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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ABRACL Gene

protein-coding   GIFtS: 34
GCID: GC06P139349

ABRA C-terminal like

(Previous name: chromosome 6 open reading frame 115 )
(Previous symbol: C6orf115)
  Search for ABRACL
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ABRACL    

Aliases
for ABRACL gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ABRA C-Terminal Like1 2     PRO20131 2
C6orf1151 2     ABRA C-Terminal-Like Protein2 3
Costars1 2     Chromosome 6 Open Reading Frame 1151
HSPC2801 2     Costars Family Protein ABRACL2

External Ids:    HGNC: 212301   Entrez Gene: 585272   Ensembl: ENSG000001463867   UniProtKB: Q9P1F33   

Export aliases for ABRACL gene to outside databases


Summaries
for ABRACL gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for ABRACL gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ABRACL
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ABRACL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABRACL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q24.1   Ensembl cytogenetic band:  6q24.1   HGNC cytogenetic band: 6q24.1

ABRACL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABRACL gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P139349:  view genomic region     (about GC identifiers)

Start:
 139,349,819 bp from pter      End:
 139,364,439 bp from pter
Size:
 14,621 bases      Orientation:
 plus strand

Proteins
for ABRACL gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ABRAL_HUMAN, Q9P1F3 (See protein sequence)
Recommended Name: Costars family protein ABRACL  
Size: 81 amino acids; 9056 Da
Sequence caution: Sequence=AAF28958.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for ABRACL:
2L2O (3D)    
Secondary accessions: Q5SZC8 Q9P0A1

Explore the universe of human proteins at neXtProt for ABRACL: NX_Q9P1F3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P1F3

    • ABRACL Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_067066.1  
    ENSEMBL proteins: 
     ENSP00000356632   ENSP00000418406  

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    Protein Domains /
    Families
    for ABRACL gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9P1F3

    UniProtKB/Swiss-Prot: ABRAL_HUMAN, Q9P1F3
    Similarity: Belongs to the costars family


    Function
    for ABRACL gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    1 GenomeRNAi human phenotype for ABRACL:
     Decreased viability with pacli 


    Pathways & Interactions
    for ABRACL gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ABRACL

    Drugs & Compounds
    for ABRACL gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ABRACL
    Search CenterWatch for drugs/clinical trials and news about ABRACL / ABRAL 

    Transcripts
    for ABRACL gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for ABRACL gene: 
    NM_021243.2  

    Unigene Cluster for ABRACL:

    ABRA C-terminal like
    Hs.600861  [show with all ESTs]
    Unigene Representative Sequence: AK309402
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367660(uc003qil.2 uc003qim.2) ENST00000461027

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    Inhib. RNA
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    Additional cDNA sequence: 

    AF116682.1 AF161398.1 AK309402.1 BC014953.1 

    8 DOTS entries:

    DT.443495  DT.91764394  DT.95085153  DT.91764390  DT.91764391  DT.97770375  DT.91764395  DT.95199072 

    24/103 AceView cDNA sequences (see all 103):

    AI868763 BQ015110 AA772331 AW439509 BX110370 AA983471 AV714738 AA287347 
    CK903761 AI151440 AA746935 AI216331 AI469975 CK903760 AV716363 BC014953 
    AW024795 AV717724 BU581717 BG530613 AV716325 BI859694 AF116682 BE891760 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ABRACL    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b
    SP1:                          -               
    SP2:                          -               
    SP3:                                          


    ECgene alternative splicing isoforms for ABRACL

    Expression
    for ABRACL gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ABRACL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAACTGTCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ABRACL expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartAtrioventricular CanalAtrioventricular Canal CellsMyocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ABRACL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ABRACL

    SOURCE GeneReport for Unigene cluster: Hs.600861
        SABiosciences Custom PCR Arrays for ABRACL
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ABRACL

    Orthologs
    for ABRACL gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ABRACL gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Abracl1 , 5 RIKEN cDNA 3110003A17 gene5
    ABRA C-terminal like1    		 88.48(n)1
    92.59(a)1    		   10 (7.39 cM)5
    731121  NM_028440.11  NP_082716.11 
     180112635 
    chicken
    (Gallus gallus)    		 Aves C3H6orf1151 chromosome 3 open reading frame, human C6orf115 80.66(n)
    85.19(a)    		   770205  XM_001233536.2  XP_001233537.2 
    lizard
    (Anolis carolinensis)    		 Reptilia C6orf1156
    		 --
    		 84(a)
    		 1 ↔ 1
    		 GL343200.1(918042-920097)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BX848283.12   -- 80.54(n)    BX848283.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC053269.12   -- 71.89(n)    BC053269.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G336401 hypothetical protein 65.38(n)
    70.51(a)    		   829505  NM_119520.3  NP_567930.1 
    rice
    (Oryza sativa)    		 Liliopsida Os03g06900001 hypothetical protein 61.18(n)
    68.35(a)    		   4333773  NM_001057485.1  NP_001050950.1 


    ENSEMBL Gene Tree for ABRACL (if available)
    TreeFam Gene Tree for ABRACL (if available) 

    Paralogs
    for ABRACL gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for ABRACL gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/323 NCBI SNPs in ABRACL are shown (see all 323)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs24986421,2
    		C,A,H--139347819(+) ctttcC/Tttttt 1 -- us2k1 trp30--------
    rs94030301,2
    		C,F,A,H,--139347894(+) GCTCTC/TGGGTC 1 -- us2k1 tfbs36Minor allele frequency- T:0.18NA WA CSA 11
    rs1401291771,2
    		--139348014(+) AGAGAC/TGGGGT 1 -- us2k10--------
    rs1433015971,2
    		--139348015(+) GAGACA/GGGGTT 1 -- us2k10--------
    rs1851411461,2
    		--139348069(+) GATCCA/GTCCAC 1 -- us2k10--------
    rs1155652591,2
    		F,--139348125(+) CCAGCC/TGACAA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs795222891,2
    		C,--139348214(+) AAGTAT/ACTTTT 1 -- us2k14Minor allele frequency- A:0.11WA NA EA 360
    rs1889196791,2
    		--139348242(+) TATTAA/CCAAGG 1 -- us2k10--------
    rs1816138241,2
    		--139348352(+) ACTCAC/TTATTC 1 -- us2k10--------
    rs753908371,2
    		--139348353(+) CTCATC/TATTCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ABRACL (139349819 - 139364439 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ABRACL: --

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    Disorders / Diseases
    for ABRACL gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for ABRACL gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ABRACL gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ABRACL)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Solution structure of the human HSPC280 protein. (PubMed id 21082705)1, 2, 3 Lin J....Wang J. (2011)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. Costars, a Dictyostelium protein similar to the C-ter minal domain of STARS, regulates the actin cytoskeleton and motility. (PubMed id 20940261)1 Pang T.L....Chen M.Y. (2010)
    7. A proteomic analysis of human hemodialysis fluid. (PubMed id 15723814)1 Molina H....Pandey A. (2005)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    External Searches for ABRACL gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ABRACL gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 58527 HGNC: 21230 AceView: C6orf115 Ensembl:ENSG00000146386 euGenes: HUgn58527
    ECgene: ABRACL H-InvDB: ABRACL

    Other Databases showing ABRACL gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ABRACL gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ABRACL Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ABRACL gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ABRACL gene:
    Search GeneIP for patents involving ABRACL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ABRACL gene

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    About This Section

     
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