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Aliases for ACAP2 Gene

Aliases for ACAP2 Gene

  • ArfGAP With Coiled-Coil, Ankyrin Repeat And PH Domains 2 2 3 5
  • Centaurin-Beta-2 3 4
  • CNT-B2 3 4
  • CENTB2 3 4
  • Arf-GAP With Coiled-Coil, ANK Repeat And PH Domain-Containing Protein 2 3
  • Arf GAP With Coiled Coil, ANK Repeat And PH Domains 2 3
  • Centaurin, Beta 2 2
  • KIAA0041 4

External Ids for ACAP2 Gene

Previous HGNC Symbols for ACAP2 Gene

  • CENTB2

Previous GeneCards Identifiers for ACAP2 Gene

  • GC03M196477
  • GC03M194995
  • GC03M192371

Summaries for ACAP2 Gene

GeneCards Summary for ACAP2 Gene

ACAP2 (ArfGAP With Coiled-Coil, Ankyrin Repeat And PH Domains 2) is a Protein Coding gene. Among its related pathways are Arf6 signaling events and Endocytosis. GO annotations related to this gene include GTPase activator activity and Rab GTPase binding. An important paralog of this gene is ACAP3.

UniProtKB/Swiss-Prot for ACAP2 Gene

  • GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6).

Gene Wiki entry for ACAP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACAP2 Gene

Genomics for ACAP2 Gene

Regulatory Elements for ACAP2 Gene

Enhancers for ACAP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F196177 1.7 FANTOM5 Ensembl ENCODE 10.8 -737.8 -737803 7.1 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 YBX1 ZNF2 YY1 ENSG00000226345 ENSG00000213358 RPS29P3 UBXN7 TFRC RNU7-18P ACAP2 SLC51A LINC00885 TCTEX1D2
GH03F196078 1.2 ENCODE 14 -637.8 -637806 4.5 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 MUC4 ACAP2 TCTEX1D2 ENSG00000237418 NCBP2 UBXN7 MIR570 ENSG00000230732 MUC20 LINC00969
GH03F196285 1.1 ENCODE 14 -844.1 -844093 3.2 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 TM4SF19 PCYT1A ACAP2 ENSG00000260261 NCBP2 MIR570 SLC51A ENSG00000231443 NCBP2-AS1 ENSG00000228028
GH03F196163 1.5 FANTOM5 Ensembl ENCODE 9.9 -721.4 -721426 3.2 HDGF ZNF493 ARID4B SIN3A DMAP1 YBX1 ZNF2 SLC30A9 ZNF207 MXD4 SDHAP2 ENSG00000226345 ENSG00000213358 RPS29P3 LINC00969 ENSG00000230732 UBXN7 RNU6ATAC24P ACAP2 UBXN7-AS1
GH03F194491 1.3 FANTOM5 Ensembl ENCODE 10.8 +951.1 951085 1.4 HDAC1 LEF1 PKNOX1 RAD21 ZBTB40 GATA3 NCOR1 RFX1 MTA2 RNF2 ATP13A3 RNU6-1101P ACAP2 LINC00884
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ACAP2 on UCSC Golden Path with GeneCards custom track

Promoters for ACAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ACAP2 Gene

195,274,736 bp from pter
195,443,176 bp from pter
168,441 bases
Minus strand

Genomic View for ACAP2 Gene

Genes around ACAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACAP2 Gene

Proteins for ACAP2 Gene

  • Protein details for ACAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K2V4
    • Q8N5Z8
    • Q9UQR3

    Protein attributes for ACAP2 Gene

    778 amino acids
    Molecular mass:
    88029 Da
    Quaternary structure:
    • Interacts with RAB35 (GTP-bound form); the interaction is direct and probably recruits ACAP2 to membranes. Interacts with MICALL1; the interaction is indirect through RAB35 (By similarity).
    • Sequence=BAA05064.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB41450.1; Type=Frameshift; Positions=98, 106, 111; Evidence={ECO:0000305};

neXtProt entry for ACAP2 Gene

Post-translational modifications for ACAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ACAP2 Gene

Domains & Families for ACAP2 Gene

Suggested Antigen Peptide Sequences for ACAP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Arf-GAP domain.
  • Contains 3 ANK repeats.
  • Contains 1 Arf-GAP domain.
  • Contains 1 BAR domain.
  • Contains 1 PH domain.
  • Contains 3 ANK repeats.
genes like me logo Genes that share domains with ACAP2: view

Function for ACAP2 Gene

Molecular function for ACAP2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
UniProtKB/Swiss-Prot Function:
GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6).

Gene Ontology (GO) - Molecular Function for ACAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0017137 Rab GTPase binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ACAP2: view
genes like me logo Genes that share phenotypes with ACAP2: view

Animal Model Products

miRNA for ACAP2 Gene

miRTarBase miRNAs that target ACAP2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACAP2 Gene

Localization for ACAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACAP2 Gene

Endosome membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACAP2 gene
Compartment Confidence
endosome 5
plasma membrane 3
nucleus 3
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ACAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0010008 endosome membrane ISS --
GO:0016020 membrane IEA,IDA 19946888
genes like me logo Genes that share ontologies with ACAP2: view

Pathways & Interactions for ACAP2 Gene

SuperPathways for ACAP2 Gene

SuperPathway Contained pathways
1 Endocytosis
2 Arf6 signaling events
genes like me logo Genes that share pathways with ACAP2: view

