V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

ACADM Gene

protein-coding GIFtS: 63

GC01P075902

acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ACAD1 ^¹, ²
EC 1.3.99.3 ^³
FLJ18227 ^²
FLJ93013 ^²
FLJ99884 ^²
MCAD ^¹, ², ³, ⁵
MCADH ^¹, ²
OTTHUMP00000011345 ^²

Descriptions
acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain ^²
medium-chain acyl-CoA dehydrogenase ^²
medium-chain specific acyl-CoA dehydrogenase ^²

External Ids
HGNC: 89¹
Entrez Gene: 34²
UniProtKB: P11310³
Ensembl: ENSG00000117054⁷

Search outside databases for aliases for ACADM gene

Previous GC identifers: GC01P076309 GC01P075125 GC01P075606 GC01P075612

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ACADM:

This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A

dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid

beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency,

a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which

can result in infantile death. Alternatively spliced transcript variants encoding different

isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: ACADM_HUMAN, P11310

Function: This enzyme is specific for acyl chain lengths of 4 to 16

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ACADM gene

Entrez Gene cytogenetic band: 1p31 Ensembl cytogenetic band: 1p31.1 HGNC cytogenetic band: 1p31

ACADM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P075902: (about GC identifiers)

Start:	75,962,870 bp from pter
End:	76,001,771 bp from pter
Size:	38,902 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_032977.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ACADM_HUMAN, P11310 (See protein sequence)

Recommended Name: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

Size: 421 amino acids; 46588 Da

Cofactor: FAD

Subunit: Homotetramer. Interacts with the heterodimeric electron transfer flavoprotein ETF

Subcellular location: Mitochondrion matrix

Miscellaneous: A number of straight-chain acyl-CoA dehydrogenases of different substrate

specificities are present in mammalian tissues

Miscellaneous: Utilizes the electron transfer flavoprotein (ETF) as electron acceptor that

transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone

oxidoreductase (ETF dehydrogenase)

PDB structures from and Proteopedia :

1EGC (3D)

1EGD (3D)

1EGE (3D)

1T9G (3D)

2A1T (3D)

Secondary accessions: Q9NYF1

REFSEQ proteins (2 alternative transcripts):

NP_000007.1 NP_001120800.1

ENSEMBL proteins:

ENSP00000359871 ENSP00000359878

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ACADM)
	Human Recombinant Proteins from Abnova (ACADM)

OriGene Purified Recombinant Human Protein: ACADM

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	TAS	1731887
GO:0005759	mitochondrial matrix	IEA	--

About this table

Antibodies for ACADM:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ACADM
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ACADM), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ACADM)
	Novus Biologicals Antibodies for ACADM

Assays for ACADM:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P11310

ProtoNet protein and cluster: P11310

1 Blocks protein family: IPB006089 Acyl-CoA dehydrogenase

UniProtKB/Swiss-Prot: ACADM_HUMAN, P11310

Similarity: Belongs to the acyl-CoA dehydrogenase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACADM)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ACADM)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000016

Applied Biosystems Silencer® siRNAs for ACADM

Sigma-Aldrich siRNA and siRNA Panels for ACADM

Sigma-Aldrich shRNA for ACADM

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ACADM
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000016
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000016
untagged cDNA clones in CMV expression vector (see all 2): NM_000016

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001127328

UniProtKB/Swiss-Prot: ACADM_HUMAN, P11310

Function: This enzyme is specific for acyl chain lengths of 4 to 16

Catalytic activity: Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

Enzyme Number (IUBMB): EC 1.3.99.3

Genatlas biochemistry entry for ACADM:

acyl-CoA dehydrogenase,medium chain (C6-C12),mitochondrial,fatty acid beta-oxidation

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Acadm):

homeostasis/metabolism

lethality-postnatal

liver/biliary system

muscle

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003995	acyl-CoA dehydrogenase activity	IMP	2393404
GO:0009055	electron carrier activity	IEA	--
GO:0050660	FAD binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for ACADM (Your Favorite Gene powered by Ingenuity) (see all 6 )

Valine, Leucine and Isoleucine Degradation
Methane Metabolism
Propanoate Metabolism
&beta
Fatty Acid Metabolism

GeneDecks ACADM for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: ACADM_HUMAN, P11310

