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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ABHD6 Gene

protein-coding GIFtS: 48
GCID: GC03P058198

abhydrolase domain containing 6

Explore 26 diseases affiliated with
ABHD6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Abhydrolase Domain Containing 6¹ ²
Abhydrolase Domain-Containing Protein 6² ³
2-Arachidonoylglycerol Hydrolase² ³
EC 3.1.1.23³ ⁸
Lipase Protein²
Monoacylglycerol Lipase ABHD6²

External Ids:	HGNC: 21398¹	Entrez Gene: 57406²	Ensembl: ENSG00000163686⁷	UniProtKB: Q9BV23³

Export aliases for ABHD6 gene to outside databases

Previous GC identifers: GC03P058078 GC03P058180

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ABHD6_HUMAN, Q9BV23

Function: Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid

signaling pathways (By similarity)

summary for ABHD6:

ABHD6 encodes a serine hydrolase enzyme known as alpha/beta-hydrolase domain 6. This enzyme catalyzes the

hydrolysis of 2-arachidonylglycerol.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ABHD6 gene promoter:
c-Fos AP-1 AML1a Bach2 JunB FosB Fra-1 HNF-4alpha2 JunD c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ABHD6 promoter sequence

Search SABiosciences Chromatin IP Primers for ABHD6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABHD6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.3 Ensembl cytogenetic band: 3p14.3 HGNC cytogenetic band: 3p21.2

ABHD6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABHD6 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P058198: view genomic region (about GC identifiers)

Start:	58,223,233 bp from pter	End:	58,281,420 bp from pter
Size:	58,188 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ABHD6_HUMAN, Q9BV23 (See protein sequence)

Recommended Name: Monoacylglycerol lipase ABHD6

Size: 337 amino acids; 38331 Da

Subcellular location: Membrane; Single-pass type II membrane protein (By similarity)

Secondary accessions: B2R7Y9 Q6ZMF7

Explore the universe of human proteins at neXtProt for ABHD6: NX_Q9BV23

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BV23

4/7 DME Specific Peptides for ABHD6 (Q9BV23) (see all 7)

IYYWYWRR

GQVKRIHQFVE

LQGLVDVRIPHN

LVCPAGLQYSTDN

ABHD6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_065727.4

ENSEMBL proteins:

ENSP00000420315 ENSP00000295962 ENSP00000418209 ENSP00000420408 ENSP00000418934

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals ABHD6 Protein Novus Biologicals ABHD6 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ABHD6

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--
GO:0016021	integral to membrane	IEA	--

ABHD6 for ontologies About GeneDecksing

ABHD6 Antibody Products:

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	Novus Biologicals ABHD6 Antibodies
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	Uscn Antibodies for ABHD6
	Search ThermoFisher Antibodies for ABHD6

Assay Products for ABHD6:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ABHD6
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ABHD6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ABHD6 for domains About GeneDecksing

2 InterPro domains/families:

IPR000073 AB_hydrolase_1

IPR000639 Epox_hydrolase-like

Graphical View of Domain Structure for InterPro Entry Q9BV23

ProtoNet protein and cluster: Q9BV23

3 Blocks protein families:

IPB000073 Alpha/beta hydrolase fold

IPB000639 Epoxide hydrolase signature

IPB003089 Alpha/beta hydrolase fold signature

UniProtKB/Swiss-Prot: ABHD6_HUMAN, Q9BV23

Similarity: Belongs to the AB hydrolase superfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ABHD6_HUMAN, Q9BV23

Function: Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid

signaling pathways (By similarity)

Catalytic activity: Hydrolyzes glycerol monoesters of long-chain fatty acids

Enzyme Number (IUBMB): EC 3.1.1.23¹ ²

miRNA Products:		OriGene 3'-UTR Clone: ABHD6 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ABHD6
		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate ABHD6 (see all 11):
		hsa-miR-4324 hsa-miR-1266 hsa-miR-125a-5p hsa-miR-137 hsa-miR-486-3p hsa-miR-432 hsa-miR-4260 hsa-miR-664

		SwitchGear 3'UTR luciferase reporter plasmid: ABHD6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABHD6 (see all 7) OriGene shRNA RFP: ABHD6 OriGene siRNA: ABHD6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABHD6

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ABHD6

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD6 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD6 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ABHD6 (NM_020676)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABHD6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABHD6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ABHD6
		Search LifeMap BioReagents cell lines for ABHD6

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABHD6

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0047372	acylglycerol lipase activity	IEA	--

ABHD6 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ABHD6:

