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ACAT2 Gene

protein-coding GIFtS: 66

GC06P160153

acetyl-Coenzyme A acetyltransferase 2
(Previous name: acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ACTL ^³
EC 2.3.1.9 ^³
OTTHUMP00000017527 ^²

Descriptions
Acetyl-CoA transferase-like protein ^³
Cytosolic acetoacetyl-CoA thiolase ^², ³
acetoacetyl Coenzyme A thiolase ^²
acetyl-Coenzyme A acetyltransferase 2 ^²
acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) ^¹

External Ids
HGNC: 94¹
Entrez Gene: 39²
UniProtKB: Q9BWD1³
Ensembl: ENSG00000120437⁷

Search outside databases for aliases for ACAT2 gene

Previous GC identifers: GC06P159622 GC06P160056 GC06P160015 GC06P160092

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for ACAT2:

The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic

acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the

TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as

in opposite transcriptional orientation. [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ACAT2 gene

Entrez Gene cytogenetic band: 6q25.3 Ensembl cytogenetic band: 6q25.3 HGNC cytogenetic band: 6q25.3-q26

ACAT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P160153: (about GC identifiers)

Start:	160,102,979 bp from pter
End:	160,120,077 bp from pter
Size:	17,099 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000006.10 NT_007422.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: THIC_HUMAN, Q9BWD1 (See protein sequence)

Recommended Name: Acetyl-CoA acetyltransferase, cytosolic

Size: 397 amino acids; 41351 Da

Subunit: Homotetramer

Subcellular location: Cytoplasm

PDB structure from and Proteopedia :

1WL4 (3D)

1WL5 (3D)

Secondary accessions: Q16146 Q5TCL7 Q8TDM4

REFSEQ proteins: NP_005882.2

ENSEMBL proteins:

ENSP00000356015

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ACAT2)
	Human Recombinant Proteins from Abnova (ACAT2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	TAS	7911016

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Antibodies for ACAT2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ACAT2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ACAT2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ACAT2)
	Novus Biologicals Antibodies for ACAT2

Assays for ACAT2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9BWD1

ProtoNet protein and cluster: Q9BWD1

1 Blocks protein family: IPB002155 Thiolase

UniProtKB/Swiss-Prot: THIC_HUMAN, Q9BWD1

Similarity: Belongs to the thiolase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACAT2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ACAT2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005891

Applied Biosystems Silencer® siRNAs for ACAT2

Sigma-Aldrich siRNA and siRNA Panels for ACAT2

Sigma-Aldrich shRNA for ACAT2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ACAT2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005891
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005891
untagged cDNA clone in CMV expression vector: NM_005891

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005891

UniProtKB/Swiss-Prot: THIC_HUMAN, Q9BWD1

Catalytic activity: 2 acetyl-CoA = CoA + acetoacetyl-CoA

Enzyme Number (IUBMB): EC 2.3.1.9

Genatlas biochemistry entry for ACAT2:

acetoacetyl-CoA thiolase 2,cytosolic,overlapping in opposite orientation,the 3' region of t complex

1 (TCP1)

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003985	acetyl-CoA C-acetyltransferase activity	IEA	--
GO:0005515	protein binding	IPI	17353931
GO:0008415	acyltransferase activity	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/8 Sigma-Aldrich "Your Favorite Gene" Pathways for ACAT2 (Your Favorite Gene powered by Ingenuity) (see all 8 )

Butanoate Metabolism
Pyruvate Metabolism
Valine, Leucine and Isoleucine Degradation
Fatty Acid Metabolism
Tryptophan Metabolism

GeneDecks ACAT2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ACAT2

5/36 Interacting proteins for ACAT2 (ENSP00000356015³ Q9BWD1¹) via UniProtKB, MINT, and/or STRING (see all 36 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GNAS	P63092¹	EBI-1047273, EBI-1047114
HADH	ENSP00000265168³	STRING (score=.956)
AACS	ENSP00000324842³	STRING (score=.955)
ACSS1	ENSP00000316924³	STRING (score=.946)
ACSS2	ENSP00000363825³	STRING (score=.946)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	TAS	7911016
GO:0008152	metabolic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Enzo Life Sciences drugs & compounds for ACAT2

Browse Small Molecules at Sigma-Aldrich

Compounds for ACAT2 available from Tocris Bioscience

Compound	Action	CAS number
CI 976	Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor	[114289-47-3]
VULM 1457	Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor	[228544-65-8]

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4 Novoseek chemical compound relationships for ACAT2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
acetoacetyl coa	88.40	8	9607396 (2), 9380443 (2), 8812443 (1), 15733928 (1) (see all 5)
acetyl-coa	65.09	2	11283790 (1), 10353914 (1)
cholesterol	34.06	10	15451793 (4), 17438337 (3), 18340009 (2), 16331323 (1)
lipid	0.00	1	10353914 (1)

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1 PharmGKB drug compound relationship for ACAT2 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
clozapine	PD	15121641

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACAT2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ACAT2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005891

Sigma-Aldrich siRNA and siRNA Panels for ACAT2

Sigma-Aldrich shRNA for ACAT2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005891

