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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ABRA Gene

protein-coding GIFtS: 47
GCID: GC08M107841

Actin-Binding Rho Activating Protein

7 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Actin-Binding Rho Activating Protein¹ ²
Striated Muscle Activator Of Rho-Dependent Signaling¹ ² ³
STARS² ³ ⁵
Actin-Binding Rho-Activating Protein²

External Ids:	HGNC: 30655¹	Entrez Gene: 137735²	Ensembl: ENSG00000174429⁷	OMIM: 609747⁵	UniProtKB: Q8N0Z2³

Export aliases for ABRA gene to outside databases

Previous GC identifer: GC08M103092

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ABRA Gene:

ABRA (actin-binding Rho activating protein) is a protein-coding gene. Diseases associated with ABRA include granulomatous angiitis, and retinal drusen. GO annotations related to this gene include transcription coactivator activity and actin binding.

UniProtKB/Swiss-Prot: ABRA_HUMAN, Q8N0Z2

Function: Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear

translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling (By similarity)

Gene Wiki entry for ABRA Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.2 NT_008046.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ABRA gene promoter:
HFH-3 SRF AML1a SRF (504 AA) FOXO3 FOXO3b PPAR-alpha FOXI1 E2F FOXO3a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ABRA promoter sequence

Search SABiosciences Chromatin IP Primers for ABRA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABRA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q23.1 Ensembl cytogenetic band: 8q23.1 HGNC cytogenetic band: 8q23.1

ABRA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABRA gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M107841: view genomic region (about GC identifiers)

Start:	107,771,711 bp from pter	End:	107,782,473 bp from pter
Size:	10,763 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ABRA_HUMAN, Q8N0Z2 (See protein sequence)

Recommended Name: Actin-binding Rho-activating protein

Size: 381 amino acids; 43117 Da

Subunit: Binds F-actin and ABLIM1, ABLIM2 AND ABLIM3. Interaction with ABLIM2 AND ABLIM3 enhances activity (By

similarity)

Subcellular location: Cytoplasm, myofibril, sarcomere (By similarity). Cytoplasm, cytoskeleton (By similarity).

Note=Localized to the I-band of the sarcomere and to a lesser extent to the sarcomeric structure between Z-lines

(By similarity)

Explore the universe of human proteins at neXtProt for ABRA: NX_Q8N0Z2

Explore proteomics data for ABRA at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q8N0Z2

ABRA Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_631905.1

ENSEMBL proteins:

ENSP00000311436

Human Recombinant Protein Products for ABRA:

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	Novus Biologicals ABRA Lysate
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	Cloud-Clone Corp. Proteins for ABRA

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IDA	--
GO:0015629	actin cytoskeleton	ISS	--
GO:0030016	myofibril	--	--
GO:0030017	sarcomere	ISS	--

ABRA for ontologies About GeneDecksing

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Assay Products for ABRA:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro protein domain:

IPR026111 Abra

Graphical View of Domain Structure for InterPro Entry Q8N0Z2

ProtoNet protein and cluster: Q8N0Z2

UniProtKB/Swiss-Prot: ABRA_HUMAN, Q8N0Z2

Domain: The actin-binding domain 1 (ABD1) is intrinsically disordered, and binds to F-actin with higher affinity

than ABD2 (By similarity)

ABRA for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ABRA_HUMAN, Q8N0Z2

Function: Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear

translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling (By similarity)

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003713	transcription coactivator activity	IEA	--
GO:0003779	actin binding	ISS	--

ABRA for ontologies About GeneDecksing

Phenotypes:
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Abra):

cardiovascular system

homeostasis/metabolism

ABRA for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Abra^tm1Eno for ABRA

inGenious Targeting Laboratory - Custom generated mouse model solutions for ABRA

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ABRA

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ABRA

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ABRA

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ABRA
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate ABRA (see all 10):
		hsa-miR-4311 hsa-miR-4328 hsa-miR-488 hsa-miR-519e* hsa-miR-33a hsa-miR-515-5p hsa-miR-889 hsa-miR-3119

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ABRA
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABRA

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ABRA

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for ABRA (Q8N0Z2³ ENSP00000311436⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACTB	P60709³, ENSP00000349960⁴	I2D: score=1 STRING: ENSP00000349960
ACTC1	P68032³, ENSP00000290378⁴	I2D: score=1 STRING: ENSP00000290378
MYC	P01106³, ENSP00000367207⁴	I2D: score=1 STRING: ENSP00000367207

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000060	protein import into nucleus, translocation	IEA	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0035025	positive regulation of Rho protein signal transduction	ISS	--
GO:0045893	positive regulation of transcription, DNA-dependent	--	--
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IEA	--

ABRA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ABRA

Search CenterWatch for drugs/clinical trials and news about ABRA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ABRA gene:

