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Aliases for ABI3 Gene

Aliases for ABI3 Gene

  • ABI Family, Member 3 2 3
  • NESH 3 4 6
  • New Molecule Including SH3 3 4
  • ABI Gene Family Member 3 3
  • SSH3BP3 3

External Ids for ABI3 Gene

Previous GeneCards Identifiers for ABI3 Gene

  • GC17P047763
  • GC17P044642
  • GC17P047287
  • GC17P042653

Summaries for ABI3 Gene

Entrez Gene Summary for ABI3 Gene

  • This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for ABI3 Gene

ABI3 (ABI Family, Member 3) is a Protein Coding gene. An important paralog of this gene is ABI2.

UniProtKB/Swiss-Prot for ABI3 Gene

  • May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.

Gene Wiki entry for ABI3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABI3 Gene

Genomics for ABI3 Gene

Regulatory Elements for ABI3 Gene

Genomic Location for ABI3 Gene

Start:
49,210,227 bp from pter
End:
49,223,225 bp from pter
Size:
12,999 bases
Orientation:
Plus strand

Genomic View for ABI3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABI3 Gene

Proteins for ABI3 Gene

  • Protein details for ABI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2A4-ABI3_HUMAN
    Recommended name:
    ABI gene family member 3
    Protein Accession:
    Q9P2A4
    Secondary Accessions:
    • C9IZN8
    • Q9H0P6

    Protein attributes for ABI3 Gene

    Size:
    366 amino acids
    Molecular mass:
    39035 Da
    Quaternary structure:
    • May interact with PAK1 and PAK2. Probably interacts with TARSH.

    Alternative splice isoforms for ABI3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABI3 Gene

Proteomics data for ABI3 Gene at MOPED

Post-translational modifications for ABI3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ABI3 Gene

No data available for DME Specific Peptides for ABI3 Gene

Domains for ABI3 Gene

Protein Domains for ABI3 Gene

Suggested Antigen Peptide Sequences for ABI3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P2A4

UniProtKB/Swiss-Prot:

ABI3_HUMAN :
  • Q9P2A4
Domain:
  • Contains 1 SH3 domain.
Family:
  • Belongs to the ABI family.
genes like me logo Genes that share domains with ABI3: view

No data available for Gene Families for ABI3 Gene

Function for ABI3 Gene

Molecular function for ABI3 Gene

UniProtKB/Swiss-Prot Function: May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.

Gene Ontology (GO) - Molecular Function for ABI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with ABI3: view

Phenotypes for ABI3 Gene

GenomeRNAi human phenotypes for ABI3:
genes like me logo Genes that share phenotypes with ABI3: view

Animal Model Products

CRISPR Products

miRNA for ABI3 Gene

miRTarBase miRNAs that target ABI3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABI3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ABI3 Gene

Localization for ABI3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABI3 Gene

Cytoplasm. Note=Colocalizes with PAK2 at leading edge of cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABI3 Gene COMPARTMENTS Subcellular localization image for ABI3 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ABI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 17101133
GO:0005737 cytoplasm NAS 11956071
GO:0016020 membrane IDA 19946888
GO:0030027 lamellipodium IDA 17101133
genes like me logo Genes that share ontologies with ABI3: view

Pathways for ABI3 Gene

SuperPathways for ABI3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ABI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component NAS 11956071
GO:0018108 NOT peptidyl-tyrosine phosphorylation IDA 17101133
GO:0030334 regulation of cell migration IDA 11956071
genes like me logo Genes that share ontologies with ABI3: view

No data available for Pathways by source for ABI3 Gene

Compounds for ABI3 Gene

(1) Novoseek inferred chemical compound relationships for ABI3 Gene

Compound -log(P) Hits PubMed IDs
abscisic acid 77.6 15
genes like me logo Genes that share compounds with ABI3: view

Transcripts for ABI3 Gene

Unigene Clusters for ABI3 Gene

ABI family, member 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABI3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABI3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8
SP1: - -
SP2: -
SP3:

Relevant External Links for ABI3 Gene

GeneLoc Exon Structure for
ABI3
ECgene alternative splicing isoforms for
ABI3

Expression for ABI3 Gene

mRNA expression in normal human tissues for ABI3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABI3 Gene

This gene is overexpressed in Whole Blood (10.1) and Spleen (8.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABI3 Gene

SOURCE GeneReport for Unigene cluster for ABI3 Gene Hs.130719

mRNA Expression by UniProt/SwissProt for ABI3 Gene

Q9P2A4-ABI3_HUMAN
Tissue specificity: Expressed in heart, lung, liver, pancreas, kidney, placenta and at low levels in brain and skeletal muscle.
genes like me logo Genes that share expressions with ABI3: view

In Situ Assay Products

Orthologs for ABI3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ABI3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABI3 35
  • 99.18 (n)
  • 99.45 (a)
ABI3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ABI3 35
  • 87.08 (n)
  • 89.04 (a)
ABI3 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABI3 35
  • 86.9 (n)
  • 89.01 (a)
ABI3 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abi3 35
  • 80.85 (n)
  • 83.43 (a)
Abi3 16
Abi3 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABI3 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABI3 36
  • 32 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abi3 35
  • 80.85 (n)
  • 83.43 (a)
chicken
(Gallus gallus)
Aves ABI3 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ABI3 (1 of 2) 36
  • 34 (a)
OneToMany
ABI3 (2 of 2) 36
  • 26 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Abi 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea abi-1 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for ABI3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ABI3 Gene

ENSEMBL:
Gene Tree for ABI3 (if available)
TreeFam:
Gene Tree for ABI3 (if available)

Paralogs for ABI3 Gene

Paralogs for ABI3 Gene

Selected SIMAP similar genes for ABI3 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ABI3 Gene

genes like me logo Genes that share paralogs with ABI3: view

Variants for ABI3 Gene

Sequence variations from dbSNP and Humsavar for ABI3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs582824 -- 49,216,508(-) CTGGC(C/T)TAAGG intron-variant
rs597882 -- 49,215,436(-) AATAA(A/G)GAAAC intron-variant
rs609257 -- 49,214,437(-) gccac(C/T)gcgcc intron-variant
rs612062 -- 49,214,575(-) gcacc(A/G)ccacg intron-variant
rs616338 -, - 49,219,935(-) GGGAA(A/G)ACGCA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for ABI3 Gene

Variant ID Type Subtype PubMed ID
nsv2074 CNV Insertion 18451855

Relevant External Links for ABI3 Gene

HapMap Linkage Disequilibrium report
ABI3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABI3 Gene

Disorders for ABI3 Gene

No disorders were found for ABI3 Gene.

No data available for UniProtKB/Swiss-Prot for ABI3 Gene

Publications for ABI3 Gene

  1. Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein. (PMID: 10978530) Miyazaki K. … Hamaguchi M. (Biochim. Biophys. Acta 2000) 2 3 4
  2. Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells. (PMID: 11956071) Ichigotani Y. … Matsuda S. (Cancer Res. 2002) 2 3 4
  3. Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3. (PMID: 11501947) Matsuda S. … Hamaguchi M. (J. Hum. Genet. 2001) 3 4
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ABI3 Gene

Sources for ABI3 Gene

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