Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneAnalytics
- GeneLoc
- GenesLikeMe
- VarElect
- PathCards
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Suite
- Affiliated Databases
  
  Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

ABRA Gene

protein-coding GIFtS: 47
GCID: GC08M107841

Actin-Binding Rho Activating Protein

See ABRA-related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Actin-Binding Rho Activating Protein¹ ²
Striated Muscle Activator Of Rho-Dependent Signaling¹ ² ³
STARS² ³ ⁵
Actin-Binding Rho-Activating Protein²

External Ids:	HGNC: 30655¹	Entrez Gene: 137735²	Ensembl: ENSG00000174429⁷	OMIM: 609747⁵	UniProtKB: Q8N0Z2³

Export aliases for ABRA gene to outside databases

Previous GC identifer: GC08M103092

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ABRA Gene:

ABRA (actin-binding Rho activating protein) is a protein-coding gene. Diseases associated with ABRA include malaria. GO annotations related to this gene include transcription coactivator activity and actin binding.

UniProtKB/Swiss-Prot: ABRA_HUMAN, Q8N0Z2

Function: Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear

translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling (By similarity)

Gene Wiki entry for ABRA Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000008.10 NC_018919.2 NT_008046.17

Regulatory elements:

Regulatory transcription factor binding sites in the ABRA gene promoter:
HFH-3 SRF AML1a SRF (504 AA) FOXO3 FOXO3b PPAR-alpha FOXI1 E2F FOXO3a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ABRA promoter sequence

Search Chromatin IP Primers for ABRA

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ABRA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q23.1 Ensembl cytogenetic band: 8q23.1 HGNC cytogenetic band: 8q23.1

ABRA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABRA gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M107841: view genomic region (about GC identifiers)

Start:	107,771,711 bp from pter	End:	107,782,473 bp from pter
Size:	10,763 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: ABRA_HUMAN, Q8N0Z2 (See protein sequence)

Recommended Name: Actin-binding Rho-activating protein

Size: 381 amino acids; 43117 Da

Subunit: Binds F-actin and ABLIM1, ABLIM2 AND ABLIM3. Interaction with ABLIM2 AND ABLIM3 enhances activity (By

similarity)

Explore the universe of human proteins at neXtProt for ABRA: NX_Q8N0Z2

Explore proteomics data for ABRA at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See ABRA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_631905.1

ENSEMBL proteins:

ENSP00000311436

ABRA Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for ABRA OriGene Protein Over-expression Lysate for ABRA OriGene MassSpec for ABRA OriGene Custom Protein Services for ABRA
	GenScript Custom Purified and Recombinant Proteins Services for ABRA
	Novus Biologicals ABRA Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for ABRA
	Search eBioscience for Proteins for ABRA
	Search GeneTex for Proteins for ABRA
	antibodies-online proteins for ABRA (4 products)
	antibodies-online peptides for ABRA

ABRA Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for ABRA
	Novus Biologicals ABRA Antibodies
	Abcam antibodies for ABRA
	Cloud-Clone Corp. Antibodies for ABRA
	Search ThermoFisher Antibodies for ABRA
	antibodies-online antibodies for ABRA (15 products)

ABRA Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for ABRA
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ABRA
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for ABRA Cloud-Clone Corp. CLIAs for ABRA
	Search eBioscience for ELISAs for ABRA
	antibodies-online kits for ABRA (8 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

2 InterPro protein domains:

IPR026111 Abra/costars

IPR027817 Costars_dom

Graphical View of Domain Structure for InterPro Entry Q8N0Z2

ProtoNet protein and cluster: Q8N0Z2

UniProtKB/Swiss-Prot: ABRA_HUMAN, Q8N0Z2

Domain: The actin-binding domain 1 (ABD1) is intrinsically disordered, and binds to F-actin with higher affinity

than ABD2 (By similarity)

Find genes that share domains with ABRA About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ABRA_HUMAN, Q8N0Z2

Function: Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear

translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling (By similarity)

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003713	transcription coactivator activity	IEA	--
GO:0003779	actin binding	ISS	--

Find genes that share ontologies with ABRA About GenesLikeMe

Phenotypes:
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Abra):

cardiovascular system

homeostasis/metabolism

Find genes that share phenotypes with ABRA About GenesLikeMe

Animal Models:
MGI mouse knock-out Abra^tm1Eno for ABRA

genOway: Develop your customized and physiologically relevant rodent model for ABRA

miRNA Products:		Block miRNA regulation of human, mouse, rat ABRA using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate ABRA (see all 10):
		hsa-miR-4311 hsa-miR-4328 hsa-miR-488 hsa-miR-519e* hsa-miR-33a hsa-miR-515-5p hsa-miR-889 hsa-miR-3119

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for ABRA
		Predesigned siRNA for gene silencing in human, mouse, rat ABRA

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ABRA

Clone Products:		OriGene clones in human, mouse for ABRA (see all 5) OriGene ORF clones in mouse, rat for ABRA OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 7): ABRA (NM_000806)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABRA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABRA

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ABRA
		Browse ESI BIO Cell Lines and PureStem Progenitors for ABRA

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABRA

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

ABRA_HUMAN, Q8N0Z2: Cytoplasm, myofibril, sarcomere (By similarity). Cytoplasm, cytoskeleton (By similarity).

Note=Localized to the I-band of the sarcomere and to a lesser extent to the sarcomeric structure between Z-lines

(By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	4
cytoskeleton	3
nucleus	2

About this image

Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IDA	--
GO:0015629	actin cytoskeleton	ISS	--
GO:0030016	myofibril	--	--
GO:0030017	sarcomere	ISS	--

Find genes that share ontologies with ABRA About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Pathway & Disease-focused RT² Profiler PCR Array including ABRA:

Cardiotoxicity in human mouse rat

Interactions:

GeneGlobe Interaction Network for ABRA

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

Selected Interacting proteins for ABRA (Q8N0Z2³ ENSP00000311436⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACTB	P60709³, ENSP00000349960⁴	I2D: score=1 STRING: ENSP00000349960
ACTC1	P68032³, ENSP00000290378⁴	I2D: score=1 STRING: ENSP00000290378
MYC	P01106³, ENSP00000367207⁴	I2D: score=1 STRING: ENSP00000367207
TANGO2	ENSP00000332721⁴	STRING: ENSP00000332721
SOD1	ENSP00000270142⁴	STRING: ENSP00000270142

About this table

Gene Ontology (GO): Selected biological process terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000060	protein import into nucleus, translocation	IEA	--
GO:0006351	transcription, DNA-templated	IEA	--
GO:0035025	positive regulation of Rho protein signal transduction	ISS	--
GO:0045893	positive regulation of transcription, DNA-templated	--	--
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IEA	--

Find genes that share ontologies with ABRA About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for ABRA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for ABRA gene:

NM_139166.4

Unigene Cluster for ABRA:

Actin-binding Rho activating protein

Hs.374668 [show with all ESTs]

Unigene Representative Sequence: AL832152

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000311955(uc003ymm.4)

miRNA Products:		Block miRNA regulation of human, mouse, rat ABRA using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate ABRA (see all 10):
		hsa-miR-4311 hsa-miR-4328 hsa-miR-488 hsa-miR-519e* hsa-miR-33a hsa-miR-515-5p hsa-miR-889 hsa-miR-3119

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for ABRA
		Predesigned siRNA for gene silencing in human, mouse, rat ABRA

Clone Products:		OriGene clones in human, mouse for ABRA (see all 5) OriGene ORF clones in mouse, rat for ABRA OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 7): ABRA (NM_000806)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABRA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABRA

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for ABRA
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat ABRA
		QuantiTect SYBR Green Assays in human, mouse, rat ABRA
		QuantiFast Probe-based Assays in human, mouse, rat ABRA

