3 gene to outside databases

Previous GC identifers: GC01M223307 GC01M222639 GC01M224399 GC01M196849


Summaries
for ACBD3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ACBD3:
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum.
The protein encoded by this gene is involved in the maintenance of Golgi structure and function through its
interaction with the integral membrane protein giantin. It may also be involved in the hormonal regulation of steroid
formation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GCP60_HUMAN, Q9H3P7
Function: Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport
between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig
cells (By similarity)

Gene Wiki entry for ACBD3


Genomic Views
for ACBD3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACBD3 gene promoter:
         Nkx3-1   Nkx3-1 v4   Pax-5   Nkx3-1 v1   MIF-1   Egr-4   GATA-1   Evi-1   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ACBD3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ACBD3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACBD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.12   Ensembl cytogenetic band:  1q42.12   HGNC cytogenetic band: 1q41

ACBD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACBD3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M226332:  view genomic region     (about GC identifiers)

Start:
 226,332,380 bp from pter      End:
 226,374,431 bp from pter
Size:
 42,052 bases      Orientation:
 minus strand

Proteins
for ACBD3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GCP60_HUMAN, Q9H3P7 (See protein sequence)
Recommended Name: Golgi resident protein GCP60  
Size: 528 amino acids; 60593 Da
Subunit: Interacts with the C-terminal cytoplasmic domain of giantin/GOLGB1. Interacts with PBR and PKA regulatory
subunit RI-alpha. Does not interact with PKA regulatory subunit RI-beta nor PKA regulatory subunit RII-alpha (By
similarity)
Subcellular location: Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity).
Mitochondrion (By similarity). Note=Also mitochondrial (via its interaction with PBR) (By similarity)
Secondary accessions: B2RB29 Q5VTJ0 Q6P9F1 Q8IZC5 Q8N4D6 Q9H6U3

Explore the universe of human proteins at neXtProt for ACBD3: NX_Q9H3P7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H3P7

    • ACBD3 Protein expression data from MOPED and PaxDb:    About this image 
    ACBD3 Protein Expression
    REFSEQ proteins: NP_073572.2  
    ENSEMBL proteins: 
     ENSP00000355777  

    Human Recombinant Protein Products for ACBD3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ACBD3
    OriGene Protein Over-expression Lysate: ACBD3
    OriGene Custom Protein Services for ACBD3 
    GenScript Custom Purified and Recombinant Proteins Services for ACBD3
    Novus Biologicals ACBD3 Proteins
    Novus Biologicals ACBD3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ACBD3

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005739mitochondrion IEA--
    GO:0005794Golgi apparatus IDA--
    GO:0016021integral to membrane IEA--

    ACBD3 for ontologies           About GeneDecksing



    ACBD3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 7): ACBD3
    OriGene Custom Antibody Services for ACBD3 
    GenScript Custom Superior Antibodies Services for ACBD3
    Novus Biologicals ACBD3 Antibodies
    Abcam antibodies for ACBD3 
    Uscn Antibodies for ACBD3
    ThermoFisher Antibodies for ACBD3

    Assay Products for ACBD3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ACBD3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ACBD3

    Protein Domains /
    Families
    for ACBD3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ACBD3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR022408 Acyl-CoA-binding_prot_CS
     IPR009038 GOLD
     IPR000582 Acyl-CoA-binding_protein
     IPR014352 FERM/acyl-CoA-bd_prot_3-hlx

    Graphical View of Domain Structure for InterPro Entry Q9H3P7

    ProtoNet protein and cluster: Q9H3P7

    1 Blocks protein family: IPB000582 Acyl-coA-binding protein

    UniProtKB/Swiss-Prot: GCP60_HUMAN, Q9H3P7
    Domain: The GOLD domain is essential for giantin binding
    Similarity: Contains 1 ACB (acyl-CoA-binding) domain
    Similarity: Contains 1 GOLD domain


