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ABHD2 Gene

protein-coding   GIFtS: 52
GCID: GC15P089631

Abhydrolase Domain Containing 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Abhydrolase Domain Containing 21 2     PHPS1-22
LABH22 3 5     Abhydrolase Domain-Containing Protein 22
Lung Alpha/Beta Hydrolase 22 3     Alpha/Beta Hydrolase Domain Containing Protein 22
Protein PHPS1-22 3     EC 3.1.1.-3
HS1-22     EC 3.1.18

External Ids:    HGNC: 187171   Entrez Gene: 110572   Ensembl: ENSG000001405267   OMIM: 6121965   UniProtKB: P089103   

Export aliases for ABHD2 gene to outside databases

Previous GC identifers: GC15P085970 GC15P082997 GC15P087218 GC15P087361 GC15P087432 GC15P065743


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ABHD2 Gene:
This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very
wide range of enzymes. The function of this protein has not been determined. Alternative splicing of this gene
results in two transcript variants encoding the same protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for ABHD2 Gene:
ABHD2 (abhydrolase domain containing 2) is a protein-coding gene. GO annotations related to this gene include . An important paralog of this gene is ABHD1.

UniProtKB/Swiss-Prot: ABHD2_HUMAN, P08910
Function: May play a role in smooth muscle cells migration (By similarity)

Gene Wiki entry for ABHD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ABHD2 gene promoter:
         RFX1   GATA-3   Pax-2   Pax-2a   Nkx2-5   HNF-3beta   FOXL1   C/EBPalpha   MEF-2A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidABHD2 promoter sequence
   Search Chromatin IP Primers for ABHD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ABHD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

ABHD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABHD2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P089631:  view genomic region     (about GC identifiers)

Start:
89,630,690 bp from pter      End:
89,745,591 bp from pter
Size:
114,902 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ABHD2_HUMAN, P08910 (See protein sequence)
Recommended Name: Abhydrolase domain-containing protein 2  
Size: 425 amino acids; 48315 Da
Caution: Was originally (PubMed:2843827) thought to be a G-coupled receptor
Secondary accessions: Q53G48 Q53GU0 Q5FVD9 Q8TC79

Explore the universe of human proteins at neXtProt for ABHD2: NX_P08910

Explore proteomics data for ABHD2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys36, Lys57, Lys152
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ABHD2 (P08910) (see all 13)
     PLTWMDK  ICPGIAN  QWDQCRR  TMVICPGI 


    See ABHD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_008942.3  NP_690888.1  

    ENSEMBL proteins: 
     ENSP00000457882   ENSP00000268129   ENSP00000454645   ENSP00000454531   ENSP00000455639  
     ENSP00000347217  

    ABHD2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ABHD2

     
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    antibodies-online peptides for ABHD2

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    antibodies-online antibodies for ABHD2 (21 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ABHD: Abhydrolase domain containing

    3 InterPro protein domains:
     IPR000952 UPF0017_hydro-like_CS
     IPR000073 AB_hydrolase_1
     IPR012020 AB-Hydro_YheT

    Graphical View of Domain Structure for InterPro Entry P08910

    ProtoNet protein and cluster: P08910

    1 Blocks protein domain: IPB000952 Protein of unknown function UPF0017

    UniProtKB/Swiss-Prot: ABHD2_HUMAN, P08910
    Similarity: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family


    Find genes that share domains with ABHD2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ABHD2_HUMAN, P08910
    Function: May play a role in smooth muscle cells migration (By similarity)

         Enzyme Numbers (IUBMB): EC 3.1.12 EC 3.1.1.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0016787hydrolase activity IEA--
         
    Find genes that share ontologies with ABHD2           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Abhd2):
     cardiovascular system  cellular  homeostasis/metabolism 

    Find genes that share phenotypes with ABHD2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ABHD2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ABHD2:
    hsa-mir-335-5p (MIRT018354), hsa-mir-16-5p (MIRT051282), hsa-mir-92a-3p (MIRT049598), hsa-mir-484 (MIRT041909)

