ABL2 Gene
protein-coding GIFtS : 66 GCID: GC01 M179068
v-abl Abelson murine leukemia viral oncogene homolog 2 v-abl Abelson murine leukemia viral oncogene homolog 2... ABLL )
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Aliasesfor ABL2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 2 1 2 EC 2.7.10.23 8 ABLL1 2 3 5 V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 2 (Arg, Abelson-RelatedGene)1 ARG1 2 3 5 Abelson Tyrosine-Protein Kinase 22 Abelson-Related Gene Protein2 3 Abelson Murine Leukemia Viral Oncogene Homolog 23 Tyrosine-Protein Kinase ARG2 3 EC 2.7.108
Export aliases for ABL2 gene to outside databases Previous GC identifers: GC01M176601 GC01M174505 GC01M175616 GC01M176316 GC01M175804 GC01M177339 GC01M150296
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Summariesfor ABL2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ABL2 : This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. (provided by RefSeq, Nov 2009) UniProtKB/Swiss-Prot: ABL2_HUMAN, P42684 Function : Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cellgrowth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1 Gene Wiki entry for ABL2
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Genomic Viewsfor ABL2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_004487.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ABL2 gene promoter:Nkx3-1 Nkx3-1 v4 GATA-3 Brachyury Nkx3-1 v1 Meis-1b Nkx3-1 v2 Nkx3-1 v3 Meis-1a Meis-1 Other transcription factors Search SABiosciences Chromatin IP Primers for ABL2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1q25.2 Ensembl cytogenetic band: 1q25.2 HGNC cytogenetic band: 1q25.2 ABL2 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M179068: view genomic region
(about GC identifiers )
Start: 179,068,462 bp from pter End:
179,198,819 bp from pter
Size: 130,358 bases Orientation:
minus strand
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Proteinsfor ABL2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ABL2_HUMAN, P42684 See
protein sequence )Recommended Name: Size : 1182 amino acids; 128343 DaCofactor : Magnesium or manganeseSubunit : Interacts with PSMA7. Interacts with CTTNSubcellular location : Cytoplasm, cytoskeletonSequence caution : Sequence=CAD98092.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;6 PDB 3D structures from :2ECD (3D) 2KK1 (3D) 2XYN (3D) 3GVU (3D) 3HMI (3D) 3ULR (3D) Secondary accessions : A0M8X0 B7UEF2 B7UEF3 B7UEF4 B7UEF5 Q5T0X6 Q5W0C5 Q6NZY6 Q7Z301Alternative splicing : 9 isoforms : P42684-1 P42684-2 P42684-3 P42684-4 P42684-5 P42684-6 P42684-7 P42684-10 P42684-8 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ABL2: NX_P42684 Post-translational modifications:
Phosphorylated at Tyr-261 by ABL1 in response to oxidative stress. Phosphorylated by PDGFRB (By similarity)1 Polyubiquitinated. Polyubiquitination of ABL2 leads to degradation1 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P42684 4/17 DME Specific Peptides for ABL2 (P42684 ) (see all 17 )ABL2 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (8 alternative transcripts): NP_001129472.1 NP_001129473.1 NP_001161708.1 NP_001161709.1 NP_001161710.1 NP_001161711.1 NP_005149.4 NP_009298.1 ENSEMBL proteins: ENSP00000427562 ENSP00000339209 ENSP00000423578 ENSP00000426831 ENSP00000356595 ENSP00000423413 ENSP00000424697 ENSP00000375897 ENSP00000386152 Reactome Protein details: P42684 Human Recombinant Protein Products for ABL2: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing ABL2 Antibody Products: Assay Products for ABL2:
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Protein
Domains /for ABL2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5/9 InterPro domains/families (see all 9 ):
Graphical View of Domain Structure for InterPro Entry P42684 ProtoNet protein and cluster: P42684
3 Blocks protein families : IPB000980 IPB001452 IPB008266 UniProtKB/Swiss-Prot: ABL2_HUMAN, P42684 Domain : Contains two distinct classes of F-actin-binding domains. Although both can bind F-actin, the 2 are required tobundle actin filaments (By similarity) Similarity : Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamilySimilarity : Contains 1 protein kinase domainSimilarity : Contains 1 SH2 domainSimilarity : Contains 1 SH3 domain
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Functionfor ABL2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: ABL2_HUMAN, P42684 Function : Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cellgrowth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1 Catalytic activity : ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphateEnzyme regulation : Stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linkerregion, interactions of the N-terminal cap, and contributions from an N-terminal myristoyl group and phospholipids. Activated by autophosphorylation as well as by SRC-family kinase-mediated phosphorylation. Activated by RIN1 binding to the SH2 and SH3 domains. Inhibited by imatinib mesylate (Gleevec) which is used for the treatment of chronic myeloid leukemia (CML). Phosphatidylinositol 4,5-bisphosphate (PIP2), a highly abundant phosphoinositide known to regulate cytoskeletal and membrane proteins, inhibits the tyrosine kinase activity (By similarity)
Genatlas biochemistry entry for ABL2 Abelson murine leukemia viral (v-abl) oncogene homolog 2 Enzyme Numbers (IUBMB): EC 2.7.10.2 1 2 EC 2.7.10 2 Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9 ): About this table
