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Aliases for ABI2 Gene

Aliases for ABI2 Gene

  • Abl-Interactor 2 2 3 5
  • Arg-Binding Protein 1 3 4
  • Abelson Interactor 2 3 4
  • ArgBPIA 3 4
  • ArgBP1 3 4
  • AblBP3 3 4
  • ABI-2 3 4
  • Abl-Interacting Protein 1 (SH3-Containing Protein) 3
  • Arg Protein Tyrosine Kinase-Binding Protein 3
  • Abl-Interactor Protein 2b 3
  • Abl Binding Protein 3 3
  • Abl-Binding Protein 3 4
  • SSH3BP2 3
  • ArgBPIB 3
  • ABI2B 3
  • AIP-1 3

External Ids for ABI2 Gene

Previous GeneCards Identifiers for ABI2 Gene

  • GC02P204368
  • GC02P204018
  • GC02P203901
  • GC02P204192
  • GC02P196040

Summaries for ABI2 Gene

GeneCards Summary for ABI2 Gene

ABI2 (Abl-Interactor 2) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include ubiquitin protein ligase binding and SH3 domain binding. An important paralog of this gene is ABI3.

UniProtKB/Swiss-Prot for ABI2 Gene

  • May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.

Gene Wiki entry for ABI2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABI2 Gene

Genomics for ABI2 Gene

Regulatory Elements for ABI2 Gene

Enhancers for ABI2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ABI2 on UCSC Golden Path with GeneCards custom track

Promoters for ABI2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ABI2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ABI2 Gene

Chromosome:
2
Start:
203,327,874 bp from pter
End:
203,447,723 bp from pter
Size:
119,850 bases
Orientation:
Plus strand

Genomic View for ABI2 Gene

Genes around ABI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABI2 Gene

Proteins for ABI2 Gene

  • Protein details for ABI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYB9-ABI2_HUMAN
    Recommended name:
    Abl interactor 2
    Protein Accession:
    Q9NYB9
    Secondary Accessions:
    • B4DSN1
    • Q13147
    • Q13249
    • Q13801
    • Q9BV70

    Protein attributes for ABI2 Gene

    Size:
    513 amino acids
    Molecular mass:
    55663 Da
    Quaternary structure:
    • Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterdimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1 (By similarity). Interacts with ABL1 and ABL2. Interacts with human cytomegalovirus UL135.

    Three dimensional structures from OCA and Proteopedia for ABI2 Gene

    Alternative splice isoforms for ABI2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABI2 Gene

Proteomics data for ABI2 Gene at MOPED

Post-translational modifications for ABI2 Gene

No data available for DME Specific Peptides for ABI2 Gene

Domains & Families for ABI2 Gene

Protein Domains for ABI2 Gene

Suggested Antigen Peptide Sequences for ABI2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYB9

UniProtKB/Swiss-Prot:

ABI2_HUMAN :
  • Contains 1 SH3 domain.
  • Belongs to the ABI family.
Domain:
  • Contains 1 SH3 domain.
  • Contains 1 t-SNARE coiled-coil homology domain.
Family:
  • Belongs to the ABI family.
genes like me logo Genes that share domains with ABI2: view

No data available for Gene Families for ABI2 Gene

Function for ABI2 Gene

Molecular function for ABI2 Gene

UniProtKB/Swiss-Prot Function:
May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.

Gene Ontology (GO) - Molecular Function for ABI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019900 kinase binding NAS 8649853
GO:0048365 contributes_to Rac GTPase binding IDA 21107423
genes like me logo Genes that share ontologies with ABI2: view
genes like me logo Genes that share phenotypes with ABI2: view

Animal Models for ABI2 Gene

MGI Knock Outs for ABI2:

Animal Model Products

miRNA for ABI2 Gene

miRTarBase miRNAs that target ABI2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ABI2 Gene

Localization for ABI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABI2 Gene

Cytoplasm.
Isoform 1: Cell projection, lamellipodium. Cell projection, filopodium. Cytoplasm, cytoskeleton. Note=Isoform 1 but not isoform 3 is localized to protruding lamellipodia and filopodia tips. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABI2 Gene COMPARTMENTS Subcellular localization image for ABI2 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 3
extracellular 1

Gene Ontology (GO) - Cellular Components for ABI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,TAS 8649853
GO:0030027 lamellipodium IDA 11516653
genes like me logo Genes that share ontologies with ABI2: view

