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ACAD10 Gene(Protein Coding)

Acyl-CoA Dehydrogenase Family Member 10

GCID:
GC12P111686
GIFtS:
51
Genes Participants
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Aliases for ACAD10 Gene

Aliases for ACAD10 Gene

  • Acyl-CoA Dehydrogenase Family Member 10 2 3 5
  • Acyl-Coenzyme A Dehydrogenase Family, Member 10 2 3
  • ACAD-10 3 4
  • Acyl-CoA Dehydrogenase Family, Member 10 2
  • EC 1.3.99.- 4

External Ids for ACAD10 Gene

Previous GeneCards Identifiers for ACAD10 Gene

  • GC00U909456
  • GC12P110586
  • GC12P112123
  • GC12P109137

Summaries for ACAD10 Gene

Entrez Gene Summary for ACAD10 Gene

  • This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Nov 2008]

GeneCards Summary for ACAD10 Gene

ACAD10 (Acyl-CoA Dehydrogenase Family Member 10) is a Protein Coding gene. Among its related pathways are Mitochondrial Fatty Acid Beta-Oxidation and Metabolism. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and flavin adenine dinucleotide binding. An important paralog of this gene is ACAD11.

UniProtKB/Swiss-Prot for ACAD10 Gene

  • Acyl-CoA dehydrogenase only active with R- and S-2-methyl-C15-CoA.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACAD10 Gene

Genomics for ACAD10 Gene

Products:

  1. Regulatory Element

Regulatory Elements for ACAD10 Gene

Enhancers for ACAD10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G111772 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +89.7 89692 6.2 HDGF PKNOX1 FOXA2 ARNT ARID4B DMAP1 YY1 SLC30A9 ZNF766 SP5 ALDH2 ACAD10 BRAP SH2B3 FAM109A GC12P111792
GH12G111788 1.1 ENCODE dbSUPER 11.3 +102.5 102503 0.6 ZSCAN4 ARID4B ZNF48 RAD21 YY1 ZNF121 SCRT2 ZNF143 ZNF654 CEBPB ADAM1A ALDH2 ACAD10 BRAP GC12P111792
GH12G111813 1.1 Ensembl ENCODE 10.9 +127.2 127248 0.6 PKNOX1 CBX3 ARID4B FEZF1 ZNF2 ZNF48 RAD21 SCRT2 ZNF143 CREM ALDH2 ACAD10 BRAP GC12P111809 GC12P111836
GH12G111787 1 ENCODE dbSUPER 11.3 +101.5 101489 0.1 ELF3 SOX13 TFAP4 MXI1 FOXA2 SAP130 ARID4B MAX RAD21 ZNF644 ALDH2 ACAD10 BRAP GC12P111792
GH12G111780 0.8 ENCODE dbSUPER 10.8 +94.9 94895 1.7 CTCF ZNF280D FOS ZNF623 YY1 ACAD10 BRAP GC12P111792 ALDH2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ACAD10 on UCSC Golden Path with GeneCards custom track

Promoters for ACAD10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000057462 -153 1801 HNRNPUL1 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 FEZF1

Transcription factor binding sites by QIAGEN in the ACAD10 gene promoter:

Genomic Location for ACAD10 Gene

Chromosome:
12
Start:
111,686,053 bp from pter
End:
111,757,107 bp from pter
Size:
71,055 bases
Orientation:
Plus strand

Genomic View for ACAD10 Gene

Genes around ACAD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACAD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACAD10 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ACAD10 Gene

Proteins for ACAD10 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ACAD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6JQN1-ACD10_HUMAN
    Recommended name:
    Acyl-CoA dehydrogenase family member 10
    Protein Accession:
    Q6JQN1
    Secondary Accessions:
    • G3XAJ0
    • Q8N828
    • Q8NAP2
    • Q96BX5

    Protein attributes for ACAD10 Gene

    Size:
    1059 amino acids
    Molecular mass:
    118834 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH15056.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ACAD10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACAD10 Gene

