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Aliases for ABI3BP Gene

Aliases for ABI3BP Gene

  • ABI Family Member 3 Binding Protein 2 3 5
  • ABI Family, Member 3 (NESH) Binding Protein 2 3
  • ABI Gene Family Member 3-Binding Protein 3 4
  • Nesh-Binding Protein 3 4
  • Target Of Nesh-SH3 2 3
  • NESHBP 3 4
  • TARSH 3 4
  • ABI Gene Family, Member 3 (NESH) Binding Protein 3

External Ids for ABI3BP Gene

Previous GeneCards Identifiers for ABI3BP Gene

  • GC03M101951
  • GC03M100468
  • GC03M097836

Summaries for ABI3BP Gene

GeneCards Summary for ABI3BP Gene

ABI3BP (ABI Family Member 3 Binding Protein) is a Protein Coding gene. GO annotations related to this gene include heparin binding and glycosaminoglycan binding. An important paralog of this gene is FNDC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABI3BP Gene

Genomics for ABI3BP Gene

Regulatory Elements for ABI3BP Gene

Enhancers for ABI3BP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F100968 1.2 ENCODE 16.7 +22.8 22769 3.7 OSR2 GLIS1 CEBPB WT1 ABI3BP ZBTB11 RNU6-865P
GH03F100965 0.2 ENCODE 11 +27.3 27293 2.3 JUND RAD21 ABI3BP RNU6-865P
GH03F100929 0.2 ENCODE 10.9 +64.3 64304 0.2 RNU6-865P ABI3BP GC03M100931 LOC100421580
GH03F101034 0.8 Ensembl ENCODE 6.9 -42.6 -42559 2.8 CTCF ZNF146 JUN TEAD4 CEBPB RAD21 EP300 RFX5 JUND SMC3 ABI3BP GC03M101028 GC03P101038
GH03F100991 0.2 ENCODE 6.1 +0.7 713 2.8 CTCF CREB3L1 JUN SIN3A ZNF384 RAD21 ZNF335 ZNF316 ZFHX2 POLR2A ABI3BP PDCL3P4 NXPE3 RNU6-865P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ABI3BP on UCSC Golden Path with GeneCards custom track

Promoters for ABI3BP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001369496 1014 2599 CTCF CREB3L1 JUN SIN3A ZNF384 RAD21 ZNF316 ZFHX2 POLR2A SCRT2

Genomic Location for ABI3BP Gene

Chromosome:
3
Start:
100,749,156 bp from pter
End:
100,993,515 bp from pter
Size:
244,360 bases
Orientation:
Minus strand

Genomic View for ABI3BP Gene

Genes around ABI3BP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABI3BP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABI3BP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABI3BP Gene

Proteins for ABI3BP Gene

  • Protein details for ABI3BP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7G0-TARSH_HUMAN
    Recommended name:
    Target of Nesh-SH3
    Protein Accession:
    Q7Z7G0
    Secondary Accessions:
    • B3KSL4
    • Q6ZW20
    • Q6ZW22
    • Q9C082
    • Q9UFI6

    Protein attributes for ABI3BP Gene

    Size:
    1075 amino acids
    Molecular mass:
    118642 Da
    Quaternary structure:
    • Probably interacts with ABI3.
    SequenceCaution:
    • Sequence=CAB56034.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ABI3BP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABI3BP Gene

Post-translational modifications for ABI3BP Gene

  • Glycosylation at Asn 44
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ABI3BP Gene

Domains & Families for ABI3BP Gene

Gene Families for ABI3BP Gene

Protein Domains for ABI3BP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ABI3BP Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z7G0

UniProtKB/Swiss-Prot:

TARSH_HUMAN :
  • Contains 2 fibronectin type-III domains.
Domain:
  • Contains 2 fibronectin type-III domains.
genes like me logo Genes that share domains with ABI3BP: view

Function for ABI3BP Gene

Gene Ontology (GO) - Molecular Function for ABI3BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005518 collagen binding IEA --
GO:0005539 glycosaminoglycan binding IEA --
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with ABI3BP: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ABI3BP

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ABI3BP Gene

Localization for ABI3BP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABI3BP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABI3BP Gene COMPARTMENTS Subcellular localization image for ABI3BP gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 2
cytosol 2
nucleus 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ABI3BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005614 interstitial matrix IEA --
GO:0005615 extracellular space IDA 20551380
GO:0031012 colocalizes_with extracellular matrix IDA 20551380
genes like me logo Genes that share ontologies with ABI3BP: view

Pathways & Interactions for ABI3BP Gene

SuperPathways for ABI3BP Gene

No Data Available

Gene Ontology (GO) - Biological Process for ABI3BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010811 positive regulation of cell-substrate adhesion IEA --
GO:0030198 extracellular matrix organization IEA --
genes like me logo Genes that share ontologies with ABI3BP: view

No data available for Pathways by source and SIGNOR curated interactions for ABI3BP Gene

Transcripts for ABI3BP Gene

Unigene Clusters for ABI3BP Gene

ABI family, member 3 (NESH) binding protein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABI3BP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: - -
SP2: -
SP3:
SP4:
SP5:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36 ^ 37a · 37b
SP1: -
SP2:
SP3:
SP4:
SP5:

Relevant External Links for ABI3BP Gene

GeneLoc Exon Structure for
ABI3BP
ECgene alternative splicing isoforms for
ABI3BP

Expression for ABI3BP Gene

mRNA expression in normal human tissues for ABI3BP Gene

mRNA differential expression in normal tissues according to GTEx for ABI3BP Gene

This gene is overexpressed in Artery - Tibial (x4.2).

