Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ABLIM3 Gene

protein-coding   GIFtS: 60
GCID: GC05P148501

Actin Binding LIM Protein Family, Member 3

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Actin Binding LIM Protein Family, Member 31 2
Actin-Binding LIM Protein Family Member 32 3
abLIM-32 3
Actin-Binding LIM Protein 32
KIAA08433

External Ids:    HGNC: 291321   Entrez Gene: 228852   Ensembl: ENSG000001732107   OMIM: 6113055   UniProtKB: O949293   

Export aliases for ABLIM3 gene to outside databases

Previous GC identifers: GC05P148549 GC05P143667


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ABLIM3 Gene:
The LIM domain is a double zinc finger structure that promotes protein-protein interactions. LIM domain proteins,
such as ABLIM3, play roles in embryonic development, cell lineage determination, and cancer (Krupp et al., 2006
(PubMed 16328021)).(supplied by OMIM, Mar 2008)

GeneCards Summary for ABLIM3 Gene:
ABLIM3 (actin binding LIM protein family, member 3) is a protein-coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is LPP.

UniProtKB/Swiss-Prot: ABLM3_HUMAN, O94929
Function: May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity

Gene Wiki entry for ABLIM3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_029289.12  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ABLIM3 gene promoter:
         RFX1   Sox5   AML1a   LCR-F1   E47   POU2F1   POU2F1a   POU2F1b   Hand1   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidABLIM3 promoter sequence
   Search Chromatin IP Primers for ABLIM3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ABLIM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q33.1

ABLIM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABLIM3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P148501:  view genomic region     (about GC identifiers)

Start:
148,521,046 bp from pter      End:
148,640,105 bp from pter
Size:
119,060 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ABLM3_HUMAN, O94929 (See protein sequence)
Recommended Name: Actin-binding LIM protein 3  
Size: 683 amino acids; 77802 Da
Subunit: Directly interacts with F-actin and ABRA
Sequence caution: Sequence=BAA74866.2; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for ABLIM3:
1UJS (3D)        2DJ7 (3D)    
Secondary accessions: A8K121 Q19VH3 Q658S1 Q68CI5 Q9BV32
Alternative splicing: 4 isoforms:  O94929-1   O94929-2   O94929-3   O94929-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ABLIM3: NX_O94929

Explore proteomics data for ABLIM3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ABLIM3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055760.1  
    ENSEMBL proteins: 
     ENSP00000315841   ENSP00000310309   ENSP00000425394   ENSP00000421002   ENSP00000421183  
     ENSP00000420855   ENSP00000430150   ENSP00000348938  
    Reactome Protein details: O94929

    ABLIM3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ABLIM3
    GenScript Custom Purified and Recombinant Proteins Services for ABLIM3
    Novus Biologicals ABLIM3 Protein
    Novus Biologicals ABLIM3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ABLIM3

     
    Search eBioscience for Proteins for ABLIM3 

    ABLIM3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ABLIM3
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ABLIM3
    Novus Biologicals ABLIM3 Antibodies
    Abcam antibodies for ABLIM3
    Cloud-Clone Corp. Antibodies for ABLIM3
    ThermoFisher Antibodies for ABLIM3
    LSBio Antibodies in human, mouse, rat for ABLIM3

    ABLIM3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ABLIM3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ABLIM3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ABLIM3
    Cloud-Clone Corp. CLIAs for ABLIM3
    Search eBioscience for ELISAs for ABLIM3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR028449 ABLIM3
     IPR001781 Znf_LIM
     IPR003128 Villin_headpiece

    Graphical View of Domain Structure for InterPro Entry O94929

    ProtoNet protein and cluster: O94929

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: ABLM3_HUMAN, O94929
    Similarity: Contains 1 HP (headpiece) domain
    Similarity: Contains 4 LIM zinc-binding domains