Pathway: Lipid metabolism; mitochondrial fatty acid beta-oxidation

Gene Network Central^TM Interacting Genes and Proteins Network for ACADM

5/37 Interacting proteins for ACADM (ENSP00000359871³) via UniProtKB, MINT, and/or STRING (see all 37 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HADHA	ENSP00000370023³	STRING (score=.975)
ETFB	ENSP00000346173³	STRING (score=.972)
ETFA	ENSP00000267950³	STRING (score=.962)
CPT1A	ENSP00000265641³	STRING (score=.958)
ACAT1	ENSP00000265838³	STRING (score=.95)

About this table

5/12 Gene Ontology (GO) biological process terms (links to tree view) (see all 12 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001889	liver development	IEA	--
GO:0006082	organic acid metabolic process	IEA	--
GO:0006629	lipid metabolic process	IEA	--
GO:0006631	fatty acid metabolic process	IEA	--
GO:0006635	fatty acid beta-oxidation	IMP	2393404

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ACADM
10/28 Novoseek chemical compound relationships for ACADM gene (see all 28 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
acyl-coa	97.32	323	2345678 (3), 1363805 (3), 8102510 (2), 7905878 (2) (see all 99)
cis-4-decenoic acid	95.40	4	8154855 (1), 8056418 (1), 7586519 (1), 17987455 (1)
octanoylcarnitine	95.00	17	8496747 (3), 9365395 (3), 1635814 (2), 8650121 (1) (see all 11)
3-phenylpropionylglycine	94.74	8	1541011 (3), 2345678 (1), 8419594 (1), 8154855 (1) (see all 5)
suberylglycine	92.89	1	18203188 (1)
hexanoylglycine	87.11	2	18203188 (1), 17186412 (1)
methylenecyclopropyl acetyl-coa	86.73	7	2331485 (2)
hexanoylcarnitine	86.73	2	1635814 (2)
iacoa	85.36	1	8218225 (1)
decanoylcarnitine	83.46	2	8650121 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACADM)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ACADM)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000016

Sigma-Aldrich siRNA and siRNA Panels for ACADM

Sigma-Aldrich shRNA for ACADM

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000016 NM_001127328

REFSEQ mRNAs for ACADM gene (2 alternative transcripts):

NM_000016.4 NM_001127328.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000016 NM_001127328

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000016
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000016
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000016

Additional cDNA sequence:

AF251043.1 AK296045.1 AK301005.1 AK301039.1 AK301717.1 AK311022.1 AK312629.1 AK315946.1

BC005377.1 BX647734.1 CR596485.1 CR620592.1 M16827.1

24/27 DOTS entries (see all 27 ):

DT.100677108 DT.100826152 DT.95189114 DT.216019 DT.100826150 DT.92447986 DT.92447991 DT.100826151

DT.95189097 DT.75200023 DT.92447983 DT.95189110 DT.100826147 DT.91806631 DT.95189109 DT.100684055

DT.100842964 DT.102830966 DT.121438492 DT.121438522 DT.446425 DT.95189108 DT.95189115 DT.97859460

24/271 AceView cDNA sequences (see all 271 ):

BI712079 AU076842 AI078274 AA278487 BQ277570 BG394024 M16827 BU742862

CR620592 BM541774 AF251043 BM972772 BP376935 BG698034 BC005377 BM711350

BP340754 BM465719 BU742405 F07266 T23877 NM_000016 F03536 BU145415

highest scoring ESTs for ACADM:

AA126940 AA197245 AA505399 AA523261 AA651932 AA683551 AA766846 AA815041 AA856613 AI078274

Unigene Cluster for ACADM:

Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain

Hs.445040 [show with all ESTs]

Unigene Representative Sequence: NM_001127328

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ACADM (see all 8 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4	^	5a	·	5b	·	5c	·	5d	^	6	^	7a	·	7b	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12a	·	12b	^	13
SP1:									-								-		-		-		-				-																		-
SP2:																	-		-		-		-				-																		-
SP3:									-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ACADM

2 Ensembl transcripts including schematic representations:

ENST00000370834 ENST00000370841

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ACADM expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ACADM

¹ / ² / ³

3 probe-sets matching ACADM gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37532_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M91432	0.20	1.00	0.72	1
202502_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000016	0.60	1.00	0.82	1
202502_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGCCAGCGAT

SOURCE GeneReport for Unigene cluster: Hs.445040
Expression variation in blood from EXPOLDB for ACADM