Protein Expression for ACAD10 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ACAD10 Gene

  • Ubiquitination at posLast=787787
  • Modification sites at PhosphoSitePlus

Other Protein References for ACAD10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ACAD10

No data available for DME Specific Peptides for ACAD10 Gene

Domains & Families for ACAD10 Gene

Gene Families for ACAD10 Gene

HGNC:

Protein Domains for ACAD10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ACAD10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6JQN1

UniProtKB/Swiss-Prot:

ACD10_HUMAN :
  • Belongs to the acyl-CoA dehydrogenase family.
Family:
  • Belongs to the acyl-CoA dehydrogenase family.
genes like me logo Genes that share domains with ACAD10: view

Function for ACAD10 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for ACAD10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.
UniProtKB/Swiss-Prot Function:
Acyl-CoA dehydrogenase only active with R- and S-2-methyl-C15-CoA.

Enzyme Numbers (IUBMB) for ACAD10 Gene

Gene Ontology (GO) - Molecular Function for ACAD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003995 acyl-CoA dehydrogenase activity TAS --
GO:0016491 oxidoreductase activity IEA --
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IEA --
GO:0016787 hydrolase activity IEA --
GO:0050660 flavin adenine dinucleotide binding IEA --
genes like me logo Genes that share ontologies with ACAD10: view
genes like me logo Genes that share phenotypes with ACAD10: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ACAD10

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACAD10 Gene

Localization for ACAD10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACAD10 gene
Compartment Confidence
mitochondrion 5
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ACAD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion NAS 21237683
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with ACAD10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ACAD10 Gene

Pathways & Interactions for ACAD10 Gene

genes like me logo Genes that share pathways with ACAD10: view

Gene Ontology (GO) - Biological Process for ACAD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006635 fatty acid beta-oxidation TAS --
GO:0008152 metabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ACAD10: view

No data available for SIGNOR curated interactions for ACAD10 Gene

Drugs & Compounds for ACAD10 Gene

Products:

  1. Drug

(1) Drugs for ACAD10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propionyl-CoA Experimental Pharma 0

(31) Additional Compounds for ACAD10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
 10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
 1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
 4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
 10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
 38795-33-4
genes like me logo Genes that share compounds with ACAD10: view

Transcripts for ACAD10 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for ACAD10 Gene

(3) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(651) Selected AceView cDNA sequences:
(24) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACAD10 Gene

Acyl-CoA dehydrogenase family, member 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACAD10 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - -
SP8: - -
SP9: - -
SP10: - -
SP11: - - - - - - - - - - - - - - - - - - - - - -
SP12:
SP13:
SP14:

ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b
SP1: - - -
SP2: -
SP3: - - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:

Relevant External Links for ACAD10 Gene

GeneLoc Exon Structure for
ACAD10
ECgene alternative splicing isoforms for
ACAD10

Expression for ACAD10 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACAD10 Gene

mRNA expression in normal human tissues for ACAD10 Gene
mRNA expression by BioGPS for ACAD10 GenemRNA expression by GTEx for ACAD10 Gene

Protein differential expression in normal tissues from HIPED for ACAD10 Gene

This gene is overexpressed in Breast (14.6), Bone (13.1), and Pancreas (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ACAD10 Gene



Protein tissue co-expression partners for ACAD10 Gene

NURSA nuclear receptor signaling pathways regulating expression of ACAD10 Gene:

ACAD10

SOURCE GeneReport for Unigene cluster for ACAD10 Gene:

Hs.331141

mRNA Expression by UniProt/SwissProt for ACAD10 Gene:

Q6JQN1-ACD10_HUMAN
Tissue specificity: Widely expressed with highest expression in fetal brain, followed by heart, muscle, kidney and adult brain. Expression levels varying from isoform to isoform.

