Aliases for ABI2 Gene
External Ids for ABI2 Gene
Previous GeneCards Identifiers for ABI2 Gene
GeneCards Summary for ABI2 Gene
ABI2 (Abl-Interactor 2) is a Protein Coding gene. Among its related pathways are Regulation of actin dynamics for phagocytic cup formation and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include ubiquitin protein ligase binding and SH3 domain binding. An important paralog of this gene is ABI3.
UniProtKB/Swiss-Prot for ABI2 Gene
May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.