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ABL2 Gene

protein-coding   GIFtS: 68
GCID: GC01M179068

C-Abl Oncogene 2, Non-Receptor Tyrosine Kinase

(Previous names: v-abl Abelson murine leukemia viral oncogene homolog 2 (arg,...)
(Previous symbol: ABLL)
  See ABL2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
C-Abl Oncogene 2, Non-Receptor Tyrosine Kinase1 2     EC 2.7.10.23 8
ABLL1 2 3 5     Abelson-Related Gene1
ARG2 3 5     V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 2 (Arg,
Abelson-Related Gene)1
V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 21 2     Abelson Tyrosine-Protein Kinase 22
Abelson-Related Gene Protein2 3     Abelson Murine Leukemia Viral Oncogene Homolog 23
Tyrosine-Protein Kinase ARG2 3     EC 2.7.108

External Ids:    HGNC: 771   Entrez Gene: 272   Ensembl: ENSG000001433227   OMIM: 1646905   UniProtKB: P426843   

Export aliases for ABL2 gene to outside databases

Previous GC identifers: GC01M176601 GC01M174505 GC01M175616 GC01M176316 GC01M175804 GC01M177339 GC01M150296


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ABL2 Gene:
This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly
similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role
in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is
expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in
leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found
for this gene. (provided by RefSeq, Nov 2009)

GeneCards Summary for ABL2 Gene:
ABL2 (c-abl oncogene 2, non-receptor tyrosine kinase) is a protein-coding gene. Diseases associated with ABL2 include leukemia, acute myeloid, with eosinophilia, and leukemia. GO annotations related to this gene include protein tyrosine kinase activity and magnesium ion binding. An important paralog of this gene is FRK.

UniProtKB/Swiss-Prot: ABL2_HUMAN, P42684
Function: Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell
growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and
adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins
controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and
TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its
F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of
key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of
ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it
inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are
involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating
proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during
infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple
purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator
through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1

Gene Wiki entry for ABL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ABL2 gene promoter:
         Nkx3-1   Nkx3-1 v4   GATA-3   Brachyury   Nkx3-1 v1   Meis-1b   Nkx3-1 v2   Nkx3-1 v3   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): ABL2 promoter sequence
   Search Chromatin IP Primers for ABL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ABL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.2   Ensembl cytogenetic band:  1q25.2   HGNC cytogenetic band: 1q25.2

ABL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABL2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M179068:  view genomic region     (about GC identifiers)

Start:
179,068,462 bp from pter      End:
179,198,819 bp from pter
Size:
130,358 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ABL2_HUMAN, P42684 (See protein sequence)
Recommended Name: Abelson tyrosine-protein kinase 2  
Size: 1182 amino acids; 128343 Da
Cofactor: Magnesium or manganese
Subunit: Interacts with PSMA7. Interacts with CTTN
Sequence caution: Sequence=CAD98092.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Selected PDB 3D structures from and Proteopedia for ABL2 (see all 7):
2ECD (3D)        2KK1 (3D)        2XYN (3D)        3GVU (3D)        3HMI (3D)        3ULR (3D)    
Secondary accessions: A0M8X0 B7UEF2 B7UEF3 B7UEF4 B7UEF5 Q5T0X6 Q5W0C5 Q6NZY6 Q7Z301
Alternative splicing: 9 isoforms:  P42684-1   P42684-2   P42684-3   P42684-4   P42684-5   P42684-6   P42684-7   P42684-10   
P42684-8   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ABL2: NX_P42684

Explore proteomics data for ABL2 at MOPED

Post-translational modifications: 

  • Phosphorylated at Tyr-261 by ABL1 in response to oxidative stress. Phosphorylated by PDGFRB (By similarity)1
  • Polyubiquitinated. Polyubiquitination of ABL2 leads to degradation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ABL2 (P42684) (see all 17)
     RDLAARN  LFVALYD  PADRPSF  ELVHHHS 


    See ABL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_001129472.1  NP_001129473.1  NP_001161708.1  NP_001161709.1  NP_001161710.1  NP_001161711.1  NP_005149.4  NP_009298.1  

    ENSEMBL proteins: 
     ENSP00000427562   ENSP00000339209   ENSP00000423578   ENSP00000426831   ENSP00000356595  
     ENSP00000423413   ENSP00000424697   ENSP00000375897   ENSP00000386152  
    Reactome Protein details: P42684

    ABL2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant ABL2 Protein
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    Novus Biologicals ABL2 Proteins
    Novus Biologicals ABL2 Lysates
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    Cloud-Clone Corp. Proteins for ABL2

     
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    ABL2 Antibody Products:

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    Abcam antibodies for ABL2
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    LSBio Antibodies in human, mouse, rat for ABL2

    ABL2 Assay Products:

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    Cloud-Clone Corp. ELISAs for ABL2
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    Search eBioscience for ELISAs for ABL2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: v-abl Abelson murine leukemia viral oncogene homolog 2
    Abl family

    Selected InterPro protein domains (see all 9):
     IPR017441 Protein_kinase_ATP_BS
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR015015 F-actin_binding
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry P42684

    ProtoNet protein and cluster: P42684

    3 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: ABL2_HUMAN, P42684
    Domain: Contains two distinct classes of F-actin-binding domains. Although both can bind F-actin, the 2 are
    required to bundle actin filaments (By similarity)
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with ABL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ABL2_HUMAN, P42684
    Function: Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell
    growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and
    adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins
    controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and
    TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its
    F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of
    key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of
    ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it
    inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are
    involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating
    proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during
    infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple
    purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator
    through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker
    region, interactions of the N-terminal cap, and contributions from an N-terminal myristoyl group and
    phospholipids. Activated by autophosphorylation as well as by SRC-family kinase-mediated phosphorylation.
    Activated by RIN1 binding to the SH2 and SH3 domains. Inhibited by imatinib mesylate (Gleevec) which is used for
    the treatment of chronic myeloid leukemia (CML). Phosphatidylinositol 4,5-bisphosphate (PIP2), a highly abundant
    phosphoinositide known to regulate cytoskeletal and membrane proteins, inhibits the tyrosine kinase activity (By
    similarity)

         Genatlas biochemistry entry for ABL2:
    Abelson murine leukemia viral (v-abl) oncogene homolog 2

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA15886098
    GO:0003785actin monomer binding TAS--
    GO:0004672protein kinase activity TAS2198571
    GO:0004713protein tyrosine kinase activity IDA15886098
    GO:0004715non-membrane spanning protein tyrosine kinase activity TAS--
         
    Find genes that share ontologies with ABL2           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for ABL2:
     Decreased substrate adherent c  Gemcitabine induced cell-death  Increased mitotic index  Increased viability with TRAIL 

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Abl2):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size/body 
     homeostasis/metabolism  mortality/aging  nervous system  reproductive system 

    Find genes that share phenotypes with ABL2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Abl2tm1Ajk for ABL2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ABL2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ABL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ABL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ABL2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ABL2:
    hsa-mir-103a-3p (MIRT027023), hsa-mir-16-5p (MIRT031452), hsa-mir-140-3p (MIRT021668), hsa-mir-92a-3p (MIRT049012)

    Block miRNA regulation of human, mouse, rat ABL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ABL2 (see all 189):
    hsa-miR-106a hsa-miR-199a-3p hsa-miR-146a hsa-miR-605 hsa-miR-128 hsa-miR-3653 hsa-miR-519a hsa-miR-3921
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ABL2

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 8): ABL2 (NM_001136001)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABL2
    Addgene plasmids for ABL2 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ABL2_HUMAN, P42684: Cytoplasm, cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0015629actin cytoskeleton TAS--

    Find genes that share ontologies with ABL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ABL2 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    2Signaling by Robo receptor
    Signaling by Robo receptor
    Role of Abl in Robo-Slit signaling0.00
    3ErbB signaling pathway
    ErbB signaling pathway0.52
    4ERK Signaling
    Molecular Mechanisms of Cancer0.51
    5Allograft rejection
    Viral myocarditis0.40


    Find genes that share SuperPaths with ABL2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ABL2
        G-Protein Signaling through Tubby Protein
    Guidance Cues and Growth Cone Motility
    Molecular Mechanisms of Cancer
    Signaling by Slit

    1 Reactome Pathway for ABL2
        Role of Abl in Robo-Slit signaling


    3 Kegg Pathways  (Kegg details for ABL2):
        ErbB signaling pathway
    Ras signaling pathway
    Viral myocarditis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ABL2
    Interactions:

        GeneGlobe Interaction Network for ABL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ABL2 (P426841, 2, 3 ENSP000003565954) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB3P218601, 2, 3, ENSP000002671014EBI-1102694,EBI-720706 MINT-74450 MINT-74445 MINT-74451 MINT-74452 MINT-74453 MINT-74448 MINT-74446 MINT-74447 MINT-74449 MINT-74454 I2D: score=2 STRING: ENSP00000267101
    EGFRP005331, 2, 3, ENSP000002754934EBI-1102694,EBI-297353 MINT-74436 MINT-74438 MINT-74434 MINT-74437 MINT-74435 MINT-74432 MINT-74433 I2D: score=2 STRING: ENSP00000275493
    ERBB2P046261, 2, 3, ENSP000002695714EBI-1102694,EBI-641062 MINT-74443 MINT-74440 MINT-74444 MINT-74442 MINT-74439 MINT-74441 I2D: score=2 STRING: ENSP00000269571
    RIN1Q136711, 2, 3, ENSP000003104064EBI-1102694,EBI-366017 MINT-59458 MINT-59459 I2D: score=3 STRING: ENSP00000310406
    ABI1Q8IZP01, 2, 3, ENSP000003653124EBI-1102694,EBI-375446 MINT-7908314 MINT-7908442 I2D: score=1 STRING: ENSP00000365312
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS2198571
    GO:0006468protein phosphorylation ----
    GO:0007015actin filament organization ----
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction TAS2198571

