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Aliases for ABHD4 Gene

Aliases for ABHD4 Gene

  • Abhydrolase Domain Containing 4 2 3 5
  • Alpha/Beta Hydrolase Domain-Containing Protein 4 3 4
  • Lyso-N-Acylphosphatidylethanolamine Lipase 3 4
  • Abhydrolase Domain-Containing Protein 4 3 4
  • Alpha/Beta-Hydrolase 4 3 4
  • Protein ABHD4 3
  • EC 3.-.-.- 4
  • ABH4 3

External Ids for ABHD4 Gene

Previous GeneCards Identifiers for ABHD4 Gene

  • GC14P016854
  • GC14P021057
  • GC14P022136
  • GC14P023067
  • GC14P003185
  • GC14P022602
  • GC14P022684
  • GC14P022779
  • GC14P022868
  • GC14P023826
  • GC14P023919

Summaries for ABHD4 Gene

GeneCards Summary for ABHD4 Gene

ABHD4 (Abhydrolase Domain Containing 4) is a Protein Coding gene. Among its related pathways are Metabolism and Acyl chain remodelling of PE. GO annotations related to this gene include hydrolase activity and 1-alkyl-2-acetylglycerophosphocholine esterase activity. An important paralog of this gene is ABHD5.

UniProtKB/Swiss-Prot for ABHD4 Gene

  • Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine (By similarity).

Additional gene information for ABHD4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD4 Gene

Genomics for ABHD4 Gene

Regulatory Elements for ABHD4 Gene

Enhancers for ABHD4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H022504 2.1 FANTOM5 Ensembl ENCODE dbSUPER 21.9 -60.1 -60050 66 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ABHD4 DAD1 C14orf93 MMP14 LOC105370399 TRAC NGDN OR6J1 MRPL52 SLC7A7
GH14H022976 1.9 FANTOM5 ENCODE dbSUPER 19.3 +381.7 381669 7 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 SP3 ACIN1 NGDN PRMT5 RBM23 C14orf93 HAUS4 MMP14 LOC102724814 PABPN1 SLC22A17
GH14H022596 1.3 ENCODE dbSUPER 26.1 +0.2 171 2 FOXA2 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS SP3 SP5 ABHD4 NGDN PRMT5 SLC7A8 DAD1 ENSG00000275552
GH14H022587 1.7 FANTOM5 ENCODE dbSUPER 14 -9.2 -9164 3 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 DAD1 ABHD4 PRMT5 OR6J1 SLC22A17 HOMEZ OXA1L MMP14 REM2 LINC02332
GH14H022472 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -109.7 -109690 31 HDGF PKNOX1 SIN3A YBX1 TCF12 GATA2 ZNF143 ZNF207 ATF7 RUNX3 PRMT5-AS1 ABHD4 MMP14 MRPL52 SLC7A7 OR6J1 TRAV18 TRAV8-5 REM2 RBM23
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ABHD4 on UCSC Golden Path with GeneCards custom track

Promoters for ABHD4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066612 363 1601 FOXA2 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 ZNF207 FOS SP3

Genomic Location for ABHD4 Gene

Chromosome:
14
Start:
22,598,237 bp from pter
End:
22,613,215 bp from pter
Size:
14,979 bases
Orientation:
Plus strand

Genomic View for ABHD4 Gene

Genes around ABHD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABHD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABHD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD4 Gene

Proteins for ABHD4 Gene

  • Protein details for ABHD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TB40-ABHD4_HUMAN
    Recommended name:
    Protein ABHD4
    Protein Accession:
    Q8TB40
    Secondary Accessions:
    • B4DDH7
    • Q9H9E0

    Protein attributes for ABHD4 Gene

    Size:
    342 amino acids
    Molecular mass:
    38794 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABHD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABHD4 Gene

Post-translational modifications for ABHD4 Gene

  • Ubiquitination at Lys192
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ABHD4 Gene

Domains & Families for ABHD4 Gene

Gene Families for ABHD4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q8TB40

UniProtKB/Swiss-Prot:

ABHD4_HUMAN :
  • Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.
Family:
  • Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.
genes like me logo Genes that share domains with ABHD4: view

Function for ABHD4 Gene

Molecular function for ABHD4 Gene

UniProtKB/Swiss-Prot Function:
Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine (By similarity).

Enzyme Numbers (IUBMB) for ABHD4 Gene

Phenotypes From GWAS Catalog for ABHD4 Gene

Gene Ontology (GO) - Molecular Function for ABHD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity TAS --
genes like me logo Genes that share ontologies with ABHD4: view
genes like me logo Genes that share phenotypes with ABHD4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ABHD4

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ABHD4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABHD4 Gene

Localization for ABHD4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABHD4 gene
Compartment Confidence
endoplasmic reticulum 4
nucleus 2
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ABHD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with ABHD4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ABHD4 Gene

Pathways & Interactions for ABHD4 Gene

genes like me logo Genes that share pathways with ABHD4: view

Interacting Proteins for ABHD4 Gene

Gene Ontology (GO) - Biological Process for ABHD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0016042 lipid catabolic process IEA --
GO:0036152 phosphatidylethanolamine acyl-chain remodeling TAS --
genes like me logo Genes that share ontologies with ABHD4: view

No data available for SIGNOR curated interactions for ABHD4 Gene

Drugs & Compounds for ABHD4 Gene

(1) Drugs for ABHD4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Anandamide Pharma Antagonist, Pore Blocker Endogenous CB receptor agonist 0