Additional mRNA sequence:

AF503617.1 AK056976.1 AK092694.1 AL832152.1 AL833422.1 BC105103.1 BC105105.1

1 DOTS entry:

DT.100018909

16 AceView cDNA sequences:

AF503617 BX500732 AL832152 AK092694 AK056976 AL833422 AX747674 NM_139166

CF552464 CD677000 BF790561 BF670582 AA664594 BF670302 BF576174 BF694393

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ABRA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TAAGATGCAC

About this image

ABRA Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ABRA Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.374668

Pathway & Disease-focused RT² Profiler PCR Array including ABRA:

Cardiotoxicity in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for ABRA
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat ABRA
		QuantiTect SYBR Green Assays in human, mouse, rat ABRA
		QuantiFast Probe-based Assays in human, mouse, rat ABRA

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABRA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ABRA gene from Selected species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Abra^{1 , 5}	actin-binding Rho activating protein^{1, 5}	83.11(n)¹ 80.27(a)¹		15 (16.42 cM)⁵ 223513¹ NM_175456.4¹ NP_780665.1¹ 41865293⁵
chicken (Gallus gallus)	Aves	ABRA¹	actin-binding Rho activating protein	65.25(n) 63.03(a)		430953 XM_428503.4 XP_428503.3
lizard (Anolis carolinensis)	Reptilia	ABRA⁶	actin-binding Rho activating protein	61(a)	1 ↔ 1	4(12002838-12012877)
tropical clawed frog (Xenopus tropicalis)	Amphibia	abra¹	actin-binding Rho activating protein	65.82(n) 64.29(a)		100127806 NM_001113119.1 NP_001106590.1
zebrafish (Danio rerio)	Actinopterygii	abrab¹	actin-binding Rho activating protein b	57.28(n) 55.46(a)		445477 NM_001003986.1 NP_001003986.1
fruit fly (Drosophila melanogaster)	Insecta	CG2113⁶ CG3630⁶	--	28(a) 18(a)	many → 1 many → 1	3L(2995172-2996155) X(2056229-2066314)
worm (Caenorhabditis elegans)	Secernentea	F36F2.1¹	F36F2.1	55.99(n) 55.34(a)		172722 NM_060025.4 NP_492426.1

ENSEMBL Gene Tree for ABRA (if available)
TreeFam Gene Tree for ABRA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for ABRA gene

1 SIMAP similar gene for ABRA using alignment to 1 protein entry: ABRA_HUMAN:

ABRACL

Find genes that share paralogs with ABRA About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78901532^1,2	F	--	107771301(+)	`CACAAG/ACTAGT`	1	--	ds500¹		2		CSA WA	120
rs75534751^1,2	C,F	--	107771345(+)	`CACAAG/AGTGCT`	1	--	ds500¹		1		WA	118
rs145369104^1,2	C	--	107771433(+)	`TCAGA-/AGAGTGT`	1	--	ds500¹		0	--	--	--	--
rs184435956^1,2		--	107771558(+)	`TGAATA/GTGAGG`	1	--	ds500¹		0	--	--	--	--
rs1784476^1,2	C,F,A,H	--	107771680(+)	`ATAACC/TTATAA`	1	--	ds500¹		24		NS EA NA WA CSA	2340
rs188698524^1,2		--	107771726(+)	`CATCTC/TTTATT`	1	--	ut3¹		0	--	--	--	--
rs181134162^1,2		--	107771851(+)	`GGTATA/GGAAAC`	1	--	ut3¹		0	--	--	--	--
rs138911502^1,2	C	--	107771873(+)	`ACTTTA/CTTAAG`	1	--	ut3¹		0	--	--	--	--
rs186253007^1,2		--	107771921(+)	`AAAACA/TAATAT`	1	--	ut3¹		0	--	--	--	--
rs190772473^1,2		--	107772110(+)	`GTCCAA/GTGATT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ABRA (107771711 - 107782473 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for ABRA: About this table

