Aliases for ACAP2 Gene
Aliases for ACAP2 Gene
External Ids for ACAP2 Gene
- HGNC: 16469
- Entrez Gene: 23527
- Ensembl: ENSG00000114331
- OMIM: 607766
- UniProtKB: Q15057
Previous HGNC Symbols for ACAP2 Gene
- CENTB2
Previous GeneCards Identifiers for ACAP2 Gene
- GC03M196477
- GC03M194995
- GC03M192371
Summaries for ACAP2 Gene
GeneCards Summary for ACAP2 Gene
ACAP2 (ArfGAP With Coiled-Coil, Ankyrin Repeat And PH Domains 2) is a Protein Coding gene. Among its related pathways are Arf6 signaling events and Endocytosis. GO annotations related to this gene include GTPase activator activity and Rab GTPase binding. An important paralog of this gene is ACAP3.
UniProtKB/Swiss-Prot for ACAP2 Gene
-
GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACAP2 Gene
Genomics for ACAP2 Gene
Regulatory Elements for ACAP2 Gene
Enhancers for ACAP2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ACAP2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ACAP2 gene promoter:
Regulatory Element Products
Genomic Location for ACAP2 Gene
- Chromosome:
- 3
- Start:
- 195,274,736 bp from pter
- End:
- 195,443,176 bp from pter
- Size:
- 168,441 bases
- Orientation:
- Minus strand
Genomic View for ACAP2 Gene
Genes around ACAP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q29 by Ensembl
- 3q29 by Entrez Gene
- 3q29 by HGNC
ACAP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ACAP2 Gene
Proteins for ACAP2 Gene
-
Protein details for ACAP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15057-ACAP2_HUMAN
- Recommended name:
- Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
- Protein Accession:
- Q15057
- A8K2V4
- Q8N5Z8
- Q9UQR3
Protein attributes for ACAP2 Gene
- Size:
- 778 amino acids
- Molecular mass:
- 88029 Da
- Quaternary structure:
-
- Interacts with RAB35 (GTP-bound form); the interaction is direct and probably recruits ACAP2 to membranes. Interacts with MICALL1; the interaction is indirect through RAB35 (By similarity).
- SequenceCaution:
-
- Sequence=BAA05064.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB41450.1; Type=Frameshift; Positions=98, 106, 111; Evidence={ECO:0000305};
Protein Expression for ACAP2 Gene
Post-translational modifications for ACAP2 Gene
Other Protein References for ACAP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ACAP2
- Novus Biologicals Antibodies for ACAP2
- Invitrogen Antibodies for ACAP2
- antibodies-online Antibodies for ACAP2: See all 39
- GeneTex ACAP2 antibody for ACAP2
-
Santa Cruz Biotechnology (SCBT) Antibodies for ACAP2
Protein Products
-
OriGene Purified Proteins for ACAP2
- Search Origene for MassSpec and Protein Over-expression Lysates for ACAP2
- Origene Custom Protein Services for ACAP2
- antibodies-online Proteins for ACAP2: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ACAP2
Assay Products
- antibodies-online Kits for ACAP2: See all 8
No data available for DME Specific Peptides for ACAP2 Gene
Domains & Families for ACAP2 Gene
Gene Families for ACAP2 Gene
Protein Domains for ACAP2 Gene
Suggested Antigen Peptide Sequences for ACAP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ACAP2 Gene
Function for ACAP2 Gene
Molecular function for ACAP2 Gene
- UniProtKB/Swiss-Prot EnzymeRegulation:
- GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
- UniProtKB/Swiss-Prot Function:
- GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005096 | GTPase activator activity | IEA | -- |
| GO:0017137 | Rab GTPase binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ACAP2 Gene
- GenomeRNAi human phenotypes for ACAP2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ACAP2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ACAP2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ACAP2 gene
- Search ViGene Biosciences for ACAP2
CRISPR Products
-
OriGene CRISPR knockouts for ACAP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ACAP2
- GenScript: Design CRISPR guide RNA sequences for ACAP2
miRNA for ACAP2 Gene
- miRTarBase miRNAs that target ACAP2
-
- hsa-mir-378a-3p (MIRT043930)
- hsa-mir-106b-5p (MIRT441295)
- hsa-mir-20a-5p (MIRT441296)
- hsa-mir-1273e (MIRT443525)
- hsa-mir-4722-5p (MIRT443526)
- hsa-mir-1827 (MIRT443527)
- hsa-mir-219b-3p (MIRT443528)
- hsa-mir-4768-3p (MIRT443529)
- hsa-mir-940 (MIRT443530)
- hsa-mir-6893-5p (MIRT443531)
- hsa-mir-6808-5p (MIRT443532)
- hsa-mir-302f (MIRT443533)
- hsa-mir-4762-3p (MIRT611228)
- hsa-mir-505-3p (MIRT611229)
- hsa-mir-138-2-3p (MIRT611230)
- hsa-mir-1228-3p (MIRT611231)
- hsa-mir-362-3p (MIRT611232)
- hsa-mir-329-3p (MIRT611233)
- hsa-mir-8485 (MIRT611234)
- hsa-mir-409-5p (MIRT614293)
- hsa-mir-4539 (MIRT614294)
- hsa-mir-154-5p (MIRT614295)
- hsa-mir-6736-5p (MIRT624831)
- hsa-mir-4701-3p (MIRT624832)
- hsa-mir-1262 (MIRT624833)
- hsa-mir-7703 (MIRT624834)
- hsa-mir-661 (MIRT624835)
- hsa-mir-4696 (MIRT624836)
- hsa-mir-642b-3p (MIRT624837)
- hsa-mir-642a-3p (MIRT624838)
- hsa-mir-6776-5p (MIRT624839)
- hsa-mir-4793-3p (MIRT624840)
- hsa-mir-766-3p (MIRT624841)
- hsa-mir-6742-3p (MIRT624842)
- hsa-mir-6849-3p (MIRT624843)
- hsa-mir-508-5p (MIRT624844)
- hsa-mir-3120-3p (MIRT624845)
- hsa-mir-129-5p (MIRT624846)
- hsa-mir-6885-3p (MIRT624847)
- hsa-mir-4668-5p (MIRT624848)
- hsa-mir-103a-2-5p (MIRT624849)
- hsa-mir-1276 (MIRT624850)
- hsa-mir-6776-3p (MIRT635528)
- hsa-mir-6780a-5p (MIRT669655)
- hsa-mir-6779-5p (MIRT669656)
- hsa-mir-3689c (MIRT669657)
- hsa-mir-3689b-3p (MIRT669658)
- hsa-mir-3689a-3p (MIRT669659)
- hsa-mir-30b-3p (MIRT669660)
- hsa-mir-1273h-5p (MIRT669661)
- hsa-mir-4314 (MIRT669662)
- hsa-mir-7977 (MIRT669663)
- hsa-mir-6799-5p (MIRT669664)
- hsa-mir-6883-5p (MIRT669665)
- hsa-mir-6785-5p (MIRT669666)
- hsa-mir-4728-5p (MIRT669667)
- hsa-mir-149-3p (MIRT669668)
- hsa-mir-7106-5p (MIRT669669)
- hsa-mir-3975 (MIRT669670)
- hsa-mir-6506-5p (MIRT669671)
- hsa-mir-619-5p (MIRT669672)
- hsa-mir-3192-5p (MIRT669673)
- hsa-mir-4646-5p (MIRT669674)
- hsa-mir-204-3p (MIRT669675)
- hsa-mir-330-5p (MIRT669676)
- hsa-mir-326 (MIRT669677)
- hsa-mir-383-3p (MIRT669678)
- hsa-mir-514a-5p (MIRT669679)
- hsa-mir-4422 (MIRT669680)
- hsa-mir-6835-3p (MIRT669681)
- hsa-mir-519d-3p (MIRT728405)
- hsa-mir-93-5p (MIRT728406)
- hsa-mir-20b-5p (MIRT728407)
- hsa-mir-17-5p (MIRT728408)
miRNA Products
- Search ViGene Biosciences for ACAP2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ACAP2
- Browse OriGene Inhibitory RNA Products For ACAP2
-
ViGene Biosciences ready-to-package AAV shRNAs for ACAP2 gene
Clone Products
-
OriGene ORF clones in human for ACAP2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ACAP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ACAP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ACAP2
