Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ACAP1 Gene

Aliases for ACAP1 Gene

  • ArfGAP With Coiled-Coil, Ankyrin Repeat And PH Domains 1 2 3
  • CENTB1 3 4 6
  • Centaurin, Beta 1 2 3
  • Centaurin-Beta-1 3 4
  • Cnt-B1 3 4
  • Arf-GAP With Coiled-Coil, ANK Repeat And PH Domain-Containing Protein 1 3
  • Arf GAP With Coiled Coil, ANK Repeat And PH Domains 1 3
  • KIAA0050, 6
  • KIAA0050 4

External Ids for ACAP1 Gene

Previous Symbols for ACAP1 Gene

  • CENTB1

Summaries for ACAP1 Gene

GeneCards Summary for ACAP1 Gene

ACAP1 (ArfGAP With Coiled-Coil, Ankyrin Repeat And PH Domains 1) is a Protein Coding gene. Among its related pathways are Endocytosis and Arf6 signaling events. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is ASAP3.

UniProtKB/Swiss-Prot for ACAP1 Gene

  • GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.

Gene Wiki entry for ACAP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACAP1 Gene

Genomics for ACAP1 Gene

Genomic Location for ACAP1 Gene

Start:
7,336,529 bp from pter
End:
7,351,478 bp from pter
Size:
14,950 bases
Orientation:
Plus strand

Genomic View for ACAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACAP1 Gene

Regulatory Elements for ACAP1 Gene

Proteins for ACAP1 Gene

  • Protein details for ACAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15027-ACAP1_HUMAN
    Recommended name:
    Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
    Protein Accession:
    Q15027
    Secondary Accessions:
    • Q53XN9

    Protein attributes for ACAP1 Gene

    Size:
    740 amino acids
    Molecular mass:
    81536 Da
    Quaternary structure:
    • Banana-shaped homodimer laterally assembling into tetramers, the tetramers further pack helically onto the membrane. Interacts with GTP-bound ARF6. Interacts with third cytoplasmic loop of SLC2A4/GLUT4. Interacts with CLTC. Interacts with GULP1. Forms a complex with GDP-bound ARF6 and GULP1. Interacts with ITGB1; required for ITGB1 recycling.
    Miscellaneous:
    • Cells overexpressing ACAP1 show an accumulation of ITGB1 in recycling endosomes and inhibition of stimulation-dependent cell migration. Cells with reduced levels of ACAP1 or AKT1 and AKT2 show inhibition of stimulation-dependent cell migration. Cells overexpressing ACAP1 and PIP5K1C show formation of tubular structures derived from endosomal membranes
    SequenceCaution:
    • Sequence=BAA06418.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ACAP1 Gene

neXtProt entry for ACAP1 Gene

Proteomics data for ACAP1 Gene at MOPED

Post-translational modifications for ACAP1 Gene

  • Phosphorylation at Ser-554 by PKB is required for interaction with ITGB1, export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys40, Lys90, Lys114, Lys183, Lys185, Lys218, Lys248, Lys274, Lys522, and Lys558

Other Protein References for ACAP1 Gene

No data available for DME Specific Peptides for ACAP1 Gene

Domains for ACAP1 Gene

Gene Families for ACAP1 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
  • ArfGAP :ADP-ribosylation factor GTPase activating proteins
  • ANKRD :Ankyrin repeat domain containing

UniProtKB/Swiss-Prot:

ACAP1_HUMAN
Domain:
  • PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate ACAP1-binding to PIP2 or PIP3 containing membranes. Only one PH domain of one ACAP1 dimer inserts into the membrane, while the other PH domain acts primaryly to interact with adjacent ACAP1 dimers.:
    • Q15027
  • The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.:
    • Q15027
  • Contains 1 Arf-GAP domain.:
    • Q15027
  • Contains 1 BAR domain.:
    • Q15027
  • Contains 1 PH domain.:
    • Q15027
Similarity:
  • Contains 3 ANK repeats.:
    • Q15027
genes like me logo Genes that share domains with ACAP1: view

Function for ACAP1 Gene

Molecular function for ACAP1 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
UniProtKB/Swiss-Prot Function: GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.

Gene Ontology (GO) - Molecular Function for ACAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ACAP1: view

Phenotypes for ACAP1 Gene

GenomeRNAi human phenotypes for ACAP1:
genes like me logo Genes that share phenotypes with ACAP1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ACAP1 Gene

Localization for ACAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACAP1 Gene

Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACAP1 Gene COMPARTMENTS Subcellular localization image for ACAP1 gene
Compartment Confidence
cytosol 3
nucleus 3
endosome 2

Gene Ontology (GO) - Cellular Components for ACAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome --
GO:0016020 membrane IDA 19946888
GO:0055038 recycling endosome membrane IEA --
genes like me logo Genes that share ontologies with ACAP1: view

Pathways for ACAP1 Gene

genes like me logo Genes that share pathways with ACAP1: view

Pathways by source for ACAP1 Gene

3 BioSystems pathways for ACAP1 Gene
1 KEGG pathway for ACAP1 Gene

Gene Ontology (GO) - Biological Process for ACAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ACAP1: view

