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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ACAA2 Gene

protein-coding GIFtS: 62
GCID: GC18M047309

acetyl-CoA acyltransferase 2

(Previous name: acetyl-Coenzyme A acyltransferase 2 )

Explore 12 diseases affiliated with
ACAA2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Acetyl-CoA Acyltransferase 2¹ ²		Beta Ketothiolase²
DSAEC¹ ²		Beta-Ketothiolase¹
Acetyl-Coenzyme A Acyltransferase 2¹ ²		Mitochondrial 3-Oxoacyl-Coenzyme A Thiolase²
Mitochondrial 3-Oxoacyl-CoA Thiolase² ³		Beta-Ketothiolase¹
T1² ³		Acetyl-CoA Acyltransferase³
EC 2.3.1.16³ ⁸		EC 2.3.1⁸
3-Ketoacyl-CoA Thiolase, Mitochondrial²

External Ids:	HGNC: 83¹	Entrez Gene: 10449²	Ensembl: ENSG00000167315⁷	OMIM: 604770⁵	UniProtKB: P42765³

Export aliases for ACAA2 gene to outside databases

Previous GC identifers: GC18M047418 GC18M047109 GC18M047197 GC18M045562 GC18M045563 GC18M044164

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACAA2:

The encoded protein catalyzes the last step of the mitochondrial fatty acid beta-oxidation spiral. Unlike most

mitochondrial matrix proteins, it contains a non-cleavable amino-terminal targeting signal. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: THIM_HUMAN, P42765

Function: Abolishes BNIP3-mediated apoptosis and mitochondrial damage

Gene Wiki entry for ACAA2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NC_018929.1 NT_010966.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ACAA2 gene promoter:
Max1 HTF LCR-F1 Arnt YY1 Pax-3 HSF1short ZID Msx-1 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ACAA2 promoter sequence

Search SABiosciences Chromatin IP Primers for ACAA2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACAA2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.1 Ensembl cytogenetic band: 18q21.1 HGNC cytogenetic band: 18q21

ACAA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACAA2 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M047309: view genomic region (about GC identifiers)

Start:	47,309,869 bp from pter	End:	47,340,323 bp from pter
Size:	30,455 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: THIM_HUMAN, P42765 (See protein sequence)

Recommended Name: 3-ketoacyl-CoA thiolase, mitochondrial

Size: 397 amino acids; 41924 Da

Subunit: Homotetramer. Interacts with BNIP3

Subcellular location: Mitochondrion. Note=Colocalizes with BNIP3 in the mitochondria

Secondary accessions: Q9BUT6

Explore the universe of human proteins at neXtProt for ACAA2: NX_P42765

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P42765

4/10 DME Specific Peptides for ACAA2 (P42765) (see all 10)

AKRTPFG

VTAGNAS

GIGPVPA

CIGGGQGI

ACAA2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006102.2

ENSEMBL proteins:

ENSP00000285093 ENSP00000466466 ENSP00000466015 ENSP00000465045 ENSP00000465095

ENSP00000468157

Human Recombinant Protein Products:

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	Uscn Proteins for ACAA2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	NAS	8241273
GO:0005743	mitochondrial inner membrane	IEA	--

ACAA2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for ACAA2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ACAA2 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR002155 Thiolase

IPR020610 Thiolase_AS

IPR020616 Thiolase_N

IPR020617 Thiolase_C

IPR020613 Thiolase_CS

Graphical View of Domain Structure for InterPro Entry P42765

ProtoNet protein and cluster: P42765

1 Blocks protein family: IPB002155 Thiolase

UniProtKB/Swiss-Prot: THIM_HUMAN, P42765

Similarity: Belongs to the thiolase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: THIM_HUMAN, P42765

Function: Abolishes BNIP3-mediated apoptosis and mitochondrial damage

Catalytic activity: Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

Genatlas biochemistry entry for ACAA2:

acetyl-CoA acyltransferase 2,mitochondrial-3-oxoacyl-coenzyme A,thiolase,concluding the step of fatty acid beta

oxidation

Enzyme Numbers (IUBMB): EC 2.3.1.16¹ ² EC 2.3.1²

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACAA2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003988	acetyl-CoA C-acyltransferase activity	NAS	8241273
GO:0005515	protein binding	IPI	18371312

ACAA2 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Fatty Acid Biosynthesis

Fatty Acid Biosynthesis

1.00

Synthesis of bile acids and bile salts

bile acid biosynthesis, neutral pathway

0.52

Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA

Fatty acid elongation in mitochondria

0.44

fatty acid alpha-oxidation II

fatty acid beta-oxidation I

0.39

Branched-chain amino acid catabolism

Valine, leucine and isoleucine degradation

0.39

Pathway sources
See GeneCards unified pathways
Show all pathways

3 BioSystems Pathways for ACAA2

	fatty acid beta-oxidation I
	bile acid biosynthesis, neutral pathway
	Fatty Acid Biosynthesis

