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Aliases for ACAA2 Gene

Aliases for ACAA2 Gene

  • Acetyl-CoA Acyltransferase 2 2 3
  • Mitochondrial 3-Oxoacyl-Coenzyme A Thiolase 2 3
  • Mitochondrial 3-Oxoacyl-CoA Thiolase 3 4
  • Acetyl-Coenzyme A Acyltransferase 2 2 3
  • Beta-Ketothiolase 3 4
  • EC 4 63
  • T1 3 4
  • 3-Ketoacyl-CoA Thiolase, Mitochondrial 3
  • Acetyl-CoA Acyltransferase 4
  • Beta Ketothiolase 3
  • EC 2.3.1 63
  • DSAEC 3

External Ids for ACAA2 Gene

Previous GeneCards Identifiers for ACAA2 Gene

  • GC18M047418
  • GC18M047109
  • GC18M047197
  • GC18M045562
  • GC18M045563
  • GC18M047309
  • GC18M044164

Summaries for ACAA2 Gene

Entrez Gene Summary for ACAA2 Gene

  • The encoded protein catalyzes the last step of the mitochondrial fatty acid beta-oxidation spiral. Unlike most mitochondrial matrix proteins, it contains a non-cleavable amino-terminal targeting signal. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACAA2 Gene

ACAA2 (Acetyl-CoA Acyltransferase 2) is a Protein Coding gene. Diseases associated with ACAA2 include akinetic mutism and ketothiolase deficiency. Among its related pathways are Metabolism and Valine, leucine and isoleucine degradation. GO annotations related to this gene include acetyl-CoA C-acyltransferase activity. An important paralog of this gene is ACAT2.

UniProtKB/Swiss-Prot for ACAA2 Gene

  • Abolishes BNIP3-mediated apoptosis and mitochondrial damage.

Gene Wiki entry for ACAA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACAA2 Gene

Genomics for ACAA2 Gene

Regulatory Elements for ACAA2 Gene

Genomic Location for ACAA2 Gene

49,782,167 bp from pter
49,813,960 bp from pter
31,794 bases
Minus strand

Genomic View for ACAA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACAA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACAA2 Gene

Proteins for ACAA2 Gene

  • Protein details for ACAA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    3-ketoacyl-CoA thiolase, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q9BUT6

    Protein attributes for ACAA2 Gene

    397 amino acids
    Molecular mass:
    41924 Da
    Quaternary structure:
    • Homotetramer. Interacts with BNIP3.

    Three dimensional structures from OCA and Proteopedia for ACAA2 Gene

neXtProt entry for ACAA2 Gene

Proteomics data for ACAA2 Gene at MOPED

Post-translational modifications for ACAA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACAA2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ACAA2

Domains for ACAA2 Gene

Suggested Antigen Peptide Sequences for ACAA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the thiolase family.
  • Belongs to the thiolase family.
genes like me logo Genes that share domains with ACAA2: view

No data available for Gene Families for ACAA2 Gene

Function for ACAA2 Gene

Molecular function for ACAA2 Gene

GENATLAS Biochemistry:
acetyl-CoA acyltransferase 2,mitochondrial-3-oxoacyl-coenzyme A,thiolase,concluding the step of fatty acid beta oxidation
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA
UniProtKB/Swiss-Prot Function:
Abolishes BNIP3-mediated apoptosis and mitochondrial damage.

Enzyme Numbers (IUBMB) for ACAA2 Gene

Gene Ontology (GO) - Molecular Function for ACAA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0003988 acetyl-CoA C-acyltransferase activity NAS 8241273
GO:0005515 protein binding IPI 18371312
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ACAA2: view

Animal Model Products

miRNA for ACAA2 Gene

miRTarBase miRNAs that target ACAA2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACAA2

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for ACAA2 Gene

Localization for ACAA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACAA2 Gene

Mitochondrion. Note=Colocalizes with BNIP3 in the mitochondria.

Subcellular locations from

Jensen Localization Image for ACAA2 Gene COMPARTMENTS Subcellular localization image for ACAA2 gene
Compartment Confidence
mitochondrion 5
cytosol 2
peroxisome 2
chloroplast 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ACAA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion NAS 8241273
GO:0005743 mitochondrial inner membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ACAA2: view

Pathways for ACAA2 Gene

genes like me logo Genes that share pathways with ACAA2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot P42765-THIM_HUMAN

  • Pathway: Lipid metabolism; fatty acid metabolism

Gene Ontology (GO) - Biological Process for ACAA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process IEA --
GO:0006695 cholesterol biosynthetic process NAS 8241273
GO:0008152 metabolic process --
GO:0071456 cellular response to hypoxia IDA 18371312
GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IDA 18371312
genes like me logo Genes that share ontologies with ACAA2: view

Drugs for ACAA2 Gene

(51) HMDB Compounds for ACAA2 Gene

Compound Synonyms Cas Number PubMed IDs
  • (E)-S-2-decenoate
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (E)-S-2-octenoate
  • (2E)-Tetradecenoyl-CoA

(2) Novoseek inferred chemical compound relationships for ACAA2 Gene

Compound -log(P) Hits PubMed IDs
acetoacetyl coa 82.1 1
fatty acid 46.7 1
genes like me logo Genes that share compounds with ACAA2: view

Transcripts for ACAA2 Gene

Unigene Clusters for ACAA2 Gene

Acetyl-CoA acyltransferase 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACAA2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACAA2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11
SP1: -
SP2: - -
SP3: -

Relevant External Links for ACAA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACAA2 Gene

mRNA expression in normal human tissues for ACAA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACAA2 Gene

This gene is overexpressed in Liver (11.2).

