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Aliases for ABHD4 Gene

Aliases for ABHD4 Gene

  • Abhydrolase Domain Containing 4 2 3
  • Lyso-N-Acylphosphatidylethanolamine Lipase 3 4
  • Alpha/Beta-Hydrolase 4 3 4
  • Abhydrolase Domain-Containing Protein 4 3
  • EC 3.1.1.- 4
  • ABH4 3

External Ids for ABHD4 Gene

Summaries for ABHD4 Gene

GeneCards Summary for ABHD4 Gene

ABHD4 (Abhydrolase Domain Containing 4) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is ABHD5.

UniProtKB/Swiss-Prot for ABHD4 Gene

  • Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD4 Gene

Genomics for ABHD4 Gene

Genomic Location for ABHD4 Gene

Start:
22,598,237 bp from pter
End:
22,613,215 bp from pter
Size:
14,979 bases
Orientation:
Plus strand

Genomic View for ABHD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABHD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD4 Gene

Regulatory Elements for ABHD4 Gene

Proteins for ABHD4 Gene

  • Protein details for ABHD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TB40-ABHD4_HUMAN
    Recommended name:
    Abhydrolase domain-containing protein 4
    Protein Accession:
    Q8TB40
    Secondary Accessions:
    • B4DDH7
    • Q9H9E0

    Protein attributes for ABHD4 Gene

    Size:
    342 amino acids
    Molecular mass:
    38794 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABHD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABHD4 Gene

Proteomics data for ABHD4 Gene at MOPED

Post-translational modifications for ABHD4 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys192

Other Protein References for ABHD4 Gene

No data available for DME Specific Peptides for ABHD4 Gene

Domains for ABHD4 Gene

Gene Families for ABHD4 Gene

HGNC:
  • ABHD :Abhydrolase domain containing

UniProtKB/Swiss-Prot:

ABHD4_HUMAN
Family:
  • Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.:
    • Q8TB40
genes like me logo Genes that share domains with ABHD4: view

Function for ABHD4 Gene

Molecular function for ABHD4 Gene

UniProtKB/Swiss-Prot Function: Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine (By similarity).

Enzyme Numbers (IUBMB) for ABHD4 Gene

Gene Ontology (GO) - Molecular Function for ABHD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ABHD4: view

miRNA for ABHD4 Gene

miRTarBase miRNAs that target ABHD4

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ABHD4 Gene

Localization for ABHD4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABHD4 Gene COMPARTMENTS Subcellular localization image for ABHD4 gene
Compartment Confidence
cytosol 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ABHD4 Gene

Pathways for ABHD4 Gene

SuperPathways for ABHD4 Gene

No Data Available

Interacting Proteins for ABHD4 Gene

Gene Ontology (GO) - Biological Process for ABHD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with ABHD4: view

No data available for Pathways by source for ABHD4 Gene

Compounds for ABHD4 Gene

(1076) HMDB Compounds for ABHD4 Gene

Compound Synonyms Cas Number PubMed IDs
Anandamide
  • Anandamide (20.4, n-6)
94421-68-8
PE(14:0/14:0)
  • Phophatidylethanolamine(14:0/14:0)
Not Available
PE(14:0/14:1(9Z))
  • PE(28:1)
Not Available
PE(14:0/15:0)
  • GPEtn(14:0/15:0)
Not Available
PE(14:0/16:0)
  • PE(14:0/16:0)
Not Available
genes like me logo Genes that share compounds with ABHD4: view

Transcripts for ABHD4 Gene

Unigene Clusters for ABHD4 Gene

Abhydrolase domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - - - -
SP3: -
SP4:
SP5: -

Relevant External Links for ABHD4 Gene

GeneLoc Exon Structure for
ABHD4
ECgene alternative splicing isoforms for
ABHD4

Expression for ABHD4 Gene

mRNA expression in normal human tissues for ABHD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABHD4 Gene

SOURCE GeneReport for Unigene cluster for ABHD4 Gene Hs.445665

genes like me logo Genes that share expressions with ABHD4: view

Orthologs for ABHD4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABHD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABHD4 36
  • 99.32 (n)
  • 100 (a)
ABHD4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ABHD4 36
  • 90.74 (n)
  • 95.03 (a)
ABHD4 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABHD4 36
  • 90.35 (n)
  • 95.91 (a)
ABHD4 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abhd4 36
  • 90.94 (n)
  • 96.49 (a)
Abhd4 16
Abhd4 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABHD4 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABHD4 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abhd4 36
  • 89.86 (n)
  • 96.2 (a)
lizard
(Anolis carolinensis)
Reptilia ABHD4 37
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15564 36
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd4 36
  • 70.27 (n)
  • 74.85 (a)
zebrafish
(Danio rerio)
Actinopterygii abhd4 36
  • 62.71 (n)
  • 64.39 (a)
abhd4 37
  • 54 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000784 36
  • 52.85 (n)
  • 46.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1882 36
  • 56.12 (n)
  • 48.96 (a)
CG1882 37
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C37H5.2 37
  • 38 (a)
ManyToMany
C37H5.3 36
  • 51.02 (n)
  • 45.95 (a)
C37H5.3 37
  • 32 (a)
ManyToMany
lid-1 37
  • 38 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLD1 37
  • 18 (a)
OneToMany
ICT1 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G24160 36
  • 45.22 (n)
  • 36.62 (a)
rice
(Oryza sativa)
Liliopsida Os09g0520200 36
  • 47.6 (n)
  • 38.43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 47 (a)
ManyToMany
-- 37
  • 44 (a)
ManyToMany
Species with no ortholog for ABHD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABHD4 Gene

ENSEMBL:
Gene Tree for ABHD4 (if available)
TreeFam:
Gene Tree for ABHD4 (if available)

Paralogs for ABHD4 Gene

Paralogs for ABHD4 Gene

Selected SIMAP similar genes for ABHD4 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ABHD4: view

Variants for ABHD4 Gene

Sequence variations from dbSNP and Humsavar for ABHD4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs9339 -- 22,612,317(+) CTGCC(C/T)TGGGC utr-variant-3-prime, nc-transcript-variant
rs970348 -- 22,600,948(+) AAAAC(A/G)GGATG intron-variant
rs1017873 -- 22,596,520(+) TGAGA(C/G)CCCAA upstream-variant-2KB
rs1242921 -- 22,604,646(+) ACTCT(A/G)TCTCC intron-variant
rs1242922 -- 22,604,702(+) CCTCC(C/T)GGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABHD4 Gene

Variant ID Type Subtype PubMed ID
nsv832746 CNV Gain 17160897
nsv832748 CNV Gain 17160897
nsv520576 CNV Loss 19592680

Relevant External Links for ABHD4 Gene

HapMap Linkage Disequilibrium report
ABHD4

Disorders for ABHD4 Gene

No disorders were found for ABHD4 Gene.

No data available for UniProtKB/Swiss-Prot for ABHD4 Gene

Publications for ABHD4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway. (PMID: 16818490) Simon G.M. … Cravatt B.F. (J. Biol. Chem. 2006) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for ABHD4 Gene

Sources for ABHD4 Gene

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