Evidence on tissue expression from TISSUES for ACAD10 Gene

  • Nervous system(4.5)
  • Liver(4.2)
  • Skin(4.2)
  • Bone marrow(4.1)
genes like me logo Genes that share expression patterns with ACAD10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACAD10 Gene

Orthologs for ACAD10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACAD10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ACAD10 34 35
  • 99.3 (n)
cow
(Bos Taurus)
 Mammalia ACAD10 34 35
  • 86.1 (n)
dog
(Canis familiaris)
 Mammalia ACAD10 34 35
  • 83.55 (n)
mouse
(Mus musculus)
 Mammalia Acad10 34 16 35
  • 80.69 (n)
Acad12 35
  • 73 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia ACAD10 35
  • 65 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia ACAD10 35
  • 64 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia ACAD10 35
  • 68 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia acad10 34
  • 64.56 (n)
worm
(Caenorhabditis elegans)
 Secernentea CELE_K09H11.1 34
  • 50.64 (n)
K09H11.1 35
  • 45 (a)
 OneToOne
thale cress
(Arabidopsis thaliana)
 eudicotyledons IBR3 34
  • 54.42 (n)
rice
(Oryza sativa)
 Liliopsida Os07g0675000 34
  • 54.27 (n)
Os.27104 34
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.4955 35
  • 55 (a)
 OneToOne
Species where no ortholog for ACAD10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ACAD10 Gene

ENSEMBL:
Gene Tree for ACAD10 (if available)
TreeFam:
Gene Tree for ACAD10 (if available)

Paralogs for ACAD10 Gene

Paralogs for ACAD10 Gene

(1) SIMAP similar genes for ACAD10 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ACAD10: view

Variants for ACAD10 Gene

Sequence variations from dbSNP and Humsavar for ACAD10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000155858 -- 111,720,439(+) TTTGA(C/T)CATTT intron-variant
rs1000171252 -- 111,701,764(+) CCTAT(A/G)GAAGG intron-variant
rs1000180116 -- 111,747,280(+) GGAAT(A/G)TGCTC intron-variant
rs1000232280 -- 111,747,114(+) GAAGC(A/G)CAGAA reference, synonymous-codon
rs1000268463 -- 111,693,886(+) TGGGG(C/G)ACTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACAD10 Gene

Variant ID Type Subtype PubMed ID
dgv1556n100 CNV gain 25217958
dgv2874n54 CNV gain 21841781
dgv304e214 CNV gain 21293372
dgv514e212 CNV gain 25503493
esv2760710 CNV gain 21179565
esv3581893 CNV gain 25503493
esv3630762 CNV gain 21293372
esv3630763 CNV gain 21293372
nsv1119985 CNV deletion 24896259

Variation tolerance for ACAD10 Gene

Residual Variation Intolerance Score: 71.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.00; 74.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACAD10 Gene

Human Gene Mutation Database (HGMD)
ACAD10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACAD10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACAD10 Gene

Disorders for ACAD10 Gene

Relevant External Links for ACAD10

Genetic Association Database (GAD)
ACAD10
Human Genome Epidemiology (HuGE) Navigator
ACAD10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACAD10

No disorders were found for ACAD10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACAD10 Gene

Publications for ACAD10 Gene

  1. Variants in ACAD10 are associated with type 2 diabetes, insulin resistance and lipid oxidation in Pima Indians. (PMID: 20390405) Bian L. … Baier L.J. (Diabetologia 2010) 3 22 46 64
  2. Cloning and characterization of a human cDNA ACAD10 mapped to chromosome 12q24.1. (PMID: 15560374) Ye X. … Mao Y. (Mol. Biol. Rep. 2004) 2 3 4 64
  3. A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans. (PMID: 22423221) Qayyum R. … Reiner A.P. (PLoS Genet. 2012) 3 46 64
  4. Identification and characterization of new long chain acyl-CoA dehydrogenases. (PMID: 21237683) He M. … Vockley J. (Mol. Genet. Metab. 2011) 3 4 64
  5. Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. (PMID: 21642993) Wu C. … Lin D. (Nat. Genet. 2011) 3 46 64

Products for ACAD10 Gene

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