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ABHD4 Gene

protein-coding   GIFtS: 52
GCID: GC14P023067

Abhydrolase Domain Containing 4

  Search for ABHD4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Abhydrolase Domain Containing 41 2
Alpha/Beta-Hydrolase 42 3
Lyso-N-Acylphosphatidylethanolamine Lipase2 3
ABH42
Abhydrolase Domain-Containing Protein 42
EC 3.1.1.-3

External Ids:    HGNC: 201541   Entrez Gene: 638742   Ensembl: ENSG000001004397   UniProtKB: Q8TB403   

Export aliases for ABHD4 gene to outside databases

Previous GC identifers: GC14P016854 GC14P021057 GC14P022136 GC14P003185


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ABHD4 Gene:
ABHD4 (abhydrolase domain containing 4) is a protein-coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is ABHD5.

UniProtKB/Swiss-Prot: ABHD4_HUMAN, Q8TB40
Function: Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis
of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains
from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an
intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated,
polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including
lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ABHD4 gene promoter:
         TBP   Sp1   p53   Pax-2   Pax-2a   POU3F2   CREB   Pax-2b   deltaCREB   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidABHD4 promoter sequence
   Search Chromatin IP Primers for ABHD4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ABHD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.1

ABHD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABHD4 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P023067:  view genomic region     (about GC identifiers)

Start:
23,067,146 bp from pter      End:
23,081,265 bp from pter
Size:
14,120 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ABHD4_HUMAN, Q8TB40 (See protein sequence)
Recommended Name: Abhydrolase domain-containing protein 4  
Size: 342 amino acids; 38794 Da
Caution: Thr-291 is present instead of the conserved His which is expected to be an active site residue
Secondary accessions: Q9H9E0

Explore the universe of human proteins at neXtProt for ABHD4: NX_Q8TB40

Explore proteomics data for ABHD4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys192
  • Modification sites at PhosphoSitePlus

  • See ABHD4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071343.2  
    ENSEMBL proteins: 
     ENSP00000414558   ENSP00000216327   ENSP00000438332   ENSP00000437385   ENSP00000388751  
     ENSP00000444550   ENSP00000438014  

    ABHD4 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ABHD4
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    Novus Biologicals ABHD4 Protein
    Novus Biologicals ABHD4 Lysate
    Sino Biological Recombinant Protein for ABHD4
    Sino Biological Cell Lysate for ABHD4
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    Cloud-Clone Corp. Proteins for ABHD4

     
    Search eBioscience for Proteins for ABHD4 

    ABHD4 Antibody Products:

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    Abcam antibodies for ABHD4
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    LSBio Antibodies in human, mouse, rat for ABHD4

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    Search eBioscience for ELISAs for ABHD4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ABHD: Abhydrolase domain containing

    1 InterPro protein domain:
     IPR000073 AB_hydrolase_1

    Graphical View of Domain Structure for InterPro Entry Q8TB40

    ProtoNet protein and cluster: Q8TB40

    2 Blocks protein domains:
    IPB000073 Alpha/beta hydrolase fold
    IPB002410 Prolyl aminopeptidase (S33) family signature


    UniProtKB/Swiss-Prot: ABHD4_HUMAN, Q8TB40
    Similarity: Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily


    Find genes that share domains with ABHD4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ABHD4_HUMAN, Q8TB40
    Function: Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis
    of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains
    from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an
    intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated,
    polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including
    lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine (By similarity)

         Enzyme Number (IUBMB): EC 3.1.1.-1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016787hydrolase activity IEA--
         
    Find genes that share ontologies with ABHD4           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ABHD4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ABHD4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ABHD4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ABHD4

    miRNA
    Products:
        
    miRTarBase miRNAs that target ABHD4:
    hsa-mir-335-5p (MIRT017840), hsa-mir-124-3p (MIRT022630), hsa-mir-375 (MIRT019813)

    Block miRNA regulation of human, mouse, rat ABHD4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ABHD4 (see all 33):
    hsa-miR-1321 hsa-miR-631 hsa-miR-199a-3p hsa-miR-29a hsa-miR-486-3p hsa-miR-877* hsa-miR-124 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidABHD4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ABHD4

