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Aliases for ABI3BP Gene

Aliases for ABI3BP Gene

  • ABI Family Member 3 Binding Protein 2 3 5
  • ABI Family, Member 3 (NESH) Binding Protein 2 3
  • ABI Gene Family Member 3-Binding Protein 3 4
  • Nesh-Binding Protein 3 4
  • Target Of Nesh-SH3 2 3
  • NESHBP 3 4
  • TARSH 3 4
  • ABI Gene Family, Member 3 (NESH) Binding Protein 3

External Ids for ABI3BP Gene

Previous GeneCards Identifiers for ABI3BP Gene

  • GC03M101951
  • GC03M100468
  • GC03M097836

Summaries for ABI3BP Gene

GeneCards Summary for ABI3BP Gene

ABI3BP (ABI Family Member 3 Binding Protein) is a Protein Coding gene. GO annotations related to this gene include heparin binding and glycosaminoglycan binding. An important paralog of this gene is FNDC1.

Additional gene information for ABI3BP Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABI3BP Gene

Genomics for ABI3BP Gene

Regulatory Elements for ABI3BP Gene

Enhancers for ABI3BP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H100968 0.8 ENCODE dbSUPER 16.8 +22.8 22769 3.7 OSR2 PRDM6 GLIS1 CEBPB WT1 ABI3BP ZBTB11 RNU6-865P
GH03H100965 0.8 ENCODE dbSUPER 11 +27.3 27293 2.3 JUND POLR2A CREB1 RCOR1 ABI3BP RNU6-865P
GH03H100898 1.2 Ensembl ENCODE dbSUPER 5.8 +93.5 93494 2.8 JUN BATF GATA3 ZNF316 NFE2 MAFK SMARCE1 JUNB CEBPB MAFG RNU6-865P PDCL3P4 ABI3BP GC03M100889 GC03P100905
GH03H101034 0.9 Ensembl ENCODE 6.9 -42.6 -42559 2.8 ZNF146 JUN CEBPB EP300 RFX5 JUND GATA3 POLR2A STAT3 RCOR1 ABI3BP GC03M101028 GC03P101038
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ABI3BP on UCSC Golden Path with GeneCards custom track

Promoters for ABI3BP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000155707 814 1800 JUN ZSCAN4 ZNF384 RAD21 ZFHX2 POLR2A SCRT2 PRDM10 MAFK EGR2

Genomic Locations for ABI3BP Gene

Genomic Locations for ABI3BP Gene
244,360 bases
Minus strand

Genomic View for ABI3BP Gene

Genes around ABI3BP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABI3BP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABI3BP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABI3BP Gene

Proteins for ABI3BP Gene

  • Protein details for ABI3BP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Target of Nesh-SH3
    Protein Accession:
    Secondary Accessions:
    • B3KSL4
    • Q6ZW20
    • Q6ZW22
    • Q9C082
    • Q9UFI6

    Protein attributes for ABI3BP Gene

    1075 amino acids
    Molecular mass:
    118642 Da
    Quaternary structure:
    • Probably interacts with ABI3.
    • Sequence=CAB56034.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ABI3BP Gene


neXtProt entry for ABI3BP Gene

Post-translational modifications for ABI3BP Gene

  • Glycosylation at Asn44
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ABI3BP Gene

Domains & Families for ABI3BP Gene

Gene Families for ABI3BP Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ABI3BP Gene


Suggested Antigen Peptide Sequences for ABI3BP Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ABI3BP: view

No data available for UniProtKB/Swiss-Prot for ABI3BP Gene

Function for ABI3BP Gene

Phenotypes From GWAS Catalog for ABI3BP Gene

Gene Ontology (GO) - Molecular Function for ABI3BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005518 collagen binding IEA --
GO:0005539 glycosaminoglycan binding IEA --
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with ABI3BP: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ABI3BP Gene

Localization for ABI3BP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABI3BP Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABI3BP gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 2
nucleus 2
cytosol 2
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (1)
  • Cytosol (1)
  • Nuclear speckles (1)
  • Nucleoli (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ABI3BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005614 interstitial matrix IEA --
GO:0005615 extracellular space IDA 20551380
GO:0031012 colocalizes_with extracellular matrix IDA 20551380
genes like me logo Genes that share ontologies with ABI3BP: view

Pathways & Interactions for ABI3BP Gene

SuperPathways for ABI3BP Gene

No Data Available

Interacting Proteins for ABI3BP Gene

Gene Ontology (GO) - Biological Process for ABI3BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010811 positive regulation of cell-substrate adhesion IEA --
GO:0030198 extracellular matrix organization IEA --
genes like me logo Genes that share ontologies with ABI3BP: view

No data available for Pathways by source and SIGNOR curated interactions for ABI3BP Gene

Drugs & Compounds for ABI3BP Gene

No Compound Related Data Available

Transcripts for ABI3BP Gene

Unigene Clusters for ABI3BP Gene

ABI family, member 3 (NESH) binding protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABI3BP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: - -
SP2: -

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36 ^ 37a · 37b
SP1: -

Relevant External Links for ABI3BP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ABI3BP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ABI3BP Gene

mRNA differential expression in normal tissues according to GTEx for ABI3BP Gene

This gene is overexpressed in Artery - Tibial (x4.2).