Compounds for ACAP1 Gene

(392) HMDB Compounds for ACAP1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
PA(16:0/16:0)
  • Dipalmitoylphosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • PA(16:0/18:1n7)
Not Available
PA(16:0/18:1(9Z))
  • PA(16:0/18:1n9)
Not Available
PA(16:0/18:2(9Z,12Z))
  • PA(34:2)
Not Available
genes like me logo Genes that share compounds with ACAP1: view

Transcripts for ACAP1 Gene

Unigene Clusters for ACAP1 Gene

ArfGAP with coiled-coil, ankyrin repeat and PH domains 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACAP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a ·
SP1: - - - - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - - - -
SP6: -
SP7:
SP8:

ExUns: 22b ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for ACAP1 Gene

GeneLoc Exon Structure for
ACAP1
ECgene alternative splicing isoforms for
ACAP1

Expression for ACAP1 Gene

mRNA expression in normal human tissues for ACAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACAP1 Gene

This gene is overexpressed in Whole Blood (26.9) and Spleen (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACAP1 Gene

SOURCE GeneReport for Unigene cluster for ACAP1 Gene Hs.337242

mRNA Expression by UniProt/SwissProt for ACAP1 Gene

Q15027-ACAP1_HUMAN
Tissue specificity: Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas.
genes like me logo Genes that share expressions with ACAP1: view

Orthologs for ACAP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACAP1 36
  • 98.65 (n)
  • 98.26 (a)
ACAP1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACAP1 36
  • 91.35 (n)
  • 94.32 (a)
ACAP1 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACAP1 36
  • 85.95 (n)
  • 87.84 (a)
ACAP1 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acap1 36
  • 87.84 (n)
  • 93.11 (a)
Acap1 16
Acap1 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACAP1 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acap1 36
  • 87.66 (n)
  • 92.3 (a)
zebrafish
(Danio rerio)
Actinopterygii acap1 36
  • 61.08 (n)
  • 59.62 (a)
acap1 37
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta cenB1A 37
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cnt-1 37
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AGE1 37
  • 20 (a)
OneToMany
AGE1 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 32 (a)
OneToMany
Species with no ortholog for ACAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ACAP1 Gene

ENSEMBL:
Gene Tree for ACAP1 (if available)
TreeFam:
Gene Tree for ACAP1 (if available)

Paralogs for ACAP1 Gene

Selected SIMAP similar genes for ACAP1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ACAP1: view

Variants for ACAP1 Gene

Sequence variations from dbSNP and Humsavar for ACAP1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2292066 -- 7,348,286(+) ACTGC(A/C/G)TGCTT intron-variant
rs2292067 -- 7,348,829(+) CATAC(G/T)CATAC intron-variant
rs3809824 -- 7,334,809(+) TGAGA(A/G)CCTGG upstream-variant-2KB
rs3809825 -- 7,334,867(+) GGTAC(A/C)CGAGC upstream-variant-2KB
rs3809826 -- 7,335,199(+) TCAGA(A/G)GCGGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ACAP1 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
dgv3053n71 CNV Loss 21882294
nsv907641 CNV Loss 21882294
nsv509650 CNV Insertion 20534489
nsv907642 CNV Loss 21882294
esv2671173 CNV Deletion 23128226
nsv907643 CNV Loss 21882294

Relevant External Links for ACAP1 Gene

HapMap Linkage Disequilibrium report
ACAP1

Disorders for ACAP1 Gene

Relevant External Links for ACAP1

Genetic Association Database (GAD)
ACAP1
Human Genome Epidemiology (HuGE) Navigator
ACAP1
genes like me logo Genes that share disorders with ACAP1: view

No data available for UniProtKB/Swiss-Prot for ACAP1 Gene

Publications for ACAP1 Gene

  1. ACAPs are arf6 GTPase-activating proteins that function in the cell periphery. (PMID: 11062263) Jackson T.R. … Randazzo P.A. (J. Cell Biol. 2000) 2 3 4 23
  2. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PMID: 16777052) Zhan X. … Desiderio D.M. (Anal. Biochem. 2006) 3 4 23
  3. Cooperation of phosphoinositides and BAR domain proteins in endosomal tubulation. (PMID: 17010122) Shinozaki-Narikawa N. … Shibasaki Y. (Traffic 2006) 3 4 23
  4. An ACAP1-containing clathrin coat complex for endocytic recycling. (PMID: 17664335) Li J. … Hsu V.W. (J. Cell Biol. 2007) 3 4 23
  5. Centaurin beta1 down-regulates nucleotide-binding oligomerization domains 1- and 2-dependent NF-kappaB activation. (PMID: 17005562) Yamamoto-Furusho J.K. … Podolsky D.K. (J. Biol. Chem. 2006) 3 23

Products for ACAP1 Gene

  • Addgene plasmids for ACAP1

Sources for ACAP1 Gene

Back to Top

Content