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: ABHD4 (NM_022060)
    Sino Biological Human cDNA Clone for ABHD4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABHD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABHD4

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABHD4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol1
    nucleus1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ABHD4
    Interactions:

        Search GeneGlobe Interaction Network for ABHD4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for ABHD4 (Q8TB402, 3 ENSP000002163274) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8252945 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8252945 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8252945 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8252945 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8252945 I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016042lipid catabolic process IEA--

    Find genes that share ontologies with ABHD4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ABHD4

    Selected HMDB Compounds for ABHD4 (see all 1076)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)--12486725
    PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)103597-60-012486725
    PE(P-16:0e/0:0)2-azaniumylethyl [(2R)-3-[(E)-hexadec-1-enoxy]-2-hydroxy-propyl] phosphate;1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine ;LysoPE(dm16:0e) --12486725
    PE(P-16:0e/18:1(9Z))2-(9Z-octadecanoyl)-1-hexadecyl-sn-glycero-3-phosphoethanolamine --12486725
    AnandamideAnandamide (20.4, n-6) (see all 13)94421-68-8--
    PE(14:0/14:0)Phophatidylethanolamine(14:0/14:0) (see all 7)----
    PE(14:0/14:1(9Z))PE(28:1) (see all 13)----
    PE(14:0/15:0)GPEtn(14:0/15:0) (see all 7)----
    PE(14:0/16:0)PE(14:0/16:0) (see all 7)----
    PE(14:0/16:1(9Z))PE(14:0/16:1n7) (see all 13)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ABHD4 gene: 
    NM_022060.2  

    Unigene Cluster for ABHD4:

    Abhydrolase domain containing 4
    Hs.445665  [show with all ESTs]
    Unigene Representative Sequence: NM_022060
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000428304(uc010tna.1 uc001wgm.3 uc010tnb.2) ENST00000216327
    ENST00000537243 ENST00000544562 ENST00000542041 ENST00000539344(uc010tmz.1)
    ENST00000418446 ENST00000545034 ENST00000541962 ENST00000489928
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ABHD4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ABHD4 (see all 33):
    hsa-miR-1321 hsa-miR-631 hsa-miR-199a-3p hsa-miR-29a hsa-miR-486-3p hsa-miR-877* hsa-miR-124 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidABHD4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ABHD4
    Predesigned siRNA for gene silencing in human, mouse, rat ABHD4
    Clone
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    OriGene clones in human, mouse for ABHD4 (see all 7)
    OriGene ORF clones in mouse, rat for ABHD4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ABHD4 (NM_022060)
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    Primer
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    OriGene qPCR primer pairs and template standards for ABHD4
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      QuantiTect SYBR Green Assays in human, mouse, rat ABHD4
      QuantiFast Probe-based Assays in human, mouse, rat ABHD4

    Additional mRNA sequence: 

    AK022878.1 AK024790.1 AK293198.1 AK298127.1 AK301315.1 BC024779.1 

    7 DOTS entries:

    DT.111772  DT.402733  DT.95271266  DT.102831536  DT.120746454  DT.92387876  DT.120746442 

    Selected AceView cDNA sequences (see all 146):

    BM977681 NM_022060 BQ933353 CB216203 BU192139 BI829156 CB529668 BM466288 
    AL041951 BM713221 CR610790 C01492 CD518051 CN484948 BM762794 AI668845 
    BU507199 CF272334 BM996134 BX393729 CD559115 BM558186 BM802713 AI026819 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ABHD4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:              -                       -           -                     
    SP2:              -                       -     -     -                     
    SP3:              -                                                         
    SP4:                                                                        
    SP5:                                      -                                 


    ECgene alternative splicing isoforms for ABHD4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ABHD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTCCAGCT
    ABHD4 Expression
    About this image