Pathways by source for ACAP2 Gene

1 BioSystems pathway for ACAP2 Gene
1 KEGG pathway for ACAP2 Gene

Gene Ontology (GO) - Biological Process for ACAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036010 protein localization to endosome ISS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:1990090 cellular response to nerve growth factor stimulus ISS --
genes like me logo Genes that share ontologies with ACAP2: view

No data available for SIGNOR curated interactions for ACAP2 Gene

Drugs & Compounds for ACAP2 Gene

(12) Additional Compounds for ACAP2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphorate
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphoric acid
  • 1,2-Dihexadecanoyl-rac-phosphatidic acid
  • 1,2-Dipalmitoyl-3-sn-phosphatidate
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n7)
  • PA(16:0/18:1w7)
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n9)
  • PA(16:0/18:1w9)
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
  • PA(16:0/18:2n6)
  • PA(16:0/18:2w6)
  • 2-Octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
  • PA(O-16:0/18:0)
genes like me logo Genes that share compounds with ACAP2: view

Transcripts for ACAP2 Gene

Unigene Clusters for ACAP2 Gene

ArfGAP with coiled-coil, ankyrin repeat and PH domains 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACAP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP3: - - - - -
SP4: - - -
SP5: - - - -
SP7: - -
SP8: - - - -
SP12: -

ExUns: 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27
SP6: - - -

Relevant External Links for ACAP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ACAP2 Gene

mRNA differential expression in normal tissues according to GTEx for ACAP2 Gene

This gene is overexpressed in Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for ACAP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.0) and Lymph node (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACAP2 Gene

Protein tissue co-expression partners for ACAP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ACAP2 Gene:


SOURCE GeneReport for Unigene cluster for ACAP2 Gene:


mRNA Expression by UniProt/SwissProt for ACAP2 Gene:

Tissue specificity: Widely expressed. Highest level in lung.
genes like me logo Genes that share expression patterns with ACAP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ACAP2 Gene

Orthologs for ACAP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACAP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACAP2 34 35
  • 99.74 (n)
(Bos Taurus)
Mammalia ACAP2 35
  • 96 (a)
(Canis familiaris)
Mammalia ACAP2 34 35
  • 92.46 (n)
(Ornithorhynchus anatinus)
Mammalia ACAP2 35
  • 92 (a)
(Mus musculus)
Mammalia Acap2 34 16 35
  • 89.31 (n)
(Rattus norvegicus)
Mammalia Acap2 34
  • 89.26 (n)
(Monodelphis domestica)
Mammalia ACAP2 35
  • 80 (a)
(Gallus gallus)
Aves ACAP2 34 35
  • 80.22 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 8 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia acap2 34
  • 75.66 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68712 34
(Danio rerio)
Actinopterygii acap2 35
  • 70 (a)
ACAP2 (1 of 2) 35
  • 65 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2620 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000563 34
  • 49.44 (n)
fruit fly
(Drosophila melanogaster)
Insecta cenB1A 34 35
  • 48.08 (n)
(Caenorhabditis elegans)
Secernentea cnt-1 34 35
  • 46.32 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AGE1 35
  • 21 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AGD2 34
  • 47.08 (n)
(Oryza sativa)
Liliopsida Os02g0632500 34
  • 47.94 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
Species where no ortholog for ACAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACAP2 Gene

Gene Tree for ACAP2 (if available)
Gene Tree for ACAP2 (if available)

Paralogs for ACAP2 Gene

(3) SIMAP similar genes for ACAP2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ACAP2: view

Variants for ACAP2 Gene

Sequence variations from dbSNP and Humsavar for ACAP2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10212206 -- 195,421,865(+) AGAGA(C/T)TCAGA intron-variant
rs10439946 -- 195,359,372(+) aataa(C/T)gagta intron-variant
rs10439947 -- 195,359,504(+) gctct(A/G)tcacc intron-variant
rs10439948 -- 195,359,608(+) gacta(C/T)aggcg intron-variant
rs10439949 -- 195,359,762(+) gcgcc(C/T)ggcct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACAP2 Gene

Variant ID Type Subtype PubMed ID
esv2657233 CNV deletion 23128226
esv2662107 CNV deletion 23128226
esv2669458 CNV deletion 23128226
esv2726463 CNV deletion 23290073
esv2759213 CNV gain+loss 17122850
esv3304862 CNV mobile element insertion 20981092
esv3324582 CNV insertion 20981092
esv3599226 CNV gain 21293372
esv3599234 CNV loss 21293372
esv8403 CNV gain 19470904
nsv1006229 CNV gain 25217958
nsv1009796 CNV gain 25217958
nsv508977 CNV insertion 20534489
nsv526569 CNV gain 19592680
nsv829824 CNV loss 17160897
nsv963394 CNV duplication 23825009

Variation tolerance for ACAP2 Gene

Residual Variation Intolerance Score: 18.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACAP2 Gene

Disorders for ACAP2 Gene

Relevant External Links for ACAP2

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ACAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACAP2 Gene

Publications for ACAP2 Gene

  1. ACAPs are arf6 GTPase-activating proteins that function in the cell periphery. (PMID: 11062263) Jackson T.R. … Randazzo P.A. (J. Cell Biol. 2000) 2 3 4 22 64
  2. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling. (PMID: 11050434) Jackson T.R. … Theibert A.B. (Trends Biochem. Sci. 2000) 2 3 64
  5. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. (PMID: 11001876) Dowler S.J. … Alessi D.R. (Biochem. J. 2000) 3 22 64

Products for ACAP2 Gene

Sources for ACAP2 Gene

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