REFSEQ mRNAs for ACAT2 gene:

NM_005891.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005891

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005891
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005891
                                 untagged cDNA clone in CMV expression vector: NM_005891

Additional cDNA sequence:

AB208993.1 AF356877.1 AK225089.1 AK225244.1 AK291080.1 AK294273.1 BC000408.2 CR590182.1

CR592880.1 CR602774.1 CR603383.1 CR605843.1 CR616356.1 CR617627.1 S70154.1

24/34 DOTS entries (see all 34 ):

DT.99989299 DT.121326816 DT.100828792 DT.100759125 DT.87079575 DT.100884457 DT.86852813 DT.121326761

DT.91782029 DT.75133091 DT.100764164 DT.100884461 DT.100884486 DT.91782027 DT.119861 DT.121326756

DT.121326882 DT.121326906 DT.91782015 DT.100031509 DT.100031512 DT.102839912 DT.121326956 DT.121327003

24/438 AceView cDNA sequences (see all 438 ):

BM549699 BQ648344 BF128856 BQ718511 BU149746 AA341050 BQ050667 BF795373

BI756309 CR602774 BQ677567 BQ050939 BQ684278 CB109303 D20985 BQ680061

F06359 CR592880 BQ676524 BM760441 BM905050 CR605843 BE796920 BE794798

highest scoring ESTs for ACAT2:

AA262195 AK055001 BE748830 BF306004 BG108319 BG163370 BG742275 BQ644991 BQ651311 BQ679097

Unigene Cluster for ACAT2:

Acetyl-Coenzyme A acetyltransferase 2

Hs.571037 [show with all ESTs]

Unigene Representative Sequence: AK294273

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ACAT2 (see all 11 )

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	·	6c	·	6d	·	6e	·	6f	·	6g	^	7	^	8a	·	8b	^	9
SP1:					-		-		-		-								-				-		-
SP2:					-		-		-		-								-				-
SP3:																			-				-		-
SP4:																			-				-		-
SP5:																			-				-		-

About this scheme

ECgene alternative splicing isoforms for ACAT2

1 Ensembl transcript including schematic representation:

ENST00000367048

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ACAT2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ACAT2

¹ / ² / ³

3 probe-sets matching ACAT2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34790_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	S70154	0.80	1.00	0.91	1
209608_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC000408	0.60	0.75	0.68	1
209608_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ACAT2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCCAAGCTAA

SOURCE GeneReport for Unigene cluster: Hs.571037
Expression variation in blood from EXPOLDB for ACAT2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ACAT2 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ACAT2¹	--	acetyl-Coenzyme A acetyltransferase 2	89(n) 89.95(a)	484063 XM_541180.2 XP_541180.2
cow (Bos taurus)	ACAT2¹	--	acetyl-Coenzyme A acetyltransferase 2	88.8(n) 89.9(a)	512044 NM_001075549.1 NP_001069017.1
rat (Rattus norvegicus)	Acat2¹	--	acetyl-Coenzyme A acetyltransferase 2	85.02(n) 87.37(a)	308100 NM_001006995.1 NP_001006996.1
mouse (Mus musculus)	Acat2^{1, 5}	17 (7.55 cM)⁵	acetyl-Coenzyme A acetyltransferase 2^{1, 5}	86.03(n)¹ 87.63(a)¹	110460¹ NM_009338.2¹ NP_033364.1¹ AK037249⁵ AK151751⁵ (see all 11)
chicken (Gallus gallus)	ACAT2¹	--	acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl more	71.65(n) 72.43(a)	421587 NM_001039287.1 NP_001034376.1

About this table Species with no ortholog for ACAT2

ENSEMBL Gene Tree for ACAT2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ACAT2 gene

ACAT1² ACAA2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/75 NCBI SNPs in ACAT2 are shown (see all 75 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 66)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs25683^1,2	C,F,H	160116333(+)	`TAGAAA/GAGGTG`	1	K/R	mis¹		15	MN EA EU WA NA	2824
	rs3465^1,2	C,F,H	160118385(+)	`CGTGGG/ACTTAC`	1	G/G	syn¹ ese³		18	MN EA NA EU WA	1750
--	rs3464^1,2	C,F	160118349(+)	`GCTGTC/TGTTCT`	1	V/V	syn¹		13	MN EA NA NS	1300
--	rs41292466^1,2	F	160116286(+)	`AAAGCT/GGGCCA`	1	A/A	syn¹		6	NS	664
	rs11751480^1,2	A,C,F,H	160117566(+)	`ATTATT/CCTTAA`	1	--	int¹		4	EU EA WA	396
	rs7759086^1,2	A,C,F,H	160113843(+)	`aaaaaG/AaaaGA`	1	--	int¹ trp³		4	EU EA WA	418
	rs9355749^1,2	A,C,F,H	160115195(+)	`tggcaG/Caatct`	1	--	int¹		10	EU EA WA NS	1078
	rs9347343^1,2	A,F,H	160113368(+)	`tacctA/Ttaaag`	1	--	int¹		4	EU EA WA	418
	rs3798212^1,2	A,C,F	160106862(-)	`TATCAA/GTCTGG`	1	--	int¹		7	EA NS	2162
	rs7758895^1,2	C,F,H	160113455(+)	`atgctC/Tgtttt`	1	--	int¹		4	EU EA WA	408

