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Aliases for ABHD4 Gene

Aliases for ABHD4 Gene

  • Abhydrolase Domain Containing 4 2 3 5
  • Alpha/Beta Hydrolase Domain-Containing Protein 4 3 4
  • Lyso-N-Acylphosphatidylethanolamine Lipase 3 4
  • Abhydrolase Domain-Containing Protein 4 3 4
  • Alpha/Beta-Hydrolase 4 3 4
  • Protein ABHD4 3
  • EC 3.-.-.- 4
  • ABH4 3

External Ids for ABHD4 Gene

Previous GeneCards Identifiers for ABHD4 Gene

  • GC14P016854
  • GC14P021057
  • GC14P022136
  • GC14P023067
  • GC14P003185
  • GC14P022602
  • GC14P022684
  • GC14P022779
  • GC14P022868

Summaries for ABHD4 Gene

GeneCards Summary for ABHD4 Gene

ABHD4 (Abhydrolase Domain Containing 4) is a Protein Coding gene. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. GO annotations related to this gene include hydrolase activity and 1-alkyl-2-acetylglycerophosphocholine esterase activity. An important paralog of this gene is ABHD5.

UniProtKB/Swiss-Prot for ABHD4 Gene

  • Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD4 Gene

Genomics for ABHD4 Gene

Regulatory Elements for ABHD4 Gene

Enhancers for ABHD4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F022504 1.9 FANTOM5 Ensembl ENCODE 39.4 -60.1 -60050 66.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 MMP14 ABHD4 OXA1L LOC105370399 EFS HOMEZ C14orf119 DAD1 ENSG00000258457 TRAV37
GH14F022596 1.1 ENCODE 26.1 +0.2 171 3.0 HDGF CREB3L1 ARID4B SIN3A DMAP1 YBX1 YY1 ZNF207 FOS KLF13 ABHD4 EFS DAD1 ENSG00000275552
GH14F022587 1.5 FANTOM5 ENCODE 14 -9.2 -9164 3.2 MLX CREB3L1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MMP14 OXA1L DAD1 ABHD4 OR6J1 BCL2L2 HOMEZ LRP10 REM2 LOC105370400
GH14F022471 1.8 FANTOM5 Ensembl ENCODE 10.6 -110.2 -110175 32.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A YBX1 DMAP1 PRMT5-AS1 BCL2L2 ABHD4 HOMEZ MRPL52 SLC7A7 MMP14 OR6J1 TRAV18 TRAV8-5
GH14F022884 1.6 FANTOM5 Ensembl ENCODE 10.6 +288.6 288648 4.4 HDGF PKNOX1 ARNT SIN3A ZNF121 GLIS2 ZNF143 SP3 REST TBX21 PRMT5 HAUS4 MMP14 MRPL52 SLC7A7 ABHD4 CDH24 RBM23 REM2 PRMT5-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ABHD4 on UCSC Golden Path with GeneCards custom track

Promoters for ABHD4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001455936 263 1801 ATF1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 GLIS2 ZNF207 FOS

Genomic Location for ABHD4 Gene

Chromosome:
14
Start:
22,598,237 bp from pter
End:
22,613,215 bp from pter
Size:
14,979 bases
Orientation:
Plus strand

Genomic View for ABHD4 Gene

Genes around ABHD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABHD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABHD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD4 Gene

Proteins for ABHD4 Gene

  • Protein details for ABHD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TB40-ABHD4_HUMAN
    Recommended name:
    Protein ABHD4
    Protein Accession:
    Q8TB40
    Secondary Accessions:
    • B4DDH7
    • Q9H9E0

    Protein attributes for ABHD4 Gene

    Size:
    342 amino acids
    Molecular mass:
    38794 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABHD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABHD4 Gene

Post-translational modifications for ABHD4 Gene

  • Ubiquitination at Lys 192
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ABHD4 Gene

Domains & Families for ABHD4 Gene

Gene Families for ABHD4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TB40

UniProtKB/Swiss-Prot:

ABHD4_HUMAN :
  • Contains 1 AB hydrolase-1 (Alpha/Beta hydrolase fold 1) domain.
  • Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.
Domain:
  • Contains 1 AB hydrolase-1 (Alpha/Beta hydrolase fold 1) domain.
Family:
  • Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.
genes like me logo Genes that share domains with ABHD4: view

Function for ABHD4 Gene

Molecular function for ABHD4 Gene

UniProtKB/Swiss-Prot Function:
Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine (By similarity).

