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ABI3BP Gene

protein-coding   GIFtS: 50

GC03M101951
ABI family, member 3 (NESH) binding protein
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
DKFZP586L2024 1
FLJ41743 2
FLJ41754 2
NESHBP 1, 2, 3
NeshBP 3
TARSH 1, 2, 3
Tarsh 3
Descriptions
ABI family, member 3 (NESH) binding protein 2
ABI family, member 3 binding protein 1
ABI gene family member 3-binding protein 3
ABI gene family, member 3 (NESH) binding protein 2
Nesh-binding protein 3
target of Nesh-SH3 2
External Ids
HGNC: 172651
Entrez Gene: 258902
UniProtKB: Q7Z7G03
Ensembl: ENSG000001541757
Search outside databases for aliases for ABI3BP gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ABI3BP gene  

Entrez Gene cytogenetic band: 3q12   Ensembl cytogenetic band:  3q12.2   HGNC cytogenetic band: 3q12

ABI3BP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M101951:     (about GC identifiers)

Start:
101,950,869 bp from pter
End:
102,195,004 bp from pter
Size:
244,136 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000003.10  NT_005612.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TARSH_HUMAN, Q7Z7G0 (See protein sequence)
Recommended Name: Target of Nesh-SH3 precursor  
Size: 1075 amino acids; 118642 Da
Subunit: Probably interacts with ABI3
Secondary accessions: Q6ZW20 Q6ZW22 Q9C082 Q9UFI6
Alternative splicing: 4 isoforms:  Q7Z7G0-1   Q7Z7G0-2   Q7Z7G0-3   Q7Z7G0-4   

REFSEQ proteins: NP_056244.2  

ENSEMBL proteins: 
ENSP00000381332 ENSP00000284322 ENSP00000373189 ENSP00000273339 ENSP00000373190 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (ABI3BP)
Human Recombinant Proteins from Abnova (ABI3BP)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for ABI3BP: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Antibodies from Abcam (ABI3BP), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (ABI3BP)
Novus Biologicals Antibodies for ABI3BP

Assays for ABI3BP: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro domains/families:
 IPR008957 Fibronectin_typ-III-like_fold
 IPR003961 FN_III


   GeneDecks  ABI3BP for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q7Z7G0

ProtoNet protein and cluster: Q7Z7G0

UniProtKB/Swiss-Prot: TARSH_HUMAN, Q7Z7G0
Similarity: Contains 2 fibronectin type-III domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (ABI3BP)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015429

              Applied Biosystems Silencer® siRNAs for ABI3BP

              Sigma-Aldrich siRNA for ABI3BP  
                     Sigma-Aldrich shRNA for ABI3BP  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for ABI3BP
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015429
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_015429
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_015429 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_015429

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section



2 Interacting proteins for ABI3BP (ENSP000002843223) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
ABI3ENSP000002259413STRING (score=.982)
ABI1ENSP000003475553STRING (score=.712)
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ABI3BP

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (ABI3BP)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015429

              Sigma-Aldrich siRNA for ABI3BP  
                     Sigma-Aldrich shRNA for ABI3BP  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_015429  

REFSEQ mRNAs for ABI3BP gene: 

NM_015429.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_015429  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015429
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_015429
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_015429 

Additional cDNA sequence: 

AB056106.1 AK025204.1 AK093861.1 AK123737.1 AK123748.1 AK299938.1 AL117664.1 AL162038.1 
AL833204.1 BC030221.1 BX648726.1 

21 DOTS entries:

DT.313065  DT.97791341  DT.100787624  DT.97788516  DT.99985081  DT.100678469  DT.101981876  DT.306802 
DT.95313476  DT.100787626  DT.120847676  DT.120847770  DT.120847631  DT.100001413  DT.120847650  DT.100736619 
DT.120847692  DT.120847775  DT.40270440  DT.95306976  DT.97785684 

24/174 AceView cDNA sequences (see all 174 ):

CD674022 AL598441 AI378667 AA328200 BE501280 BX385808 BG741740 AW471460 
BX284017 CA390839 AB056106 AK123748 CD674023 AA345718 AK025204 AA256582 
AI123952 AA304549 AA009827 BM888508 D45547 BP335920 AU280309 W81545 

highest scoring ESTs for ABI3BP:

AA742544 AA009827 AK025204 AL597809 AL701288 AL706230 AL706242 AL709454 AL709618 AL833204 

Unigene Cluster for ABI3BP:

ABI family, member 3 (NESH) binding protein
Hs.477015  [show with all ESTs]
Unigene Representative Sequence: BX648726


GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ABI3BP

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1:        -                                                                                                           -                                       
SP2:                                                                                                                                            -               
SP3:                                                                                                                                                            
SP4:                                                                                                                                                            
SP5:                                                                                                                                                            