    Block miRNA regulation of human, mouse, rat ABHD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ABHD2 (see all 129):
    hsa-miR-576-3p hsa-miR-106a hsa-miR-605 hsa-miR-519a hsa-miR-298 hsa-miR-3116 hsa-miR-761 hsa-miR-4273
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABHD2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ABHD2_HUMAN, P08910: Membrane; Single-pass type II membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with ABHD2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including ABHD2: 
              Cardiotoxicity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ABHD2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for ABHD2 (P089103 ENSP000002681294) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    QKIQ96PU83I2D: score=3 
    UBCENSP000003448184STRING: ENSP00000344818
    YIPF1ENSP000000726444STRING: ENSP00000072644
    YIPF2ENSP000002530314STRING: ENSP00000253031
    --ENSP000002597374STRING: ENSP00000259737
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0009611response to wounding IEA--
    GO:0030336negative regulation of cell migration IEA--

    Find genes that share ontologies with ABHD2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ABHD2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ABHD2 gene (2 alternative transcripts): 
    NM_007011.7  NM_152924.4  

    Unigene Cluster for ABHD2:

    Abhydrolase domain containing 2
    Hs.122337  [show with all ESTs]
    Unigene Representative Sequence: NM_007011
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000569411 ENST00000352732(uc010ups.1 uc002bnj.2 uc002bnk.2)
    ENST00000564876 ENST00000569550 ENST00000565066 ENST00000565973 ENST00000565825
    ENST00000562254 ENST00000562073 ENST00000568308 ENST00000355100
    miRNA
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    Block miRNA regulation of human, mouse, rat ABHD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ABHD2 (see all 129):
    hsa-miR-576-3p hsa-miR-106a hsa-miR-605 hsa-miR-519a hsa-miR-298 hsa-miR-3116 hsa-miR-761 hsa-miR-4273
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): ABHD2 (NM_007011)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABHD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABHD2
    Primer
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    OriGene qPCR primer pairs and template standards for ABHD2
    OriGene qSTAR qPCR primer pairs in human, mouse for ABHD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ABHD2
      QuantiTect SYBR Green Assays in human, mouse, rat ABHD2
      QuantiFast Probe-based Assays in human, mouse, rat ABHD2

    Additional mRNA sequence: 

    AF546700.1 AK000554.1 AK095685.1 AK125089.1 AK127559.1 AK222841.1 AK223083.1 AK290340.1 
    AK296827.1 AL109729.1 AL110291.1 BC017905.1 BC019248.1 BC090052.1 CR749694.1 X12433.1 

    23 DOTS entries:

    DT.111436  DT.100773430  DT.75154841  DT.121023777  DT.75116799  DT.75180885  DT.100787324  DT.95218109 
    DT.95347582  DT.100787320  DT.95336838  DT.97835776  DT.100672525  DT.121023794  DT.121023799  DT.121023806 
    DT.121023926  DT.40205643  DT.92465201  DT.100774341  DT.121643720  DT.91898293  DT.95168871 

    Selected AceView cDNA sequences (see all 372):

    BQ718372 AA435680 AA844911 AW471335 AW026912 BE218573 AI623890 BM768679 
    BQ000491 CB528640 BM756704 BU623852 F08975 CA428158 AA350195 BQ882196 
    CA423311 AA595339 AI682705 BQ688848 BX097782 AW300955 AI270689 NM_152924 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ABHD2 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^
    SP1:                                                        -                                                                 -                             -   
    SP2:                                -     -     -     -     -                                                                 -                             -   
    SP3:                                      -           -     -                                                                                                   
    SP4:                                -     -                 -                                                                                                   
    SP5:                                                                                                                                                            

    ExUns: 17
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for ABHD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ABHD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGTTTTGCC
    ABHD2 Expression
    About this image


    ABHD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
     
     Adipose (Muscoskeletal System)
             White adipocyte-like cells
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Brain (Nervous System)
             Choroid Plexus
     
