ABHD8 Gene
protein-coding GIFtS: 43
GCID: GC19M017402
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abhydrolase domain containing 8
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Aliases
for ABHD8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Abhydrolase Domain Containing 81 2 | | FLJ117431 | | MGC142801 | | MGC25121 | | Abhydrolase Domain-Containing Protein 82 | | EC 3.-.-.-3 |
Export aliases for ABHD8 gene to outside databasesPrevious GC identifers: GC19M017263 GC19M016969 |
Summaries
for ABHD8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ABHD8:
This gene is upstream of, and in a head-to-head orientation with the gene for the mitochondrial ribosomal protein L34.The predicted protein contains alpha/beta hydrolase fold and secretory lipase domains. (provided by RefSeq, Jul 2008)
|
Genomic Views
for ABHD8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ABHD8 gene promoter:
HFH-3 C/EBPbeta AP-1 MAZR p53 POU6F1 (c2) E47 GATA-1 FOXI1 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for ABHD8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABHD8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.11 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.12ABHD8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M017402: view genomic region
(about GC identifiers)
Start:
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17,402,940 bp from pter |
End:
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17,414,282 bp from pter |
Size:
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11,343 bases |
Orientation:
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minus strand |
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Proteins
for ABHD8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ABHD8_HUMAN, Q96I13 (See
protein sequence)Recommended Name: Abhydrolase domain-containing protein 8 Size: 439 amino acids; 47331 Da
Secondary accessions: Q9HAE9Explore the universe of human proteins at neXtProt for ABHD8: NX_Q96I13
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96I13
ABHD8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_078803.4
ENSEMBL proteins: ENSP00000247706
Human Recombinant Protein Products for ABHD8:
ABHD8 Antibody Products:
Assay Products for ABHD8: |
Protein
Domains /
Families
for ABHD8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ABHD8 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96I13ProtoNet protein and cluster: Q96I13 3 Blocks protein families: IPB000073 Alpha/beta hydrolase fold IPB000639 Epoxide hydrolase signature IPB003089 Alpha/beta hydrolase fold signature
UniProtKB/Swiss-Prot: ABHD8_HUMAN, Q96I13Similarity: Belongs to the AB hydrolase superfamily |
Function
for ABHD8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Number (IUBMB): EC 3.-.-.-1
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016787 | hydrolase activity |
IEA | -- |
ABHD8 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ABHD8 (NM_024527) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ABHD8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABHD8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABHD8 |
|
Pathways & Interactions
for ABHD8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ABHD8
|
Drugs & Compounds
for ABHD8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ABHD8
Search CenterWatch for drugs/clinical trials and news about ABHD8
|
Transcripts
for ABHD8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ABHD8 gene: NM_024527.4 Unigene Cluster for ABHD8: Abhydrolase domain containing 8 Hs.515664 [show with all ESTs]Unigene Representative Sequence: NM_0245271 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000247706(uc002ngb.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ABHD8 (NM_024527) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ABHD8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABHD8 |
Additional cDNA sequence: AK021805.1 AK225140.1 AK225340.1 AK298251.1 AK315366.1 BC007895.2 BC011536.2 BC020173.1 BC039087.1 EU285559.1 7 DOTS entries: DT.304564 DT.100775366 DT.121465020 DT.91922602 DT.95078030 DT.91725794 DT.99997985 24/96 AceView cDNA sequences (see all 96): BQ636471 BC039087 AW190173 BC011536 BM054879 BI966157 CR603220 AA325517 BU149876 CR618792 BI821859 CF529063 CF529869 AI125846 BM690291 BC007895 BE514016 CK299694 BM729370 BI966228 BX332216 BM927155 BE778238 BI829436
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ABHD8 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 |
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| SP1: | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ABHD8
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Expression
for ABHD8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ABHD8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGATGCTGG
About this image
See ABHD8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ABHD8
SOURCE GeneReport for Unigene cluster: Hs.515664
SABiosciences Custom PCR Arrays for ABHD8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABHD8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ABHD8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABHD8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABHD8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABHD8 |
Orthologs
for ABHD8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ABHD8 gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for ABHD8 (if available)
TreeFam Gene Tree for ABHD8 (if available) |
Paralogs
for ABHD8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ABHD8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ABHD8 (17402940 - 17414282 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ABHD8
2 CNVs: 50091 30071 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABHD8 |
|
Disorders
/ Diseases
for ABHD8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ABHD8 for disorders About GeneDecksing
1  disease for ABHD8: About MalaCardsbreast cancer
Export disorders for ABHD8 gene to outside databases
|
Publications
for ABHD8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ABHD8 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ABHD8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A locus on 19p13 modifies risk of breast cancer in BR CA1 mutation carriers and is associated with hormone receptor-negative breast c ancer in the general population. (PubMed id 20852631)1 Antoniou A.C....Couch F.J. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
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External Searches for ABHD8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ABHD8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ABHD8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ABHD8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ABHD8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ABHD8 gene:
Search GeneIP for patents involving ABHD8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ABHD8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ABHD8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABHD8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABHD8 | | | OriGene Protein Over-expression Lysate for ABHD8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ABHD8 | | OriGene 3'-UTR Clone for ABHD8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ABHD8 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ABHD8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABHD8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABHD8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABHD8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABHD8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABHD8 |
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 | | | ABHD8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABHD8 |
|  |  |  |  | | | | ThermoFisher Antibodies for ABHD8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABHD8 |
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