Enzyme Numbers (IUBMB) for ABHD4 Gene

Gene Ontology (GO) - Molecular Function for ABHD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity TAS --
GO:0052689 carboxylic ester hydrolase activity IBA --
genes like me logo Genes that share ontologies with ABHD4: view
genes like me logo Genes that share phenotypes with ABHD4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ABHD4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABHD4 Gene

Localization for ABHD4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABHD4 gene
Compartment Confidence
endoplasmic reticulum 4
nucleus 2
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ABHD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005811 lipid particle IBA --
genes like me logo Genes that share ontologies with ABHD4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ABHD4 Gene

Pathways & Interactions for ABHD4 Gene

genes like me logo Genes that share pathways with ABHD4: view

Interacting Proteins for ABHD4 Gene

Gene Ontology (GO) - Biological Process for ABHD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA,IBA --
GO:0006644 phospholipid metabolic process TAS --
GO:0016042 lipid catabolic process IEA --
GO:0019915 lipid storage IBA --
genes like me logo Genes that share ontologies with ABHD4: view

No data available for SIGNOR curated interactions for ABHD4 Gene

Drugs & Compounds for ABHD4 Gene

(1) Drugs for ABHD4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Anandamide Pharma Antagonist, Pore Blocker Endogenous CB receptor agonist 0

(4) Additional Compounds for ABHD4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PE(P-16:0e/16:0)
  • 2-Hexadecanoyl-1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine
PEP-16:0/18:1(11Z))
  • 1-(1-Enyl-palmitoyl)-2-vaccenoyl-sn-glycero-3-phosphoethanolamine
  • GPEtn(16:0/18:1)
  • GPEtn(16:0/18:1n7)
  • GPEtn(16:0/18:1w7)
  • GPEtn(34:1)
Phosphatidylethanolamines Group A
  • 1-(1-Enyl-stearoyl)-2-arachidonoyl-sn-glycero-3-phosphoethanolamine
  • 1-(1Z-Octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
  • 1-Alkenyl-2-acyl-glycerophosphoethanolamine
  • GPEtn(18:0/20:4)
  • GPEtn(18:0/20:4n6)
103597-60-0
Phosphatidylethanolamines Group B
  • 1-(1Z-Hexadecenyl)-sn-glycero-3-phosphoethanolamine
  • 2-Azaniumylethyl [(2R)-3-[(E)-hexadec-1-enoxy]-2-hydroxy-propyl] phosphate
  • LysoPE(dm16:0e)
  • 1-(1-Enyl-palmitoyl)-2-stearidonoyl-sn-glycero-3-phosphoethanolamine
  • GPEtn(16:0/18:4)
genes like me logo Genes that share compounds with ABHD4: view

Transcripts for ABHD4 Gene

Unigene Clusters for ABHD4 Gene

Abhydrolase domain containing 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - - - -
SP3: -
SP4:
SP5: -

Relevant External Links for ABHD4 Gene

GeneLoc Exon Structure for
ABHD4
ECgene alternative splicing isoforms for
ABHD4

Expression for ABHD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ABHD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ABHD4 Gene

This gene is overexpressed in Bone (42.2), Pancreatic juice (12.2), and Peripheral blood mononuclear cells (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABHD4 Gene



NURSA nuclear receptor signaling pathways regulating expression of ABHD4 Gene:

ABHD4

SOURCE GeneReport for Unigene cluster for ABHD4 Gene:

Hs.445665
genes like me logo Genes that share expression patterns with ABHD4: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ABHD4 Gene

Orthologs for ABHD4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABHD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABHD4 34 35
  • 99.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ABHD4 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abhd4 34 16 35
  • 90.94 (n)
cow
(Bos Taurus)
Mammalia ABHD4 34 35
  • 90.74 (n)
dog
(Canis familiaris)
Mammalia ABHD4 34 35
  • 90.35 (n)
rat
(Rattus norvegicus)
Mammalia Abhd4 34
  • 89.86 (n)
oppossum
(Monodelphis domestica)
Mammalia ABHD4 35
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABHD4 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd4 34
  • 70.27 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15564