Aliases for ABT1 Gene
Aliases for ABT1 Gene
External Ids for ABT1 Gene
- HGNC: 17369
- Entrez Gene: 29777
- Ensembl: ENSG00000146109
- UniProtKB: Q9ULW3
Previous GeneCards Identifiers for ABT1 Gene
- GC06P026654
- GC06P026705
- GC06P026597
- GC06P026540
- GC06P026604
- GC06P026651
- GC06P026693
- GC06P026737
Summaries for ABT1 Gene
-
Basal transcription of genes by RNA polymerase II requires the interaction of TATA-binding protein (TBP) with the core region of class II promoters. Studies in mouse suggest that the protein encoded by this gene likely activates basal transcription from class II promoters by interaction with TBP and the class II promoter DNA. [provided by RefSeq, Jul 2008]
GeneCards Summary for ABT1 Gene
ABT1 (Activator Of Basal Transcription 1) is a Protein Coding gene. Diseases associated with ABT1 include Neuronal Intranuclear Inclusion Disease. GO annotations related to this gene include poly(A) RNA binding and transcription coactivator activity.
UniProtKB/Swiss-Prot for ABT1 Gene
-
Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity).
No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABT1 Gene
Genomics for ABT1 Gene
Regulatory Elements for ABT1 Gene
Enhancers for ABT1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ABT1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for ABT1 Gene
- Chromosome:
- 6
- Start:
- 26,596,943 bp from pter
- End:
- 26,600,744 bp from pter
- Size:
- 3,802 bases
- Orientation:
- Plus strand
Genomic View for ABT1 Gene
Genes around ABT1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.2 by Ensembl
- 6p22.2 by Entrez Gene
- 6p22.2 by HGNC
ABT1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ABT1 Gene
Proteins for ABT1 Gene
-
Protein details for ABT1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9ULW3-ABT1_HUMAN
- Recommended name:
- Activator of basal transcription 1
- Protein Accession:
- Q9ULW3
Protein attributes for ABT1 Gene
- Size:
- 272 amino acids
- Molecular mass:
- 31079 Da
- Quaternary structure:
-
- Interacts with ESF1/ABTAP (By similarity). Interacts with IGHMBP2.
Protein Expression for ABT1 Gene
Post-translational modifications for ABT1 Gene
Other Protein References for ABT1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ABT1
- Invitrogen Antibodies for ABT1
- antibodies-online Antibodies for ABT1: See all 35
- GeneTex ABT1 antibody for ABT1
-
St John's Laboratory Antibodies for ABT1
-
Santa Cruz Biotechnology (SCBT) Antibodies for ABT1
Protein Products
-
OriGene Purified Proteins for ABT1
- Search Origene for MassSpec and Protein Over-expression Lysates for ABT1
- Origene Custom Protein Services for ABT1
- antibodies-online Proteins for ABT1: See all 10
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ABT1
Assay Products
- antibodies-online Kits for ABT1: See all 1
No data available for DME Specific Peptides for ABT1 Gene
Domains & Families for ABT1 Gene
Protein Domains for ABT1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ABT1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9ULW3UniProtKB/Swiss-Prot:
ABT1_HUMAN :- Contains 1 RRM (RNA recognition motif) domain.
- Belongs to the ESF2/ABP1 family.
- Domain:
-
- Contains 1 RRM (RNA recognition motif) domain.
- Family:
-
- Belongs to the ESF2/ABP1 family.
No data available for Gene Families for ABT1 Gene
Function for ABT1 Gene
Molecular function for ABT1 Gene
- UniProtKB/Swiss-Prot Function:
- Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003713 | transcription coactivator activity | TAS | 10648625 |
| GO:0003723 | RNA binding | IEA,IBA | -- |
| GO:0005515 | protein binding | IPI | 19299493 |
Phenotypes for ABT1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ABT1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ABT1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ABT1 gene
- Search ViGene Biosciences for ABT1
CRISPR Products
-
OriGene CRISPR knockouts for ABT1
- GenScript: Design CRISPR guide RNA sequences for ABT1
miRNA for ABT1 Gene
- miRTarBase miRNAs that target ABT1
-
- hsa-mir-124-3p (MIRT023111)
- hsa-mir-196a-5p (MIRT026032)
- hsa-mir-98-5p (MIRT027859)
- hsa-let-7d-5p (MIRT032165)
- hsa-mir-615-3p (MIRT039696)
- hsa-mir-193b-3p (MIRT041584)
- hsa-mir-328-3p (MIRT043755)
- hsa-mir-186-5p (MIRT044910)
- hsa-let-7a-5p (MIRT100091)
- hsa-let-7b-5p (MIRT100092)
- hsa-let-7c-5p (MIRT100093)
- hsa-let-7e-5p (MIRT100094)
- hsa-let-7f-5p (MIRT100095)
- hsa-let-7g-5p (MIRT100096)
- hsa-let-7i-5p (MIRT100097)
- hsa-mir-379-5p (MIRT100098)
- hsa-mir-325 (MIRT100099)
- hsa-mir-628-3p (MIRT100100)
- hsa-mir-2278 (MIRT100101)
- hsa-mir-3918 (MIRT100102)
- hsa-mir-3927-3p (MIRT100103)
- hsa-mir-4458 (MIRT100104)
- hsa-mir-4500 (MIRT100105)
- hsa-mir-4640-5p (MIRT100106)
- hsa-mir-3529-5p (MIRT100107)
- hsa-mir-4726-5p (MIRT100108)
- hsa-mir-4524b-3p (MIRT100109)
- hsa-mir-6132 (MIRT100110)
- hsa-mir-6501-3p (MIRT100111)
- hsa-mir-6510-5p (MIRT100112)
- hsa-mir-6828-5p (MIRT100113)
- hsa-mir-6831-5p (MIRT100114)
- hsa-mir-6836-5p (MIRT100115)
- hsa-mir-6895-5p (MIRT100116)
- hsa-mir-382-3p (MIRT257487)
- hsa-mir-3202 (MIRT360310)
- hsa-mir-4694-3p (MIRT360312)
- hsa-mir-5093 (MIRT360313)
- hsa-mir-548an (MIRT408723)
- hsa-mir-5582-5p (MIRT408724)
- hsa-mir-202-3p (MIRT490467)
- hsa-mir-4533 (MIRT540729)
- hsa-mir-4482-3p (MIRT564202)
- hsa-mir-7159-3p (MIRT564203)
- hsa-mir-548c-3p (MIRT564204)
- hsa-mir-655-3p (MIRT573132)
- hsa-mir-374c-5p (MIRT573133)
- hsa-mir-6735-3p (MIRT573134)
- hsa-mir-3677-5p (MIRT573135)
- hsa-mir-3607-3p (MIRT573136)
- hsa-mir-429 (MIRT573137)
- hsa-mir-200c-3p (MIRT573138)
- hsa-mir-200b-3p (MIRT573139)
- hsa-mir-8084 (MIRT573140)
- hsa-mir-5582-3p (MIRT573141)
- hsa-mir-548f-3p (MIRT573142)
- hsa-mir-548e-3p (MIRT573143)
- hsa-mir-548az-3p (MIRT573144)
- hsa-mir-548ar-3p (MIRT573145)
