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Aliases for ACAD10 Gene

Aliases for ACAD10 Gene

  • Acyl-CoA Dehydrogenase Family Member 10 2 3 5
  • Acyl-Coenzyme A Dehydrogenase Family, Member 10 2 3
  • Acyl-CoA Dehydrogenase Family, Member 10 2 3
  • ACAD-10 3 4
  • EC 1.3.99.- 4

External Ids for ACAD10 Gene

Previous GeneCards Identifiers for ACAD10 Gene

  • GC00U909456
  • GC12P110586
  • GC12P112123
  • GC12P109137

Summaries for ACAD10 Gene

Entrez Gene Summary for ACAD10 Gene

  • This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Nov 2008]

GeneCards Summary for ACAD10 Gene

ACAD10 (Acyl-CoA Dehydrogenase Family Member 10) is a Protein Coding gene. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and flavin adenine dinucleotide binding. An important paralog of this gene is ACAD8.

UniProtKB/Swiss-Prot for ACAD10 Gene

  • Acyl-CoA dehydrogenase only active with R- and S-2-methyl-C15-CoA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACAD10 Gene

Genomics for ACAD10 Gene

Regulatory Elements for ACAD10 Gene

Promoters for ACAD10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ACAD10 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACAD10 Gene

Chromosome:
12
Start:
111,686,053 bp from pter
End:
111,757,107 bp from pter
Size:
71,055 bases
Orientation:
Plus strand

Genomic View for ACAD10 Gene

Genes around ACAD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACAD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACAD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACAD10 Gene

Proteins for ACAD10 Gene

  • Protein details for ACAD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6JQN1-ACD10_HUMAN
    Recommended name:
    Acyl-CoA dehydrogenase family member 10
    Protein Accession:
    Q6JQN1
    Secondary Accessions:
    • G3XAJ0
    • Q8N828
    • Q8NAP2
    • Q96BX5

    Protein attributes for ACAD10 Gene

    Size:
    1059 amino acids
    Molecular mass:
    118834 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH15056.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ACAD10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACAD10 Gene

Proteomics data for ACAD10 Gene at MOPED

Post-translational modifications for ACAD10 Gene

  • Ubiquitination at Lys 787
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ACAD10 Gene

Domains & Families for ACAD10 Gene

Gene Families for ACAD10 Gene

Suggested Antigen Peptide Sequences for ACAD10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6JQN1

UniProtKB/Swiss-Prot:

ACD10_HUMAN :
  • Belongs to the acyl-CoA dehydrogenase family.
Family:
  • Belongs to the acyl-CoA dehydrogenase family.
genes like me logo Genes that share domains with ACAD10: view

Function for ACAD10 Gene

Molecular function for ACAD10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.
UniProtKB/Swiss-Prot Function:
Acyl-CoA dehydrogenase only active with R- and S-2-methyl-C15-CoA.

Enzyme Numbers (IUBMB) for ACAD10 Gene

Gene Ontology (GO) - Molecular Function for ACAD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000062 fatty-acyl-CoA binding IBA --
GO:0009055 electron carrier activity IBA --
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IEA --
GO:0016787 hydrolase activity IEA --
GO:0050660 flavin adenine dinucleotide binding IEA,IBA --
genes like me logo Genes that share ontologies with ACAD10: view

Phenotypes for ACAD10 Gene

genes like me logo Genes that share phenotypes with ACAD10: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACAD10 Gene

Localization for ACAD10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACAD10 Gene COMPARTMENTS Subcellular localization image for ACAD10 gene
Compartment Confidence
mitochondrion 5
cytosol 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ACAD10 Gene

Pathways & Interactions for ACAD10 Gene

genes like me logo Genes that share pathways with ACAD10: view

Interacting Proteins for ACAD10 Gene

Gene Ontology (GO) - Biological Process for ACAD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ACAD10: view

No data available for SIGNOR curated interactions for ACAD10 Gene

Drugs & Compounds for ACAD10 Gene

(1) Drugs for ACAD10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propionyl-CoA Experimental Pharma 0

(31) Additional Compounds for ACAD10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACAD10: view

Transcripts for ACAD10 Gene

Unigene Clusters for ACAD10 Gene

Acyl-CoA dehydrogenase family, member 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACAD10 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - -
SP8: - -
SP9: - -
SP10: - -
SP11: - - - - - - - - - - - - - - - - - - - - - -
SP12:
SP13:
SP14:

ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b
SP1: - - -
SP2: -
SP3: - - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:

Relevant External Links for ACAD10 Gene

GeneLoc Exon Structure for
ACAD10
ECgene alternative splicing isoforms for
ACAD10

Expression for ACAD10 Gene

mRNA expression in normal human tissues for ACAD10 Gene

Protein differential expression in normal tissues from HIPED for ACAD10 Gene

This gene is overexpressed in Breast (14.6), Bone (13.1), and Pancreas (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ACAD10 Gene



SOURCE GeneReport for Unigene cluster for ACAD10 Gene Hs.331141

mRNA Expression by UniProt/SwissProt for ACAD10 Gene

Q6JQN1-ACD10_HUMAN
Tissue specificity: Widely expressed with highest expression in fetal brain, followed by heart, muscle, kidney and adult brain. Expression levels varying from isoform to isoform.
genes like me logo Genes that share expression patterns with ACAD10: view

Protein tissue co-expression partners for ACAD10 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ACAD10 Gene

Orthologs for ACAD10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACAD10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACAD10 35
  • 86.1 (n)
  • 85.47 (a)
ACAD10 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACAD10 35
  • 83.55 (n)
  • 78.25 (a)
ACAD10 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acad10 35
  • 80.69 (n)
  • 80.25 (a)
Acad10 16
Acad10 36
  • 79 (a)
OneToMany
Acad12 36
  • 73 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ACAD10 35
  • 99.3 (n)
  • 99.27 (a)
ACAD10 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACAD10 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACAD10 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACAD10 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acad10 35
  • 64.56 (n)
  • 66.32 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_K09H11.1 35
  • 50.64 (n)
  • 46.85 (a)
K09H11.1 36
  • 45 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons IBR3 35
  • 54.42 (n)
  • 52.03 (a)
rice
(Oryza sativa)
Liliopsida Os.27104 35
Os07g0675000 35
  • 54.27 (n)
  • 52.31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4955 36
  • 55 (a)
OneToOne
Species with no ortholog for ACAD10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ACAD10 Gene

ENSEMBL:
Gene Tree for ACAD10 (if available)
TreeFam:
Gene Tree for ACAD10 (if available)

Paralogs for ACAD10 Gene

Paralogs for ACAD10 Gene

(1) SIMAP similar genes for ACAD10 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ACAD10: view

Variants for ACAD10 Gene

Sequence variations from dbSNP and Humsavar for ACAD10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs35276160 - 111,709,593(+) GGAGC(A/G)GCTCG reference, missense
rs35753710 - 111,709,640(+) TTGGA(A/C)CAAAT reference, missense
rs36046440 - 111,729,949(+) ACGGG(A/G)ACTTC reference, missense
rs34245489 - 111,748,470(+) AGATG(C/T)ACCAG reference, missense
rs14630 -- 111,756,744(+) GGCTC(C/T)CAGTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ACAD10 Gene

Variant ID Type Subtype PubMed ID
dgv1492n71 CNV Gain 21882294

Variation tolerance for ACAD10 Gene

Residual Variation Intolerance Score: 71.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.00; 74.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACAD10 Gene

HapMap Linkage Disequilibrium report
ACAD10
Human Gene Mutation Database (HGMD)
ACAD10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACAD10 Gene

Disorders for ACAD10 Gene

Relevant External Links for ACAD10

Genetic Association Database (GAD)
ACAD10
Human Genome Epidemiology (HuGE) Navigator
ACAD10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACAD10

No disorders were found for ACAD10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACAD10 Gene

Publications for ACAD10 Gene

  1. Cloning and characterization of a human cDNA ACAD10 mapped to chromosome 12q24.1. (PMID: 15560374) Ye X. … Mao Y. (Mol. Biol. Rep. 2004) 2 3 4 67
  2. Variants in ACAD10 are associated with type 2 diabetes, insulin resistance and lipid oxidation in Pima Indians. (PMID: 20390405) Bian L. … Baier L.J. (Diabetologia 2010) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A genome-wide association study of a coronary artery disease risk variant. (PMID: 23364394) Lee J.Y. … Lee J.Y. (J. Hum. Genet. 2013) 3

Products for ACAD10 Gene

Sources for ACAD10 Gene

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