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Aliases for ABI3 Gene

Aliases for ABI3 Gene

  • ABI Family Member 3 2 3 5
  • New Molecule Including SH3 3 4
  • ABI Family, Member 3 2 3
  • NESH 3 4
  • SSH3BP3 3

External Ids for ABI3 Gene

Previous GeneCards Identifiers for ABI3 Gene

  • GC17P047763
  • GC17P044642
  • GC17P047287
  • GC17P042653

Summaries for ABI3 Gene

Entrez Gene Summary for ABI3 Gene

  • This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for ABI3 Gene

ABI3 (ABI Family Member 3) is a Protein Coding gene. An important paralog of this gene is ABI1.

UniProtKB/Swiss-Prot for ABI3 Gene

  • May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.

Gene Wiki entry for ABI3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABI3 Gene

Genomics for ABI3 Gene

Regulatory Elements for ABI3 Gene

Promoters for ABI3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ABI3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ABI3 Gene

Chromosome:
17
Start:
49,210,227 bp from pter
End:
49,223,225 bp from pter
Size:
12,999 bases
Orientation:
Plus strand

Genomic View for ABI3 Gene

Genes around ABI3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABI3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABI3 Gene

Proteins for ABI3 Gene

  • Protein details for ABI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2A4-ABI3_HUMAN
    Recommended name:
    ABI gene family member 3
    Protein Accession:
    Q9P2A4
    Secondary Accessions:
    • C9IZN8
    • Q9H0P6

    Protein attributes for ABI3 Gene

    Size:
    366 amino acids
    Molecular mass:
    39035 Da
    Quaternary structure:
    • May interact with PAK1 and PAK2. Probably interacts with TARSH.

    Alternative splice isoforms for ABI3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABI3 Gene

Proteomics data for ABI3 Gene at MOPED

Post-translational modifications for ABI3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ABI3 Gene

No data available for DME Specific Peptides for ABI3 Gene

Domains & Families for ABI3 Gene

Protein Domains for ABI3 Gene

Suggested Antigen Peptide Sequences for ABI3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P2A4

UniProtKB/Swiss-Prot:

ABI3_HUMAN :
  • Contains 1 SH3 domain.
  • Belongs to the ABI family.
Domain:
  • Contains 1 SH3 domain.
Family:
  • Belongs to the ABI family.
genes like me logo Genes that share domains with ABI3: view

No data available for Gene Families for ABI3 Gene

Function for ABI3 Gene

Molecular function for ABI3 Gene

UniProtKB/Swiss-Prot Function:
May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.
genes like me logo Genes that share phenotypes with ABI3: view

Animal Model Products

miRNA for ABI3 Gene

miRTarBase miRNAs that target ABI3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABI3 Gene

Localization for ABI3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABI3 Gene

Cytoplasm. Note=Colocalizes with PAK2 at leading edge of cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABI3 Gene COMPARTMENTS Subcellular localization image for ABI3 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ABI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 17101133
GO:0005737 cytoplasm IEA,NAS 11956071
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ABI3: view

Pathways & Interactions for ABI3 Gene

SuperPathways for ABI3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ABI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030334 regulation of cell migration IDA 11956071
genes like me logo Genes that share ontologies with ABI3: view

No data available for Pathways by source and SIGNOR curated interactions for ABI3 Gene

Drugs & Compounds for ABI3 Gene

(1) Additional Compounds for ABI3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ABI3: view

Transcripts for ABI3 Gene

Unigene Clusters for ABI3 Gene

ABI family, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABI3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8
SP1: - -
SP2: -
SP3:

Relevant External Links for ABI3 Gene

GeneLoc Exon Structure for
ABI3
ECgene alternative splicing isoforms for
ABI3

Expression for ABI3 Gene

mRNA expression in normal human tissues for ABI3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABI3 Gene

This gene is overexpressed in Whole Blood (x10.1) and Spleen (x8.3).

Protein differential expression in normal tissues from HIPED for ABI3 Gene

This gene is overexpressed in Lymph node (14.2), NK cells (13.8), Spleen (10.4), and CD8 Tcells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ABI3 Gene



SOURCE GeneReport for Unigene cluster for ABI3 Gene Hs.130719

mRNA Expression by UniProt/SwissProt for ABI3 Gene

Q9P2A4-ABI3_HUMAN
Tissue specificity: Expressed in heart, lung, liver, pancreas, kidney, placenta and at low levels in brain and skeletal muscle.
genes like me logo Genes that share expression patterns with ABI3: view

Protein tissue co-expression partners for ABI3 Gene

Primer Products

In Situ Assay Products

Orthologs for ABI3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ABI3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABI3 36
  • 99 (a)
OneToOne
ABI3 35
  • 99.18 (n)
  • 99.45 (a)
cow
(Bos Taurus)
Mammalia ABI3 35
  • 87.08 (n)
  • 89.04 (a)
ABI3 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABI3 36
  • 64 (a)
OneToOne
ABI3 35
  • 86.9 (n)
  • 89.01 (a)
mouse
(Mus musculus)
Mammalia Abi3 16
Abi3 36
  • 86 (a)
OneToOne
Abi3 35
  • 80.85 (n)
  • 83.43 (a)
oppossum
(Monodelphis domestica)
Mammalia ABI3 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABI3 36
  • 32 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abi3 35
  • 80.85 (n)
  • 83.43 (a)
chicken
(Gallus gallus)
Aves ABI3 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ABI3 (1 of 2) 36
  • 34 (a)
OneToMany
ABI3 (2 of 2) 36
  • 26 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Abi 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea abi-1 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for ABI3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ABI3 Gene

ENSEMBL:
Gene Tree for ABI3 (if available)
TreeFam:
Gene Tree for ABI3 (if available)

Paralogs for ABI3 Gene

Paralogs for ABI3 Gene

(6) SIMAP similar genes for ABI3 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ABI3 Gene

genes like me logo Genes that share paralogs with ABI3: view

Variants for ABI3 Gene

Sequence variations from dbSNP and Humsavar for ABI3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2233369 - 49,216,544(+) CAAGC(A/G)GAAGG reference, missense
rs616338 -, - 49,219,935(-) GGGAA(A/G)ACGCA reference, missense
rs659829 -- 49,218,764(-) tagcc(A/G)ggcat intron-variant
rs1009571 -- 49,212,668(+) agctg(A/G)ggttt intron-variant
rs1009572 -- 49,212,709(+) cctag(C/T)tagtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABI3 Gene

Variant ID Type Subtype PubMed ID
nsv2074 CNV Insertion 18451855

Variation tolerance for ABI3 Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.51; 77.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABI3 Gene

HapMap Linkage Disequilibrium report
ABI3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABI3 Gene

Disorders for ABI3 Gene

Relevant External Links for ABI3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABI3

No disorders were found for ABI3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABI3 Gene

Publications for ABI3 Gene

  1. Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells. (PMID: 11956071) Ichigotani Y. … Matsuda S. (Cancer Res. 2002) 2 3 4 67
  2. Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein. (PMID: 10978530) Miyazaki K. … Hamaguchi M. (Biochim. Biophys. Acta 2000) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3
  5. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3

Products for ABI3 Gene

Sources for ABI3 Gene

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