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Aliases for ACAN Gene

Aliases for ACAN Gene

  • Aggrecan 2 3
  • MSK16 3 4 6
  • CSPG1 3 4 6
  • AGC1 3 4 6
  • Chondroitin Sulfate Proteoglycan Core Protein 1 3 4
  • Cartilage-Specific Proteoglycan Core Protein 3 4
  • Chondroitin Sulfate Proteoglycan 1 2 4
  • SEDK 3 6
  • Large Aggregating Proteoglycan 3
  • Aggrecan Proteoglycan 2
  • Aggrecan Core Protein 3
  • Aggrecan 1 2
  • CSPGCP 3
  • AGCAN 3
  • CSPCP 4

External Ids for ACAN Gene

Previous Symbols for ACAN Gene

  • MSK16
  • CSPG1
  • AGC1

Summaries for ACAN Gene

Entrez Gene Summary for ACAN Gene

  • This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACAN Gene

ACAN (Aggrecan) is a Protein Coding gene. Diseases associated with ACAN include spondyloepiphyseal dysplasia, kimberley type and spondyloepimetaphyseal dysplasia, aggrecan type. Among its related pathways are Disease and ERK Signaling. GO annotations related to this gene include carbohydrate binding and hyaluronic acid binding. An important paralog of this gene is HAPLN1.

UniProtKB/Swiss-Prot for ACAN Gene

  • This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region

Gene Wiki entry for ACAN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACAN Gene

Genomics for ACAN Gene

Genomic Location for ACAN Gene

88,803,442 bp from pter
88,875,354 bp from pter
71,913 bases
Plus strand

Genomic View for ACAN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACAN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACAN Gene

Regulatory Elements for ACAN Gene

Proteins for ACAN Gene

  • Protein details for ACAN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Aggrecan core protein
    Protein Accession:
    Secondary Accessions:
    • Q13650
    • Q9UCD3
    • Q9UCP4
    • Q9UCP5
    • Q9UDE0

    Protein attributes for ACAN Gene

    2415 amino acids
    Molecular mass:
    250193 Da
    Quaternary structure:
    • Interacts with FBLN1 (By similarity). Interacts with COMP.

    Three dimensional structures from OCA and Proteopedia for ACAN Gene

    Alternative splice isoforms for ACAN Gene


neXtProt entry for ACAN Gene

Proteomics data for ACAN Gene at MOPED

Post-translational modifications for ACAN Gene

  • Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn126, Asn239, Asn333, Thr371, Thr376, Asn387, Asn434, Asn602, Asn657, Asn737, and Asn1898

Other Protein References for ACAN Gene

No data available for DME Specific Peptides for ACAN Gene

Domains for ACAN Gene

Gene Families for ACAN Gene

  • VSET :Immunoglobulin superfamily / V-set domain containing
  • HYALECTAN :Proteoglycans / Extracellular Matrix : Hyalectans

Suggested Antigen Peptide Sequences for ACAN Gene

Graphical View of Domain Structure for InterPro Entry



  • Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3:
    • P16112
  • Contains 1 C-type lectin domain.:
    • P16112
  • Contains 1 EGF-like domain.:
    • P16112
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • P16112
  • Contains 4 Link domains.:
    • P16112
  • Contains 1 Sushi (CCP/SCR) domain.:
    • P16112
  • Belongs to the aggrecan/versican proteoglycan family.:
    • P16112
genes like me logo Genes that share domains with ACAN: view

Function for ACAN Gene

Molecular function for ACAN Gene

UniProtKB/Swiss-Prot Function: This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region

Gene Ontology (GO) - Molecular Function for ACAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent TAS 1569188
GO:0005509 calcium ion binding --
GO:0005515 protein binding IPI 17588949
GO:0005540 hyaluronic acid binding IEA --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with ACAN: view
genes like me logo Genes that share phenotypes with ACAN: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ACAN Gene

Localization for ACAN Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACAN Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for ACAN Gene COMPARTMENTS Subcellular localization image for ACAN gene
Compartment Confidence
extracellular 4
golgi apparatus 4
lysosome 4
vacuole 4
cytoskeleton 2
nucleus 2
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ACAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005604 basement membrane --
GO:0005796 Golgi lumen TAS --
GO:0031012 colocalizes_with extracellular matrix IDA 20551380
genes like me logo Genes that share ontologies with ACAN: view

Pathways for ACAN Gene

genes like me logo Genes that share pathways with ACAN: view

Pathways by source for ACAN Gene

Gene Ontology (GO) - Biological Process for ACAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development NAS 1569188
GO:0001502 cartilage condensation --
GO:0002063 chondrocyte development --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006508 proteolysis NAS 1569188
genes like me logo Genes that share ontologies with ACAN: view

Compounds for ACAN Gene

(1) HMDB Compounds for ACAN Gene

Compound Synonyms Cas Number PubMed IDs
Hyaluronic acid
  • hyaluronic acid

(1) Drugbank Compounds for ACAN Gene

Compound Synonyms Cas Number Type Actions PubMed IDs

(34) Novoseek inferred chemical compound relationships for ACAN Gene

Compound -log(P) Hits PubMed IDs
keratan sulfate 77.9 9
neurocan 72.1 6
glycosaminoglycan 69.9 11
alginate 69.8 9
chondroitin sulfate 68.1 16
genes like me logo Genes that share compounds with ACAN: view

Transcripts for ACAN Gene

Unigene Clusters for ACAN Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACAN Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - - - -
SP2: - - -
SP3: -
SP4: - -
SP5: -

ExUns: 20 ^ 21a · 21b
SP1: -

Relevant External Links for ACAN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACAN Gene

mRNA expression in normal human tissues for ACAN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACAN Gene

This gene is overexpressed in Artery - Tibial (20.7), Artery - Aorta (14.6), and Artery - Coronary (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ACAN Gene

SOURCE GeneReport for Unigene cluster for ACAN Gene Hs.2159

mRNA Expression by UniProt/SwissProt for ACAN Gene

Tissue specificity: Restricted to cartilages.
genes like me logo Genes that share expressions with ACAN: view

Orthologs for ACAN Gene

This gene was present in the common ancestor of chordates.

