Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACAD10 Gene

protein-coding   GIFtS: 53
GCID: GC12P112123

Acyl-CoA Dehydrogenase Family, Member 10

(Previous names: acyl-Coenzyme A dehydrogenase family, member 10)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Acyl-CoA Dehydrogenase Family, Member 101 2
Acyl-Coenzyme A Dehydrogenase Family, Member 101 2
ACAD-102 3
Acyl-CoA Dehydrogenase Family Member 102
EC 1.3.99.-3

External Ids:    HGNC: 215971   Entrez Gene: 807242   Ensembl: ENSG000001112717   OMIM: 6111815   UniProtKB: Q6JQN13   

Export aliases for ACAD10 gene to outside databases

Previous GC identifers: GC00U909456 GC12P110586 GC12P109137


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACAD10 Gene:
This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the
beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal
portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at
the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the
full-length nature of some of these variants has not been determined. (provided by RefSeq, Nov 2008)

GeneCards Summary for ACAD10 Gene: 
ACAD10 (acyl-CoA dehydrogenase family, member 10) is a protein-coding gene. Diseases associated with ACAD10 include sporadic breast cancer, and esophageal squamous cell carcinoma. GO annotations related to this gene include hydrolase activity and acyl-CoA dehydrogenase activity. An important paralog of this gene is ACADL.

UniProtKB/Swiss-Prot: ACD10_HUMAN, Q6JQN1
Function: Acyl-CoA dehydrogenase only active with R- and S-2-methyl-C15-CoA




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009775.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACAD10 gene promoter:
         HFH-3   FOXO3   FOXO3b   AREB6   FOXI1   MEF-2A   Nkx6-1   FOXO3a   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACAD10 promoter sequence
   Search SABiosciences Chromatin IP Primers for ACAD10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACAD10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.12   Ensembl cytogenetic band:  12q24.12   HGNC cytogenetic band: 12q24.12

ACAD10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACAD10 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P112123:  view genomic region     (about GC identifiers)

Start:
112,123,857 bp from pter      End:
112,194,911 bp from pter
Size:
71,055 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ACD10_HUMAN, Q6JQN1 (See protein sequence)
Recommended Name: Acyl-CoA dehydrogenase family member 10  
Size: 1059 amino acids; 118834 Da
Cofactor: FAD (By similarity)
Sequence caution: Sequence=AAH15056.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: G3XAJ0 Q8N828 Q8NAP2 Q96BX5
Alternative splicing: 5 isoforms:  Q6JQN1-1   Q6JQN1-2   Q6JQN1-3   Q6JQN1-4   Q6JQN1-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ACAD10: NX_Q6JQN1

Explore proteomics data for ACAD10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6JQN1

  • ACAD10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ACAD10 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001130010.1  NP_079523.3  

    ENSEMBL proteins: 
     ENSP00000421527   ENSP00000446959   ENSP00000389813   ENSP00000446998   ENSP00000449097  
     ENSP00000325137   ENSP00000447561   ENSP00000446711   ENSP00000376411  

    Human Recombinant Protein Products for ACAD10: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ACAD10
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ACAD10
    GenScript Custom Purified and Recombinant Proteins Services for ACAD10
    Novus Biologicals ACAD10 Protein
    Novus Biologicals ACAD10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ACAD10 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion NAS--

    ACAD10 for ontologies           About GeneDecksing



    ACAD10 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ACAD10
    GenScript Custom Superior Antibodies Services for ACAD10
    Novus Biologicals ACAD10 Antibodies
    Abcam antibodies for ACAD10
    Cloud-Clone Corp. Antibodies for ACAD10 
    ThermoFisher Antibody for ACAD10
    LSBio Antibodies in human, mouse, rat for ACAD10 

    Assay Products for ACAD10: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ACAD10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ACAD10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ACAD10 
    Cloud-Clone Corp. CLIAs for ACAD10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/13 InterPro protein domains (see all 13):
     IPR011945 HAD-SF_ppase_IA/epoxid_hydro_N
     IPR005833 Haloacid_DH/epoxide_hydro
     IPR006090 Acyl-CoA_Oxase/DH_1
     IPR009100 AcylCoA_DH/oxidase
     IPR013786 AcylCoA_DH/ox_N

