Services
Jump to Section...
Aliases for ACACA
Databases for ACACA
Disorders for ACACA
Domains/Families for ACACA
Drugs/Compounds for ACACA
Expression for ACACA
Function for ACACA
Location for ACACA
Medical News for ACACA
Orthologs for ACACA
Paralogs for ACACA
Pathways/Interactions for ACACA
Proteins for ACACA
Publications for ACACA
SNPs for ACACA
Search Box for ACACA
Services for ACACA
Summaries for ACACA
Technologies for ACACA
Transcripts for ACACA
TOP
BOTTOM
Aliases & Descriptions for ACACA
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Aliases ACAC 2 , 3 , 5 ACC 2 ACC-alpha 2 , 3 ACC1 1 , 2 , 3 , 5 ACCA 2 , 3 EC 6.4.1.2 3 OTTHUMP00000164069 2
Descriptions acetyl-CoA carboxylase 1 2 acetyl-CoA carboxylase-alpha 2 acetyl-Coenzyme A carboxylase alpha 2
Search outside databases for aliases for ACACA genePrevious GC identifers: GC17M034828 GC17M037396 GC17M035173 GC17M035639 GC17M035637
Summaries for ACACA (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
EntrezGene summary for ACACA : Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containingenzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step infatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes.ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at thetranscriptional and translational levels and under short term regulation by thephosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation bycitrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the5' sequence and encoding distinct isoforms have been found for this gene. [provided byRefSeq] UniProtKB/Swiss-Prot: ACACA_HUMAN, Q13085 Function : Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carriesout three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase
Genomic Location for ACACA
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the ACACA gene Entrez Gene cytogenetic band: 17q21 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q21 ACACA Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17M032516:
(about GC identifiers )
Start:
32,516,036 bp from pter
End:
32,841,015 bp from pter
Size:
324,980 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000017.9 NT_078100.1 Proteins for ACACA
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
UniProtKB/Swiss-Prot: ACACA_HUMAN, Q13085 (See
protein sequence )Recommended Name: Acetyl-CoA carboxylase 1 Size : 2346 amino acids; 265554 Da
Cofactor : Biotin
Cofactor : Binds 2 manganese ions per subunit
Subunit : Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 whichprevents ACACA dephosphorylation and inhibits lipid synthesis
Subcellular location : Cytoplasm
Secondary accessions : B2RP68 Q6KEV6 Q6XDA8 Q7Z2G8 Q7Z561 Q7Z563 Q7Z564 Q86WB2 Q86WB3Alternative promoter usage : 4 isoforms : Q13085-1 Q13085-2 Q13085-3 Q13085-4
Post-translational modifications:
Phosphorylation on Ser-1263 is required for interaction with BRCA11
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (5 alternative transcripts):
NP_942131.1 NP_942133.1 NP_942134.1 NP_942135.1 NP_942136.1 ENSEMBL proteins: ENSP00000377925 ENSP00000335323 ENSP00000377928 ENSP00000354565 ENSP00000353898 ENSP00000377929 ENSP00000344789 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 1 Gene Ontology (GO) cellular component term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005737 cytoplasm
IEA --
About this table Antibodies for ACACA: Assays for ACACA:
Protein
Domains/ Families for ACACA(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Graphical View of Domain Structure for InterPro Entry Q13085 ProtoNet protein and cluster: Q13085
2 Blocks protein families : IPB001882 Biotin-requiring enzyme IPB013537 Acetyl-CoA carboxylase UniProtKB/Swiss-Prot: ACACA_HUMAN, Q13085 Similarity : Contains 1 ATP-grasp domainSimilarity : Contains 1 biotin carboxylation domainSimilarity : Contains 1 biotinyl-binding domainSimilarity : Contains 1 carboxyltransferase domain