Decreased viability of wild-ty

Animal Models:
1 MGI phenotypic allele

for Abhd6 (no phenotypes)

ABHD6 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

triacylglycerol degradation

triacylglycerol degradation

1.00

1 BioSystems Pathway for ABHD6

triacylglycerol degradation

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ABHD6

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for ABHD6 (ENSP00000295962⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	ENSP00000344818⁴	STRING: ENSP00000344818
CKMT2	ENSP00000254035⁴	STRING: ENSP00000254035
PCGF2	ENSP00000354033⁴	STRING: ENSP00000354033

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030336	negative regulation of cell migration	IEA	--
GO:0060292	long term synaptic depression	IEA	--
GO:2000124	regulation of endocannabinoid signaling pathway	IEA	--

ABHD6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for ABHD6 available from Tocris Bioscience About this table

Compound	Action	CAS #
WWL 70	Potent ABHD6 inhibitor	[947669-91-2]

Search CenterWatch for drugs/clinical trials and news about ABHD6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ABHD6 gene:

NM_020676.5

Unigene Cluster for ABHD6:

Abhydrolase domain containing 6

Hs.476454 [show with all ESTs]

Unigene Representative Sequence: AK225942

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000478253(uc003djt.4) ENST00000295962(uc003djs.4) ENST00000475982

ENST00000463756 ENST00000485900 ENST00000470440 ENST00000480457

miRNA Products:		OriGene 3'-UTR Clone: ABHD6 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ABHD6
		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate ABHD6 (see all 11):
		hsa-miR-4324 hsa-miR-1266 hsa-miR-125a-5p hsa-miR-137 hsa-miR-486-3p hsa-miR-432 hsa-miR-4260 hsa-miR-664

		SwitchGear 3'UTR luciferase reporter plasmid: ABHD6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABHD6 (see all 7) OriGene shRNA RFP: ABHD6 OriGene siRNA: ABHD6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABHD6

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD6 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD6 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ABHD6 (NM_020676)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABHD6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABHD6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABHD6 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABHD6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABHD6

Additional cDNA sequence:

AF225418.1 AK055828.1 AK092841.1 AK122983.1 AK172797.1 AK225942.1 AK313168.1 BC001698.2

10 DOTS entries:

DT.100022211 DT.100804023 DT.100777846 DT.447939 DT.100706283 DT.120887596 DT.91665716 DT.92428430

DT.95275499 DT.75130741

24/168 AceView cDNA sequences (see all 168):

AA554932 BI517499 BF939691 CB306972 BI761932 AI077708 AK055828 AI368377

CN484322 AI086303 BE858812 CR589982 AA889734 AA669791 AI016045 AA826493

BC001698 AA993799 BE218690 BI668176 AI079503 N39250 AI086248 AW615384

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ABHD6 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10a	·	10b
SP1:
SP2:							-
SP3:
SP4:							-

ECgene alternative splicing isoforms for ABHD6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ABHD6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

ABHD6 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ABHD6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ABHD6

SOURCE GeneReport for Unigene cluster: Hs.476454

SABiosciences Custom PCR Arrays for ABHD6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABHD6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ABHD6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABHD6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABHD6

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABHD6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ABHD6 gene from 5/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Abhd6^{1 , 5}	abhydrolase domain containing 6^{1, 5}	90.12(n)¹ 94.01(a)¹		14 (4.69 cM)⁵ 66082¹ NM_025341.3¹ NP_079617.2¹ 8002902⁵
chicken (Gallus gallus)	Aves	ABHD6¹	abhydrolase domain containing 6	74.93(n) 80.3(a)		416009 XM_414352.3 XP_414352.1
lizard (Anolis carolinensis)	Reptilia	ABHD6⁶ -- (see all 3)	--	75(a) 48(a) (see all 3)	1 ↔ 1 possible ortholog (see all 3)	2(163775696-163796181) 2(187338724-187350024)
African clawed frog (Xenopus laevis)	Amphibia	abhd6-prov²	abhydrolase domain containing 6	75.58(n)		BC054984.1
zebrafish (Danio rerio)	Actinopterygii	Dr.13980²	Transcribed sequences	74.54(n)		BM182875.1

