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Aliases for ACAT2 Gene

Aliases for ACAT2 Gene

  • Acetyl-CoA Acetyltransferase 2 2 3
  • EC 4 63
  • Acetyl-Coenzyme A Acetyltransferase 2 (Acetoacetyl Coenzyme A Thiolase) 2
  • Acetyl-Coenzyme A Acetyltransferase 2 2
  • Acetyl-CoA Transferase-Like Protein 4
  • Cytosolic Acetoacetyl-CoA Thiolase 4
  • Acetoacetyl Coenzyme A Thiolase 2
  • EC 2.3.1 63
  • ACTL 4

External Ids for ACAT2 Gene

Previous GeneCards Identifiers for ACAT2 Gene

  • GC06P159622
  • GC06P160056
  • GC06P160015
  • GC06P160092
  • GC06P160153
  • GC06P157652
  • GC06P160182

Summaries for ACAT2 Gene

Entrez Gene Summary for ACAT2 Gene

  • The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for ACAT2 Gene

ACAT2 (Acetyl-CoA Acetyltransferase 2) is a Protein Coding gene. Diseases associated with ACAT2 include acat2 deficiency and thiolase deficiency. Among its related pathways are Metabolism and Glucose / Energy Metabolism. GO annotations related to this gene include acetyl-CoA C-acetyltransferase activity. An important paralog of this gene is ACAA2.

Gene Wiki entry for ACAT2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACAT2 Gene

Genomics for ACAT2 Gene

Regulatory Elements for ACAT2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ACAT2 Gene

159,760,328 bp from pter
159,779,055 bp from pter
18,728 bases
Plus strand

Genomic View for ACAT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACAT2 Gene

Proteins for ACAT2 Gene

  • Protein details for ACAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acetyl-CoA acetyltransferase, cytosolic
    Protein Accession:
    Secondary Accessions:
    • B7Z233
    • E1P5B1
    • Q16146
    • Q5TCL7
    • Q8TDM4

    Protein attributes for ACAT2 Gene

    397 amino acids
    Molecular mass:
    41351 Da
    Quaternary structure:
    • Homotetramer

    Three dimensional structures from OCA and Proteopedia for ACAT2 Gene

    Alternative splice isoforms for ACAT2 Gene


neXtProt entry for ACAT2 Gene

Proteomics data for ACAT2 Gene at MOPED

Selected DME Specific Peptides for ACAT2 Gene

Post-translational modifications for ACAT2 Gene

  • Ubiquitination at Lys124 and Lys235
  • Modification sites at PhosphoSitePlus

Other Protein References for ACAT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ACAT2 (ACAT2)

Domains for ACAT2 Gene

Protein Domains for ACAT2 Gene

Suggested Antigen Peptide Sequences for ACAT2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the thiolase family.
  • Belongs to the thiolase family.
genes like me logo Genes that share domains with ACAT2: view

No data available for Gene Families for ACAT2 Gene

Function for ACAT2 Gene

Molecular function for ACAT2 Gene

GENATLAS Biochemistry:
acetoacetyl-CoA thiolase 2,cytosolic,overlapping in opposite orientation,the 3 region of t complex 1 (TCP1)
UniProtKB/Swiss-Prot CatalyticActivity:
2 acetyl-CoA = CoA + acetoacetyl-CoA.

Enzyme Numbers (IUBMB) for ACAT2 Gene

Gene Ontology (GO) - Molecular Function for ACAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0003985 acetyl-CoA C-acetyltransferase activity IDA 7911016
GO:0005515 protein binding IPI 25416956
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups --
genes like me logo Genes that share ontologies with ACAT2: view

Animal Model Products

miRNA for ACAT2 Gene

miRTarBase miRNAs that target ACAT2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACAT2

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for ACAT2 Gene

Localization for ACAT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACAT2 Gene


Subcellular locations from

Jensen Localization Image for ACAT2 Gene COMPARTMENTS Subcellular localization image for ACAT2 gene
Compartment Confidence
mitochondrion 4
nucleus 4
cytosol 3
peroxisome 2
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ACAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with ACAT2: view

Pathways for ACAT2 Gene

genes like me logo Genes that share pathways with ACAT2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ACAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IC 7911016
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with ACAT2: view

Drugs for ACAT2 Gene

(2) Drugbank Compounds for ACAT2 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
165339 Target experimental
Coenzyme A
  • 3'-phosphoadenosine-(5')diphospho(4')pantatheine
85-61-0 46936280 Target nutraceutical

(5) HMDB Compounds for ACAT2 Gene

Compound Synonyms Cas Number PubMed IDs
  • 3-Ketohexanoyl CoA.
  • 3-Acetoacetyl-CoA
  • Ac-CoA
  • Butanoyl-CoA
Coenzyme A
  • Acetoacetyl coenzyme A sodium salt

(4) Novoseek inferred chemical compound relationships for ACAT2 Gene

Compound -log(P) Hits PubMed IDs
acetoacetyl coa 87.8 7
acetyl-coa 63.6 2
cholesterol 36.7 13
lipid 0 1
genes like me logo Genes that share compounds with ACAT2: view

Transcripts for ACAT2 Gene

mRNA/cDNA for ACAT2 Gene

Unigene Clusters for ACAT2 Gene

Acetyl-CoA acetyltransferase 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACAT2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACAT2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g ^ 7 ^ 8a · 8b ^ 9
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5: - - -
SP6: - -
SP7: - - - -
SP9: - - - -
SP10: -

