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Aliases for ABLIM1 Gene

Aliases for ABLIM1 Gene

  • Actin Binding LIM Protein 1 2 3 5
  • Actin-Binding LIM Protein Family Member 1 3 4
  • LIMATIN 3 4
  • AbLIM-1 3 4
  • LIMAB1 3 4
  • ABLIM 3 4
  • Actin-Binding Double-Zinc-Finger Protein 3
  • Actin-Binding Double Zinc Finger Protein 4
  • KIAA0059 4

External Ids for ABLIM1 Gene

Previous HGNC Symbols for ABLIM1 Gene

  • LIMAB1
  • ABLIM

Previous GeneCards Identifiers for ABLIM1 Gene

  • GC10M115109
  • GC10M115434
  • GC10M116322
  • GC10M115855
  • GC10M116180
  • GC10M116190
  • GC10M109817

Summaries for ABLIM1 Gene

Entrez Gene Summary for ABLIM1 Gene

  • This gene encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. The protein encoded by this gene could mediate such interactions between actin filaments and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABLIM1 Gene

ABLIM1 (Actin Binding LIM Protein 1) is a Protein Coding gene. Among its related pathways are Developmental Biology and Axon guidance. GO annotations related to this gene include actin binding. An important paralog of this gene is AJUBA.

UniProtKB/Swiss-Prot for ABLIM1 Gene

  • May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance.

Gene Wiki entry for ABLIM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABLIM1 Gene

Genomics for ABLIM1 Gene

Regulatory Elements for ABLIM1 Gene

Genomic Location for ABLIM1 Gene

Chromosome:
10
Start:
114,431,110 bp from pter
End:
114,821,643 bp from pter
Size:
390,534 bases
Orientation:
Minus strand

Genomic View for ABLIM1 Gene

Genes around ABLIM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABLIM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABLIM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABLIM1 Gene

Proteins for ABLIM1 Gene

  • Protein details for ABLIM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14639-ABLM1_HUMAN
    Recommended name:
    Actin-binding LIM protein 1
    Protein Accession:
    O14639
    Secondary Accessions:
    • A6NI16
    • A6NJ06
    • A8MXA9
    • B3KVH2
    • Q15039
    • Q5JVV1
    • Q5JVV2
    • Q5T6N2
    • Q5T6N3
    • Q5T6N5
    • Q68CQ9
    • Q9BUP1

    Protein attributes for ABLIM1 Gene

    Size:
    778 amino acids
    Molecular mass:
    87688 Da
    Quaternary structure:
    • Binds F-actin. Interacts with ABRA.
    SequenceCaution:
    • Sequence=BAA06681.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ABLIM1 Gene

neXtProt entry for ABLIM1 Gene

Proteomics data for ABLIM1 Gene at MOPED

Post-translational modifications for ABLIM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ABLIM1 Gene

Domains & Families for ABLIM1 Gene

Gene Families for ABLIM1 Gene

Protein Domains for ABLIM1 Gene

Graphical View of Domain Structure for InterPro Entry

O14639

UniProtKB/Swiss-Prot:

ABLM1_HUMAN :
  • Contains 1 HP (headpiece) domain.
Domain:
  • Contains 1 HP (headpiece) domain.
  • Contains 4 LIM zinc-binding domains.
genes like me logo Genes that share domains with ABLIM1: view

Function for ABLIM1 Gene

Molecular function for ABLIM1 Gene

UniProtKB/Swiss-Prot Function:
May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance.
genes like me logo Genes that share phenotypes with ABLIM1: view

Animal Model Products

miRNA for ABLIM1 Gene

miRTarBase miRNAs that target ABLIM1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABLIM1 Gene

Localization for ABLIM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABLIM1 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with the cytoskeleton. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABLIM1 Gene COMPARTMENTS Subcellular localization image for ABLIM1 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for ABLIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ABLIM1: view

Pathways & Interactions for ABLIM1 Gene

genes like me logo Genes that share pathways with ABLIM1: view

Pathways by source for ABLIM1 Gene

1 KEGG pathway for ABLIM1 Gene
1 Qiagen pathway for ABLIM1 Gene

Gene Ontology (GO) - Biological Process for ABLIM1 Gene

None

No data available for SIGNOR curated interactions for ABLIM1 Gene

Drugs & Compounds for ABLIM1 Gene

No Compound Related Data Available

Transcripts for ABLIM1 Gene

mRNA/cDNA for ABLIM1 Gene

(40) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ABLIM1 Gene

Actin binding LIM protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABLIM1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - -
SP4: - - - - -
SP5: - -
SP6: -
SP7:
SP8: -
SP9:

ExUns: 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ABLIM1 Gene

GeneLoc Exon Structure for
ABLIM1
ECgene alternative splicing isoforms for
ABLIM1

Expression for ABLIM1 Gene

mRNA expression in normal human tissues for ABLIM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABLIM1 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.8), Brain - Cerebellar Hemisphere (x5.0), and Brain - Cerebellum (x4.1).

Protein differential expression in normal tissues from HIPED for ABLIM1 Gene

This gene is overexpressed in Cervix (17.7) and Heart (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ABLIM1 Gene



SOURCE GeneReport for Unigene cluster for ABLIM1 Gene Hs.438236

mRNA Expression by UniProt/SwissProt for ABLIM1 Gene

O14639-ABLM1_HUMAN
Tissue specificity: Detected in liver, heart, skeletal muscle, brain and retina, where it is concentrated in the inner segment and in the outer plexiform layers.
genes like me logo Genes that share expression patterns with ABLIM1: view

Protein tissue co-expression partners for ABLIM1 Gene

Primer Products

In Situ Assay Products

Orthologs for ABLIM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ABLIM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ABLIM1 35
  • 90.27 (n)
  • 94.13 (a)
ABLIM1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABLIM1 35
  • 90.87 (n)
  • 92.54 (a)
ABLIM1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ablim1 35
  • 87.8 (n)
  • 91.75 (a)
Ablim1 16
Ablim1 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ABLIM1 35
  • 99.57 (n)
  • 99.87 (a)
ABLIM1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ablim1 35
  • 86.28 (n)
  • 89.29 (a)
oppossum
(Monodelphis domestica)
Mammalia ABLIM1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABLIM1 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves ABLIM1 35
  • 84.3 (n)
  • 93.04 (a)
ABLIM1 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABLIM1 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100170541 35
  • 77.54 (n)
  • 83.96 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.28513 35
zebrafish
(Danio rerio)
Actinopterygii ablim1a 35
  • 73.39 (n)
  • 77.66 (a)
ablim1a 36
  • 71 (a)
OneToMany
ablim1b 36
  • 65 (a)
OneToMany
Species with no ortholog for ABLIM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABLIM1 Gene

ENSEMBL:
Gene Tree for ABLIM1 (if available)
TreeFam:
Gene Tree for ABLIM1 (if available)

Paralogs for ABLIM1 Gene

Paralogs for ABLIM1 Gene

genes like me logo Genes that share paralogs with ABLIM1: view

Variants for ABLIM1 Gene

Sequence variations from dbSNP and Humsavar for ABLIM1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs11593544 - 114,468,192(+) TGATG(G/T)AGTAG reference, missense
rs7091419 - 114,444,053(+) GTAGC(A/C/G)ACTGG reference, missense
rs217185 -- 114,727,282(-) TTGAA(A/G)TTTTA intron-variant
rs217186 -- 114,727,000(-) CATGG(G/T)TTCAC intron-variant
rs217187 -- 114,721,993(-) tacac(A/G)tgcaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABLIM1 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
esv2676795 CNV Deletion 23128226
esv26785 CNV Loss 19812545
esv2741184 CNV Deletion 23290073
nsv528140 CNV Loss 19592680

Variation tolerance for ABLIM1 Gene

Residual Variation Intolerance Score: 64.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.31; 62.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABLIM1 Gene

HapMap Linkage Disequilibrium report
ABLIM1
Human Gene Mutation Database (HGMD)
ABLIM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABLIM1 Gene

Disorders for ABLIM1 Gene

Relevant External Links for ABLIM1

Genetic Association Database (GAD)
ABLIM1
Human Genome Epidemiology (HuGE) Navigator
ABLIM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABLIM1

No disorders were found for ABLIM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABLIM1 Gene

Publications for ABLIM1 Gene

  1. Molecular characterization of abLIM, a novel actin-binding and double zinc finger protein. (PMID: 9245787) Roof D.J. … Li T. (J. Cell Biol. 1997) 2 3 4 23 67
  2. Limatin (LIMAB1), an actin-binding LIM protein, maps to mouse chromosome 19 and human chromosome 10q25, a region frequently deleted in human cancers. (PMID: 9417918) Kim A.C. … Chishti A.H. (Genomics 1997) 3 23
  3. ABLIM1 splicing is abnormal in skeletal muscle of patients with DM1 and regulated by MBNL, CELF and PTBP1. (PMID: 25403273) Ohsawa N. … Ishiura S. (Genes Cells 2015) 3
  4. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  5. Luzp4 defines a new mRNA export pathway in cancer cells. (PMID: 25662211) Viphakone N. … Wilson S.A. (Nucleic Acids Res. 2015) 3

Products for ABLIM1 Gene

Sources for ABLIM1 Gene

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