Gene Function for ACACA
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6 ): NM_000664 Applied Biosystems Silencer ® siRNAs for ACACA Sigma-Aldrich siRNA and siRNA Panels for ACACA Sigma-Aldrich shRNA for ACACA Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 5 ): NM_198834                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 5 ): NM_198834                                  untagged cDNA clones in CMV expression vector (see all 5 ): NM_198834  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_198834 UniProtKB/Swiss-Prot: ACACA_HUMAN, Q13085 Function : Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carriesout three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase Catalytic activity : ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoACatalytic activity : ATP + biotin-carboxyl-carrier protein + CO(2) = ADP + phosphate +carboxybiotin-carboxyl-carrier protein Enzyme regulation : By phosphorylation (By similarity)Enzyme Number (IUBMB): EC 6.4.1.2
Genatlas biochemistry entry for ACACA :acetyl-CoA carboxylase alpha,265kDa,biotine dependent,expressed in lipogenictissues,cytosolic,catalyzing the synthesis of malonyl-CoA,an intermediate substrate playing apivotal role in the regulation of fatty acid metabolism
5 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Acaca) :5/9 Gene Ontology (GO) molecular function terms (links to tree view) (see all 9
):
About this table
Pathways & Interactions for ACACA
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
5 Sigma-Aldrich "Your Favorite Gene" Pathways for ACACA (Your Favorite Gene powered by Ingenuity) UniProtKB/Swiss-Prot: ACACA_HUMAN, Q13085 Pathway : Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1
Gene Network CentralTM Interacting Genes and Proteins Network for ACACA 5/35 Interacting proteins for ACACA (ENSP00000344789 3 Q13085 1 , 2 ) via UniProtKB, MINT, and/or STRING (see all 35
)About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006633 fatty acid biosynthetic process
IEA -- GO:0008152 metabolic process
IEA --
About this table
Drugs & Compounds for ACACA (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Enzo Life Sciences drugs & compounds for ACACA
Browse Tocris compounds for ACACA 10/24 Novoseek chemical compound relationships for ACACA gene (see all 24
)
Compound
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
acetyl-coa
95.94
185
19236960 (2), 12810950 (2), 15333468 (2), 16707454 (2) (see all 99 )
malonyl-coa
83.29
14
10212840 (2), 18614968 (1), 12392882 (1), 11420304 (1) (see all 7 )
fatty acid
82.73
171
17173081 (6), 7937924 (3), 15749055 (3), 18056116 (3) (see all 83 )
sterol
72.88
16
19054139 (1), 15648028 (1), 12897191 (1), 17577393 (1) (see all 11 )
acadesine
66.44
3
9781330 (1), 11423479 (1), 17173081 (1)
glycerol 3-phosphate
60.03
5
16864897 (1), 17762189 (1), 12759350 (1), 15810992 (1) (see all 5 )
3-hydroxy-3-methylglutaryl-coa
53.33
2
19036562 (1)
lipid
52.87
29
1349893 (4), 15371448 (2), 18482975 (1), 19100718 (1) (see all 16 )
triacylglycerol
51.23
3
16864897 (2), 16873691 (1)
glucose
50.96
77
7490534 (11), 17173081 (6), 8103051 (5), 12759350 (4) (see all 21 )
About this table
Transcripts for ACACA(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
OriGene , Expression Assays from Applied Biosystems )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6 ): NM_000664 Sigma-Aldrich siRNA and siRNA Panels for ACACA Sigma-Aldrich shRNA for ACACA Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_198834 NM_198836 NM_198837 NM_198838 NM_198839
REFSEQ mRNAs for ACACA gene (5 alternative transcripts): NM_198834.1 NM_198836.1 NM_198837.1 NM_198838.1 NM_198839.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_198834 NM_198836 NM_198837 NM_198838 NM_198839
