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Aliases for ABT1 Gene

Aliases for ABT1 Gene

  • Activator Of Basal Transcription 1 2 3 5
  • Basal Transcriptional Activator 3 4
  • HABT1 3 4
  • TATA-Binding Protein-Binding Protein 3

External Ids for ABT1 Gene

Previous GeneCards Identifiers for ABT1 Gene

  • GC06P026654
  • GC06P026705
  • GC06P026597
  • GC06P026540
  • GC06P026604
  • GC06P026651
  • GC06P026693
  • GC06P026737

Summaries for ABT1 Gene

Entrez Gene Summary for ABT1 Gene

  • Basal transcription of genes by RNA polymerase II requires the interaction of TATA-binding protein (TBP) with the core region of class II promoters. Studies in mouse suggest that the protein encoded by this gene likely activates basal transcription from class II promoters by interaction with TBP and the class II promoter DNA. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABT1 Gene

ABT1 (Activator Of Basal Transcription 1) is a Protein Coding gene. Diseases associated with ABT1 include Neuronal Intranuclear Inclusion Disease. GO annotations related to this gene include poly(A) RNA binding and transcription coactivator activity.

UniProtKB/Swiss-Prot for ABT1 Gene

  • Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABT1 Gene

Genomics for ABT1 Gene

Regulatory Elements for ABT1 Gene

Enhancers for ABT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F026567 0.8 Ensembl ENCODE 66.7 -26.4 -26442 5.4 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ABT1 HMGN4 BTN3A2 GUSBP2 LOC102724851 BTN2A1 ZNF391 HCG11 RNU6-502P HIST1H1D
GH06F027126 0.9 Ensembl ENCODE 64.5 +541.1 541094 23.0 CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ZFP41 ABT1 ZKSCAN8 HMGN4 LOC102724851 ZNF391 ZNF204P ZNF322 HNRNPA1P1 HIST1H4K VN1R11P
GH06F027495 0.4 ENCODE 63.3 +898.8 898791 1.2 PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 ZNF2 ZNF302 ZNF143 FOS ZKSCAN8 ZKSCAN3 ABT1 ZSCAN9 ZKSCAN4 HMGN4 ZNF391 GUSBP2 ZNF322 ZNF204P
GH06F026283 0.6 ENCODE 57.6 -311.9 -311869 3.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ABT1 HMGN4 HIST1H2APS4 HIST1H2APS5 ENSG00000271071 HIST1H2BPS1 HIST1H2BA VN1R11P VN1R13P LOC442172
GH06F026193 0.2 ENCODE 57.6 -396.2 -396152 14.6 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 ABT1 HMGN4 BTN3A2 HIST1H3E GUSBP2 ZNF322 HIST1H2AE HIST1H2BE LARP1P1 HIST1H2APS3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ABT1 on UCSC Golden Path with GeneCards custom track

Promoters for ABT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001404891 -1042 4200 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263

Genomic Location for ABT1 Gene

Chromosome:
6
Start:
26,596,943 bp from pter
End:
26,600,744 bp from pter
Size:
3,802 bases
Orientation:
Plus strand

Genomic View for ABT1 Gene

Genes around ABT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABT1 Gene

Proteins for ABT1 Gene

  • Protein details for ABT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULW3-ABT1_HUMAN
    Recommended name:
    Activator of basal transcription 1
    Protein Accession:
    Q9ULW3

    Protein attributes for ABT1 Gene

    Size:
    272 amino acids
    Molecular mass:
    31079 Da
    Quaternary structure:
    • Interacts with ESF1/ABTAP (By similarity). Interacts with IGHMBP2.

neXtProt entry for ABT1 Gene

Post-translational modifications for ABT1 Gene

  • Ubiquitination at Lys 146
  • Modification sites at PhosphoSitePlus

Other Protein References for ABT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ABT1 Gene

Domains & Families for ABT1 Gene

Protein Domains for ABT1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ABT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULW3

UniProtKB/Swiss-Prot:

ABT1_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
  • Belongs to the ESF2/ABP1 family.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the ESF2/ABP1 family.
genes like me logo Genes that share domains with ABT1: view

No data available for Gene Families for ABT1 Gene

Function for ABT1 Gene

Molecular function for ABT1 Gene

UniProtKB/Swiss-Prot Function:
Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity).

