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Aliases for ABRA Gene

Aliases for ABRA Gene

  • Actin-Binding Rho Activating Protein 2 3
  • Striated Muscle Activator Of Rho-Dependent Signaling 2 3 4
  • STARS 3 4 6
  • Actin-Binding Rho-Activating Protein 3

External Ids for ABRA Gene

Previous GeneCards Identifiers for ABRA Gene

  • GC08M107841
  • GC08M103092

Summaries for ABRA Gene

GeneCards Summary for ABRA Gene

ABRA (Actin-Binding Rho Activating Protein) is a Protein Coding gene. Diseases associated with ABRA include malaria. GO annotations related to this gene include actin binding and transcription coactivator activity.

UniProtKB/Swiss-Prot for ABRA Gene

  • Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling.

Gene Wiki entry for ABRA Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABRA Gene

Genomics for ABRA Gene

Regulatory Elements for ABRA Gene

Genomic Location for ABRA Gene

Start:
106,759,483 bp from pter
End:
106,770,245 bp from pter
Size:
10,763 bases
Orientation:
Minus strand

Genomic View for ABRA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABRA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABRA Gene

Proteins for ABRA Gene

  • Protein details for ABRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0Z2-ABRA_HUMAN
    Recommended name:
    Actin-binding Rho-activating protein
    Protein Accession:
    Q8N0Z2
    Secondary Accessions:

    Protein attributes for ABRA Gene

    Size:
    381 amino acids
    Molecular mass:
    43117 Da
    Quaternary structure:
    • Binds F-actin and ABLIM1, ABLIM2 AND ABLIM3. Interaction with ABLIM2 AND ABLIM3 enhances activity (By similarity).

neXtProt entry for ABRA Gene

Proteomics data for ABRA Gene at MOPED

Post-translational modifications for ABRA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ABRA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ABRA Gene

Domains for ABRA Gene

Protein Domains for ABRA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ABRA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N0Z2

UniProtKB/Swiss-Prot:

ABRA_HUMAN :
  • Q8N0Z2
Domain:
  • The actin-binding domain 1 (ABD1) is intrinsically disordered, and binds to F-actin with higher affinity than ABD2.
genes like me logo Genes that share domains with ABRA: view

No data available for Gene Families for ABRA Gene

Function for ABRA Gene

Molecular function for ABRA Gene

UniProtKB/Swiss-Prot Function: Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling.

Gene Ontology (GO) - Molecular Function for ABRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IEA --
GO:0003779 actin binding ISS --
genes like me logo Genes that share ontologies with ABRA: view

Phenotypes for ABRA Gene

genes like me logo Genes that share phenotypes with ABRA: view

Animal Models for ABRA Gene

MGI Knock Outs for ABRA:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ABRA Gene

Localization for ABRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABRA Gene

Cytoplasm, myofibril, sarcomere. Cytoplasm, cytoskeleton. Note=Localized to the I-band of the sarcomere and to a lesser extent to the sarcomeric structure between Z-lines. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABRA Gene COMPARTMENTS Subcellular localization image for ABRA gene
Compartment Confidence
plasma membrane 4
cytoskeleton 3
nucleus 2

Gene Ontology (GO) - Cellular Components for ABRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
GO:0015629 actin cytoskeleton ISS --
GO:0030016 myofibril --
GO:0030017 sarcomere ISS --
genes like me logo Genes that share ontologies with ABRA: view

Pathways for ABRA Gene

SuperPathways for ABRA Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ABRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0035025 positive regulation of Rho protein signal transduction ISS --
GO:0045893 positive regulation of transcription, DNA-templated --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ABRA: view

No data available for Pathways by source for ABRA Gene

Transcripts for ABRA Gene

mRNA/cDNA for ABRA Gene

(7) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ABRA Gene

Actin-binding Rho activating protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABRA

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ABRA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABRA Gene

No ASD Table

Relevant External Links for ABRA Gene

GeneLoc Exon Structure for
ABRA
ECgene alternative splicing isoforms for
ABRA

Expression for ABRA Gene

mRNA expression in normal human tissues for ABRA Gene

mRNA differential expression in normal tissues according to GTEx for ABRA Gene

This gene is overexpressed in Muscle - Skeletal (30.2), Heart - Atrial Appendage (9.7), and Heart - Left Ventricle (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ABRA Gene

SOURCE GeneReport for Unigene cluster for ABRA Gene Hs.374668

genes like me logo Genes that share expressions with ABRA: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ABRA Gene

Orthologs for ABRA Gene

This gene was present in the common ancestor of animals.

Orthologs for ABRA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABRA 35
  • 99.39 (n)
  • 98.69 (a)
ABRA 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ABRA 35
  • 84.6 (n)
  • 81.36 (a)
ABRA 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABRA 35
  • 86.23 (n)
  • 84.74 (a)
ABRA 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abra 35
  • 83.11 (n)
  • 80.27 (a)
Abra 16
Abra 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 49 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ABRA 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abra 35
  • 82.58 (n)
  • 78.93 (a)
chicken
(Gallus gallus)
Aves ABRA 35
  • 65.25 (n)
  • 63.03 (a)
ABRA 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABRA 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abra 35
  • 65.82 (n)
  • 64.29 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14076 35
zebrafish
(Danio rerio)
Actinopterygii abrab 35
  • 57.28 (n)
  • 55.46 (a)
abrab 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2113 36
  • 28 (a)
OneToMany
CG3630 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F36F2.1 35
  • 55.99 (n)
  • 55.34 (a)
F36F2.1 36
  • 37 (a)
OneToMany
tag-243 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for ABRA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABRA Gene

ENSEMBL:
Gene Tree for ABRA (if available)
TreeFam:
Gene Tree for ABRA (if available)

Paralogs for ABRA Gene

Selected SIMAP similar genes for ABRA Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ABRA: view

No data available for Paralogs for ABRA Gene

Variants for ABRA Gene

Sequence variations from dbSNP and Humsavar for ABRA Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1542644 -- 106,760,163(+) TGTAA(A/T)GAAAC utr-variant-3-prime
rs1552302 -- 106,762,844(+) TCTCT(A/G)TCTCC intron-variant
rs1681879 -- 106,767,215(+) GACAA(A/G)TGCCA intron-variant
rs1784475 -- 106,759,243(+) AGGCC(G/T)TTTAC downstream-variant-500B
rs1784476 -- 106,759,452(+) ATAAC(C/T)TATAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ABRA Gene

Variant ID Type Subtype PubMed ID
nsv831419 CNV Loss 17160897

Relevant External Links for ABRA Gene

HapMap Linkage Disequilibrium report
ABRA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABRA Gene

Disorders for ABRA Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ABRA Gene including...

Search for ABRA Gene in MalaCards »

(1) University of Copenhagen DISEASES for ABRA Gene

(1) Novoseek inferred disease relationships for ABRA Gene

Disease -log(P) Hits PubMed IDs
malaria 53.5 3

Relevant External Links for ABRA

Genetic Association Database (GAD)
ABRA
genes like me logo Genes that share disorders with ABRA: view

No data available for UniProtKB/Swiss-Prot for ABRA Gene

Publications for ABRA Gene

  1. STARS, a striated muscle activator of Rho signaling and serum response factor-dependent transcription. (PMID: 11983702) Arai A. … Olson E.N. (J. Biol. Chem. 2002) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  5. Muscle-specific signaling mechanism that links actin dynamics to serum response factor. (PMID: 15798203) Kuwahara K. … Olson E.N. (Mol. Cell. Biol. 2005) 3

Products for ABRA Gene

Sources for ABRA Gene

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