    Function
    for ACBD3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GCP60_HUMAN, Q9H3P7
    Function: Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport
    between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig
    cells (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000062fatty-acyl-CoA binding IEA--
         
    ACBD3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ACBD3:
     Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ACBD3 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: ACBD3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACBD3
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate ACBD3 (see all 16):
    hsa-miR-301b hsa-miR-34c-5p hsa-miR-449b hsa-miR-519e hsa-miR-301a hsa-miR-449a hsa-miR-3666 hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmid: ACBD3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACBD3 (see all 7)
    OriGene shRNA RFP: ACBD3
    OriGene siRNA: ACBD3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACBD3
    Sirion Biotech Custom design and validation of potent shRNA sequences against ACBD3 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ACBD3
    Sirion Biotech Customized adenovirus for overexpression of ACBD3 
    Sirion Biotech Customized adenovirus for potent knockdown of ACBD3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACBD3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACBD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ACBD3 (NM_022735)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACBD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACBD3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ACBD3
    Search LifeMap BioReagents cell lines for ACBD3
    Sirion Biotech Customized stable knockdown cell line services for ACBD3 
    Sirion Biotech Customized inducible knockdown cell line services for ACBD3
    Sirion Biotech Customized stable overexpressing cell line services for ACBD3
    Sirion Biotech Customized inducible overexpressing cell line services for ACBD3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACBD3


    Pathways & Interactions
    for ACBD3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Benzodiazepine Pathway, Pharmacodynamics
    		Benzodiazepine Pathway, Pharmacodynamics1.00


    1 PharmGKB Pathway for ACBD3
        Benzodiazepine Pathway, Pharmacodynamics

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ACBD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/13 Interacting proteins for ACBD3 (Q9H3P72, 3 ENSP000003557774) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMURF2Q9HAU42, 3MINT-61799 I2D: score=3 
    PI4KBQ9UBF82MINT-8379921 MINT-8379963 MINT-8379946 MINT-8379976
    GOLGB1Q147893, ENSP000003418484I2D: score=3 STRING: ENSP00000341848
    GOLGA3Q083783, ENSP000002047264I2D: score=1 STRING: ENSP00000204726
    MKNK1Q9BUB53I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006694steroid biosynthetic process IEA--
    GO:0006810transport IEA--

    ACBD3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ACBD3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ACBD3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACBD3

    10/32 HMDB Compounds for ACBD3 (see all 32)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--
    3 Novoseek chemical compound relationships for ACBD3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    benzodiazepine 76.8 13 11731621 (1), 20043945 (1), 12943713 (1), 12711385 (1) (see all 6)
    steroid 52.5 11 11731621 (3), 12943713 (2), 12711385 (2), 12692076 (1) (see all 5)
    cholesterol 32.5 8 12943713 (2), 11731621 (1), 17050526 (1), 19286473 (1)

    Search CenterWatch for drugs/clinical trials and news about ACBD3 / GCP60 

    Transcripts
    for ACBD3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ACBD3 gene: 
    NM_022735.3  

    Unigene Cluster for ACBD3:

    Acyl-CoA binding domain containing 3
    Hs.520207  [show with all ESTs]
    Unigene Representative Sequence: AB043587
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366812(uc001hpy.3) ENST00000464927

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ACBD3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACBD3
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate ACBD3 (see all 16):
    hsa-miR-301b hsa-miR-34c-5p hsa-miR-449b hsa-miR-519e hsa-miR-301a hsa-miR-449a hsa-miR-3666 hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmid: ACBD3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACBD3 (see all 7)
    OriGene shRNA RFP: ACBD3
    OriGene siRNA: ACBD3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACBD3
    Sirion Biotech Custom design and validation of potent shRNA sequences against ACBD3 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACBD3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACBD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ACBD3 (NM_022735)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACBD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACBD3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACBD3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACBD3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACBD3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACBD3

    Additional cDNA sequence: 

