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Aliases for ABLIM2 Gene

Aliases for ABLIM2 Gene

  • Actin Binding LIM Protein Family Member 2 2 3 5
  • Actin Binding LIM Protein Family, Member 2 2 3
  • Actin-Binding LIM Protein Family Member 2 3 4
  • Actin Binding LIM Protein 2 2 3
  • AbLIM-2 3 4
  • Testis Tissue Sperm-Binding Protein Li 35a 3
  • KIAA1808 4

External Ids for ABLIM2 Gene

Previous GeneCards Identifiers for ABLIM2 Gene

  • GC04M007934
  • GC04M008116
  • GC04M008159
  • GC04M008085
  • GC04M008017

Summaries for ABLIM2 Gene

GeneCards Summary for ABLIM2 Gene

ABLIM2 (Actin Binding LIM Protein Family Member 2) is a Protein Coding gene. Among its related pathways are Developmental Biology and Axon guidance. GO annotations related to this gene include actin binding. An important paralog of this gene is AJUBA.

UniProtKB/Swiss-Prot for ABLIM2 Gene

  • May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABLIM2 Gene

Genomics for ABLIM2 Gene

Regulatory Elements for ABLIM2 Gene

Promoters for ABLIM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ABLIM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ABLIM2 Gene

Chromosome:
4
Start:
7,965,310 bp from pter
End:
8,158,832 bp from pter
Size:
193,523 bases
Orientation:
Minus strand

Genomic View for ABLIM2 Gene

Genes around ABLIM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABLIM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABLIM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABLIM2 Gene

Proteins for ABLIM2 Gene

  • Protein details for ABLIM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6H8Q1-ABLM2_HUMAN
    Recommended name:
    Actin-binding LIM protein 2
    Protein Accession:
    Q6H8Q1
    Secondary Accessions:
    • E9PF39
    • Q08E71
    • Q19VH0
    • Q6H8Q0
    • Q6NX73
    • Q8N3C5
    • Q8N9E9
    • Q8N9G2
    • Q96JL7

    Protein attributes for ABLIM2 Gene

    Size:
    611 amino acids
    Molecular mass:
    67812 Da
    Quaternary structure:
    • Interacts with F-actin and ABRA.
    SequenceCaution:
    • Sequence=AAH67214.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ABLIM2 Gene

    Alternative splice isoforms for ABLIM2 Gene

neXtProt entry for ABLIM2 Gene

Proteomics data for ABLIM2 Gene at MOPED

Post-translational modifications for ABLIM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ABLIM2 Gene

Domains & Families for ABLIM2 Gene

Gene Families for ABLIM2 Gene

Protein Domains for ABLIM2 Gene

Suggested Antigen Peptide Sequences for ABLIM2 Gene

Graphical View of Domain Structure for InterPro Entry

Q6H8Q1

UniProtKB/Swiss-Prot:

ABLM2_HUMAN :
  • Contains 1 HP (headpiece) domain.
Domain:
  • Contains 1 HP (headpiece) domain.
  • Contains 4 LIM zinc-binding domains.
genes like me logo Genes that share domains with ABLIM2: view

Function for ABLIM2 Gene

Molecular function for ABLIM2 Gene

UniProtKB/Swiss-Prot Function:
May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.
genes like me logo Genes that share phenotypes with ABLIM2: view

miRNA for ABLIM2 Gene

miRTarBase miRNAs that target ABLIM2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABLIM2 Gene

Localization for ABLIM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABLIM2 Gene

Cytoplasm. Note=In skeletal muscle, sarcomeric or cosarcomeric localization. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABLIM2 Gene COMPARTMENTS Subcellular localization image for ABLIM2 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for ABLIM2 Gene

Pathways & Interactions for ABLIM2 Gene

genes like me logo Genes that share pathways with ABLIM2: view

Pathways by source for ABLIM2 Gene

1 KEGG pathway for ABLIM2 Gene
1 Qiagen pathway for ABLIM2 Gene

Gene Ontology (GO) - Biological Process for ABLIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007411 axon guidance TAS --
GO:0030036 actin cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with ABLIM2: view

No data available for SIGNOR curated interactions for ABLIM2 Gene

Drugs & Compounds for ABLIM2 Gene

No Compound Related Data Available

Transcripts for ABLIM2 Gene

Unigene Clusters for ABLIM2 Gene

Actin binding LIM protein family, member 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABLIM2 Gene

No ASD Table

Relevant External Links for ABLIM2 Gene

GeneLoc Exon Structure for
ABLIM2
ECgene alternative splicing isoforms for
ABLIM2

Expression for ABLIM2 Gene

mRNA expression in normal human tissues for ABLIM2 Gene

mRNA differential expression in normal tissues according to GTEx for ABLIM2 Gene

This gene is overexpressed in Muscle - Skeletal (x17.7).

