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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ABI1 Gene

protein-coding GIFtS: 60
GCID: GC10M027075

abl-interactor 1

(Previous name: spectrin SH3 domain binding protein 1 )
(Previous symbol: SSH3BP1)

Explore 19 diseases affiliated with
ABI1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Abl-Interactor 1¹ ²		SSH3BP²
SSH3BP1¹ ² ³		Abl Interactor 1²
ABI-1¹ ²		Abl-Interactor Protein 1 Long²
E3B1¹ ²		Interactor Protein AblBP4²
Abl-Binding Protein 4² ³		Nap1 Binding Protein²
Eps8 SH3 Domain-Binding Protein² ³		Abi-1³
Spectrin SH3 Domain-Binding Protein 1² ³		AblBP4³
Abelson Interactor 1² ³		Nap1BP³
Spectrin SH3 Domain Binding Protein 1¹		E3B1¹ ²
ABLBP4²		Eps8-Binding Protein³
NAP1BP²		Nap1-Binding Protein³

External Ids:	HGNC: 11320¹	Entrez Gene: 10006²	Ensembl: ENSG00000136754⁷	OMIM: 603050⁵	UniProtKB: Q8IZP0³

Export aliases for ABI1 gene to outside databases

Previous GC identifers: GC10M027040 GC10M026695

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ABI1:

This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal

transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal

remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as

a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from

Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and

breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with

acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for

this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. (provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: ABI1_HUMAN, Q8IZP0

Function: May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine

kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in

cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to

Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor

(GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1-mediated phosphorylation of ENAH.

Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level (By similarity)

Gene Wiki entry for ABI1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_008705.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ABI1 gene promoter:
USF1 LHX3b/Lhx3b ATF-2 MEF-2 USF2 GATA-1 MEF-2A LHX3a/Lhx3a ZID aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ABI1 promoter sequence

Search SABiosciences Chromatin IP Primers for ABI1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABI1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p11.2 Ensembl cytogenetic band: 10p12.1 HGNC cytogenetic band: 10p12.1

ABI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABI1 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M027075: view genomic region (about GC identifiers)

Start:	27,035,522 bp from pter	End:	27,150,016 bp from pter
Size:	114,495 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ABI1_HUMAN, Q8IZP0 (See protein sequence)

Recommended Name: Abl interactor 1

Size: 508 amino acids; 55081 Da

Subunit: Interacts with ABL1, ENAH, STX1A, SNAP25, VAMP2, EPS8, and through its N-terminus with WASF1. Part of a

complex consisting of ABI1, STX1A and SNAP25. Part of a complex consisting of ABI1, EPS8 and SOS1 (By similarity).

Interacts with SOS1, SOS2, GRB2, SPTA1 and the first SH3 domain of NCK1. Isoform 6 does not interact with NCK1.

Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2

Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Cell projection, lamellipodium (By

similarity). Cell projection, filopodium (By similarity). Cell projection, growth cone (By similarity). Cell junction,

synapse, synaptosome (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Localized to protruding

lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes (By similarity)

Secondary accessions: A9Z1Y6 B3KX62 B4DQ58 H7BXI6 O15147 O76049 O95060 Q5T2R3 Q5T2R4 Q5T2R6 Q5T2R7

Q5T2R9 Q5W070 Q5W072 Q8TB63 Q96S81 Q9NXZ9 Q9NYB8

Alternative splicing: 12 isoforms: Q8IZP0-1 Q8IZP0-2 Q8IZP0-3 Q8IZP0-4 Q8IZP0-5 Q8IZP0-6 Q8IZP0-7 Q8IZP0-8

Q8IZP0-9 Q8IZP0-10 Q8IZP0-11 Q8IZP0-12 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ABI1: NX_Q8IZP0

Post-translational modifications:

In vitro substrate for v-Abl (By similarity). Phosphorylated on tyrosine residues after serum stimulation or induction

by v-Abl¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IZP0

ABI1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (12 alternative transcripts):

NP_001012768.1 NP_001012769.1 NP_001012770.1 NP_001171587.1 NP_001171590.1 NP_001171591.1 NP_001171592.1 NP_001171593.1

NP_001171594.1 NP_001171595.1 NP_001171596.1 NP_005461.2

ENSEMBL proteins:

ENSP00000365308 ENSP00000365340 ENSP00000365336 ENSP00000365330 ENSP00000365312

ENSP00000352114 ENSP00000365309 ENSP00000365310 ENSP00000347555 ENSP00000279599

ENSP00000365304 ENSP00000365307 ENSP00000439646 ENSP00000440101

Reactome Protein details: Q8IZP0
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): ABI1 OriGene Protein Over-expression Lysate (see all 7): ABI1 OriGene Custom Protein Services for ABI1
	GenScript Custom Purified and Recombinant Proteins Services for ABI1
	Novus Biologicals ABI1 Protein Novus Biologicals ABI1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ABI1

Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IDA	17101133
GO:0005625	soluble fraction	--	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	--	--
GO:0005783	endoplasmic reticulum	TAS	9593709

ABI1 for ontologies About GeneDecksing

ABI1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ABI1
	Browse R&D Systems for Antibodies
	OriGene Antibodies: ABI1 OriGene Custom Antibody Services for ABI1
	GenScript Custom Superior Antibodies Services for ABI1
	Novus Biologicals ABI1 Antibodies
	Abcam antibodies for ABI1
	Uscn Antibodies for ABI1
	Search ThermoFisher Antibodies for ABI1

Assay Products for ABI1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ABI1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ABI1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ABI1 for domains About GeneDecksing

4 InterPro domains/families:

IPR000727 T_SNARE_dom

IPR012849 Abl-interactor_HHR_dom

IPR000108 p67phox

IPR001452 SH3_domain

Graphical View of Domain Structure for InterPro Entry Q8IZP0

ProtoNet protein and cluster: Q8IZP0

3 Blocks protein families:

IPB001452 SH3 domain signature

IPB011511 Variant SH3

IPB012849 Abl-interactor HHR

UniProtKB/Swiss-Prot: ABI1_HUMAN, Q8IZP0

Domain: The t-SNARE coiled-coil homology domain is necessary and sufficient for interaction with STX1A (By similarity)

Similarity: Belongs to the ABI family

Similarity: Contains 1 SH3 domain

Similarity: Contains 1 t-SNARE coiled-coil homology domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ABI1_HUMAN, Q8IZP0

Function: May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine

kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in

cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to

Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor

(GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1-mediated phosphorylation of ENAH.

Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level (By similarity)

miRNA Products:		OriGene 3'-UTR Clone (see all 4): ABI1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ABI1
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate ABI1 (see all 23):
		hsa-miR-181c hsa-miR-340 hsa-miR-519a hsa-miR-9 hsa-miR-15b* hsa-miR-205* hsa-miR-1252 hsa-miR-3148

		SwitchGear 3'UTR luciferase reporter plasmid: ABI1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABI1 (see all 7) OriGene shRNA RFP: ABI1 OriGene siRNA: ABI1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABI1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ABI1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABI1 (see all 18) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABI1 (see all 12) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 12): ABI1 (NM_005470)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABI1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABI1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ABI1
		Search LifeMap BioReagents cell lines for ABI1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABI1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0008092	cytoskeletal protein binding	TAS	9593709
GO:0030296	protein tyrosine kinase activator activity	IEA	--

ABI1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for ABI1: Abi1^tm1.2Lko Abi1^tm1Pen
     11 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Abi1):

cardiovascular system	cellular	craniofacial	embryogenesis	growth/size
hematopoietic system	homeostasis/metabolism	immune system	mortality/aging	nervous system
no phenotypic analysis

ABI1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Regulation of actin dynamics for phagocytic cup formation

	Regulation of actin dynamics for phagocytic cup formation	1.00			Fcgamma receptor (FCGR) dependent phagocytosis	0.80
	Role of myosins in phagosome formation	0.80			Branching and elongation of mother and daughter filaments	0.29

Development FGFR signaling pathway

Development FGFR signaling pathway

1.00

Development_FGFR signaling pathway

0.98

Immune System

Immune System

1.00

Innate Immune System

0.46

Development HGF signaling pathway

Development EGFR signaling via small GTPases

0.44

Development_EGFR signaling via small GTPases

0.44

EGFR1 Signaling Pathway

EGFR1 Signaling Pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for ABI1

	Development EGFR signaling via small GTPases
	Development FGFR signaling pathway

2 GeneGo (Thomson Reuters) Pathways for ABI1

	Development EGFR signaling via small GTPases
	Development FGFR signaling pathway

5/6 BioSystems Pathways for ABI1 (see all 6)

