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Aliases for ABI3 Gene

Aliases for ABI3 Gene

  • ABI Family Member 3 2 3 5
  • New Molecule Including SH3 3 4
  • NESH 3 4
  • ABI Gene Family Member 3 3
  • ABI Family, Member 3 2
  • SSH3BP3 3

External Ids for ABI3 Gene

Previous GeneCards Identifiers for ABI3 Gene

  • GC17P047763
  • GC17P044642
  • GC17P047287
  • GC17P042653

Summaries for ABI3 Gene

Entrez Gene Summary for ABI3 Gene

  • This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for ABI3 Gene

ABI3 (ABI Family Member 3) is a Protein Coding gene. An important paralog of this gene is ABI1.

UniProtKB/Swiss-Prot for ABI3 Gene

  • May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.

Gene Wiki entry for ABI3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABI3 Gene

Genomics for ABI3 Gene

Regulatory Elements for ABI3 Gene

Enhancers for ABI3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F049208 1.2 FANTOM5 ENCODE 13.8 +4.3 4329 12.1 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 SIN3A YBX1 YY1 ZNF766 ZNF143 ABI3 B4GALNT2 GNGT2 CALCOCO2 UBE2Z PIR31803
GH17F049235 0.5 FANTOM5 Ensembl 11.7 +26.0 26008 1.9 BCOR CTCF ZNF316 PKNOX1 IKZF1 ZBTB33 MAFK PHOSPHO1 GNGT2 ABI3 ENSG00000238804 RNU1-42P ENSG00000230532 SNF8 LOC105371811 HOXB13 ZNF652
GH17F049251 0.9 Ensembl ENCODE 11 +42.1 42083 1.9 HDAC1 PKNOX1 NFXL1 GATA2 FOS ZNF263 CEBPB ZEB2 SMARCA4 PBX2 PHOSPHO1 ABI3 GNGT2 ZNF652 FLJ40194 GC17P049267
GH17F049249 0.9 Ensembl ENCODE 11 +39.4 39408 1.1 BCOR KLF1 ESRRA PKNOX1 TAL1 MAX ZMYM3 ZIC2 ZNF121 ZNF366 GNGT2 ABI3 PHOSPHO1 FLJ40194 GC17P049267
GH17F049387 1.4 FANTOM5 Ensembl ENCODE 10.9 +179.6 179574 5.2 PKNOX1 ATF1 ZNF133 FEZF1 DMAP1 GTF3C2 GATA2 FOS KAT8 HMBOX1 ZNF652 ENSG00000262837 LOC102724596 ENSG00000207127 PHB FLJ45513 ABI3 SNF8 PHOSPHO1 GNGT2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ABI3 on UCSC Golden Path with GeneCards custom track

Promoters for ABI3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001348398 573 1601 HDGF ATF1 PKNOX1 ARNT CREB3L1 SIN3A YBX1 ZNF766 ELK1 FOS

Genomic Location for ABI3 Gene

Chromosome:
17
Start:
49,210,227 bp from pter
End:
49,223,225 bp from pter
Size:
12,999 bases
Orientation:
Plus strand

Genomic View for ABI3 Gene

Genes around ABI3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABI3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABI3 Gene

Proteins for ABI3 Gene

  • Protein details for ABI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2A4-ABI3_HUMAN
    Recommended name:
    ABI gene family member 3
    Protein Accession:
    Q9P2A4
    Secondary Accessions:
    • C9IZN8
    • Q9H0P6

    Protein attributes for ABI3 Gene

    Size:
    366 amino acids
    Molecular mass:
    39035 Da
    Quaternary structure:
    • May interact with PAK1 and PAK2. Probably interacts with TARSH.

    Alternative splice isoforms for ABI3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABI3 Gene

Post-translational modifications for ABI3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ABI3 Gene

Domains & Families for ABI3 Gene

Protein Domains for ABI3 Gene

Suggested Antigen Peptide Sequences for ABI3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P2A4

UniProtKB/Swiss-Prot:

ABI3_HUMAN :
  • Contains 1 SH3 domain.
  • Belongs to the ABI family.
Domain:
  • Contains 1 SH3 domain.
Family:
  • Belongs to the ABI family.
genes like me logo Genes that share domains with ABI3: view

No data available for Gene Families for ABI3 Gene

Function for ABI3 Gene

Molecular function for ABI3 Gene

UniProtKB/Swiss-Prot Function:
May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.

