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ACAD10 Gene

protein-coding   GIFtS: 53
GCID: GC12P112123

Acyl-CoA Dehydrogenase Family, Member 10

(Previous names: acyl-Coenzyme A dehydrogenase family, member 10)
  Search for ACAD10
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Acyl-CoA Dehydrogenase Family, Member 101 2
Acyl-Coenzyme A Dehydrogenase Family, Member 101 2
ACAD-102 3
Acyl-CoA Dehydrogenase Family Member 102
EC 1.3.99.-3

External Ids:    HGNC: 215971   Entrez Gene: 807242   Ensembl: ENSG000001112717   OMIM: 6111815   UniProtKB: Q6JQN13   

Export aliases for ACAD10 gene to outside databases

Previous GC identifers: GC00U909456 GC12P110586 GC12P109137


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ACAD10 Gene:
This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the
beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal
portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at
the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the
full-length nature of some of these variants has not been determined. (provided by RefSeq, Nov 2008)

GeneCards Summary for ACAD10 Gene:
ACAD10 (acyl-CoA dehydrogenase family, member 10) is a protein-coding gene. GO annotations related to this gene include hydrolase activity and acyl-CoA dehydrogenase activity. An important paralog of this gene is ACADL.

UniProtKB/Swiss-Prot: ACD10_HUMAN, Q6JQN1
Function: Acyl-CoA dehydrogenase only active with R- and S-2-methyl-C15-CoA




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACAD10 gene promoter:
         HFH-3   FOXO3   FOXO3b   AREB6   FOXI1   MEF-2A   Nkx6-1   FOXO3a   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACAD10 promoter sequence
   Search Chromatin IP Primers for ACAD10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACAD10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.12   Ensembl cytogenetic band:  12q24.12   HGNC cytogenetic band: 12q24.12

ACAD10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACAD10 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P112123:  view genomic region     (about GC identifiers)

Start:
112,123,857 bp from pter      End:
112,194,911 bp from pter
Size:
71,055 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ACD10_HUMAN, Q6JQN1 (See protein sequence)
Recommended Name: Acyl-CoA dehydrogenase family member 10  
Size: 1059 amino acids; 118834 Da
Cofactor: FAD (By similarity)
Sequence caution: Sequence=AAH15056.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: G3XAJ0 Q8N828 Q8NAP2 Q96BX5
Alternative splicing: 5 isoforms:  Q6JQN1-1   Q6JQN1-2   Q6JQN1-3   Q6JQN1-4   Q6JQN1-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ACAD10: NX_Q6JQN1

Explore proteomics data for ACAD10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys787
  • Modification sites at PhosphoSitePlus

  • See ACAD10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001130010.1  NP_079523.3  

    ENSEMBL proteins: 
     ENSP00000421527   ENSP00000446959   ENSP00000389813   ENSP00000446998   ENSP00000449097  
     ENSP00000325137   ENSP00000447561   ENSP00000446711   ENSP00000376411  

    ACAD10 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ACAD10
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    Novus Biologicals ACAD10 Protein
    Novus Biologicals ACAD10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ACAD10

     
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    ACAD10 Antibody Products:

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    Search eBioscience for ELISAs for ACAD10 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 10):
     IPR011945 HAD-SF_ppase_IA/epoxid_hydro_N
     IPR013786 AcylCoA_DH/ox_N
     IPR006091 Acyl-CoA_Oxase/DH_cen-dom
     IPR023214 HAD-like_dom
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q6JQN1

    ProtoNet protein and cluster: Q6JQN1

    1 Blocks protein domain: IPB002575 Aminoglycoside phosphotransferase

    UniProtKB/Swiss-Prot: ACD10_HUMAN, Q6JQN1
    Similarity: Belongs to the acyl-CoA dehydrogenase family


    Find genes that share domains with ACAD10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACD10_HUMAN, Q6JQN1
    Function: Acyl-CoA dehydrogenase only active with R- and S-2-methyl-C15-CoA
    Catalytic activity: Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

         Enzyme Number (IUBMB): EC 1.3.99.-1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003995acyl-CoA dehydrogenase activity IEA--
    GO:0016491oxidoreductase activity ----
    GO:0016627oxidoreductase activity, acting on the CH-CH group of donors ----
    GO:0016772transferase activity, transferring phosphorus-containing groups IEA--
    GO:0016787hydrolase activity IEA--
         