Protein differential expression in normal tissues for ACAA2 Gene

This gene is overexpressed in Liver, secretome (20.3), Liver (7.2), and Kidney (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACAA2 Gene

SOURCE GeneReport for Unigene cluster for ACAA2 Gene Hs.200136

genes like me logo Genes that share expressions with ACAA2: view

Expression partners for ACAA2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ACAA2 Gene

Orthologs for ACAA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACAA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ACAA2 35
  • 89.17 (n)
  • 88.66 (a)
ACAA2 36
  • 89 (a)
(Mus musculus)
Mammalia Acaa2 35
  • 83.63 (n)
  • 87.91 (a)
Acaa2 16
Acaa2 36
  • 88 (a)
(Pan troglodytes)
Mammalia ACAA2 35
  • 99.75 (n)
  • 99.24 (a)
ACAA2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Acaa2 35
  • 83.71 (n)
  • 87.41 (a)
(Canis familiaris)
Mammalia ACAA2 36
  • 65 (a)
(Monodelphis domestica)
Mammalia ACAA2 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia ACAA2 36
  • 83 (a)
(Gallus gallus)
Aves ACAA2 35
  • 74.81 (n)
  • 79.35 (a)
ACAA2 36
  • 79 (a)
(Anolis carolinensis)
Reptilia ACAA2 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia acaa2 35
  • 70.04 (n)
  • 75.28 (a)
Str.8304 35
African clawed frog
(Xenopus laevis)
Amphibia acaa2-prov 35
(Danio rerio)
Actinopterygii acaa2 35
  • 69.7 (n)
  • 77.22 (a)
Dr.5520 35
acaa2 36
  • 77 (a)
fruit fly
(Drosophila melanogaster)
Insecta yip2 37
  • 52 (a)
yip2 35
  • 57.87 (n)
  • 59.64 (a)
yip2 36
  • 59 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006821 35
  • 56.09 (n)
  • 60.41 (a)
(Caenorhabditis elegans)
Secernentea F53A2.7 37
  • 55 (a)
F53A2.7 35
  • 58.83 (n)
  • 56.33 (a)
F53A2.7 36
  • 55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERG10 36
  • 37 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1112 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5120 36
  • 61 (a)
Species with no ortholog for ACAA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACAA2 Gene

Gene Tree for ACAA2 (if available)
Gene Tree for ACAA2 (if available)

Paralogs for ACAA2 Gene

Paralogs for ACAA2 Gene

(4) SIMAP similar genes for ACAA2 Gene using alignment to 5 proteins: Pseudogenes for ACAA2 Gene

genes like me logo Genes that share paralogs with ACAA2: view

Variants for ACAA2 Gene

Sequence variations from dbSNP and Humsavar for ACAA2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs79257922 -- 49,809,956(+) GGAAA(C/T)GGACC intron-variant
rs79225424 -- 49,784,890(+) TACAA(A/G)TGCCA intron-variant
rs78816994 -- 49,791,459(+) TTTAC(C/T)ATAAA intron-variant
rs78638818 -- 49,794,031(+) CTCAA(A/G)GGTCC intron-variant
rs78558624 -- 49,805,289(+) AAATA(C/T)TTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACAA2 Gene

Variant ID Type Subtype PubMed ID
nsv516056 CNV Gain 19592680

Relevant External Links for ACAA2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACAA2 Gene

Disorders for ACAA2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ACAA2 Gene in MalaCards »

(3) Diseases for ACAA2 Gene

(3) University of Copenhagen DISEASES for ACAA2 Gene

Relevant External Links for ACAA2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ACAA2: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for ACAA2 Gene

Publications for ACAA2 Gene

  1. Cloning and sequence analysis of a full length cDNA encoding human mitochondrial 3-oxoacyl-CoA thiolase. (PMID: 8241273) Abe H. … Niimi H. (Biochim. Biophys. Acta 1993) 2 3 4
  2. Acetyl-Coenzyme A acyltransferase 2 attenuates the apoptotic effects of BNIP3 in two human cell lines. (PMID: 18371312) Cao W. … Lu H. (Biochim. Biophys. Acta 2008) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PMID: 20571754) Fontaine-Bisson B. … Franks P.W. (Diabetologia 2010) 3 48
  5. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. (PMID: 18193044) Kathiresan S. … Orho-Melander M. (Nat. Genet. 2008) 3 48

Products for ACAA2 Gene

Sources for ACAA2 Gene

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