Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACAP3 Gene

protein-coding   GIFtS: 52
GCID: GC01M001220

ArfGAP with coiled-coil, ankyrin repeat and PH domains 3

(Previous names: centaurin, beta 5 )
(Previous symbol: CENTB5)
 Explore 2 diseases affiliated with
ACAP3 via our new
 Human Malady Compendium 
Biological research products
for ACAP3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
ArfGAP With Coiled-Coil, Ankyrin Repeat And PH Domains 31 2     Centaurin-Beta-51
CENTB51 2 3     Cnt-B51
Centaurin, Beta 51 2     Centaurin-Beta-51
KIAA17161 3     Cnt-B51
Arf-GAP With Coiled-Coil, ANK Repeat And PH Domain-Containing Protein 32     

External Ids:    HGNC: 167541   Entrez Gene: 1169832   Ensembl: ENSG000001315847   UniProtKB: Q96P503   

Export aliases for ACAP3 gene to outside databases

Previous GC identifer: GC01M000498


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ACAP3_HUMAN, Q96P50
Function: GTPase-activating protein for the ADP ribosylation factor family (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004350.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACAP3 gene promoter:
         HEN1   HTF   NRSF form 1   ZID   STAT5A   NRSF form 2   GATA-2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ACAP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ACAP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACAP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36

ACAP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACAP3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001220:  view genomic region     (about GC identifiers)

Start:
1,227,756 bp from pter      End:
1,244,989 bp from pter
Size:
17,234 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ACAP3_HUMAN, Q96P50 (See protein sequence)
Recommended Name: Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3  
Size: 834 amino acids; 92495 Da
Sequence caution: Sequence=BAB21807.1; Type=Erroneous initiation;
Secondary accessions: B1AMF5 Q5TA42 Q5TA43 Q86UT3 Q9BSR9 Q9C0E7
Alternative splicing: 3 isoforms:  Q96P50-3   Q96P50-1   Q96P50-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ACAP3: NX_Q96P50

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96P50

  • ACAP3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_085152.2  
    ENSEMBL proteins: 
     ENSP00000346733   ENSP00000347075   ENSP00000321139  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for ACAP3 
    GenScript Custom Purified and Recombinant Proteins Services for ACAP3
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn


    ACAP3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ACAP3 
    GenScript Custom Superior Antibodies Services for ACAP3
    Novus Biologicals ACAP3 Antibodies
    Search for Antibodies for ACAP3 at Abcam  
    Browse Antibodies at Uscn
    ThermoFisher Antibodies for ACAP3

    Assay Products for ACAP3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ACAP3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ACAP3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR001849 Pleckstrin_homology
     IPR001164 ArfGAP
     IPR020683 Ankyrin_rpt-contain_dom
     IPR011993 PH_like_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q96P50

    ProtoNet protein and cluster: Q96P50

    2 Blocks protein families:
    IPB001164 HIV Rev interacting protein signature
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: ACAP3_HUMAN, Q96P50
    Similarity: Contains 3 ANK repeats
    Similarity: Contains 1 Arf-GAP domain
    Similarity: Contains 1 PH domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ACAP3_HUMAN, Q96P50
    Function: GTPase-activating protein for the ADP ribosylation factor family (Potential)

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: ACAP3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACAP3
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate ACAP3 (see all 11):
    hsa-miR-3910 hsa-miR-448 hsa-miR-3194-5p hsa-miR-1294 hsa-miR-3065-3p hsa-miR-1291 hsa-miR-153 hsa-miR-214
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACAP3 (see all 4)
    OriGene shRNA RFP: ACAP3
    OriGene siRNA: ACAP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACAP3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ACAP3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACAP3 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACAP3 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ACAP3 (NM_030649)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACAP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACAP3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ACAP3
    Search LifeMap BioReagents cell lines for ACAP3

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACAP3

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005543phospholipid binding IEA--
    GO:0008060ARF GTPase activator activity IEA--
    GO:0008093cytoskeletal adaptor activity ----
    GO:0008270zinc ion binding IEA--
    GO:0017124SH3 domain binding ----


    ACAP3 for ontologies           About GeneDecksing


    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Acap3):
     growth/size  limbs/digits/tail  skeleton 

    ACAP3 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Endocytosis
    Endocytosis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for ACAP3):
        Endocytosis


