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ABHD6 Gene

protein-coding   GIFtS: 50
GCID: GC03P058198

Abhydrolase Domain Containing 6

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Abhydrolase Domain Containing 61 2
Abhydrolase Domain-Containing Protein 62 3
2-Arachidonoylglycerol Hydrolase2 3
EC 3.1.1.233 8
Lipase Protein2
Monoacylglycerol Lipase ABHD62

External Ids:    HGNC: 213981   Entrez Gene: 574062   Ensembl: ENSG000001636867   UniProtKB: Q9BV233   

Export aliases for ABHD6 gene to outside databases

Previous GC identifers: GC03P058078 GC03P058180


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ABHD6 Gene:
ABHD6 (abhydrolase domain containing 6) is a protein-coding gene. GO annotations related to this gene include acylglycerol lipase activity.

UniProtKB/Swiss-Prot: ABHD6_HUMAN, Q9BV23
Function: Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid
signaling pathways (By similarity)

summary for ABHD6 Gene:
ABHD6 encodes a serine hydrolase enzyme known as alpha/beta-hydrolase domain 6. This enzyme catalyzes the
hydrolysis of 2-arachidonylglycerol.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ABHD6 gene promoter:
         c-Fos   AP-1   AML1a   Bach2   JunB   FosB   Fra-1   HNF-4alpha2   JunD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidABHD6 promoter sequence
   Search Chromatin IP Primers for ABHD6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ABHD6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.3   Ensembl cytogenetic band:  3p14.3   HGNC cytogenetic band: 3p21.2

ABHD6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABHD6 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P058198:  view genomic region     (about GC identifiers)

Start:
58,223,233 bp from pter      End:
58,281,420 bp from pter
Size:
58,188 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ABHD6_HUMAN, Q9BV23 (See protein sequence)
Recommended Name: Monoacylglycerol lipase ABHD6  
Size: 337 amino acids; 38331 Da
Secondary accessions: B2R7Y9 Q6ZMF7

Explore the universe of human proteins at neXtProt for ABHD6: NX_Q9BV23

Explore proteomics data for ABHD6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys223
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ABHD6 (Q9BV23) (see all 7)
     IYYWYWRR  GQVKRIHQFVE  LQGLVDVRIPHN  LVCPAGLQYSTDN 


    See ABHD6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065727.4  
    ENSEMBL proteins: 
     ENSP00000420315   ENSP00000295962   ENSP00000418209   ENSP00000420408   ENSP00000418934  

    ABHD6 Human Recombinant Protein Products:

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    OriGene Purified Protein for ABHD6
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    Novus Biologicals ABHD6 Protein
    Novus Biologicals ABHD6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ABHD6

     
    Search eBioscience for Proteins for ABHD6 

    ABHD6 Antibody Products:

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    Abcam antibodies for ABHD6
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    LSBio Antibodies in human, mouse, rat for ABHD6

    ABHD6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for ABHD6
    Cloud-Clone Corp. CLIAs for ABHD6
    Search eBioscience for ELISAs for ABHD6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ABHD: Abhydrolase domain containing

    2 InterPro protein domains:
     IPR000073 AB_hydrolase_1
     IPR000639 Epox_hydrolase-like

    Graphical View of Domain Structure for InterPro Entry Q9BV23

    ProtoNet protein and cluster: Q9BV23

    3 Blocks protein domains:
    IPB000073 Alpha/beta hydrolase fold
    IPB000639 Epoxide hydrolase signature
    IPB003089 Alpha/beta hydrolase fold signature


    UniProtKB/Swiss-Prot: ABHD6_HUMAN, Q9BV23
    Similarity: Belongs to the AB hydrolase superfamily


    Find genes that share domains with ABHD6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ABHD6_HUMAN, Q9BV23
    Function: Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid
    signaling pathways (By similarity)
    Catalytic activity: Hydrolyzes glycerol monoesters of long-chain fatty acids

         Enzyme Number (IUBMB): EC 3.1.1.231 2

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0047372acylglycerol lipase activity IEA--
         
    Find genes that share ontologies with ABHD6           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ABHD6:
     Decreased viability of wild-ty 