    Graphical View of Domain Structure for InterPro Entry Q6JQN1

    ProtoNet protein and cluster: Q6JQN1

    1 Blocks protein domain: IPB002575 Aminoglycoside phosphotransferase

    UniProtKB/Swiss-Prot: ACD10_HUMAN, Q6JQN1
    Similarity: Belongs to the acyl-CoA dehydrogenase family


    ACAD10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACD10_HUMAN, Q6JQN1
    Function: Acyl-CoA dehydrogenase only active with R- and S-2-methyl-C15-CoA
    Catalytic activity: Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

         Enzyme Number (IUBMB): EC 1.3.99.-1

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003995acyl-CoA dehydrogenase activity IEA--
    GO:0016491oxidoreductase activity ----
    GO:0016627oxidoreductase activity, acting on the CH-CH group of donors ----
    GO:0016772transferase activity, transferring phosphorus-containing groups IEA--
    GO:0016787hydrolase activity IEA--
         
    ACAD10 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ACAD10 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ACAD10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACAD10 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACAD10 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACAD10
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate ACAD10:
    hsa-miR-188-3p hsa-miR-1184 hsa-miR-198 hsa-miR-3657
    SwitchGear 3'UTR luciferase reporter plasmidACAD10 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ACAD10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACAD10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ACAD10
    Sirion Biotech Customized adenovirus for overexpression of ACAD10

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ACAD10 (see all 12)
    OriGene ORF clones in mouse, rat for ACAD10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ACAD10 (NM_001136538)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACAD10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACAD10
    Sirion Biotech Customized lentivirus for stable overexpression of ACAD10 
                         Customized lentivirus expression plasmids for stable overexpression of ACAD10 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ACAD10
    Search LifeMap BioReagents cell lines for ACAD10
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACAD10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACAD10

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ACAD10 (ENSP000003898134) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELOF1ENSP000002524454STRING: ENSP00000252445
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----
    GO:0055114oxidation-reduction process ----

    ACAD10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACAD10 (ACD10)

    10/32 HMDB Compounds for ACAD10 (see all 32)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--

    Search CenterWatch for drugs/clinical trials and news about ACAD10 / ACD10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ACAD10 gene (3 alternative transcripts): 
    NM_001136538.1  NM_025247.5  NM_001136542.1  

    Unigene Cluster for ACAD10:

    Acyl-CoA dehydrogenase family, member 10
    Hs.331141  [show with all ESTs]
    Unigene Representative Sequence: NM_001136538
    18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000511915 ENST00000514615 ENST00000509936(uc009zvw.2) ENST00000413681(uc001tsp.3)
    ENST00000549590 ENST00000455480(uc009zvx.3 uc001tsq.3) ENST00000552965
    ENST00000507135(uc001tso.4) ENST00000515283 ENST00000313698 ENST00000502746
    ENST00000552706 ENST00000514847(uc001tsr.3) ENST00000507683 ENST00000503490
    ENST00000508303(uc001tss.1) ENST00000552177 ENST00000504803
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACAD10
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate ACAD10:
    hsa-miR-188-3p hsa-miR-1184 hsa-miR-198 hsa-miR-3657
    SwitchGear 3'UTR luciferase reporter plasmidACAD10 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ACAD10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACAD10
    Clone
    Products:
         
    OriGene clones in human, mouse for ACAD10 (see all 12)
    OriGene ORF clones in mouse, rat for ACAD10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ACAD10 (NM_001136538)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACAD10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACAD10
    Sirion Biotech Customized lentivirus for stable overexpression of ACAD10 
                         Customized lentivirus expression plasmids for stable overexpression of ACAD10 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ACAD10
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACAD10
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACAD10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACAD10

    Additional mRNA sequence: 

    AK021975.1 AK097425.1 AK310923.1 AL832043.1 AY323912.1 BC003698.1 BC015056.1 BC054886.1 
    BC126358.1 

    19 DOTS entries:

    DT.92041505  DT.121177783  DT.214370  DT.95365638  DT.75110858  DT.109315  DT.214373  DT.430137 
    DT.423114  DT.99984157  DT.121177752  DT.40127019  DT.91999544  DT.100782016  DT.121177772  DT.121177843 
    DT.95197534  DT.121177801  DT.95109293 