    AB043587.2 AK025520.1 AK314468.1 BC034563.2 BC039575.1 BC045533.1 BC060792.1 

    7 DOTS entries:

    DT.415758  DT.95182169  DT.95376411  DT.100026620  DT.100692533  DT.100754839  DT.121374686 

    24/214 AceView cDNA sequences (see all 214):

    BQ020219 AI245872 BQ431349 AL558223 BQ632415 AI014575 AI738902 AI636211 
    CA394672 BM801531 AK025520 BU153320 AA926728 AI374834 BF197549 CA771017 
    NM_022735 BE048884 N90029 AI674869 AL546667 CR590509 BG028747 BM975030 

    GeneLoc Exon Structure


    Expression
    for ACBD3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACBD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGTTAGGCA
    ACBD3 Expression
    About this image
    See ACBD3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACBD3

    SOURCE GeneReport for Unigene cluster: Hs.520207

    UniProtKB/Swiss-Prot: GCP60_HUMAN, Q9H3P7
    Tissue specificity: Ubiquitous, with highest expression in testis and ovary

        SABiosciences Custom PCR Arrays for ACBD3
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACBD3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACBD3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACBD3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACBD3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACBD3

    Orthologs
    for ACBD3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ACBD3 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ACBD31 acyl-CoA binding domain containing 3 80.04(n)
    85.66(a)    		   421317  NM_001031043.1  NP_001026214.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ACBD36
    		 --
    		 82(a)
    		 1 ↔ 1
    		 1(251507794-251534472)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BJ040833.12   -- 79.01(n)    BJ040833.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BU492952.12   -- 74.36(n)   321222  BU492952.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG142321 CG14232 50.26(n)
    44.15(a)    		   32983  NM_134504.3  NP_608348.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea CELE_Y41E3.71 Protein Y41E3.7 54.39(n)
    49.37(a)    		   178416  NM_001047560.1  NP_001041025.1 


    ENSEMBL Gene Tree for ACBD3 (if available)
    TreeFam Gene Tree for ACBD3 (if available) 

    Paralogs
    for ACBD3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACBD3 gene
    TMED82  

    ACBD3 for paralogs           About GeneDecksing



    Genomic Variants
    for ACBD3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/710 NCBI SNPs in ACBD3 are shown (see all 710)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs97272551,2
    		C,F,A,H--196849142(+) TCCACA/GTCACA 1 -- ds500113Minor allele frequency- G:0.08NS EA NA WA CSA 1309
    rs10436411,2
    		C,F,O,H--196850159(-) TAACTG/ACAGTA 1 -- ut31 ese328Minor allele frequency- A:0.12NA EA MN NS WA 3156
    rs413040041,2
    		C,F--196850366(+) NNNNAG/ATAAGG 1 -- ut311Minor allele frequency- A:0.03NA 120
    rs413142881,2
    		--196850530(+) GAAAAC/TAGACT 1 -- ut310--------
    rs178557151,2
    		H--196851641(+) AAGGCT/CTGTTG 2 /K /R mis1 ese34Minor allele frequency- C:0.00NS EA 420
    rs413033091,2
    		C,F--196851766(+) TTTTTT/CTTCTG 1 -- int13Minor allele frequency- C:0.08NA CSA 124
    rs1167823461,2
    		C,F--196852712(+) TCACAG/ATNNNN 1 -- int11Minor allele frequency- A:0.03NA 120
    rs2021054661,2
    		C--196852803(+) TTTTTG/TTNNNN 1 -- int10--------
    rs283686141,2
    		C,F--196854693(+) GCCACC/TGTGCC 1 -- int12Minor allele frequency- T:0.05WA NA 238
    rs1134335661,2
    		C--196855133(+) CAAAAC/TGGGTT 1 -- int11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for ACBD3 (226332380 - 226374431 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ACBD3
         1 CNV: 58366

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACBD3
    DNA2.0 Custom Variant and Variant Library Synthesis for ACBD3

