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Aliases for ACAP2 Gene

Aliases for ACAP2 Gene

  • ArfGAP With Coiled-Coil, Ankyrin Repeat And PH Domains 2 2 3
  • CENTB2 3 4 6
  • Centaurin, Beta 2 2 3
  • Centaurin-Beta-2 3 4
  • CNT-B2 3 4
  • Arf-GAP With Coiled-Coil, ANK Repeat And PH Domain-Containing Protein 2 3
  • Arf GAP With Coiled Coil, ANK Repeat And PH Domains 2 3
  • KIAA0041, 6
  • KIAA0041 4

External Ids for ACAP2 Gene

Previous HGNC Symbols for ACAP2 Gene

  • CENTB2

Previous GeneCards Identifiers for ACAP2 Gene

  • GC03M196477
  • GC03M194995
  • GC03M192371

Summaries for ACAP2 Gene

GeneCards Summary for ACAP2 Gene

ACAP2 (ArfGAP With Coiled-Coil, Ankyrin Repeat And PH Domains 2) is a Protein Coding gene. Among its related pathways are Endocytosis and Arf6 signaling events. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is ASAP3.

UniProtKB/Swiss-Prot for ACAP2 Gene

  • GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6).

Gene Wiki entry for ACAP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACAP2 Gene

Genomics for ACAP2 Gene

Regulatory Elements for ACAP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ACAP2 Gene

195,274,736 bp from pter
195,443,088 bp from pter
168,353 bases
Minus strand

Genomic View for ACAP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACAP2 Gene

Proteins for ACAP2 Gene

  • Protein details for ACAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K2V4
    • Q8N5Z8
    • Q9UQR3

    Protein attributes for ACAP2 Gene

    778 amino acids
    Molecular mass:
    88029 Da
    Quaternary structure:
    • Interacts with RAB35 (GTP-bound form); the interaction is direct and probably recruits ACAP2 to membranes. Interacts with MICALL1; the interaction is indirect through RAB35 (By similarity).
    • Sequence=BAA05064.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB41450.1; Type=Frameshift; Positions=98, 106, 111; Evidence={ECO:0000305};

neXtProt entry for ACAP2 Gene

Proteomics data for ACAP2 Gene at MOPED

Post-translational modifications for ACAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACAP2 Gene

No data available for DME Specific Peptides for ACAP2 Gene

Domains for ACAP2 Gene

Gene Families for ACAP2 Gene

  • ANKRD :Ankyrin repeat domain containing
  • ArfGAP :ADP-ribosylation factor GTPase activating proteins
  • PLEKH :Pleckstrin homology (PH) domain containing

Suggested Antigen Peptide Sequences for ACAP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q15057
  • Contains 1 Arf-GAP domain.
  • Contains 1 BAR domain.
  • Contains 1 PH domain.
  • Contains 3 ANK repeats.
genes like me logo Genes that share domains with ACAP2: view

Function for ACAP2 Gene

Molecular function for ACAP2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
UniProtKB/Swiss-Prot Function:
GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6).

Gene Ontology (GO) - Molecular Function for ACAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0017137 Rab GTPase binding IEA --
genes like me logo Genes that share ontologies with ACAP2: view

Animal Model Products

miRNA for ACAP2 Gene

miRTarBase miRNAs that target ACAP2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACAP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ACAP2 Gene

Localization for ACAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACAP2 Gene

Endosome membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for ACAP2 Gene COMPARTMENTS Subcellular localization image for ACAP2 gene
Compartment Confidence
cytosol 2
nucleus 2
endosome 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ACAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010008 endosome membrane ISS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ACAP2: view

Pathways for ACAP2 Gene

SuperPathways for ACAP2 Gene

genes like me logo Genes that share pathways with ACAP2: view

Pathways by source for ACAP2 Gene

1 BioSystems pathway for ACAP2 Gene
1 KEGG pathway for ACAP2 Gene

Interacting Proteins for ACAP2 Gene

Gene Ontology (GO) - Biological Process for ACAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036010 protein localization to endosome ISS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:1990090 cellular response to nerve growth factor stimulus ISS --
genes like me logo Genes that share ontologies with ACAP2: view

Compounds for ACAP2 Gene

(12) HMDB Compounds for ACAP2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Dipalmitoylphosphatidic acid
  • PA(16:0/18:1n7)
Not Available
  • PA(16:0/18:1n9)
Not Available
  • PA(34:2)
Not Available
  • 2-octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
Not Available
genes like me logo Genes that share compounds with ACAP2: view

Transcripts for ACAP2 Gene

Unigene Clusters for ACAP2 Gene

ArfGAP with coiled-coil, ankyrin repeat and PH domains 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACAP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACAP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP3: - - - - -
SP4: - - -
SP5: - - - -
SP7: - -
SP8: - - - -
SP12: -

ExUns: 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27
SP6: - - -

Relevant External Links for ACAP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACAP2 Gene

mRNA expression in normal human tissues for ACAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACAP2 Gene

This gene is overexpressed in Whole Blood (4.5).

