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Aliases for ABLIM3 Gene

Aliases for ABLIM3 Gene

  • Actin Binding LIM Protein Family, Member 3 2 3
  • Actin-Binding LIM Protein Family Member 3 3 4
  • AbLIM-3 3 4
  • Actin-Binding LIM Protein 3 3
  • HMFN1661 3
  • KIAA0843 4

External Ids for ABLIM3 Gene

Previous GeneCards Identifiers for ABLIM3 Gene

  • GC05P148549
  • GC05P148501
  • GC05P143667

Summaries for ABLIM3 Gene

Entrez Gene Summary for ABLIM3 Gene

  • The LIM domain is a double zinc finger structure that promotes protein-protein interactions. LIM domain proteins, such as ABLIM3, play roles in embryonic development, cell lineage determination, and cancer (Krupp et al., 2006 [PubMed 16328021]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ABLIM3 Gene

ABLIM3 (Actin Binding LIM Protein Family, Member 3) is a Protein Coding gene. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include actin binding. An important paralog of this gene is AJUBA.

UniProtKB/Swiss-Prot for ABLIM3 Gene

  • May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.

Gene Wiki entry for ABLIM3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABLIM3 Gene

Genomics for ABLIM3 Gene

Regulatory Elements for ABLIM3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ABLIM3 Gene

Start:
149,141,483 bp from pter
End:
149,260,542 bp from pter
Size:
119,060 bases
Orientation:
Plus strand

Genomic View for ABLIM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABLIM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABLIM3 Gene

Proteins for ABLIM3 Gene

  • Protein details for ABLIM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94929-ABLM3_HUMAN
    Recommended name:
    Actin-binding LIM protein 3
    Protein Accession:
    O94929
    Secondary Accessions:
    • A8K121
    • Q19VH3
    • Q658S1
    • Q68CI5
    • Q9BV32

    Protein attributes for ABLIM3 Gene

    Size:
    683 amino acids
    Molecular mass:
    77802 Da
    Quaternary structure:
    • Directly interacts with F-actin and ABRA.
    SequenceCaution:
    • Sequence=BAA74866.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ABLIM3 Gene

    Alternative splice isoforms for ABLIM3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABLIM3 Gene

Proteomics data for ABLIM3 Gene at MOPED

Post-translational modifications for ABLIM3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ABLIM3 Gene

Domains for ABLIM3 Gene

Protein Domains for ABLIM3 Gene

Suggested Antigen Peptide Sequences for ABLIM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94929

UniProtKB/Swiss-Prot:

ABLM3_HUMAN :
  • O94929
Domain:
  • Contains 1 HP (headpiece) domain.
  • Contains 4 LIM zinc-binding domains.
genes like me logo Genes that share domains with ABLIM3: view

No data available for Gene Families for ABLIM3 Gene

Function for ABLIM3 Gene

Molecular function for ABLIM3 Gene

UniProtKB/Swiss-Prot Function: May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.

Gene Ontology (GO) - Molecular Function for ABLIM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ABLIM3: view

Phenotypes for ABLIM3 Gene

GenomeRNAi human phenotypes for ABLIM3:
genes like me logo Genes that share phenotypes with ABLIM3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABLIM3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ABLIM3 Gene

Localization for ABLIM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABLIM3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABLIM3 Gene COMPARTMENTS Subcellular localization image for ABLIM3 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ABLIM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 22684256
GO:0005737 cytoplasm IEA --
GO:0030027 lamellipodium IDA 22684256
genes like me logo Genes that share ontologies with ABLIM3: view

Pathways for ABLIM3 Gene

genes like me logo Genes that share pathways with ABLIM3: view

Pathways by source for ABLIM3 Gene

1 Qiagen pathway for ABLIM3 Gene
1 KEGG pathway for ABLIM3 Gene

Gene Ontology (GO) - Biological Process for ABLIM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007010 cytoskeleton organization --
GO:0007411 axon guidance TAS --
GO:0030032 lamellipodium assembly IMP 22684256
GO:0030036 actin cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with ABLIM3: view

Transcripts for ABLIM3 Gene

mRNA/cDNA for ABLIM3 Gene

Unigene Clusters for ABLIM3 Gene

Actin binding LIM protein family, member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABLIM3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ABLIM3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABLIM3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^
SP1: - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4:
SP5: - - -
SP6:
SP7:

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for ABLIM3 Gene

GeneLoc Exon Structure for
ABLIM3
ECgene alternative splicing isoforms for
ABLIM3

Expression for ABLIM3 Gene

mRNA expression in normal human tissues for ABLIM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABLIM3 Gene

This gene is overexpressed in Liver (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABLIM3 Gene

SOURCE GeneReport for Unigene cluster for ABLIM3 Gene Hs.49688

mRNA Expression by UniProt/SwissProt for ABLIM3 Gene

O94929-ABLM3_HUMAN
Tissue specificity: Expressed predominantly in heart and brain.
genes like me logo Genes that share expressions with ABLIM3: view

In Situ Assay Products

Orthologs for ABLIM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ABLIM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABLIM3 35
  • 99.76 (n)
  • 99.85 (a)
ABLIM3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ABLIM3 35
  • 93.41 (n)
  • 98.1 (a)
ABLIM3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABLIM3 35
  • 94.19 (n)
  • 98.83 (a)
ABLIM3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ablim3 35
  • 91.84 (n)
  • 98.09 (a)
Ablim3 16
Ablim3 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABLIM3 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABLIM3 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ablim3 35
  • 92 (n)
  • 98.1 (a)
chicken
(Gallus gallus)
Aves ABLIM3 35
  • 82 (n)
  • 87.06 (a)
ABLIM3 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABLIM3 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ablim3 35
  • 76.1 (n)
  • 84.13 (a)
zebrafish
(Danio rerio)
Actinopterygii ablim3 36
  • 75 (a)
OneToMany
ablim3 36
  • 74 (a)
OneToMany
ABLIM3 (2 of 3) 36
  • 74 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005425 35
  • 52.46 (n)
  • 43.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta Unc-115a 35
  • 49.17 (n)
  • 40.9 (a)
Species with no ortholog for ABLIM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABLIM3 Gene

ENSEMBL:
Gene Tree for ABLIM3 (if available)
TreeFam:
Gene Tree for ABLIM3 (if available)

Paralogs for ABLIM3 Gene

Paralogs for ABLIM3 Gene

Selected SIMAP similar genes for ABLIM3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ABLIM3: view

Variants for ABLIM3 Gene

Sequence variations from dbSNP and Humsavar for ABLIM3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs756056 -- 149,206,738(-) CCTGC(A/G)CTGCT intron-variant
rs2068262 -- 149,199,003(-) AAAAG(A/G)ATAAT intron-variant
rs2918279 -- 149,213,450(-) CGCAG(C/T)CCACG intron-variant
rs2918280 -- 149,211,057(-) ATACA(A/T)CTGAT intron-variant
rs2918281 -- 149,210,860(-) CACAG(A/G)TCACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABLIM3 Gene

Variant ID Type Subtype PubMed ID
nsv830517 CNV Gain 17160897
nsv517567 CNV Gain 19592680
esv2159994 CNV Deletion 18987734
esv2599932 CNV Deletion 19546169
esv2479942 CNV Deletion 19546169
nsv329799 CNV Loss 16902084
esv2319677 CNV Deletion 18987734
esv2730903 CNV Deletion 23290073
esv1941617 CNV Deletion 18987734
esv2742645 CNV Deletion 23290073
esv2730904 CNV Deletion 23290073
esv1009293 CNV Deletion 20482838
nsv328915 CNV Loss 16902084
esv1067040 CNV Insertion 17803354
esv1591742 CNV Deletion 17803354

Relevant External Links for ABLIM3 Gene

HapMap Linkage Disequilibrium report
ABLIM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABLIM3 Gene

Disorders for ABLIM3 Gene

Relevant External Links for ABLIM3

Genetic Association Database (GAD)
ABLIM3
genes like me logo Genes that share disorders with ABLIM3: view

No data available for UniProtKB/Swiss-Prot for ABLIM3 Gene

Publications for ABLIM3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  2. Actin binding LIM protein 3 (abLIM3). (PMID: 16328021) Krupp M. … Teufel A. (Int. J. Mol. Med. 2006) 3 23
  3. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S. … Nakagawara A. (Oncogene 2004) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin. (PMID: 17194709) Barrientos T. … Frey N. (J. Biol. Chem. 2007) 3 4

Products for ABLIM3 Gene

Sources for ABLIM3 Gene

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