ENSEMBL Gene Tree for ABHD6 (if available)
TreeFam Gene Tree for ABHD6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150023134^1,2		--	58221278(+)	`ACCTAA/GGTGGG`	1	--	us2k¹		0	--	--	--	--
rs182730863^1,2		--	58221290(+)	`TTCCTC/TAGTGA`	1	--	us2k¹		0	--	--	--	--
rs145343535^1,2		--	58221296(+)	`AGTGAC/TAGCAC`	1	--	us2k¹		0	--	--	--	--
rs116521314^1,2	C,	--	58221371(+)	`CACTGC/TAAAAC`	1	--	us2k¹		0	--	--	--	--
rs76048802^1,2	C,F,	--	58221409(+)	`AGCCAT/GCCAGT`	1	--	us2k¹		1		NA	120
rs73077957^1,2	F,	--	58221529(+)	`GGAGAC/AGCCCA`	1	--	us2k¹		1		NA	120
rs79050340^1,2		--	58221672(+)	`TCTAGG/ACTGGG`	1	--	us2k¹		1		WA	118
rs7640259^1,2	C,F,A,H,	--	58221822(+)	`TTGTGC/TTATCT`	1	--	us2k¹		37		NS EA NA WA CSA	3563
rs6445960^1,2	C,F,A,H,	--	58221932(+)	`CCGCTC/GTTTGG`	1	--	us2k¹		26		NS EA NA WA CSA	2500
rs11714675^1,2	H	--	58221973(+)	`ATTCCC/GTGAAG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ABHD6 (58223233 - 58281420 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ABHD6: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABHD6

DNA2.0 Custom Variant and Variant Library Synthesis for ABHD6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ABHD6 for disorders About GeneDecksing

20/26 diseases for ABHD6 (see all 26): About MalaCards

afferent loop syndrome cholesterol ester storage disease pityriasis versicolor exocrine pancreatic insufficiency

choledochal cyst infant botulism steatorrhea acinar cell carcinoma

wolman disease pancreatic steatorrhea alcohol abuse intestinal obstruction

familial hyperlipidemia panniculitis botulism hyperlipidemia

cystic fibrosis gallbladder disease hypercholesterolemia diarrhea

Export disorders for ABHD6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ABHD6 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with ABHD6)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
An unannotated alpha/beta hydrolase superfamily member, ABHD6 differentially expressed among cancer cell lines. (PubMed id 18360779)^{1, 9} Li F....Ji C. (2009)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
High expression of the evolutionarily conserved alpha /beta hydrolase domain containing 6 (ABHD6) in Ewing tumors. (PubMed id 19793082)¹ Max D....Staege M.S. (2009)
The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)² Muzny D.M....Gibbs R.A. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 57406	HGNC: 21398	AceView: ABHD6	Ensembl:ENSG00000163686	euGenes: HUgn57406
ECgene: ABHD6	H-InvDB: ABHD6

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ABHD6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ABHD6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ABHD6 gene:
Search GeneIP for patents involving ABHD6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
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	OriGene Antibodies for ABHD6		OriGene shRNA RFP for ABHD6
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABHD6		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABHD6
	OriGene Protein Over-expression Lysate for ABHD6		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for ABHD6		OriGene 3'-UTR Clone for ABHD6
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD6		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD6
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	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for ABHD6		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ABHD6		OriGene Custom Protein Services for ABHD6
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ABHD6
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABHD6
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABHD6
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABHD6
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	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABHD6

	GenScript Custom Purified and Recombinant Proteins Services for ABHD6		GenScript cDNA clones with any tag delivered in your preferred vector for ABHD6
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Search for Antibodies & Assays

	Regulatory tfbs in ABHD6 promoter
	Search Chromatin IP Primers for ABHD6
	RT² qPCR Primer Assay in human, mouse, rat ABHD6
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Tocris compounds for ABHD6

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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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	Search for Antibodies for ABHD6 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for ABHD6
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Browse ProSpec Recombinant Proteins

ABHD6 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for ABHD6

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABHD6

	SwitchGear 3'UTR luciferase reporter plasmids for ABHD6
	SwitchGear Promoter luciferase reporter plasmids for ABHD6

Search ThermoFisher Antibodies for ABHD6

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABHD6

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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ABHD6 Gene

abhydrolase domain containing 6

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ABHD6 Gene

abhydrolase domain containing 6

Aliasesfor ABHD6 gene

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Genomic Viewsfor ABHD6 gene

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Protein Domains /Familiesfor ABHD6 gene

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Specialized Databases showing ABHD6 gene

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Summaries
for ABHD6 gene

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for ABHD6 gene

Pathways & Interactions
for ABHD6 gene

Drugs & Compounds
for ABHD6 gene

Transcripts
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Expression
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Orthologs
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Genomic Variants
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Disorders / Diseases
for ABHD6 gene

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Intellectual Property
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