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Aliases for ABHD3 Gene

Aliases for ABHD3 Gene

  • Abhydrolase Domain Containing 3 2 3
  • Abhydrolase Domain-Containing Protein 3 3 4
  • LABH3 3 6
  • Alpha/Beta Hydrolase Domain Containing Protein 3 3
  • Lung Alpha/Beta Hydrolase 3 3
  • Phospholipase ABHD3 3
  • EC 3.1.1.32 4
  • EC 3.1.1.4 4
  • EC 3.1.1 64

External Ids for ABHD3 Gene

Summaries for ABHD3 Gene

Entrez Gene Summary for ABHD3 Gene

  • This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of enzymes. The function of this protein has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABHD3 Gene

ABHD3 (Abhydrolase Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is ABHD1.

UniProtKB/Swiss-Prot for ABHD3 Gene

  • Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD3 Gene

Genomics for ABHD3 Gene

Genomic Location for ABHD3 Gene

Start:
21,650,897 bp from pter
End:
21,704,805 bp from pter
Size:
53,909 bases
Orientation:
Minus strand

Genomic View for ABHD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABHD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD3 Gene

Regulatory Elements for ABHD3 Gene

Proteins for ABHD3 Gene

  • Protein details for ABHD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WU67-ABHD3_HUMAN
    Recommended name:
    Phospholipase ABHD3
    Protein Accession:
    Q8WU67
    Secondary Accessions:
    • B0YIV0
    • B7Z5C2
    • O43411

    Protein attributes for ABHD3 Gene

    Size:
    409 amino acids
    Molecular mass:
    46009 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC19155.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ABHD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABHD3 Gene

Proteomics data for ABHD3 Gene at MOPED

Selected DME Specific Peptides for ABHD3 Gene

Post-translational modifications for ABHD3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys288 and Lys332

Other Protein References for ABHD3 Gene

Domains for ABHD3 Gene

Gene Families for ABHD3 Gene

HGNC:
  • ABHD :Abhydrolase domain containing

UniProtKB/Swiss-Prot:

ABHD3_HUMAN
Family:
  • Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.:
    • Q8WU67
genes like me logo Genes that share domains with ABHD3: view

Function for ABHD3 Gene

Molecular function for ABHD3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot CatalyticActivity: Phosphatidylcholine + H(2)O = 2-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot Function: Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids.

Enzyme Numbers (IUBMB) for ABHD3 Gene

Gene Ontology (GO) - Molecular Function for ABHD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function --
GO:0004623 phospholipase A2 activity IMP 21926997
GO:0008970 phosphatidylcholine 1-acylhydrolase activity IMP 21926997
GO:0052689 carboxylic ester hydrolase activity --
GO:0052739 phosphatidylserine 1-acylhydrolase activity IEA --
genes like me logo Genes that share ontologies with ABHD3: view

miRNA for ABHD3 Gene

miRTarBase miRNAs that target ABHD3

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ABHD3 Gene

Localization for ABHD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABHD3 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABHD3 Gene COMPARTMENTS Subcellular localization image for ABHD3 gene
Compartment Confidence
golgi apparatus 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ABHD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ABHD3: view

Pathways for ABHD3 Gene

SuperPathways for ABHD3 Gene

No Data Available

Interacting Proteins for ABHD3 Gene

Gene Ontology (GO) - Biological Process for ABHD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process --
GO:0008152 metabolic process --
GO:0046470 phosphatidylcholine metabolic process IMP 21926997
genes like me logo Genes that share ontologies with ABHD3: view

No data available for Pathways by source for ABHD3 Gene

Transcripts for ABHD3 Gene

Unigene Clusters for ABHD3 Gene

Abhydrolase domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - - -
SP2: - - -
SP3: - - - - - -
SP4: - -
SP5: - -
SP6:
SP7:

Relevant External Links for ABHD3 Gene

GeneLoc Exon Structure for
ABHD3
ECgene alternative splicing isoforms for
ABHD3

Expression for ABHD3 Gene

mRNA expression in normal human tissues for ABHD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABHD3 Gene

SOURCE GeneReport for Unigene cluster for ABHD3 Gene Hs.397978

genes like me logo Genes that share expressions with ABHD3: view

Orthologs for ABHD3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABHD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABHD3 36
  • 99.76 (n)
  • 99.76 (a)
ABHD3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ABHD3 36
  • 91.12 (n)
  • 95.6 (a)
ABHD3 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABHD3 36
  • 91.18 (n)
  • 95.83 (a)
ABHD3 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abhd3 36
  • 86.63 (n)
  • 93.4 (a)
Abhd3 16
Abhd3 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABHD3 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABHD3 37
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abhd3 36
  • 87.53 (n)
  • 93.4 (a)
chicken
(Gallus gallus)
Aves ABHD3 36
  • 78.33 (n)
  • 80.89 (a)
ABHD3 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABHD3 37
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11489 36
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd3 36
  • 72.77 (n)
  • 75.25 (a)
Str.12375 36
zebrafish
(Danio rerio)
Actinopterygii abhd3 36
  • 65.61 (n)
  • 66.75 (a)
abhd3 37
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006819 36
  • 48.08 (n)
  • 41.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hydr1 36
  • 48.18 (n)
  • 42.08 (a)
Hydr1 37
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C44C1.5 37
  • 30 (a)
ManyToMany
CELE_Y60A3A.7 36
  • 45.54 (n)
  • 33.72 (a)
Y60A3A.7 37
  • 31 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 19 (a)
ManyToMany
EEB1 37
  • 22 (a)
ManyToMany
EHT1 37
  • 21 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G50790 36
  • 46.38 (n)
  • 35.2 (a)
rice
(Oryza sativa)
Liliopsida Os02g0649400 36
  • 46.38 (n)
  • 35.2 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2629 37
  • 37 (a)
OneToMany
Species with no ortholog for ABHD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABHD3 Gene

ENSEMBL:
Gene Tree for ABHD3 (if available)
TreeFam:
Gene Tree for ABHD3 (if available)

Paralogs for ABHD3 Gene

Paralogs for ABHD3 Gene

Selected SIMAP similar genes for ABHD3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ABHD3: view

Variants for ABHD3 Gene

Sequence variations from dbSNP and Humsavar for ABHD3 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs2155672 -- 21,696,245(-) AATGT(C/T)GTGAA intron-variant
rs2155673 -- 21,696,144(-) aaaca(A/G)ggaga intron-variant
rs2186896 -- 21,696,379(-) AAGGT(C/T)AGGAG intron-variant
rs2305684 -- 21,663,703(-) TGCAG(C/T)GGCCT intron-variant, nc-transcript-variant
rs2510529 -- 21,661,518(-) gagta(A/G/T)ctagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABHD3 Gene

Variant ID Type Subtype PubMed ID
nsv909448 CNV Gain 21882294
nsv909449 CNV Gain 21882294
esv29974 CNV Loss 17803354
esv2716850 CNV Deletion 23290073

Relevant External Links for ABHD3 Gene

HapMap Linkage Disequilibrium report
ABHD3

Disorders for ABHD3 Gene

Relevant External Links for ABHD3

Genetic Association Database (GAD)
ABHD3
genes like me logo Genes that share disorders with ABHD3: view

No data available for UniProtKB/Swiss-Prot for ABHD3 Gene

Publications for ABHD3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Metabolomics annotates ABHD3 as a physiologic regulator of medium- chain phospholipids. (PMID: 21926997) Long J.Z. … Cravatt B.F. (Nat. Chem. Biol. 2011) 3 4
  3. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PMID: 22359512) Demirkan A. … Schmitz G. (PLoS Genet. 2012) 3 49
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C. … Lander E.S. (Nature 2005) 4

Products for ABHD3 Gene

Sources for ABHD3 Gene

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