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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACAP1 Gene

protein-coding   GIFtS: 56
GCID: GC17P007239

ArfGAP with coiled-coil, ankyrin repeat and PH domains 1

(Previous names: centaurin, beta 1 )
(Previous symbol: CENTB1)
 Explore 4 diseases affiliated with
ACAP1 via our new
 Human Malady Compendium 
Biological research products
for ACAP1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
ArfGAP With Coiled-Coil, Ankyrin Repeat And PH Domains 11 2     Arf-GAP With Coiled-Coil, ANK Repeat And PH Domain-Containing Protein 12
CENTB11 2 3 5     Centaurin-Beta-11
KIAA00501 3 5     Cnt-B11
Centaurin, Beta 11 2     Centaurin-Beta-11
Arf GAP With Coiled Coil, ANK Repeat And PH Domains 12     Cnt-B11

External Ids:    HGNC: 164671   Entrez Gene: 97442   Ensembl: ENSG000000728187   OMIM: 6077635   UniProtKB: Q150273   

Export aliases for ACAP1 gene to outside databases

Previous GC identifers: GC17P007181 GC17P007133


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ACAP1_HUMAN, Q15027
Function: GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export
of proteins from recycling endosomes to trans-Golgi network and cell surface

Gene Wiki entry for ACAP1 (CENTB1)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACAP1 gene promoter:
         COUP-TF1   COUP-TF   AP-1   ATF-2   COUP   c-Jun   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACAP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ACAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

ACAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACAP1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007239:  view genomic region     (about GC identifiers)

Start:
7,239,848 bp from pter      End:
7,254,797 bp from pter
Size:
14,950 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ACAP1_HUMAN, Q15027 (See protein sequence)
Recommended Name: Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1  
Size: 740 amino acids; 81536 Da
Subunit: Interacts with GTP-bound ARF6. Interacts with third cytoplasmic loop of SLC2A4/GLUT4. Interacts with CLTC.
Interacts with GULP1. Forms a complex with GDP-bound ARF6 and GULP1
Miscellaneous: Cells overexpressing ACAP1 show an accumulation of ITGB1 in recycling endosomes and inhibition of
stimulation-dependent cell migration. Cells with reduced levels of ACAP1 or AKT1 and AKT2 show inhibition of
stimulation-dependent cell migration. Cells overexpressing ACAP1 and PIP5K1C show formation of tubular structures
derived from endosomal membranes
Sequence caution: Sequence=BAA06418.2; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for ACAP1:
3JUE (3D)        3T9K (3D)        4F1P (3D)    
Secondary accessions: Q53XN9

Explore the universe of human proteins at neXtProt for ACAP1: NX_Q15027

Post-translational modifications:

  • Phosphorylation at Ser-554 by PKB is required for interaction with ITGB1, export of ITGB1 from recycling endosomes to
  • the cell surface and ITGB1-dependent cell migration1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15027

  • ACAP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055531.1  
    ENSEMBL proteins: 
     ENSP00000158762   ENSP00000458173   ENSP00000459422   ENSP00000461314   ENSP00000460735  
     ENSP00000460803   ENSP00000460054  

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    Browse Proteins at Uscn

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----


    ACAP1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ACAP1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR000909 PLipase_C_PInositol-sp_X_dom
     IPR001849 Pleckstrin_homology
     IPR001164 ArfGAP
     IPR020683 Ankyrin_rpt-contain_dom
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q15027

    ProtoNet protein and cluster: Q15027

    3 Blocks protein families:
    IPB001164 HIV Rev interacting protein signature
    IPB001849 Pleckstrin-like
    IPB002110 Ankyrin repeat signature


    UniProtKB/Swiss-Prot: ACAP1_HUMAN, Q15027
    Domain: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate,
    phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate
    ACAP1-binding to PIP2 or PIP3 containing membranes
    Similarity: Contains 3 ANK repeats
    Similarity: Contains 1 Arf-GAP domain
    Similarity: Contains 1 BAR domain
    Similarity: Contains 1 PH domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ACAP1_HUMAN, Q15027
    Function: GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export
    of proteins from recycling endosomes to trans-Golgi network and cell surface
    Enzyme regulation: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid

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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004629phospholipase C activity ----
    GO:0005543phospholipid binding IEA--
    GO:0008060ARF GTPase activator activity IEA--
    GO:0008270zinc ion binding IEA--
    GO:0019904protein domain specific binding IEA--