	EGFR1 Signaling Pathway
	Stabilization and expansion of the E-cadherin adherens junction
	Regulation of RAC1 activity
	RAC1 signaling pathway
	ErbB1 downstream signaling

5/6 Reactome Pathways for ABI1 (see all 6)

	Role of myosins in phagosome formation
	Branching and elongation of mother and daughter filaments
	Regulation of actin dynamics for phagocytic cup formation
	Fcgamma receptor (FCGR) dependent phagocytosis
	Immune System

ABI1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ABI1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/121 Interacting proteins for ABI1 (Q8IZP0^{1, 2, 3} ENSP00000365312⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 121)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABL1	P00519¹^,²^,³, ENSP00000361423⁴	EBI-375446,EBI-1550796 MINT-7385805 MINT-7385781 MINT-3390323 MINT-7907945 MINT-7385753 MINT-7385822 MINT-7385733 MINT-3390262 I2D: score=7 STRING: ENSP00000361423
PIK3R1	P27986²^,³, ENSP00000274335⁴	MINT-7907848 MINT-7907881 MINT-7907897 MINT-7907913 MINT-7907832 MINT-7907865 MINT-7907815 MINT-7907929 I2D: score=1 STRING: ENSP00000274335
EPS8	Q12929²^,³, ENSP00000281172⁴	MINT-15663 MINT-15665 MINT-15664 I2D: score=5 STRING: ENSP00000281172
ABL2	P42684²^,³, ENSP00000356595⁴	MINT-7908314 MINT-7908442 I2D: score=1 STRING: ENSP00000356595
SOCS7	O14512²^,³, ENSP00000330659⁴	MINT-7908538 MINT-7908139 I2D: score=1 STRING: ENSP00000330659

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001756	somitogenesis	IEA	--
GO:0006928	cellular component movement	IDA	11516653
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	TAS	9010225
GO:0008154	actin polymerization or depolymerization	NAS	11516653
GO:0008285	negative regulation of cell proliferation	TAS	9010225

ABI1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ABI1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ABI1

3 HMDB Compounds for ABI1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

7 Novoseek chemical compound relationships for ABI1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
af 10	78.9	3	11477655 (2)
abscisic acid	74.3	24	11208021 (6), 9090884 (4), 19407143 (3), 10488243 (2) (see all 6)
tyrosine	39.9	9	17389688 (2), 16899465 (1), 15657136 (1), 11418237 (1) (see all 5)
phosphoinositide	27.3	2	12515821 (1), 17389688 (1)
proline	21.1	5	9694699 (2), 11477655 (1)
threonine	15.4	1	11208021 (1)
serine	0	1	11208021 (1)

Search CenterWatch for drugs/clinical trials and news about ABI1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ABI1 gene (12 alternative transcripts):

NM_001012750.2 NM_001012751.2 NM_001012752.2 NM_001178116.1 NM_001178119.1 NM_001178120.1 NM_001178121.1 NM_001178122.1

NM_001178123.1 NM_001178124.1 NM_001178125.1 NM_005470.3

Unigene Cluster for ABI1:

Abl-interactor 1

Hs.508148 [show with all ESTs]

Unigene Representative Sequence: NM_005470

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000376138(uc010qdg.2) ENST00000376170 ENST00000376166 ENST00000376160

ENST00000376142 ENST00000359188 ENST00000376139 ENST00000376140 ENST00000473481

ENST00000355394(uc001isx.3) ENST00000346832(uc001itb.3 uc001itd.3 uc001ita.3 uc010qdk.2)

ENST00000376134(uc001ite.3 uc001itc.3 uc001isy.3 uc001isz.3)

ENST00000376137(uc010qdj.2) ENST00000536334(uc010qdh.2) ENST00000490841(uc010qdi.2)

miRNA Products:		OriGene 3'-UTR Clone (see all 4): ABI1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ABI1
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate ABI1 (see all 23):
		hsa-miR-181c hsa-miR-340 hsa-miR-519a hsa-miR-9 hsa-miR-15b* hsa-miR-205* hsa-miR-1252 hsa-miR-3148

		SwitchGear 3'UTR luciferase reporter plasmid: ABI1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABI1 (see all 7) OriGene shRNA RFP: ABI1 OriGene siRNA: ABI1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABI1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABI1 (see all 18) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABI1 (see all 12) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 12): ABI1 (NM_005470)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABI1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABI1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABI1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ABI1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABI1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABI1