    Find genes that share domains with ABLIM3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ABLM3_HUMAN, O94929
    Function: May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with ABLIM3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ABLIM3:
     Increased 8N DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ABLIM3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ABLIM3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ABLIM3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ABLIM3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ABLIM3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ABLIM3 (see all 28):
    hsa-miR-3685 hsa-miR-4311 hsa-miR-188-5p hsa-miR-3660 hsa-miR-605 hsa-miR-548s hsa-miR-410 hsa-miR-508-3p
    SwitchGear 3'UTR luciferase reporter plasmidABLIM3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ABLIM3
    Predesigned siRNA for gene silencing in human, mouse, rat ABLIM3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ABLIM3

    Clone
    Products:
         
    OriGene clones in human, mouse for ABLIM3 (see all 9)
    OriGene ORF clones in mouse, rat for ABLIM3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ABLIM3 (NM_014945)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABLIM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABLIM3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ABLIM3
    Browse ESI BIO Cell Lines and PureStem Progenitors for ABLIM3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABLIM3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ABLM3_HUMAN, O94929: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    cytoskeleton1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with ABLIM3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ABLIM3 About    
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    2Netrin-1 signaling
    Netrin-1 signaling
    DCC mediated attractive signaling0.00
    3Netrin Signaling
    Netrin Signaling
    4Axon guidance
    Axon guidance


    Find genes that share SuperPaths with ABLIM3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ABLIM3
        Netrin Signaling

    1 Reactome Pathway for ABLIM3
        DCC mediated attractive signaling


    1 Kegg Pathway  (Kegg details for ABLIM3):
        Axon guidance

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ABLIM3
    Interactions:

        Search GeneGlobe Interaction Network for ABLIM3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for ABLIM3 (O949293 ENSP000003103094) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTC1P680323, ENSP000002903784I2D: score=2 STRING: ENSP00000290378
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    ABLIM2ENSP000003935114STRING: ENSP00000393511
    DCCENSP000003891404STRING: ENSP00000389140
    NCK1ENSP000002889864STRING: ENSP00000288986
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated ----
    GO:0007010cytoskeleton organization IEA--
    GO:0007411axon guidance TAS--
    GO:0030036actin cytoskeleton organization ----
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--

    Find genes that share ontologies with ABLIM3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ABLIM3 (ABLM3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ABLIM3 gene: 
    NM_014945.2  

    Unigene Cluster for ABLIM3:

    Actin binding LIM protein family, member 3
    Hs.49688  [show with all ESTs]
    Unigene Representative Sequence: AK225769
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326685(uc003lqd.1 uc003lqe.1) ENST00000309868(uc003lpy.2 uc003lqc.1)
    ENST00000506113(uc003lpz.1 uc003lqa.1 uc003lqb.3) ENST00000515171
    ENST00000504238(uc003lqf.3) ENST00000508983 ENST00000515796 ENST00000514212
    ENST00000519549 ENST00000517451 ENST00000502855 ENST00000356541
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ABLIM3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ABLIM3 (see all 28):
    hsa-miR-3685 hsa-miR-4311 hsa-miR-188-5p hsa-miR-3660 hsa-miR-605 hsa-miR-548s hsa-miR-410 hsa-miR-508-3p
    SwitchGear 3'UTR luciferase reporter plasmidABLIM3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ABLIM3
    Predesigned siRNA for gene silencing in human, mouse, rat ABLIM3
    Clone
    Products:
         
    OriGene clones in human, mouse for ABLIM3 (see all 9)
    OriGene ORF clones in mouse, rat for ABLIM3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ABLIM3 (NM_014945)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABLIM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABLIM3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ABLIM3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ABLIM3
      QuantiTect SYBR Green Assays in human, mouse, rat ABLIM3
      QuantiFast Probe-based Assays in human, mouse, rat ABLIM3

    Additional mRNA sequence: 

    AB020650.1 AB075881.1 AK225769.1 AK289736.1 AL833021.1 BC001665.2 BC014463.1 DQ413174.1 

    11 DOTS entries:

    DT.100025415  DT.412336  DT.101977530  DT.95212938  DT.100751551  DT.99963960  DT.120864719  DT.91693987 
    DT.99959096  DT.101969107  DT.120864799 