    ACAP1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ACAP1:
     Decreased focal adhesion (FA)  


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Arf6 signaling events
    Arf6 signaling events1.00
    2Arf6 trafficking events
    Arf6 trafficking events1.00
    3Endocytosis
    Endocytosis1.00
    4Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    NOD pathway0.23

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 BioSystems Pathways for ACAP1 
        NOD pathway
    Arf6 signaling events
    Arf6 trafficking events


    1         Kegg Pathway  (Kegg details for ACAP1):
        Endocytosis


    ACAP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ACAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/20 Interacting proteins for ACAP1 (Q150272, 3 ENSP000001587624) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IFFO1Q0D2I53, ENSP000003493644I2D: score=4 STRING: ENSP00000349364
    VAMP3Q158363, ENSP000000546664I2D: score=3 STRING: ENSP00000054666
    GULP1Q9UBP93, ENSP000003520474I2D: score=2 STRING: ENSP00000352047
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    SLC2A4P146723, ENSP000003209354I2D: score=1 STRING: ENSP00000320935
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process ----
    GO:0015031protein transport IEA--
    GO:0032312regulation of ARF GTPase activity IEA--
    GO:0035556intracellular signal transduction ----


    ACAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ACAP1

    10/392 HMDB Compounds for ACAP1 (see all 392)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    PA(16:0/16:0)Dipalmitoylphosphatidic acid (see all 25)7091-44-3--
    PA(16:0/18:1(11Z))PA(16:0/18:1n7) (see all 10)----
    PA(16:0/18:1(9Z))PA(16:0/18:1n9) (see all 10)----
    PA(16:0/18:2(9Z,12Z))PA(34:2) (see all 10)----
    PA(16:0e/18:0)2-octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate ;PA(o-16:0/18:0) ----
    PA(18:0/18:2(9Z,12Z))PA(36:2) (see all 10)----
    PA(18:1(11Z)/18:1(11Z))PA(36:2) (see all 10)----
    PA(18:1(11Z)/18:1(9Z))PA(36:2) (see all 10)----
    PA(18:1(9Z)/18:1(11Z))PA(36:2) (see all 10)----
    Search CenterWatch for drugs/clinical trials and news about ACAP1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ACAP1 gene: 
    NM_014716.3  

    Unigene Cluster for ACAP1:

    ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
    Hs.337242  [show with all ESTs]
    Unigene Representative Sequence: AK126509
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000158762(uc002ggd.2) ENST00000570457 ENST00000575425 ENST00000576628
    ENST00000573893 ENST00000571220 ENST00000570439 ENST00000576594 ENST00000571471
    ENST00000570504 ENST00000574499 ENST00000575415

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    Additional cDNA sequence: 

    AK126509.1 BC018543.1 BT009788.1 D30758.1 

    9 DOTS entries:

    DT.446222  DT.40227542  DT.100637293  DT.120961877  DT.100645735  DT.100864205  DT.435526  DT.97817607 
    DT.95343392 

    24/190 AceView cDNA sequences (see all 190):

    BM773027 BQ955458 BM683831 CK903560 AA713946 BC018543 BG678759 BI029099 
    BQ011639 BI962890 BC063604 BX480095 D30758 CD558797 BQ063688 BI518826 
    BM783524 CR599042 AI625175 NM_014716 BG490596 NM_001002914 CF995075 AY646650 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ACAP1 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a ·
    SP1:        -                 -                 -     -                                                                                               -     -   
    SP2:                          -                 -     -                                                                                                         
    SP3:                                            -     -                                                                                                         
    SP4:        -                 -                                                                                                                                 
    SP5:        -     -           -                 -     -                                                                                                         

    ExUns: 22b ^ 23
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for ACAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCTCCACAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ACAP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACAP1

    SOURCE GeneReport for Unigene cluster: Hs.337242

    UniProtKB/Swiss-Prot: ACAP1_HUMAN, Q15027
    Tissue specificity: Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACAP1 gene from 4/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii acap11 ArfGAP with coiled-coil, ankyrin repeat and PH domains more 60.85(n)
    60.16(a)
      561771  NM_001080579.1  NP_001074048.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cenB1A6
    centaurin beta 1A
    29(a)
    1 → many
    3R(18944125-18949941)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AGD46
    AGD26
    (see all 4)
    ADP-ribosylation factor GTPase-activating protein ...
    ADP-ribosylation factor GTPase-activating protein ...
    (see all 4)
    20(a)
    20(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    1(3616610-3623758)
    1(22400927-22407777)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 3)
    ARF GTPase-activating domain-containing protein, p...
    ARF GTPase-activating domain-containing protein, p...
    (see all 3)
    21(a)
    20(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2(25323314-25336072)
    9(19823228-19830851)


