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ABL2 Gene

protein-coding GIFtS: 65

GC01M177339

v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ABLL)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ABLL ^², ³, ⁵
ARG ^¹, ², ³, ⁵
Abelson-related ^²
EC 2.7.10.2 ^³
FLJ22224 ^²
FLJ31718 ^²
FLJ41441 ^²
OTTHUMP00000033139 ^²

Descriptions
Abelson murine leukemia viral (v-abl) oncogene homolog 2 ^²
Abelson murine leukemia viral oncogene homolog 2 ^³
Abelson-related gene protein ^³
Tyrosine kinase ARG ^³
arg tyrosine kinase ^²
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) ^²

External Ids
HGNC: 77¹
Entrez Gene: 27²
UniProtKB: P42684³
Ensembl: ENSG00000143322⁷

Search outside databases for aliases for ABL2 gene

Previous GC identifers: GC01M176601 GC01M174505 GC01M175616 GC01M176316 GC01M175804

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for ABL2:

This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinase. The

protein is highly similar to the ABL1 protein, including the tyrosine kinase, SH2 and SH3 domains,

and has a role in cytoskeletal rearrangements by its C-terminal F-actin- and microtubule-binding

sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation

with the ETV6 gene in leukemia. Multiple alternatively spliced transcript variants encoding

different protein isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: ABL2_HUMAN, P42684

Function: Regulates cytoskeleton remodeling during cell differentiation, cell division and cell

adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other

proteins controlling cytoskeleton dynamics

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ABL2 gene

Entrez Gene cytogenetic band: 1q24-q25 Ensembl cytogenetic band: 1q25.2 HGNC cytogenetic band: 1q25.2

ABL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M177339: (about GC identifiers)

Start:	177,335,085 bp from pter
End:	177,465,390 bp from pter
Size:	130,306 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ABL2_HUMAN, P42684 (See protein sequence)

Recommended Name: Tyrosine-protein kinase ABL2

Size: 1182 amino acids; 128343 Da

Cofactor: Magnesium or manganese

Subcellular location: Cytoplasm, cytoskeleton

PDB structure from and Proteopedia :

2ECD (3D)

3GVU (3D)

Secondary accessions: A0M8X0 Q5T0X6 Q5W0C5 Q6NZY6 Q7Z301

Alternative splicing: 4 isoforms: P42684-1 P42684-2 P42684-3 P42684-4

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (5 alternative transcripts):

NP_001093578.1 NP_001129472.1 NP_001129473.1 NP_005149.3 NP_009298.1

ENSEMBL proteins:

ENSP00000356595 ENSP00000386152 ENSP00000339209 ENSP00000375897

Human Recombinant Proteins

	Invitrogen human recombinant proteins for ABL2
	Millipore Purified and/or Recombinant ABL2 Protein
	Sigma-Aldrich Proteins for ABL2
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ABL2)
	Human Recombinant Proteins from Abnova (ABL2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005856	cytoskeleton	IEA	--

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Antibodies for ABL2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ABL2
	Sigma-Aldrich Antibodies for ABL2
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for ABL2
	Antibodies from Abcam (ABL2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ABL2)
	Novus Biologicals Antibodies for ABL2

Assays for ABL2:

	Invitrogen Assays for ABL2
	Millipore Kits and Assays for the Analysis of ABL2
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P42684

ProtoNet protein and cluster: P42684

3 Blocks protein families:

IPB000980 SH2 domain signature

IPB001452 SH3 domain signature

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: ABL2_HUMAN, P42684

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 SH2 domain

Similarity: Contains 1 SH3 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABL2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABL2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_007314

Applied Biosystems Silencer® siRNAs for ABL2

Sigma-Aldrich siRNA and siRNA Panels for ABL2

Sigma-Aldrich shRNA Panels and shRNA for ABL2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ABL2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_001100108
Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_001100108
untagged cDNA clones in CMV expression vector (see all 6): NM_001100108

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_007314

UniProtKB/Swiss-Prot: ABL2_HUMAN, P42684

Function: Regulates cytoskeleton remodeling during cell differentiation, cell division and cell

adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other

proteins controlling cytoskeleton dynamics

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme regulation: Stabilized in the inactive form by an association between the SH3 domain and the

SH2-TK linker region, interactions of the amino-terminal cap, and contributions from an

amino-terminal myristoyl group and phospholipids. Activated by autophosphorylation as well as by

SRC-family kinase-mediated phosphorylation. Activated by RIN1 binding to the SH2 and SH3 domains.