    ACAP3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACAP3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    4 Interacting proteins for ACAP3 (Q96P502, 3 ENSP000003467334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAB1Q157502, 3MINT-8259976 I2D: score=2 
    SLC35G2Q8TBE73, ENSP000003767944I2D: score=3 STRING: ENSP00000376794
    EIF6P565373I2D: score=3 
    ITGB3BPQ133523I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0032312regulation of ARF GTPase activity IEA--
    GO:0046847filopodium assembly ----


    ACAP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACAP3
    Search CenterWatch for drugs/clinical trials and news about ACAP3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ACAP3 gene: 
    NM_030649.2  

    Unigene Cluster for ACAP3:

    ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
    Hs.535257  [show with all ESTs]
    Unigene Representative Sequence: AB051503
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354700(uc001ady.2 uc001aeb.2) ENST00000492936(uc001aea.2)
    ENST00000467278 ENST00000470659 ENST00000379037 ENST00000476572 ENST00000493992
    ENST00000472541(uc001aec.1) ENST00000354980 ENST00000478065 ENST00000479108
    ENST00000438966 ENST00000353662

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: ACAP3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACAP3
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate ACAP3 (see all 11):
    hsa-miR-3910 hsa-miR-448 hsa-miR-3194-5p hsa-miR-1294 hsa-miR-3065-3p hsa-miR-1291 hsa-miR-153 hsa-miR-214
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACAP3 (see all 4)
    OriGene shRNA RFP: ACAP3
    OriGene siRNA: ACAP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACAP3
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACAP3 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACAP3 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ACAP3 (NM_030649)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACAP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACAP3 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACAP3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACAP3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACAP3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACAP3

    Additional cDNA sequence: 

    AB051503.1 AF411981.1 BC004874.2 BC021851.1 BC029929.1 BC047001.1 BC051194.1 

    15 DOTS entries:

    DT.111635  DT.100790603  DT.100009761  DT.100790609  DT.40233381  DT.95153087  DT.95258083  DT.102843164 
    DT.95264245  DT.95375592  DT.99952609  DT.121344516  DT.92429209  DT.99985536  DT.95163238 

    24/178 AceView cDNA sequences (see all 178):

    AK093954 BQ021879 BC051194 AI492175 AB051503 CR624645 BC004874 CF541288 
    BM762366 CA392299 BQ064850 BC021851 BM781937 CB053916 BU616405 H50507 
    BC047001 BM772330 AI650924 BU736552 AI524059 BM823954 BC029929 BM714690 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for ACAP3 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^
    SP1:                                                  -     -                 -     -     -     -                                         -     -               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                      -     -               
    SP4:                    -     -     -                 -     -                 -     -     -     -                                                               
    SP5:                                                                                                                                                            

    ExUns: 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c · 27d
    SP1:  -                                                                 -                                                   
    SP2:  -                                                                                                                     
    SP3:  -           -                                                                                                         
    SP4:                                                                                                                        
    SP5:                                                                          -                                             


    ECgene alternative splicing isoforms for ACAP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACAP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCACAAGCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ACAP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACAP3

    SOURCE GeneReport for Unigene cluster: Hs.535257
        SABiosciences Custom PCR Arrays for ACAP3
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACAP3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACAP3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACAP3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACAP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACAP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACAP3 gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ACAP31 ArfGAP with coiled-coil, ankyrin repeat and PH domains more 76.81(n)
    82.61(a)
      419420  XM_417581.3  XP_417581.2 
    lizard
    (Anolis carolinensis)
    Reptilia ACAP36
    --
    68(a)
    1 ↔ 1
    GL344013.1(27237-63659)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.176492 Transcribed sequence with moderate similarity to protein more 77.32(n)    AL969895.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.174612 Danio rerio cDNA clone IMAGE5776956, partial cds 74.23(n)    BC054928.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cenB1A6
    centaurin beta 1A
    31(a)
    1 → many
    3R(18944125-18949941)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AGD21 ADP-ribosylation factor GTPase-activating protein AGD2 41.31(n)
    33.63(a)
      842378  NM_104767.3  NP_176283.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g06325001 hypothetical protein 42.44(n)
    32.28(a)
      4330061  NM_001054038.1  NP_001047503.1 


