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ABI1 Gene

protein-coding GIFtS: 60

GC10M027075

abl-interactor 1
(Previous name: spectrin SH3 domain binding protein 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SSH3BP1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ABI-1 ^¹, ²
Abi-1 ^³
AblBP4 ^³
E3B1 ^¹, ²
NAP1BP ^²
Nap1BP ^³
OTTHUMP00000019352 ^²
OTTHUMP00000019355 ^²
SSH3BP ^²
SSH3BP1 ^², ³
e3B1 ^³

Descriptions
Abelson interactor 1 ^², ³
Abl-binding protein 4 ^³
Abl-interactor protein 1 long ^²
Eps8 SH3 domain-binding protein ^³
Eps8-binding protein ^³
Nap1-binding protein ^³
Spectrin SH3 domain-binding protein 1 ^³
abl-interactor 1 ^²
eps8 binding protein ^²
interactor protein AblBP4 ^²
nap1 binding protein ^²
spectrin SH3 domain binding protein 1 ^¹, ²

External Ids
HGNC: 11320¹
Entrez Gene: 10006²
UniProtKB: Q8IZP0³
Ensembl: ENSG00000136754⁷

Search outside databases for aliases for ABI1 gene

Previous GC identifer: GC10M027040

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABI1:

The protein encoded by this gene has been found to form a complex with EPS8 and SOS1, and is

thought to be involved in the transduction of signals from Ras to Rac. In addition, the encoded

protein may play a role in the regulation of EGF-induced Erk pathway activation as well as

cytoskeletal reorganization and EGFR signaling. Several transcript variants encoding multiple

isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: ABI1_HUMAN, Q8IZP0

Function: May act in negative regulation of cell growth and transformation by interacting with

nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk

pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8

participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1,

EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1

seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.

Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level (By similarity)

Gene Wiki entry for ABI1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ABI1 gene

Entrez Gene cytogenetic band: 10p11.2 Ensembl cytogenetic band: 10p12.1 HGNC cytogenetic band: 10p12.1

ABI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M027075: (about GC identifiers)

Start:	27,075,528 bp from pter
End:	27,189,965 bp from pter
Size:	114,438 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_008705.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ABI1_HUMAN, Q8IZP0 (See protein sequence)

Recommended Name: Abl interactor 1

Size: 508 amino acids; 55081 Da

Subunit: Interacts with ABL1, MENA, STX1A, SNAP25, VAMP2, EPS8, and through its N-terminus with

WASF1. Part of a complex consisting of ABI1, STX1A and SNAP25. Part of a complex consisting of

ABI1, EPS8 and SOS1 (By similarity). Interacts with SOS1, SOS2, GRB2, SPTA1 and the first SH3

domain of NCK1. Isoform 6 does not interact with NCK1. Component of the WAVE2 complex composed of

ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2

Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Cell projection,

lamellipodium (By similarity). Cell projection, filopodium (By similarity). Cell projection,

growth cone (By similarity). Cell junction, synapse, synaptosome (By similarity). Cytoplasm,

cytoskeleton (By similarity). Note=Localized to protruding lamellipodia and filopodia tips. Also

localized to neuronal growth cones and synaptosomes (By similarity)

Secondary accessions: O15147 O76049 O95060 Q5W070 Q5W072 Q8TB63 Q96S81 Q9NXZ9 Q9NYB8

Alternative splicing: 10 isoforms: Q8IZP0-1 Q8IZP0-2 Q8IZP0-3 Q8IZP0-4 Q8IZP0-5 Q8IZP0-6 Q8IZP0-7 Q8IZP0-8

Q8IZP0-9 Q8IZP0-10 (Additional isoforms seem to exist)

Post-translational modifications:

In vitro substrate for v-Abl (By similarity). Phosphorylated on tyrosine residues after serum

stimulation or induction by v-Abl¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001012768.1 NP_001012769.1 NP_001012770.1 NP_005461.2

ENSEMBL proteins:

ENSP00000365330 ENSP00000352114 ENSP00000365336 ENSP00000279599 ENSP00000365304 ENSP00000365312

ENSP00000347555 ENSP00000365308 ENSP00000365310 ENSP00000365309 ENSP00000365340 ENSP00000365305

ENSP00000365307

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (SSH3BP1)
	Human Recombinant Proteins from Abnova (ABI1)

OriGene Purified Recombinant Human Proteins (see all 2): ABI1

5/11 Gene Ontology (GO) cellular component terms (links to tree view) (see all 11 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IDA	17101133
GO:0005625	soluble fraction	TAS	9010225
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005783	endoplasmic reticulum	TAS	9593709