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 5 ): NM_198834                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 5 ): NM_198834                                  untagged cDNA clones in CMV expression vector (see all 5 ): NM_198834  
Additional cDNA sequence: AB209325.1 AB371587.1 AJ534888.1 AJ534889.1 AJ564444.1 AK129523.1 AK295586.1 AK295735.1 AK295805.1 AK296368.1 AK301579.1 AK308905.1 AK309084.1 AK309424.1 AK311329.1 AY237919.1 AY315619.1 AY315620.1 AY315621.1 AY315622.1 AY315623.1 AY315624.1 AY315625.1 AY315626.1 AY315627.1 BC031485.1 BC041598.1 BC137287.1 CR598320.1 CR607505.1 CR614552.1 CR626022.1
21 DOTS entries : DT.100736812 DT.100736813 DT.101985128 DT.101962203 DT.95073752 DT.101985129 DT.453728 DT.40126576 DT.95290901 DT.306840 DT.99980749 DT.40268334 DT.455923 DT.91753337 DT.101959023 DT.120894008 DT.405329 DT.439704 DT.95073749 DT.100804380 DT.120893919
24/310 AceView cDNA sequences (see all 310
):BC031485 AL524713 CK430158 AW501896 AI763183 AL043764 BU188290 BM466101 BU621241 H94252 AA587289 AY315620 AI148943 CR614552 AI420962 BX092918 AI373414 BU538128 BE292887 CK431256 BU844932 BM553580 BQ688966 BE047484
highest scoring ESTs for ACACA :AA082942 AA788920 AY315623 AY315625 AY315626 CF454424 AA011388 AA011425 AA083031 AA101277
Unigene Cluster for ACACA: Acetyl-Coenzyme A carboxylase alpha Hs.160556 [show with all ESTs ] Unigene Representative Sequence: NM_198839 GeneLoc Exon Structure 5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ACACA (see all 10
) ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ SP1 :                     -   -                               SP2 :                                                     SP3 :                                                     SP4 :                       -                               SP5 :     -   -   -   -   -         -                                
ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39a · 39b ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47 ^ SP1 :                                                     SP2 :                                                   -   SP3 :                                                     SP4 :                                                     SP5 :                                                    
ExUns: 48 ^ 49 ^ 50 ^ 51 ^ 52 ^ 53 ^ 54 ^ 55 ^ 56 ^ 57 ^ 58 ^ 59 ^ 60 ^ 61a · 61b ^ 62 ^ 63a · 63b SP1 :                                     SP2 :                                     SP3 :                                     SP4 :                                     SP5 :                                    
About this scheme ECgene alternative splicing isoforms for ACACA 7 Ensembl transcripts including schematic representations : ENST00000394403
ENST00000335166
ENST00000394406
ENST00000361253
ENST00000360679
ENST00000394407
ENST00000353139
Expression for ACACA
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
ACACA expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for ACACA 1 / 2 / 3
7 probe-sets matching ACACA gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CAAGGCTACTSOURCE GeneReport for Unigene cluster: Hs.160556 Expression variation in blood from EXPOLDB for ACACA
UniProtKB/Swiss-Prot: ACACA_HUMAN, Q13085 Tissue specificity : Expressed in brain, placental, skeletal muscle, renal, pancreatic and adiposetissues; expressed at low level in pulmonary tissue; not detected in the liver
Orthologs for ACACA
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Orthologs for ACACA gene from 5/23 species (see all 23
)
About this table Species with no ortholog for ACACA ENSEMBL Gene Tree for ACACA Paralogs for ACACA (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Paralogs for ACACA gene ACACB 2 MCCC1 2
SNPs/Variants for ACACA (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
HapMap Linkage Disequilibrium images for ACACA (up to first 250kb)
Disorders & Mutations for ACACA
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
