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Aliases for ABLIM1 Gene

Aliases for ABLIM1 Gene

  • Actin Binding LIM Protein 1 2 3
  • LIMAB1 3 4 6
  • Actin-Binding LIM Protein Family Member 1 3 4
  • LIMATIN 3 4
  • AbLIM-1 3 4
  • ABLIM 3 4
  • Actin-Binding Double-Zinc-Finger Protein 3
  • Actin-Binding Double Zinc Finger Protein 4
  • Actin-Binding LIM Protein 1 3
  • KIAA0059 4

External Ids for ABLIM1 Gene

Previous Symbols for ABLIM1 Gene

  • LIMAB1
  • ABLIM

Summaries for ABLIM1 Gene

Entrez Gene Summary for ABLIM1 Gene

  • This gene encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. The protein encoded by this gene could mediate such interactions between actin filaments and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABLIM1 Gene

ABLIM1 (Actin Binding LIM Protein 1) is a Protein Coding gene. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include actin binding. An important paralog of this gene is AJUBA.

UniProtKB/Swiss-Prot for ABLIM1 Gene

  • May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance.

Gene Wiki entry for ABLIM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABLIM1 Gene

Genomics for ABLIM1 Gene

Genomic Location for ABLIM1 Gene

Start:
114,431,110 bp from pter
End:
114,768,609 bp from pter
Size:
337,500 bases
Orientation:
Minus strand

Genomic View for ABLIM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABLIM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABLIM1 Gene

Regulatory Elements for ABLIM1 Gene

Proteins for ABLIM1 Gene

  • Protein details for ABLIM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14639-ABLM1_HUMAN
    Recommended name:
    Actin-binding LIM protein 1
    Protein Accession:
    O14639
    Secondary Accessions:
    • A6NI16
    • A6NJ06
    • A8MXA9
    • B3KVH2
    • Q15039
    • Q5JVV1
    • Q5JVV2
    • Q5T6N2
    • Q5T6N3
    • Q5T6N5
    • Q68CQ9
    • Q9BUP1

    Protein attributes for ABLIM1 Gene

    Size:
    778 amino acids
    Molecular mass:
    87688 Da
    Quaternary structure:
    • Binds F-actin. Interacts with ABRA.
    SequenceCaution:
    • Sequence=BAA06681.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ABLIM1 Gene

neXtProt entry for ABLIM1 Gene

Proteomics data for ABLIM1 Gene at MOPED

Post-translational modifications for ABLIM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ABLIM1 Gene

Domains for ABLIM1 Gene

Protein Domains for ABLIM1 Gene

UniProtKB/Swiss-Prot:

ABLM1_HUMAN
Domain:
  • Contains 1 HP (headpiece) domain.:
    • O14639
  • Contains 4 LIM zinc-binding domains.:
    • O14639
genes like me logo Genes that share domains with ABLIM1: view

No data available for Gene Families for ABLIM1 Gene

Function for ABLIM1 Gene

Molecular function for ABLIM1 Gene

UniProtKB/Swiss-Prot Function: May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance.

Gene Ontology (GO) - Molecular Function for ABLIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ABLIM1: view

Phenotypes for ABLIM1 Gene

genes like me logo Genes that share phenotypes with ABLIM1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ABLIM1 Gene

Localization for ABLIM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABLIM1 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with the cytoskeleton. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABLIM1 Gene COMPARTMENTS Subcellular localization image for ABLIM1 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for ABLIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 22684256
GO:0005737 cytoplasm IEA --
GO:0015629 actin cytoskeleton TAS 9245787
GO:0030027 lamellipodium IDA 22684256
genes like me logo Genes that share ontologies with ABLIM1: view

Pathways for ABLIM1 Gene

genes like me logo Genes that share pathways with ABLIM1: view

Pathways by source for ABLIM1 Gene

1 Qiagen pathway for ABLIM1 Gene
1 KEGG pathway for ABLIM1 Gene

Gene Ontology (GO) - Biological Process for ABLIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IEA --
GO:0007411 axon guidance TAS --
GO:0007601 visual perception TAS 9245787
GO:0009887 organ morphogenesis TAS 9245787
GO:0030032 lamellipodium assembly IMP 22684256
genes like me logo Genes that share ontologies with ABLIM1: view

Transcripts for ABLIM1 Gene

mRNA/cDNA for ABLIM1 Gene

(21) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ABLIM1 Gene

Actin binding LIM protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABLIM1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - -
SP4: - - - - -
SP5: - -
SP6: -
SP7:
SP8: -
SP9:

ExUns: 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ABLIM1 Gene

GeneLoc Exon Structure for
ABLIM1
ECgene alternative splicing isoforms for
ABLIM1

Expression for ABLIM1 Gene

mRNA expression in normal human tissues for ABLIM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABLIM1 Gene

This gene is overexpressed in Heart - Left Ventricle (5.8), Brain - Cerebellar Hemisphere (5.0), and Brain - Cerebellum (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ABLIM1 Gene

SOURCE GeneReport for Unigene cluster for ABLIM1 Gene Hs.438236

mRNA Expression by UniProt/SwissProt for ABLIM1 Gene

O14639-ABLM1_HUMAN
Tissue specificity: Detected in liver, heart, skeletal muscle, brain and retina, where it is concentrated in the inner segment and in the outer plexiform layers.
genes like me logo Genes that share expressions with ABLIM1: view

Orthologs for ABLIM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ABLIM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABLIM1 36
  • 99.57 (n)
  • 99.87 (a)
ABLIM1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ABLIM1 36
  • 90.27 (n)
  • 94.13 (a)
ABLIM1 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABLIM1 36
  • 90.87 (n)
  • 92.54 (a)
ABLIM1 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ablim1 36
  • 87.8 (n)
  • 91.75 (a)
Ablim1 16
Ablim1 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABLIM1 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABLIM1 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ablim1 36
  • 86.28 (n)
  • 89.29 (a)
chicken
(Gallus gallus)
Aves ABLIM1 36
  • 84.3 (n)
  • 93.04 (a)
ABLIM1 37
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABLIM1 37
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.28513 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100170541 36
  • 77.54 (n)
  • 83.96 (a)
zebrafish
(Danio rerio)
Actinopterygii ablim1a 36
  • 73.39 (n)
  • 77.66 (a)
ablim1a 37
  • 71 (a)
OneToMany
ablim1b 37
  • 65 (a)
OneToMany
Species with no ortholog for ABLIM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABLIM1 Gene

ENSEMBL:
Gene Tree for ABLIM1 (if available)
TreeFam:
Gene Tree for ABLIM1 (if available)

Paralogs for ABLIM1 Gene

Paralogs for ABLIM1 Gene

genes like me logo Genes that share paralogs with ABLIM1: view

Variants for ABLIM1 Gene

Sequence variations from dbSNP and Humsavar for ABLIM1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs6646 -- 114,431,415(-) GAAGG(C/T)GTGTG utr-variant-3-prime
rs10978 -- 114,435,840(-) TATTA(A/T)GTAGC utr-variant-3-prime
rs217185 -- 114,727,282(-) TTGAA(A/G)TTTTA intron-variant
rs217190 -- 114,701,663(-) TGTTT(C/T)GTGTA intron-variant
rs217191 -- 114,701,925(-) CTACA(C/T)CCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABLIM1 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
esv2676795 CNV Deletion 23128226
esv26785 CNV Loss 19812545
esv2741184 CNV Deletion 23290073
nsv528140 CNV Loss 19592680

Relevant External Links for ABLIM1 Gene

HapMap Linkage Disequilibrium report
ABLIM1
Human Gene Mutation Database (HGMD)
ABLIM1

Disorders for ABLIM1 Gene

(1) Novoseek inferred disease relationships for ABLIM1 Gene

Disease -log(P) Hits PubMed IDs
cancer 0 2

Relevant External Links for ABLIM1

Genetic Association Database (GAD)
ABLIM1
Human Genome Epidemiology (HuGE) Navigator
ABLIM1
genes like me logo Genes that share disorders with ABLIM1: view

No data available for UniProtKB/Swiss-Prot for ABLIM1 Gene

Publications for ABLIM1 Gene

  1. Molecular characterization of abLIM, a novel actin-binding and double zinc finger protein. (PMID: 9245787) Roof D.J. … Li T. (J. Cell Biol. 1997) 2 3 4 23
  2. Limatin (LIMAB1), an actin-binding LIM protein, maps to mouse chromosome 19 and human chromosome 10q25, a region frequently deleted in human cancers. (PMID: 9417918) Kim A.C. … Chishti A.H. (Genomics 1997) 3 23
  3. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N. … Tabata S. (DNA Res. 1994) 3 4
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for ABLIM1 Gene

Sources for ABLIM1 Gene

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