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ACADM gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ACADM¹	--	acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight more	90.59(n) 90.75(a)	490207 XM_547328.2 XP_547328.2
chimpanzee (Pan troglodytes)	ACADM¹	--	acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight more	99.68(n) 99.52(a)	469356 XM_524741.2 XP_524741.2
cow (Bos taurus)	ACADM¹	--	acyl-coenzyme A dehydrogenase, C-4 to C-12 straight more	90.63(n) 90.95(a)	505968 NM_001075235.1 NP_001068703.1
rat (Rattus norvegicus)	Acadm¹	--	acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight more	81.87(n) 86.46(a)	24158 NM_016986.1 NP_058682.1
mouse (Mus musculus)	Acadm^{1, 5}	3 (73.60 cM)⁵	acyl-Coenzyme A dehydrogenase, medium chain^{1, 5}	82.42(n)¹ 87.89(a)¹	11364¹ NM_007382.2¹ NP_031408.1¹ AK079930⁵ AK131793⁵ (see all 14)

About this table Species with no ortholog for ACADM

ENSEMBL Gene Tree for ACADM

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ACADM gene

ACADS² ACAD8²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/341 NCBI SNPs in ACADM are shown (see all 341 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 91)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1251078^1,2	A,C,F,H,O	75962076(-)	`TTATAC/GTGTGT`	1	--	ng5¹		11		MN EU EA WA NA	2590
	rs1251079^1,2	A,C,F,H,O	75962033(-)	`GCGCTG/ATATTC`	1	--	ng5¹		19		EU EA WA NA MN	3306
	rs8763^1,2	C,F,H,O	76001708(+)	`CACAAC/TCTCAT`	2	--	ut3¹		17		MN NA EA EU WA	1650
	rs1146587^1,2	A,C,F	76001914(-)	`TCTGAG/AGTCTT`	2	--	ut3¹		3		NA	142
	rs11809592^1,2	C,F,H	75961945(+)	`CCACCA/TCCACT`	1	--	ng5¹		4		EU EA WA	410
	rs1251077^1,2	A,C,F	75962333(-)	`TATGCC/GGGTGC`	1	--	ng5¹		3		MN EA	560
	rs11801489^1,2	C,F,H	75961903(+)	`AATTCC/TTAATC`	1	--	ng5¹		4		EU EA WA	400
	rs12093452^1,2	F,H	75961095(+)	`gtaacG/Aatggt`	1	--	ng5¹		4		EU EA WA	404
--	rs11549026^1,2	H	75970982(+)	`TCATCC/ACAGTG`	2	T/P	mis¹ ese³		4		EU EA WA	406
	rs17848065^1,2	C	76001075(+)	`CACAAA/GCCACT`	2	--	ut3¹ ese³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for ACADM (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 607008 disorders: 201450

UniProtKB/Swiss-Prot: ACADM_HUMAN, P11310

Defects in ACADM are the cause of medium-chain acyl-CoA dehydrogenase deficiency (MCAD

deficiency) [MIM:201450]. It is an autosomal recessive disease which causes fasting hypoglycemia,

hepatic dysfunction, and encephalopathy, often resulting in death in infancy. The disease

frequency is one in 13000

10/28 Novoseek disease relationships for ACADM gene (see all 28 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mcad deficiency	99.54	515	9797589 (9), 18188679 (8), 9365395 (7), 8488845 (7) (see all 99)
scad deficiency	88.04	3	11524729 (1), 18836889 (1)
reye-like syndrome	77.26	3	11763681 (1), 1601002 (1), 1775402 (1)
reye syndrome	74.18	6	12892042 (2), 2279505 (1), 8840534 (1), 2387217 (1) (see all 5)
sudden infant death syndrome	72.60	21	15466077 (3), 16617370 (1), 8840534 (1), 2387217 (1) (see all 15)
metabolic disorder	71.71	24	8033926 (2), 10913960 (1), 12487544 (1), 1570195 (1) (see all 22)
aciduria organic	69.89	1	2208722 (1)
phenylketonurias	65.26	6	16984060 (1), 19191006 (1), 11392180 (1), 15559414 (1) (see all 5)
multiple carboxylase deficiency	63.07	1	11400759 (1)
hypoglycemia	62.94	13	2387217 (2), 7929823 (2), 9498103 (1), 1594327 (1) (see all 11)

About this table

Genatlas disease: ACADM

dicarboxylic aciduria,non ketotic hypoglycemia,Reye-like syndrome,sudden infant death syndrome

GeneTests: ACADM

Medium Chain Acyl-Coenzyme A Dehydrogenase Deficiency

Human Gene Mutation Database: ACADM
Genetic Association Database: ACADM
Human Genome Epidemiology Navigator: ACADM (12 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/250 PubMed articles for ACADM gene (see all 250 ):