Additional cDNA sequence:

AB040151.1 AB209268.1 AF001628.1 AF006516.1 AF090888.1 AF260262.1 AF540955.1 AK126803.1

AK291823.1 AK296751.1 AK298646.1 AK315914.1 BC013238.1 BC024254.2 FJ380057.1 FJ380058.1

FJ380059.1 U87166.1

20 DOTS entries:

DT.99955725 DT.101986500 DT.100827868 DT.117833 DT.97857274 DT.95295998 DT.101986503 DT.100827864

DT.92051985 DT.121230422 DT.121230445 DT.102833994 DT.75159975 DT.101970662 DT.95261182 DT.100827862

DT.121230408 DT.121230421 DT.121230461 DT.97847417

24/359 AceView cDNA sequences (see all 359):

AW583936 AI802109 CA431271 AU139442 AW512180 AA322376 BP372238 CA306697

BX493519 BU753342 AA513423 AA857577 AB040151 AI381214 AK126803 AA504103

AA731455 AW074692 AI699080 BE886808 AI360798 CA945089 AA603947 AA313543

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ABI1 (see all 12) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c	·	8d	·	8e	^	9a	·	9b	^	10a	·	10b	·	10c	·	10d	^	11	^	12	^	13a	·	13b	^	14a	·	14b	^
SP1:							-		-		-				-		-																												-
SP2:							-		-		-				-		-																												-		-
SP3:									-						-		-
SP4:																																													-		-
SP5:																																													-		-

ExUns:	15a	·	15b	·	15c	·	15d
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for ABI1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ABI1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACTTTGTGT

About this image
See ABI1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ABI1

SOURCE GeneReport for Unigene cluster: Hs.508148

UniProtKB/Swiss-Prot: ABI1_HUMAN, Q8IZP0

Tissue specificity: Widely expressed, with highest expression in brain

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for ABI1 gene from 7/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Abi1^{1 , 5}	abl-interactor 1^{1, 5}	92.38(n)¹ 98.34(a)¹		2 (15.18 cM)⁵ 11308¹ NM_001077190.1¹ NP_001070658.1¹ 22940073⁵
chicken (Gallus gallus)	Aves	ABI1¹	abl-interactor 1	86.68(n) 96.46(a)		420489 XM_001233768.2 XP_001233769.1
lizard (Anolis carolinensis)	Reptilia	ABI1⁶	--	95(a)	1 ↔ 1	6(14588682-14655950)
African clawed frog (Xenopus laevis)	Amphibia	Xl.7665²	Xenopus laevis transcribed sequence with strong similarity to protein refNP_005461.1 (H.sapiens) spectrin SH3 domain binding protein 1; eps8 binding protein; interactor protein AblBP4; Abl-interactor protein 1 long [Homo sapiens] less	81.22(n)		BX851571.1
zebrafish (Danio rerio)	Actinopterygii	zgc73174²	hypothetical protein MGC73174	75.23(n)		393711 BC059524.1
fruit fly (Drosophila melanogaster)	Insecta	Abi⁶	Abelson interacting protein	39(a)	1 → many	3R(9944984-9948142)
worm (Caenorhabditis elegans)	Secernentea	abi-1⁶	ABl Interactor homolog family member (abi-1)	32(a)	1 → many	III(5690062-5692695)

ENSEMBL Gene Tree for ABI1 (if available)
TreeFam Gene Tree for ABI1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ABI1 gene

