Aliases for ABHD2 Gene
External Ids for ABHD2 Gene
Previous GeneCards Identifiers for ABHD2 Gene
This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of enzymes. The function of this protein has not been determined. Alternative splicing of this gene results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for ABHD2 Gene
ABHD2 (Abhydrolase Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include carboxylic ester hydrolase activity. An important paralog of this gene is ABHD3.
UniProtKB/Swiss-Prot for ABHD2 Gene
Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity).