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Aliases for ABHD17C Gene

Aliases for ABHD17C Gene

  • Abhydrolase Domain Containing 17C 2 3 5
  • Alpha/Beta Hydrolase Domain-Containing Protein 17C 3 4
  • Family With Sequence Similarity 108, Member C1 2 3
  • Abhydrolase Domain-Containing Protein 17C 3 4
  • FAM108C1 3 4
  • Abhydrolase Domain-Containing Protein FAM108C1 3
  • Protein ABHD17C 3
  • EC 3.-.-.- 4

External Ids for ABHD17C Gene

Previous HGNC Symbols for ABHD17C Gene

  • FAM108C1

Previous GeneCards Identifiers for ABHD17C Gene

  • GC15P080972

Summaries for ABHD17C Gene

GeneCards Summary for ABHD17C Gene

ABHD17C (Abhydrolase Domain Containing 17C) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity and serine-type peptidase activity. An important paralog of this gene is ABHD17A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD17C Gene

Genomics for ABHD17C Gene

Regulatory Elements for ABHD17C Gene

Enhancers for ABHD17C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F080620 0.4 ENCODE 12 -58.9 -58860 0.9 GATAD2A SOX5 SOX13 ZNF792 FOXA3 JUN NR2F2 ZNF316 MAFK EMSY ABHD17C RNU6-380P CEMIP ARNT2 MIR5572 GC15P080662 ENSG00000270919
GH15F080701 0.2 ENCODE 11 +22.5 22528 0.8 OSR2 ZNF121 SCRT2 ABHD17C PIR33016 CEMIP
GH15F080726 0.5 ENCODE 10.1 +47.8 47767 2.2 NFE2 CEMIP ABHD17C PIR33016
GH15F080776 0.9 FANTOM5 ENCODE 6.5 +98.3 98257 3.2 PKNOX1 WRNIP1 ARID4B SIN3A ZNF48 GLIS2 ELK1 ZNF143 FOS SP3 CEMIP MESDC1 ABHD17C PIR33016
GH15F080708 1.1 ENCODE 6 +30.3 30338 2.4 PKNOX1 CREB3L1 SIN3A FEZF1 YY1 ZNF121 ZNF335 ZNF766 ETV6 KLF13 CEMIP RNU6-380P ABHD17C PIR33016
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ABHD17C on UCSC Golden Path with GeneCards custom track

Genomic Location for ABHD17C Gene

Chromosome:
15
Start:
80,679,684 bp from pter
End:
80,755,621 bp from pter
Size:
75,938 bases
Orientation:
Plus strand

Genomic View for ABHD17C Gene

Genes around ABHD17C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABHD17C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABHD17C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD17C Gene

Proteins for ABHD17C Gene

  • Protein details for ABHD17C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PCB6-AB17C_HUMAN
    Recommended name:
    Protein ABHD17C
    Protein Accession:
    Q6PCB6
    Secondary Accessions:
    • Q1RMD6
    • Q9NPM1

    Protein attributes for ABHD17C Gene

    Size:
    329 amino acids
    Molecular mass:
    35831 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABHD17C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABHD17C Gene

Post-translational modifications for ABHD17C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ABHD17C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ABHD17C Gene

Domains & Families for ABHD17C Gene

Gene Families for ABHD17C Gene

Protein Domains for ABHD17C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ABHD17C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PCB6

UniProtKB/Swiss-Prot:

AB17C_HUMAN :
  • Belongs to the AB hydrolase superfamily. ABHD17 family.
Family:
  • Belongs to the AB hydrolase superfamily. ABHD17 family.
genes like me logo Genes that share domains with ABHD17C: view

Function for ABHD17C Gene

Enzyme Numbers (IUBMB) for ABHD17C Gene

Gene Ontology (GO) - Molecular Function for ABHD17C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ABHD17C: view

Phenotypes for ABHD17C Gene

genes like me logo Genes that share phenotypes with ABHD17C: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABHD17C Gene

Localization for ABHD17C Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ABHD17C Gene

Pathways & Interactions for ABHD17C Gene

SuperPathways for ABHD17C Gene

No Data Available

Interacting Proteins for ABHD17C Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000258884%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000258884 Q6PCB6-AB17C_HUMAN for ABHD17C Gene via STRING IID

Gene Ontology (GO) - Biological Process for ABHD17C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ABHD17C Gene

Transcripts for ABHD17C Gene

Unigene Clusters for ABHD17C Gene

Abhydrolase domain containing 17C:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD17C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1:
SP2: - -
SP3: - - -
SP4: - - -

Relevant External Links for ABHD17C Gene

GeneLoc Exon Structure for
ABHD17C
ECgene alternative splicing isoforms for
ABHD17C

Expression for ABHD17C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ABHD17C Gene

mRNA differential expression in normal tissues according to GTEx for ABHD17C Gene

This gene is overexpressed in Colon - Transverse (x4.4) and Esophagus - Mucosa (x4.3).

