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ACAN Gene

protein-coding GIFtS: 56

GC15P087148

aggrecan
(Previous names: chondroitin sulfate proteoglycan 1, aggrecan 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: MSK16, CSPG1, AGC1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AGC1 ^², ³, ⁵
AGCAN ^²
CSPCP ^³
CSPG1 ^², ³, ⁵
CSPGCP ^¹, ²
MSK16 ^², ³, ⁵
SEDK ^², ⁵
aggrecan ^²

Descriptions
Cartilage-specific proteoglycan core protein ^², ³
Chondroitin sulfate proteoglycan core protein 1 ^³
aggrecan 1 ^¹
aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122) ^²
aggrecan proteoglycan ^²
chondroitin sulfate proteoglycan 1 ^¹, ²
large aggregating proteoglycan ^²

External Ids
HGNC: 319¹
Entrez Gene: 176²
UniProtKB: P16112³
Ensembl: ENSG00000157766⁷

Search outside databases for aliases for ACAN gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ACAN:

This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an

integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in

cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration.

Multiple alternatively spliced transcript variants that encode different protein isoforms have

been observed in this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: PGCA_HUMAN, P16112

Function: This proteoglycan is a major component of extracellular matrix of cartilagenous tissues.

A major function of this protein is to resist compression in cartilage. It binds avidly to

hyaluronic acid via an N-terminal globular region

Gene Wiki entry for ACAN (Aggrecan)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1 Ensembl cytogenetic band: 15q26.1 HGNC cytogenetic band: 15q26.1

ACAN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P087148: (about GC identifiers)

Start:	87,147,678 bp from pter
End:	87,219,589 bp from pter
Size:	71,912 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000015.8 NT_010274.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PGCA_HUMAN, P16112 (See protein sequence)

Recommended Name: Aggrecan core protein precursor

Size: 2415 amino acids; 250193 Da

Subunit: Interacts with FBLN1 (By similarity)

Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)

Developmental stage: Expression was detected in chondrocytes throughout the developing skeleton

Secondary accessions: Q13650 Q9UCD3 Q9UCP4 Q9UCP5 Q9UDE0

Alternative splicing: 3 isoforms: P16112-1 P16112-2 P16112-3 (Additional isoforms seem to exist)

Post-translational modifications:

Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked

oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial

fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase¹

View phosphorylation sites using PhosphoSite² (ACAN)

REFSEQ proteins (2 alternative transcripts):

NP_001126.2 NP_037359.2

ENSEMBL proteins:

ENSP00000268134 ENSP00000342398 ENSP00000341615

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant ACAN Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for ACAN (Aggrecan)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Chondroitin-6-Sulfate, Aggrecan FFGxx, Aggrecan ARGxx, Aggrecan, Aggrecan xxPEN)
	Human Recombinant Proteins from Abnova (AGC1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005578	proteinaceous extracellular matrix	IEA	--

About this table

Antibodies for ACAN:

	Invitrogen Antibodies for ACAN
	Millipore Mono- and Polyclonal Antibodies for the study of ACAN
	Sigma-Aldrich Antibody Arrays and Antibodies for ACAN
	R&D Systems Antibodies for ACAN (Aggrecan)
	Antibodies from Abcam (Chondroitin-6-Sulfate, Aggrecan FFGxx, Aggrecan ARGxx, Aggrecan, Aggrecan xxPEN), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (AGC1)
	Novus Biologicals Antibodies for ACAN

Assays for ACAN:

	Invitrogen Assays for ACAN
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P16112

ProtoNet protein and cluster: P16112

5/6 Blocks protein families (see all 6 ):

IPB000436 Sushi domain/SCR domain/CCP module

IPB000538 Link domain

IPB002353 Type II antifreeze protein signature

IPB003599 Immunoglobulin subtype

IPB006210 Type I EGF

UniProtKB/Swiss-Prot: PGCA_HUMAN, P16112

Domain: Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another

globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three

disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The

keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3

Similarity: Belongs to the aggrecan/versican proteoglycan family

Similarity: Contains 1 C-type lectin domain

Similarity: Contains 1 EGF-like domain

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

Similarity: Contains 4 Link domains

Similarity: Contains 1 Sushi (CCP/SCR) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACAN)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AGC1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001135

Applied Biosystems Silencer® siRNAs for ACAN

Sigma-Aldrich siRNA for ACAN

Sigma-Aldrich shRNA for ACAN

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ACAN
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001135
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001135
untagged cDNA clones in CMV expression vector (see all 4): NM_001135

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_013227

UniProtKB/Swiss-Prot: PGCA_HUMAN, P16112

Function: This proteoglycan is a major component of extracellular matrix of cartilagenous tissues.