         1 MGI phenotypic allele for Abhd6 (no phenotypes)

    Find genes that share phenotypes with ABHD6           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ABHD6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ABHD6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ABHD6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ABHD6

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ABHD6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ABHD6 (see all 11):
    hsa-miR-4324 hsa-miR-1266 hsa-miR-125a-5p hsa-miR-137 hsa-miR-486-3p hsa-miR-432 hsa-miR-4260 hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidABHD6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ABHD6
    Predesigned siRNA for gene silencing in human, mouse, rat ABHD6

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ABHD6 (NM_020676)
    Sino Biological Human cDNA Clone for ABHD6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABHD6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABHD6

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABHD6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ABHD6_HUMAN, Q9BV23: Membrane; Single-pass type II membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    mitochondrion2
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0032281alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex IEA--

    Find genes that share ontologies with ABHD6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ABHD6 About    
    See pathways by source

    SuperPathContained pathways About
    1Circadian entrainment
    Retrograde endocannabinoid signaling0.51
    2triacylglycerol degradation
    triacylglycerol degradation


    Find genes that share SuperPaths with ABHD6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ABHD6
        triacylglycerol degradation



    1 Kegg Pathway  (Kegg details for ABHD6):
        Retrograde endocannabinoid signaling

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ABHD6
    Interactions:

        Search GeneGlobe Interaction Network for ABHD6

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ABHD6 (ENSP000002959624) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    CKMT2ENSP000002540354STRING: ENSP00000254035
    PCGF2ENSP000003540334STRING: ENSP00000354033
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030336negative regulation of cell migration IEA--
    GO:0060292long term synaptic depression IEA--
    GO:2000124regulation of endocannabinoid signaling pathway IEA--

    Find genes that share ontologies with ABHD6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ABHD6 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (Z)-PugnacO-GlcNAcase and beta-hexosaminidase inhibitor[132489-69-1]
    Thiamet GPotent O-GlcNAcase inhibitor[1009816-48-1]
    JW 480Potent and selective inhibitor of serine hydrolase KIAA1363 (AADACL1)[1354359-53-7]
    FlurofamideUrease inhibitor[70788-28-2]
    WWL 70Potent ABHD6 inhibitor[947669-91-2]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ABHD6 gene: 
    NM_020676.5  

    Unigene Cluster for ABHD6:

    Abhydrolase domain containing 6
    Hs.476454  [show with all ESTs]
    Unigene Representative Sequence: AK225942
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000478253(uc003djt.4) ENST00000295962(uc003djs.4) ENST00000475982
    ENST00000463756 ENST00000485900 ENST00000470440 ENST00000480457
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ABHD6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ABHD6 (see all 11):
    hsa-miR-4324 hsa-miR-1266 hsa-miR-125a-5p hsa-miR-137 hsa-miR-486-3p hsa-miR-432 hsa-miR-4260 hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidABHD6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ABHD6
    Predesigned siRNA for gene silencing in human, mouse, rat ABHD6
    Clone
    Products:
         
    OriGene clones in human, mouse for ABHD6 (see all 6)
    OriGene ORF clones in mouse, rat for ABHD6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ABHD6 (NM_020676)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABHD6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABHD6
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ABHD6
    OriGene qSTAR qPCR primer pairs in human, mouse for ABHD6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ABHD6
      QuantiTect SYBR Green Assays in human, mouse, rat ABHD6
      QuantiFast Probe-based Assays in human, mouse, rat ABHD6

    Additional mRNA sequence: 

    AF225418.1 AK055828.1 AK092841.1 AK122983.1 AK172797.1 AK225942.1 AK313168.1 BC001698.2 

    10 DOTS entries:

    DT.100022211  DT.100804023  DT.100777846  DT.447939  DT.100706283  DT.120887596  DT.91665716  DT.92428430 
    DT.95275499  DT.75130741 

    Selected AceView cDNA sequences (see all 168):