Pathways & Interactions for ABI2 Gene

genes like me logo Genes that share pathways with ABI2: view

Pathways by source for ABI2 Gene

Gene Ontology (GO) - Biological Process for ABI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
GO:0016601 Rac protein signal transduction IDA 21107423
GO:0018108 peptidyl-tyrosine phosphorylation IDA 17101133
genes like me logo Genes that share ontologies with ABI2: view

No data available for SIGNOR curated interactions for ABI2 Gene

Drugs & Compounds for ABI2 Gene

(1) Drugs for ABI2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ABI2: view

Transcripts for ABI2 Gene

Unigene Clusters for ABI2 Gene

Abl-interactor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABI2 Gene

No ASD Table

Relevant External Links for ABI2 Gene

GeneLoc Exon Structure for
ABI2
ECgene alternative splicing isoforms for
ABI2

Expression for ABI2 Gene

mRNA expression in normal human tissues for ABI2 Gene

Protein differential expression in normal tissues from HIPED for ABI2 Gene

This gene is overexpressed in Fetal Brain (20.1), Frontal cortex (17.3), and Brain (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABI2 Gene



SOURCE GeneReport for Unigene cluster for ABI2 Gene Hs.471156

genes like me logo Genes that share expression patterns with ABI2: view

Protein tissue co-expression partners for ABI2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ABI2 Gene

Orthologs for ABI2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ABI2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ABI2 35
  • 96.07 (n)
  • 99.37 (a)
ABI2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abi2 35
  • 92.3 (n)
  • 97.76 (a)
Abi2 16
Abi2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abi2 35
  • 90.98 (n)
  • 96.72 (a)
dog
(Canis familiaris)
Mammalia ABI2 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABI2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABI2 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ABI2 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves ABI2 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABI2 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia lan4-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5926 35
zebrafish
(Danio rerio)
Actinopterygii abi2a 35
  • 73.85 (n)
  • 85.41 (a)
abi2a 36
  • 84 (a)
OneToMany
abi2b 36
  • 71 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001046 35
  • 52.39 (n)
  • 50.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta Abi 35
  • 55.24 (n)
  • 55.71 (a)
Abi 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea abi-1 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for ABI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABI2 Gene

ENSEMBL:
Gene Tree for ABI2 (if available)
TreeFam:
Gene Tree for ABI2 (if available)

Paralogs for ABI2 Gene

Paralogs for ABI2 Gene

genes like me logo Genes that share paralogs with ABI2: view

Variants for ABI2 Gene

Sequence variations from dbSNP and Humsavar for ABI2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs723115 -- 203,415,879(-) TATAG(C/T)AACAT intron-variant
rs1802776 -- 203,380,310(+) CCAAC(C/T)TTGAA reference, missense, utr-variant-5-prime
rs2882829 -- 203,412,926(+) ACATA(C/T)TCCAT intron-variant
rs998027 -- 203,406,494(+) AAAGC(C/G)ACTAA intron-variant
rs1982417 -- 203,406,618(+) AAGAA(A/T)ACTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABI2 Gene

Variant ID Type Subtype PubMed ID
nsv3115 CNV Loss 18451855
nsv875718 CNV Gain 21882294

Variation tolerance for ABI2 Gene

Residual Variation Intolerance Score: 18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABI2 Gene

HapMap Linkage Disequilibrium report
ABI2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABI2 Gene

Disorders for ABI2 Gene

Relevant External Links for ABI2

Genetic Association Database (GAD)
ABI2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABI2

No disorders were found for ABI2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABI2 Gene

Publications for ABI2 Gene

  1. Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity. (PMID: 7590236) Dai Z. … Pendergast A.M. (Genes Dev. 1995) 2 3 4 23 67
  2. The expression of Abl interactor 2 in leiomyoma and myometrium and regulation by GnRH analogue and transforming growth factor-beta. (PMID: 16488906) Luo X. … Chegini N. (Hum. Reprod. 2006) 3 23
  3. Screen and identification of proteins interacting with ADAM19 cytoplasmic tail. (PMID: 12463424) Huang L. … Li C. (Mol. Biol. Rep. 2002) 3 23
  4. A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium. (PMID: 10964520) Machado R.D. … Nichols W.C. (Genomics 2000) 2 3
  5. Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene. (PMID: 8649853) Wang B. … Kruh G.D. (Oncogene 1996) 3 23

Products for ABI2 Gene

Sources for ABI2 Gene

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