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Aliases for ABT1 Gene

Aliases for ABT1 Gene

  • Activator Of Basal Transcription 1 2 3
  • Basal Transcriptional Activator 3 4
  • HABT1 3 4
  • TATA-Binding Protein-Binding Protein 3

External Ids for ABT1 Gene

Summaries for ABT1 Gene

Entrez Gene Summary for ABT1 Gene

  • Basal transcription of genes by RNA polymerase II requires the interaction of TATA-binding protein (TBP) with the core region of class II promoters. Studies in mouse suggest that the protein encoded by this gene likely activates basal transcription from class II promoters by interaction with TBP and the class II promoter DNA. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABT1 Gene

ABT1 (Activator Of Basal Transcription 1) is a Protein Coding gene. Diseases associated with ABT1 include roberts syndrome and neuronal intranuclear inclusion disease. GO annotations related to this gene include RNA binding and transcription coactivator activity.

UniProtKB/Swiss-Prot for ABT1 Gene

  • Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABT1 Gene

Genomics for ABT1 Gene

Genomic Location for ABT1 Gene

Start:
26,596,943 bp from pter
End:
26,600,744 bp from pter
Size:
3,802 bases
Orientation:
Plus strand

Genomic View for ABT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABT1 Gene

Regulatory Elements for ABT1 Gene

Proteins for ABT1 Gene

  • Protein details for ABT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULW3-ABT1_HUMAN
    Recommended name:
    Activator of basal transcription 1
    Protein Accession:
    Q9ULW3
    Secondary Accessions:

    Protein attributes for ABT1 Gene

    Size:
    272 amino acids
    Molecular mass:
    31079 Da
    Quaternary structure:
    • Interacts with ESF1/ABTAP (By similarity). Interacts with IGHMBP2.

neXtProt entry for ABT1 Gene

Proteomics data for ABT1 Gene at MOPED

Post-translational modifications for ABT1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys146

Other Protein References for ABT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ABT1 Gene

Domains for ABT1 Gene

Protein Domains for ABT1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ABT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULW3

UniProtKB/Swiss-Prot:

ABT1_HUMAN
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.:
    • Q9ULW3
Family:
  • Belongs to the ESF2/ABP1 family.:
    • Q9ULW3
genes like me logo Genes that share domains with ABT1: view

No data available for Gene Families for ABT1 Gene

Function for ABT1 Gene

Molecular function for ABT1 Gene

UniProtKB/Swiss-Prot Function: Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity).

Gene Ontology (GO) - Molecular Function for ABT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003677 DNA binding IEA --
GO:0003713 transcription coactivator activity TAS 10648625
GO:0005515 protein binding IPI 19299493
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ABT1: view

Phenotypes for ABT1 Gene

genes like me logo Genes that share phenotypes with ABT1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ABT1 Gene

Localization for ABT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABT1 Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABT1 Gene COMPARTMENTS Subcellular localization image for ABT1 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ABT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10648625
GO:0005667 transcription factor complex IEA --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with ABT1: view

Pathways for ABT1 Gene

SuperPathways for ABT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ABT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0021522 spinal cord motor neuron differentiation IEA --
genes like me logo Genes that share ontologies with ABT1: view

No data available for Pathways by source for ABT1 Gene

Compounds for ABT1 Gene

(8) Novoseek inferred chemical compound relationships for ABT1 Gene

Compound -log(P) Hits PubMed IDs
tbps 79.9 1
glutamine 27.6 2
rrna 13.6 1
s-adenosylmethionine 4.88 1
zinc 4.56 1
genes like me logo Genes that share compounds with ABT1: view

Transcripts for ABT1 Gene

mRNA/cDNA for ABT1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(261) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ABT1 Gene

Activator of basal transcription 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABT1 Gene

No ASD Table

Relevant External Links for ABT1 Gene

GeneLoc Exon Structure for
ABT1
ECgene alternative splicing isoforms for
ABT1

Expression for ABT1 Gene

mRNA expression in normal human tissues for ABT1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABT1 Gene

SOURCE GeneReport for Unigene cluster for ABT1 Gene Hs.254406

genes like me logo Genes that share expressions with ABT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ABT1 Gene

Orthologs for ABT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ABT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABT1 35
  • 99.63 (n)
  • 100 (a)
ABT1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ABT1 35
  • 83.21 (n)
  • 83.09 (a)
ABT1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABT1 35
  • 84.8 (n)
  • 88.24 (a)
ABT1 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abt1 35
  • 78.83 (n)
  • 79.47 (a)
Abt1 16
Abt1 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABT1 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABT1 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abt1 35
  • 82.56 (n)
  • 84.11 (a)
lizard
(Anolis carolinensis)
Reptilia ABT1 36
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52939 35
zebrafish
(Danio rerio)
Actinopterygii abt1 35
  • 56.46 (n)
  • 58.37 (a)
abt1 36
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10993 36
  • 27 (a)
OneToMany
CG32706 36
  • 24 (a)
OneToMany
CG32708 36
  • 31 (a)
OneToMany
CG40813 36
  • 28 (a)
OneToMany
CG41562 36
  • 29 (a)
OneToMany
CG6999 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F57B10.8 36
  • 26 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ESF2 36
  • 22 (a)
OneToOne
ESF2 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4929 36
  • 37 (a)
OneToOne
Species with no ortholog for ABT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ABT1 Gene

ENSEMBL:
Gene Tree for ABT1 (if available)
TreeFam:
Gene Tree for ABT1 (if available)

Paralogs for ABT1 Gene

Pseudogenes.org Pseudogenes for ABT1 Gene

genes like me logo Genes that share paralogs with ABT1: view

No data available for Paralogs for ABT1 Gene

Variants for ABT1 Gene

Sequence variations from dbSNP and Humsavar for ABT1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs13227 -- 26,598,936(-) AGTGG(A/G)ATTTT utr-variant-3-prime
rs13978 -- 26,598,815(-) ACAGG(A/C)GTTCG utr-variant-3-prime
rs3800302 -- 26,597,105(+) AAGAA(A/G)CGGGT reference, synonymous-codon
rs3800303 -- 26,597,960(+) GGAGG(A/G)AAAAA reference, synonymous-codon
rs3800304 -- 26,598,570(+) AAAGG(A/G)CTCCT synonymous-codon, reference

Relevant External Links for ABT1 Gene

HapMap Linkage Disequilibrium report
ABT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ABT1 Gene

Disorders for ABT1 Gene

(1) University of Copenhagen DISEASES for ABT1 Gene

(6) Novoseek inferred disease relationships for ABT1 Gene

Disease -log(P) Hits PubMed IDs
sca17 70.1 2
spinocerebellar ataxias 48.8 1
leukemia t-cell 23.7 1
cancer 5.62 1
shock 0 2

Relevant External Links for ABT1

Genetic Association Database (GAD)
ABT1
Human Genome Epidemiology (HuGE) Navigator
ABT1
genes like me logo Genes that share disorders with ABT1: view

No data available for UniProtKB/Swiss-Prot for ABT1 Gene

Publications for ABT1 Gene

  1. A novel TATA-binding protein-binding protein, ABT1, activates basal transcription and has a yeast homolog that is essential for growth. (PMID: 10648625) Oda T. … Muramatsu M.-A. (Mol. Cell. Biol. 2000) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Biochemical and genetic evidence for a role of IGHMBP2 in the translational machinery. (PMID: 19299493) de Planell-Saguer M. … Mourelatos Z. (Hum. Mol. Genet. 2009) 3 4
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for ABT1 Gene

Sources for ABT1 Gene

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