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Aliases for ABHD8 Gene

Aliases for ABHD8 Gene

  • Abhydrolase Domain Containing 8 2 3
  • EC 3.-.-.- 4

External Ids for ABHD8 Gene

Previous GeneCards Identifiers for ABHD8 Gene

  • GC19M017402
  • GC19M016969

Summaries for ABHD8 Gene

Entrez Gene Summary for ABHD8 Gene

  • This gene is upstream of, and in a head-to-head orientation with the gene for the mitochondrial ribosomal protein L34. The predicted protein contains alpha/beta hydrolase fold and secretory lipase domains. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABHD8 Gene

ABHD8 (Abhydrolase Domain Containing 8) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD8 Gene

Genomics for ABHD8 Gene

Regulatory Elements for ABHD8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ABHD8 Gene

Start:
17,292,131 bp from pter
End:
17,310,236 bp from pter
Size:
18,106 bases
Orientation:
Minus strand

Genomic View for ABHD8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABHD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD8 Gene

Proteins for ABHD8 Gene

  • Protein details for ABHD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96I13-ABHD8_HUMAN
    Recommended name:
    Abhydrolase domain-containing protein 8
    Protein Accession:
    Q96I13
    Secondary Accessions:
    • Q9HAE9

    Protein attributes for ABHD8 Gene

    Size:
    439 amino acids
    Molecular mass:
    47331 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ABHD8 Gene

Proteomics data for ABHD8 Gene at MOPED

Post-translational modifications for ABHD8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ABHD8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ABHD8

No data available for DME Specific Peptides for ABHD8 Gene

Domains for ABHD8 Gene

Gene Families for ABHD8 Gene

HGNC:
  • ABHD :Abhydrolase domain containing

Graphical View of Domain Structure for InterPro Entry

Q96I13

UniProtKB/Swiss-Prot:

ABHD8_HUMAN :
  • Q96I13
Family:
  • Belongs to the AB hydrolase superfamily.
genes like me logo Genes that share domains with ABHD8: view

Function for ABHD8 Gene

Enzyme Numbers (IUBMB) for ABHD8 Gene

Gene Ontology (GO) - Molecular Function for ABHD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ABHD8: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABHD8

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ABHD8 Gene

Localization for ABHD8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABHD8 Gene COMPARTMENTS Subcellular localization image for ABHD8 gene
Compartment Confidence
cytosol 2
plasma membrane 2
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ABHD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with ABHD8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ABHD8 Gene

Pathways for ABHD8 Gene

SuperPathways for ABHD8 Gene

No Data Available

Interacting Proteins for ABHD8 Gene

Gene Ontology (GO) - Biological Process for ABHD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with ABHD8: view

No data available for Pathways by source for ABHD8 Gene

Transcripts for ABHD8 Gene

mRNA/cDNA for ABHD8 Gene

Unigene Clusters for ABHD8 Gene

Abhydrolase domain containing 8:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABHD8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD8 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2:
SP3: -

Relevant External Links for ABHD8 Gene

GeneLoc Exon Structure for
ABHD8
ECgene alternative splicing isoforms for
ABHD8

Expression for ABHD8 Gene

mRNA expression in normal human tissues for ABHD8 Gene

mRNA differential expression in normal tissues according to GTEx for ABHD8 Gene

This gene is overexpressed in Brain - Cortex (4.3).

Protein differential expression in normal tissues for ABHD8 Gene

This gene is overexpressed in Breast (50.8), Neutrophil (9.4), and Pancreatic juice (8.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ABHD8 Gene

SOURCE GeneReport for Unigene cluster for ABHD8 Gene Hs.515664

genes like me logo Genes that share expressions with ABHD8: view

Expression partners for ABHD8 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ABHD8 Gene

Orthologs for ABHD8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ABHD8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ABHD8 35
  • 89.23 (n)
  • 96.41 (a)
ABHD8 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABHD8 35
  • 87.86 (n)
  • 95.36 (a)
ABHD8 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abhd8 35
  • 82.11 (n)
  • 91.18 (a)
Abhd8 16
Abhd8 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ABHD8 35
  • 99.47 (n)
  • 99.77 (a)
ABHD8 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abhd8 35
  • 81.78 (n)
  • 90.44 (a)
oppossum
(Monodelphis domestica)
Mammalia ABHD8 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABHD8 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves ABHD8 35
  • 76.4 (n)
  • 76.89 (a)
ABHD8 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd8 35
  • 67.07 (n)
  • 73.3 (a)
Str.5563 35
zebrafish
(Danio rerio)
Actinopterygii abhd8a 35
  • 67.63 (n)
  • 71.39 (a)
abhd8a 36
  • 65 (a)
OneToMany
BX255969.1 36
  • 57 (a)
OneToMany
Species with no ortholog for ABHD8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABHD8 Gene

ENSEMBL:
Gene Tree for ABHD8 (if available)
TreeFam:
Gene Tree for ABHD8 (if available)

Paralogs for ABHD8 Gene

No data available for Paralogs for ABHD8 Gene

Variants for ABHD8 Gene

Sequence variations from dbSNP and Humsavar for ABHD8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs3745186 -- 17,301,409(+) GTCCC(C/T)CTGGG missense, reference
rs3745187 -- 17,303,317(+) GGCGC(C/T)GTTTA utr-variant-5-prime
rs4808616 -- 17,292,224(+) AATAG(A/C)TCCCA utr-variant-3-prime
rs4808617 -- 17,293,560(+) cacta(G/T)atgcc intron-variant
rs4808620 -- 17,296,279(+) GAACT(C/T)CTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABHD8 Gene

Variant ID Type Subtype PubMed ID
dgv3758n71 CNV Loss 21882294
nsv911182 CNV Loss 21882294
nsv470129 CNV Loss 18288195
nsv911185 CNV Loss 21882294
nsv911186 CNV Gain 21882294
dgv3759n71 CNV Loss 21882294
dgv3760n71 CNV Loss 21882294
nsv911198 CNV Loss 21882294
nsv515965 CNV Loss 19592680
nsv911200 CNV Loss 21882294
esv1009781 CNV Deletion 20482838

Relevant External Links for ABHD8 Gene

HapMap Linkage Disequilibrium report
ABHD8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABHD8 Gene

Disorders for ABHD8 Gene

No disorders were found for ABHD8 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ABHD8 Gene

Publications for ABHD8 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. (PMID: 18570454) Kang D. … Moon M.H. (J. Proteome Res. 2008) 3

Products for ABHD8 Gene

Sources for ABHD8 Gene

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