    Find genes that share ontologies with ABL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ABL2

    4 HMDB Compounds for ABL2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--

    3 DrugBank Compounds for ABL2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine triphosphate5'-ATP (see all 8)56-65-5targetinhibitor17139284 11752352 17016423
    Dasatinib-- 302962-49-8targetmultitarget20072833 11752352 17016423
    5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE-- --target--10592235

    5 Novoseek inferred chemical compound relationships for ABL2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 68.7 39 17306540 (3), 10590083 (2), 12950161 (2), 12680214 (2) (see all 27)
    imatinib 41.7 8 11290609 (1), 16740702 (1), 15032571 (1)
    h2o2 15 5 12777400 (4)
    retinoic acid 12.1 3 10706884 (1), 9828110 (1)
    oxygen 0 1 12569093 (1)



    Find genes that share compounds with ABL2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ABL2 gene (8 alternative transcripts): 
    NM_001136000.2  NM_001136001.1  NM_001168236.1  NM_001168237.1  NM_001168238.1  NM_001168239.1  NM_005158.4  NM_007314.3  

    Unigene Cluster for ABL2:

    V-abl Abelson murine leukemia viral oncogene homolog 2
    Hs.159472  [show with all ESTs]
    Unigene Representative Sequence: NM_007314
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000502732(uc010pnf.2 uc010png.2 uc001gmj.4 uc010pnh.2)
    ENST00000344730 ENST00000512653 ENST00000504405 ENST00000367623 ENST00000507173
    ENST00000511413 ENST00000392043(uc009wxe.3) ENST00000509520 ENST00000504324(uc001gmk.3 uc009wxf.2)
    ENST00000508127 ENST00000408940(uc001gmg.4 uc001gmi.4 uc010pne.2)

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    hsa-miR-106a hsa-miR-199a-3p hsa-miR-146a hsa-miR-605 hsa-miR-128 hsa-miR-3653 hsa-miR-519a hsa-miR-3921
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    Additional mRNA sequence: 

    AK025877.1 AK056280.1 AK225255.1 AK309549.1 AK311045.1 BC065912.1 BX538317.1 FJ542283.1 
    FJ542284.1 FJ542285.1 FJ542286.1 M35296.1 

    12 DOTS entries:

    DT.100754808  DT.100755319  DT.423211  DT.306356  DT.102826726  DT.91661488  DT.121446659  DT.121446570 
    DT.121446577  DT.95152104  DT.95127239  DT.97818073 

    Selected AceView cDNA sequences (see all 181):

    BC065912 BU634226 BE465639 AA371305 Z43953 H80903 F12791 AA378992 
    AW613399 CD369364 BQ014740 CA447716 BQ678351 F02595 BQ216804 BU169285 
    BQ674289 AI379507 M35296 BM676754 NM_005158 NM_007314 BM466684 BQ672160 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ABL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGATTCAAT
    ABL2 Expression
    About this image


    ABL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Long Bone
     
     Liver (Hepatobiliary System)
    ABL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ABL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.159472

    UniProtKB/Swiss-Prot: ABL2_HUMAN, P42684
    Tissue specificity: Widely expressed

        Custom PCR Arrays for ABL2
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ABL2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Abl21 , 5 v-abl Abelson murine leukemia viral oncogene homolog more5
    v-abl Abelson murine leukemia viral oncogene 2 (arg, more1
    90.62(n)1
    94.92(a)1
      1 (67.71 cM)5
    113521  NM_009595.31  NP_033725.21 
     1565587865 
    chicken
    (Gallus gallus)
    Aves ABL21 v-abl Abelson murine leukemia viral oncogene homolog more 81.05(n)
    88.55(a)
      395410  XM_422269.4  XP_422269.4 
    lizard
    (Anolis carolinensis)
    Reptilia ABL26
    c-abl oncogene 2, non-receptor tyrosine kinase
    84(a)
    1 ↔ 1
    GL343300.1(844869-866104)
    African clawed frog
    (Xenopus laevis)
    Amphibia AF237766.12   -- 75.84(n)    AF237766.1 
    zebrafish
    (Danio rerio)
    Actinopterygii abl21 v-abl Abelson murine leukemia viral oncogene homolog more 67.98(n)
    74.95(a)
      570636  NM_001122705.1  NP_001116177.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Abl3 axon guidance protein tyrosine kinase 72(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea abl-13 Src homology domain 2, Src homology
    domain 3, more
    59(a)
    (best of 19)
      X(10641430-10659377)   --


