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Aliases for ACAD11 Gene

Aliases for ACAD11 Gene

  • Acyl-CoA Dehydrogenase Family, Member 11 2 3
  • Acyl-Coenzyme A Dehydrogenase Family, Member 11 2 3
  • ACAD-11 3 4
  • Acyl-CoA Dehydrogenase Family Member 11 3
  • 62113 Protein 3
  • EC 1.3.99.- 4

External Ids for ACAD11 Gene

Previous GeneCards Identifiers for ACAD11 Gene

  • GC03M133761
  • GC03M132276
  • GC03M129656

Summaries for ACAD11 Gene

GeneCards Summary for ACAD11 Gene

ACAD11 (Acyl-CoA Dehydrogenase Family, Member 11) is a Protein Coding gene. Diseases associated with ACAD11 include childhood leukemia. GO annotations related to this gene include flavin adenine dinucleotide binding and long-chain-acyl-CoA dehydrogenase activity. An important paralog of this gene is ACAD8.

UniProtKB/Swiss-Prot for ACAD11 Gene

  • Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACAD11 Gene

Genomics for ACAD11 Gene

Regulatory Elements for ACAD11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ACAD11 Gene

Start:
132,558,138 bp from pter
End:
132,660,723 bp from pter
Size:
102,586 bases
Orientation:
Minus strand

Genomic View for ACAD11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACAD11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACAD11 Gene

Proteins for ACAD11 Gene

  • Protein details for ACAD11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q709F0-ACD11_HUMAN
    Recommended name:
    Acyl-CoA dehydrogenase family member 11
    Protein Accession:
    Q709F0
    Secondary Accessions:
    • Q08AF0
    • Q658N9
    • Q658Y2
    • Q6ZND2
    • Q8WUT6
    • Q9H9R3

    Protein attributes for ACAD11 Gene

    Size:
    780 amino acids
    Molecular mass:
    87283 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=BAB14158.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ACAD11 Gene

    Alternative splice isoforms for ACAD11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACAD11 Gene

Proteomics data for ACAD11 Gene at MOPED

Post-translational modifications for ACAD11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACAD11 Gene

Antibody Products

No data available for DME Specific Peptides for ACAD11 Gene

Domains for ACAD11 Gene

Suggested Antigen Peptide Sequences for ACAD11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q709F0

UniProtKB/Swiss-Prot:

ACD11_HUMAN :
  • Q709F0
Family:
  • Belongs to the acyl-CoA dehydrogenase family.
genes like me logo Genes that share domains with ACAD11: view

No data available for Gene Families for ACAD11 Gene

Function for ACAD11 Gene

Molecular function for ACAD11 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor
UniProtKB/Swiss-Prot Function: Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA.

Enzyme Numbers (IUBMB) for ACAD11 Gene

Gene Ontology (GO) - Molecular Function for ACAD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003995 acyl-CoA dehydrogenase activity --
GO:0004466 long-chain-acyl-CoA dehydrogenase activity IDA 21237683
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors --
GO:0016772 transferase activity, transferring phosphorus-containing groups IEA --
GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity IDA 21237683
genes like me logo Genes that share ontologies with ACAD11: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACAD11

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ACAD11 Gene

Localization for ACAD11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACAD11 Gene

Peroxisome. Mitochondrion. Note=Has been detected associated with mitochondrial membrane, but no matrix, in kidney and cerebellum, as well as in a neuroblastoma cell line, but not in skin fibroblasts, where it is observed in cytoplasmic vesicles (PubMed:21237683). No mitochondrial targeting signals could be predicted for any known isoform, including a putative isoform starting at Met-316. {ECO:0000269 PubMed:21237683}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACAD11 Gene COMPARTMENTS Subcellular localization image for ACAD11 gene
Compartment Confidence
mitochondrion 5
nucleus 5
peroxisome 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ACAD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21237683
GO:0005739 mitochondrion --
GO:0005777 peroxisome ISS --
GO:0031966 mitochondrial membrane IDA 21237683
genes like me logo Genes that share ontologies with ACAD11: view

