V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

ACAT1 Gene

protein-coding GIFtS: 68

GC11P107499

acetyl-Coenzyme A acetyltransferase 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ACAT)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ACAT ^², ³
EC 2.3.1.9 ^³
MAT ^², ³
T2 ^², ³
THIL ^¹, ²

Descriptions
Acetoacetyl-CoA thiolase ^³
acetoacetyl Coenzyme A thiolase ^²
acetyl-Coenzyme A acetyltransferase 1 ^²
mitochondrial acetoacetyl-CoA thiolase ^²

External Ids
HGNC: 93¹
Entrez Gene: 38²
UniProtKB: P24752³
Ensembl: ENSG00000075239⁷

Search outside databases for aliases for ACAT1 gene

Previous GC identifers: GC11P110186 GC11P109348 GC11P108026 GC11P107529

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ACAT1:

This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of

acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with

3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary

excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and

butanone. [provided by RefSeq]

UniProtKB/Swiss-Prot: THIL_HUMAN, P24752

Function: Plays a major role in ketone body metabolism

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ACAT1 gene

Entrez Gene cytogenetic band: 11q22.3-q23.1 Ensembl cytogenetic band: 11q22.3 HGNC cytogenetic band: 11q22.3

ACAT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P107499: (about GC identifiers)

Start:	107,497,468 bp from pter
End:	107,523,485 bp from pter
Size:	26,018 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_033899.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: THIL_HUMAN, P24752 (See protein sequence)

Recommended Name: Acetyl-CoA acetyltransferase, mitochondrial precursor

Size: 427 amino acids; 45200 Da

Subunit: Homotetramer

Subcellular location: Mitochondrion

PDB structures from and Proteopedia :

2F2S (3D)

2IB7 (3D)

2IB8 (3D)

2IB9 (3D)

2IBU (3D)

2IBW (3D)

2IBY (3D)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000010.1

ENSEMBL proteins:

ENSP00000265838 ENSP00000364826 ENSP00000299355

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ACAT1)
	Human Recombinant Proteins from Abnova (ACAT1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	TAS	1715688
GO:0005759	mitochondrial matrix	EXP	3709573

About this table

Antibodies for ACAT1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ACAT1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ACAT1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ACAT1)
	Novus Biologicals Antibodies for THIL

Assays for ACAT1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P24752

ProtoNet protein and cluster: P24752

1 Blocks protein family: IPB002155 Thiolase

UniProtKB/Swiss-Prot: THIL_HUMAN, P24752

Similarity: Belongs to the thiolase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACAT1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC010942

Applied Biosystems Silencer® siRNAs for ACAT1

Sigma-Aldrich siRNA and siRNA Panels for ACAT1

Sigma-Aldrich shRNA for ACAT1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ACAT1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000019
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000019
untagged cDNA clones in CMV expression vector (see all 2): BC010942

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000019

UniProtKB/Swiss-Prot: THIL_HUMAN, P24752

Function: Plays a major role in ketone body metabolism

Catalytic activity: 2 acetyl-CoA = CoA + acetoacetyl-CoA

Enzyme regulation: Activated by potassium ions, but not sodium ions

Biophysicochemical properties: Kinetic parameters: KM=4 uM for acteoacetyl coenzyme A; KM=20 uM for

coenzyme A; KM=8 uM for 2-methylacteoacetyl coenzyme A; KM=508 uM for acetyl coenzyme A;

Enzyme Number (IUBMB): EC 2.3.1.9

Genatlas biochemistry entry for ACAT1:

acetoacetyl-CoA thiolase 1,branched chain,mitochondrial,isoleucine catabolism,fatty acid

beta-oxidation

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003985	acetyl-CoA C-acetyltransferase activity	TAS	1979337
GO:0005515	protein binding	IPI	17353931
GO:0016407	acetyltransferase activity	EXP	3709573
GO:0016740	transferase activity	IEA	--
GO:0030955	potassium ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/8 Sigma-Aldrich "Your Favorite Gene" Pathways for ACAT1 (Your Favorite Gene powered by Ingenuity) (see all 8 )

Valine, Leucine and Isoleucine Degradation
Butanoate Metabolism
Pyruvate Metabolism
Fatty Acid Metabolism
Synthesis and Degradation of Ketone Bodies