Protein differential expression in normal tissues from HIPED for ABLIM2 Gene

This gene is overexpressed in Frontal cortex (26.2), Fetal Brain (17.5), and Retina (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ABLIM2 Gene



SOURCE GeneReport for Unigene cluster for ABLIM2 Gene Hs.233404

mRNA Expression by UniProt/SwissProt for ABLIM2 Gene

Q6H8Q1-ABLM2_HUMAN
Tissue specificity: Highly expressed in skeletal muscle.
genes like me logo Genes that share expression patterns with ABLIM2: view

Protein tissue co-expression partners for ABLIM2 Gene

Primer Products

In Situ Assay Products

Orthologs for ABLIM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ABLIM2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ABLIM2 35
  • 89.79 (n)
  • 91.25 (a)
ABLIM2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABLIM2 35
  • 90.7 (n)
  • 92.56 (a)
ABLIM2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ablim2 35
  • 87.47 (n)
  • 91.61 (a)
Ablim2 16
Ablim2 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ABLIM2 35
  • 99.17 (n)
  • 99.53 (a)
ABLIM2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ablim2 35
  • 85.92 (n)
  • 90.67 (a)
oppossum
(Monodelphis domestica)
Mammalia ABLIM2 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ABLIM2 35
  • 76.9 (n)
  • 82.87 (a)
ABLIM2 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABLIM2 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ablim2 35
  • 72.12 (n)
  • 76.18 (a)
zebrafish
(Danio rerio)
Actinopterygii ablim2 35
  • 69.35 (n)
  • 69.93 (a)
ablim2 36
  • 62 (a)
OneToOne
Species with no ortholog for ABLIM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABLIM2 Gene

ENSEMBL:
Gene Tree for ABLIM2 (if available)
TreeFam:
Gene Tree for ABLIM2 (if available)

Paralogs for ABLIM2 Gene

Paralogs for ABLIM2 Gene

genes like me logo Genes that share paralogs with ABLIM2: view

Variants for ABLIM2 Gene

Sequence variations from dbSNP and Humsavar for ABLIM2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_062665 A pancreatic ductal adenocarcinoma sample
VAR_062666 A pancreatic ductal adenocarcinoma sample
rs11448 -- 7,965,662(-) CGGCC(A/G)TCACA nc-transcript-variant, utr-variant-3-prime
rs938603 -- 8,052,586(-) CTAGC(A/G)GCTCT intron-variant
rs1320057 -- 8,071,234(-) GGCTG(G/T)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABLIM2 Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER Inversion 12058347
esv34140 CNV Loss 18971310
nsv878578 CNV Gain 21882294
nsv829851 CNV Loss 17160897
nsv469779 CNV Complex 16826518
nsv878579 CNV Loss 21882294
esv2677688 CNV Deletion 23128226
esv23700 CNV Loss 19812545
esv2727097 CNV Deletion 23290073
nsv829852 CNV Gain+Loss 17160897
esv4240 CNV Deletion 18987735
esv1000260 CNV Deletion 20482838
esv2727098 CNV Deletion 23290073
esv1632857 CNV Deletion 17803354
nsv878580 CNV Loss 21882294
nsv470009 CNV Loss 18288195
dgv5451n71 CNV Loss 21882294
dgv5452n71 CNV Loss 21882294
dgv5453n71 CNV Loss 21882294
nsv878586 CNV Loss 21882294
nsv878588 CNV Loss 21882294
esv2727099 CNV Deletion 23290073
nsv508997 CNV Insertion 20534489
nsv878590 CNV Loss 21882294
nsv878591 CNV Loss 21882294
dgv643n27 CNV Loss 19166990
nsv878592 CNV Gain 21882294
nsv878593 CNV Loss 21882294
esv2727100 CNV Deletion 23290073
esv2727101 CNV Deletion 23290073
nsv290326 CNV Loss 16902084
nsv290664 CNV Loss 16902084
esv2659230 CNV Deletion 23128226
nsv461216 CNV Loss 19166990
dgv5454n71 CNV Loss 21882294
dgv5455n71 CNV Loss 21882294

Variation tolerance for ABLIM2 Gene

Residual Variation Intolerance Score: 48.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABLIM2 Gene

HapMap Linkage Disequilibrium report
ABLIM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABLIM2 Gene

Disorders for ABLIM2 Gene

Relevant External Links for ABLIM2

Genetic Association Database (GAD)
ABLIM2
Human Genome Epidemiology (HuGE) Navigator
ABLIM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABLIM2

No disorders were found for ABLIM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABLIM2 Gene

Publications for ABLIM2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin. (PMID: 17194709) Barrientos T. … Frey N. (J. Biol. Chem. 2007) 3

Products for ABLIM2 Gene

Sources for ABLIM2 Gene

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