A major function of this protein is to resist compression in cartilage. It binds avidly to

hyaluronic acid via an N-terminal globular region

15 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Acan):

behavior/neurological	craniofacial	digestive/alimentary	growth/size	hearing/vestibular/ear
homeostasis/metabolism	immune system	lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail
liver/biliary system	nervous system	normal	respiratory system	skeleton

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005488	binding	IEA	--
GO:0005529	sugar binding	IEA	--
GO:0005540	hyaluronic acid binding	ISS	1569188
GO:0030021	extracellular matrix structural constituent conferring compression resistance	ISS	1569188

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for ACAN

5/62 Interacting proteins for ACAN (ENSP00000268134³) via UniProtKB, MINT, and/or STRING (see all 62 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FBLN1	ENSP00000262723³	STRING (score=.974)
TNR	ENSP00000263525³	STRING (score=.972)
GDF5	ENSP00000363489³	STRING (score=.966)
BMP2	ENSP00000368104³	STRING (score=.957)
BMP7	ENSP00000360340³	STRING (score=.956)

About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	NAS	1569188
GO:0006508	proteolysis	NAS	1569188
GO:0007155	cell adhesion	IEA	--
GO:0030198	extracellular matrix organization	ISS	1569188

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ACAN
10/20 Novoseek chemical compound relationships for ACAN gene (see all 20 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
keratan sulfate	77.85	13	14613270 (1), 7556944 (1), 1569188 (1), 10399179 (1) (see all 9)
neurocan	73.46	6	11038354 (2), 15590670 (1), 8907541 (1), 7806222 (1) (see all 5)
chondroitin sulfate	68.56	22	1339285 (3), 16425147 (3), 8226878 (2), 9153261 (1) (see all 10)
glycosaminoglycan	68.50	16	16188468 (2), 18040638 (1), 9854027 (1), 15727891 (1) (see all 9)
adamalysin	67.85	1	17430884 (1)
dermatan	58.40	2	11474365 (1), 12859055 (1)
tgf beta1	48.95	2	18040638 (1), 15979007 (1)
chondroitin	48.63	3	1569188 (1), 18279833 (1), 11474365 (1)
procollagen	45.85	11	9706207 (5), 10459751 (2), 7949393 (1), 7822417 (1) (see all 5)
cesium chloride	36.84	1	1569188 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACAN)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AGC1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001135

Sigma-Aldrich siRNA for ACAN

Sigma-Aldrich shRNA for ACAN

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001135 NM_013227

REFSEQ mRNAs for ACAN gene (2 alternative transcripts):

NM_001135.2 NM_013227.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001135 NM_013227

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001135
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001135
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001135

Additional cDNA sequence:

U13192.1 XM_001714575.1

11 DOTS entries:

DT.97847777 DT.99998115 DT.100817712 DT.99944820 DT.99953727 DT.99947875 DT.95157471 DT.75118357

DT.99950347 DT.95302403 DT.99950968

24/206 AceView cDNA sequences (see all 206 ):

BQ183753 X80278 BQ182672 BQ181248 AI057257 CA445896 BQ044975 CA447468

BF345576 AU279625 BQ181814 BQ182050 BQ004267 CA411752 BQ007885 CA448514

BQ182258 L12234 CA445816 CN479731 AI340067 CN480007 BQ446640 AI312888

Unigene Clusters for ACAN:

Aggrecan

Hs.2159 [show with all ESTs], Hs.711491 [show with all ESTs]

Unigene Representative Sequences: NM_013227, XM_001714575

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ACAN (see all 7 )

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14a	·	14b	·	14c	^	15	^	16	^	17	^	18	^	19	^
SP1:									-		-		-																		-												-		-
SP2:									-		-		-
SP3:																																													-
SP4:																																											-		-
SP5:													-

ExUns:	20	^	21a	·	21b
SP1:	-
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ACAN

3 Ensembl transcripts including schematic representations:

ENST00000268134 ENST00000338824 ENST00000352105

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ACAN expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ACAN

