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EPHX3 Gene

protein-coding GIFtS: 41

GC19M015199

epoxide hydrolase 3
(Previous name: abhydrolase domain containing 9 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ABHD9)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ABHD9 ^²
FLJ22408 ^¹, ²
MGC131519 ^²

Descriptions
abhydrolase domain containing 9 ^¹, ²
epoxide hydrolase 3 ^²

External Ids
HGNC: 23760¹
Entrez Gene: 79852²
UniProtKB: Q9H6B9³
Ensembl: ENSG00000105131⁷

Search outside databases for aliases for EPHX3 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.12 Ensembl cytogenetic band: 19p13.12 HGNC cytogenetic band: 19p13.13

EPHX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M015199: (about GC identifiers)

Start:	15,198,730 bp from pter
End:	15,204,231 bp from pter
Size:	5,502 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_011295.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ABHD9_HUMAN, Q9H6B9 (See protein sequence)

Recommended Name: Abhydrolase domain-containing protein 9 precursor

Size: 360 amino acids; 40909 Da

REFSEQ proteins (2 alternative transcripts):

NP_001136358.1 NP_079070.1

ENSEMBL proteins:

ENSP00000221730

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ABHD9)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--

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Antibodies for EPHX3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ABHD9), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for EPHX3

Assays for EPHX3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9H6B9

ProtoNet protein and cluster: Q9H6B9

3 Blocks protein families:

IPB000073 Alpha/beta hydrolase fold

IPB000639 Epoxide hydrolase signature

IPB003089 Alpha/beta hydrolase fold signature

UniProtKB/Swiss-Prot: ABHD9_HUMAN, Q9H6B9

Similarity: Belongs to the AB hydrolase superfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EPHX3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_024794

Applied Biosystems Silencer® siRNAs for EPHX3

Sigma-Aldrich siRNA and siRNA Panels for EPHX3

Sigma-Aldrich shRNA for EPHX3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001142886
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001142886
untagged cDNA clones in CMV expression vector (see all 2): NM_001142886

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001142886

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016787	hydrolase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Interacting protein for EPHX3 (ENSP00000221730³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NPBWR1	ENSP00000330284³	STRING (score=.702)

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for EPHX3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EPHX3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_024794

Sigma-Aldrich siRNA and siRNA Panels for EPHX3

Sigma-Aldrich shRNA for EPHX3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001142886 NM_024794

REFSEQ mRNAs for EPHX3 gene (2 alternative transcripts):

NM_001142886.1 NM_024794.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001142886 NM_024794

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001142886
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001142886
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001142886

Additional cDNA sequence:

AK026061.1 BC115002.1 BC132958.1 BC132960.1 CR619338.1

5 DOTS entries:

DT.75100656 DT.100777024 DT.100015978 DT.102822974 DT.91913187

24/35 AceView cDNA sequences (see all 35 ):

NM_024794 BG740598 BE539695 AK026061 CR619338 BX284101 BX359857 AW139205

CD632296 BF513501 CD632297 AI341152 AI656299 BF510541 CD632298 BF516044

BX390515 AW451646 BQ028067 BX371829 AA160909 AI570023 BQ027495 BX359856

Unigene Cluster for EPHX3:

Epoxide hydrolase 3

Hs.156457 [show with all ESTs]

Unigene Representative Sequence: AK026061

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000221730

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

EPHX3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for EPHX3

¹ / ²

3 probe-sets matching EPHX3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
83638_at²	U95-E	1	1.00	1.00	1.00	1.00	--	--	--	--	--
220013_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
220013_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks EPHX3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTGTGTAAC

SOURCE GeneReport for Unigene cluster: Hs.156457

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for EPHX3 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ABHD9¹	--	abhydrolase domain containing 9	99.44(n) 99.72(a)	455793 XM_001172161.1 XP_001172161.1
cow (Bos taurus)	ABHD9¹	--	abhydrolase domain containing 9	86.3(n) 89.72(a)	617882 XM_870212.2 XP_875305.1
rat (Rattus norvegicus)	Abhd9¹	--	abhydrolase domain containing 9	80.07(n) 80.73(a)	366836 XM_345799.2 XP_345800.1
mouse (Mus musculus)	Ephx3⁵ Abhd9¹	17⁵	epoxide hydrolase 3⁵ abhydrolase domain containing 9¹	80.78(n)¹ 83.29(a)¹	71932¹ NM_001033163.2¹ NP_001028335.1¹ AK010021⁵ AK132483⁵ (see all 6)
soybean (Glycine max)	44488725²	--	--	78.85(n)	44488725