NM_139166.4

Unigene Cluster for ABRA:

Actin-binding Rho activating protein

Hs.374668 [show with all ESTs]

Unigene Representative Sequence: AL832152

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000311955(uc003ymm.4)

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ABRA
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate ABRA (see all 10):
		hsa-miR-4311 hsa-miR-4328 hsa-miR-488 hsa-miR-519e* hsa-miR-33a hsa-miR-515-5p hsa-miR-889 hsa-miR-3119

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional mRNA sequence:

AF503617.1 AK056976.1 AK092694.1 AL832152.1 AL833422.1 BC105103.1 BC105105.1

1 DOTS entry:

DT.100018909

16 AceView cDNA sequences:

AF503617 BX500732 NM_139166 AL833422 AX747674 AL832152 AK056976 AK092694

BF790561 CF552464 CD677000 BF670302 AA664594 BF670582 BF576174 BF694393

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ABRA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TAAGATGCAC

About this image

See ABRA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ABRA

SOURCE GeneReport for Unigene cluster: Hs.374668

SABiosciences Expression via Pathway-Focused PCR Array including ABRA:

Cardiotoxicity in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABRA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ABRA gene from 6/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Abra^{1 , 5}	actin-binding Rho activating protein^{1, 5}	83.11(n)¹ 80.27(a)¹		15 (16.42 cM)⁵ 223513¹ NM_175456.4¹ NP_780665.1¹ 41865293⁵
chicken (Gallus gallus)	Aves	ABRA¹	actin-binding Rho activating protein	65.25(n) 63.03(a)		430953 XM_428503.3 XP_428503.2
lizard (Anolis carolinensis)	Reptilia	ABRA⁶	Uncharacterized protein	61(a)	1 ↔ 1	4(12002838-12012877)
zebrafish (Danio rerio)	Actinopterygii	abrab¹	actin-binding Rho activating protein b	56.8(n) 54.89(a)		445477 NM_001003986.1 NP_001003986.1
fruit fly (Drosophila melanogaster)	Insecta	CG2113⁶ CG3630⁶	--	26(a) 18(a)	possible ortholog possible ortholog	3L(2995172-2996155) X(2056229-2066314)
worm (Caenorhabditis elegans)	Secernentea	F36F2.1¹	Protein F36F2.1	55.99(n) 55.34(a)		172722 NM_060025.3 NP_492426.1

ENSEMBL Gene Tree for ABRA (if available)
TreeFam Gene Tree for ABRA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ABRA gene

1 SIMAP similar gene for ABRA using alignment to 1 protein entry: ABRA_HUMAN:

ABRACL

ABRA for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78901532^1,2	F	--	107771301(+)	`CACAAG/ACTAGT`	1	--	ds500¹		2		CSA WA	120
rs75534751^1,2	C,F	--	107771345(+)	`CACAAG/AGTGCT`	1	--	ds500¹		1		WA	118
rs145369104^1,2	C	--	107771433(+)	`TCAGA-/AGAGTGT`	1	--	ds500¹		0	--	--	--	--
rs184435956^1,2		--	107771558(+)	`TGAATA/GTGAGG`	1	--	ds500¹		0	--	--	--	--
rs1784476^1,2	C,F,A,H	--	107771680(+)	`ATAACC/TTATAA`	1	--	ds500¹		24		NS EA NA WA CSA	2340
rs188698524^1,2		--	107771726(+)	`CATCTC/TTTATT`	1	--	ut3¹		0	--	--	--	--
rs181134162^1,2		--	107771851(+)	`GGTATA/GGAAAC`	1	--	ut3¹		0	--	--	--	--
rs138911502^1,2	C	--	107771873(+)	`ACTTTA/CTTAAG`	1	--	ut3¹		0	--	--	--	--
rs186253007^1,2		--	107771921(+)	`AAAACA/TAATAT`	1	--	ut3¹		0	--	--	--	--
rs190772473^1,2		--	107772110(+)	`GTCCAA/GTGATT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ABRA (107771711 - 107782473 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for ABRA: About this table

Variant ID	Type	Subtype	PubMed ID
nsv831419	CNV	Loss	17160897

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABRA

DNA2.0 Custom Variant and Variant Library Synthesis for ABRA

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 609747 OMIM disorders: --

7 diseases for ABRA: About MalaCards

granulomatous angiitis retinal drusen mediastinitis cerebral amyloid angiopathy

malaria cerebritis retinitis

1 disease from the University of Copenhagen DISEASES database for ABRA:

Cerebral amyloid angiopathy

ABRA for disorders About GeneDecksing

1 Novoseek inferred disease relationship for ABRA gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
malaria	53.5	3	11489167 (1), 9025691 (1), 8980624 (1)