Inhibited by imatinib mesylate (Gleevec) which is used for the treatment of chronic myeloid

leukemia (CML)

Enzyme Number (IUBMB): EC 2.7.10.2

Genatlas biochemistry entry for ABL2:

Abelson murine leukemia viral (v-abl) oncogene homolog 2

10 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Abl2):

	behavior/neurological	cellular	growth/size	hearing/vestibular/ear
homeostasis/metabolism	lethality-postnatal	lethality-prenatal/perinatal	nervous system	reproductive system

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0000287	magnesium ion binding	IDA	15886098
GO:0004715	non-membrane spanning protein tyrosine kinase activity	IEA	--
GO:0005515	protein binding	IPI	15886098 17474147
GO:0005524	ATP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for ABL2 (Your Favorite Gene powered by Ingenuity)

PDGF Signaling

GeneDecks ABL2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ABL2

5/28 Interacting proteins for ABL2 (ENSP00000356595³ P42684^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 28 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CRK	P46108¹	STRING (score=.992) EBI-1102694, EBI-886
HRAS	P01112²	STRING (score=.769) MINT-59461 MINT-59462
RIN1	Q13671¹^,²	STRING (score=.991) EBI-1102694, EBI-366017 MINT-59459 MINT-59458 EBI-1102694, EBI-366017 MINT-59459 MINT-59458
FYN	P06241¹	EBI-1102694, EBI-515315
GRB2	P62993¹	EBI-1102694, EBI-401755

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006464	protein modification process	TAS	2198571
GO:0007155	cell adhesion	IEA	--
GO:0007165	signal transduction	TAS	2198571
GO:0018108	peptidyl-tyrosine phosphorylation	IDA	15886098
GO:0051353	positive regulation of oxidoreductase activity	IDA	12893824

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ABL2
2 Novoseek chemical compound relationships for ABL2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	69.78	37	17306540 (3), 10590083 (2), 12950161 (2), 12680214 (2) (see all 26)
oxygen	0.00	1	12569093 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABL2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABL2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_007314

Sigma-Aldrich siRNA and siRNA Panels for ABL2

Sigma-Aldrich shRNA Panels and shRNA for ABL2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001100108 NM_001136000 NM_001136001 NM_005158 NM_007314

REFSEQ mRNAs for ABL2 gene (5 alternative transcripts):

NM_001100108.1 NM_001136000.1 NM_001136001.1 NM_005158.3 NM_007314.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001100108 NM_001136000 NM_001136001 NM_005158 NM_007314

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_001100108
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_001100108
                                 untagged cDNA clones in CMV expression vector (see all 6): NM_001100108

Additional cDNA sequence:

AK025877.1 AK056280.1 AK225255.1 AK309549.1 AK311045.1 BC065912.1 BX538317.1 FJ542283.1

FJ542284.1 FJ542285.1 FJ542286.1 M35296.1

12 DOTS entries:

DT.100754808 DT.100755319 DT.423211 DT.306356 DT.102826726 DT.91661488 DT.121446659 DT.121446570

DT.121446577 DT.95152104 DT.95127239 DT.97818073

24/181 AceView cDNA sequences (see all 181 ):

BC065912 AA371305 BQ227288 M35296 BM676754 NM_005158 AW613399 BM466684

BQ672160 BQ674289 F12791 H80903 BU634226 CA447716 NM_007314 BU169285

Z43953 CD369364 BQ678351 BQ216804 AA378992 F06302 BM719893 CD367407

highest scoring ESTs for ABL2:

M35296 AA622941 AI205337 AL710170 AW992442 AW997225 AW999983 BC065912 BE465639 BE775191

Unigene Cluster for ABL2:

V-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)

Hs.159472 [show with all ESTs]

Unigene Representative Sequence: NM_007314

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000367623 ENST00000408940 ENST00000344730 ENST00000392043

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ABL2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ABL2