    24/651 AceView cDNA sequences (see all 651):

    BM772876 AI160133 AA419072 AI632626 AV650553 AA332335 BI491284 AA830815 
    BQ648302 AW473980 AI017596 BM784026 AA715095 AA677335 AA243179 AA923050 
    AI146792 BM664828 BM784372 BM853466 AV650270 AA341219 BM760986 BM919125 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for ACAD10 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^
    SP1:                          -                                               -     -                 -     -                       -                           
    SP2:                          -                       -                       -     -                 -     -                       -                           
    SP3:                          -                       -                       -     -                 -     -                       -                           
    SP4:                                                                                                  -     -     -     -           -                           
    SP5:                          -                       -                       -     -     -                                                                     

    ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b
    SP1:                    -           -     -               
    SP2:                    -                                 
    SP3:                    -           -     -               
    SP4:                    -                                 
    SP5:                                                      


    ECgene alternative splicing isoforms for ACAD10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACAD10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTCCCGAG
    ACAD10 Expression
    About this image


    See ACAD10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACAD10

    SOURCE GeneReport for Unigene cluster: Hs.331141

    UniProtKB/Swiss-Prot: ACD10_HUMAN, Q6JQN1
    Tissue specificity: Widely expressed with highest expression in fetal brain, followed by heart, muscle, kidney and
    adult brain. Expression levels varying from isoform to isoform

        SABiosciences Expression via Pathway-Focused PCR Array including ACAD10: 
              Fatty Acid Metabolism in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ACAD10
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACAD10
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACAD10
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACAD10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACAD10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACAD10 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acad101 , 5 acyl-Coenzyme A dehydrogenase family, member 101, 5 80.69(n)1
    80.25(a)1
      5 (61.88 cM)5
    719851  NM_028037.41  NP_082313.21 
     1216210265 
    chicken
    (Gallus gallus)
    Aves ACAD101 acyl-Coenzyme A dehydrogenase family, member 10 61.11(n)
    54.7(a)
      416879  XM_415170.2  XP_415170.2 
    lizard
    (Anolis carolinensis)
    Reptilia ACAD106
    Uncharacterized protein
    68(a)
    1 ↔ 1
    GL343282.1(780-16217)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD325578.12   -- 75.71(n)    CD325578.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_K09H11.11 Protein K09H11.1 50.43(n)
    46.85(a)
      178962  NM_072107.3  NP_504508.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons IBR31 acyl-CoA dehydrogenase 54.57(n)
    52.64(a)
      819865  NM_111561.4  NP_187337.2 
    rice
    (Oryza sativa)
    Liliopsida Os.271042 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.69(n)    AK073523.1 


    ENSEMBL Gene Tree for ACAD10 (if available)
    TreeFam Gene Tree for ACAD10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACAD10 gene
    ACADL2  ACAD82  ACADSB2  GCDH2  ACAD112  ACADS2  ACAD92  ACADM2  
    IVD2  ACADVL2  
    2 SIMAP similar genes for ACAD10 using alignment to 10 protein entries:     ACD10_HUMAN (see all proteins):
    ACAD11    EPHX2

    ACAD10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1412 SNPs in ACAD10 are shown (see all 1412)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1412996981,2
    C--112125920(+) CACTTA/CGGCCT 2 -- int10--------
    rs786230741,2
    C--112125962(+) CCGCGC/TCCGGC 2 -- int10--------
    rs6494061,2
    C,F,O,A,H--112126065(-) TTCCTA/GTGCCA 2 -- int124Minor allele frequency- G:0.45MN NS EA NA WA CSA 2532
    rs606947201,2
    C,F--112126271(+) CTATGT/CACACC 2 -- int12Minor allele frequency- C:0.09WA 120
    rs1853263261,2
    --112126377(+) GAGGCC/TGGTGG 2 -- int10--------
    rs1877565371,2
    C--112126554(+) TGAGCC/GGAGAT 2 -- int10--------
    rs1117343301,2
    C--112126568(+) ACCATC/TGCACT 2 -- int10--------
    rs2013392851,2
    --112126610(+) AAAAC-/AAAAAC 2 -- int10--------
    rs6088141,2
    C,F,A,H--112126615(-) tttttT/Gttttg 2 -- int15Minor allele frequency- G:0.22NA WA CSA 9
    rs589819141,2
    C--112126615(+) CAAAA-/CAAAAA 2 -- int10--------