About GeneDecksing Phenotypes: 4 GenomeRNAi human phenotypes for ABL2 :9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Abl2) :About GeneDecksing Animal Models: Abl2 tm1Ajk for ABL2Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 12 )human mouse rat see all 10 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 8 ): ABL2 (NM_001136001 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ABL2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ABL2
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABL2
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Pathways & Interactionsfor ABL2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/9 super-pathways (see all 9 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Axon guidance 2 Role of Abl in Robo-Slit signaling 3 Signaling by Slit 4 Guidance Cues and Growth Cone Motility 5 ErbB signaling pathway
Pathway sources See GeneCards unified pathways Show all pathways 4 4 2 (Kegg details for ABL2) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ABL2 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/53 Interacting proteins for ABL2 (P42684 1 , 2 , 3 ENSP00000356595 4 via UniProtKB, MINT, STRING , and/or I2D (see all 53 )Interactant Interaction Details GeneCard External ID(s) ERBB3 P21860 2 , 3 ENSP00000267101 4 MINT-74450 MINT-74445 MINT-74451 MINT-74452 MINT-74453 MINT-74448 MINT-74446 MINT-74447 MINT-74449 MINT-74454 I2D:
score=2 STRING: ENSP00000267101 RIN1 Q13671 1 , 2 , 3 ENSP00000310406 4 EBI-1102694,EBI-366017 MINT-59458 MINT-59459 I2D:
score=3 STRING: ENSP00000310406 FYN P06241 1 , 2 , 3 ENSP00000357656 4 EBI-1102694,EBI-2561531 MINT-8110899 I2D:
score=3 STRING: ENSP00000357656 PIK3R1 P27986 1 , 2 , 3 ENSP00000274335 4 EBI-1102694,EBI-79464 MINT-8111655 I2D:
score=3 STRING: ENSP00000274335 PLCG1 P19174 1 , 2 , 3 ENSP00000244007 4 EBI-1102694,EBI-79387 MINT-8112351 I2D:
score=3 STRING: ENSP00000244007
About this table Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16 ): About this table
About GeneDecksing
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Drugs & Compoundsfor ABL2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for ABL2 4 HMDB Compounds for ABL2 About this table 3 DrugBank Compounds for ABL2 About this table 5 Novoseek chemical compound relationships for ABL2 gene About this table ABL2
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Transcriptsfor ABL2 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ABL2 gene (8 alternative transcripts): NM_001136000.2 NM_001136001.1 NM_001168236.1 NM_001168237.1 NM_001168238.1 NM_001168239.1 NM_005158.4 NM_007314.3 Unigene Cluster for ABL2:
V-abl Abelson murine leukemia viral oncogene homolog 2 Hs.159472 [show with all ESTs ] Unigene Representative Sequence: NM_007314 12 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000502732 (uc010pnf.2 uc010png.2 uc001gmj.4 uc010pnh.2 )ENST00000344730 ENST00000512653 ENST00000504405 ENST00000367623 ENST00000507173 ENST00000511413 ENST00000392043 (uc009wxe.3 ) ENST00000509520 ENST00000504324 (uc001gmk.3 uc009wxf.2 )ENST00000508127 ENST00000408940 (uc001gmg.4 uc001gmi.4 uc010pne.2 )Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 12 )human mouse rat see all 10 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 8 ): ABL2 (NM_001136001 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ABL2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ABL2
Additional cDNA sequence: AK025877.1 AK056280.1 AK225255.1 AK309549.1 AK311045.1 BC065912.1 BX538317.1 FJ542283.1 FJ542284.1 FJ542285.1 FJ542286.1 M35296.1
12 DOTS entries : DT.100754808 DT.100755319
DT.423211 DT.306356 DT.102826726 DT.91661488 DT.121446659 DT.121446570 DT.121446577 DT.95152104 DT.95127239 DT.97818073 24/181 AceView cDNA sequences (see all 181 ):
BC065912 NM_005158 NM_007314 AA371305 BQ672160 BQ227288 BU634226 CD369364 BQ678351 BQ216804 BX475633 F02595 BQ014740 BM466684 BM719893 AW613399 H80903 CA447716 BQ674289 BU169285 F12791 Z43953 BM676754 M35296 GeneLoc Exon Structure
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Expression for ABL2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ABL2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CGGATTCAATAbout this image ABL2 expression in embryonic tissues and stem cells About this table
2 LifeMap In Vivo Development Anatomical Compartments/CellsTissue Category (developmental path) Bone Stylopod Long Bone Bone Bone Zeugopod Long Bone Bone Expression: Experimental details:
In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell Name Category PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
See ABL2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ABL2 SOURCE GeneReport for Unigene cluster: Hs.159472 UniProtKB/Swiss-Prot: ABL2_HUMAN, P42684 Tissue specificity : Widely expressedSABiosciences Custom PCR Arrays for ABL2 Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABL2 In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABL2
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Orthologsfor ABL2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for ABL2 gene from 8/24 species (see all 24 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves ABL21
v-abl Abelson murine leukemia viral oncogene homolog more
81.52(n) 89.92(a)
395410 XM_422269.3 XP_422269.3
lizard Reptilia ABL26
--
84(a)
1 ↔ 1
GL343300.1(844869-866104)
African clawed frog Amphibia AF237766.12
--
