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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ABLIM2 Gene

protein-coding   GIFtS: 53
GCID: GC04M007967

actin binding LIM protein family, member 2

(Previous name: actin binding LIM protein 2 )
 Explore 3 diseases affiliated with
ABLIM2 via our new
 Human Malady Compendium 
Biological research products
for ABLIM2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Actin Binding LIM Protein Family, Member 21 2
KIAA18081 3 5
Actin Binding LIM Protein 21 2
Actin-Binding LIM Protein Family Member 22 3
AbLIM-21
Actin-Binding LIM Protein 22

External Ids:    HGNC: 191951   Entrez Gene: 844482   Ensembl: ENSG000001639957   OMIM: 6125445   UniProtKB: Q6H8Q13   

Export aliases for ABLIM2 gene to outside databases

Previous GC identifers: GC04M007934 GC04M008116 GC04M008159 GC04M008085 GC04M008017


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ABLM2_HUMAN, Q6H8Q1
Function: May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006051.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ABLIM2 gene promoter:
         Egr-3   AML1a   POU6F1 (c2)   CUTL1   POU3F2   YY1   CREB   Nkx6-1   Sox9   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidABLIM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ABLIM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABLIM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1   Ensembl cytogenetic band:  4p16.1   HGNC cytogenetic band: 4p16.1

ABLIM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABLIM2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M007967:  view genomic region     (about GC identifiers)

Start:
7,967,037 bp from pter      End:
8,160,559 bp from pter
Size:
193,523 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ABLM2_HUMAN, Q6H8Q1 (See protein sequence)
Recommended Name: Actin-binding LIM protein 2  
Size: 611 amino acids; 67812 Da
Subunit: Interacts with F-actin and ABRA
Subcellular location: Cytoplasm. Note=In skeletal muscle, sarcomeric or cosarcomeric localization (By similarity)
Sequence caution: Sequence=AAH67214.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for ABLIM2:
1V6G (3D)        1WIG (3D)        2L3X (3D)    
Secondary accessions: Q08E71 Q19VH0 Q6H8Q0 Q6NX73 Q8N3C5 Q8N9E9 Q8N9G2 Q96JL7
Alternative splicing: 8 isoforms:  Q6H8Q1-1   Q6H8Q1-2   Q6H8Q1-3   Q6H8Q1-4   Q6H8Q1-5   Q6H8Q1-6   Q6H8Q1-7   Q6H8Q1-8   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ABLIM2: NX_Q6H8Q1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6H8Q1

  • ABLIM2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (7 alternative transcripts): 
    NP_001123555.1  NP_001123556.1  NP_001123557.1  NP_001123558.1  NP_001123559.1  NP_001123560.1  NP_115808.3  

    ENSEMBL proteins: 
     ENSP00000354887   ENSP00000423661   ENSP00000393511   ENSP00000342813   ENSP00000355003  
     ENSP00000384658   ENSP00000421283   ENSP00000389410   ENSP00000421718   ENSP00000296372  
     ENSP00000441255   ENSP00000444365   ENSP00000317020  
    Reactome Protein details: Q6H8Q1
    Human Recombinant Protein Products: 
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ABLIM2

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm NAS--
    GO:0015629actin cytoskeleton IDA17194709
    GO:0030016myofibril ----


    ABLIM2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ABLIM2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001781 Znf_LIM
     IPR003128 Villin_headpiece

    Graphical View of Domain Structure for InterPro Entry Q6H8Q1

    ProtoNet protein and cluster: Q6H8Q1

    1 Blocks protein family: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: ABLM2_HUMAN, Q6H8Q1
    Similarity: Contains 1 HP (headpiece) domain
    Similarity: Contains 4 LIM zinc-binding domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ABLM2_HUMAN, Q6H8Q1
    Function: May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity

    miRNA
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    hsa-miR-3163 hsa-miR-548d-3p hsa-miR-548am hsa-miR-3155 hsa-miR-342-3p hsa-miR-484 hsa-miR-3605-5p hsa-miR-582-5p
    SwitchGear 3'UTR luciferase reporter plasmidABLIM2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABLIM2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0008270zinc ion binding NAS--


    ABLIM2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ABLIM2:
     Increased S DNA content  Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Axon guidance
    Axon guidance1.00
    Developmental Biology0.69
    2Netrin-1 signaling
    Netrin-1 signaling1.00
    DCC mediated attractive signaling0.33
    3Netrin Signaling
    Netrin Signaling1.00
    4Axon guidance
    Axon guidance1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ABLIM2
        Netrin Signaling

    4        Reactome Pathways for ABLIM2
        Developmental Biology
    Netrin-1 signaling
    DCC mediated attractive signaling
    Axon guidance


    1         Kegg Pathway  (Kegg details for ABLIM2):
        Axon guidance


    ABLIM2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ABLIM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/12 Interacting proteins for ABLIM2 (Q6H8Q13 ENSP000003935114) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SREBF2Q127723, ENSP000003544764I2D: score=3 STRING: ENSP00000354476
    ABLIM1ENSP000003381904STRING: ENSP00000338190
    ABLIM3ENSP000003103094STRING: ENSP00000310309
    NTN1ENSP000001732294STRING: ENSP00000173229
    DCCENSP000003891404STRING: ENSP00000389140
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization IEA--
    GO:0007411axon guidance TAS--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter ----


    ABLIM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ABLIM2
    Search CenterWatch for drugs/clinical trials and news about ABLIM2 / ABLM2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ABLIM2 gene (7 alternative transcripts): 
    NM_001130083.1  NM_001130084.1  NM_001130085.1  NM_001130086.1  NM_001130087.1  NM_001130088.1  NM_032432.4  