Protein differential expression in normal tissues from HIPED for ABHD17C Gene

This gene is overexpressed in Bone (24.5), Peripheral blood mononuclear cells (13.0), and Heart (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABHD17C Gene



Protein tissue co-expression partners for ABHD17C Gene

NURSA nuclear receptor signaling pathways regulating expression of ABHD17C Gene:

ABHD17C

SOURCE GeneReport for Unigene cluster for ABHD17C Gene:

Hs.459072
genes like me logo Genes that share expression patterns with ABHD17C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ABHD17C Gene

Orthologs for ABHD17C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABHD17C Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ABHD17C 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ABHD17C 34 35
  • 92.2 (n)
mouse
(Mus musculus)
Mammalia Abhd17c 34 16 35
  • 90.52 (n)
chimpanzee
(Pan troglodytes)
Mammalia FAM108C1 34
  • 90.15 (n)
ABHD17C 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abhd17c 34
  • 89.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ABHD17C 35
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABHD17C 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves ABHD17C 34 35
  • 85.31 (n)
lizard
(Anolis carolinensis)
Reptilia ABHD17C 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd17c 34
  • 78.71 (n)
Str.1269 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6584 34
zebrafish
(Danio rerio)
Actinopterygii abhd17c 34 35
  • 79.93 (n)
zgc55468 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10703 34
fruit fly
(Drosophila melanogaster)
Insecta CG33096 34 35
  • 67.96 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010402 34
  • 65.86 (n)
worm
(Caenorhabditis elegans)
Secernentea aho-3 34
  • 57.98 (n)
Y41E3.18 35
  • 22 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 21 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G31020 34
  • 52.62 (n)
rice
(Oryza sativa)
Liliopsida Os02g0796600 34
  • 57.1 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.30013 34
corn
(Zea mays)
Liliopsida Zm.1574 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8399 35
  • 73 (a)
OneToMany
Species where no ortholog for ABHD17C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ABHD17C Gene

ENSEMBL:
Gene Tree for ABHD17C (if available)
TreeFam:
Gene Tree for ABHD17C (if available)

Paralogs for ABHD17C Gene

Paralogs for ABHD17C Gene

(2) SIMAP similar genes for ABHD17C Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ABHD17C Gene

genes like me logo Genes that share paralogs with ABHD17C: view

Variants for ABHD17C Gene

Sequence variations from dbSNP and Humsavar for ABHD17C Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1046417 -- 80,755,063(+) CTGAC(C/T)TTCCT utr-variant-3-prime
rs10519290 -- 80,707,001(+) ACTGG(A/T)TAAAA intron-variant
rs10523879 -- 80,705,333(+) TGATT(-/TGTGTGTGTG/TGTGTGTGTGTGTGTGTGTGTGTGTG/TTTGTGTG)TGTGT intron-variant
rs10572505 -- 80,726,527(+) TTTTT(-/TTT)GAGAC intron-variant
rs10644616 -- 80,717,271(+) AAAAA(-/AAC/AC/C)GAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABHD17C Gene

Variant ID Type Subtype PubMed ID
esv3569764 CNV gain 25503493
nsv1070286 CNV deletion 25765185
nsv1118325 CNV deletion 24896259
nsv471685 CNV gain 15918152
nsv952008 CNV duplication 24416366

Variation tolerance for ABHD17C Gene

Residual Variation Intolerance Score: 32.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABHD17C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABHD17C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABHD17C Gene

Disorders for ABHD17C Gene

Relevant External Links for ABHD17C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABHD17C

No disorders were found for ABHD17C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABHD17C Gene

Publications for ABHD17C Gene

  1. Genome-wide association study of antibody response to smallpox vaccine. (PMID: 22542470) Ovsyannikova I.G. … Poland G.A. (Vaccine 2012) 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for ABHD17C Gene

Sources for ABHD17C Gene

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