Aliases for ABT1 Gene
Aliases for ABT1 Gene
External Ids for ABT1 Gene
- HGNC: 17369
- Entrez Gene: 29777
- Ensembl: ENSG00000146109
- UniProtKB: Q9ULW3
Previous GeneCards Identifiers for ABT1 Gene
- GC06P026654
- GC06P026705
- GC06P026597
- GC06P026540
- GC06P026604
- GC06P026651
- GC06P026693
- GC06P026737
- GC06P026775
- GC06P026837
- GC06P026937
Summaries for ABT1 Gene
-
Basal transcription of genes by RNA polymerase II requires the interaction of TATA-binding protein (TBP) with the core region of class II promoters. Studies in mouse suggest that the protein encoded by this gene likely activates basal transcription from class II promoters by interaction with TBP and the class II promoter DNA. [provided by RefSeq, Jul 2008]
GeneCards Summary for ABT1 Gene
ABT1 (Activator Of Basal Transcription 1) is a Protein Coding gene. Diseases associated with ABT1 include Neuronal Intranuclear Inclusion Disease. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity.
UniProtKB/Swiss-Prot for ABT1 Gene
-
Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity).
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABT1 Gene
Genomics for ABT1 Gene
GeneHancer (GH) Regulatory Elements for ABT1 Gene
Promoters and enhancers for ABT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ABT1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ABT1 Gene
Genomic Locations for ABT1 Gene
- chr6:26,596,943-26,600,744
- (GRCh38/hg38)
- Size:
- 3,802 bases
- Orientation:
- Plus strand
- chr6:26,597,171-26,600,278
- (GRCh37/hg19)
Genomic View for ABT1 Gene
Genes around ABT1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.2 by Ensembl
- 6p22.2 by Entrez Gene
- 6p22.2 by HGNC
ABT1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ABT1 Gene
Proteins for ABT1 Gene
-
Protein details for ABT1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9ULW3-ABT1_HUMAN
- Recommended name:
- Activator of basal transcription 1
- Protein Accession:
- Q9ULW3
Protein attributes for ABT1 Gene
- Size:
- 272 amino acids
- Molecular mass:
- 31079 Da
- Quaternary structure:
-
- Interacts with ESF1/ABTAP (By similarity). Interacts with IGHMBP2.
Protein Expression for ABT1 Gene
Post-translational modifications for ABT1 Gene
- Ubiquitination at Lys146
Other Protein References for ABT1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ABT1
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- GeneTex ABT1 antibody for ABT1
-
Santa Cruz Biotechnology (SCBT) Antibodies for ABT1
Protein Products
-
OriGene Purified Proteins for ABT1
- Search Origene for MassSpec and Protein Over-expression Lysates for ABT1
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- Search GeneTex for Proteins for ABT1
-
Abcam proteins for ABT1
Assay Products
No data available for DME Specific Peptides for ABT1 Gene
Domains & Families for ABT1 Gene
Gene Families for ABT1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ABT1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ABT1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9ULW3- Family:
-
- Belongs to the ESF2/ABP1 family.
Function for ABT1 Gene
Molecular function for ABT1 Gene
- UniProtKB/Swiss-Prot Function:
- Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity).
Phenotypes From GWAS Catalog for ABT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003713 | transcription coactivator activity | TAS | 10648625 |
| GO:0003723 | RNA binding | IBA | -- |
| GO:0005515 | protein binding | IPI | 19299493 |
Phenotypes for ABT1 Gene
Animal Model Products
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-
-
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-
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miRNA for ABT1 Gene
- miRTarBase miRNAs that target ABT1
-
- hsa-mir-124-3p (MIRT023111)
- hsa-mir-196a-5p (MIRT026032)
- hsa-mir-98-5p (MIRT027859)
- hsa-let-7d-5p (MIRT032165)
- hsa-mir-615-3p (MIRT039696)
- hsa-mir-193b-3p (MIRT041584)
- hsa-mir-328-3p (MIRT043755)
- hsa-mir-186-5p (MIRT044910)
- hsa-let-7a-5p (MIRT100091)
- hsa-let-7b-5p (MIRT100092)
- hsa-let-7c-5p (MIRT100093)
- hsa-let-7e-5p (MIRT100094)
- hsa-let-7f-5p (MIRT100095)
- hsa-let-7g-5p (MIRT100096)
- hsa-let-7i-5p (MIRT100097)
- hsa-mir-379-5p (MIRT100098)
- hsa-mir-325 (MIRT100099)
- hsa-mir-628-3p (MIRT100100)
- hsa-mir-2278 (MIRT100101)
- hsa-mir-3918 (MIRT100102)
- hsa-mir-3927-3p (MIRT100103)
- hsa-mir-4458 (MIRT100104)
- hsa-mir-4500 (MIRT100105)
- hsa-mir-4640-5p (MIRT100106)
- hsa-mir-3529-5p (MIRT100107)
- hsa-mir-4726-5p (MIRT100108)
- hsa-mir-4524b-3p (MIRT100109)
- hsa-mir-6132 (MIRT100110)
- hsa-mir-6501-3p (MIRT100111)
- hsa-mir-6510-5p (MIRT100112)
- hsa-mir-6828-5p (MIRT100113)
- hsa-mir-6831-5p (MIRT100114)
- hsa-mir-6836-5p (MIRT100115)
- hsa-mir-6895-5p (MIRT100116)
- hsa-mir-382-3p (MIRT257487)
- hsa-mir-3202 (MIRT360310)
- hsa-mir-4694-3p (MIRT360312)
- hsa-mir-5093 (MIRT360313)
- hsa-mir-548an (MIRT408723)
- hsa-mir-5582-5p (MIRT408724)
- hsa-mir-202-3p (MIRT490467)
- hsa-mir-4533 (MIRT540729)
- hsa-mir-4482-3p (MIRT564202)
- hsa-mir-7159-3p (MIRT564203)
- hsa-mir-548c-3p (MIRT564204)
- hsa-mir-655-3p (MIRT573132)
- hsa-mir-374c-5p (MIRT573133)
- hsa-mir-6735-3p (MIRT573134)
- hsa-mir-3677-5p (MIRT573135)
- hsa-mir-3607-3p (MIRT573136)
- hsa-mir-429 (MIRT573137)
- hsa-mir-200c-3p (MIRT573138)
- hsa-mir-200b-3p (MIRT573139)
- hsa-mir-8084 (MIRT573140)
- hsa-mir-5582-3p (MIRT573141)
- hsa-mir-548f-3p (MIRT573142)
- hsa-mir-548e-3p (MIRT573143)
- hsa-mir-548az-3p (MIRT573144)
- hsa-mir-548ar-3p (MIRT573145)
- hsa-mir-548a-3p (MIRT573146)
miRNA Products
- Search ViGene Biosciences for ABT1
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-
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 118 available Activator of Basal Transcription 1 gene related products
- Overview of 118 available Activator of Basal Transcription 1 gene related products
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- Applied Biological Materials Clones for ABT1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for ABT1 gene