¹ / ² / ³

10 probe-sets matching ABL2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
62244_r_at²^{, 3}	U95-C	1	1.00	1.00	0.08	1.12	W01799	0.40	1.00	0.76	1
1084_at²^{, 3}	U95-A	1	1.00	1.00	0.41	0.38	M35296	1.00	1.00	1.00	1
62243_i_at²^{, 3}	U95-C	1	1.00	1.00	0.75	0.62	W01799	0.40	1.00	0.76	1
53857_at²^{, 3}	U95-B	1	1.00	1.00	0.23	1.30	H09392	0.20	1.00	0.72	1
231907_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AK025877	0.20	1.00	0.72	1
206411_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_007314	0.60	1.00	0.82	1
226893_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW173164	0.20	1.00	0.72	1
231907_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206411_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
226893_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ABL2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CGGATTCAAT

SOURCE GeneReport for Unigene cluster: Hs.159472
Expression variation in blood from EXPOLDB for ABL2
UniProtKB/Swiss-Prot: ABL2_HUMAN, P42684
Tissue specificity: Widely expressed

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ABL2 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ABL2¹	--	v-abl Abelson murine leukemia viral oncogene homolog more	94.59(n) 98.21(a)	480052 XM_855602.1 XP_860695.1
chimpanzee (Pan troglodytes)	ABL2¹	--	v-abl Abelson murine leukemia viral oncogene homolog more	99.69(n) 99.75(a)	457552 XM_001156169.1 XP_001156169.1
cow (Bos taurus)	ABL2¹	--	v-abl Abelson murine leukemia viral oncogene homolog more	93.23(n) 96.11(a)	511845 XM_001253284.1 XP_001253285.1
rat (Rattus norvegicus)	Abl2¹	--	v-abl Abelson murine leukemia viral oncogene homolog more	90.74(n) 91.27(a)	304883 XM_222768.4 XP_222768.4
mouse (Mus musculus)	Abl2^{1, 5}	1 (82.10 cM)⁵	v-abl Abelson murine leukemia viral oncogene homolog more^{1, 5}	90.62(n)¹ 94.92(a)¹	11352¹ NM_009595.2¹ NP_033725.2¹ AA416345⁵ AA536808⁵ (see all 20)

About this table Species with no ortholog for ABL2

ENSEMBL Gene Tree for ABL2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ABL2 gene

ABL1² FRK²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/839 NCBI SNPs in ABL2 are shown (see all 839 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 253)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3210839^1,2	A,C,F,H,O	177336052(-)	`CCAGGA/GGACAG`	4	--	ut3¹		6	EA WA NA	440
	rs2791941^1,2	A,C,F,H	177379058(-)	`ACTTAC/TATTTT`	3	--	int¹ ng3¹		5	EA EU WA	1914
	rs9662858^1,2	A,C,F,H	177335474(+)	`TTTAAG/AGAATT`	4	--	ut3¹		11	NA EU EA WA	924
	rs2636266^1,2	A,C,F,H	177466275(+)	`AAAATA/GTATAT`	1	--	ng3¹		9	NS EU EA WA	590
	rs3813643^1,2	A,C,F,H	177336957(+)	`AATCTG/CCAAGG`	4	--	ut3¹		11	EU EA WA NA	980
	rs10913692^1,2	A,C,F,H	177341492(+)	`TTCTTT/GCCAAT`	4	--	ut3¹ trp³		12	NA NS EU EA WA	752
	rs3829794^1,2	A,C,F,H	177339351(+)	`CCCCAT/CTGAAT`	4	--	ut3¹		7	NA EU EA WA	560
	rs1325194^1,2	A,C,F,H	177338541(-)	`ATTGCA/CTTGGT`	4	--	ut3¹		7	NA EU EA WA	562
	rs4651013^1,2	A,C,F,H	177339589(+)	`GGCTCT/CGCCAC`	4	--	ut3¹		4	EU EA WA	418
	rs4651014^1,2	A,C,F,H	177339662(+)	`ATAAAG/CCAAAG`	4	--	ut3¹		4	EU EA WA	420

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HapMap Linkage Disequilibrium images for ABL2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 164690