    HapMap Linkage Disequilibrium report for ACAD10 (112123857 - 112194911 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ACAD10:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1492n71CNV Gain21882294


    Human Gene Mutation Database (HGMD): ACAD10
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ACAD10
    DNA2.0 Custom Variant and Variant Library Synthesis for ACAD10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611181    OMIM disorders: --

    7 diseases for ACAD10:    About MalaCards
    sporadic breast cancer    esophageal squamous cell carcinoma    insulin resistance    esophagitis
    squamous cell carcinoma    tuberculosis    breast cancer


    ACAD10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ACAD10
    Human Genome Epidemiology (HuGE) Navigator: ACAD10 (4 documents)

    Export disorders for ACAD10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACAD10 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with ACAD10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a human cDNA ACAD10 mapped to chromosome 12q24.1. (PubMed id 15560374)1, 2, 3 Ye X.... Mao Y. (2004)
    2. Variants in ACAD10 are associated with type 2 diabete s, insulin resistance and lipid oxidation in Pima Indians. (PubMed id 20390405)1, 4, 9 Bian L....Ma L. (2010)
    3. A meta-analysis and genome-wide association study of p latelet count and mean platelet volume in african americans. (PubMed id 22423221)1, 4 Qayyum R....Reiner A.P. (2012)
    4. Genome-wide association study identifies three new su sceptibility loci for esophageal squamous-cell carcinoma in Chinese populations . (PubMed id 21642993)1, 4 Wu C....Lin D. (2011)
    5. Identification and characterization of new long chain acyl-CoA dehydrogenases. (PubMed id 21237683)1, 2 He M....Vockley J. (2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    8. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (2009)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. A genome-wide association study of a coronary artery d isease risk variant. (PubMed id 23364394)1 Lee J.Y....Lee J.Y. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80724 HGNC: 21597 AceView: ALDH2andACAD10 Ensembl:ENSG00000111271 euGenes: HUgn80724
    ECgene: ACAD10 H-InvDB: ACAD10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACAD10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ACAD10 gene:
    Search GeneIP for patents involving ACAD10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ACAD10  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ACAD10  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ACAD10  
     OriGene qSTAR qPCR primer pairs in human, mouse for ACAD10   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ACAD10   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ACAD10   OriGene Custom Protein Services for ACAD10  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ACAD10
     QIAGEN SeqTarget long-range PCR primers for resequencing ACAD10
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACAD10
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACAD10
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACAD10
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACAD10
     GenScript Custom Purified and Recombinant Proteins Services for ACAD10 GenScript cDNA clones with any tag delivered in your preferred vector for ACAD10
     GenScript Custom Assay Services for ACAD10 GenScript Custom Superior Antibodies Services for ACAD10
     GenScript Custom overexpressing Cell Line Services for ACAD10 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ACAD10 promoter
     Search Chromatin IP Primers for ACAD10
     RT2 qPCR Primer Assay in human, mouse, rat ACAD10
     Search GNC Networks for ACAD10
     SABiosciences PCR Arrays including human, mouse, rat ACAD10
     Search Tocris compounds for ACAD10 (ACD10)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ACAD10 antibodies
     ACAD10 proteins
     ACAD10 lysates
     Antibodies for ACAD10
     See all of Abcam's Antibodies, Kits and Proteins for ACAD10
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ACAD10
     Antibodies for ACAD10
     ELISAs for ACAD10
     CLIAs for ACAD10
     Search LifeMap BioReagents cell lines for ACAD10
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACAD10
     SwitchGear 3'UTR luciferase reporter plasmids for ACAD10
     SwitchGear Promoter luciferase reporter plasmids for ACAD10
     ThermoFisher Antibody for ACAD10
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACAD10
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ACAD10
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ACAD10
    Customized:
     lentivirus for stable overexpression of ACAD10
     lentivirus expression plasmids for stable overexpression of ACAD10
     adenovirus for overexpression of ACAD10
     LSBio Antibodies in human, mouse, rat for ACAD10
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ACAD10 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4