-
ViGene Biosciences adenoviral particle packaged cDNA for ACAP2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ACAP2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ACAP2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACAP2 Gene
Localization for ACAP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ACAP2 Gene
- Endosome membrane; Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| endosome | 5 |
| plasma membrane | 3 |
| nucleus | 3 |
| cytosol | 2 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005768 | endosome | IEA | -- |
| GO:0010008 | endosome membrane | ISS | -- |
| GO:0016020 | membrane | IEA,IDA | 19946888 |
Pathways & Interactions for ACAP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Endocytosis | ||
| 2 | Arf6 signaling events | ||
Pathways by source for ACAP2 Gene
1 BioSystems pathway for ACAP2 Gene
1 KEGG pathway for ACAP2 Gene
Interacting Proteins for ACAP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0036010 | protein localization to endosome | ISS | -- |
| GO:0043547 | positive regulation of GTPase activity | IEA | -- |
| GO:1990090 | cellular response to nerve growth factor stimulus | ISS | -- |
No data available for SIGNOR curated interactions for ACAP2 Gene
Drugs & Compounds for ACAP2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| PA(16:0/16:0) |
|
7091-44-3 |
|
|||
| PA(16:0/18:1(11Z)) |
|
|
||||
| PA(16:0/18:1(9Z)) |
|
|
||||
| PA(16:0/18:2(9Z,12Z)) |
|
|
||||
| PA(16:0e/18:0) |
|
|
Transcripts for ACAP2 Gene
mRNA/cDNA for ACAP2 Gene
- (11) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (187) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ACAP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ACAP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ACAP2
- GenScript: Design CRISPR guide RNA sequences for ACAP2
miRNA Products
- Search ViGene Biosciences for ACAP2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ACAP2
- Browse OriGene Inhibitory RNA Products For ACAP2
-
ViGene Biosciences ready-to-package AAV shRNAs for ACAP2 gene
Clone Products
-
OriGene ORF clones in human for ACAP2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ACAP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ACAP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - |
| ExUns: | 20 | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26 | ^ | 27 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||
| SP2: | |||||||||||||||||||
| SP3: | |||||||||||||||||||
| SP4: | |||||||||||||||||||
| SP5: | |||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||
| SP7: | |||||||||||||||||||
| SP8: | |||||||||||||||||||
| SP9: | |||||||||||||||||||
| SP10: | |||||||||||||||||||
| SP11: | |||||||||||||||||||
| SP12: |
Expression for ACAP2 Gene
mRNA differential expression in normal tissues according to GTEx for ACAP2 Gene
This gene is overexpressed in Whole Blood (x4.5).
This gene is overexpressed in Peripheral blood mononuclear cells (25.0) and Lymph node (16.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ACAP2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ACAP2 Gene:
ACAP2SOURCE GeneReport for Unigene cluster for ACAP2 Gene:
Hs.593373mRNA Expression by UniProt/SwissProt for ACAP2 Gene:
Q15057-ACAP2_HUMAN
Tissue specificity:
Widely expressed. Highest level in lung.
