Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ABHD8 Gene

Aliases for ABHD8 Gene

  • Abhydrolase Domain Containing 8 2 3 5
  • Alpha/Beta Hydrolase Domain-Containing Protein 8 4
  • Abhydrolase Domain-Containing Protein 8 4
  • EC 3.-.-.- 4

External Ids for ABHD8 Gene

Previous GeneCards Identifiers for ABHD8 Gene

  • GC19M017402
  • GC19M016969

Summaries for ABHD8 Gene

Entrez Gene Summary for ABHD8 Gene

  • This gene is upstream of, and in a head-to-head orientation with the gene for the mitochondrial ribosomal protein L34. The predicted protein contains alpha/beta hydrolase fold and secretory lipase domains. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABHD8 Gene

ABHD8 (Abhydrolase Domain Containing 8) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD8 Gene

Genomics for ABHD8 Gene

Regulatory Elements for ABHD8 Gene

Enhancers for ABHD8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ABHD8 on UCSC Golden Path with GeneCards custom track

Promoters for ABHD8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ABHD8 on UCSC Golden Path with GeneCards custom track

Genomic Location for ABHD8 Gene

17,292,131 bp from pter
17,310,236 bp from pter
18,106 bases
Minus strand

Genomic View for ABHD8 Gene

Genes around ABHD8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABHD8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABHD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD8 Gene

Proteins for ABHD8 Gene

  • Protein details for ABHD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein ABHD8
    Protein Accession:
    Secondary Accessions:
    • Q9HAE9

    Protein attributes for ABHD8 Gene

    439 amino acids
    Molecular mass:
    47331 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ABHD8 Gene

Proteomics data for ABHD8 Gene at MOPED

Post-translational modifications for ABHD8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ABHD8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ABHD8
  • Santa Cruz Biotechnology (SCBT) Antibodies for ABHD8

No data available for DME Specific Peptides for ABHD8 Gene

Domains & Families for ABHD8 Gene

Gene Families for ABHD8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AB hydrolase superfamily.
  • Belongs to the AB hydrolase superfamily.
genes like me logo Genes that share domains with ABHD8: view

Function for ABHD8 Gene

Enzyme Numbers (IUBMB) for ABHD8 Gene

genes like me logo Genes that share phenotypes with ABHD8: view

Animal Model Products

miRNA for ABHD8 Gene

miRTarBase miRNAs that target ABHD8

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABHD8 Gene

Localization for ABHD8 Gene

Subcellular locations from

Jensen Localization Image for ABHD8 Gene COMPARTMENTS Subcellular localization image for ABHD8 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 2
plasma membrane 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ABHD8 Gene

Pathways & Interactions for ABHD8 Gene

SuperPathways for ABHD8 Gene

No Data Available

Interacting Proteins for ABHD8 Gene

Gene Ontology (GO) - Biological Process for ABHD8 Gene


No data available for Pathways by source and SIGNOR curated interactions for ABHD8 Gene

Drugs & Compounds for ABHD8 Gene

No Compound Related Data Available

Transcripts for ABHD8 Gene

mRNA/cDNA for ABHD8 Gene

Unigene Clusters for ABHD8 Gene

Abhydrolase domain containing 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD8 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP3: -

Relevant External Links for ABHD8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ABHD8 Gene

mRNA expression in normal human tissues for ABHD8 Gene

mRNA differential expression in normal tissues according to GTEx for ABHD8 Gene

This gene is overexpressed in Brain - Cortex (x4.3).

Protein differential expression in normal tissues from HIPED for ABHD8 Gene

This gene is overexpressed in Breast (50.8), Neutrophil (9.4), and Pancreatic juice (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ABHD8 Gene

SOURCE GeneReport for Unigene cluster for ABHD8 Gene Hs.515664

genes like me logo Genes that share expression patterns with ABHD8: view

Protein tissue co-expression partners for ABHD8 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ABHD8 Gene

Orthologs for ABHD8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ABHD8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ABHD8 35
  • 89.23 (n)
  • 96.41 (a)
ABHD8 36
  • 97 (a)
(Canis familiaris)
Mammalia ABHD8 35
  • 87.86 (n)
  • 95.36 (a)
ABHD8 36
  • 97 (a)
(Mus musculus)
Mammalia Abhd8 35
  • 82.11 (n)
  • 91.18 (a)
Abhd8 16
Abhd8 36
  • 88 (a)
(Pan troglodytes)
Mammalia ABHD8 35
  • 99.47 (n)
  • 99.77 (a)
ABHD8 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Abhd8 35
  • 81.78 (n)
  • 90.44 (a)
(Monodelphis domestica)
Mammalia ABHD8 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia ABHD8 36
  • 79 (a)
(Gallus gallus)
Aves ABHD8 35
  • 76.4 (n)
  • 76.89 (a)
ABHD8 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd8 35
  • 67.07 (n)
  • 73.3 (a)
Str.5563 35
(Danio rerio)
Actinopterygii abhd8a 35
  • 67.63 (n)
  • 71.39 (a)
abhd8a 36
  • 65 (a)
BX255969.1 36
  • 57 (a)
Species with no ortholog for ABHD8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABHD8 Gene

Gene Tree for ABHD8 (if available)
Gene Tree for ABHD8 (if available)

Paralogs for ABHD8 Gene

No data available for Paralogs for ABHD8 Gene

Variants for ABHD8 Gene

Structural Variations from Database of Genomic Variants (DGV) for ABHD8 Gene

Variant ID Type Subtype PubMed ID
dgv3758n71 CNV Loss 21882294
nsv911182 CNV Loss 21882294
nsv470129 CNV Loss 18288195
nsv911185 CNV Loss 21882294
nsv911186 CNV Gain 21882294
dgv3759n71 CNV Loss 21882294
dgv3760n71 CNV Loss 21882294
nsv911198 CNV Loss 21882294
nsv515965 CNV Loss 19592680
nsv911200 CNV Loss 21882294
esv1009781 CNV Deletion 20482838

Variation tolerance for ABHD8 Gene

Residual Variation Intolerance Score: 20.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.73; 73.25% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for ABHD8 Gene

Disorders for ABHD8 Gene

Relevant External Links for ABHD8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ABHD8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABHD8 Gene

Publications for ABHD8 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. (PMID: 20852631) Antoniou A.C. … Couch F.J. (Nat. Genet. 2010) 3
  4. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. (PMID: 18570454) Kang D. … Moon M.H. (J. Proteome Res. 2008) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ABHD8 Gene

Sources for ABHD8 Gene