    Find genes that share ontologies with ACAD10           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACAD10
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    4 qRT-PCR Assays for microRNAs that regulate ACAD10:
    hsa-miR-188-3p hsa-miR-1184 hsa-miR-198 hsa-miR-3657
    SwitchGear 3'UTR luciferase reporter plasmidACAD10 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): ACAD10 (NM_001136538)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACAD10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACAD10

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion NAS--

    Find genes that share ontologies with ACAD10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including ACAD10: 
              Fatty Acid Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ACAD10

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for ACAD10 (ENSP000003898134) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BICD1ENSP000002814744STRING: ENSP00000281474
    BICD2ENSP000003493514STRING: ENSP00000349351
    ELOF1ENSP000002524454STRING: ENSP00000252445
    PISDENSP000002660954STRING: ENSP00000266095
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with ACAD10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACAD10 (ACD10)

    Selected HMDB Compounds for ACAD10 (see all 32)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ACAD10 gene (3 alternative transcripts): 
    NM_001136538.1  NM_025247.5  NM_001136542.1  

    Unigene Cluster for ACAD10:

    Acyl-CoA dehydrogenase family, member 10
    Hs.331141  [show with all ESTs]
    Unigene Representative Sequence: NM_001136538
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000511915 ENST00000514615 ENST00000509936(uc009zvw.2) ENST00000413681(uc001tsp.3)
    ENST00000549590 ENST00000455480(uc009zvx.3 uc001tsq.3) ENST00000552965
    ENST00000507135(uc001tso.4) ENST00000515283 ENST00000313698 ENST00000502746
    ENST00000552706 ENST00000514847(uc001tsr.3) ENST00000507683 ENST00000503490
    ENST00000508303(uc001tss.1) ENST00000552177 ENST00000504803
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate ACAD10:
    hsa-miR-188-3p hsa-miR-1184 hsa-miR-198 hsa-miR-3657
    SwitchGear 3'UTR luciferase reporter plasmidACAD10 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): ACAD10 (NM_001136538)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACAD10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACAD10
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACAD10
      QuantiTect SYBR Green Assays in human, mouse, rat ACAD10
      QuantiFast Probe-based Assays in human, mouse, rat ACAD10

    Additional mRNA sequence: 

    AK021975.1 AK097425.1 AK310923.1 AL832043.1 AY323912.1 BC003698.1 BC015056.1 BC054886.1 
    BC126358.1 

    19 DOTS entries:

    DT.92041505  DT.121177783  DT.214370  DT.95365638  DT.75110858  DT.109315  DT.214373  DT.430137 
    DT.423114  DT.99984157  DT.121177752  DT.40127019  DT.91999544  DT.100782016  DT.121177772  DT.121177843 
    DT.95197534  DT.121177801  DT.95109293 

    Selected AceView cDNA sequences (see all 651):

    AA677335 AA830815 BQ648302 K03001 AA995393 BI834562 AK097425 BM772876 
    BQ362166 BQ643713 AA316218 AI354279 BI771112 BE272838 BM765615 CD515435 
    BF725614 BU171977 R53433 CB997156 AW188884 CR609508 AI261830 BM784297 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ACAD10 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^
    SP1:                          -                                               -     -                 -     -                       -                           
    SP2:                          -                       -                       -     -                 -     -                       -                           
    SP3:                          -                       -                       -     -                 -     -                       -                           
    SP4:                                                                                                  -     -     -     -           -                           
    SP5:                          -                       -                       -     -     -                                                                     

    ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b
    SP1:                    -           -     -               
    SP2:                    -                                 
    SP3:                    -           -     -               
    SP4:                    -                                 
    SP5:                                                      


    ECgene alternative splicing isoforms for ACAD10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ACAD10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTCCCGAG
    ACAD10 Expression
    About this image

    ACAD10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACAD10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.331141

    UniProtKB/Swiss-Prot: ACD10_HUMAN, Q6JQN1
    Tissue specificity: Widely expressed with highest expression in fetal brain, followed by heart, muscle, kidney and
    adult brain. Expression levels varying from isoform to isoform

