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ACAN Gene

protein-coding   GIFtS: 56

GC15P087148
aggrecan
(Previous names: chondroitin sulfate proteoglycan 1, aggrecan 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: MSK16, CSPG1, AGC1)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
AGC1 2, 3, 5
AGCAN 2
CSPCP 3
CSPG1 2, 3, 5
CSPGCP 1, 2
MSK16 2, 3, 5
SEDK 2, 5
aggrecan 2
Descriptions
Cartilage-specific proteoglycan core protein 2, 3
Chondroitin sulfate proteoglycan core protein 1 3
aggrecan 1 1
aggrecan 1 (chondroitin sulfate proteoglycan 1, large
aggregating proteoglycan, antigen identified by monoclonal
antibody A0122) 2
aggrecan proteoglycan 2
chondroitin sulfate proteoglycan 1 1, 2
large aggregating proteoglycan 2
External Ids
HGNC: 3191
Entrez Gene: 1762
UniProtKB: P161123
Ensembl: ENSG000001577667
Search outside databases for aliases for ACAN gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ACAN:
This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an
integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in
cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration.
Multiple alternatively spliced transcript variants that encode different protein isoforms have
been observed in this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: PGCA_HUMAN, P16112
Function: This proteoglycan is a major component of extracellular matrix of cartilagenous tissues.
A major function of this protein is to resist compression in cartilage. It binds avidly to
hyaluronic acid via an N-terminal globular region

Gene Wiki entry for ACAN (Aggrecan)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

ACAN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P087148:     (about GC identifiers)

Start:
87,147,678 bp from pter
End:
87,219,589 bp from pter
Size:
71,912 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000015.8  NT_010274.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PGCA_HUMAN, P16112 (See protein sequence)
Recommended Name: Aggrecan core protein precursor  
Size: 2415 amino acids; 250193 Da
Subunit: Interacts with FBLN1 (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Developmental stage: Expression was detected in chondrocytes throughout the developing skeleton
Secondary accessions: Q13650 Q9UCD3 Q9UCP4 Q9UCP5 Q9UDE0
Alternative splicing: 3 isoforms:  P16112-1   P16112-2   P16112-3   (Additional isoforms seem to exist)

Post-translational modifications:

  • Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked
    oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial
    fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase1
  • View phosphorylation sites using PhosphoSite2 (ACAN)


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001126.2  NP_037359.2  


    ENSEMBL proteins: 
    ENSP00000268134 ENSP00000342398 ENSP00000341615 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Millipore Purified and/or Recombinant ACAN Protein
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    R&D Systems Recombinant & Natural Proteins for ACAN (Aggrecan)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Chondroitin-6-Sulfate, Aggrecan FFGxx, Aggrecan ARGxx, Aggrecan, Aggrecan xxPEN)
    Human Recombinant Proteins from Abnova (AGC1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005578 proteinaceous extracellular matrix IEA--
    About this table

    Antibodies for ACAN: 
    Invitrogen Antibodies for ACAN
    Millipore Mono- and Polyclonal Antibodies for the study of ACAN
    Sigma-Aldrich Antibody Arrays and Antibodies for ACAN
    R&D Systems Antibodies for ACAN (Aggrecan)
    Antibodies from Abcam (Chondroitin-6-Sulfate, Aggrecan FFGxx, Aggrecan ARGxx, Aggrecan, Aggrecan xxPEN), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (AGC1)
    Novus Biologicals Antibodies for ACAN

    Assays for ACAN: 
    Invitrogen Assays for ACAN
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/15 InterPro domains/families (see all 15 ):
     IPR007110 Ig-like
     IPR003006 Ig/MHC_CS
     IPR003599 Ig_sub
     IPR016060 Complement_control_module
     IPR000742 EGF_3


       GeneDecks  ACAN for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P16112

    ProtoNet protein and cluster: P16112

    5/6 Blocks protein families (see all 6 ):
    IPB000436 Sushi domain/SCR domain/CCP module
    IPB000538 Link domain
    IPB002353 Type II antifreeze protein signature
    IPB003599 Immunoglobulin subtype
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: PGCA_HUMAN, P16112
    Domain: Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another
    globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three
    disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The
    keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3
    Similarity: Belongs to the aggrecan/versican proteoglycan family
    Similarity: Contains 1 C-type lectin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain
    Similarity: Contains 4 Link domains
    Similarity: Contains 1 Sushi (CCP/SCR) domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ACAN)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (AGC1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001135

                  Applied Biosystems Silencer® siRNAs for ACAN

                  Sigma-Aldrich siRNA for ACAN  
                         Sigma-Aldrich shRNA for ACAN  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ACAN
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001135
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001135
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_001135 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_013227

    UniProtKB/Swiss-Prot: PGCA_HUMAN, P16112
    Function: This proteoglycan is a major component of extracellular matrix of cartilagenous tissues.
    A major function of this protein is to resist compression in cartilage. It binds avidly to
    hyaluronic acid via an N-terminal globular region