    3 AceView cDNA sequences:

    AL701274 AL603450 BX474446 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ABLIM3 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^
    SP1:        -                                   -                                                                                   -     -     -               
    SP2:                                            -                                         -     -                       -     -     -     -     -               
    SP3:                                                                                                                    -     -     -     -     -               
    SP4:                                                                                                                                                            
    SP5:                                                                                                                    -                 -     -               

    ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
    SP1:                                          
    SP2:                                -         
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for ABLIM3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ABLIM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGTTGCCT
    ABLIM3 Expression
    About this image


    ABLIM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
     
     NULL (Uncategorized)
             CD31, CD144 positive cells
     
     Liver (Hepatobiliary System)
             Mature Mesothelial Cells Hepatic Mesenchyme
     
     Adipose (Muscoskeletal System)
    ABLIM3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ABLIM3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.49688

    UniProtKB/Swiss-Prot: ABLM3_HUMAN, O94929
    Tissue specificity: Expressed predominantly in heart and brain

        Custom PCR Arrays for ABLIM3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ABLIM3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ABLIM3
    QuantiTect SYBR Green Assays in human, mouse, rat ABLIM3
    QuantiFast Probe-based Assays in human, mouse, rat ABLIM3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABLIM3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ABLIM3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ablim31 , 5 actin binding LIM protein family, member 31, 5 91.84(n)1
    98.09(a)1
      18 (34.77 cM)5
    3197131  NM_198649.31  NP_941051.21 
     617993955 
    chicken
    (Gallus gallus)
    Aves ABLIM31 actin binding LIM protein family, member 3 82(n)
    87.06(a)
      416201  XM_004944856.1  XP_004944913.1 
    lizard
    (Anolis carolinensis)
    Reptilia ABLIM36
    actin binding LIM protein family, member 3
    89(a)
    1 ↔ 1
    2(122890995-123077288)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ablim31 actin binding LIM protein family, member 3 76.1(n)
    84.13(a)
      100494921  XM_002939105.2  XP_002939151.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ablim36
    ablim36
    (see all 3)
    actin binding LIM protein family, member 3
    (see all 3)
    75(a)
    74(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    14(35765305-35926930) ENSDARG00000088168
    14(43308398-43418987) ENSDARG00000029772
    fruit fly
    (Drosophila melanogaster)
    Insecta Unc-115a1 Unc-115a 49.17(n)
    40.9(a)
      261629  NM_141673.5  NP_649930.4 


    ENSEMBL Gene Tree for ABLIM3 (if available)
    TreeFam Gene Tree for ABLIM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ABLIM3 gene
    LPP2  FBLIM12  TRIP62  WTIP2  AJUBA2  DMTN2  ZYX2  ABLIM22  
    LIMD12  ABLIM12  
    6 SIMAP similar genes for ABLIM3 using alignment to 2 protein entries:     ABLM3_HUMAN (see all proteins):
    LIMS1    ABLIM1    ABLIM2    LIMS2    PDLIM5    WTIP

    Find genes that share paralogs with ABLIM3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ABLIM3 (see all 2608)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1809813941,2
    C--148519126(+) AAAATG/TTAGAG 1 -- us2k10--------
    rs42910011,2
    C,F,A,H--148519187(+) AAGCTG/ATTTTA 1 -- us2k128Minor allele frequency- A:0.34NS EA NA WA CSA 2778
    rs1843376981,2
    --148519293(+) TTGGAA/GGTATC 1 -- us2k10--------
    rs1904496311,2
    --148519304(+) TCAGGC/TGTTTG 1 -- us2k10--------
    rs1174897121,2
    C,F--148519373(+) CCCCAT/CTGGAC 1 -- us2k11Minor allele frequency- C:0.03EA 120
    rs1141542341,2
    C,F--148519378(+) TTGGAC/AAAAAT 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1138417501,2
    C--148519418(+) AAGTTC/ATAGGG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1431616991,2
    --148519493(+) CATCAA/CCTCAT 1 -- us2k10--------
    rs1447080321,2
    --148519595(+) CCATGC/TGCTCT 1 -- us2k10--------
    rs796542351,2
    C,F--148519651(+) CTTAAC/TAATCT 1 -- us2k11Minor allele frequency- T:0.05WA 118