ABI2² ABI3²

10 SIMAP similar genes for ABI1 using alignment to 6 protein entries: ABI1_HUMAN (see all proteins):

ABI-2 ABI2 SH3GL1 SH3RF3 ARHGEF7 SH3GL2

ITSN2 argBPIB SORBS3 ABI3

ABI1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ABI1
PGOHUM00000248179

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74547466^1,2	C,	--	26696065(+)	`AGTCTG/TCNNNN`	12	--	ut3¹		0	--	--	--	--
rs10829056^1,2	C,F,A,H,	--	26696557(+)	`GCATTT/ATGATT`	12	--	ut3¹		11		NA NS EA WA	800
rs17128562^1,2	F	--	26697197(-)	`AAAAGC/AAGCAA`	24	--	ut3¹		1		MN	184
rs201976123^1,2	C	--	26697199(-)	`TGAAAC/GAAGCA`	12	--	ut3¹		0	--	--	--	--
rs112276714^1,2		--	26697562(+)	`TACATG/AAGCAT`	12	--	ut3¹		1		CSA	2
rs112579950^1,2	C,	--	26698215(+)	`GCTCTC/TTGAAT`	12	--	int¹		1		NA	2
rs74512123^1,2	F,	--	26698893(+)	`CTATAT/CTCACT`	12	--	int¹		1		NA	120
rs12784414^1,2	H	--	26698993(+)	`aaaggT/Gttatt`	12	--	int¹		4		NS EA	402
rs79967259^1,2	F,	--	26699188(+)	`CTACTA/GTCAAA`	12	--	int¹		1		EA	120
rs76466779^1,2	F,	--	26700112(+)	`TGAAAT/CACAAT`	12	--	int¹		1		EA	120

HapMap Linkage Disequilibrium report for ABI1 (27035522 - 27150016 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ABI1
1 CNV: 70942

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ABI1 for disorders About GeneDecksing

OMIM gene information: 603050 OMIM disorders: --

UniProtKB/Swiss-Prot: ABI1_HUMAN, Q8IZP0

Note=A chromosomal aberration involving ABI1 is a cause of acute leukemias. Translocation t(10;11)(p11.2;q23)

with MLL. ABI1 isoform 2 was found to be present in acute leukemia MLL-ABI1 fusion transcript

19 diseases for ABI1: About MalaCards

acute myeloid leukemia myeloid leukemia human granulocytic anaplasmosis breast cancer

leukemia monocytic leukemia colon cancer acute monocytic leukemia

macular degeneration melanoma cblc noma

acute leukemia hepatocellular carcinoma alzheimer's disease gastric cancer

ataxia carcinoma neuronitis

2 Novoseek disease relationships for ABI1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemogenesis	62	1	9694699 (1)
leukemia	19.5	5	11477655 (2), 12547160 (1)

Human Genome Epidemiology (HuGE) Navigator: ABI1 (2 documents)

Export disorders for ABI1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ABI1 gene, integrated from 9 sources (see all 94):
(articles sorted by number of sources associating them with ABI1)

Utopia: connect your pdf to the dynamic
world of online information

Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth. (PubMed id 9010225)^{1, 2, 3, 9} Biesova Z....Wong W.T. (1997)
Identification of a candidate human spectrin Src homology 3 domain- binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton. (PubMed id 9593709)^{1, 2, 3} Ziemnicka-Kotula D.... Kotula L. (1998)
ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23). (PubMed id 9694699)^{1, 2, 9} Taki T.... Hayashi Y. (1998)
Abl interactor 1 binds to sos and inhibits epidermal growth factor- and v-Abl-induced activation of extracellular signal-regulated kinases. (PubMed id 11003655)^{1, 2, 9} Fan P.-D. and Goff S.P. (2000)
Isolation of hNap1BP which interacts with human Nap 1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease. (PubMed id 11418237)^{1, 2, 9} Yamamoto A.... Sakaki Y. (2001)
Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1. (PubMed id 18328268)^{1, 2} Xiong X....Kotula L. (2008)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{1, 2} Deloukas P.... Rogers J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Induction of colonic epithelial cell apoptosis by p47-dependent oxidants(1). (PubMed id 12681507)^{1, 2} Gu Y.... Terada L.S. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10006	HGNC: 11320	AceView: ABI1	Ensembl:ENSG00000136754	euGenes: HUgn10006
ECgene: ABI1	H-InvDB: ABI1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ABI1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ABI1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ABI1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ABI1 gene:
Search GeneIP for patents involving ABI1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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ABI1 Gene

abl-interactor 1

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ABI1 (Gene Symbol)
Abl-Interactor 1
SSH3BP1
ABI-1
E3B1
Abl-Binding Protein 4
Eps8 SH3 Domain-Binding Protein
Spectrin SH3 Domain-Binding Protein 1
Abelson Interactor 1
Spectrin SH3 Domain Binding Protein 1
ABLBP4
NAP1BP
SSH3BP
Abl Interactor 1
Abl-Interactor Protein 1 Long
Interactor Protein AblBP4
Nap1 Binding Protein
Abi-1
AblBP4
Nap1BP
E3B1
Eps8-Binding Protein
Nap1-Binding Protein

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ABI1 Gene

abl-interactor 1

Aliasesfor ABI1 gene

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