4 Novoseek disease relationships for ABL2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia	41.05	3	10706884 (1), 17211892 (1), 15765532 (1)
colorectal cancer	3.86	1	12680214 (1)
cancer	0.00	1	12680214 (1)
carcinoma	0.00	2	10521789 (1), 15765532 (1)

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Human Genome Epidemiology Navigator: ABL2 (2 documents)
Tumor Gene Database: ABL2

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/72 PubMed articles for ABL2 gene (see all 72 ):

A novel human gene closely related to the abl proto-oncogene. (PubMed id 3787260)^{2, 3, 4} Kruh G.D.... Aaronson S.A. (1986)
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)^{3, 4} Wissing J.... Daub H. (2007)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration. (PubMed id 15886098)^{3, 4} Hu H.... Colicelli J. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. (PubMed id 12522270)^{3, 4} Salomon A.R.... Peters E.C. (2003)
The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases. (PubMed id 2198571)^{3, 4} Kruh G.D.... Aaronson S.A. (1990)
Catalase activity is regulated by c-Abl and Arg in the oxidative stress response. (PubMed id 12777400)^{1, 3} Cao C....Kufe D. (2003)
Eight full-length abelson related gene (Arg) isoforms are constitutively expressed in caki-1 cell line and cell distribution of two isoforms has been analyzed after transfection. (PubMed id 18810762)^{1, 3} Bianchi C....Perego R.A. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 27	HGNC: 77	AceView: ABL2	Ensembl:ENSG00000143322	euGenes: HUgn27
ECgene: ABL2	H-InvDB: ABL2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for ABL2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/abl2/
CGP resequencing studies	http://www.sanger.ac.uk/perl/genetics/CGP/cgp_viewer?action=gene&ln=ABL2

Licensable Technologies for ABL2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ABL2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ABL2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ABL2		Antibodies for ABL2
	Explore super-pooled esiRNAs		Proteins for ABL2
	Lentivirus-delivered shRNAs for ABL2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ABL2)
	Antibodies (ABL2)
	Chimera RNAi (ABL2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for ABL2

	Recombinant Proteins (ABL2)
	Antibodies (ABL2)

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Search Tocris compounds for ABL2

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Antibodies for ABL2

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ABL2 Gene at Home site.
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ABL2 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for ABL2

Summaries
for ABL2

Genomic Location
for ABL2

Proteins
for ABL2

Protein Domains/
Families
for ABL2

Gene Function
for ABL2

Pathways & Interactions
for ABL2

Drugs & Compounds
for ABL2

Transcripts
for ABL2

Expression
for ABL2

Orthologs
for ABL2

Paralogs
for ABL2

SNPs/Variants
for ABL2

Disorders & Mutations
for ABL2

Medical News
for ABL2

Publications
for ABL2

Search for ABL2

Genome Databases showing ABL2

Other Databases showing ABL2

Specialized Databases showing ABL2

Licensable Technologies
for ABL2

Services
for ABL2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ABL2 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor ABL2

Summariesfor ABL2

Genomic Locationfor ABL2

Proteinsfor ABL2

Protein Domains/Familiesfor ABL2

Gene Functionfor ABL2

Pathways & Interactionsfor ABL2

Drugs & Compoundsfor ABL2

Transcriptsfor ABL2

Expression for ABL2

Orthologsfor ABL2

Paralogsfor ABL2

SNPs/Variantsfor ABL2

Disorders & Mutationsfor ABL2

Medical Newsfor ABL2

Publicationsfor ABL2

Search for ABL2

Genome Databases showing ABL2

Other Databases showing ABL2

Specialized Databases showing ABL2

Licensable Technologiesfor ABL2

Servicesfor ABL2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ABL2

Summaries
for ABL2

Genomic Location
for ABL2

Proteins
for ABL2

Protein Domains/
Families
for ABL2

Gene Function
for ABL2

Pathways & Interactions
for ABL2

Drugs & Compounds
for ABL2

Transcripts
for ABL2

Expression
for ABL2

Orthologs
for ABL2

Paralogs
for ABL2

SNPs/Variants
for ABL2

Disorders & Mutations
for ABL2

Medical News
for ABL2

Publications
for ABL2

Licensable Technologies
for ABL2

Services
for ABL2