Pathways for ACAD11 Gene

SuperPathways for ACAD11 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for ACAD11 Gene

Gene Ontology (GO) - Biological Process for ACAD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase IDA 21237683
GO:0055114 oxidation-reduction process --
genes like me logo Genes that share ontologies with ACAD11: view

No data available for Pathways by source for ACAD11 Gene

Compounds for ACAD11 Gene

(32) HMDB Compounds for ACAD11 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACAD11: view

Transcripts for ACAD11 Gene

Unigene Clusters for ACAD11 Gene

Acyl-CoA dehydrogenase family, member 11:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACAD11

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ACAD11
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACAD11 Gene

No ASD Table

Relevant External Links for ACAD11 Gene

GeneLoc Exon Structure for
ACAD11
ECgene alternative splicing isoforms for
ACAD11

Expression for ACAD11 Gene

mRNA expression in normal human tissues for ACAD11 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACAD11 Gene

SOURCE GeneReport for Unigene cluster for ACAD11 Gene Hs.441378

mRNA Expression by UniProt/SwissProt for ACAD11 Gene

Q709F0-ACD11_HUMAN
Tissue specificity: Widely expressed with highest levels in brain followed by liver, heart and kidney.
genes like me logo Genes that share expressions with ACAD11: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ACAD11 Gene

Orthologs for ACAD11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACAD11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACAD11 35
  • 99.62 (n)
  • 99.36 (a)
ACAD11 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACAD11 35
  • 88.33 (n)
  • 85 (a)
ACAD11 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACAD11 35
  • 88.25 (n)
  • 86.03 (a)
ACAD11 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acad11 35
  • 81.17 (n)
  • 81.09 (a)
Acad11 16
Acad11 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACAD11 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Acad11 35
  • 81.02 (n)
  • 81.19 (a)
chicken
(Gallus gallus)
Aves ACAD11 35
  • 71.73 (n)
  • 70.39 (a)
ACAD11 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACAD11 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acad11 35
  • 65.68 (n)
  • 67.14 (a)
zebrafish
(Danio rerio)
Actinopterygii acad11 35
  • 63.55 (n)
  • 64.82 (a)
acad11 36
  • 64 (a)
OneToOne
zgc55835 35
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL213W 35
  • 41.95 (n)
  • 32 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E15181g 35
  • 45.99 (n)
  • 31.41 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.25699 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01181 35
  • 53.5 (n)
  • 51.75 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11416 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for ACAD11:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for ACAD11 Gene

ENSEMBL:
Gene Tree for ACAD11 (if available)
TreeFam:
Gene Tree for ACAD11 (if available)

Paralogs for ACAD11 Gene

Paralogs for ACAD11 Gene

Selected SIMAP similar genes for ACAD11 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ACAD11: view

Variants for ACAD11 Gene

Sequence variations from dbSNP and Humsavar for ACAD11 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
VAR_028825 -
VAR_028826 -

Structural Variations from Database of Genomic Variants (DGV) for ACAD11 Gene

Variant ID Type Subtype PubMed ID
nsv829728 CNV Gain 17160897
esv2675190 CNV Deletion 23128226
esv2669271 CNV Deletion 23128226

Relevant External Links for ACAD11 Gene

HapMap Linkage Disequilibrium report
ACAD11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACAD11 Gene

Disorders for ACAD11 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ACAD11 Gene including...

Search for ACAD11 Gene in MalaCards »

Relevant External Links for ACAD11

Genetic Association Database (GAD)
ACAD11
Human Genome Epidemiology (HuGE) Navigator
ACAD11
genes like me logo Genes that share disorders with ACAD11: view

No data available for UniProtKB/Swiss-Prot for ACAD11 Gene

Publications for ACAD11 Gene

  1. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 48
  2. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3 48
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  4. Identification and characterization of new long chain acyl-CoA dehydrogenases. (PMID: 21237683) He M. … Vockley J. (Mol. Genet. Metab. 2011) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for ACAD11 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ACAD11
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ACAD11
    • Block miRNA regulation of ACAD11 using miScript Target Protectors

    Sources for ACAD11 Gene

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