Gene Ontology (GO) - Molecular Function for ABI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with ABI3: view
genes like me logo Genes that share phenotypes with ABI3: view

Animal Model Products

miRNA for ABI3 Gene

miRTarBase miRNAs that target ABI3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABI3 Gene

Localization for ABI3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABI3 Gene

Cytoplasm. Note=Colocalizes with PAK2 at leading edge of cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABI3 Gene COMPARTMENTS Subcellular localization image for ABI3 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ABI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 17101133
GO:0005737 cytoplasm NAS,IDA 11956071
GO:0016020 membrane IDA 19946888
GO:0030027 lamellipodium IDA 17101133
genes like me logo Genes that share ontologies with ABI3: view

Pathways & Interactions for ABI3 Gene

SuperPathways for ABI3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ABI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component NAS 11956071
GO:0018108 NOT peptidyl-tyrosine phosphorylation IDA 17101133
GO:0030334 regulation of cell migration IDA 11956071
genes like me logo Genes that share ontologies with ABI3: view

No data available for Pathways by source and SIGNOR curated interactions for ABI3 Gene

Drugs & Compounds for ABI3 Gene

(1) Additional Compounds for ABI3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ABI3: view

Transcripts for ABI3 Gene

Unigene Clusters for ABI3 Gene

ABI family, member 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABI3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8
SP1: - -
SP2: -
SP3:

Relevant External Links for ABI3 Gene

GeneLoc Exon Structure for
ABI3
ECgene alternative splicing isoforms for
ABI3

Expression for ABI3 Gene

mRNA expression in normal human tissues for ABI3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABI3 Gene

This gene is overexpressed in Whole Blood (x10.1) and Spleen (x8.3).

Protein differential expression in normal tissues from HIPED for ABI3 Gene

This gene is overexpressed in Lymph node (14.2), NK cells (13.8), Spleen (10.4), and CD8 Tcells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABI3 Gene



Protein tissue co-expression partners for ABI3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ABI3 Gene:

ABI3

SOURCE GeneReport for Unigene cluster for ABI3 Gene:

Hs.130719

mRNA Expression by UniProt/SwissProt for ABI3 Gene:

Q9P2A4-ABI3_HUMAN
Tissue specificity: Expressed in heart, lung, liver, pancreas, kidney, placenta and at low levels in brain and skeletal muscle.
genes like me logo Genes that share expression patterns with ABI3: view

Primer Products

Orthologs for ABI3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ABI3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABI3 34 35
  • 99.18 (n)
cow
(Bos Taurus)
Mammalia ABI3 34 35
  • 87.08 (n)
dog
(Canis familiaris)
Mammalia ABI3 34 35
  • 86.9 (n)
mouse
(Mus musculus)
Mammalia Abi3 34 16 35
  • 80.85 (n)
rat
(Rattus norvegicus)
Mammalia Abi3 34
  • 80.85 (n)
oppossum
(Monodelphis domestica)
Mammalia ABI3 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABI3 35
  • 32 (a)
OneToOne
chicken
(Gallus gallus)
Aves ABI3 35
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 61 (a)
OneToMany
-- 35
  • 47 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ABI3 (1 of 2) 35
  • 34 (a)
OneToMany
ABI3 (2 of 2) 35
  • 26 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Abi 35
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea abi-1 35
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
OneToMany
Species where no ortholog for ABI3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ABI3 Gene

ENSEMBL:
Gene Tree for ABI3 (if available)
TreeFam:
Gene Tree for ABI3 (if available)

Paralogs for ABI3 Gene

Paralogs for ABI3 Gene

(6) SIMAP similar genes for ABI3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ABI3: view

Variants for ABI3 Gene

Sequence variations from dbSNP and Humsavar for ABI3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1009571 -- 49,212,668(+) agctg(A/G)ggttt intron-variant
rs1009572 -- 49,212,709(+) cctag(C/T)tagtg intron-variant
rs111290838 -- 49,212,713(+) GCTAG(C/T)GTCAG intron-variant
rs111332727 -- 49,221,192(+) AAGGC(C/T)GGGTG intron-variant
rs111336880 -- 49,214,570(+) CTGGG(C/T)GTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABI3 Gene

Variant ID Type Subtype PubMed ID
nsv2074 CNV insertion 18451855
nsv953924 CNV deletion 24416366

Variation tolerance for ABI3 Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.51; 77.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABI3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABI3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABI3 Gene

Disorders for ABI3 Gene

Relevant External Links for ABI3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABI3

No disorders were found for ABI3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABI3 Gene

Publications for ABI3 Gene

  1. Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells. (PMID: 11956071) Ichigotani Y. … Matsuda S. (Cancer Res. 2002) 2 3 4 64
  2. Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein. (PMID: 10978530) Miyazaki K. … Hamaguchi M. (Biochim. Biophys. Acta 2000) 2 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  5. Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3. (PMID: 11501947) Matsuda S. … Hamaguchi M. (J. Hum. Genet. 2001) 3 4 64

Products for ABI3 Gene

Sources for ABI3 Gene

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