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Aliases for ABLIM2 Gene

Aliases for ABLIM2 Gene

  • Actin Binding LIM Protein Family, Member 2 2 3
  • Actin-Binding LIM Protein Family Member 2 3 4
  • Actin Binding LIM Protein 2 2 3
  • KIAA1808 4 6
  • AbLIM-2 3 4
  • Actin-Binding LIM Protein 2 3

External Ids for ABLIM2 Gene

Summaries for ABLIM2 Gene

GeneCards Summary for ABLIM2 Gene

ABLIM2 (Actin Binding LIM Protein Family, Member 2) is a Protein Coding gene. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include actin binding. An important paralog of this gene is AJUBA.

UniProtKB/Swiss-Prot for ABLIM2 Gene

  • May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABLIM2 Gene

Genomics for ABLIM2 Gene

Genomic Location for ABLIM2 Gene

Start:
7,965,310 bp from pter
End:
8,158,832 bp from pter
Size:
193,523 bases
Orientation:
Minus strand

Genomic View for ABLIM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABLIM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABLIM2 Gene

Regulatory Elements for ABLIM2 Gene

Proteins for ABLIM2 Gene

  • Protein details for ABLIM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6H8Q1-ABLM2_HUMAN
    Recommended name:
    Actin-binding LIM protein 2
    Protein Accession:
    Q6H8Q1
    Secondary Accessions:
    • E9PF39
    • Q08E71
    • Q19VH0
    • Q6H8Q0
    • Q6NX73
    • Q8N3C5
    • Q8N9E9
    • Q8N9G2
    • Q96JL7

    Protein attributes for ABLIM2 Gene

    Size:
    611 amino acids
    Molecular mass:
    67812 Da
    Quaternary structure:
    • Interacts with F-actin and ABRA.
    SequenceCaution:
    • Sequence=AAH67214.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ABLIM2 Gene

    Alternative splice isoforms for ABLIM2 Gene

neXtProt entry for ABLIM2 Gene

Proteomics data for ABLIM2 Gene at MOPED

Post-translational modifications for ABLIM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ABLIM2 Gene

Domains for ABLIM2 Gene

Protein Domains for ABLIM2 Gene

Suggested Antigen Peptide Sequences for ABLIM2 Gene

Graphical View of Domain Structure for InterPro Entry

Q6H8Q1

UniProtKB/Swiss-Prot:

ABLM2_HUMAN
Domain:
  • Contains 1 HP (headpiece) domain.:
    • Q6H8Q1
  • Contains 4 LIM zinc-binding domains.:
    • Q6H8Q1
genes like me logo Genes that share domains with ABLIM2: view

No data available for Gene Families for ABLIM2 Gene

Function for ABLIM2 Gene

Molecular function for ABLIM2 Gene

UniProtKB/Swiss-Prot Function: May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.

Gene Ontology (GO) - Molecular Function for ABLIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ABLIM2: view

Phenotypes for ABLIM2 Gene

GenomeRNAi human phenotypes for ABLIM2:
genes like me logo Genes that share phenotypes with ABLIM2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ABLIM2 Gene

Localization for ABLIM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABLIM2 Gene

Cytoplasm. Note=In skeletal muscle, sarcomeric or cosarcomeric localization. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABLIM2 Gene COMPARTMENTS Subcellular localization image for ABLIM2 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for ABLIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015629 actin cytoskeleton IDA 17194709
GO:0030016 myofibril IEA --
genes like me logo Genes that share ontologies with ABLIM2: view

Pathways for ABLIM2 Gene

genes like me logo Genes that share pathways with ABLIM2: view

Pathways by source for ABLIM2 Gene

1 Qiagen pathway for ABLIM2 Gene
1 KEGG pathway for ABLIM2 Gene

Gene Ontology (GO) - Biological Process for ABLIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007010 cytoskeleton organization --
GO:0007411 axon guidance TAS --
GO:0030036 actin cytoskeleton organization IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ABLIM2: view

Transcripts for ABLIM2 Gene

Unigene Clusters for ABLIM2 Gene

Actin binding LIM protein family, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABLIM2 Gene

No ASD Table

Relevant External Links for ABLIM2 Gene

GeneLoc Exon Structure for
ABLIM2
ECgene alternative splicing isoforms for
ABLIM2

Expression for ABLIM2 Gene

mRNA expression in normal human tissues for ABLIM2 Gene

mRNA differential expression in normal tissues according to GTEx for ABLIM2 Gene

This gene is overexpressed in Muscle - Skeletal (17.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ABLIM2 Gene

SOURCE GeneReport for Unigene cluster for ABLIM2 Gene Hs.233404

mRNA Expression by UniProt/SwissProt for ABLIM2 Gene

Q6H8Q1-ABLM2_HUMAN
Tissue specificity: Highly expressed in skeletal muscle.
genes like me logo Genes that share expressions with ABLIM2: view

Orthologs for ABLIM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ABLIM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABLIM2 35
  • 99.17 (n)
  • 99.53 (a)
ABLIM2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ABLIM2 35
  • 89.79 (n)
  • 91.25 (a)
ABLIM2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABLIM2 35
  • 90.7 (n)
  • 92.56 (a)
ABLIM2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ablim2 35
  • 87.47 (n)
  • 91.61 (a)
Ablim2 16
Ablim2 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABLIM2 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ablim2 35
  • 85.92 (n)
  • 90.67 (a)
chicken
(Gallus gallus)
Aves ABLIM2 35
  • 76.9 (n)
  • 82.87 (a)
ABLIM2 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABLIM2 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ablim2 35
  • 72.12 (n)
  • 76.18 (a)
zebrafish
(Danio rerio)
Actinopterygii ablim2 35
  • 69.35 (n)
  • 69.93 (a)
ablim2 36
  • 62 (a)
OneToOne
Species with no ortholog for ABLIM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABLIM2 Gene

ENSEMBL:
Gene Tree for ABLIM2 (if available)
TreeFam:
Gene Tree for ABLIM2 (if available)

Paralogs for ABLIM2 Gene

Paralogs for ABLIM2 Gene

Selected SIMAP similar genes for ABLIM2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ABLIM2: view

Variants for ABLIM2 Gene

Sequence variations from dbSNP and Humsavar for ABLIM2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1320061 -- 8,049,287(-) GCCTC(A/G)GGCGT intron-variant
rs1320060 -- 8,054,470(-) GCCTC(C/T)GTCCC intron-variant
rs1320059 -- 8,054,478(-) TGTTT(C/G)CTGCC intron-variant
rs1320058 -- 8,058,910(+) AACCA(C/T)CTTGT intron-variant
rs1320057 -- 8,071,234(-) GGCTG(G/T)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABLIM2 Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER Inversion 12058347
esv34140 CNV Loss 18971310
nsv878578 CNV Gain 21882294
nsv829851 CNV Loss 17160897
nsv469779 CNV Complex 16826518
nsv878579 CNV Loss 21882294
esv2677688 CNV Deletion 23128226
esv23700 CNV Loss 19812545
esv2727097 CNV Deletion 23290073
nsv829852 CNV Gain+Loss 17160897
esv4240 CNV Deletion 18987735
esv1000260 CNV Deletion 20482838
esv2727098 CNV Deletion 23290073
esv1632857 CNV Deletion 17803354
nsv878580 CNV Loss 21882294
nsv470009 CNV Loss 18288195
dgv5451n71 CNV Loss 21882294
dgv5452n71 CNV Loss 21882294
dgv5453n71 CNV Loss 21882294
nsv878586 CNV Loss 21882294
nsv878588 CNV Loss 21882294
esv2727099 CNV Deletion 23290073
nsv508997 CNV Insertion 20534489
nsv878590 CNV Loss 21882294
nsv878591 CNV Loss 21882294
dgv643n27 CNV Loss 19166990
nsv878592 CNV Gain 21882294
nsv878593 CNV Loss 21882294
esv2727100 CNV Deletion 23290073
esv2727101 CNV Deletion 23290073
nsv290326 CNV Loss 16902084
nsv290664 CNV Loss 16902084
esv2659230 CNV Deletion 23128226
nsv461216 CNV Loss 19166990
dgv5454n71 CNV Loss 21882294
dgv5455n71 CNV Loss 21882294

Relevant External Links for ABLIM2 Gene

HapMap Linkage Disequilibrium report
ABLIM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABLIM2 Gene

Disorders for ABLIM2 Gene

(1) University of Copenhagen DISEASES for ABLIM2 Gene

Relevant External Links for ABLIM2

Genetic Association Database (GAD)
ABLIM2
Human Genome Epidemiology (HuGE) Navigator
ABLIM2
genes like me logo Genes that share disorders with ABLIM2: view

No data available for UniProtKB/Swiss-Prot for ABLIM2 Gene

Publications for ABLIM2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  4. Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin. (PMID: 17194709) Barrientos T. … Frey N. (J. Biol. Chem. 2007) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for ABLIM2 Gene

Sources for ABLIM2 Gene

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