Protein differential expression in normal tissues for ACAP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.0) and Lymph node (16.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACAP2 Gene

SOURCE GeneReport for Unigene cluster for ACAP2 Gene Hs.593373

mRNA Expression by UniProt/SwissProt for ACAP2 Gene

Tissue specificity: Widely expressed. Highest level in lung.
genes like me logo Genes that share expressions with ACAP2: view

Expression partners for ACAP2 Gene

In Situ Assay Products

Orthologs for ACAP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACAP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ACAP2 35
  • 92.46 (n)
  • 96.02 (a)
ACAP2 36
  • 93 (a)
(Mus musculus)
Mammalia Acap2 35
  • 89.31 (n)
  • 96.23 (a)
Acap2 16
Acap2 36
  • 96 (a)
(Pan troglodytes)
Mammalia ACAP2 35
  • 99.74 (n)
  • 100 (a)
ACAP2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Acap2 35
  • 89.26 (n)
  • 95.97 (a)
(Bos Taurus)
Mammalia ACAP2 36
  • 96 (a)
(Monodelphis domestica)
Mammalia ACAP2 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia ACAP2 36
  • 92 (a)
(Gallus gallus)
Aves ACAP2 35
  • 80.22 (n)
  • 88.55 (a)
ACAP2 36
  • 88 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 8 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia acap2 35
  • 75.66 (n)
  • 82.66 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68712 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2620 35
(Danio rerio)
Actinopterygii acap2 36
  • 70 (a)
ACAP2 (1 of 2) 36
  • 65 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000563 35
  • 49.44 (n)
  • 46.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta cenB1A 35
  • 48.08 (n)
  • 41.29 (a)
cenB1A 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea cnt-1 35
  • 46.32 (n)
  • 36.81 (a)
cnt-1 36
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AGE1 36
  • 21 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AGD2 35
  • 47.08 (n)
  • 34.34 (a)
(Oryza sativa)
Liliopsida Os02g0632500 35
  • 47.94 (n)
  • 34.02 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
Species with no ortholog for ACAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACAP2 Gene

Gene Tree for ACAP2 (if available)
Gene Tree for ACAP2 (if available)

Paralogs for ACAP2 Gene

Selected SIMAP similar genes for ACAP2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ACAP2: view

Variants for ACAP2 Gene

Sequence variations from dbSNP and Humsavar for ACAP2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs716898 -- 195,326,529(+) GCCCC(A/G)CAACA intron-variant
rs823297 -- 195,399,361(+) AGACA(A/G)GATCT intron-variant
rs823298 -- 195,400,343(+) ATATG(A/G)TTTCA intron-variant
rs823299 -- 195,401,438(+) GGTGG(C/G)TGGAT intron-variant
rs823300 -- 195,401,599(+) GAGGC(A/G)GAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACAP2 Gene

Variant ID Type Subtype PubMed ID
esv269140 CNV Insertion 20981092
nsv526569 CNV Gain 19592680
nsv878138 CNV Gain 21882294
dgv5364n71 CNV Loss 21882294
nsv878140 CNV Loss 21882294
dgv1549e1 CNV Complex 17122850
nsv878142 CNV Loss 21882294
dgv5365n71 CNV Loss 21882294
esv2726463 CNV Deletion 23290073
esv2669458 CNV Deletion 23128226
esv8403 CNV Gain 19470904
nsv829824 CNV Loss 17160897
esv2657233 CNV Deletion 23128226
nsv508977 CNV Insertion 20534489
esv2662107 CNV Deletion 23128226

Relevant External Links for ACAP2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACAP2 Gene

Disorders for ACAP2 Gene

(1) University of Copenhagen DISEASES for ACAP2 Gene

Relevant External Links for ACAP2

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ACAP2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for ACAP2 Gene

Publications for ACAP2 Gene

  1. ACAPs are arf6 GTPase-activating proteins that function in the cell periphery. (PMID: 11062263) Jackson T.R. … Randazzo P.A. (J. Cell Biol. 2000) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N. … Tabata S. (DNA Res. 1994) 3 4
  3. Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling. (PMID: 11050434) Jackson T.R. … Theibert A.B. (Trends Biochem. Sci. 2000) 2 3
  4. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. (PMID: 11001876) Dowler S.J. … Alessi D.R. (Biochem. J. 2000) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ACAP2 Gene

Sources for ACAP2 Gene

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