    ENSEMBL Gene Tree for ACAP1 (if available)
    TreeFam Gene Tree for ACAP1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACAP1 gene
    AGAP52  AGAP62  ASAP12  ARAP32  ACAP22  GIT22  ACAP32  ARAP12  
    ASAP22  AGAP32  GIT12  ARAP22  AGAP22  AGAP42  AGAP12  AGAP82  
    AGAP72  AGAP102  AGAP92  ASAP32  
    2 SIMAP similar genes for ACAP1 using alignment to 5 protein entries:     ACAP1_HUMAN (see all proteins):
    ACAP2    ACAP3

    ACAP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/294 NCBI SNPs in ACAP1 are shown (see all 294    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1808009951,2
    --7238092(+) GCTTGC/TAGAGG 1 -- us2k10--------
    rs38098241,2
    C,F,A,H,--7238128(+) TGAGAG/ACCTGG 1 -- us2k122Minor allele frequency- A:0.27NS EA NA WA CSA 1521
    rs38098251,2
    C,F,A,H,--7238186(+) GGTACA/CCGAGC 1 -- us2k114Minor allele frequency- C:0.29NA WA CSA EA 379
    rs1862403461,2
    --7238292(+) TTTAGG/TGATCA 1 -- us2k10--------
    rs38265111,2
    C,F,H,--7238325(+) ATGGCG/AACAAT 1 -- us2k116Minor allele frequency- A:0.27NA WA CSA EA 514
    rs1438385391,2
    --7238350(+) CTGTTA/GAGGGC 1 -- us2k10--------
    rs38098261,2
    C,F,H,--7238518(+) TCAGAA/GGCGGT 1 -- us2k127Minor allele frequency- G:0.25EA NS NA WA CSA 3376
    rs1472352251,2
    --7238883(+) TCAAAC/GTCTTC 1 -- us2k10--------
    rs1919594361,2
    --7239001(+) ACCCTA/GTGAAT 1 -- us2k10--------
    rs1389473391,2
    --7239024(+) CAGAAC/GAGCAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ACAP1 (7239848 - 7254797 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ACAP1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for ACAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ACAP1 for disorders           About GeneDecksing

    OMIM gene information: 607763    OMIM disorders: --

    4 diseases for ACAP1:    About MalaCards
    pituitary adenoma    adenoma    malaria    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: ACAP1 (2 documents)

    Export disorders for ACAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACAP1 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with ACAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ACAPs are arf6 GTPase-activating proteins that function in the cell periphery. (PubMed id 11062263)1, 2, 3, 9 Jackson T.R.... Randazzo P.A. (2000)
    2. Cooperation of phosphoinositides and BAR domain proteins in endosomal tubulation. (PubMed id 17010122)1, 2, 9 Shinozaki-Narikawa N.... Shibasaki Y. (2006)
    3. An ACAP1-containing clathrin coat complex for endocytic recycling. (PubMed id 17664335)1, 2, 9 Li J.... Hsu V.W. (2007)
    4. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PubMed id 16777052)1, 2, 9 Zhan X. and Desiderio D.M. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling. (PubMed id 11050434)1, 3 Jackson T.R....Theibert A.B. (2000)
    7. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2 Nomura N....Tabata S. (1994)
    8. Centaurin beta1 down-regulates nucleotide-binding oligomerization domains 1- and 2-dependent NF-kappaB activation. (PubMed id 17005562)1, 9 Yamamoto-Furusho J.K....Podolsky D.K. (2006)
    9. Mechanistic insights into regulated cargo binding by A CAP1 protein. (PubMed id 22645133)1 Bai M....Hsu V.W. (2012)
    10. The oncogenic TBC domain protein USP6/TRE17 regulates cell migration and cytokinesis. (PubMed id 22188517)1 Rueckert C. and Haucke V. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9744 HGNC: 16467 AceView: CENTB1andKCTD11 Ensembl:ENSG00000072818 euGenes: HUgn9744
    ECgene: ACAP1 Kegg: 9744 H-InvDB: ACAP1

    (According to HUGE)
    About This Section
    HUGE: KIAA0050

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ACAP1 gene:
    Search GeneIP for patents involving ACAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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