About this table

Antibodies for ABI1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ABI1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (SSH3BP1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ABI1)
	Novus Biologicals Antibodies for ABI1

Assays for ABI1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8IZP0

ProtoNet protein and cluster: Q8IZP0

3 Blocks protein families:

IPB001452 SH3 domain signature

IPB011511 Variant SH3

IPB012849 Abl-interactor HHR

UniProtKB/Swiss-Prot: ABI1_HUMAN, Q8IZP0

Domain: The t-SNARE coiled-coil homology domain is necessary and sufficient for interaction with

STX1A (By similarity)

Similarity: Belongs to the ABI family

Similarity: Contains 1 SH3 domain

Similarity: Contains 1 t-SNARE coiled-coil homology domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABI1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001012750

Applied Biosystems Silencer® siRNAs for ABI1

Sigma-Aldrich siRNA for ABI1

Sigma-Aldrich shRNA Panels and shRNA for ABI1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ABI1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001012750
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001012750
untagged cDNA clones in CMV expression vector (see all 4): NM_001012750

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005470

UniProtKB/Swiss-Prot: ABI1_HUMAN, Q8IZP0

Function: May act in negative regulation of cell growth and transformation by interacting with

nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk

pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8

participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1,

EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1

seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.

Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level (By similarity)

1 MGI phenotypic allele for Abi1 (no phenotypes)

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008092	cytoskeletal protein binding	TAS	9593709

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for ABI1 (Your Favorite Gene powered by Ingenuity)

Macropinocytosis
Ephrin Receptor Signaling

GeneDecks ABI1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ABI1

5/43 Interacting proteins for ABI1 (ENSP00000347555³ Q8IZP0^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 43 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BAIAP2	Q9UQB8¹	STRING (score=.936) EBI-375446, EBI-525456
NCK1	P16333¹	STRING (score=.753) EBI-375446, EBI-389883
WASF2	Q9Y6W5²	STRING (score=.998) MINT-45987 MINT-45991 MINT-3390382 MINT-45984
EPS8	Q12929²	STRING (score=.999) MINT-15665 MINT-15663 MINT-15664
SOS1	Q07889²	STRING (score=.953) MINT-16552 MINT-16551

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	TAS	9010225
GO:0008285	negative regulation of cell proliferation	TAS	9010225
GO:0018108	peptidyl-tyrosine phosphorylation	IDA	17101133

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ABI1
6 Novoseek chemical compound relationships for ABI1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
af 10	79.92	3	11477655 (2)
abscisic acid	73.71	20	11208021 (6), 9090884 (4), 10488243 (2), 16571665 (1) (see all 5)
tyrosine	41.55	9	17389688 (2), 16899465 (1), 15657136 (1), 11418237 (1) (see all 5)
phosphoinositide	29.20	2	12515821 (1), 17389688 (1)
proline	23.00	5	9694699 (2), 11477655 (1)
threonine	17.22	1	11208021 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABI1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001012750

Sigma-Aldrich siRNA for ABI1

Sigma-Aldrich shRNA Panels and shRNA for ABI1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001012750 NM_001012751 NM_001012752 NM_005470

REFSEQ mRNAs for ABI1 gene (4 alternative transcripts):

NM_001012750.1 NM_001012751.1 NM_001012752.1 NM_005470.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001012750 NM_001012751 NM_001012752 NM_005470

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001012750
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001012750
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001012750

Additional cDNA sequence:

AB040151.1 AB209268.1 AF001628.1 AF006516.1 AF090888.1 AF260262.1 AF540955.1 AK126803.1

AK291823.1 AK296751.1 AK298646.1 AK315914.1 BC013238.1 BC024254.2 CR622396.1 FJ380057.1

FJ380058.1 FJ380059.1 U87166.1

21 DOTS entries:

DT.99955725 DT.101986500 DT.100827868 DT.97857274 DT.117833 DT.95295998 DT.101986503 DT.100827864

DT.92051985 DT.95326560 DT.121230422 DT.121230445 DT.102833994 DT.75159975 DT.95261182 DT.101970662

DT.100827862 DT.121230421 DT.121230461 DT.121230408 DT.97847417

24/359 AceView cDNA sequences (see all 359 ):

AW074692 AW080248 AA731455 BU729983 AI381214 AI891112 BM715247 AF540955

AI678447 BF111123 BQ948892 AI699080 AW468079 AI359390 BQ773797 AW131231

AU280483 BP349054 CB054534 CF541195 AW193581 BI763572 AW583936 AW512180

highest scoring ESTs for ABI1:

AF001628 AU100161 AW401409 AW401961 BE154550 BM752806 BM785682 AA232072 AA496772 AB040151

Unigene Cluster for ABI1:

Abl-interactor 1

Hs.508148 [show with all ESTs]

Unigene Representative Sequence: NM_005470

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ABI1 (see all 12 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c	·	8d	·	8e	^	9a	·	9b	^	10a	·	10b	·	10c	·	10d	^	11	^	12	^	13a	·	13b	^	14a	·	14b	^
SP1:							-		-		-				-		-																												-
SP2:							-		-		-				-		-																												-		-
SP3:									-						-		-
SP4:																																													-		-
SP5:																																													-		-

ExUns:	15a	·	15b	·	15c	·	15d
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ABI1

13 Ensembl transcripts including schematic representations:

ENST00000376160 ENST00000359188 ENST00000376166 ENST00000346832 ENST00000376134 ENST00000376142

ENST00000355394 ENST00000376138 ENST00000376140 ENST00000376139 ENST00000376170 ENST00000376135

ENST00000376137

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ABI1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ABI1

¹ / ² / ³

6 probe-sets matching ABI1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38924_s_at²^{, 3}	U95-A	1	1.00	1.00	0.98	1.16	AF001628	1.00	0.90	0.95	1
33886_at²^{, 3}	U95-A	1	1.00	1.00	0.97	0.84	AF006516	0.80	0.70	0.75	1
209027_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF673013	0.60	1.00	0.82	1
209028_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF006516	0.80	0.70	0.75	1
209027_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209028_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CACTTTGTGT

SOURCE GeneReport for Unigene cluster: Hs.508148
Expression variation in blood from EXPOLDB for ABI1
UniProtKB/Swiss-Prot: ABI1_HUMAN, Q8IZP0
Tissue specificity: Widely expressed, with highest expression in brain

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ABI1 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ABI1¹	--	abl-interactor 1	95.46(n) 99.21(a)	607247 XM_844116.1 XP_849209.1
chimpanzee (Pan troglodytes)	ABI1¹	--	abl-interactor 1	99.61(n) 99.61(a)	450363 XM_001159512.1 XP_001159512.1
rat (Rattus norvegicus)	Abi1¹	--	abl-interactor 1	92.23(n) 98.74(a)	79249 NM_024397.1 NP_077373.1
mouse (Mus musculus)	Abi1^{1, 5}	2 (15.00 cM)⁵	abl-interactor 1^{1, 5}	92.38(n)¹ 98.34(a)¹	11308¹ NM_001077190.1¹ NP_001070658.1¹ AF420251⁵ AK034476⁵ (see all 34)
chicken (Gallus gallus)	RCJMB04_25c5¹	--	abl-interactor 1	86.61(n) 96.46(a)	420489 XM_001233768.1 XP_001233769.1

About this table Species with no ortholog for ABI1

ENSEMBL Gene Tree for ABI1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ABI1 gene

ABI2² ABI3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/731 NCBI SNPs in ABI1 are shown (see all 731 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 226)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1409128^1,2	A,C,F,H,O	27190099(-)	`CGGGCC/AGCCTA`	4	--	ng3¹		19		EA NA MN EU WA	1762
	rs10829056^1,2	A,C,F,H	27076277(+)	`GCATTT/ATGATT`	4	--	ut3¹		7		NA EU EA WA	558
	rs4749194^1,2	A,C,F,H	27191311(+)	`TGAAAG/AGAAAA`	4	--	ng3¹ trp³		7		EU EA WA NA	530
	rs2031562^1,2	A,C,F,H	27190879(-)	`taattC/Tgatcc`	4	--	ng3¹		4		EU EA WA	404
	rs2306236^1,2	C,F,H	27088083(+)	`ATCCAC/GCAGAA`	4	G/A	mis¹ ese³		13		EA EU WA	2726
	rs11015273^1,2	C,H	27094253(+)	`CTTCCA/CCTGAA`	4	S/R	mis¹		4		EU EA WA	418
	rs7086847^1,2	F,H	27077502(+)	`AAAAAA/GAATTA`	4	--	ut3¹ trp³		4		EU EA WA	404
	rs1409127^1,2	F,H	27190243(-)	`TATCAC/TCCTGT`	4	--	ng3¹ tfbs³		8		EA NA MN EU WA	654
--	rs3215811^1,2	C,F	27190043(-)	`AAAAA-/ATCCCG`	4	--	ng3¹ trp³		2		MN EA	356
--	rs9645528^1,2	A	27191945(+)	`GGAAGC/GGGGAG`	4	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for ABI1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603050