    15 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Acan):

    behavior/neurologicalcraniofacialdigestive/alimentarygrowth/sizehearing/vestibular/ear
    homeostasis/metabolismimmune systemlethality-prenatal/perinatallife span-post-weaning/aginglimbs/digits/tail
    liver/biliary systemnervous systemnormalrespiratory systemskeleton

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488 binding IEA--
    GO:0005529 sugar binding IEA--
    GO:0005540 hyaluronic acid binding ISS1569188
    GO:0030021 extracellular matrix structural constituent conferring compression resistance ISS1569188
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    1 Invitrogen iPath™ Online BioAtlas - Pathway for ACAN (Maps provided by GeneGo):
     Cell-matrix glycoconjugates

       GeneDecks  ACAN for the pathways selected above  
    About GeneDecksing

    2 Millipore Pathways for ACAN
     Cell adhesion Cell-matrix glycoconjugates
     Metalloproteases in connective tissue degradation

       GeneDecks  ACAN for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  ACAN 


    5/62 Interacting proteins for ACAN (ENSP000002681343) via UniProtKB, MINT, and/or STRING (see all 62 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FBLN1ENSP000002627233STRING (score=.974)
    TNRENSP000002635253STRING (score=.972)
    GDF5ENSP000003634893STRING (score=.966)
    BMP2ENSP000003681043STRING (score=.957)
    BMP7ENSP000003603403STRING (score=.956)
    About this table

    4 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501 skeletal system development NAS1569188
    GO:0006508 proteolysis NAS1569188
    GO:0007155 cell adhesion IEA--
    GO:0030198 extracellular matrix organization ISS1569188
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ACAN
    10/20 Novoseek chemical compound relationships for ACAN gene (see all 20 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    keratan sulfate 77.85 13 14613270 (1), 7556944 (1), 1569188 (1), 10399179 (1) (see all 9)
    neurocan 73.46 6 11038354 (2), 15590670 (1), 8907541 (1), 7806222 (1) (see all 5)
    chondroitin sulfate 68.56 22 1339285 (3), 16425147 (3), 8226878 (2), 9153261 (1) (see all 10)
    glycosaminoglycan 68.50 16 16188468 (2), 18040638 (1), 9854027 (1), 15727891 (1) (see all 9)
    adamalysin 67.85 1 17430884 (1)
    dermatan 58.40 2 11474365 (1), 12859055 (1)
    tgf beta1 48.95 2 18040638 (1), 15979007 (1)
    chondroitin 48.63 3 1569188 (1), 18279833 (1), 11474365 (1)
    procollagen 45.85 11 9706207 (5), 10459751 (2), 7949393 (1), 7822417 (1) (see all 5)
    cesium chloride 36.84 1 1569188 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ACAN)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (AGC1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001135

                  Sigma-Aldrich siRNA for ACAN  
                         Sigma-Aldrich shRNA for ACAN  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001135  NM_013227  

    REFSEQ mRNAs for ACAN gene (2 alternative transcripts): 

    NM_001135.2   NM_013227.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001135  NM_013227  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001135
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001135
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_001135 

    Additional cDNA sequence: 

    U13192.1 XM_001714575.1 

    11 DOTS entries:

    DT.97847777  DT.99998115  DT.100817712  DT.99944820  DT.99953727  DT.99947875  DT.95157471  DT.75118357 
    DT.99950347  DT.95302403  DT.99950968 

    24/206 AceView cDNA sequences (see all 206 ):

    BQ183753 X80278 BQ182672 BQ181248 AI057257 CA445896 BQ044975 CA447468 
    BF345576 AU279625 BQ181814 BQ182050 BQ004267 CA411752 BQ007885 CA448514 
    BQ182258 L12234 CA445816 CN479731 AI340067 CN480007 BQ446640 AI312888 

    Unigene Clusters for ACAN:

    Aggrecan
    Hs.2159  [show with all ESTs], Hs.711491  [show with all ESTs]
    Unigene Representative Sequences: NM_013227, XM_001714575


    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ACAN (see all 7 )

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                          -     -     -                                                     -                                   -     -                     
    SP2:                          -     -     -                                                                                                                     
    SP3:                                                                                                                                      -                     
    SP4:                                                                                                                                -     -                     
    SP5:                                      -                                                                                                                     

    ExUns: 20 ^ 21a · 21b
    SP1:  -               
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  

    About this scheme

    ECgene alternative splicing isoforms for ACAN

    3 Ensembl transcripts including schematic representations:
    ENST00000268134  ENST00000338824  ENST00000352105  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ACAN expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ACAN

    1 / 2

    10 probe-sets matching ACAN gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    39207_r_at2 U95-A 1 1.00 1.00 0.67 0.92 -- -- -- -- --

    38965_at2 U95-A 1 1.00 1.00 0.39 1.10 -- -- -- -- --

    39206_s_at2 U95-A 1 1.00 1.00 0.54 1.23 -- -- -- -- --

    207692_s_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

    205679_x_at2 U133-A 3 1.00 0.94 -- -- -- -- -- -- --

    217161_x_at2 U133-A 3 1.00 0.94 -- -- -- -- -- -- --

    207692_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1554950_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    205679_x_at2 U133Plus2 3 1.00 0.94 -- -- -- -- -- -- --