Protein differential expression in normal tissues from HIPED for ABI3BP Gene

This gene is overexpressed in Serum (21.9), Vitreous humor (11.9), and Skin (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ABI3BP Gene

Protein tissue co-expression partners for ABI3BP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ABI3BP Gene:


SOURCE GeneReport for Unigene cluster for ABI3BP Gene:


mRNA Expression by UniProt/SwissProt for ABI3BP Gene:

Tissue specificity: Expressed in brain, heart, lung, liver, pancreas kidney and placenta.

Evidence on tissue expression from TISSUES for ABI3BP Gene

  • Lung(4.5)
  • Liver(4.1)
  • Thyroid gland(2.5)
genes like me logo Genes that share expression patterns with ABI3BP: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ABI3BP Gene

Orthologs for ABI3BP Gene

This gene was present in the common ancestor of chordates.

Orthologs for ABI3BP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ABI3BP 34
  • 98 (a)
(Bos Taurus)
Mammalia ABI3BP 33 34
  • 87.53 (n)
(Canis familiaris)
Mammalia ABI3BP 34
  • 76 (a)
(Mus musculus)
Mammalia Abi3bp 34
  • 68 (a)
(Monodelphis domestica)
Mammalia ABI3BP 34
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia ABI3BP 34
  • 57 (a)
(Gallus gallus)
Aves ABI3BP 33 34
  • 63.37 (n)
(Anolis carolinensis)
Reptilia ABI3BP 34
  • 52 (a)
(Danio rerio)
Actinopterygii abi3bp 34
  • 43 (a)
ABI3BP (1 of 2) 34
  • 32 (a)
-- 33
Species where no ortholog for ABI3BP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABI3BP Gene

Gene Tree for ABI3BP (if available)
Gene Tree for ABI3BP (if available)

Paralogs for ABI3BP Gene

Variants for ABI3BP Gene

Sequence variations from dbSNP and Humsavar for ABI3BP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000001664 -- 100,881,765(+) AGAAT(-/CA)CAGTT intron-variant
rs1000018951 -- 100,841,622(+) AGTGG(C/T)TCACA intron-variant
rs1000038255 -- 100,888,529(+) TCAAG(G/T)CTTTG intron-variant
rs1000048953 -- 100,771,395(+) TAATT(A/T)AAAAA intron-variant
rs1000073738 -- 100,935,122(+) TGTTT(A/C)AGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABI3BP Gene

Variant ID Type Subtype PubMed ID
nsv954333 CNV deletion 24416366
nsv822202 CNV loss 20364138
nsv525082 CNV loss 19592680
nsv514163 CNV loss 21397061
nsv441834 CNV loss 18776908
nsv3922 CNV deletion 18451855
nsv10294 CNV loss 18304495
esv5408 CNV loss 18987735
esv3597183 CNV loss 21293372
esv3597180 CNV loss 21293372
esv3562288 CNV deletion 23714750
esv3393889 CNV insertion 20981092
esv28693 CNV loss 19812545
esv2759163 CNV loss 17122850
esv2725700 CNV deletion 23290073
esv2668933 CNV deletion 23128226
esv2659333 CNV deletion 23128226
esv2534604 CNV deletion 19546169
esv2422136 CNV deletion 20811451
esv2308387 CNV deletion 18987734
esv21526 CNV loss 19812545
dgv8481n54 CNV loss 21841781
dgv8480n54 CNV loss 21841781
dgv819n67 CNV loss 20364138
dgv183e55 CNV gain 17911159
dgv182e55 CNV gain 17911159

Variation tolerance for ABI3BP Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.16; 95.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABI3BP Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABI3BP Gene

Disorders for ABI3BP Gene

Relevant External Links for ABI3BP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ABI3BP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABI3BP Gene

Publications for ABI3BP Gene

  1. Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3. (PMID: 11501947) Matsuda S … Hamaguchi M (Journal of human genetics 2001) 2 3 4 60
  2. Genome-wide association study of suicide attempts in mood disorder patients. (PMID: 21041247) Perlis RH … Smoller JW (The American journal of psychiatry 2010) 3 45 60
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 45 60
  4. Cancer-associated loss of TARSH gene expression in human primary lung cancer. (PMID: 16205947) Terauchi K … Fushiki S (Journal of cancer research and clinical oncology 2006) 3 22 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for ABI3BP Gene

Sources for ABI3BP Gene

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