    HapMap Linkage Disequilibrium report for ABLIM3 (148521046 - 148640105 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ABLIM3 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1941617CNV Deletion18987734
    esv2479942CNV Deletion19546169
    esv2599932CNV Deletion19546169
    esv1591742CNV Deletion17803354
    esv1009293CNV Deletion20482838
    esv2319677CNV Deletion18987734
    esv2730903CNV Deletion23290073
    esv2742645CNV Deletion23290073
    esv2159994CNV Deletion18987734
    esv2730904CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ABLIM3
    DNA2.0 Custom Variant and Variant Library Synthesis for ABLIM3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611305    OMIM disorders: --


    Find genes that share disorders with ABLIM3           About GenesLikeMe

    Genetic Association Database (GAD): ABLIM3

    Export disorders for ABLIM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ABLIM3 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with ABLIM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin. (PubMed id 17194709)1, 2 Barrientos T.... Frey N. (J. Biol. Chem. 2007)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PubMed id 15221005)1, 2 Yamada S....Nakagawara A. (Oncogene 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    6. Actin binding LIM protein 3 (abLIM3). (PubMed id 16328021)1, 9 Krupp M....Teufel A. (Int. J. Mol. Med. 2006)
    7. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. Phosphoproteome of resting human platelets. (PubMed id 18088087)2 Zahedi R.P.... Sickmann A. (J. Proteome Res. 2008)
    9. Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. (PubMed id 18318008)2 Han G.... Gu J. (Proteomics 2008)
    10. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 22885 HGNC: 29132 AceView: ABLIM3 Ensembl:ENSG00000173210 euGenes: HUgn22885
    ECgene: ABLIM3 Kegg: 22885 H-InvDB: ABLIM3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0843

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ABLIM3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ABLIM3 gene:
    Search GeneIP for patents involving ABLIM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ABLIM3
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ABLIM3  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ABLIM3  
     OriGene qSTAR qPCR primer pairs in human, mouse for ABLIM3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ABLIM3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ABLIM3   OriGene Custom Protein Services for ABLIM3  

     
     
     Block miRNA regulation of human, mouse, rat ABLIM3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ABLIM3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ABLIM3 Predesigned siRNA for gene silencing in human, mouse, rat ABLIM3
     QuantiFast Probe-based Assays in human, mouse, rat ABLIM3 QuantiTect SYBR Green Assays in human, mouse, rat ABLIM3
     Custom PCR Arrays for ABLIM3 Search Chromatin IP Primers for ABLIM3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ABLIM3  Search GeneGlobe Interaction Network for ABLIM3
     Regulatory tfbs in ABLIM3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ABLIM3 GenScript cDNA clones with any tag delivered in your preferred vector for ABLIM3
     GenScript Custom Assay Services for ABLIM3 GenScript Custom overexpressing Cell Line Services for ABLIM3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ABLIM3 (ABLM3)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ABLIM3 antibodies
     ABLIM3 proteins
     ABLIM3 lysates
     Antibodies for ABLIM3
     See all of Abcam's Antibodies, Kits and Proteins for ABLIM3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ABLIM3
     Antibodies for ABLIM3
     ELISAs for ABLIM3
     CLIAs for ABLIM3



     Browse ESI BIO Cell Lines and PureStem Progenitors for ABLIM3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABLIM3
     SwitchGear 3'UTR luciferase reporter plasmids for ABLIM3
     SwitchGear Promoter luciferase reporter plasmids for ABLIM3
     ThermoFisher Antibodies for ABLIM3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABLIM3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ABLIM3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ABLIM3
     LSBio Antibodies in human, mouse, rat for ABLIM3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for ABLIM3
      Search eBioscience for proteins for ABLIM3
      Search eBioscience for elisas for ABLIM3
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ABLIM3 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4