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36 ^ 37a · 37b
SP1:        -                                                                                 
SP2:                                                                                          
SP3:                                                                                          
SP4:                                                                                          
SP5:                                                                                          

About this scheme

ECgene alternative splicing isoforms for ABI3BP

5 Ensembl transcripts including schematic representations:
ENST00000398284  ENST00000284322  ENST00000383691  ENST00000273339  ENST00000383692  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ABI3BP expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for ABI3BP

1 / 2 / 3

7 probe-sets matching ABI3BP gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

83899_at2, 3 U95-E 1 1.00 1.00 0.84 0.95 AA742544 1.00 1.00 1.00 1
44813_s_at2, 3 U95-B 1 1.00 1.00 0.92 1.24 W78050 0.80 1.00 0.91 1
64464_r_at2, 3 U95-C 1 0.31 1.00 0.93 0.81 AW022777 0.80 1.00 0.91 1

223395_at2, 3 U133-B 1 1.00 1.00 -- -- AB056106 0.60 1.00 0.82 1

220518_at2, 3 U133-A 1 1.00 1.00 -- -- NM_024801 0.20 1.00 0.72 1

223395_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

220518_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  ABI3BP for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CTTCAATCTT

SOURCE GeneReport for Unigene cluster: Hs.477015

UniProtKB/Swiss-Prot: TARSH_HUMAN, Q7Z7G0
Tissue specificity: Expressed in brain, heart, lung, liver, pancreas kidney and placenta

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for ABI3BP gene from 4 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
ABI3BP1   -- ABI family, member 3 (NESH) binding protein 84.4(n)
82.78(a)
478544  XM_535721.2  XP_535721.2 
cow
(Bos taurus)
ABI3BP1   -- ABI family, member 3 (NESH) binding protein 88.92(n)
87.97(a)
538604  XM_581418.3  XP_581418.3 
mouse
(Mus musculus)
Abi3bp1, 5 165
ABI gene family, member 3 (NESH) binding protein1, 5 84.06(n)1
82.05(a)1
3207121  NM_001014422.11  NP_001014422.11 
 AB1903395  AB1903405  (see all 19)
zebrafish
(Danio rerio)
BC045333.12   --   -- 72.85(n) 334109  BC045333.1 
About this table        Species with no ortholog for ABI3BP

ENSEMBL Gene Tree for ABI3BP
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for ABI3BP gene
FNDC12  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/1407 NCBI SNPs in ABI3BP are shown (see all 1407 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 519)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 3 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs98137301,2
A,C,F,H101951965(+) GAATGC/TGGCAT 1 -- ut31 ese37Minor allele frequency- T:0.04EU EA WA NA 560
rs38066551,2
A,C,F,H102196626(-) AGGGAA/GCTGCT 1 -- ng31 tfbs39Minor allele frequency- N:0.00EA NA EU WA 1932
rs10483641,2
C,F,H101951190(-) TGCACG/AATGAG 1 -- ut31 ese317Minor allele frequency- A:0.30MN NA EA EU WA 1654
rs168431281,2
C,F,H102196104(+) ACACAC/TAGGAA 1 -- ng3111Minor allele frequency- T:0.08NA EU EA WA 972
--
rs109364591,2
A,F,H102196379(+) AGTAAG/CAGAAA 1 -- ng31 tfbs3 trp33Minor allele frequency- C:0.25EA WA 250
rs37328951,2
C,F,H102194939(-) TCCCCA/GTGCGA 1 V mis116Minor allele frequency- N:0.00NA MN EA EU WA 2488
rs14493051,2
C,F,H102195817(-) TAACAC/TGGAGC 1 -- ng318Minor allele frequency- T:0.23EU EA WA 836
rs117068591,2
C,F,H102195781(+) CTCTAT/CATTAT 1 -- ng314Minor allele frequency- C:0.01EU EA WA 384
rs10277051,2
A,C101951023(-) TTAGGC/TGGGGA 1 -- ut314Minor allele frequency- T:0.00MN NA 326
rs124976751,2
C102195454(+) AGAGTA/GAGTCT 1 -- ng310--------
About this table

HapMap Linkage Disequilibrium images for ABI3BP (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 606279

Human Genome Epidemiology Navigator: ABI3BP (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/13 PubMed articles for ABI3BP gene (see all 13 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 25890 HGNC: 17265 AceView: TARSH Ensembl:ENSG00000154175 euGenes: HUgn25890
ECgene: ABI3BP H-InvDB: ABI3BP
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for ABI3BP:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ABI3BP-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for ABI3BP Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for ABI3BP Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Search OriGene for ABI3BP
 Search Tocris compounds for ABI3BP




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for ABI3BP

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