4 Kegg Pathways (Kegg details for ACAA2):

	Fatty acid elongation in mitochondria
	Fatty acid metabolism
	Valine, leucine and isoleucine degradation
	Metabolic pathways

UniProtKB/Swiss-Prot: THIM_HUMAN, P42765

Pathway: Lipid metabolism; fatty acid metabolism

ACAA2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ACAA2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/35 Interacting proteins for ACAA2 (P42765³ ENSP00000285093⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 35)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SCP2	P22307³, ENSP00000360569⁴	I2D: score=2 STRING: ENSP00000360569
YWHAG	P61981³	I2D: score=2
DDA1	Q9BW61³	I2D: score=1
KCNMA1	Q12791³	I2D: score=1
SLC2A4	P14672³	I2D: score=1

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006084	acetyl-CoA metabolic process	--	--
GO:0006631	fatty acid metabolic process	IEA	--
GO:0006635	fatty acid beta-oxidation	--	--
GO:0006695	cholesterol biosynthetic process	NAS	8241273
GO:0043066	negative regulation of apoptotic process	IDA	18371312

ACAA2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ACAA2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ACAA2

10/54 HMDB Compounds for ACAA2 (see all 54) About this table

Compound	Synonyms	CAS #	PubMed Ids
(2E)-Decenoyl-CoA	(E)-S-2-decenoate Coenzyme A (see all 15)	10018-95-8	--
(2E)-Dodecenoyl-CoA	2-trans-Dodecenoyl-Coenzyme A (see all 4)	1066-12-2	--
(2E)-Hexadecenoyl-CoA	trans-2-Hexadecenoyl-CoA (see all 4)	4460-95-1	--
(2E)-Octenoyl-CoA	(E)-S-2-octenoate Coenzyme A (see all 16)	10018-94-7	--
(2E)-Tetradecenoyl-CoA	(2E)-Tetradecenoyl-Coenzyme A (see all 8)	38795-33-4	--
2-Methylacetoacetyl-CoA	2-Methyl-3-acetoacetyl-CoA (see all 10)	6712-01-2	--
2-Methylbutyryl-CoA	2-methylbutanoyl-CoA (see all 11)	6712-02-3	--
2-Methylhexanoyl-CoA	2-Methylhexanoyl-CoEnzyme A (see all 5)	--	--
3-Oxodecanoyl-CoA	3-Ketodecanoyl-CoA (see all 3)	50411-91-1	--
3-Oxododecanoyl-CoA	3-oxododecanoyl-coenzyme A	78303-19-2	--

2 Novoseek chemical compound relationships for ACAA2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
acetoacetyl coa	82.1	2	8725269 (1)
fatty acid	46.7	1	18371312 (1)

Search CenterWatch for drugs/clinical trials and news about ACAA2 / THIM

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ACAA2 gene:

NM_006111.2

Unigene Cluster for ACAA2:

Acetyl-CoA acyltransferase 2

Hs.200136 [show with all ESTs]

Unigene Representative Sequence: NM_006111

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000285093(uc002ldw.4) ENST00000589432 ENST00000591171 ENST00000587994

ENST00000586485 ENST00000585948 ENST00000586100

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		hsa-miR-3910 hsa-miR-124 hsa-miR-506 hsa-miR-3714
		SwitchGear 3'UTR luciferase reporter plasmid: ACAA2 3' UTR sequence

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Additional cDNA sequence:

AK054673.1 AK225457.1 AK314462.1 BC001918.1 D16294.1

24/26 DOTS entries (see all 26):

DT.117893 DT.99955345 DT.95314270 DT.121105602 DT.91777567 DT.91777572 DT.95281870 DT.100879448

DT.121105519 DT.100879441 DT.102833996 DT.91777571 DT.102833995 DT.121280736 DT.100037407 DT.212947

DT.95314159 DT.108510 DT.121105500 DT.121105518 DT.121194033 DT.91777580 DT.40307186 DT.92033793

24/640 AceView cDNA sequences (see all 640):

CA439329 BG742061 BM773145 CB161917 BQ892315 BM795429 AW149318 AK054673

AI589503 CA773580 CD674555 AA058529 AI272109 CR610172 BM844087 AI742765

BG180336 AA129619 AK025336 BM678968 BM789850 CR626652 CB306880 AL517117

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ACAA2 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11
SP1:																									-
SP2:					-		-
SP3:							-
SP4:

ECgene alternative splicing isoforms for ACAA2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ACAA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTAGAAGTAC

About this image

ACAA2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Thoracic Perivascular Adipose

Adipose

Brain

Brain

Diencephalic Roof Plate

Neural Tube

Metencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ACAA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACAA2

SOURCE GeneReport for Unigene cluster: Hs.200136

SABiosciences Expression via Pathway-Focused PCR Arrays including ACAA2:

Fatty Acid Metabolism in human mouse rat

Amino Acid Metabolism II in human mouse rat

Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

PPAR Targets in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACAA2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ACAA2 gene from 6/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ACAA2¹	acetyl-CoA acyltransferase 2	74.81(n) 79.35(a)		426847 NM_001006571.1 NP_001006571.1
lizard (Anolis carolinensis)	Reptilia	ACAA2⁶	--	80(a)	1 ↔ 1	2(17143-29605)
African clawed frog (Xenopus laevis)	Amphibia	acaa2-prov²	acetyl-Coenzyme A acyltransferase 2 (mitochondrial more	75.6(n)		BC045119.1
zebrafish (Danio rerio)	Actinopterygii	Dr.5520²	Danio rerio mRNA similar to DNA segment, Chr 18, ERATO more	74.74(n)		BC045876.1
fruit fly (Drosophila melanogaster)	Insecta	yip2^{1 , 3}	acetyl-CoA C-acyltransferase³ yippee interacting protein 2¹	52(a)³ 57.87(n)¹ 59.64(a)¹		30E4³ 34313¹ NM_078804.3¹ NP_523528.1¹
worm (Caenorhabditis elegans)	Secernentea	F53A2.7^{1 , 3}	Thiolases³ Protein F53A2.7¹	55(a)³ 58.66(n)¹ 56.33(a)¹		III(13416064-13417212)³ 176756¹ NM_067351.5¹ NP_499752.2¹

ENSEMBL Gene Tree for ACAA2 (if available)
TreeFam Gene Tree for ACAA2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ACAA2 gene

ACAT1² ACAT2²

4 SIMAP similar genes for ACAA2 using alignment to 5 protein entries: THIM_HUMAN (see all proteins):

ACAT2 ACAA1 ACAT1 HADHB

ACAA2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ACAA2
PGOHUM00000241289

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs506664^1,2	H	--	47309431(+)	`TTAAGC/TTGgga`	1	--	ds500¹		4		NS EA	404
rs148817561^1,2		--	47309433(+)	`AAGCTA/GGGAAG`	1	--	ds500¹		0	--	--	--	--
rs143462465^1,2		--	47309435(+)	`GCTGGG/TAAGAA`	1	--	ds500¹		0	--	--	--	--
rs35917921^1,2	C,F,	--	47309523(+)	`AAGGTG/AGATGA`	1	--	ds500¹		8		NA WA EA	368
rs75276171^1,2	F,	--	47309540(+)	`AGAACA/GTTATA`	1	--	ds500¹		3		WA NA EA	358
rs189808686^1,2		--	47309602(+)	`ACTTAC/TGAGGT`	1	--	ds500¹		0	--	--	--	--
rs147997757^1,2		--	47309617(+)	`CGAGTC/GATCAA`	1	--	ds500¹		0	--	--	--	--
rs78198328^1,2		--	47309673(+)	`TGGGAG/CAATCA`	1	--	ds500¹		2		CSA WA	120
rs142479593^1,2		--	47309820(+)	`ATGTGA/TATCTT`	1	--	ds500¹		0	--	--	--	--
rs111919229^1,2	C	--	47309882(+)	`AGTTAT/AGGCAA`	1	--	ut3¹		1		CSA	1

HapMap Linkage Disequilibrium report for ACAA2 (47309869 - 47340323 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ACAA2
1 CNV: 49999

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ACAA2 for disorders           About GeneDecksing

OMIM gene information: 604770    OMIM disorders: --

12 diseases for ACAA2:    About MalaCards

beta-ketothiolase deficiency rhizomelic chondrodysplasia punctata akinetic mutism ketothiolase deficiency

chondrodysplasia punctata mutism zellweger syndrome adrenoleukodystrophy

chondrodysplasia cholesterol tuberculosis mycobacterium tuberculosis

1 disease from the University of Copenhagen DISEASES database for ACAA2:

Akinetic mutism

Human Genome Epidemiology (HuGE) Navigator: ACAA2 (4 documents)

Export disorders for ACAA2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ACAA2 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with ACAA2)

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world of online information

Cloning and sequence analysis of a full length cDNA encoding human mitochondrial 3-oxoacyl-CoA thiolase. (PubMed id 8241273)^{1, 2, 3} Abe H.... Niimi H. (1993)
Acetyl-Coenzyme A acyltransferase 2 attenuates the apoptotic effects of BNIP3 in two human cell lines. (PubMed id 18371312)^{1, 2, 9} Cao W....Lu H. (2008)
Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. (PubMed id 15242332)^{1, 2} Aboulaich N.... Vener A.V. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population. (PubMed id 20972250)¹ Park M.H....Park H.Y. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10449	HGNC: 83	AceView: ACAA2andMYO5B	Ensembl:ENSG00000167315	euGenes: HUgn10449
ECgene: ACAA2	Kegg: 10449	H-InvDB: ACAA2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ACAA2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ACAA2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ACAA2 gene:
Search GeneIP for patents involving ACAA2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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acetyl-CoA acyltransferase 2

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acetyl-CoA acyltransferase 2

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