    AI368377 CR589982 AK055828 BF939691 BI761932 AI077708 AA669791 CN484322 
    AI086303 BE218690 AA826493 AA554932 AA993799 BI517499 CB306972 AA889734 
    BC001698 AI016045 BE858812 BM693999 AA704681 BI668176 AI086937 BU626183 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ABHD6    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                                                                          
    SP2:                    -                                                                     
    SP3:                                                                                          
    SP4:                    -                                                                     


    ECgene alternative splicing isoforms for ABHD6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ABHD6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ABHD6 Expression
    About this image

    ABHD6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ABHD6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.476454
        Custom PCR Arrays for ABHD6
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABHD6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ABHD6 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Abhd61 , 5 abhydrolase domain containing 61, 5 90.12(n)1
    94.01(a)1
      14 (4.69 cM)5
    660821  NM_025341.31  NP_079617.21 
     80029025 
    chicken
    (Gallus gallus)
    Aves ABHD61 abhydrolase domain containing 6 74.93(n)
    80.3(a)
      416009  XM_414352.4  XP_414352.1 
    lizard
    (Anolis carolinensis)
    Reptilia ABHD66
    abhydrolase domain containing 6
    69(a)
    1 ↔ 1
    2(163775669-163796181)
    African clawed frog
    (Xenopus laevis)
    Amphibia abhd6-prov2 abhydrolase domain containing 6 75.58(n)    BC054984.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.139802 Transcribed sequences 74.54(n)    BM182875.1 


    ENSEMBL Gene Tree for ABHD6 (if available)
    TreeFam Gene Tree for ABHD6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ABHD6 (see all 1343)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1500231341,2
    C--58221278(+) ACCTAA/GGTGGG 1 -- us2k10--------
    rs1827308631,2
    --58221290(+) TTCCTC/TAGTGA 1 -- us2k10--------
    rs1453435351,2
    --58221296(+) AGTGAC/TAGCAC 1 -- us2k10--------
    rs1165213141,2
    C--58221371(+) CACTGC/TAAAAC 1 -- us2k10--------
    rs760488021,2
    C,F--58221409(+) AGCCAT/GCCAGT 1 -- us2k11Minor allele frequency- G:0.03NA 120
    rs730779571,2
    F--58221529(+) GGAGAC/AGCCCA 1 -- us2k11Minor allele frequency- A:0.08NA 120
    rs790503401,2
    F--58221672(+) TCTAGG/ACTGGG 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs76402591,2
    C,F,A,H--58221822(+) TTGTGC/TTATCT 1 -- us2k137Minor allele frequency- T:0.47NS EA NA WA CSA 3563
    rs64459601,2
    C,F,A,H--58221932(+) CCGCTC/GTTTGG 1 -- us2k126Minor allele frequency- G:0.15NS EA NA WA CSA 2500
    rs117146751,2
    H--58221973(+) ATTCCC/GTGAAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ABHD6 (58223233 - 58281420 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ABHD6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660248CNV Deletion23128226
    nsv834703CNV Gain17160897
    nsv528147CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ABHD6
    DNA2.0 Custom Variant and Variant Library Synthesis for ABHD6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ABHD6 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with ABHD6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. An unannotated alpha/beta hydrolase superfamily member, ABHD6 differentially expressed among cancer cell lines. (PubMed id 18360779)1, 9 Li F....Ji C. (Mol. Biol. Rep. 2009)
    4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    5. Developmental trajectory of the endocannabinoid system in human dorsolateral prefrontal cortex. (PubMed id 22827915)1 Long L.E....Weickert C.S. (BMC Neurosci 2012)
    6. Biochemical and pharmacological characterization of human I+/I^-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12). (PubMed id 22969151)1 Navia-Paldanius D....Laitinen J.T. (J. Lipid Res. 2012)
    7. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. High expression of the evolutionarily conserved alpha/beta hydrolase domain containing 6 (ABHD6) in Ewing tumors. (PubMed id 19793082)1 Max D....Staege M.S. (Cancer Sci. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57406 HGNC: 21398 AceView: ABHD6 Ensembl:ENSG00000163686 euGenes: HUgn57406
    ECgene: ABHD6 Kegg: 57406 H-InvDB: ABHD6

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ABHD6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ABHD6 gene:
    Search GeneIP for patents involving ABHD6

    GeneCards and IP:
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