    ENSEMBL Gene Tree for ACAP3 (if available)
    TreeFam Gene Tree for ACAP3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACAP3 gene
    AGAP52  AGAP62  ASAP12  ARAP32  ACAP22  GIT22  ARAP12  ASAP22  
    AGAP32  GIT12  ARAP22  AGAP22  AGAP42  AGAP12  AGAP82  ACAP12  
    AGAP72  AGAP102  AGAP92  ASAP32  
    7 SIMAP similar genes for ACAP3 using alignment to 4 protein entries:     ACAP3_HUMAN (see all proteins):
    ACAP2    ARFGAP1    ACAP1    ANK1    RAI14    ANKRD17
    ANKRD65

    ACAP3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/359 NCBI SNPs in ACAP3 are shown (see all 359    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1165761951,2
    --1227927(+) GGGCCG/AGGTCC 1 -- ut311Minor allele frequency- A:0.01NA 120
    rs1161759051,2
    F,--1227950(+) GCCCTC/TAGGGA 1 -- ut311Minor allele frequency- T:0.02WA 118
    rs1812531891,2
    --1227952(+) CCTCAA/GGGAGC 1 -- ut310--------
    rs1150748211,2
    F,--1228030(+) GGCCCT/CGCCTC 1 -- ut311Minor allele frequency- C:0.03WA 118
    rs66962491,2
    C--1228171(+) CCACAG/AAGAAA 1 -- ut31 ese3 trp32Minor allele frequency- A:0.00NA 4
    rs1846795241,2
    --1228276(+) TATGCA/GCAGGC 1 -- ut310--------
    rs756022421,2
    --1228312(+) GCCTCC/TGGAGG 1 -- ut310--------
    rs728962181,2
    C,--1228326(+) CCGGGT/ATGCGG 1 -- ut311Minor allele frequency- A:0.50WA 2
    rs795654981,2
    F,--1228797(+) TGGGCG/AAGCAG 1 -- ut311Minor allele frequency- A:0.08EA 120
    rs2014540951,2
    --1229095(+) TACGGA/GGAGGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for ACAP3 (1227756 - 1244989 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for ACAP3
         5 CNVs: 0001 3275 30362 31595 9864
         1 Indel: 43134

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACAP3
    DNA2.0 Custom Variant and Variant Library Synthesis for ACAP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ACAP3 for disorders           About GeneDecksing

    2 diseases for ACAP3:    About MalaCards
    malaria    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: ACAP3 (3 documents)

    Export disorders for ACAP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACAP3 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with ACAP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (2000)
    3. [CENTB5 gene expression in human and mouse] (PubMed id 19548526)1, 9 Shubina D.M....Patkin E.L. (2009)
    4. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    6. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    7. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)2 Beausoleil S.A.... Gygi S.P. (2006)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    9. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 116983 HGNC: 16754 AceView: CENTB5 Ensembl:ENSG00000131584 euGenes: HUgn116983
    ECgene: ACAP3 Kegg: 116983 H-InvDB: ACAP3

    (According to HUGE)
    About This Section
    HUGE: KIAA1716

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACAP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ACAP3 gene:
    Search GeneIP for patents involving ACAP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for ACAP3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACAP3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACAP3  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ACAP3   OriGene 3'-UTR Clone for ACAP3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACAP3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACAP3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ACAP3   OriGene Custom Protein Services for ACAP3  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ACAP3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACAP3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACAP3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACAP3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACAP3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACAP3
     GenScript Custom Purified and Recombinant Proteins Services for ACAP3 GenScript cDNA clones with any tag delivered in your preferred vector for ACAP3
     GenScript Custom Assay Services for ACAP3 GenScript Custom Superior Antibodies Services for ACAP3
     GenScript Custom overexpressing Cell Line Services for ACAP3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ACAP3 promoter
     Search Chromatin IP Primers for ACAP3
     RT2 qPCR Primer Assay in human, mouse, rat ACAP3
     Search GNC Networks for ACAP3
     SABiosciences Custom PCR Arrays for ACAP3
     Search Tocris compounds for ACAP3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ACAP3 antibodies
     Search for Antibodies for ACAP3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ACAP3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for ACAP3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACAP3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for ACAP3
     SwitchGear Promoter luciferase reporter plasmids for ACAP3
     ThermoFisher Antibodies for ACAP3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACAP3
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ACAP3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4