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ABRA Gene(Protein Coding)

Actin Binding Rho Activating Protein

GCID:
GC08M106759
GIFtS:
47
Genes Participants
UDN Logo

Aliases for ABRA Gene

Aliases for ABRA Gene

  • Actin Binding Rho Activating Protein 2 3 5
  • Striated Muscle Activator Of Rho-Dependent Signaling 2 3 4
  • STARS 3 4
  • Actin-Binding Rho-Activating Protein 3

External Ids for ABRA Gene

Previous GeneCards Identifiers for ABRA Gene

  • GC08M107841
  • GC08M103092

Summaries for ABRA Gene

GeneCards Summary for ABRA Gene

ABRA (Actin Binding Rho Activating Protein) is a Protein Coding gene. Diseases associated with ABRA include Malaria and Granulomatous Angiitis. GO annotations related to this gene include actin binding and transcription coactivator activity.

UniProtKB/Swiss-Prot for ABRA Gene

  • Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling.

Gene Wiki entry for ABRA Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABRA Gene

Genomics for ABRA Gene

Products:

  1. Regulatory Element

Regulatory Elements for ABRA Gene

Enhancers for ABRA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G106772 1 Ensembl ENCODE dbSUPER 0.7 -2.8 -2824 0.8 GATA3 RFX1 POLR2A GATA2 SMARCA4 OXR1 ABRA ENSG00000275905
GH08G106765 0.9 Ensembl dbSUPER 0.7 +4.8 4751 0.6 CTCF ZNF654 MNT REST EP300 RAD21 CTBP1 TARDBP ZNF143 SMC3 ABRA RNU7-84P
GH08G106762 1.5 FANTOM5 Ensembl ENCODE dbSUPER 0.4 +7.0 6972 0.7 TBP CTCF MAX CEBPG RAD21 TEAD3 SCRT2 SMC3 ZNF654 TEAD1 ABRA RNU7-84P
GH08G106768 0.8 ENCODE dbSUPER 0.7 +0.4 446 2.6 POLR2H CTCF ZNF654 SMC3 CREB1 MNT RAD21 OXR1 ABRA RNU7-84P
GH08G106778 0.9 ENCODE dbSUPER 0.4 -8.4 -8403 0.2 ESRRA MNT DPF2 JUND GATA3 CTBP1 FOS FOSL2 ABRA ENSG00000275905
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ABRA on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ABRA gene promoter:

Genomic Location for ABRA Gene

Chromosome:
8
Start:
106,759,483 bp from pter
End:
106,770,245 bp from pter
Size:
10,763 bases
Orientation:
Minus strand

Genomic View for ABRA Gene

Genes around ABRA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABRA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABRA Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ABRA Gene

Proteins for ABRA Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ABRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0Z2-ABRA_HUMAN
    Recommended name:
    Actin-binding Rho-activating protein
    Protein Accession:
    Q8N0Z2

    Protein attributes for ABRA Gene

    Size:
    381 amino acids
    Molecular mass:
    43117 Da
    Quaternary structure:
    • Binds F-actin and ABLIM1, ABLIM2 AND ABLIM3. Interaction with ABLIM2 AND ABLIM3 enhances activity (By similarity).

neXtProt entry for ABRA Gene

Protein Expression for ABRA Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ABRA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ABRA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ABRA

No data available for DME Specific Peptides for ABRA Gene

Domains & Families for ABRA Gene

Protein Domains for ABRA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ABRA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N0Z2

UniProtKB/Swiss-Prot:

ABRA_HUMAN :
  • The actin-binding domain 1 (ABD1) is intrinsically disordered, and binds to F-actin with higher affinity than ABD2.
Domain:
  • The actin-binding domain 1 (ABD1) is intrinsically disordered, and binds to F-actin with higher affinity than ABD2.
genes like me logo Genes that share domains with ABRA: view

No data available for Gene Families for ABRA Gene

Function for ABRA Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for ABRA Gene

UniProtKB/Swiss-Prot Function:
Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling.

Gene Ontology (GO) - Molecular Function for ABRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding ISS --
genes like me logo Genes that share ontologies with ABRA: view
genes like me logo Genes that share phenotypes with ABRA: view

Animal Models for ABRA Gene

MGI Knock Outs for ABRA:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ABRA Gene

Localization for ABRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABRA Gene

Cytoplasm, myofibril, sarcomere. Cytoplasm, cytoskeleton. Note=Localized to the I-band of the sarcomere and to a lesser extent to the sarcomeric structure between Z-lines. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABRA gene
Compartment Confidence
plasma membrane 4
cytoskeleton 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ABRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IDA --
GO:0015629 actin cytoskeleton IEA,ISS --
GO:0030016 myofibril IEA --
genes like me logo Genes that share ontologies with ABRA: view

Pathways & Interactions for ABRA Gene

SuperPathways for ABRA Gene

PathCards logo More details on SuperPathways for ABRA
No Data Available

Gene Ontology (GO) - Biological Process for ABRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with ABRA: view