    ABHD4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Thalamus
    ABHD4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ABHD4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445665
        Custom PCR Arrays for ABHD4
    Primer
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    QuantiTect SYBR Green Assays in human, mouse, rat ABHD4
    QuantiFast Probe-based Assays in human, mouse, rat ABHD4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABHD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ABHD4 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Abhd41 , 5 abhydrolase domain containing 41, 5 90.94(n)1
    96.49(a)1
      14 (27.71 cM)5
    1055011  NM_134076.21  NP_598837.21 
     542541295 
    lizard
    (Anolis carolinensis)
    Reptilia ABHD46
    abhydrolase domain containing 4
    77(a)
    1 ↔ 1
    GL343979.1(87482-93815)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.155642 Xenopus laevis transcribed sequence with moderate similarity more 74.49(n)    CF342070.1 
    zebrafish
    (Danio rerio)
    Actinopterygii abhd41 abhydrolase domain containing 4 62.71(n)
    64.39(a)
      550276  NM_001017613.1  NP_001017613.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG18821 CG1882 56.12(n)
    48.96(a)
      35733  NM_136482.1  NP_610326.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C37H5.31 C37H5.3 51.02(n)
    45.95(a)
      178877  NM_071896.4  NP_504297.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ICT1(YLR099C)4 Lysophosphatidic acid acyltransferase, responsible more   --   12(340928-339744) 850788  NP_013200.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G241601 AT4G24160 45.22(n)
    36.62(a)
      828516  NM_118548.2  NP_194147.2 
    rice
    (Oryza sativa)
    Liliopsida Os09g05202001 Os09g0520200 47.6(n)
    38.43(a)
      4347605  NM_001070232.2  NP_001063697.2 


    ENSEMBL Gene Tree for ABHD4 (if available)
    TreeFam Gene Tree for ABHD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ABHD4 gene
    ABHD52  
    1 SIMAP similar gene for ABHD4 using alignment to 7 protein entries:     ABHD4_HUMAN (see all proteins):
    ABHD5

    Find genes that share paralogs with ABHD4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ABHD4 (see all 367)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1153573161,2
    C,F--4062738(+) TTGAAC/TGAAGC 1 -- us2k11Minor allele frequency- T:0.09WA 118
    rs10178731,2
    C,F,A--4062785(+) TGAGAC/GCCCAA 1 -- us2k110Minor allele frequency- G:0.49NA WA CSA EA 372
    rs746814091,2
    C--4062972(+) TCATGA/GCACTG 1 -- us2k14Minor allele frequency- G:0.12CSA WA NA EA 360
    rs342913831,2
    C--4063012(+) GTCTC-/AAAAAA 1 -- us2k10--------
    rs1165022641,2
    C,F--4063047(+) GTCCTC/TTGCTA 1 -- us2k11Minor allele frequency- T:0.10WA 118
    rs801286181,2
    C,F--4063124(+) CTAAAC/TGTTAA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1894569421,2
    --4063311(+) TTTTGC/GTTTTT 1 -- us2k10--------
    rs1813792461,2
    C--4063341(+) TCTCTC/GAGGCT 1 -- us2k10--------
    rs1857874061,2
    --4063355(+) GTGCAC/GTGTCA 1 -- us2k10--------
    rs1429947161,2
    C--4063372(+) TGGCTC/TACTGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ABHD4 (23067146 - 23081265 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ABHD4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv520576CNV Loss19592680
    nsv832746CNV Gain17160897
    nsv832748CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ABHD4 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with ABHD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. A genome wide shRNA screen identifies I+/I^ hydrolase domain containing 4 (ABHD4) as a novel regulator of anoikis resistance. (PubMed id 22488300)1 Simpson C.D....Schimmer A.D. (Apoptosis 2012)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    8. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway. (PubMed id 16818490)1 Simon G.M. and Cravatt B.F. (J. Biol. Chem. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 63874 HGNC: 20154 AceView: ABHD4 Ensembl:ENSG00000100439 euGenes: HUgn63874
    ECgene: ABHD4 H-InvDB: ABHD4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ABHD4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ABHD4 gene:
    Search GeneIP for patents involving ABHD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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