    ENSEMBL Gene Tree for ABL2 (if available)
    TreeFam Gene Tree for ABL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ABL2 gene
    FRK2  LCK2  BLK2  LYN2  FGR2  PTK62  YES12  HCK2  
    ABL12  SRC2  FYN2  SRMS2  
    17 SIMAP similar genes for ABL2 using alignment to 1 protein entry:     ABL2_HUMAN:
    ABL1    BCR/ABL fusion    GRB2    BMX    FRK    CSK
    TEC    BTK    EPHA2    FYN    GRAP    ITK
    PTK6    FGR    SRMS    MATK    SH2D1A

    Find genes that share paralogs with ABL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ABL2 (see all 2741)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs355765051,2
    C--150310632(+) AAAATT/-AAATA 8 -- int11Minor allele frequency- -:0.00NA 2
    rs676994781,2
    C--150311045(+) TTCAGTGAGCCGAAA
    TCACGTCAC
    /-
    TGAGC
    8 -- int11Minor allele frequency- -:0.50CSA 2
    rs2020994931,2
    --150315701(+) CCTCC-/TCAACTGC 8 -- int10--------
    rs1117522101,2
    C,F--150390320(+) GTGCCC/TGGCCT 5 -- int11Minor allele frequency- T:0.50CSA 2
    rs2007571971,2
    C--150422552(-) AGTTTC/TTNNNN 5 -- int10--------
    rs23069411,2
    C,F,A--150425999(+) CTGAGT/CGGCTG 5 -- ut51 ese37Minor allele frequency- C:0.40NS CSA NA 277
    rs666668281,2
    C--150426114(+) CCCAA-/CGCCGCCG 5 -- cds10--------
    rs289900681,2
    C,F--150426193(-) GCGGGGGGCGGGG
    GGCGGG
    /-
    AGACG
    5 -- us2k15Minor allele frequency- -:0.10NS 136
    rs101574171,2
    C,F--150426210(+) CCCCCG/ACCCCC 5 -- us2k16Minor allele frequency- A:0.03NS NA 120
    rs31223771,2
    C,F,A--150426222(+) GCCCGC/GCAGTC 5 -- us2k1 tfbs37Minor allele frequency- G:0.33NS NA 130

    HapMap Linkage Disequilibrium report for ABL2 (179068462 - 179198819 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ABL2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ABL2
    DNA2.0 Custom Variant and Variant Library Synthesis for ABL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164690    OMIM disorders: --

    2 diseases for ABL2:    
    About MalaCards
    leukemia, acute myeloid, with eosinophilia    leukemia


    Find genes that share disorders with ABL2           About GenesLikeMe

    4 Novoseek inferred disease relationships for ABL2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 38.7 3 10706884 (1), 17211892 (1), 15765532 (1)
    cancer 1.58 1 12680214 (1)
    colorectal cancer 0.318 1 12680214 (1)
    carcinoma 0 2 10521789 (1), 15765532 (1)

    Genetic Association Database (GAD): ABL2
    Human Genome Epidemiology (HuGE) Navigator: ABL2 (6 documents)
    Tumor Gene Database (TGDB): ABL2

    Export disorders for ABL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ABL2 gene, integrated from 10 sources (see all 115):
    (articles sorted by number of sources associating them with ABL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human gene closely related to the abl proto-oncogene. (PubMed id 3787260)1, 2, 3 Kruh G.D.... Aaronson S.A. (Science 1986)
    2. Eight full-length abelson related gene (Arg) isoforms are constitutively expressed in caki-1 cell line and cell distribution of two isoforms has been analyzed after transfection. (PubMed id 18810762)1, 2, 9 Bianchi C.... Perego R.A. (J. Cell. Biochem. 2008)
    3. Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation. (PubMed id 16678104)1, 2, 9 Liu X....Cao C. (Mol. Cell 2006)
    4. Ubiquitination and degradation of the Arg tyrosine kinase is regulated by oxidative stress. (PubMed id 15735735)1, 2, 9 Cao C.... Kufe D. (Oncogene 2005)
    5. A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order. (PubMed id 22036096)1, 4 Ramasamy A....Jarvis D.L. (J. Allergy Clin. Immunol. 2011)
    6. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    9. RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration. (PubMed id 15886098)1, 2 Hu H.... Colicelli J. (Curr. Biol. 2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27 HGNC: 77 AceView: ABL2 Ensembl:ENSG00000143322 euGenes: HUgn27
    ECgene: ABL2 Kegg: 27 H-InvDB: ABL2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ABL2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ABL2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/abl2/
    CGP resequencing studieshttp://www.sanger.ac.uk/perl/genetics/CGP/cgp_viewer?action=gene&ln=ABL2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ABL2 gene:
    Search GeneIP for patents involving ABL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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