ABT1 Gene
protein-coding GIFtS: 47
GCID: GC06P026597
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|
activator of basal transcription 1
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Aliases
for ABT1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Activator Of Basal Transcription 11 2 | | Basal Transcriptional Activator2 3 | | HABT11 | | TATA-Binding Protein-Binding Protein2 |
Export aliases for ABT1 gene to outside databasesPrevious GC identifers: GC06P026654 GC06P026705 GC06P026540 |
Summaries
for ABT1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ABT1:
Basal transcription of genes by RNA polymerase II requires the interaction of TATA-binding protein (TBP) with the coreregion of class II promoters. Studies in mouse suggest that the protein encoded by this gene likely activates basaltranscription from class II promoters by interaction with TBP and the class II promoter DNA. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: ABT1_HUMAN, Q9ULW3Function: Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act asa regulator of basal transcription for class II genes (By similarity)
|
Genomic Views
for ABT1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ABT1 gene promoter:
TBP FOXD1 LCR-F1 Evi-1 GATA-2 NRF-2 FOXO1a ATF6 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ABT1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABT1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p22.2 Ensembl cytogenetic band: 6p22.2 HGNC cytogenetic band: 6p21.31ABT1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P026597: view genomic region
(about GC identifiers)
Start:
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26,597,180 bp from pter |
End:
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26,600,278 bp from pter |
Size:
|
3,099 bases |
Orientation:
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plus strand |
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Proteins
for ABT1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ABT1_HUMAN, Q9ULW3 (See
protein sequence)Recommended Name: Activator of basal transcription 1 Size: 272 amino acids; 31079 Da
Subunit: Interacts with ESF1/ABTAP (By similarity). Interacts with IGHMBP2
Subcellular location: Nucleus (By similarity). Nucleus, nucleolus (By similarity)Explore the universe of human proteins at neXtProt for ABT1: NX_Q9ULW3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9ULW3
ABT1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_037507.1
ENSEMBL proteins: ENSP00000274849
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ABT1 for ontologies About GeneDecksing
ABT1 Antibody Products:
Assay Products for ABT1: |
Protein
Domains /
Families
for ABT1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ABT1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9ULW3ProtoNet protein and cluster: Q9ULW3 UniProtKB/Swiss-Prot: ABT1_HUMAN, Q9ULW3Similarity: Belongs to the ESF2/ABP1 familySimilarity: Contains 1 RRM (RNA recognition motif) domain |
Function
for ABT1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ABT1_HUMAN, Q9ULW3Function: Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act asa regulator of basal transcription for class II genes (By similarity)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABT1
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABT1 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
ABT1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ABT1:
|
Pathways & Interactions
for ABT1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ABT1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/31 Interacting proteins for ABT1 (Q9ULW33 ENSP000002748494) via UniProtKB, MINT, STRING, and/or I2D (see all 31)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006357 | regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0006366 | transcription from RNA polymerase II promoter |
IEA | -- | | GO:0021522 | spinal cord motor neuron differentiation |
IEA | -- |
ABT1 for ontologies About GeneDecksing
|
Drugs & Compounds
for ABT1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ABT1 for compounds About GeneDecksing
 Browse Tocris compounds for ABT1
8 Novoseek chemical compound relationships for ABT1 gene About this table
Search CenterWatch for drugs/clinical trials and news about ABT1
|
Transcripts
for ABT1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ABT1 gene: NM_013375.3 Unigene Cluster for ABT1: Activator of basal transcription 1 Hs.254406 [show with all ESTs]Unigene Representative Sequence: NM_0133751 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000274849(uc003nii.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABT1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABT1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ABT1 (NM_013375) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ABT1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABT1 |
Additional cDNA sequence: AB027258.1 BC048812.1 BC066313.1 10 DOTS entries: DT.415322 DT.100806016 DT.40228669 DT.100806004 DT.100806013 DT.121323758 DT.91756269 DT.95211608 DT.121323754 DT.454223 24/261 AceView cDNA sequences (see all 261): CR617743 BU741142 AI240992 AA894779 BE205848 AI925644 BU188987 AI284982 AA907132 BM021996 CR613442 BE328097 AA456757 BU838762 BU179168 CD742569 BM021481 AW273179 BQ436663 BU631741 AW274148 BM758011 BM757998 CR609958
GeneLoc Exon Structure
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Expression
for ABT1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ABT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGTTTTGTG
About this image
See ABT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ABT1
SOURCE GeneReport for Unigene cluster: Hs.254406
SABiosciences Custom PCR Arrays for ABT1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABT1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ABT1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABT1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABT1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABT1 |
Orthologs
for ABT1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ABT1 gene from 9/31 species (see all 31) About this table
ENSEMBL Gene Tree for ABT1 (if available)
TreeFam Gene Tree for ABT1 (if available) |
Paralogs
for ABT1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ABT1 gene
ABT1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ABT1
PGOHUM00000245631
|
Genomic Variants
for ABT1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ABT1 (26597180 - 26600278 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ABT1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABT1 |
|
Disorders
/ Diseases
for ABT1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ABT1 for disorders About GeneDecksing
19  diseases for ABT1: About MalaCardsneuronal intranuclear inclusion disease non-hodgkin lymphoma spinocerebellar ataxia essential thrombocythemia
roberts syndrome systemic lupus erythematosus lupus erythematosus hodgkin's lymphoma
neurodegenerative disease ataxia rabies cholera
t-cell leukemia alzheimer's disease leukemia lung cancer
immunodeficiency neuronitis malaria
1 disease from the University of Copenhagen DISEASES database for ABT1:Roberts syndrome 6 Novoseek disease relationships for ABT1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: ABT1 (1 document)
Export disorders for ABT1 gene to outside databases
|
Publications
for ABT1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ABT1 gene, integrated from 9 sources (see all 194):
(articles sorted by number of sources associating them with ABT1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel TATA-binding protein-binding protein, ABT1, activates basal transcription and has a yeast homolog that is essential for growth. (PubMed id 10648625)1, 2, 3 Oda T.... Muramatsu M.-A. (2000)
- Biochemical and genetic evidence for a role of IGHMBP2 in the translational machinery. (PubMed id 19299493)1, 2 de Planell-Saguer M....Mourelatos Z. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Protein microarray analysis identifies human cellular prion protein interactors. (PubMed id 18482256)1 Satoh J....Tabunoki H. (2009)
- Nucleolar proteome dynamics. (PubMed id 15635413)1 Andersen J.S....Mann M. (2005)
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External Searches for ABT1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ABT1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ABT1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ABT1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ABT1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ABT1 gene:
Search GeneIP for patents involving ABT1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ABT1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ABT1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABT1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABT1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABT1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABT1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABT1 |
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 | | | ABT1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABT1 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABT1 |
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