    Unigene Cluster for ABLIM2:

    Actin binding LIM protein family, member 2
    Hs.233404  [show with all ESTs]
    Unigene Representative Sequence: NM_001130083
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512594(uc003gkk.3) ENST00000361737 ENST00000509819(uc003gki.3)
    ENST00000514025(uc003gkl.3) ENST00000447017 ENST00000341937 ENST00000361581
    ENST00000407564 ENST00000505872(uc011bwl.1) ENST00000428004(uc003gks.3)
    ENST00000504172 ENST00000510277 ENST00000515079 ENST00000502800 ENST00000296372
    ENST00000545242(uc003gkq.3) ENST00000546334 ENST00000318888(uc003gkj.4 uc003gko.3 uc003gkm.4 uc003gkp.3 uc003gkr.3)


    miRNA
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    hsa-miR-3163 hsa-miR-548d-3p hsa-miR-548am hsa-miR-3155 hsa-miR-342-3p hsa-miR-484 hsa-miR-3605-5p hsa-miR-582-5p
    SwitchGear 3'UTR luciferase reporter plasmidABLIM2 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABLIM2

    Additional cDNA sequence: 

    AB058711.1 AJ431609.1 AJ748600.1 AJ748601.1 AK094754.1 AK094798.1 AK097003.1 AK301060.1 
    BC067214.1 BC122567.1 DQ413176.1 DQ413177.1 

    14 DOTS entries:

    DT.312960  DT.40211462  DT.40269666  DT.95284235  DT.100023808  DT.100775219  DT.97790357  DT.121261945 
    DT.121261978  DT.97782668  DT.97843868  DT.121261976  DT.92024999  DT.75107097 

    24/119 AceView cDNA sequences (see all 119):

    AK097003 BM701988 NM_032432 AI680764 BM718728 AA434113 AI074682 BI836676 
    BU739256 BX463502 CK823316 BM966915 BM967089 AI699790 BU742385 CB177979 
    AA191013 BM714622 BE221288 BM893795 BF807987 AW136674 AI693896 AI567505 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ABLIM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ABLIM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ABLIM2

    SOURCE GeneReport for Unigene cluster: Hs.233404

    UniProtKB/Swiss-Prot: ABLM2_HUMAN, Q6H8Q1
    Tissue specificity: Highly expressed in skeletal muscle

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABLIM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ABLIM2 gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ABLIM21 actin binding LIM protein family, member 2 75.05(n)
    81.41(a)
      422866  XM_420811.3  XP_420811.3 
    lizard
    (Anolis carolinensis)
    Reptilia ABLIM26
    --
    75(a)
    1 ↔ 1
    GL343236.1(1426686-1480299)
    zebrafish
    (Danio rerio)
    Actinopterygii ablim21 actin binding LIM protein family, member 2 69.97(n)
    71.28(a)
      568454  XM_691783.5  XP_696875.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta Unc-115a6
    Unc-115b6
    --
    25(a)
    22(a)
    many ↔ many
    many ↔ many
    3R(5520444-5531165)
    3R(5512782-5518497)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-1156
    UNCoordinated family member (unc-115)
    22(a)
    1 → many
    X(10146833-10152726)


    ENSEMBL Gene Tree for ABLIM2 (if available)
    TreeFam Gene Tree for ABLIM2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ABLIM2 gene
    ABLIM32  LIMS12  LIMS3L2  FHL52  LDB32  LPXN2  PDLIM52  ENSG000002572072  
    LIMS22  FHL22  ABLIM12  PDLIM72  EPB492  FHL32  FHL12  TGFB1I12  
    LIMS32  PXN2  
    16 SIMAP similar genes for ABLIM2 using alignment to 8 protein entries:     ABLM2_HUMAN (see all proteins):
    DKFZp686P2249    ABLIM3    LHX2    LHX8    ABLIM1    LHx4
    LMO3    CRIP1    LIMS1    LMO1    ISL2    AJUBA
    LHX3    LIMS2    LMO2    LMO4

    ABLIM2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 16 variations for ABLIM2
         11 CNVs: 47968 23736 4373 30197 43314 53248 80177 39356 4374 63742 30198
         5 Indels: 91919 80178 12403 80176 12402
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABLIM2
    DNA2.0 Custom Variant and Variant Library Synthesis for ABLIM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ABLIM2 for disorders           About GeneDecksing

    OMIM gene information: 612544    OMIM disorders: --

    3 diseases for ABLIM2:    About MalaCards
    hepatoblastoma    pancreatic cancer    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for ABLIM2:
    Hepatoblastoma
    Human Genome Epidemiology (HuGE) Navigator: ABLIM2 (1 document)

    Export disorders for ABLIM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ABLIM2 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with ABLIM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin. (PubMed id 17194709)1, 2 Barrientos T.... Frey N. (2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (2001)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    6. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
    7. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. (PubMed id 18772397)2 Jones S.... Kinzler K.W. (2008)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. Genomic organisation and tissue specific expression of ABLIM2 gene in human, mouse and rat. (PubMed id 16005990)1 Klimov E....Sulimova G. (2005)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84448 HGNC: 19195 AceView: ABLIM2 Ensembl:ENSG00000163995 euGenes: HUgn84448
    ECgene: ABLIM2 Kegg: 84448 H-InvDB: ABLIM2

    (According to HUGE)
    About This Section
    HUGE: KIAA1808

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ABLIM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for ABLIM2 gene:
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