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Aliases for ABHD2 Gene

Aliases for ABHD2 Gene

  • Abhydrolase Domain Containing 2 2 3 5
  • Abhydrolase Domain-Containing Protein 2 3 4
  • 2-Arachidonoylglycerol Hydrolase 3 4
  • Lung Alpha/Beta Hydrolase 2 3 4
  • Protein PHPS1-2 3 4
  • LABH2 3 4
  • Alpha/Beta Hydrolase Domain Containing Protein 2 3
  • Testicular Tissue Protein Li 6 3
  • Monoacylglycerol Lipase ABHD2 3
  • EC 3.1.1.23 4
  • EC 3.1.1 61
  • PHPS1-2 3
  • HS1-2 3

External Ids for ABHD2 Gene

Previous GeneCards Identifiers for ABHD2 Gene

  • GC15P085970
  • GC15P082997
  • GC15P087218
  • GC15P087361
  • GC15P087432
  • GC15P089631
  • GC15P065743

Summaries for ABHD2 Gene

Entrez Gene Summary for ABHD2 Gene

  • This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of enzymes. The function of this protein has not been determined. Alternative splicing of this gene results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABHD2 Gene

ABHD2 (Abhydrolase Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include carboxylic ester hydrolase activity. An important paralog of this gene is ABHD3.

UniProtKB/Swiss-Prot for ABHD2 Gene

  • Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity).

Gene Wiki entry for ABHD2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD2 Gene

Genomics for ABHD2 Gene

Regulatory Elements for ABHD2 Gene

Enhancers for ABHD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F089124 1.3 FANTOM5 Ensembl ENCODE 37.7 +45.6 45620 16.2 HDGF PKNOX1 ZFP64 ARID4B FEZF1 DMAP1 YBX1 ZNF2 YY1 FOS ABHD2 LOC102724566 DET1 ISG20 GC15M089136 RNU7-195P
GH15F089164 0.9 Ensembl ENCODE 12.6 +79.5 79512 4.9 SIN3A THRB RAD21 RARA EGR1 ZNF366 SCRT2 ETV6 FOS CREM ABHD2 RNU7-195P FANCI POLG PIR48171 GC15P089156
GH15F089171 0.5 ENCODE 12.6 +84.2 84176 0.2 GATAD2A SCRT1 ELF3 CTCF ZNF654 FOXA3 ARID4B REST ZNF2 RAD21 ABHD2 RNU7-195P RLBP1 FANCI PIR48171 GC15P089156
GH15F089110 1 Ensembl ENCODE 11.8 +29.8 29795 13.5 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 FOS SP3 SP5 JUNB ABHD2 LOC102724566 RNU7-195P GC15M089095
GH15F089040 0.7 Ensembl 11.8 -46.2 -46238 0.8 ZNF133 INSM2 GLI4 ZNF664 POLR2A PRDM10 ZNF600 FOS ZBTB20 THAP11 ABHD2 HAPLN3 RLBP1 FANCI LOC102724566 GC15M089074
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ABHD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ABHD2 Gene

Chromosome:
15
Start:
89,087,459 bp from pter
End:
89,202,360 bp from pter
Size:
114,902 bases
Orientation:
Plus strand

Genomic View for ABHD2 Gene

Genes around ABHD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABHD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABHD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD2 Gene

Proteins for ABHD2 Gene

  • Protein details for ABHD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08910-ABHD2_HUMAN
    Recommended name:
    Monoacylglycerol lipase ABHD2
    Protein Accession:
    P08910
    Secondary Accessions:
    • Q53G48
    • Q53GU0
    • Q5FVD9
    • Q8TC79

    Protein attributes for ABHD2 Gene

    Size:
    425 amino acids
    Molecular mass:
    48315 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ABHD2 Gene

Post-translational modifications for ABHD2 Gene

  • Ubiquitination at Lys 36, Lys 57, and Lys 152
  • Modification sites at PhosphoSitePlus

Domains & Families for ABHD2 Gene

Gene Families for ABHD2 Gene

Protein Domains for ABHD2 Gene

Suggested Antigen Peptide Sequences for ABHD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08910

UniProtKB/Swiss-Prot:

ABHD2_HUMAN :
  • Contains 1 AB hydrolase-1 (Alpha/Beta hydrolase fold 1) domain.
  • Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.
Domain:
  • Contains 1 AB hydrolase-1 (Alpha/Beta hydrolase fold 1) domain.
Family:
  • Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.
genes like me logo Genes that share domains with ABHD2: view

Function for ABHD2 Gene

Molecular function for ABHD2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolyzes glycerol monoesters of long-chain fatty acids.
UniProtKB/Swiss-Prot EnzymeRegulation:
Acylglycerol lipase activity is activated upon binding to progesterone.
UniProtKB/Swiss-Prot Function:
Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity).