¹ / ²

10 probe-sets matching ACAN gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39207_r_at²	U95-A	1	1.00	1.00	0.67	0.92	--	--	--	--	--
38965_at²	U95-A	1	1.00	1.00	0.39	1.10	--	--	--	--	--
39206_s_at²	U95-A	1	1.00	1.00	0.54	1.23	--	--	--	--	--
207692_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
205679_x_at²	U133-A	3	1.00	0.94	--	--	--	--	--	--	--
217161_x_at²	U133-A	3	1.00	0.94	--	--	--	--	--	--	--
207692_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1554950_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205679_x_at²	U133Plus2	3	1.00	0.94	--	--	--	--	--	--	--
217161_x_at²	U133Plus2	3	1.00	0.94	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.2159 Hs.711491
UniProtKB/Swiss-Prot: PGCA_HUMAN, P16112
Tissue specificity: Restricted to cartilages

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ACAN gene from 1 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
mouse (Mus musculus)	Acan⁵	7 (39.00 cM)	aggrecan	--	X80279

About this table Species with no ortholog for ACAN

ENSEMBL Gene Tree for ACAN

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ACAN gene

BCAN² VCAN²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/523 NCBI SNPs in ACAN are shown (see all 523 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 235)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs938609^1,2	A,C,F,H	87199635(+)	`TGCCCT/ACTGGA`	2	T/S	mis¹ ese³		11	EA NA MN EU WA	838
	rs1042630^1,2	A,C,F,H	87203055(+)	`GGGACG/ATTAGT`	2	V/I	mis¹ ese³		18	EA MN NA EU WA	3152
	rs4932439^1,2	A,C,F,H	87202113(+)	`CAGGTG/ATTAGT`	2	V/I	mis¹		13	EA NA EU WA	1114
	rs938608^1,2	A,C,F,H	87199609(+)	`GCCCAG/TCACTC`	2	S/I	mis¹		9	EA NA EU WA	634
	rs2882676^1,2	A,C,F,H	87201343(-)	`GAAGTT/GCACTG`	2	A/E	mis¹		11	EU EA WA NA	1070
	rs16942411^1,2	C,F,H	87219992(+)	`GGTTGG/ATAGAC`	2	--	ng3¹		11	NA EU EA WA	978
	rs16942318^1,2	C,F,H	87183133(+)	`CAGGAC/AAAGGT`	2	E/D	mis¹		12	NA EU EA WA	1058
	rs3817428^1,2	C,F,H	87216251(-)	`TGGTAG/CTCTTG`	2	E/D	mis¹ ese³		18	EA NS NA EU WA	1904
	rs3743398^1,2	C,F,H	87199411(-)	`CATCAG/AGGGCC`	2	L/P	mis¹ ese³		10	EA EU WA NA	2408
	rs8031741^1,2	C,F,H	87219873(+)	`GTGACA/GTGCGT`	2	--	ng3¹		4	EU EA WA	404

About this table

HapMap Linkage Disequilibrium images for ACAN (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 155760 disorders: 608361

UniProtKB/Swiss-Prot: PGCA_HUMAN, P16112

Defects in ACAN are the cause of spondyloepiphyseal dysplasia type Kimberley (SEDK)

[MIM:608361]. Spondyloepiphyseal dysplasias are a heterogeneous group of congenital

chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is

associated with premature degenerative arthropathy

10/17 Novoseek disease relationships for ACAN gene (see all 17 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
osteoarthritis	76.07	22	8195777 (2), 7533495 (2), 16583443 (2), 12801482 (2) (see all 15)
psach	61.10	3	1670752 (3)
multiple epiphyseal dysplasia	57.35	1	12205105 (1)
arthritis	55.98	9	14613270 (3), 8941646 (3), 8603731 (1), 10438522 (1) (see all 5)
inflammatory joint disease	48.37	1	9485085 (1)
spondyloepiphyseal dysplasia	46.52	3	12205105 (1), 16080123 (1)
collagen fibril	37.72	2	8195777 (1), 8456642 (1)
chondrosarcoma	34.62	1	8226878 (1)
dwarfism	31.26	1	12975605 (1)
achondroplasia	29.86	3	1670752 (3)

About this table

Human Gene Mutation Database: ACAN
Human Genome Epidemiology Navigator: ACAN (8 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/285 PubMed articles for ACAN gene (see all 285 ):

Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms. (PubMed id 1985970)^{1, 2, 3, 4} Doege K.J.... Yamada Y. (1991)
A mutation in the variable repeat region of the aggrecan gene (AGC1) causes a form of spondyloepiphyseal dysplasia associated with severe, premature osteoarthritis. (PubMed id 16080123)^{1, 3, 4} Gleghorn L.... Wallis G. (2005)
The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain. (PubMed id 1569188)^{1, 3, 4} Sandy J.D.... Lohmander L.S. (1992)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{3, 4} Liu T.... Smith R.D. (2005)
Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage. (PubMed id 8611178)^{3, 4} Dudhia J....Bayliss M.T. (1996)
Catabolism of aggrecan by explant cultures of human articular cartilage in the presence of retinoic acid. (PubMed id 7574678)^{3, 4} Ilic M.Z....Handley C.J. (1995)
Analysis of aggrecan and tenascin gene expression in mouse skeletal tissues by northern and in situ hybridization using species specific cDNA probes. (PubMed id 7524681)^{3, 4} Glumoff V.... Vuorio E. (1994)
Length variation in the keratan sulfate domain of mammalian aggrecan. (PubMed id 7827755)^{3, 4} Barry F.P.... Pearson D. (1994)
A new epidermal growth factor-like domain in the human core protein for the large cartilage-specific proteoglycan. Evidence for alternative splicing of the domain. (PubMed id 2789216)^{3, 4} Baldwin C.T.... Prockop D.J. (1989)
The involvement of aggrecan polymorphism in degeneration of human intervertebral disc and articular cartilage. (PubMed id 16425147)^{1, 3} Roughley P....Antoniou J. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 176	HGNC: 319	AceView: AGC1	Ensembl:ENSG00000157766	euGenes: HUgn176
ECgene: ACAN	H-InvDB: ACAN

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_351

Licensable Technologies for ACAN
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ACAN:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
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	Predesigned and custom siRNAs for ACAN		Antibodies for ACAN
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	Recombinant Proteins (Chondroitin-6-Sulfate, Aggrecan FFGxx, Aggrecan ARGxx, Aggrecan, Aggrecan xxPEN)
	Antibodies (Chondroitin-6-Sulfate, Aggrecan FFGxx, Aggrecan ARGxx, Aggrecan, Aggrecan xxPEN)

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Antibodies for ACAN

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ACAN Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for ACAN

Summaries
for ACAN

Genomic Location
for ACAN

Proteins
for ACAN

Protein Domains/
Families
for ACAN

Gene Function
for ACAN

Pathways & Interactions
for ACAN

Drugs & Compounds
for ACAN

Transcripts
for ACAN

Expression
for ACAN

Orthologs
for ACAN

Paralogs
for ACAN

SNPs/Variants
for ACAN

Disorders & Mutations
for ACAN

Medical News
for ACAN

Publications
for ACAN

Search for ACAN

Genome Databases showing ACAN

Other Databases showing ACAN

Specialized Databases showing ACAN

Licensable Technologies
for ACAN

Services
for ACAN

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ACAN Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor ACAN

Summariesfor ACAN

Genomic Locationfor ACAN

Proteinsfor ACAN

Protein Domains/Familiesfor ACAN

Gene Functionfor ACAN

Pathways & Interactionsfor ACAN

Drugs & Compoundsfor ACAN

Transcriptsfor ACAN

Expression for ACAN

Orthologsfor ACAN

Paralogsfor ACAN

SNPs/Variantsfor ACAN

Disorders & Mutationsfor ACAN

Medical Newsfor ACAN

Publicationsfor ACAN

Search for ACAN

Genome Databases showing ACAN

Other Databases showing ACAN

Specialized Databases showing ACAN

Licensable Technologiesfor ACAN

Servicesfor ACAN

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ACAN

Summaries
for ACAN

Genomic Location
for ACAN

Proteins
for ACAN

Protein Domains/
Families
for ACAN

Gene Function
for ACAN

Pathways & Interactions
for ACAN

Drugs & Compounds
for ACAN

Transcripts
for ACAN

Expression
for ACAN

Orthologs
for ACAN

Paralogs
for ACAN

SNPs/Variants
for ACAN

Disorders & Mutations
for ACAN

Medical News
for ACAN

Publications
for ACAN

Licensable Technologies
for ACAN

Services
for ACAN