Evidence on tissue expression from TISSUES for ACAP2 Gene
- Nervous system(4.6)
- Blood(4.3)
- Bone marrow(4.2)
- Liver(4.2)
- Lung(2.1)
Primer Products
-
OriGene qPCR primer pairs for ACAP2
-
OriGene qPCR primer pairs and template standards for ACAP2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACAP2 Gene
Orthologs for ACAP2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ACAP2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ACAP2 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ACAP2 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ACAP2 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Acap2 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Acap2 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ACAP2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ACAP2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | acap2 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68712 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | acap2 35 |
|
OneToMany | |
| ACAP2 (1 of 2) 35 |
|
OneToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2620 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000563 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | cenB1A 35 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | cnt-1 34 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | AGE1 35 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AGD2 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0632500 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for ACAP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ACAP2 Gene
Paralogs for ACAP2 Gene
(3) SIMAP similar genes for ACAP2 Gene using alignment to 6 proteins:
Variants for ACAP2 Gene
| SNP ID | Clin | Chr 03 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000009344 | -- | 195,313,803(+) | TTTCC(C/T)TCATC | intron-variant | |
| rs1000029154 | -- | 195,428,561(+) | TACAG(G/T)TTTGT | intron-variant | |
| rs1000043543 | -- | 195,429,877(+) | TTTTG(C/T)CTATG | intron-variant | |
| rs1000080714 | -- | 195,419,301(+) | GCCTA(C/T)ATGCA | intron-variant | |
| rs1000083922 | -- | 195,393,052(+) | TATTT(A/C)CAGAA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2657233 | CNV | deletion | 23128226 |
| esv2662107 | CNV | deletion | 23128226 |
| esv2669458 | CNV | deletion | 23128226 |
| esv2726463 | CNV | deletion | 23290073 |
| esv2759213 | CNV | gain+loss | 17122850 |
| esv3304862 | CNV | mobile element insertion | 20981092 |
| esv3324582 | CNV | insertion | 20981092 |
| esv3599226 | CNV | gain | 21293372 |
| esv3599234 | CNV | loss | 21293372 |
| esv8403 | CNV | gain | 19470904 |
| nsv1006229 | CNV | gain | 25217958 |
| nsv1009796 | CNV | gain | 25217958 |
| nsv508977 | CNV | insertion | 20534489 |
| nsv526569 | CNV | gain | 19592680 |
| nsv829824 | CNV | loss | 17160897 |
| nsv963394 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
18.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.19;
23.99% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ACAP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ACAP2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACAP2 Gene
Disorders for ACAP2 Gene
Relevant External Links for ACAP2
No disorders were found for ACAP2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACAP2 Gene
Publications for ACAP2 Gene
- ACAPs are arf6 GTPase-activating proteins that function in the cell periphery. (PMID: 11062263) Jackson T.R. … Randazzo P.A. (J. Cell Biol. 2000) 2 3 4 22 64
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. (PMID: 11001876) Dowler S.J. … Alessi D.R. (Biochem. J. 2000) 3 22 64
- Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling. (PMID: 11050434) Jackson T.R. … Theibert A.B. (Trends Biochem. Sci. 2000) 2 3 64
Products for ACAP2 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for ACAP2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ACAP2
- Search Origene for MassSpec and Protein Over-expression Lysates for ACAP2
- Origene Custom Protein Services for ACAP2
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ACAP2
- Browse OriGene Inhibitory RNA Products For ACAP2
- OriGene qPCR primer pairs and template standards for ACAP2
- OriGene qPCR primer pairs for ACAP2
- OriGene CRISPR knockouts for ACAP2
- OriGene ORF clones in human for ACAP2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ACAP2
- GenScript: Next-day shipping cDNA ORF clone for ACAP2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ACAP2
- GenScript Custom Assay Services for ACAP2
- GenScript Custom overexpressing Cell Line Services for ACAP2
- GenScript: Design CRISPR guide RNA sequences for ACAP2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ACAP2
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for ACAP2
- Novus Biologicals proteins and lysates for ACAP2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for ACAP2: See all 39
- antibodies-online Kits for ACAP2: See all 8
- antibodies-online Proteins for ACAP2: See all 5
- Search antibodies-online for peptides
- GeneTex ACAP2 antibody for ACAP2
- Search GeneTex for Proteins for ACAP2
- ViGene Biosciences adenoviral particle packaged cDNA for ACAP2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for ACAP2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ACAP2 gene
- Search ViGene Biosciences for ACAP2
- Santa Cruz Biotechnology (SCBT) Antibodies for ACAP2
- Search Santa Cruz Biotechnology (SCBT) for ACAP2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ACAP2
- Horizon Cell Lines for ACAP2
- Cyagen custom Knockout/knockin (KOKI) mouse models for ACAP2
- VectorBuilder custom plasmid, inducible vectors for ACAP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ACAP2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ACAP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer