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Aliases for ABLIM3 Gene

Aliases for ABLIM3 Gene

  • Actin Binding LIM Protein Family Member 3 2 3 5
  • Actin Binding LIM Protein Family, Member 3 2 3
  • Actin-Binding LIM Protein Family Member 3 3 4
  • AbLIM-3 3 4
  • HMFN1661 3
  • KIAA0843 4

External Ids for ABLIM3 Gene

Previous GeneCards Identifiers for ABLIM3 Gene

  • GC05P148549
  • GC05P148501
  • GC05P143667

Summaries for ABLIM3 Gene

Entrez Gene Summary for ABLIM3 Gene

  • The LIM domain is a double zinc finger structure that promotes protein-protein interactions. LIM domain proteins, such as ABLIM3, play roles in embryonic development, cell lineage determination, and cancer (Krupp et al., 2006 [PubMed 16328021]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ABLIM3 Gene

ABLIM3 (Actin Binding LIM Protein Family Member 3) is a Protein Coding gene. Among its related pathways are Axon guidance and Developmental Biology. GO annotations related to this gene include actin binding. An important paralog of this gene is AJUBA.

UniProtKB/Swiss-Prot for ABLIM3 Gene

  • May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.

Gene Wiki entry for ABLIM3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABLIM3 Gene

Genomics for ABLIM3 Gene

Regulatory Elements for ABLIM3 Gene

Enhancers for ABLIM3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ABLIM3 on UCSC Golden Path with GeneCards custom track

Promoters for ABLIM3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ABLIM3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ABLIM3 Gene

149,141,483 bp from pter
149,260,542 bp from pter
119,060 bases
Plus strand

Genomic View for ABLIM3 Gene

Genes around ABLIM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABLIM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABLIM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABLIM3 Gene

Proteins for ABLIM3 Gene

  • Protein details for ABLIM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Actin-binding LIM protein 3
    Protein Accession:
    Secondary Accessions:
    • A8K121
    • Q19VH3
    • Q658S1
    • Q68CI5
    • Q9BV32

    Protein attributes for ABLIM3 Gene

    683 amino acids
    Molecular mass:
    77802 Da
    Quaternary structure:
    • Directly interacts with F-actin and ABRA.
    • Sequence=BAA74866.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ABLIM3 Gene

    Alternative splice isoforms for ABLIM3 Gene


neXtProt entry for ABLIM3 Gene

Proteomics data for ABLIM3 Gene at MOPED

Post-translational modifications for ABLIM3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ABLIM3 Gene

Domains & Families for ABLIM3 Gene

Gene Families for ABLIM3 Gene

Protein Domains for ABLIM3 Gene

Suggested Antigen Peptide Sequences for ABLIM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 HP (headpiece) domain.
  • Contains 1 HP (headpiece) domain.
  • Contains 4 LIM zinc-binding domains.
genes like me logo Genes that share domains with ABLIM3: view

Function for ABLIM3 Gene

Molecular function for ABLIM3 Gene

UniProtKB/Swiss-Prot Function:
May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.

Gene Ontology (GO) - Molecular Function for ABLIM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with ABLIM3: view
genes like me logo Genes that share phenotypes with ABLIM3: view

Animal Model Products

miRNA for ABLIM3 Gene

miRTarBase miRNAs that target ABLIM3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABLIM3 Gene

Localization for ABLIM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABLIM3 Gene


Subcellular locations from

Jensen Localization Image for ABLIM3 Gene COMPARTMENTS Subcellular localization image for ABLIM3 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for ABLIM3 Gene

Pathways & Interactions for ABLIM3 Gene

genes like me logo Genes that share pathways with ABLIM3: view

Pathways by source for ABLIM3 Gene

1 KEGG pathway for ABLIM3 Gene
1 Qiagen pathway for ABLIM3 Gene

Gene Ontology (GO) - Biological Process for ABLIM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030032 lamellipodium assembly IMP 22684256
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ABLIM3: view

No data available for SIGNOR curated interactions for ABLIM3 Gene

Drugs & Compounds for ABLIM3 Gene

No Compound Related Data Available

Transcripts for ABLIM3 Gene

mRNA/cDNA for ABLIM3 Gene

(11) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ABLIM3 Gene

Actin binding LIM protein family, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABLIM3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^
SP1: - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP5: - - -

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
SP2: -

Relevant External Links for ABLIM3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ABLIM3 Gene

mRNA expression in normal human tissues for ABLIM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABLIM3 Gene

This gene is overexpressed in Liver (x4.9).