Medium-chain acyl-CoA dehydrogenase (MCAD) mutations identified by MS/MS-based prospective screening of newborns differ from those observed in patients with clinical symptoms: identification and characterization of a new, prevalent mutation that results in mild MCAD deficiency. (PubMed id 11349232)^{1, 3, 4, 6} Andresen B.S.... Gregersen N. (2001)
Nucleotide sequence of medium-chain acyl-CoA dehydrogenase mRNA and its expression in enzyme-deficient human tissue. (PubMed id 3035565)^{2, 3, 4} Kelly D.P....Strauss A.W. (1987)
Molecular characterization of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency: identification of a lys329 to glu mutation in the MCAD gene, and expression of inactive mutant enzyme protein in E. coli. (PubMed id 1902818)^{1, 3, 4} Gregersen N.... Ghisla S. (1991)
Structural organization and regulatory regions of the human medium-chain acyl-CoA dehydrogenase gene. (PubMed id 1731887)^{1, 3, 4} Zhang Z.F....Strauss A.W. (1992)
The molecular basis of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency in compound heterozygous patients: is there correlation between genotype and phenotype? (PubMed id 9158144)^{1, 3, 4} Andresen B.S.... Gregersen N. (1997)
A novel mutation in medium chain acyl-CoA dehydrogenase causes sudden neonatal death. (PubMed id 7929823)^{1, 3, 4} Brackett J.C.... Strauss A.W. (1994)
Molecular characterization of inherited medium-chain acyl-CoA dehydrogenase deficiency. (PubMed id 2251268)^{1, 3, 4} Kelly D.P.... Strauss A.W. (1990)
Molecular and functional characterization of mild MCAD deficiency. (PubMed id 11409868)^{1, 3, 4} Zschocke J....Mayatepek E. (2001)
Disease-causing mutations in exon 11 of the medium-chain acyl-CoA dehydrogenase gene. (PubMed id 8198141)^{1, 3, 4} Andresen B.S.... Gregersen N. (1994)
Mutations in the medium chain acyl-CoA dehydrogenase (MCAD) gene. (PubMed id 1363805)^{1, 3, 4} Tanaka K....Chen Y.-T. (1992)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 34	HGNC: 89	AceView: ACADM	Ensembl:ENSG00000117054	euGenes: HUgn34
ECgene: ACADM	H-InvDB: ACADM

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=ACADM

Licensable Technologies for ACADM
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ACADM:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ACADM-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ACADM		Antibodies for ACADM
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ACADM		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ACADM)
	Antibodies (ACADM)
	Chimera RNAi (ACADM)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (ACADM)
	Antibodies (ACADM)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for ACADM

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ACADM

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ACADM Gene at Home site.
Version 2.41.1
server5.xennexinc.com

ACADM Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for ACADM

Summaries
for ACADM

Genomic Location
for ACADM

Proteins
for ACADM

Protein Domains/
Families
for ACADM

Gene Function
for ACADM

Pathways & Interactions
for ACADM

Drugs & Compounds
for ACADM

Transcripts
for ACADM

Expression
for ACADM

Orthologs
for ACADM

Paralogs
for ACADM

SNPs/Variants
for ACADM

Disorders & Mutations
for ACADM

Medical News
for ACADM

Publications
for ACADM

Search for ACADM

Genome Databases showing ACADM

Other Databases showing ACADM

Specialized Databases showing ACADM

Licensable Technologies
for ACADM

Services
for ACADM

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ACADM Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor ACADM

Summariesfor ACADM

Genomic Locationfor ACADM

Proteinsfor ACADM

Protein Domains/Familiesfor ACADM

Gene Functionfor ACADM

Pathways & Interactionsfor ACADM

Drugs & Compoundsfor ACADM

Transcriptsfor ACADM

Expression for ACADM

Orthologsfor ACADM

Paralogsfor ACADM

SNPs/Variantsfor ACADM

Disorders & Mutationsfor ACADM

Medical Newsfor ACADM

Publicationsfor ACADM

Search for ACADM

Genome Databases showing ACADM

Other Databases showing ACADM

Specialized Databases showing ACADM

Licensable Technologiesfor ACADM

Servicesfor ACADM

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ACADM

Summaries
for ACADM

Genomic Location
for ACADM

Proteins
for ACADM

Protein Domains/
Families
for ACADM

Gene Function
for ACADM

Pathways & Interactions
for ACADM

Drugs & Compounds
for ACADM

Transcripts
for ACADM

Expression
for ACADM

Orthologs
for ACADM

Paralogs
for ACADM

SNPs/Variants
for ACADM

Disorders & Mutations
for ACADM

Medical News
for ACADM

Publications
for ACADM

Licensable Technologies
for ACADM

Services
for ACADM