     Lung (Respiratory System)
    ABHD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ABHD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.122337
        Pathway & Disease-focused RT2 Profiler PCR Array including ABHD2: 
              Cardiotoxicity in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABHD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ABHD2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Abhd21 , 5 abhydrolase domain containing 21, 5 91.53(n)1
    98.82(a)1
      7 (44.96 cM)5
    546081  NM_018811.61  NP_061281.31 
     792732015 
    chicken
    (Gallus gallus)
    Aves ABHD21 abhydrolase domain containing 2 80.47(n)
    89.88(a)
      415493  XM_004943844.1  XP_004943901.1 
    lizard
    (Anolis carolinensis)
    Reptilia ABHD26
    abhydrolase domain containing 2
    87(a)
    1 ↔ 1
    GL343444.1(144814-174181)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia abhd21 abhydrolase domain containing 2 73.84(n)
    82.51(a)
      100216078  NM_001142063.1  NP_001135535.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc557222 similar to abhydrolase domain containing 2 75.3(n)   393888  BC047183.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hydr21 alpha/beta hydrolase2 53.54(n)
    44.36(a)
      33532  NM_134907.4  NP_608751.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes --
    EHT16
    (see all 3)
    Putative acyltransferase with similarity to Eeb1p ...
    Acyl-coenzymeA:ethanol O-acyltransferase that play...
    (see all 3)
    18(a)
    17(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    XIII(687516-688865) YMR210W
    II(584807-586162) YBR177C


    ENSEMBL Gene Tree for ABHD2 (if available)
    TreeFam Gene Tree for ABHD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ABHD2 gene
    ABHD12  ABHD32  ABHD152  

    Find genes that share paralogs with ABHD2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ABHD2 (see all 2574)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2006607791,2
    --89629432(+) TTGTA-/TTTTTT 2 -- us2k10--------
    rs344532461,2
    C,F--89629594(+) ACAAAA/GTTTGT 2 -- us2k13Minor allele frequency- G:0.16NA 124
    rs1807179661,2
    --89629846(+) TCACTA/CTGTTG 2 -- us2k10--------
    rs1872720191,2
    --89629857(+) CCCAGA/GTTGGT 2 -- us2k10--------
    rs1921751491,2
    --89629913(+) CAGGCA/GTGAGC 2 -- us2k10--------
    rs1837849671,2
    --89629918(+) GTGAGC/TCACTG 2 -- us2k10--------
    rs786206801,2
    C,F--89629968(+) AGCTAC/TACCAA 2 -- us2k12Minor allele frequency- T:0.04WA EA 238
    rs1862519531,2
    --89629999(+) CCTTAC/TATACT 2 -- us2k10--------
    rs1906207131,2
    --89630167(+) TGAAAA/CCTTTT 2 -- us2k10--------
    rs1166264331,2
    F--89630169(+) AAACCT/ATTTTT 2 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for ABHD2 (89630690 - 89745591 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ABHD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv507795CNV Insertion20534489
    nsv523275CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ABHD2
    DNA2.0 Custom Variant and Variant Library Synthesis for ABHD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612196    OMIM disorders: --


    Find genes that share disorders with ABHD2           About GenesLikeMe


    Export disorders for ABHD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ABHD2 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with ABHD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Primary structure of a human protein which bears structural similarities to members of the rhodopsin/beta-adrenergic receptor family. (PubMed id 2843827)1, 2 Rapiejko P.J.... Malbon C.C. (Nucleic Acids Res. 1988)
    3. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    9. Allele *1 of HS1.2 enhancer associates with selective IgA deficiency and IgM concentration. (PubMed id 20007591)1 Giambra V....Frezza D. (J. Immunol. 2009)
    10. Elevated mature macrophage expression of human ABHD2 gene in vulnerable plaque. (PubMed id 17980156)1 Miyata K....Yamamura K. (Biochem. Biophys. Res. Commun. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11057 HGNC: 18717 AceView: ABHD2 Ensembl:ENSG00000140526 euGenes: HUgn11057
    ECgene: ABHD2 H-InvDB: ABHD2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ABHD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ABHD2 gene:
    Search GeneIP for patents involving ABHD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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