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABT1 Gene
Localization for ABT1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ABT1 Gene
- Nucleus. Nucleus, nucleolus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS | 10648625 |
| GO:0005667 | transcription factor complex | IEA | -- |
| GO:0005730 | nucleolus | IBA | -- |
Pathways & Interactions for ABT1 Gene
No Data Available
Interacting Proteins for ABT1 Gene
Selected Interacting proteins:
ENSP00000274849
Q9ULW3-ABT1_HUMAN
for ABT1 Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | IBA | -- |
| GO:0000472 | endonucleolytic cleavage to generate mature 5-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | IBA | -- |
| GO:0000480 | endonucleolytic cleavage in 5-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | IBA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ABT1 Gene
Transcripts for ABT1 Gene
mRNA/cDNA for ABT1 Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (261) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ABT1 Gene
CRISPR Products
-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ABT1
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miRNA Products
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Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for ABT1 gene
Clone Products
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- VectorBuilder custom plasmid, inducible vectors for ABT1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ABT1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 118 available Activator of Basal Transcription 1 gene related products
- Overview of 118 available Activator of Basal Transcription 1 gene related products
- orf clones - Search results for 118 available Activator of Basal Transcription 1 gene related products
- Overview of 118 available Activator of Basal Transcription 1 gene related products
- Applied Biological Materials Clones for ABT1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ABT1 Gene
This gene is overexpressed in Plasma (22.3), Peripheral blood mononuclear cells (20.0), and Lung (7.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABT1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ABT1 Gene:
ABT1SOURCE GeneReport for Unigene cluster for ABT1 Gene:
Hs.254406Evidence on tissue expression from TISSUES for ABT1 Gene
- Intestine(4.2)
Primer Products
-
OriGene qPCR primer pairs for ABT1
-
OriGene qPCR primer pairs and template standards for ABT1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABT1 Gene
Orthologs for ABT1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ABT1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | ABT1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ABT1 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Abt1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Abt1 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ABT1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ABT1 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ABT1 34 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | MGC52939 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | abt1 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG32708 34 |
|
OneToMany | |
| CG41562 34 |
|
OneToMany | |||
| CG40813 34 |
|
OneToMany | |||
| CG10993 34 |
|
OneToMany | |||
| CG32706 34 |
|
OneToMany | |||
| CG6999 34 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | F57B10.8 34 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ESF2 34 36 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4929 34 |
|
OneToOne |
- Species where no ortholog for ABT1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for ABT1 Gene
Pseudogenes.org Pseudogenes for ABT1 Gene
No data available for Paralogs for ABT1 Gene
Variants for ABT1 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000081617 | -- | 26,597,780(+) | C/A | intron_variant | |
| rs1001223960 | -- | 26,599,185(+) | A/G | 3_prime_UTR_variant | |
| rs1002192605 | -- | 26,600,500(+) | C/T | downstream_transcript_variant | |
| rs1002255267 | -- | 26,595,117(+) | G/A | upstream_transcript_variant | |
| rs1005200017 | -- | 26,596,975(+) | C/T | 5_prime_UTR_variant |
Residual Variation Intolerance Score:
16.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.30;
41.11% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ABT1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ABT1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ABT1 Gene
Disorders for ABT1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| neuronal intranuclear inclusion disease |
|
|
Search ABT1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ABT1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ABT1 Gene
Publications for ABT1 Gene
- A novel TATA-binding protein-binding protein, ABT1, activates basal transcription and has a yeast homolog that is essential for growth. (PMID: 10648625) Oda T … Muramatsu MA (Molecular and cellular biology 2000) 2 3 4 58
- Biochemical and genetic evidence for a role of IGHMBP2 in the translational machinery. (PMID: 19299493) de Planell-Saguer M … Mourelatos Z (Human molecular genetics 2009) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for ABT1 Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available Activator of Basal Transcription 1 related products ranked by validation data
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- antibodies-online: Search results for 8 available Activator of Basal Transcription 1 Proteins ranked by validation data
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- genomics-online: cdna clones - Search results for 118 available Activator of Basal Transcription 1 gene related products
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Sources for ABT1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
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