75.84(n)
AF237766.1
zebrafish Actinopterygii abl21
v-abl Abelson murine leukemia viral oncogene homolog more
67.8(n) 75.21(a)
570636 NM_001122705.1 NP_001116177.1
fruit fly Insecta Abl3
axon guidance protein tyrosine kinase
72(a)
--
worm Secernentea abl-13
Src homology domain 2, Src homology domainmore
59(a)
X(10641430-10659377) --
thale cress eudicotyledons AT1G162706 6 see all 7 )
octicosapeptide/Phox/Be.1 domain-containing protei... octicosapeptide/Phox/Bem1p domain-containing prote... (see all 7 )9(a) 9(a) (see all 7 )
many ↔ manymany ↔ many(see all 7 )
1(5563087-5568368) 5(23324791-23329347)
rice Liliopsida ----(see all 5 )
protein kinase domain containing protein, expresse... protein kinase domain containing protein, expresse... (see all 5 )9(a) 9(a) (see all 5 )
many ↔ manymany ↔ many(see all 5 )
2(33380337-33387027) 7(14722116-14730584)
ENSEMBL Gene Tree for ABL2 (if available)TreeFam Gene Tree for ABL2 (if available)
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Paralogsfor ABL2 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ABL2 gene FRK 2 LCK 2 BLK 2 ITK 2 LYN 2 YES1 2 TXK 2 HCK 2 ABL1 2 BMX 2 SRMS 2 TEC 2 FGR 2 PTK6 2 SRC 2 FYN 2 BTK 2 17 SIMAP similar genes for ABL2 using alignment to 1 protein entry: ABL2_HUMAN :ABL1 BCR/ABL fusion GRB2 BMX FRK CSK TEC BTK EPHA2 FYN GRAP ITK PTK6 FGR SRMS MATK SH2D1A About GeneDecksing
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Genomic Variantsfor ABL2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 1 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for ABL2 (179068462 - 179198819 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ABL2: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor ABL2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 164690
OMIM disorders : --17 : About MalaCards leukemia non-small cell lung carcinoma leukemia, acute myeloid, with eosinophilia eosinophilia chronic myeloid leukemia myeloproliferative disorder myeloid leukemia lung carcinoma thymoma colorectal cancer gastric adenocarcinoma lung cancer adenocarcinoma carcinoma breast cancer adenoma neuronitis 4 Novoseek disease relationships for ABL2 gene About this table
Human Genome Epidemiology (HuGE) Navigator: ABL2 (6 documents) Tumor Gene Database (TGDB) : ABL2 Export disorders for ABL2 gene to outside databases
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Publicationsfor ABL2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ABL2 gene, integrated from 9 sources (see all 105 ):(articles sorted by number of sources associating them with ABL2) Utopia : connect your pdf to the dynamic
A novel human gene closely related to the abl proto-oncogene. (PubMed id 3787260) 1 , 2 , 3(1986) Eight full-length abelson related gene (Arg) isoforms are constitutively expressed in caki-1 cell line and cell distribution of two isoforms has been analyzed after transfection. (PubMed id 18810762) 1 , 2 , 9(2008) Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation. (PubMed id 16678104) 1 , 2 , 9(2006) Ubiquitination and degradation of the Arg tyrosine kinase is regulated by oxidative stress. (PubMed id 15735735) 1 , 2 , 9(2005) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 1 , 2 (2006) RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration. (PubMed id 15886098) 1 , 2 (2005) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) Two distinct phosphorylation pathways have additive e ffects on Abl family kinase activation. (PubMed id 12748290) 1 , 2 (2003) The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases. (PubMed id 2198571) 1 , 2 (1990)
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External Searches for ABL2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ABL2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing ABL2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ABL2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for ABL2 Pharmacogenomics, SNPs, Pathways ATLAS Chromosomes in Cancer entry for ABL2Genetics and Cytogenetics in Oncology and Haematology NIEHS-SNPs http://egp.gs.washington.edu/data/abl2/ CGP resequencing studies http://www.sanger.ac.uk/perl/genetics/CGP/cgp_viewer?action=gene&ln=ABL2
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About This Section Patent Information for ABL2 gene: ABL2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ABL2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
OriGene Antibodies for ABL2 OriGene shRNA RFP for ABL2 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for ABL2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ABL2 OriGene 3'-UTR Clone for ABL2 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for ABL2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ABL2 OriGene Custom Protein Services for ABL2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ABL2 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABL2 QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Search Tocris compounds for ABL2
ABL2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABL2
ThermoFisher Antibodies for ABL2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ABL2
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and Proteopedia 
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Expression by the Database of Embryonic development, Stem cell research, and
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Negative
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