        Pathway & Disease-focused RT2 Profiler PCR Array including ACAD10: 
              Fatty Acid Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACAD10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACAD10 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acad101 , 5 acyl-Coenzyme A dehydrogenase family, member 101, 5 80.69(n)1
    80.25(a)1
      5 (61.88 cM)5
    719851  NM_028037.41  NP_082313.21 
     1216210265 
    lizard
    (Anolis carolinensis)
    Reptilia ACAD106
    acyl-CoA dehydrogenase family, member 10
    68(a)
    1 ↔ 1
    GL343282.1(780-16217)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD325578.12   -- 75.71(n)    CD325578.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_K09H11.11 CELE_K09H11.1 50.64(n)
    46.85(a)
      178962  NM_072107.4  NP_504508.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons IBR31 IBR3 54.42(n)
    52.03(a)
      819865  NM_111561.4  NP_187337.2 
    rice
    (Oryza sativa)
    Liliopsida Os.271042 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.69(n)    AK073523.1 


    ENSEMBL Gene Tree for ACAD10 (if available)
    TreeFam Gene Tree for ACAD10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ACAD10 gene
    ACADL2  ACADSB2  ACAD82  GCDH2  ACAD112  ACADS2  ACAD92  ACADM2  
    IVD2  ACADVL2  
    1 SIMAP similar gene for ACAD10 using alignment to 7 protein entries:     ACD10_HUMAN (see all proteins):
    ACAD11

    Find genes that share paralogs with ACAD10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ACAD10 (see all 1412)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1412996981,2
    C--112125920(+) CACTTA/CGGCCT 2 -- int10--------
    rs786230741,2
    C--112125962(+) CCGCGC/TCCGGC 2 -- int10--------
    rs6494061,2
    C,F,O,A,H--112126065(-) TTCCTA/GTGCCA 2 -- int124Minor allele frequency- G:0.45MN NS EA NA WA CSA 2532
    rs606947201,2
    C,F--112126271(+) CTATGT/CACACC 2 -- int12Minor allele frequency- C:0.09WA 120
    rs1853263261,2
    --112126377(+) GAGGCC/TGGTGG 2 -- int10--------
    rs1877565371,2
    C--112126554(+) TGAGCC/GGAGAT 2 -- int10--------
    rs1117343301,2
    C--112126568(+) ACCATC/TGCACT 2 -- int10--------
    rs2013392851,2
    --112126610(+) AAAAC-/AAAAAC 2 -- int10--------
    rs6088141,2
    C,F,A,H--112126615(-) tttttT/Gttttg 2 -- int15Minor allele frequency- G:0.22NA WA CSA 9
    rs589819141,2
    C--112126615(+) CAAAA-/CAAAAA 2 -- int10--------

    HapMap Linkage Disequilibrium report for ACAD10 (112123857 - 112194911 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ACAD10:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1492n71CNV Gain21882294

    Human Gene Mutation Database (HGMD): ACAD10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ACAD10
    DNA2.0 Custom Variant and Variant Library Synthesis for ACAD10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611181    OMIM disorders: --


    Find genes that share disorders with ACAD10           About GenesLikeMe

    Genetic Association Database (GAD): ACAD10
    Human Genome Epidemiology (HuGE) Navigator: ACAD10 (4 documents)

    Export disorders for ACAD10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ACAD10 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with ACAD10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a human cDNA ACAD10 mapped to chromosome 12q24.1. (PubMed id 15560374)1, 2, 3 Ye X.... Mao Y. (Mol. Biol. Rep. 2004)
    2. Variants in ACAD10 are associated with type 2 diabetes, insulin resistance and lipid oxidation in Pima Indians. (PubMed id 20390405)1, 4, 9 Bian L....Baier L.J. (Diabetologia 2010)
    3. A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans. (PubMed id 22423221)1, 4 Qayyum R....Reiner A.P. (PLoS Genet. 2012)
    4. Identification and characterization of new long chain acyl-CoA dehydrogenases. (PubMed id 21237683)1, 2 He M.... Vockley J. (Mol. Genet. Metab. 2011)
    5. Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. (PubMed id 21642993)1, 4 Wu C....Lin D. (Nat. Genet. 2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    8. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. A genome-wide association study of a coronary artery disease risk variant. (PubMed id 23364394)1 Lee J.Y....Lee J.Y. (J. Hum. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80724 HGNC: 21597 AceView: ALDH2andACAD10 Ensembl:ENSG00000111271 euGenes: HUgn80724
    ECgene: ACAD10 H-InvDB: ACAD10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ACAD10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ACAD10 gene:
    Search GeneIP for patents involving ACAD10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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