Aliases for ACADM Gene
External Ids for ACADM Gene
Previous GeneCards Identifiers for ACADM Gene
This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ACADM Gene
ACADM (Acyl-CoA Dehydrogenase, C-4 To C-12 Straight Chain) is a Protein Coding gene. Diseases associated with ACADM include medium-chain acyl-coenzyme a dehydrogenase deficiency and acyl-coa dehydrogenase, medium chain, deficiency of. Among its related pathways are Metabolism and Carbon metabolism. GO annotations related to this gene include identical protein binding and oxidoreductase activity, acting on the CH-CH group of donors. An important paralog of this gene is ACAD8.
UniProtKB/Swiss-Prot for ACADM Gene
This enzyme is specific for acyl chain lengths of 4 to 16