No data available for Pathways by source and SIGNOR curated interactions for ABRA Gene

Drugs & Compounds for ABRA Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ABRA Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ABRA Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ABRA Gene

Actin-binding Rho activating protein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABRA Gene

No ASD Table

Relevant External Links for ABRA Gene

GeneLoc Exon Structure for
ABRA
ECgene alternative splicing isoforms for
ABRA

Expression for ABRA Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ABRA Gene

mRNA expression in normal human tissues for ABRA Gene
mRNA expression by BioGPS for ABRA GenemRNA expression by GTEx for ABRA Gene

mRNA differential expression in normal tissues according to GTEx for ABRA Gene

This gene is overexpressed in Muscle - Skeletal (x30.2), Heart - Atrial Appendage (x9.7), and Heart - Left Ventricle (x7.6).

Protein differential expression in normal tissues from HIPED for ABRA Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ABRA Gene



Protein tissue co-expression partners for ABRA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ABRA Gene:

ABRA

SOURCE GeneReport for Unigene cluster for ABRA Gene:

Hs.374668

Evidence on tissue expression from TISSUES for ABRA Gene

  • Heart(4.3)
  • Muscle(3.2)
genes like me logo Genes that share expression patterns with ABRA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABRA Gene

Orthologs for ABRA Gene

This gene was present in the common ancestor of animals.

Orthologs for ABRA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ABRA 34 35
  • 99.39 (n)
dog
(Canis familiaris)
 Mammalia ABRA 34 35
  • 86.23 (n)
cow
(Bos Taurus)
 Mammalia ABRA 34 35
  • 84.6 (n)
mouse
(Mus musculus)
 Mammalia Abra 34 16 35
  • 83.11 (n)
rat
(Rattus norvegicus)
 Mammalia Abra 34
  • 82.58 (n)
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 72 (a)
 OneToMany
-- 35
  • 49 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia ABRA 35
  • 65 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves ABRA 34 35
  • 65.25 (n)
lizard
(Anolis carolinensis)
 Reptilia ABRA 35
  • 61 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia abra 34
  • 65.82 (n)
zebrafish
(Danio rerio)
 Actinopterygii abrab 34 35
  • 57.28 (n)
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.14076 34
fruit fly
(Drosophila melanogaster)
 Insecta CG2113 35
  • 28 (a)
 OneToMany
CG3630 35
  • 18 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea F36F2.1 34 35
  • 55.99 (n)
tag-243 35
  • 24 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 43 (a)
 OneToOne
Species where no ortholog for ABRA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABRA Gene

ENSEMBL:
Gene Tree for ABRA (if available)
TreeFam:
Gene Tree for ABRA (if available)

Paralogs for ABRA Gene

(1) SIMAP similar genes for ABRA Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ABRA: view

No data available for Paralogs for ABRA Gene

Variants for ABRA Gene

Sequence variations from dbSNP and Humsavar for ABRA Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000096862 -- 106,771,002(+) ATTGG(A/G)TTTTA upstream-variant-2KB
rs1000521681 -- 106,760,757(+) AGAGA(A/C)TCTGT utr-variant-3-prime
rs1000727099 -- 106,772,109(+) AAAGG(C/T)ATAAA upstream-variant-2KB
rs1000851991 -- 106,765,053(+) TGATA(A/C)TTTAG intron-variant
rs1001212417 -- 106,771,895(+) GACTG(G/T)AAAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ABRA Gene

Variant ID Type Subtype PubMed ID
nsv1032991 CNV gain 25217958
nsv611846 CNV loss 21841781
nsv831419 CNV loss 17160897

Variation tolerance for ABRA Gene

Residual Variation Intolerance Score: 24.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABRA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABRA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABRA Gene

Disorders for ABRA Gene

MalaCards: The human disease database

(2) MalaCards diseases for ABRA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
malaria
  • malaria, severe
granulomatous angiitis
  • vasculitis, central nervous system
- elite association - COSMIC cancer census association via MalaCards
Search ABRA in MalaCards View complete list of genes associated with diseases

Relevant External Links for ABRA

Genetic Association Database (GAD)
ABRA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABRA
genes like me logo Genes that share disorders with ABRA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ABRA Gene

Publications for ABRA Gene

  1. STARS, a striated muscle activator of Rho signaling and serum response factor-dependent transcription. (PMID: 11983702) Arai A. … Olson E.N. (J. Biol. Chem. 2002) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Effect of resistance exercise contraction mode and protein supplementation on members of the STARS signalling pathway. (PMID: 23753523) Vissing K. … Russell A. (J. Physiol. (Lond.) 2013) 3 64
  5. Genome-wide association scan of dental caries in the permanent dentition. (PMID: 23259602) Wang X. … Marazita M.L. (BMC Oral Health 2012) 3 64

Products for ABRA Gene

Sources for ABRA Gene

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