Variant ID	Type	Subtype	PubMed ID
nsv831419	CNV	Loss	17160897

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ABRA

DNA2.0 Custom Variant and Variant Library Synthesis for ABRA

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

OMIM gene information: 609747 OMIM disorders: --

1 disease for ABRA:
About MalaCards

malaria

1 inferred disease relationship from the University of Copenhagen DISEASES database for ABRA:

Cerebral amyloid angiopathy

Find genes that share disorders with ABRA About GenesLikeMe

1 Novoseek inferred disease relationship for ABRA gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
malaria	53.5	3	11489167 (1), 9025691 (1), 8980624 (1)

Genetic Association Database (GAD): ABRA

Export disorders for ABRA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ABRA gene, integrated from 10 sources (see all 27):
(articles sorted by number of sources associating them with ABRA)

STARS, a striated muscle activator of Rho signaling and serum response factor-dependent transcription. (PubMed id 11983702)^{1, 2, 3} Arai A.... Olson E.N. (J. Biol. Chem. 2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Effect of resistance exercise contraction mode and protein supplementation on members of the STARS signalling pathway. (PubMed id 23753523)¹ Vissing K....Russell A. (J. Physiol. (Lond.) 2013)
Genome-wide association scan of dental caries in the permanent dentition. (PubMed id 23259602)¹ Wang X....Marazita M.L. (BMC Oral Health 2012)
Striated muscle activator of Rho signalling (STARS) is a PGC-1I+/oestrogen-related receptor-I+ target gene and is upregulated in human skeletal muscle after endurance exercise. (PubMed id 21486805)¹ Wallace M.A....Russell A.P. (J. Physiol. (Lond.) 2011)
Regulation of STARS and its downstream targets suggest a novel pathway involved in human skeletal muscle hypertrophy and atrophy. (PubMed id 19255118)¹ Lamon S....Russell A.P. (J. Physiol. (Lond.) 2009)
Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity. (PubMed id 17415416)¹ Kuwahara K....Olson E.N. (J. Clin. Invest. 2007)
A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)⁴ Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)⁴ Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 137735	HGNC: 30655	AceView: STARS	Ensembl:ENSG00000174429	euGenes: HUgn137735
ECgene: ABRA	H-InvDB: ABRA

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ABRA	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ABRA gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ABRA gene:
Search GeneIP for patents involving ABRA

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section


	EMD Millipore genomic analysis products

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for ABRA
	Browse OriGene qPCR primer pairs and template standards		OriGene Protein Over-expression Lysate for ABRA
	OriGene MassSpec for ABRA		OriGene clones in human, mouse for ABRA
	OriGene qSTAR qPCR primer pairs in human, mouse for ABRA		OriGene Purified Protein for ABRA
	OriGene ORF clones in mouse, rat for ABRA		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ABRA		OriGene Custom Protein Services for ABRA

	Block miRNA regulation of human, mouse, rat ABRA using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing ABRA
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ABRA		Predesigned siRNA for gene silencing in human, mouse, rat ABRA
	QuantiFast Probe-based Assays in human, mouse, rat ABRA		QuantiTect SYBR Green Assays in human, mouse, rat ABRA
	PCR Arrays including human, mouse, rat ABRA		Search Chromatin IP Primers for ABRA
	Pre-validated RT² qPCR Primer Assay in human, mouse, rat ABRA		GeneGlobe Interaction Network for ABRA
	Regulatory tfbs in ABRA promoter

	GenScript Custom Purified and Recombinant Proteins Services for ABRA		GenScript cDNA clones with any tag delivered in your preferred vector for ABRA
	GenScript Custom Assay Services for ABRA		GenScript Custom overexpressing Cell Line Services for ABRA
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Search Tocris compounds for ABRA

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ABRA antibodies
	ABRA lysates