Gene Ontology (GO) - Molecular Function for ABT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003677 DNA binding IEA --
GO:0003713 transcription coactivator activity TAS 10648625
GO:0003723 RNA binding IEA,IBA --
GO:0005515 protein binding IPI 19299493
genes like me logo Genes that share ontologies with ABT1: view
genes like me logo Genes that share phenotypes with ABT1: view

Animal Model Products

miRNA for ABT1 Gene

miRTarBase miRNAs that target ABT1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABT1 Gene

Localization for ABT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABT1 Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABT1 Gene COMPARTMENTS Subcellular localization image for ABT1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ABT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10648625
GO:0005667 transcription factor complex IEA --
GO:0005730 nucleolus IEA,IBA --
genes like me logo Genes that share ontologies with ABT1: view

Pathways & Interactions for ABT1 Gene

SuperPathways for ABT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ABT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0000472 endonucleolytic cleavage to generate mature 5-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0000480 endonucleolytic cleavage in 5-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ABT1: view

No data available for Pathways by source and SIGNOR curated interactions for ABT1 Gene

Drugs & Compounds for ABT1 Gene

(7) Drugs for ABT1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ABT1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ABT1: view

Transcripts for ABT1 Gene

mRNA/cDNA for ABT1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(261) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ABT1 Gene

Activator of basal transcription 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABT1 Gene

No ASD Table

Relevant External Links for ABT1 Gene

GeneLoc Exon Structure for
ABT1
ECgene alternative splicing isoforms for
ABT1

Expression for ABT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ABT1 Gene

Protein differential expression in normal tissues from HIPED for ABT1 Gene

This gene is overexpressed in Plasma (22.3), Peripheral blood mononuclear cells (20.0), and Lung (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABT1 Gene



Protein tissue co-expression partners for ABT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ABT1 Gene:

ABT1

SOURCE GeneReport for Unigene cluster for ABT1 Gene:

Hs.254406
genes like me logo Genes that share expression patterns with ABT1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ABT1 Gene

Orthologs for ABT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ABT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABT1 34 35
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia ABT1 34 35
  • 84.8 (n)
cow
(Bos Taurus)
Mammalia ABT1 34 35
  • 83.21 (n)
rat
(Rattus norvegicus)
Mammalia Abt1 34
  • 82.56 (n)
mouse
(Mus musculus)
Mammalia Abt1 34 16 35
  • 78.83 (n)
oppossum
(Monodelphis domestica)
Mammalia ABT1 35
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABT1 35
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABT1 35
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52939 34
zebrafish
(Danio rerio)
Actinopterygii abt1 34 35
  • 56.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32708 35
  • 31 (a)
OneToMany
CG41562 35
  • 29 (a)
OneToMany
CG40813 35
  • 28 (a)
OneToMany
CG10993 35
  • 27 (a)
OneToMany
CG32706 35
  • 24 (a)
OneToMany
CG6999 35
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F57B10.8 35
  • 26 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ESF2 35 37
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4929 35
  • 37 (a)
OneToOne
Species where no ortholog for ABT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ABT1 Gene

ENSEMBL:
Gene Tree for ABT1 (if available)
TreeFam:
Gene Tree for ABT1 (if available)

Paralogs for ABT1 Gene

Pseudogenes.org Pseudogenes for ABT1 Gene

genes like me logo Genes that share paralogs with ABT1: view

No data available for Paralogs for ABT1 Gene

Variants for ABT1 Gene

Sequence variations from dbSNP and Humsavar for ABT1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10719210 -- 26,595,198(+) CTTCA(-/T)TTTTT upstream-variant-2KB
rs111797336 -- 26,597,577(+) TTCTA(C/G)AAAAC intron-variant
rs111922578 -- 26,599,881(+) ATTAT(A/G)ATTTC utr-variant-3-prime
rs113057370 -- 26,597,959(+) GGAGG(-/G)AAAAA reference, frameshift-variant
rs113670588 -- 26,598,383(+) CTATC(C/T)TCAAA reference, missense

Variation tolerance for ABT1 Gene

Residual Variation Intolerance Score: 16.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ABT1 Gene

Disorders for ABT1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ABT1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
neuronal intranuclear inclusion disease
  • neuronal intranuclear hyaline inclusion disease
- elite association - COSMIC cancer census association via MalaCards
Search ABT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ABT1

Genetic Association Database (GAD)
ABT1
Human Genome Epidemiology (HuGE) Navigator
ABT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABT1
genes like me logo Genes that share disorders with ABT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ABT1 Gene

Publications for ABT1 Gene

  1. A novel TATA-binding protein-binding protein, ABT1, activates basal transcription and has a yeast homolog that is essential for growth. (PMID: 10648625) Oda T. … Muramatsu M.-A. (Mol. Cell. Biol. 2000) 2 3 4 64
  2. Biochemical and genetic evidence for a role of IGHMBP2 in the translational machinery. (PMID: 19299493) de Planell-Saguer M. … Mourelatos Z. (Hum. Mol. Genet. 2009) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for ABT1 Gene

Sources for ABT1 Gene

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