ABRA Gene
protein-coding GIFtS: 46
GCID: GC08M107841
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actin-binding Rho activating protein
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Aliases
for ABRA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Actin-Binding Rho Activating Protein1 2 | | STARS1 2 3 5 | | Striated Muscle Activator Of Rho-Dependent Signaling2 3 | | Actin-Binding Rho-Activating Protein2 |
Export aliases for ABRA gene to outside databasesPrevious GC identifer: GC08M103092 |
Summaries
for ABRA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ABRA_HUMAN, Q8N0Z2Function: Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nucleartranslocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling (By similarity)
Gene Wiki entry for ABRA
|
Genomic Views
for ABRA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ABRA gene promoter:
HFH-3 SRF AML1a SRF (504 AA) FOXO3 FOXO3b PPAR-alpha FOXI1 E2F FOXO3a
Other transcription factors
Search SABiosciences Chromatin IP Primers for ABRA
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABRA |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q23.1 Ensembl cytogenetic band: 8q23.1 HGNC cytogenetic band: 8q23.1ABRA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M107841: view genomic region
(about GC identifiers)
Start:
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107,771,711 bp from pter |
End:
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107,782,473 bp from pter |
Size:
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10,763 bases |
Orientation:
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minus strand |
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Proteins
for ABRA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ABRA_HUMAN, Q8N0Z2 (See
protein sequence)Recommended Name: Actin-binding Rho-activating protein Size: 381 amino acids; 43117 Da
Subunit: Binds F-actin and ABLIM1, ABLIM2 AND ABLIM3. Interaction with ABLIM2 AND ABLIM3 enhances activity (Bysimilarity)
Subcellular location: Cytoplasm, myofibril, sarcomere (By similarity). Cytoplasm, cytoskeleton (By similarity).Note=Localized to the I-band of the sarcomere and to a lesser extent to the sarcomeric structure between Z-lines (Bysimilarity)Explore the universe of human proteins at neXtProt for ABRA: NX_Q8N0Z2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N0Z2
ABRA Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_631905.1
ENSEMBL proteins: ENSP00000311436
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
ABRA for ontologies About GeneDecksing
ABRA Antibody Products:
Assay Products for ABRA: |
Protein
Domains /
Families
for ABRA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ABRA for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8N0Z2ProtoNet protein and cluster: Q8N0Z2 UniProtKB/Swiss-Prot: ABRA_HUMAN, Q8N0Z2Domain: The actin-binding domain 1 (ABD1) is intrinsically disordered, and binds to F-actin with higher affinity thanABD2 (By similarity) |
Function
for ABRA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ABRA_HUMAN, Q8N0Z2Function: Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nucleartranslocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABRA (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABRA
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ABRA | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABRA |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABRA |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003713 | transcription coactivator activity |
IEA | -- | | GO:0003779 | actin binding |
ISS | -- |
ABRA for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Abratm1Eno for ABRA
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Abra):
ABRA for phenotypes About GeneDecksing
|
Pathways & Interactions
for ABRA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ABRA
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for ABRA (Q8N0Z23 ENSP000003114364) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000060 | protein import into nucleus, translocation |
IEA | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0035025 | positive regulation of Rho protein signal transduction |
ISS | -- | | GO:0045893 | positive regulation of transcription, DNA-dependent |
-- | -- | | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter |
IEA | -- |
ABRA for ontologies About GeneDecksing
|
Drugs & Compounds
for ABRA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ABRA
Search CenterWatch for drugs/clinical trials and news about ABRA
|
Transcripts
for ABRA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ABRA gene: NM_139166.4 Unigene Cluster for ABRA: Actin-binding Rho activating protein Hs.374668 [show with all ESTs]Unigene Representative Sequence: AL8321521 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000311955(uc003ymm.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABRA (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABRA
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 7): ABRA (NM_000806) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ABRA | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABRA |
Additional cDNA sequence: AF503617.1 AK056976.1 AK092694.1 AL832152.1 AL833422.1 BC105103.1 BC105105.1 1 DOTS entry: DT.100018909 16 AceView cDNA sequences: AF503617 BX500732 AK056976 NM_139166 AX747674 AL832152 AK092694 AL833422 CF552464 CD677000 BF790561 BF670582 BF670302 AA664594 BF694393 BF576174
GeneLoc Exon Structure
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Expression
for ABRA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ABRA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAGATGCAC
About this image
See ABRA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ABRA
SOURCE GeneReport for Unigene cluster: Hs.374668
SABiosciences Expression via Pathway-Focused PCR Array including ABRA:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABRA
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ABRA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABRA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABRA | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABRA |
Orthologs
for ABRA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ABRA gene from 6/16 species (see all 16) About this table
ENSEMBL Gene Tree for ABRA (if available)
TreeFam Gene Tree for ABRA (if available) |
Paralogs
for ABRA gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ABRA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ABRA (107771711 - 107782473 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ABRA: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABRA |
|
Disorders
/ Diseases
for ABRA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ABRA for disorders About GeneDecksing
OMIM gene information: 609747
OMIM disorders: --
7  diseases for ABRA: About MalaCardsgranulomatous angiitis cerebral amyloid angiopathy retinal drusen mediastinitis
malaria cerebritis retinitis
2 diseases from the University of Copenhagen DISEASES database for ABRA:Retinal drusen Cerebral amyloid angiopathy 1 Novoseek disease relationship for ABRA gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| malaria |
53.5 |
3 |
11489167 (1), 9025691 (1), 8980624 (1) |
Export disorders for ABRA gene to outside databases
|
Publications
for ABRA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ABRA gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with ABRA) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- STARS, a striated muscle activator of Rho signaling and serum response factor-dependent transcription. (PubMed id 11983702)1, 2, 3 Arai A.... Olson E.N. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Striated muscle activator of Rho signalling (STARS) i s a PGC-1I+/oestrogen-related receptor-I+ target gene and is upregulated in human skeletal muscle after endurance exercise. (PubMed id 21486805)1 Wallace M.A....Russell A.P. (2011)
- Regulation of STARS and its downstream targets suggest a novel pathway involved in human skeletal muscle hypertrophy and atrophy. (PubMed id 19255118)1 Lamon S....Russell A.P. (2009)
- Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity. (PubMed id 17415416)1 Kuwahara K....Olson E.N. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Muscle-specific signaling mechanism that links actin dynamics to serum response factor. (PubMed id 15798203)1 Kuwahara K....Olson E.N. (2005)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
|
External Searches for ABRA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ABRA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ABRA gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ABRA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ABRA | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ABRA gene:
Search GeneIP for patents involving ABRA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ABRA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ABRA | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABRA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABRA | | | OriGene Protein Over-expression Lysate for ABRA | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ABRA | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABRA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABRA | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ABRA | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ABRA | | OriGene Custom Protein Services for ABRA | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ABRA | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABRA | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABRA | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABRA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABRA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABRA |
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 |  |  |  | |
| | | | Search Tocris compounds for ABRA |
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 | | | ABRA Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABRA |
|  |  |  | | | | Search ThermoFisher Antibodies for ABRA |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABRA |
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