Genetic Association Database (GAD): ABRA

Export disorders for ABRA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ABRA gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with ABRA)

Utopia: connect your pdf to the dynamic
world of online information

STARS, a striated muscle activator of Rho signaling and serum response factor-dependent transcription. (PubMed id 11983702)^{1, 2, 3} Arai A.... Olson E.N. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Genome-wide association scan of dental caries in the p ermanent dentition. (PubMed id 23259602)¹ Wang X....Marazita M.L. (2012)
Striated muscle activator of Rho signalling (STARS) i s a PGC-1I+/oestrogen-related receptor-I+ target gene and is upregulated in human skeletal muscle after endurance exercise. (PubMed id 21486805)¹ Wallace M.A....Russell A.P. (2011)
Regulation of STARS and its downstream targets suggest a novel pathway involved in human skeletal muscle hypertrophy and atrophy. (PubMed id 19255118)¹ Lamon S....Russell A.P. (2009)
Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity. (PubMed id 17415416)¹ Kuwahara K....Olson E.N. (2007)
A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)⁴ Kathiresan S....Cupples L.A. (2007)
Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)⁴ Fox C.S....Atwood L.D. (2007)
Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)⁴ Benjamin E.J....Vasan R.S. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 137735	HGNC: 30655	AceView: STARS	Ensembl:ENSG00000174429	euGenes: HUgn137735
ECgene: ABRA	H-InvDB: ABRA

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ABRA	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ABRA gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ABRA gene:
Search GeneIP for patents involving ABRA

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for ABRA
	Browse OriGene qPCR primer pairs and template standards		OriGene Protein Over-expression Lysate for ABRA
	OriGene MassSpec something-or-other for ABRA		OriGene clones in human, mouse for ABRA
	OriGene qSTAR qPCR primer pairs in human, mouse for ABRA		OriGene Purified Protein for ABRA
	OriGene ORF clones in mouse, rat for ABRA		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ABRA		OriGene Custom Protein Services for ABRA

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ABRA
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABRA
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABRA
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABRA
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABRA
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	GenScript Custom Purified and Recombinant Proteins Services for ABRA		GenScript cDNA clones with any tag delivered in your preferred vector for ABRA
	GenScript Custom Assay Services for ABRA		GenScript Custom Superior Antibodies Services for ABRA
	GenScript Custom overexpressing Cell Line Services for ABRA		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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	Regulatory tfbs in ABRA promoter
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Search Tocris compounds for ABRA

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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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	Proteins for ABRA
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Search LifeMap BioReagents cell lines for ABRA

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABRA

	Browse SwitchGear 3'UTR luciferase reporter plasmids for ABRA
	SwitchGear Promoter luciferase reporter plasmids for ABRA

Search ThermoFisher Antibodies for ABRA

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABRA

	inGenious Targeting Laboratory - Custom generated mouse model solutions for ABRA
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ABRA

Customized:

	lentivirus for stable overexpression of ABRA
	lentivirus expression plasmids for stable overexpression of ABRA
	adenovirus for overexpression of ABRA

LSBio Antibodies in human, mouse, rat for ABRA

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
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	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ABRA gene at Home site.

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ABRA Gene

Actin-Binding Rho Activating Protein

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Export list of displayed genes

ABRA Gene

Actin-Binding Rho Activating Protein

Aliasesfor ABRA gene

Summariesfor ABRA gene

Genomic Viewsfor ABRA gene

Proteinsfor ABRA gene

Protein Domains /Familiesfor ABRA gene

Functionfor ABRA gene

Pathways & Interactionsfor ABRA gene

Drugs & Compoundsfor ABRA gene

Transcriptsfor ABRA gene

Expression for ABRA gene

Orthologsfor ABRA gene

Paralogsfor ABRA gene

Genomic Variantsfor ABRA gene

Disorders / Diseasesfor ABRA gene

Publicationsfor ABRA gene

External Searches for ABRA gene

Genome Databases showing ABRA gene

Other Databases showing ABRA gene

Specialized Databases showing ABRA gene

Intellectual Propertyfor ABRA gene

Productsfor ABRA gene

View Random Gene

Aliases
for ABRA gene

Summaries
for ABRA gene

Genomic Views
for ABRA gene

Proteins
for ABRA gene

Protein Domains /
Families
for ABRA gene

Function
for ABRA gene

Pathways & Interactions
for ABRA gene

Drugs & Compounds
for ABRA gene

Transcripts
for ABRA gene

Expression
for ABRA gene

Orthologs
for ABRA gene

Paralogs
for ABRA gene

Genomic Variants
for ABRA gene

Disorders / Diseases
for ABRA gene

Publications
for ABRA gene

Intellectual Property
for ABRA gene

Products
for ABRA gene