GeneDecks ACAT1 for the pathways selected above

About GeneDecksing

5/37 Interacting proteins for ACAT1 (P24752¹ ENSP00000265838³) via UniProtKB, MINT, and/or STRING (see all 37 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EIF1B	O60739¹	EBI-1051459, EBI-1043343
HADHA	ENSP00000370023³	STRING (score=.97)
HMGCL	ENSP00000363614³	STRING (score=.966)
AACS	ENSP00000324842³	STRING (score=.964)
HMGCS1	ENSP00000322706³	STRING (score=.962)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008152	metabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ACAT1

Browse Small Molecules at Sigma-Aldrich

Compounds for ACAT1 available from Tocris Bioscience

Compound	Action	CAS number
CI 976	Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor	[114289-47-3]
VULM 1457	Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor	[228544-65-8]

About this table

5 Novoseek chemical compound relationships for ACAT1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
acetoacetyl coa	98.20	61	17371050 (4), 15128923 (3), 8099727 (2), 17236799 (2) (see all 39)
isoleucine	69.04	7	17236799 (1), 11914035 (1), 15128923 (1), 14518824 (1) (see all 7)
acetyl-coa	35.40	2	11988101 (1), 16950638 (1)
potassium	20.21	6	17371050 (2), 15128923 (1), 1349518 (1), 8725269 (1)
cholesterol	0.00	3	9469584 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACAT1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC010942

Sigma-Aldrich siRNA and siRNA Panels for ACAT1

Sigma-Aldrich shRNA for ACAT1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000019

REFSEQ mRNAs for ACAT1 gene:

NM_000019.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000019

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000019
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000019
                                 untagged cDNA clones in CMV expression vector (see all 2): BC010942

Additional cDNA sequence:

AF086561.1 AK312574.1 BC010942.1 D90228.1 S70578.1

10 DOTS entries:

DT.95082281 DT.209848 DT.40305180 DT.75122408 DT.40105792 DT.75109020 DT.92033596 DT.120707187

DT.100014180 DT.65286160

24/84 AceView cDNA sequences (see all 84 ):

NM_000019 BM789408 F36678 CB158309 AA010069 CA776496 F28477 AL041431

AU142655 BP360666 AV708226 AI139512 CA776724 AU117943 BM722006 AU144630

AI202672 T85734 AW297552 BF528753 F27643 AU143159 F28457 BI870235

highest scoring ESTs for ACAT1:

AW945161 BQ304506 BQ319846 BQ353622 BQ353629 BQ375090 C01800 D90228 F27643 AA312281

Unigene Cluster for ACAT1:

Acetyl-Coenzyme A acetyltransferase 1

Hs.232375 [show with all ESTs]

Unigene Representative Sequence: NM_000019

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ACAT1 (see all 6 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13a	·	13b	^	14	^	15
SP1:							-		-								-				-				-								-				-
SP2:							-		-								-		-		-				-
SP3:							-		-								-
SP4:																																	-
SP5:							-		-

About this scheme

ECgene alternative splicing isoforms for ACAT1

3 Ensembl transcripts including schematic representations:

ENST00000265838 ENST00000375674 ENST00000299355

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ACAT1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ACAT1

¹ / ² / ³

5 probe-sets matching ACAT1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39678_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	D10511	0.20	1.00	0.72	1
205412_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000019	0.60	1.00	0.82	1
1554947_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205412_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1559239_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ACAT1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTAATTCAGA

SOURCE GeneReport for Unigene cluster: Hs.232375
Expression variation in blood from EXPOLDB for ACAT1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ACAT1 gene from 5/26 species (see all 26 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ACAT1¹	--	acetyl-Coenzyme A acetyltransferase 1	85.51(n) 88.16(a)	489421 XM_546539.2 XP_546539.2
chimpanzee (Pan troglodytes)	ACAT1¹	--	acetyl-Coenzyme A acetyltransferase 1	99.84(n) 100(a)	451528 XM_508738.2 XP_508738.2
cow (Bos taurus)	ACAT1¹	--	acetyl-Coenzyme A acetyltransferase 1	92.5(n) 91.71(a)	511082 NM_001046075.1 NP_001039540.1
rat (Rattus norvegicus)	Acat1¹	--	acetyl-coenzyme A acetyltransferase 1	83.18(n) 84.2(a)	25014 NM_017075.1 NP_058771.1
mouse (Mus musculus)	Acat1^{1, 5}	9 (30.00 cM)⁵	acetyl-Coenzyme A acetyltransferase 1^{1, 5}	85.69(n)¹ 84.2(a)¹	110446¹ NM_144784.3¹ NP_659033.1¹ AJ510150⁵ AK032097⁵ (see all 15)