	Antibodies for ABRA
	See all of Abcam's Antibodies, Kits and Proteins for ABRA
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for ABRA
	Antibodies for ABRA
	ELISAs for ABRA
	CLIAs for ABRA

Browse ESI BIO Cell Lines and PureStem Progenitors for ABRA

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABRA

	Browse SwitchGear 3'UTR luciferase reporter plasmids for ABRA
	SwitchGear Promoter luciferase reporter plasmids for ABRA

Search ThermoFisher Antibodies for ABRA

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABRA

Browse compounds at ApexBio

Search Addgene for plasmids for ABRA

	Search eBioscience for proteins for ABRA
	Search eBioscience for elisas for ABRA
	eBioscience FlowRNA Probe Sets

genOway: Develop your customized and physiologically relevant rodent model for ABRA

	antibodies-online antibodies for ABRA (15 products)
	antibodies-online kits for ABRA (8 products)
	antibodies-online peptides for ABRA
	antibodies-online proteins for ABRA (4 products)

Search GeneTex for proteins for ABRA

GeneCards Home - Full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015 , 3 Feb 2015

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ABRA gene at Home site.

Version: 3.12.352 5 Mar 2015
hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4

GeneCards Suite

Advanced Search

Export list of displayed genes

ABRA Gene

Actin-Binding Rho Activating Protein

Aliases
for ABRA gene

Summaries
for ABRA gene

Genomic Views
for ABRA gene

Proteins
for ABRA gene

ABRA Human Recombinant Protein Products:

ABRA Antibody Products:

ABRA Assay Products:

Domains /
Families
for ABRA gene

Function
for ABRA gene

Localization
for ABRA gene

Pathways & Interactions
for ABRA gene

Drugs & Compounds
for ABRA gene

Transcripts
for ABRA gene

Expression
for ABRA gene

Orthologs
for ABRA gene

Paralogs
for ABRA gene

Genomic Variants
for ABRA gene

Disorders / Diseases
for ABRA gene

Publications
for ABRA gene

External Searches for ABRA gene

Genome Databases showing ABRA gene

Other Databases showing ABRA gene

Specialized Databases showing ABRA gene

Intellectual Property
for ABRA gene

Products
for ABRA gene

View Random Gene

GeneCards Suite

Advanced Search

Export list of displayed genes

ABRA Gene

Actin-Binding Rho Activating Protein

Aliasesfor ABRA gene

Summariesfor ABRA gene

Genomic Viewsfor ABRA gene

Proteinsfor ABRA gene

ABRA Human Recombinant Protein Products:

ABRA Antibody Products:

ABRA Assay Products:

Domains /Familiesfor ABRA gene

Functionfor ABRA gene

Localizationfor ABRA gene

Pathways & Interactionsfor ABRA gene

Drugs & Compoundsfor ABRA gene

Transcriptsfor ABRA gene

Expression for ABRA gene

Orthologsfor ABRA gene

Paralogsfor ABRA gene

Genomic Variantsfor ABRA gene

Disorders / Diseasesfor ABRA gene

Publicationsfor ABRA gene

External Searches for ABRA gene

Genome Databases showing ABRA gene

Other Databases showing ABRA gene

Specialized Databases showing ABRA gene

Intellectual Propertyfor ABRA gene

Productsfor ABRA gene

View Random Gene

Aliases
for ABRA gene

Summaries
for ABRA gene

Genomic Views
for ABRA gene

Proteins
for ABRA gene

Domains /
Families
for ABRA gene

Function
for ABRA gene

Localization
for ABRA gene

Pathways & Interactions
for ABRA gene

Drugs & Compounds
for ABRA gene

Transcripts
for ABRA gene

Expression
for ABRA gene

Orthologs
for ABRA gene

Paralogs
for ABRA gene

Genomic Variants
for ABRA gene

Disorders / Diseases
for ABRA gene

Publications
for ABRA gene

Intellectual Property
for ABRA gene

Products
for ABRA gene