Orthologs for ACAN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACAN 36
  • 99 (a)
(Bos Taurus)
Mammalia ACAN 36
  • 78 (a)
(Canis familiaris)
Mammalia ACAN 36
  • 78 (a)
(Mus musculus)
Mammalia Acan 16
Acan 36
  • 77 (a)
(Monodelphis domestica)
Mammalia ACAN 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia ACAN 36
  • 51 (a)
(Gallus gallus)
Aves ACAN 36
  • 51 (a)
(Anolis carolinensis)
Reptilia ACAN 36
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia acan 35
  • 59 (n)
  • 59.95 (a)
(Danio rerio)
Actinopterygii acana 36
  • 36 (a)
acanb 35
  • 60.63 (n)
  • 61.69 (a)
acanb 36
  • 44 (a)
Species with no ortholog for ACAN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACAN Gene

Gene Tree for ACAN (if available)
Gene Tree for ACAN (if available)

Paralogs for ACAN Gene

Paralogs for ACAN Gene

genes like me logo Genes that share paralogs with ACAN: view

Variants for ACAN Gene

Sequence variations from dbSNP and Humsavar for ACAN Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs698621 -- 88,859,365(-) ATGGA(A/C/G/T)GCATC synonymous-codon, reference
rs869429 -- 88,834,648(-) TTTAA(A/G)AAGTG intron-variant
rs869430 -- 88,834,576(-) TGGAG(A/C)TTTCA intron-variant
rs869431 -- 88,834,478(-) GCTGG(A/G)GCTGG intron-variant
rs872397 -- 88,834,031(+) CTGCC(C/T)TCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACAN Gene

Variant ID Type Subtype PubMed ID
nsv525114 CNV Loss 19592680
esv2749995 CNV Deletion 23290073
esv2394182 CNV Deletion 18987734
esv28667 CNV Loss 19812545
nsv820918 CNV Deletion 20802225
esv2749997 CNV Deletion 23290073
esv1510077 CNV Deletion 17803354
esv1164464 CNV Deletion 17803354
nsv904478 CNV Loss 21882294
nsv1653 CNV Loss 18451855

Relevant External Links for ACAN Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACAN Gene

Disorders for ACAN Gene

(3) OMIM Diseases for ACAN Gene (155760)


  • Spondyloepiphyseal dysplasia type Kimberley (SEDK) [MIM:608361]: Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy. {ECO:0000269 PubMed:16080123}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Spondyloepimetaphyseal dysplasia aggrecan type (SEMD-ACAN) [MIM:612813]: A bone disease characterized by severe short stature, macrocephaly, severe midface hypoplasia, short neck, barrel chest and brachydactyly. The radiological findings comprise long bones with generalized irregular epiphyses with widened metaphyses, especially at the knees, platyspondyly, and multiple cervical-vertebral clefts. {ECO:0000269 PubMed:19110214}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Osteochondritis dissecans short stature and early-onset osteoarthritis (OD) [MIM:165800]: A type of osteochondritis defined as a separation of cartilage and subchondral bone from the surrounding tissue, primarily affecting the knee, ankle and elbow joints. It is clinically characterized by multiple osteochondritic lesions in knees and/or hips and/or elbows, disproportionate short stature and early-onset osteoarthritis. {ECO:0000269 PubMed:20137779}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(18) Novoseek inferred disease relationships for ACAN Gene

Disease -log(P) Hits PubMed IDs
osteoarthritis 77.8 22
psach 59.3 3
multiple epiphyseal dysplasia 55.6 1
arthritis 53.9 9
inflammatory joint disease 46.4 1

Relevant External Links for ACAN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ACAN: view

Publications for ACAN Gene

  1. Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms. (PMID: 1985970) Doege K.J. … Yamada Y. (J. Biol. Chem. 1991) 2 3 4 23
  2. The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain. (PMID: 1569188) Sandy J.D. … Lohmander L.S. (J. Clin. Invest. 1992) 3 4 23
  3. A mutation in the variable repeat region of the aggrecan gene (AGC1) causes a form of spondyloepiphyseal dysplasia associated with severe, premature osteoarthritis. (PMID: 16080123) Gleghorn L. … Wallis G. (Am. J. Hum. Genet. 2005) 3 4 23
  4. A new epidermal growth factor-like domain in the human core protein for the large cartilage-specific proteoglycan. Evidence for alternative splicing of the domain. (PMID: 2789216) Baldwin C.T. … Prockop D.J. (J. Biol. Chem. 1989) 3 4
  5. Length variation in the keratan sulfate domain of mammalian aggrecan. (PMID: 7827755) Barry F.P. … Pearson D. (Matrix Biol. 1994) 3 4

Products for ACAN Gene

Sources for ACAN Gene

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