About this table Species with no ortholog for ACAT1

ENSEMBL Gene Tree for ACAT1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ACAT1 gene

ACAA2² ACAT2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/183 NCBI SNPs in ACAT1 are shown (see all 183 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 43)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3741056^1,2	A,C,F,H	107497556(+)	`TGCTGG/CCGGCA`	1	P/A	mis¹		9		EA NA EU WA	2122
	rs2280332^1,2	C,F,H	107523926(+)	`CCTGGC/AGTTTG`	1	--	ng3¹		13		EA EU WA NA	2550
	rs3741055^1,2	A,C	107497535(+)	`AGCCCA/TCTGCG`	1	--	ut5¹ ese³		0	--	--	--	--
	rs3741054^1,2	C,H	107497522(+)	`GGAGCC/GGATAC`	1	--	ut5¹ ese³		3		EA WA	268
--	rs10890814^1,2	A,C	107496821(+)	`GGAGAC/TCTAGT`	1	--	ng5¹		0	--	--	--	--
--	rs7102368^1,2	A,C	107496097(+)	`aagatC/Tgcgcc`	1	--	ng5¹		0	--	--	--	--
--	rs1111610^1,2	C	107496833(-)	`tttttC/Tgtaga`	1	--	ng5¹ trp³		0	--	--	--	--
	rs35188041^1,2	F	107514870(+)	`ATGTCC/AAATGT`	1	S/S	syn¹		1		NA	72
	rs10749914^1,2	A,C,F,H	107517287(+)	`aagcaA/Ggagag`	1	--	int¹ trp³		8		EU EA WA	840
	rs7123836^1,2	A,C,F,H	107501113(+)	`TATATG/ATTCTG`	1	--	int¹		4		EU EA WA	416

About this table

HapMap Linkage Disequilibrium images for ACAT1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 607809 disorders: 203750

UniProtKB/Swiss-Prot: THIL_HUMAN, P24752

Defects in ACAT1 are a cause of 3-ketothiolase deficiency (3KTD) [MIM:203750]; also known

as alpha-methylacetoaceticaciduria. 3KTD is an inborn error of isoleucine catabolism characterized

by intermittent ketoacidotic attacks associated with unconsciousness. Some patients die during an

attack or are mentally retarded. Urinary excretion of 2-methyl-3-hydroxybutyric acid,

2-methylacetoacetic acid, triglylglycine, butanone is increased. It seems likely that the severity

of this disease correlates better with the environmental or acquired factors than with the ACAT1

genotype

4 Novoseek disease relationships for ACAT1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
beta-ketothiolase deficiency	98.57	27	14518824 (5), 15128923 (4), 7749408 (3), 7728148 (1) (see all 16)
ketoacidosis	53.23	1	16950638 (1)
ataxia telangiectasia	41.13	1	8786135 (1)
metabolic disorder	21.42	2	9001814 (1), 16935016 (1)

About this table

Genatlas disease: ACAT1

beta-ketothiolase deficiency,recurrent acidosis,ketosis with organic aciduria

Human Gene Mutation Database: ACAT1
Genetic Association Database: ACAT1
Human Genome Epidemiology Navigator: ACAT1 (9 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/64 PubMed articles for ACAT1 gene (see all 64 ):