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HapMap Linkage Disequilibrium images for ACAT2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 100678

1 Novoseek disease relationship for ACAT2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
atherosclerosis	24.19	3	14615411 (1), 15451793 (1)

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1 PharmGKB disease relationship for ACAT2 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Schizophrenia	PD	15121641

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Human Gene Mutation Database: ACAT2
Genetic Association Database: ACAT2
Human Genome Epidemiology Navigator: ACAT2 (9 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/41 PubMed articles for ACAT2 gene (see all 41 ):

High resolution crystal structures of human cytosolic thiolase (CT): a comparison of the active sites of human CT, bacterial thiolase, and bacterial KAS I. (PubMed id 15733928)^{1, 3, 4} Kursula P.... Wierenga R.K. (2005)
Molecular cloning and nucleotide sequence of complementary DNA for human hepatic cytosolic acetoacetyl-coenzyme A thiolase. (PubMed id 7911016)^{1, 3, 4} Song X.-Q....Orii T. (1994)
Acyl-CoA: cholesterol acyltransferase-2 gene polymorphisms and their association with plasma lipids and coronary artery disease risks. (PubMed id 16195894)^{3, 6} He X....Heng C.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The influence of the acyl-CoA:cholesterol acyltransferase-1 gene (-77G-->A) polymorphisms on plasma lipid and apolipoprotein levels in normolipidemic and hyperlipidemic subjects. (PubMed id 15158756)^{3, 6} Ohta T....Fukuyama S. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{3, 4} Mungall A.J.... Beck S. (2003)
Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients. (PubMed id 14557872)^{3, 6} McCarthy J.J....Topol E.J. (2003)
Effects of a new single-nucleotide polymorphism in the Acyl-CoA:cholesterol acyltransferase-2 gene on plasma lipids and apolipoproteins in patients with hyperlipidemia. (PubMed id 12621162)^{3, 6} Katsuren K....Ohta T. (2003)
Transcript encoded on the opposite strand of the human steroid 21- hydroxylase/complement component C4 gene locus. (PubMed id 2475872)^{2, 3} Morel Y.... Miller W.L. (1989)
Assignment of the human cytosolic acetoacetyl-coenzyme A thiolase (ACAT2) gene to chromosome 6q25.3-q26. (PubMed id 8812443)^{1, 3} Masuno M....Kuroki Y. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 39	HGNC: 94	AceView: ACAT2	Ensembl:ENSG00000120437	euGenes: HUgn39
ECgene: ACAT2	H-InvDB: ACAT2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ACAT2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ACAT2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ACAT2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ACAT2		Antibodies for ACAT2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ACAT2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ACAT2)
	Antibodies (ACAT2)
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	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Tocris compounds for ACAT2

	Drugs for ACAT2
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ACAT2

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ACAT2 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for ACAT2

Summaries
for ACAT2

Genomic Location
for ACAT2

Proteins
for ACAT2

Protein Domains/
Families
for ACAT2

Gene Function
for ACAT2

Pathways & Interactions
for ACAT2

Drugs & Compounds
for ACAT2

Transcripts
for ACAT2

Expression
for ACAT2

Orthologs
for ACAT2

Paralogs
for ACAT2

SNPs/Variants
for ACAT2

Disorders & Mutations
for ACAT2

Medical News
for ACAT2

Publications
for ACAT2

Search for ACAT2

Genome Databases showing ACAT2

Other Databases showing ACAT2

Specialized Databases showing ACAT2

Licensable Technologies
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Services
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ACAT2 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor ACAT2

Summariesfor ACAT2

Genomic Locationfor ACAT2

Proteinsfor ACAT2

Protein Domains/Familiesfor ACAT2

Gene Functionfor ACAT2

Pathways & Interactionsfor ACAT2

Drugs & Compoundsfor ACAT2

Transcriptsfor ACAT2

Expression for ACAT2

Orthologsfor ACAT2

Paralogsfor ACAT2

SNPs/Variantsfor ACAT2

Disorders & Mutationsfor ACAT2

Medical Newsfor ACAT2

Publicationsfor ACAT2

Search for ACAT2

Genome Databases showing ACAT2

Other Databases showing ACAT2

Specialized Databases showing ACAT2

Licensable Technologiesfor ACAT2

Servicesfor ACAT2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ACAT2

Summaries
for ACAT2

Genomic Location
for ACAT2

Proteins
for ACAT2

Protein Domains/
Families
for ACAT2

Gene Function
for ACAT2

Pathways & Interactions
for ACAT2

Drugs & Compounds
for ACAT2

Transcripts
for ACAT2

Expression
for ACAT2

Orthologs
for ACAT2

Paralogs
for ACAT2

SNPs/Variants
for ACAT2

Disorders & Mutations
for ACAT2

Medical News
for ACAT2

Publications
for ACAT2

Licensable Technologies
for ACAT2

Services
for ACAT2