    217161_x_at2 U133Plus2 3 1.00 0.94 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene clusters: Hs.2159 Hs.711491

    UniProtKB/Swiss-Prot: PGCA_HUMAN, P16112
    Tissue specificity: Restricted to cartilages

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ACAN gene from 1 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    mouse
    (Mus musculus)
    Acan5 7 (39.00 cM) aggrecan   -- X80279 
    About this table        Species with no ortholog for ACAN

    ENSEMBL Gene Tree for ACAN
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ACAN gene
    BCAN2  VCAN2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/523 NCBI SNPs in ACAN are shown (see all 523 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 235)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 15 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs9386091,2
    A,C,F,H87199635(+) TGCCCT/ACTGGA 2 T/S mis1 ese311Minor allele frequency- A:0.49EA NA MN EU WA 838
    rs10426301,2
    A,C,F,H87203055(+) GGGACG/ATTAGT 2 V/I mis1 ese318Minor allele frequency- A:0.43EA MN NA EU WA 3152
    rs49324391,2
    A,C,F,H87202113(+) CAGGTG/ATTAGT 2 V/I mis113Minor allele frequency- A:0.30EA NA EU WA 1114
    rs9386081,2
    A,C,F,H87199609(+) GCCCAG/TCACTC 2 S/I mis19Minor allele frequency- A:0.03EA NA EU WA 634
    rs28826761,2
    A,C,F,H87201343(-) GAAGTT/GCACTG 2 A/E mis111Minor allele frequency- G:0.40EU EA WA NA 1070
    rs169424111,2
    C,F,H87219992(+) GGTTGG/ATAGAC 2 -- ng3111Minor allele frequency- A:0.02NA EU EA WA 978
    rs169423181,2
    C,F,H87183133(+) CAGGAC/AAAGGT 2 E/D mis112Minor allele frequency- A:0.05NA EU EA WA 1058
    rs38174281,2
    C,F,H87216251(-) TGGTAG/CTCTTG 2 E/D mis1 ese318Minor allele frequency- C:0.14EA NS NA EU WA 1904
    rs37433981,2
    C,F,H87199411(-) CATCAG/AGGGCC 2 L/P mis1 ese310Minor allele frequency- A:0.17EA EU WA NA 2408
    rs80317411,2
    C,F,H87219873(+) GTGACA/GTGCGT 2 -- ng314Minor allele frequency- G:0.18EU EA WA 404
    About this table

    HapMap Linkage Disequilibrium images for ACAN (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 155760   disorders: 608361  

    UniProtKB/Swiss-Prot: PGCA_HUMAN, P16112

  • Defects in ACAN are the cause of spondyloepiphyseal dysplasia type Kimberley (SEDK)
    [MIM:608361]. Spondyloepiphyseal dysplasias are a heterogeneous group of congenital
    chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is
    associated with premature degenerative arthropathy
  • 10/17 Novoseek disease relationships for ACAN gene (see all 17 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteoarthritis 76.07 22 8195777 (2), 7533495 (2), 16583443 (2), 12801482 (2) (see all 15)
    psach 61.10 3 1670752 (3)
    multiple epiphyseal dysplasia 57.35 1 12205105 (1)
    arthritis 55.98 9 14613270 (3), 8941646 (3), 8603731 (1), 10438522 (1) (see all 5)
    inflammatory joint disease 48.37 1 9485085 (1)
    spondyloepiphyseal dysplasia 46.52 3 12205105 (1), 16080123 (1)
    collagen fibril 37.72 2 8195777 (1), 8456642 (1)
    chondrosarcoma 34.62 1 8226878 (1)
    dwarfism 31.26 1 12975605 (1)
    achondroplasia 29.86 3 1670752 (3)
    About this table

    Human Gene Mutation Database: ACAN
    Human Genome Epidemiology Navigator: ACAN (8 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/285 PubMed articles for ACAN gene (see all 285 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 176 HGNC: 319 AceView: AGC1 Ensembl:ENSG00000157766 euGenes: HUgn176
    ECgene: ACAN H-InvDB: ACAN
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_351
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ACAN:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ACAN-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for ACAN Antibodies for ACAN
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for ACAN Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (AGC1)
     Antibodies (AGC1)
     Chimera RNAi (AGC1)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (Chondroitin-6-Sulfate, Aggrecan FFGxx, Aggrecan ARGxx, Aggrecan, Aggrecan xxPEN)
     Antibodies (Chondroitin-6-Sulfate, Aggrecan FFGxx, Aggrecan ARGxx, Aggrecan, Aggrecan xxPEN)
     Search OriGene for ACAN
     Search Tocris compounds for ACAN




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for ACAN

    GeneCards Homepage    -    Last full update: 1 Jul 2009        Incremental update: 13 Oct 2009

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