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Aliases for ABRACL Gene

Aliases for ABRACL Gene

  • ABRA C-Terminal Like 2 3 5
  • ABRA C-Terminal-Like Protein 3 4
  • C6orf115 3 4
  • Chromosome 6 Open Reading Frame 115 2
  • Costars Family Protein ABRACL 3
  • Costars 3
  • HSPC280 3
  • PRO2013 3

External Ids for ABRACL Gene

Previous HGNC Symbols for ABRACL Gene

  • C6orf115

Previous GeneCards Identifiers for ABRACL Gene

  • GC06P139349

Summaries for ABRACL Gene

GeneCards Summary for ABRACL Gene

ABRACL (ABRA C-Terminal Like) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABRACL Gene

Genomics for ABRACL Gene

Regulatory Elements for ABRACL Gene

Enhancers for ABRACL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F139027 1.2 FANTOM5 ENCODE 19.1 +0.5 473 3.7 HDGF PKNOX1 WRNIP1 SIN3A GLI4 ZNF2 YY1 GLIS2 ELK1 ZNF263 ABRACL HECA CCDC28A GC06P139052
GH06F139099 0.2 ENCODE 8.7 +71.5 71519 1.1 MTA2 JUNB TBX21 EP300 RELA IKZF1 STAT3 NBN CREM ABRACL HECA GC06P139052
GH06F139080 0.5 ENCODE 7.4 +52.0 52037 0.2 FOS SP7 ABRACL GC06P139052 HECA
GH06F139175 0.4 ENCODE 6.7 +146.9 146911 0.3 CREB3 ZNF316 MTA2 CEBPA IKZF1 MAFK SPI1 HECA REPS1 ABRACL ENSG00000231329
GH06F139131 0.5 ENCODE 6.6 +106.0 105991 5.7 PKNOX1 ATF1 ARID4B SIN3A ZNF48 BRCA1 GLIS2 ZNF143 ZNF207 KLF7 ABRACL HECA TXLNB ECT2L GC06P139052
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ABRACL on UCSC Golden Path with GeneCards custom track

Promoters for ABRACL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001228717 518 3201 HDGF PKNOX1 WRNIP1 SIN3A GLI4 ZNF2 YY1 GLIS2 ELK1 ZNF263

Genomic Location for ABRACL Gene

Chromosome:
6
Start:
139,028,682 bp from pter
End:
139,043,302 bp from pter
Size:
14,621 bases
Orientation:
Plus strand

Genomic View for ABRACL Gene

Genes around ABRACL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABRACL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABRACL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABRACL Gene

Proteins for ABRACL Gene

  • Protein details for ABRACL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1F3-ABRAL_HUMAN
    Recommended name:
    Costars family protein ABRACL
    Protein Accession:
    Q9P1F3
    Secondary Accessions:
    • Q5SZC8
    • Q9P0A1

    Protein attributes for ABRACL Gene

    Size:
    81 amino acids
    Molecular mass:
    9056 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF28958.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ABRACL Gene

neXtProt entry for ABRACL Gene

Post-translational modifications for ABRACL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ABRACL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ABRACL Gene

Domains & Families for ABRACL Gene

Protein Domains for ABRACL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ABRACL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P1F3

UniProtKB/Swiss-Prot:

ABRAL_HUMAN :
  • Belongs to the costars family.
Family:
  • Belongs to the costars family.
genes like me logo Genes that share domains with ABRACL: view

No data available for Gene Families for ABRACL Gene

Function for ABRACL Gene

genes like me logo Genes that share phenotypes with ABRACL: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABRACL Gene

Localization for ABRACL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABRACL Gene COMPARTMENTS Subcellular localization image for ABRACL gene
Compartment Confidence
cytosol 4
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ABRACL Gene

Pathways & Interactions for ABRACL Gene

SuperPathways for ABRACL Gene

No Data Available

Interacting Proteins for ABRACL Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000356632%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000332721%0d%0a
Selected Interacting proteins: ENSP00000356632 Q9P1F3-ABRAL_HUMAN for ABRACL Gene via STRING IID

Gene Ontology (GO) - Biological Process for ABRACL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ABRACL Gene

Transcripts for ABRACL Gene

mRNA/cDNA for ABRACL Gene

Unigene Clusters for ABRACL Gene

ABRA C-terminal like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABRACL Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2: -
SP3:

Relevant External Links for ABRACL Gene

GeneLoc Exon Structure for
ABRACL
ECgene alternative splicing isoforms for
ABRACL

Expression for ABRACL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ABRACL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ABRACL Gene

This gene is overexpressed in NK cells (9.3) and Oral epithelium (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABRACL Gene



Protein tissue co-expression partners for ABRACL Gene

NURSA nuclear receptor signaling pathways regulating expression of ABRACL Gene:

ABRACL

SOURCE GeneReport for Unigene cluster for ABRACL Gene:

Hs.600861
genes like me logo Genes that share expression patterns with ABRACL: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ABRACL Gene

Orthologs for ABRACL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABRACL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABRACL 34 35
  • 99.18 (n)
dog
(Canis familiaris)
Mammalia ABRACL 34 35
  • 91.77 (n)
cow
(Bos Taurus)
Mammalia ABRACL 34 35
  • 90.95 (n)
mouse
(Mus musculus)
Mammalia Abracl 34 16 35
  • 88.48 (n)
rat
(Rattus norvegicus)
Mammalia Abracl 34
  • 87.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ABRACL 35
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABRACL 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves ABRACL 35
  • 84 (a)
OneToOne
C6ORF115 34
  • 80.66 (n)
lizard
(Anolis carolinensis)
Reptilia ABRACL 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abracl 34
  • 79.01 (n)
zebrafish
(Danio rerio)
Actinopterygii abracl 34 35
  • 69.14 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G33640 34
  • 65.38 (n)
rice
(Oryza sativa)
Liliopsida Os03g0690000 34
  • 61.18 (n)
Species where no ortholog for ABRACL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABRACL Gene

ENSEMBL:
Gene Tree for ABRACL (if available)
TreeFam:
Gene Tree for ABRACL (if available)

Paralogs for ABRACL Gene

(1) SIMAP similar genes for ABRACL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ABRACL: view

No data available for Paralogs for ABRACL Gene

Variants for ABRACL Gene

Sequence variations from dbSNP and Humsavar for ABRACL Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10223583 -- 139,031,885(+) CTGCT(C/G)GTGCC intron-variant
rs10457682 -- 139,038,036(+) ccttc(C/G)aaagt intron-variant
rs111254081 -- 139,035,179(+) TTAAT(A/G)TCAAA intron-variant
rs111265728 -- 139,031,351(+) CATCC(C/T)ACCCA intron-variant
rs11155026 -- 139,032,303(+) GCCTC(A/G)TGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABRACL Gene

Variant ID Type Subtype PubMed ID
nsv478447 CNV novel sequence insertion 20440878
nsv510052 OTHER sequence alteration 20534489

Variation tolerance for ABRACL Gene

Residual Variation Intolerance Score: 45% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABRACL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABRACL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABRACL Gene

Disorders for ABRACL Gene

Relevant External Links for ABRACL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABRACL

No disorders were found for ABRACL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABRACL Gene

Publications for ABRACL Gene

  1. Solution structure of the human HSPC280 protein. (PMID: 21082705) Lin J. … Wang J. (Protein Sci. 2011) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4 64
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for ABRACL Gene

Sources for ABRACL Gene

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