Protein differential expression in normal tissues from HIPED for ABI3BP Gene

This gene is overexpressed in Serum (21.9), Vitreous humor (11.9), and Skin (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ABI3BP Gene



Protein tissue co-expression partners for ABI3BP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ABI3BP Gene:

ABI3BP

SOURCE GeneReport for Unigene cluster for ABI3BP Gene:

Hs.477015

mRNA Expression by UniProt/SwissProt for ABI3BP Gene:

Q7Z7G0-TARSH_HUMAN
Tissue specificity: Expressed in brain, heart, lung, liver, pancreas kidney and placenta.
genes like me logo Genes that share expression patterns with ABI3BP: view

Primer Products

Orthologs for ABI3BP Gene

This gene was present in the common ancestor of chordates.

Orthologs for ABI3BP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABI3BP 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ABI3BP 34 35
  • 87.53 (n)
dog
(Canis familiaris)
Mammalia ABI3BP 35
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abi3bp 35
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABI3BP 35
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABI3BP 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves ABI3BP 34 35
  • 63.37 (n)
lizard
(Anolis carolinensis)
Reptilia ABI3BP 35
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii abi3bp 35
  • 43 (a)
OneToMany
ABI3BP (1 of 2) 35
  • 32 (a)
OneToMany
-- 34
Species where no ortholog for ABI3BP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABI3BP Gene

ENSEMBL:
Gene Tree for ABI3BP (if available)
TreeFam:
Gene Tree for ABI3BP (if available)

Paralogs for ABI3BP Gene

Variants for ABI3BP Gene

Sequence variations from dbSNP and Humsavar for ABI3BP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10049238 -- 100,972,254(+) AATCA(A/C)ATTTT intron-variant
rs1017438 -- 100,880,715(+) GCAGA(C/T)GCTGC intron-variant
rs1017439 -- 100,880,783(+) TGATA(A/G)TATAT intron-variant
rs1027703 -- 100,751,238(-) CTTGC(A/G)TTATT intron-variant
rs1027704 -- 100,749,586(-) GAATG(A/T)ATCAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ABI3BP Gene

Variant ID Type Subtype PubMed ID
dgv182e55 CNV gain 17911159
dgv183e55 CNV gain 17911159
dgv819n67 CNV loss 20364138
dgv8480n54 CNV loss 21841781
dgv8481n54 CNV loss 21841781
esv21526 CNV loss 19812545
esv2308387 CNV deletion 18987734
esv2422136 CNV deletion 20811451
esv2534604 CNV deletion 19546169
esv2659333 CNV deletion 23128226
esv2668933 CNV deletion 23128226
esv2725700 CNV deletion 23290073
esv2759163 CNV loss 17122850
esv28693 CNV loss 19812545
esv3393889 CNV insertion 20981092
esv3562288 CNV deletion 23714750
esv3597180 CNV loss 21293372
esv3597183 CNV loss 21293372
esv5408 CNV loss 18987735
nsv10294 CNV loss 18304495
nsv3922 CNV deletion 18451855
nsv441834 CNV loss 18776908
nsv514163 CNV loss 21397061
nsv525082 CNV loss 19592680
nsv822202 CNV loss 20364138
nsv954333 CNV deletion 24416366

Variation tolerance for ABI3BP Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.16; 95.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABI3BP Gene

Human Gene Mutation Database (HGMD)
ABI3BP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABI3BP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABI3BP Gene

Disorders for ABI3BP Gene

Relevant External Links for ABI3BP

Genetic Association Database (GAD)
ABI3BP
Human Genome Epidemiology (HuGE) Navigator
ABI3BP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABI3BP

No disorders were found for ABI3BP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABI3BP Gene

Publications for ABI3BP Gene

  1. Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3. (PMID: 11501947) Matsuda S. … Hamaguchi M. (J. Hum. Genet. 2001) 2 3 4 64
  2. Genome-wide association study of suicide attempts in mood disorder patients. (PMID: 21041247) Perlis R.H. … Smoller J.W. (Am J Psychiatry 2010) 3 46 64
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
  4. Cancer-associated loss of TARSH gene expression in human primary lung cancer. (PMID: 16205947) Terauchi K. … Fushiki S. (J. Cancer Res. Clin. Oncol. 2006) 3 22 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for ABI3BP Gene

Sources for ABI3BP Gene

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