    Disorders / Diseases
    for ACBD3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ACBD3 for disorders           About GeneDecksing

    OMIM gene information: 606809    OMIM disorders: --

    3 diseases for ACBD3:    About MalaCards
    carney complex    cholesterol    neuronitis

    1 Novoseek disease relationship for ACBD3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypercortisolism 67 2 12943713 (1), 12692076 (1)

    Human Genome Epidemiology (HuGE) Navigator: ACBD3 (2 documents)

    Export disorders for ACBD3 gene to outside databases

    Publications
    for ACBD3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACBD3 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with ACBD3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    5. Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin. (PubMed id 11590181)1, 2 Sohda M.... Ikehara Y. (2001)
    6. Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein. (PubMed id 11731621)1, 9 Li H....Papadopoulos V. (2001)
    7. Molecular cloning, genomic organization, chromosomal mapping and subcellular localization of mouse PAP7: a PBR and PKA-RIalpha associated protein. (PubMed id 12711385)1, 9 Liu J....Papadopoulos V. (2003)
    8. Molecular cloning, chromosomal localization of human peripheral-type benzodiazepine receptor and PKA regulatory subunit type 1A (PRKAR1A)-associated protein PAP7, and studies in PRKAR1A mutant cells and tissues. (PubMed id 12692076)1, 9 Liu J....Papadopoulos V. (2003)
    9. Acyl-CoA binding domain containing 3 (ACBD3) recruits the protein phosphatase PPM1L to ER-Golgi membrane contact sites. (PubMed id 22796112)1 Shinoda Y....Kobayashi T. (2012)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    External Searches for ACBD3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ACBD3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64746 HGNC: 15453 AceView: ACBD3 Ensembl:ENSG00000182827 euGenes: HUgn64746
    ECgene: ACBD3 H-InvDB: ACBD3

    Other Databases showing ACBD3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ACBD3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACBD3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ACBD3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ACBD3 gene:
    Search GeneIP for patents involving ACBD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ACBD3 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for ACBD3   OriGene shRNA RFP for ACBD3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACBD3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACBD3  
     OriGene Protein Over-expression Lysate for ACBD3   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ACBD3   OriGene 3'-UTR Clone for ACBD3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACBD3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACBD3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for ACBD3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ACBD3   OriGene Custom Protein Services for ACBD3  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ACBD3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACBD3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACBD3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACBD3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACBD3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACBD3
     GenScript Custom Purified and Recombinant Proteins Services for ACBD3 GenScript cDNA clones with any tag delivered in your preferred vector for ACBD3
     GenScript Custom Assay Services for ACBD3 GenScript Custom Superior Antibodies Services for ACBD3
     GenScript Custom overexpressing Cell Line Services for ACBD3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ACBD3 promoter
     Search Chromatin IP Primers for ACBD3
     RT2 qPCR Primer Assay in human, mouse, rat ACBD3
     GNC Network for ACBD3
     SABiosciences Custom PCR Arrays for ACBD3
     Search Tocris compounds for ACBD3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ACBD3 antibodies
     ACBD3 proteins
     ACBD3 lysates
     Antibodies for ACBD3
     See all of Abcam's Antibodies, Kits and Proteins for ACBD3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ACBD3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ACBD3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACBD3
     SwitchGear 3'UTR luciferase reporter plasmids for ACBD3
     SwitchGear Promoter luciferase reporter plasmids for ACBD3
     ThermoFisher Antibodies for ACBD3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACBD3
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ACBD3
    Sirion Biotech Customized:
     stable knockdown cell line services for ACBD3
     inducible knockdown cell line services for ACBD3
     design and validation of potent shRNA sequences against ACBD3
     adenovirus for potent knockdown of ACBD3
     adenovirus for overexpression of ACBD3
     stable overexpressing cell line services for ACBD3
     inducible overexpressing cell line services for ACBD3
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ACBD3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4