UniProtKB/Swiss-Prot: ABI1_HUMAN, Q8IZP0

A chromosomal aberration involving ABI1 is a cause of acute leukemias. Translocation

t(10;11)(p11.2;q23) with MLL. ABI1 isoform 2 was found to be present in acute leukemia MLL-ABI1

fusion transcript

2 Novoseek disease relationships for ABI1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemogenesis	63.34	1	9694699 (1)
leukemia	21.29	5	11477655 (2), 12547160 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/66 PubMed articles for ABI1 gene (see all 66 ):

Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth. (PubMed id 9010225)^{1, 2, 3, 4} Biesova Z....Wong W.T. (1997)
Identification of a candidate human spectrin Src homology 3 domain- binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton. (PubMed id 9593709)^{2, 3, 4} Ziemnicka-Kotula D.... Kotula L. (1998)
ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23). (PubMed id 9694699)^{1, 3, 4} Taki T.... Hayashi Y. (1998)
Abl interactor 1 binds to sos and inhibits epidermal growth factor- and v-Abl-induced activation of extracellular signal-regulated kinases. (PubMed id 11003655)^{1, 3, 4} Fan P.-D. and Goff S.P. (2000)
Isolation of hNap1BP which interacts with human Nap 1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease. (PubMed id 11418237)^{1, 3, 4} Yamamoto A.... Sakaki Y. (2001)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Induction of colonic epithelial cell apoptosis by p47-dependent oxidants(1). (PubMed id 12681507)^{3, 4} Gu Y.... Terada L.S. (2003)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{3, 4} Gevaert K.... Vandekerckhove J. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 10006	HGNC: 11320	AceView: ABI1	Ensembl:ENSG00000136754	euGenes: HUgn10006
ECgene: ABI1	H-InvDB: ABI1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for ABI1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ABI1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ABI1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ABI1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ABI1		Antibodies for ABI1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ABI1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ABI1)
	Antibodies (ABI1)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (SSH3BP1)
	Antibodies (SSH3BP1)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for ABI1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ABI1

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ABI1 Gene at Home site.
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ABI1 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for ABI1

Summaries
for ABI1

Genomic Location
for ABI1

Proteins
for ABI1

Protein Domains/
Families
for ABI1

Gene Function
for ABI1

Pathways & Interactions
for ABI1

Drugs & Compounds
for ABI1

Transcripts
for ABI1

Expression
for ABI1

Orthologs
for ABI1

Paralogs
for ABI1

SNPs/Variants
for ABI1

Disorders & Mutations
for ABI1

Medical News
for ABI1

Publications
for ABI1

Search for ABI1

Genome Databases showing ABI1

Other Databases showing ABI1

Specialized Databases showing ABI1

Licensable Technologies
for ABI1

Services
for ABI1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ABI1 (Gene Symbol)
ABI-1
Abi-1
AblBP4
E3B1
NAP1BP
Nap1BP
OTTHUMP00000019352
OTTHUMP00000019355
SSH3BP
SSH3BP1
e3B1
Abelson interactor 1
Abl-binding protein 4
Abl-interactor protein 1 long
Eps8 SH3 domain-binding protein
Eps8-binding protein
Nap1-binding protein
Spectrin SH3 domain-binding protein 1
abl-interactor 1
eps8 binding protein
interactor protein AblBP4
nap1 binding protein
spectrin SH3 domain binding protein 1

ABI1 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor ABI1

Summariesfor ABI1

Genomic Locationfor ABI1

Proteinsfor ABI1

Protein Domains/Familiesfor ABI1

Gene Functionfor ABI1

Pathways & Interactionsfor ABI1

Drugs & Compoundsfor ABI1

Transcriptsfor ABI1

Expression for ABI1

Orthologsfor ABI1

Paralogsfor ABI1

SNPs/Variantsfor ABI1

Disorders & Mutationsfor ABI1

Medical Newsfor ABI1

Publicationsfor ABI1

Search for ABI1

Genome Databases showing ABI1

Other Databases showing ABI1

Specialized Databases showing ABI1

Licensable Technologiesfor ABI1

Servicesfor ABI1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ABI1

Summaries
for ABI1

Genomic Location
for ABI1

Proteins
for ABI1

Protein Domains/
Families
for ABI1

Gene Function
for ABI1

Pathways & Interactions
for ABI1

Drugs & Compounds
for ABI1

Transcripts
for ABI1

Expression
for ABI1

Orthologs
for ABI1

Paralogs
for ABI1

SNPs/Variants
for ABI1

Disorders & Mutations
for ABI1

Medical News
for ABI1

Publications
for ABI1

Licensable Technologies
for ABI1

Services
for ABI1