Protein differential expression in normal tissues from HIPED for ABLIM3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.8), Liver (10.3), and Heart (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABLIM3 Gene

SOURCE GeneReport for Unigene cluster for ABLIM3 Gene Hs.49688

mRNA Expression by UniProt/SwissProt for ABLIM3 Gene

Tissue specificity: Expressed predominantly in heart and brain.
genes like me logo Genes that share expression patterns with ABLIM3: view

Protein tissue co-expression partners for ABLIM3 Gene

Primer Products

Orthologs for ABLIM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ABLIM3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ABLIM3 35
  • 93.41 (n)
  • 98.1 (a)
  • 98 (a)
(Canis familiaris)
Mammalia ABLIM3 35
  • 94.19 (n)
  • 98.83 (a)
  • 98 (a)
(Mus musculus)
Mammalia Ablim3 35
  • 91.84 (n)
  • 98.09 (a)
Ablim3 16
Ablim3 36
  • 98 (a)
(Pan troglodytes)
Mammalia ABLIM3 35
  • 99.76 (n)
  • 99.85 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ablim3 35
  • 92 (n)
  • 98.1 (a)
(Monodelphis domestica)
Mammalia ABLIM3 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia ABLIM3 36
  • 81 (a)
(Gallus gallus)
Aves ABLIM3 35
  • 82 (n)
  • 87.06 (a)
  • 71 (a)
(Anolis carolinensis)
Reptilia ABLIM3 36
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ablim3 35
  • 76.1 (n)
  • 84.13 (a)
(Danio rerio)
Actinopterygii ablim3 36
  • 75 (a)
ablim3 36
  • 74 (a)
ABLIM3 (2 of 3) 36
  • 74 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005425 35
  • 52.46 (n)
  • 43.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta Unc-115a 35
  • 49.17 (n)
  • 40.9 (a)
Species with no ortholog for ABLIM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABLIM3 Gene

Gene Tree for ABLIM3 (if available)
Gene Tree for ABLIM3 (if available)

Paralogs for ABLIM3 Gene

Paralogs for ABLIM3 Gene

(6) SIMAP similar genes for ABLIM3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ABLIM3: view

Variants for ABLIM3 Gene

Sequence variations from dbSNP and Humsavar for ABLIM3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs35907283 - 149,200,354(-) CTTTA(C/T)CGCTG reference, missense
rs748066 -- 149,240,972(-) GGAGG(C/T)TGGTT intron-variant, utr-variant-3-prime
rs9512 -- 149,260,199(-) CACCC(C/T)ATCAC utr-variant-3-prime
rs756056 -- 149,206,738(-) CCTGC(A/G)CTGCT intron-variant
rs765485 -- 149,219,543(+) AGTGC(A/G)TCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABLIM3 Gene

Variant ID Type Subtype PubMed ID
nsv830517 CNV Gain 17160897
nsv517567 CNV Gain 19592680
esv2159994 CNV Deletion 18987734
esv2599932 CNV Deletion 19546169
esv2479942 CNV Deletion 19546169
nsv329799 CNV Loss 16902084
esv2319677 CNV Deletion 18987734
esv2730903 CNV Deletion 23290073
esv1941617 CNV Deletion 18987734
esv2742645 CNV Deletion 23290073
esv2730904 CNV Deletion 23290073
esv1009293 CNV Deletion 20482838
nsv328915 CNV Loss 16902084
esv1067040 CNV Insertion 17803354
esv1591742 CNV Deletion 17803354

Variation tolerance for ABLIM3 Gene

Residual Variation Intolerance Score: 70.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.84; 48.01% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ABLIM3 Gene

Disorders for ABLIM3 Gene

Relevant External Links for ABLIM3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ABLIM3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABLIM3 Gene

Publications for ABLIM3 Gene

  1. Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin. (PMID: 17194709) Barrientos T. … Frey N. (J. Biol. Chem. 2007) 3 4 67
  2. Actin binding LIM protein 3 (abLIM3). (PMID: 16328021) Krupp M. … Teufel A. (Int. J. Mol. Med. 2006) 3 23
  3. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. (PMID: 25184681) Hill S.J. … Livingston D.M. (Genes Dev. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson S.A. … Youle R.J. (Nature 2013) 3

Products for ABLIM3 Gene

Sources for ABLIM3 Gene