External Ids for ABR Gene
Previous GeneCards Identifiers for ABR Gene
This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012]
GeneCards Summary for ABR Gene
ABR (Active BCR-Related) is a Protein Coding gene. Diseases associated with ABR include retroperitoneal neuroblastoma and chronic wasting disease. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include GTPase activator activity and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is SYDE1.
UniProtKB/Swiss-Prot for ABR Gene
GTPase-activating protein for RAC and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them