About this table Species with no ortholog for EPHX3

ENSEMBL Gene Tree for EPHX3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for EPHX3 gene

EPHX2² ENSG00000172031²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/18 NCBI SNPs in EPHX3 are shown (see all 18 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 18)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs757291^1,2	A,C,F,H	15198785(+)	`TTAAGT/CTGAAG`	2	--	ut3¹ ese³		5		MN EU EA WA	596
	rs11668059^1,2	H	15204211(+)	`CTCACC/TTGAGT`	1	--	ut5¹ ese³		4		EU EA WA	414
	rs3746204^1,2	H	15199370(-)	`GCAGCC/TGCTTT`	2	R/C	mis¹ ese³		4		EU EA WA	418
	rs34957770^1,2	--	15204757(+)	`CTTCAC/GTTAAG`	2	--	ng3¹ ut5¹		0	--	--	--	--
--	rs34495791^1,2	--	15203991(+)	`CGGCG-/CCCAGC`	2	A/G	fra¹		0	--	--	--	--
--	rs34503575^1,2	--	15204972(+)	`GGGGT-/GGGGGT`	1	--	ng3¹		0	--	--	--	--
--	rs57900997^1,2	--	15198233(+)	`CCAGGA/CTGGTC`	1	--	ng5¹		0	--	--	--	--
--	rs73506397^1,2	--	15205350(+)	`CAAGCC/GACAGG`	1	--	ng3¹		0	--	--	--	--
--	rs59451890^1,2	--	15198254(+)	`ACCTC-/AAGTGAT`	1	--	ng5¹		0	--	--	--	--
--	rs34840941^1,2	--	15206031(+)	`TGAAAC/TTCGAG`	1	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for EPHX3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for EPHX3 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Discovery and validation of 3 novel DNA methylation markers of prostate cancer prognosis. (PubMed id 17437806)³ Cottrell S....Weiss G. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. (PubMed id 15203218)³ Fu G.K....Stuve L.L. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 79852	HGNC: 23760	AceView: ABHD9	Ensembl:ENSG00000105131	euGenes: HUgn79852
ECgene: EPHX3	H-InvDB: EPHX3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for EPHX3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for EPHX3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for EPHX3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for EPHX3		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for EPHX3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
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	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (ABHD9)
	Antibodies (ABHD9)

Search OriGene for EPHX3

Search Tocris compounds for EPHX3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for EPHX3

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EPHX3 Gene

protein-coding GIFtS: 41

Aliases &
Descriptions
for EPHX3

Summaries
for EPHX3

Genomic Location
for EPHX3

Proteins
for EPHX3

Protein Domains/
Families
for EPHX3

Gene Function
for EPHX3

Pathways & Interactions
for EPHX3

Drugs & Compounds
for EPHX3

Transcripts
for EPHX3

Expression
for EPHX3

Orthologs
for EPHX3

Paralogs
for EPHX3

SNPs/Variants
for EPHX3

Disorders & Mutations
for EPHX3

Medical News
for EPHX3

Publications
for EPHX3

Search for EPHX3

Genome Databases showing EPHX3

Other Databases showing EPHX3

Specialized Databases showing EPHX3

Licensable Technologies
for EPHX3

Services
for EPHX3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

EPHX3 Gene

protein-coding GIFtS: 41

Aliases & Descriptionsfor EPHX3

Summariesfor EPHX3

Genomic Locationfor EPHX3

Proteinsfor EPHX3

Protein Domains/Familiesfor EPHX3

Gene Functionfor EPHX3

Pathways & Interactionsfor EPHX3

Drugs & Compoundsfor EPHX3

Transcriptsfor EPHX3

Expression for EPHX3

Orthologsfor EPHX3

Paralogsfor EPHX3

SNPs/Variantsfor EPHX3

Disorders & Mutationsfor EPHX3

Medical Newsfor EPHX3

Publicationsfor EPHX3

Search for EPHX3

Genome Databases showing EPHX3

Other Databases showing EPHX3

Specialized Databases showing EPHX3

Licensable Technologiesfor EPHX3

Servicesfor EPHX3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for EPHX3

Summaries
for EPHX3

Genomic Location
for EPHX3

Proteins
for EPHX3

Protein Domains/
Families
for EPHX3

Gene Function
for EPHX3

Pathways & Interactions
for EPHX3

Drugs & Compounds
for EPHX3

Transcripts
for EPHX3

Expression
for EPHX3

Orthologs
for EPHX3

Paralogs
for EPHX3

SNPs/Variants
for EPHX3

Disorders & Mutations
for EPHX3

Medical News
for EPHX3

Publications
for EPHX3

Licensable Technologies
for EPHX3

Services
for EPHX3