OMIM: 200350 UniProtKB/Swiss-Prot: ACACA_HUMAN, Q13085
Defects in ACACA are a cause of ACACA deficiency [MIM:200350]; also called ACAC or ACCdeficiency. ACACA deficiency is an inborn error of de novo fatty acid synthesis. The disorder isassociated with severe brain damage, persistent myopathy and poor growth
10 Novoseek disease relationships for ACACA gene
Disease
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
fatty liver
45.46
1
18395093 (1)
hyperinsulinemia
45.42
1
8869748 (1)
insulin sensitivity
44.18
5
16046303 (2), 19169664 (1), 1346611 (1)
insulin resistance
25.68
1
19390150 (1)
ovarian cancer
19.20
4
15333468 (1), 16707454 (1)
breast cancer
9.78
30
15333468 (7), 17372234 (4), 17631500 (3), 16707454 (2) (see all 7 )
shock
0.00
2
12670701 (1)
cancer
0.00
9
17372234 (2), 16061653 (1), 16778563 (1), 18452305 (1) (see all 7 )
tumors
0.00
9
17620310 (2), 17372234 (1), 18794082 (1), 18796435 (1) (see all 5 )
ischemia
0.00
1
11052978 (1)
About this table Human Gene Mutation Database : ACACA Genetic Association Database: ACACA Human Genome Epidemiology Navigator: ACACA (5 documents)
Medical News for ACACA (Possibly Related Articles in
Doctor's Guide )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
--
Publications for ACACA (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
10/213 PubMed articles for ACACA gene (see all 213
): Acetyl-CoA carboxylase alpha gene and breast cancer susceptibility. (PubMed id 15333468) 1, 3, 4, 6 Sinilnikova O.M.... Lenoir G.M. (2004) Human acetyl-CoA carboxylase 1 gene: presence of three promoters and heterogeneity at the 5'-untranslated mRNA region. (PubMed id 12810950) 1, 3, 4 Mao J.... Wakil S.J. (2003) Asymmetric expression of transcripts derived from the shared promoter between the divergently oriented ACACA and TADA2L genes. (PubMed id 15607423) 1, 3, 4 Travers M.T....Joulin V. (2005) Characterisation of an N-terminal variant of acetyl-CoA carboxylase- alpha: expression in human tissues and evolutionary aspects. (PubMed id 14643797) 1, 3, 4 Travers M.T....Barber M.C. (2003) BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase. (PubMed id 16326698) 1, 3, 4 Moreau K.... Venezia N.D. (2006) Human acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms. (PubMed id 7732023) 1, 3, 4 Abu-Elheiga L.... Wakil S.J. (1995) BRCA1 interacts with acetyl-CoA carboxylase through its tandem of BRCT domains. (PubMed id 12360400) 1, 3, 4 Magnard C.... Venezia N.D. (2002) ACCA phosphopeptide recognition by the BRCT repeats of BRCA1. (PubMed id 16698035) 3, 4 Ray H.... Venezia N.D. (2006) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 3, 4 Olsen J.V....Mann M. (2006) Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935) 3, 4 Beausoleil S.A....Gygi S.P. (2004)
Search for ACACA
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Genome Databases showing ACACA
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Other Databases showing ACACA
(According to HUGE )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
--
Specialized Databases showing ACACA (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
-- Services for ACACA (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Products for ACACA:
Antibodies & Assays for ACACA   (Acetyl-CoA carboxylase alpha)
Search Tocris compounds for ACACA
Jump to Section...
Aliases for ACACA
Databases for ACACA
Disorders for ACACA
Domains/Families for ACACA
Drugs/Compounds for ACACA
Expression for ACACA
Function for ACACA
Location for ACACA
Medical News for ACACA
Orthologs for ACACA
Paralogs for ACACA
Pathways/Interactions for ACACA
Proteins for ACACA
Publications for ACACA
SNPs for ACACA
Search Box for ACACA
Services for ACACA
Summaries for ACACA
Technologies for ACACA
Transcripts for ACACA
TOP
BOTTOM
GeneCards Homepage - Last full update: 1 Jul 2009
Incremental update: 13 Oct 2009