Enzyme Numbers (IUBMB) for ABHD2 Gene

Gene Ontology (GO) - Molecular Function for ABHD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003707 steroid hormone receptor activity IDA 26989199
GO:0016787 hydrolase activity IEA --
GO:0042562 hormone binding IDA 26989199
GO:0047372 acylglycerol lipase activity IEA,IDA 26989199
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with ABHD2: view
genes like me logo Genes that share phenotypes with ABHD2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ABHD2

miRNA for ABHD2 Gene

miRTarBase miRNAs that target ABHD2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABHD2 Gene

Localization for ABHD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABHD2 Gene

Cell projection, cilium, flagellum membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABHD2 Gene COMPARTMENTS Subcellular localization image for ABHD2 gene
Compartment Confidence
extracellular 3
nucleus 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ABHD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0036126 sperm flagellum IDA 26989199
genes like me logo Genes that share ontologies with ABHD2: view

Pathways & Interactions for ABHD2 Gene

SuperPathways for ABHD2 Gene

No Data Available

Interacting Proteins for ABHD2 Gene

Gene Ontology (GO) - Biological Process for ABHD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0007340 acrosome reaction IEA --
GO:0009611 response to wounding IEA --
GO:0016042 lipid catabolic process IEA --
GO:0030336 negative regulation of cell migration IEA --
genes like me logo Genes that share ontologies with ABHD2: view

No data available for Pathways by source and SIGNOR curated interactions for ABHD2 Gene

Transcripts for ABHD2 Gene

Unigene Clusters for ABHD2 Gene

Abhydrolase domain containing 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^
SP1: - - -
SP2: - - - - - - -
SP3: - - -
SP4: - - -
SP5:
SP6:
SP7: - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - -
SP10: - - - -
SP11: - - - -

ExUns: 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ABHD2 Gene

GeneLoc Exon Structure for
ABHD2
ECgene alternative splicing isoforms for
ABHD2

Expression for ABHD2 Gene

mRNA expression in normal human tissues for ABHD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABHD2 Gene

This gene is overexpressed in Liver (x4.1).

Protein differential expression in normal tissues from HIPED for ABHD2 Gene

This gene is overexpressed in Heart (41.4) and Liver (24.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABHD2 Gene



Protein tissue co-expression partners for ABHD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ABHD2 Gene:

ABHD2

SOURCE GeneReport for Unigene cluster for ABHD2 Gene:

Hs.122337

mRNA Expression by UniProt/SwissProt for ABHD2 Gene:

P08910-ABHD2_HUMAN
Tissue specificity: Present in sperm (at protein level).
genes like me logo Genes that share expression patterns with ABHD2: view

Primer Products

Orthologs for ABHD2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ABHD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABHD2 34 35
  • 99.53 (n)
oppossum
(Monodelphis domestica)
Mammalia ABHD2 35
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 93 (a)
OneToMany
-- 35
  • 90 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ABHD2 34 35
  • 92.16 (n)
cow
(Bos Taurus)
Mammalia ABHD2 34 35
  • 92 (n)
mouse
(Mus musculus)
Mammalia Abhd2 34 16 35
  • 91.53 (n)
rat
(Rattus norvegicus)
Mammalia Abhd2 34
  • 91.06 (n)
chicken
(Gallus gallus)
Aves ABHD2 34 35
  • 80.47 (n)
lizard
(Anolis carolinensis)
Reptilia ABHD2 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd2 34
  • 73.84 (n)
zebrafish
(Danio rerio)
Actinopterygii abhd2b 35
  • 76 (a)
OneToMany
abhd2a 35
  • 75 (a)
OneToMany
zgc55722 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5024 34
fruit fly
(Drosophila melanogaster)
Insecta Hydr2 34 35
  • 53.54 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008542 34
  • 50.36 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 18 (a)
ManyToMany
EEB1 35
  • 17 (a)
ManyToMany
EHT1 35
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9408 35
  • 42 (a)
OneToOne
Species where no ortholog for ABHD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABHD2 Gene

ENSEMBL:
Gene Tree for ABHD2 (if available)
TreeFam:
Gene Tree for ABHD2 (if available)

Paralogs for ABHD2 Gene

Paralogs for ABHD2 Gene

genes like me logo Genes that share paralogs with ABHD2: view

Variants for ABHD2 Gene

Sequence variations from dbSNP and Humsavar for ABHD2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1005398 -- 89,176,144(-) ATGCA(A/G)ACAAA intron-variant
rs1005399 -- 89,175,682(-) TATAC(A/G)TGTGT intron-variant
rs1009659 -- 89,184,207(+) ACGAC(A/G)TTGTG intron-variant
rs1009660 -- 89,184,226(+) TTGTC(A/G)CTCCA intron-variant
rs10152665 -- 89,182,905(+) AAATT(A/G)AACCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABHD2 Gene

Variant ID Type Subtype PubMed ID
dgv459e214 CNV gain 21293372
esv3637182 CNV loss 21293372
nsv1038140 CNV gain 25217958
nsv1050740 CNV loss 25217958
nsv473088 CNV novel sequence insertion 20440878
nsv507795 OTHER sequence alteration 20534489
nsv523275 CNV loss 19592680
nsv977755 CNV duplication 23825009

Variation tolerance for ABHD2 Gene

Residual Variation Intolerance Score: 23.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABHD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABHD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABHD2 Gene

Disorders for ABHD2 Gene

Relevant External Links for ABHD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABHD2

No disorders were found for ABHD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABHD2 Gene

Publications for ABHD2 Gene

  1. Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone. (PMID: 26989199) Miller M.R. … Lishko P.V. (Science 2016) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Primary structure of a human protein which bears structural similarities to members of the rhodopsin/beta-adrenergic receptor family. (PMID: 2843827) Rapiejko P.J. … Malbon C.C. (Nucleic Acids Res. 1988) 3 4 64
  4. Associations of ABHD2 genetic variations with risks for chronic obstructive pulmonary disease in a Chinese Han population. (PMID: 25880496) Liu L. … Jin S. (PLoS ONE 2015) 3 64
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 64

Products for ABHD2 Gene

Sources for ABHD2 Gene

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