(4) Additional Compounds for ABHD4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PE(P-16:0e/16:0)
  • 2-Hexadecanoyl-1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine
PEP-16:0/18:1(11Z))
  • 1-(1-Enyl-palmitoyl)-2-vaccenoyl-sn-glycero-3-phosphoethanolamine
  • GPEtn(16:0/18:1)
  • GPEtn(16:0/18:1n7)
  • GPEtn(16:0/18:1w7)
  • GPEtn(34:1)
Phosphatidylethanolamines Group A
  • 1-(1-Enyl-stearoyl)-2-arachidonoyl-sn-glycero-3-phosphoethanolamine
  • 1-(1Z-Octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
  • 1-Alkenyl-2-acyl-glycerophosphoethanolamine
  • GPEtn(18:0/20:4)
  • GPEtn(18:0/20:4n6)
103597-60-0
Phosphatidylethanolamines Group B
  • 1-(1Z-Hexadecenyl)-sn-glycero-3-phosphoethanolamine
  • 2-Azaniumylethyl [(2R)-3-[(E)-hexadec-1-enoxy]-2-hydroxy-propyl] phosphate
  • LysoPE(dm16:0e)
  • 2-(9Z-Octadecanoyl)-1-hexadecyl-sn-glycero-3-phosphoethanolamine
  • 1-(1-Enyl-palmitoyl)-2-a-linolenoyl-sn-glycero-3-phosphoethanolamine
genes like me logo Genes that share compounds with ABHD4: view

Transcripts for ABHD4 Gene

Unigene Clusters for ABHD4 Gene

Abhydrolase domain containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ABHD4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - - - -
SP3: -
SP4:
SP5: -

Relevant External Links for ABHD4 Gene

GeneLoc Exon Structure for
ABHD4
ECgene alternative splicing isoforms for
ABHD4

Expression for ABHD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ABHD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ABHD4 Gene

This gene is overexpressed in Bone (42.2), Pancreatic juice (12.2), and Peripheral blood mononuclear cells (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ABHD4 Gene



NURSA nuclear receptor signaling pathways regulating expression of ABHD4 Gene:

ABHD4

SOURCE GeneReport for Unigene cluster for ABHD4 Gene:

Hs.445665

Evidence on tissue expression from TISSUES for ABHD4 Gene

  • Adrenal gland(4.2)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with ABHD4: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABHD4 Gene

Orthologs for ABHD4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABHD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABHD4 33 34
  • 99.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ABHD4 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abhd4 33 16 34
  • 90.94 (n)
cow
(Bos Taurus)
Mammalia ABHD4 33 34
  • 90.74 (n)
dog
(Canis familiaris)
Mammalia ABHD4 33 34
  • 90.35 (n)
rat
(Rattus norvegicus)
Mammalia Abhd4 33
  • 89.86 (n)
oppossum
(Monodelphis domestica)
Mammalia ABHD4 34
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABHD4 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd4 33
  • 70.27 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15564 33
zebrafish
(Danio rerio)
Actinopterygii abhd4 33 34
  • 62.71 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1882 33 34
  • 56.12 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000784 33
  • 52.85 (n)
worm
(Caenorhabditis elegans)
Secernentea C37H5.3 33 34
  • 51.02 (n)
C37H5.2 34
  • 38 (a)
ManyToMany
lid-1 34
  • 38 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLD1 34
  • 18 (a)
OneToMany
ICT1 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G24160 33
  • 45.22 (n)
rice
(Oryza sativa)
Liliopsida Os09g0520200 33
  • 47.6 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
ManyToMany
-- 34
  • 44 (a)
ManyToMany
Species where no ortholog for ABHD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABHD4 Gene

ENSEMBL:
Gene Tree for ABHD4 (if available)
TreeFam:
Gene Tree for ABHD4 (if available)

Paralogs for ABHD4 Gene

Paralogs for ABHD4 Gene

(1) SIMAP similar genes for ABHD4 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ABHD4: view

Variants for ABHD4 Gene

Sequence variations from dbSNP and Humsavar for ABHD4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000184763 -- 22,600,513(+) GGATG(C/T)CCAGT intron-variant
rs1000362752 -- 22,607,530(+) GGGCA(C/G)TGTGT intron-variant
rs1000403768 -- 22,602,402(+) GGGCC(C/T)GAGTA intron-variant
rs1000652725 -- 22,597,270(+) GACTG(A/C)AAGTG upstream-variant-2KB
rs1001284841 -- 22,600,841(+) GTGTG(G/T)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABHD4 Gene

Variant ID Type Subtype PubMed ID
esv3633758 CNV loss 21293372
esv3892469 CNV gain+loss 25118596
nsv520576 CNV loss 19592680
nsv563998 CNV gain 21841781
nsv832746 CNV gain 17160897
nsv832748 CNV gain 17160897

Variation tolerance for ABHD4 Gene

Residual Variation Intolerance Score: 15.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABHD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABHD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABHD4 Gene

Disorders for ABHD4 Gene

Relevant External Links for ABHD4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABHD4

No disorders were found for ABHD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABHD4 Gene

Publications for ABHD4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. A genome wide shRNA screen identifies α/β hydrolase domain containing 4 (ABHD4) as a novel regulator of anoikis resistance. (PMID: 22488300) Simpson CD … Schimmer AD (Apoptosis : an international journal on programmed cell death 2012) 3 60
  4. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A … Wanker EE (Science signaling 2011) 3 60
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 60

Products for ABHD4 Gene

Sources for ABHD4 Gene

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