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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ABRACL Gene

protein-coding   GIFtS: 34
GCID: GC06P139349

ABRA C-Terminal Like

(Previous name: chromosome 6 open reading frame 115)
(Previous symbol: C6orf115)
  Search for ABRACL
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ABRA C-Terminal Like1 2     Costars2
C6orf1151 2     HSPC2802
ABRA C-Terminal-Like Protein2 3     PRO20132
Chromosome 6 Open Reading Frame 1151     Costars Family Protein ABRACL2

External Ids:    HGNC: 212301   Entrez Gene: 585272   Ensembl: ENSG000001463867   UniProtKB: Q9P1F33   

Export aliases for ABRACL gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ABRACL Gene: 
ABRACL (ABRA C-terminal like) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_025741.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ABRACL
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ABRACL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABRACL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q24.1   Ensembl cytogenetic band:  6q24.1   HGNC cytogenetic band: 6q24.1

ABRACL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABRACL gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P139349:  view genomic region     (about GC identifiers)

Start:
139,349,819 bp from pter      End:
139,364,439 bp from pter
Size:
14,621 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ABRAL_HUMAN, Q9P1F3 (See protein sequence)
Recommended Name: Costars family protein ABRACL  
Size: 81 amino acids; 9056 Da
Sequence caution: Sequence=AAF28958.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for ABRACL:
2L2O (3D)    
Secondary accessions: Q5SZC8 Q9P0A1

Explore the universe of human proteins at neXtProt for ABRACL: NX_Q9P1F3

Explore proteomics data for ABRACL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P1F3

  • ABRACL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ABRACL Protein Expression
    REFSEQ proteins: NP_067066.1  
    ENSEMBL proteins: 
     ENSP00000356632   ENSP00000418406  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9P1F3

    UniProtKB/Swiss-Prot: ABRAL_HUMAN, Q9P1F3
    Similarity: Belongs to the costars family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for ABRACL:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ABRACL 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ABRACL

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ABRACL (ABRAL)

    Search CenterWatch for drugs/clinical trials and news about ABRACL / ABRAL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ABRACL gene: 
    NM_021243.2  

    Unigene Cluster for ABRACL:

    ABRA C-terminal like
    Hs.600861  [show with all ESTs]
    Unigene Representative Sequence: AK309402
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367660(uc003qil.2 uc003qim.2) ENST00000461027
    miRNA
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    Additional mRNA sequence: 

    AF116682.1 AF161398.1 AK309402.1 BC014953.1 

    8 DOTS entries:

    DT.443495  DT.91764394  DT.95085153  DT.91764390  DT.91764391  DT.97770375  DT.91764395  DT.95199072 

    24/103 AceView cDNA sequences (see all 103):

    BX110370 CK903760 AI151440 AW439509 AV714738 AA772331 AI216331 AI469975 
    AA983471 CK903761 AI868763 BQ015110 BC014953 AA287347 AA746935 AV716363 
    BF031281 CB958631 BU849360 BI859694 BQ778215 AV717015 BM542613 BM752941 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ABRACL    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b
    SP1:                          -               
    SP2:                          -               
    SP3:                                          


    ECgene alternative splicing isoforms for ABRACL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ABRACL expression in normal human tissues (normalized intensities)      ABRACL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACTGTCTT
    ABRACL Expression
    About this image


    ABRACL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Thalamus
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Testicular Interstitial Cells Testis Interstitium

    See ABRACL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ABRACL

    SOURCE GeneReport for Unigene cluster: Hs.600861
        SABiosciences Custom PCR Arrays for ABRACL
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABRACL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ABRACL gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Abracl1 , 5 RIKEN cDNA 3110003A17 gene5
    ABRA C-terminal like1
    88.48(n)1
    92.59(a)1
      10 (7.39 cM)5
    731121  NM_028440.11  NP_082716.11 
     180112635 
    chicken
    (Gallus gallus)
    Aves C3H6orf1151 chromosome 3 open reading frame, human C6orf115 80.66(n)
    85.19(a)
      770205  XM_001233536.2  XP_001233537.2 
    lizard
    (Anolis carolinensis)
    Reptilia ABRACL6
    Uncharacterized protein
    84(a)
    1 ↔ 1
    GL343200.1(918042-920097)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX848283.12   -- 80.54(n)    BX848283.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC053269.12   -- 71.89(n)    BC053269.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G336401 hypothetical protein 65.38(n)
    70.51(a)
      829505  NM_119520.3  NP_567930.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g06900001 hypothetical protein 61.18(n)
    68.35(a)
      4333773  NM_001057485.1  NP_001050950.1 


    ENSEMBL Gene Tree for ABRACL (if available)
    TreeFam Gene Tree for ABRACL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ABRACL gene
    1 SIMAP similar gene for ABRACL using alignment to 2 protein entries:     ABRAL_HUMAN (see all proteins):
    ABRA

    ABRACL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/379 SNPs in ABRACL are shown (see all 379)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs601045951,2
    C--136909453(+) TCTTT-/CCTTTTTT 1 -- us2k11Minor allele frequency- CCT:0.00NA 2
    rs24986421,2
    C,A,H--139347819(+) ctttcC/Tttttt 1 -- us2k1 trp30--------
    rs94030301,2
    C,F,A,H--139347894(+) GCTCTC/TGGGTC 1 -- us2k1 tfbs36Minor allele frequency- T:0.18NA WA CSA 11
    rs1401291771,2
    --139348014(+) AGAGAC/TGGGGT 1 -- us2k10--------
    rs1433015971,2
    C--139348015(+) GAGACA/GGGGTT 1 -- us2k10--------
    rs1851411461,2
    C--139348069(+) GATCCA/GTCCAC 1 -- us2k10--------
    rs1155652591,2
    F--139348125(+) CCAGCC/TGACAA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs795222891,2
    C--139348214(+) AAGTAT/ACTTTT 1 -- us2k14Minor allele frequency- A:0.11WA NA EA 360
    rs1889196791,2
    --139348242(+) TATTAA/CCAAGG 1 -- us2k10--------
    rs1816138241,2
    --139348352(+) ACTCAC/TTATTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ABRACL (139349819 - 139364439 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ABRACL: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ABRACL
    DNA2.0 Custom Variant and Variant Library Synthesis for ABRACL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ABRACL gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with ABRACL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Solution structure of the human HSPC280 protein. (PubMed id 21082705)1, 2, 3 Lin J....Wang J. (2011)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. Costars, a Dictyostelium protein similar to the C-ter minal domain of STARS, regulates the actin cytoskeleton and motility. (PubMed id 20940261)1 Pang T.L....Chen M.Y. (2010)
    7. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    8. A proteomic analysis of human hemodialysis fluid. (PubMed id 15723814)1 Molina H....Pandey A. (2005)
    9. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 58527 HGNC: 21230 AceView: C6orf115 Ensembl:ENSG00000146386 euGenes: HUgn58527
    ECgene: ABRACL H-InvDB: ABRACL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ABRACL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ABRACL gene:
    Search GeneIP for patents involving ABRACL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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