Relevant External Links for ACAT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACAT2 Gene

mRNA expression in normal human tissues for ACAT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ACAT2 Gene

This gene is overexpressed in Testis (9.6), Fetal testis (9.4), Fetal Liver (7.4), and Liver, secretome (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACAT2 Gene

SOURCE GeneReport for Unigene cluster for ACAT2 Gene Hs.571037

genes like me logo Genes that share expressions with ACAT2: view

Expression partners for ACAT2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ACAT2 Gene

Orthologs for ACAT2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACAT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ACAT2 35
  • 88.8 (n)
  • 89.9 (a)
ACAT2 36
  • 90 (a)
(Canis familiaris)
Mammalia ACAT2 35
  • 89.14 (n)
  • 90.15 (a)
ACAT2 36
  • 88 (a)
(Mus musculus)
Mammalia Acat2 35
  • 86.11 (n)
  • 87.88 (a)
Acat2 16
Acat2 36
  • 88 (a)
Acat3 36
  • 86 (a)
(Pan troglodytes)
Mammalia ACAT2 35
  • 99.5 (n)
  • 99.24 (a)
ACAT2 36
  • 90 (a)
(Rattus norvegicus)
Mammalia Acat2 35
  • 85.02 (n)
  • 87.37 (a)
(Monodelphis domestica)
Mammalia ACAT2 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia ACAT2 36
  • 72 (a)
(Gallus gallus)
Aves ACAT2 35
  • 73.13 (n)
  • 74.49 (a)
ACAT2 36
  • 75 (a)
(Anolis carolinensis)
Reptilia ACAT2 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia acat2 35
  • 69.87 (n)
  • 73.48 (a)
MGC76038 35
African clawed frog
(Xenopus laevis)
Amphibia ACAT2 35
(Danio rerio)
Actinopterygii -- 35
acat2 35
  • 68.62 (n)
  • 71.76 (a)
acat2 36
  • 72 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.356 35
fruit fly
(Drosophila melanogaster)
Insecta CG9149 37
  • 52 (a)
CG9149 35
  • 55.81 (n)
  • 58.14 (a)
CG9149 36
  • 57 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001318 35
  • 56.74 (n)
  • 58.03 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERG10 36
  • 42 (a)
Species with no ortholog for ACAT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACAT2 Gene

Gene Tree for ACAT2 (if available)
Gene Tree for ACAT2 (if available)

Paralogs for ACAT2 Gene

Paralogs for ACAT2 Gene

(4) SIMAP similar genes for ACAT2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ACAT2: view

Variants for ACAT2 Gene

Sequence variations from dbSNP and Humsavar for ACAT2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs553401944 -- 159,768,890(+) CCACA(A/G)ATAGT intron-variant
rs553465740 -- 159,773,244(+) CAAAA(A/T)GCAGT intron-variant
rs553516495 -- 159,765,367(+) CGCCT(C/T)GGCCT intron-variant
rs553620997 -- 159,765,814(+) ACCCG(G/T)TTTTA intron-variant
rs553773954 -- 159,764,601(+) CACCA(C/T)ACCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACAT2 Gene

Variant ID Type Subtype PubMed ID
dgv2023e1 CNV Complex 17122850
nsv5563 CNV Insertion 18451855

Relevant External Links for ACAT2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACAT2 Gene

Disorders for ACAT2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ACAT2 Gene in MalaCards »

(3) Diseases for ACAT2 Gene

(1) OMIM Diseases for ACAT2 Gene (100678)

(1) University of Copenhagen DISEASES for ACAT2 Gene

(1) Novoseek inferred disease relationships for ACAT2 Gene

Disease -log(P) Hits PubMed IDs
atherosclerosis 22 2

Relevant External Links for ACAT2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ACAT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACAT2 Gene

Publications for ACAT2 Gene

  1. High resolution crystal structures of human cytosolic thiolase (CT): a comparison of the active sites of human CT, bacterial thiolase, and bacterial KAS I. (PMID: 15733928) Kursula P. … Wierenga R.K. (J. Mol. Biol. 2005) 3 4 23
  2. Molecular cloning and nucleotide sequence of complementary DNA for human hepatic cytosolic acetoacetyl-coenzyme A thiolase. (PMID: 7911016) Song X.-Q. … Orii T. (Biochem. Biophys. Res. Commun. 1994) 3 4 23
  3. Two human ACAT2 mRNA variants produced by alternative splicing and coding for novel isoenzymes. (PMID: 16331323) Yao X.M. … Li B.L. (Acta Biochim. Biophys. Sin. (Shanghai) 2005) 3 23
  4. Assignment of the human cytosolic acetoacetyl-coenzyme A thiolase (ACAT2) gene to chromosome 6q25.3-q26. (PMID: 8812443) Masuno M. … Kuroki Y. (Genomics 1996) 3 23
  5. Transcript encoded on the opposite strand of the human steroid 21- hydroxylase/complement component C4 gene locus. (PMID: 2475872) Morel Y. … Miller W.L. (Proc. Natl. Acad. Sci. U.S.A. 1989) 2 3

Products for ACAT2 Gene

Sources for ACAT2 Gene

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