- hsa-mir-548a-3p (MIRT573146)
miRNA Products
- Search ViGene Biosciences for ABT1
Clone Products
- Sino Biological Human cDNA Clone for ABT1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ABT1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ABT1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for ABT1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ABT1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ABT1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABT1 Gene
Localization for ABT1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ABT1 Gene
- Nucleus. Nucleus, nucleolus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS | 10648625 |
| GO:0005667 | transcription factor complex | IEA | -- |
| GO:0005730 | nucleolus | IEA,IBA | -- |
Pathways & Interactions for ABT1 Gene
No Data Available
Interacting Proteins for ABT1 Gene
Selected Interacting proteins:
ENSP00000274849
Q9ULW3-ABT1_HUMAN
for ABT1 Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | IBA | -- |
| GO:0000472 | endonucleolytic cleavage to generate mature 5-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | IBA | -- |
| GO:0000480 | endonucleolytic cleavage in 5-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | IBA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ABT1 Gene
Transcripts for ABT1 Gene
mRNA/cDNA for ABT1 Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (261) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ABT1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ABT1
- GenScript: Design CRISPR guide RNA sequences for ABT1
miRNA Products
- Search ViGene Biosciences for ABT1
Clone Products
- Sino Biological Human cDNA Clone for ABT1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ABT1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ABT1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for ABT1 Gene
This gene is overexpressed in Plasma (22.3), Peripheral blood mononuclear cells (20.0), and Lung (7.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABT1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ABT1 Gene:
ABT1SOURCE GeneReport for Unigene cluster for ABT1 Gene:
Hs.254406Primer Products
-
OriGene qPCR primer pairs and template standards for ABT1
-
OriGene qPCR primer pairs for ABT1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ABT1 Gene
Orthologs for ABT1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ABT1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ABT1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ABT1 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Abt1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Abt1 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ABT1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ABT1 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ABT1 35 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | MGC52939 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | abt1 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG32708 35 |
|
OneToMany | |
| CG41562 35 |
|
OneToMany | |||
| CG40813 35 |
|
OneToMany | |||
| CG10993 35 |
|
OneToMany | |||
| CG32706 35 |
|
OneToMany | |||
| CG6999 35 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | F57B10.8 35 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ESF2 35 37 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4929 35 |
|
OneToOne |
- Species where no ortholog for ABT1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for ABT1 Gene
Pseudogenes.org Pseudogenes for ABT1 Gene
No data available for Paralogs for ABT1 Gene
Variants for ABT1 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs10719210 | -- | 26,595,198(+) | CTTCA(-/T)TTTTT | upstream-variant-2KB | |
| rs111797336 | -- | 26,597,577(+) | TTCTA(C/G)AAAAC | intron-variant | |
| rs111922578 | -- | 26,599,881(+) | ATTAT(A/G)ATTTC | utr-variant-3-prime | |
| rs113057370 | -- | 26,597,959(+) | GGAGG(-/G)AAAAA | reference, frameshift-variant | |
| rs113670588 | -- | 26,598,383(+) | CTATC(C/T)TCAAA | reference, missense |
Residual Variation Intolerance Score:
16.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.30;
41.11% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ABT1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ABT1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ABT1 Gene
Disorders for ABT1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| neuronal intranuclear inclusion disease |
|
|
Search ABT1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for ABT1
No data available for UniProtKB/Swiss-Prot and Genatlas for ABT1 Gene
Publications for ABT1 Gene
- A novel TATA-binding protein-binding protein, ABT1, activates basal transcription and has a yeast homolog that is essential for growth. (PMID: 10648625) Oda T. … Muramatsu M.-A. (Mol. Cell. Biol. 2000) 2 3 4 64
- Biochemical and genetic evidence for a role of IGHMBP2 in the translational machinery. (PMID: 19299493) de Planell-Saguer M. … Mourelatos Z. (Hum. Mol. Genet. 2009) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
Products for ABT1 Gene
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- antibodies-online Antibodies for ABT1: See all 35
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- antibodies-online Proteins for ABT1: See all 10
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- GeneTex ABT1 antibody for ABT1
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- ViGene Biosciences adenoviral particle packaged cDNA for ABT1 gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for ABT1
- VectorBuilder custom plasmid, inducible vectors for ABT1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ABT1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ABT1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
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