Molecular cloning and sequence of the complementary DNA encoding human mitochondrial acetoacetyl-coenzyme A thiolase and study of the variant enzymes in cultured fibroblasts from patients with 3- ketothiolase deficiency. (PubMed id 1979337)^{1, 2, 3, 4} Fukao T....Hashimoto T. (1990)
Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function. (PubMed id 17371050)^{1, 3, 4} Haapalainen A.M....Wierenga R.K. (2007)
Characterization of N93S, I312T, and A333P missense mutations in two Japanese families with mitochondrial acetoacetyl-CoA thiolase deficiency. (PubMed id 9744475)^{1, 3, 4} Fukao T.... Kondo N. (1998)
Evidence for a structural mutation (347Ala to Thr) in a German family with 3-ketothiolase deficiency. (PubMed id 1715688)^{1, 3, 4} Fukao T.... Hashimoto T. (1991)
Identification of three mutant alleles of the gene for mitochondrial acetoacetyl-coenzyme A thiolase. A complete analysis of two generations of a family with 3-ketothiolase deficiency. (PubMed id 1346617)^{1, 3, 4} Fukao T....Hashimoto T. (1992)
Molecular, biochemical, and clinical characterization of mitochondrial acetoacetyl-coenzyme A thiolase deficiency in two further patients. (PubMed id 7728148)^{1, 3, 4} Wakazono A.... Hashimoto T. (1995)
Molecular basis of beta-ketothiolase deficiency: mutations and polymorphisms in the human mitochondrial acetoacetyl-coenzyme A thiolase gene. (PubMed id 7749408)^{1, 3, 4} Fukao T.... Hashimoto T. (1995)
Structure and expression of the human mitochondrial acetoacetyl-CoA thiolase-encoding gene. (PubMed id 1684944)^{1, 3, 4} Kano M.... Hashimoto T. (1991)
Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. (PubMed id 15242332)^{3, 4} Aboulaich N.... Vener A.V. (2004)
The influence of the acyl-CoA:cholesterol acyltransferase-1 gene (-77G-->A) polymorphisms on plasma lipid and apolipoprotein levels in normolipidemic and hyperlipidemic subjects. (PubMed id 15158756)^{3, 6} Ohta T....Fukuyama S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 38	HGNC: 93	AceView: ACAT1	Ensembl:ENSG00000075239	euGenes: HUgn38
ECgene: ACAT1	H-InvDB: ACAT1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=ACAT1

Licensable Technologies for ACAT1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ACAT1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ACAT1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ACAT1		Antibodies for ACAT1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ACAT1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ACAT1)
	Antibodies (ACAT1)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (ACAT1)
	Antibodies (ACAT1)

Search OriGene for ACAT1

Tocris compounds for ACAT1

	Drugs for ACAT1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for THIL

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ACAT1 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

ACAT1 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for ACAT1

Summaries
for ACAT1

Genomic Location
for ACAT1

Proteins
for ACAT1

Protein Domains/
Families
for ACAT1

Gene Function
for ACAT1

Pathways & Interactions
for ACAT1

Drugs & Compounds
for ACAT1

Transcripts
for ACAT1

Expression
for ACAT1

Orthologs
for ACAT1

Paralogs
for ACAT1

SNPs/Variants
for ACAT1

Disorders & Mutations
for ACAT1

Medical News
for ACAT1

Publications
for ACAT1

Search for ACAT1

Genome Databases showing ACAT1

Other Databases showing ACAT1

Specialized Databases showing ACAT1

Licensable Technologies
for ACAT1

Services
for ACAT1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ACAT1 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor ACAT1

Summariesfor ACAT1

Genomic Locationfor ACAT1

Proteinsfor ACAT1

Protein Domains/Familiesfor ACAT1

Gene Functionfor ACAT1

Pathways & Interactionsfor ACAT1

Drugs & Compoundsfor ACAT1

Transcriptsfor ACAT1

Expression for ACAT1

Orthologsfor ACAT1

Paralogsfor ACAT1

SNPs/Variantsfor ACAT1

Disorders & Mutationsfor ACAT1

Medical Newsfor ACAT1

Publicationsfor ACAT1

Search for ACAT1

Genome Databases showing ACAT1

Other Databases showing ACAT1

Specialized Databases showing ACAT1

Licensable Technologiesfor ACAT1

Servicesfor ACAT1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ACAT1

Summaries
for ACAT1

Genomic Location
for ACAT1

Proteins
for ACAT1

Protein Domains/
Families
for ACAT1

Gene Function
for ACAT1

Pathways & Interactions
for ACAT1

Drugs & Compounds
for ACAT1

Transcripts
for ACAT1

Expression
for ACAT1

Orthologs
for ACAT1

Paralogs
for ACAT1

SNPs/Variants
for ACAT1

Disorders & Mutations
for ACAT1

Medical News
for ACAT1

Publications
for ACAT1

Licensable Technologies
for ACAT1

Services
for ACAT1