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Aliases for ABHD17C Gene

Aliases for ABHD17C Gene

  • Abhydrolase Domain Containing 17C 2 3 5
  • Alpha/Beta Hydrolase Domain-Containing Protein 17C 3 4
  • Family With Sequence Similarity 108, Member C1 2 3
  • Abhydrolase Domain-Containing Protein 17C 3 4
  • FAM108C1 3 4
  • Abhydrolase Domain-Containing Protein FAM108C1 3
  • EC 3.-.-.- 4

External Ids for ABHD17C Gene

Previous HGNC Symbols for ABHD17C Gene

  • FAM108C1

Previous GeneCards Identifiers for ABHD17C Gene

  • GC15P080972

Summaries for ABHD17C Gene

GeneCards Summary for ABHD17C Gene

ABHD17C (Abhydrolase Domain Containing 17C) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity and serine-type peptidase activity. An important paralog of this gene is ABHD17B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD17C Gene

Genomics for ABHD17C Gene

Genomic Location for ABHD17C Gene

Chromosome:
15
Start:
80,679,684 bp from pter
End:
80,755,621 bp from pter
Size:
75,938 bases
Orientation:
Plus strand

Genomic View for ABHD17C Gene

Genes around ABHD17C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABHD17C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABHD17C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD17C Gene

No data available for Regulatory Elements for ABHD17C Gene

Proteins for ABHD17C Gene

  • Protein details for ABHD17C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PCB6-AB17C_HUMAN
    Recommended name:
    Protein ABHD17C
    Protein Accession:
    Q6PCB6
    Secondary Accessions:
    • Q1RMD6
    • Q9NPM1

    Protein attributes for ABHD17C Gene

    Size:
    329 amino acids
    Molecular mass:
    35831 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABHD17C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABHD17C Gene

Proteomics data for ABHD17C Gene at MOPED

Post-translational modifications for ABHD17C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ABHD17C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ABHD17C Gene

Domains & Families for ABHD17C Gene

Gene Families for ABHD17C Gene

Protein Domains for ABHD17C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ABHD17C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PCB6

UniProtKB/Swiss-Prot:

AB17C_HUMAN :
  • Belongs to the AB hydrolase superfamily. ABHD17 family.
Family:
  • Belongs to the AB hydrolase superfamily. ABHD17 family.
genes like me logo Genes that share domains with ABHD17C: view

Function for ABHD17C Gene

Enzyme Numbers (IUBMB) for ABHD17C Gene

Phenotypes for ABHD17C Gene

GenomeRNAi human phenotypes for ABHD17C:
genes like me logo Genes that share phenotypes with ABHD17C: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABHD17C Gene

Localization for ABHD17C Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ABHD17C Gene

Pathways & Interactions for ABHD17C Gene

SuperPathways for ABHD17C Gene

No Data Available

Interacting Proteins for ABHD17C Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000258884%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q6PCB6-AB17C_HUMAN ENSP00000258884 for ABHD17C Gene via I2D STRING

Gene Ontology (GO) - Biological Process for ABHD17C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ABHD17C Gene

Drugs & Compounds for ABHD17C Gene

No Compound Related Data Available

Transcripts for ABHD17C Gene

Unigene Clusters for ABHD17C Gene

Abhydrolase domain containing 17C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD17C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1:
SP2: - -
SP3: - - -
SP4: - - -

Relevant External Links for ABHD17C Gene

GeneLoc Exon Structure for
ABHD17C
ECgene alternative splicing isoforms for
ABHD17C

Expression for ABHD17C Gene

mRNA expression in normal human tissues for ABHD17C Gene

mRNA differential expression in normal tissues according to GTEx for ABHD17C Gene

This gene is overexpressed in Colon - Transverse (x4.4) and Esophagus - Mucosa (x4.3).

Protein differential expression in normal tissues from HIPED for ABHD17C Gene

This gene is overexpressed in Bone (24.5), Peripheral blood mononuclear cells (13.0), and Heart (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ABHD17C Gene



SOURCE GeneReport for Unigene cluster for ABHD17C Gene Hs.459072

genes like me logo Genes that share expression patterns with ABHD17C: view

Protein tissue co-expression partners for ABHD17C Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ABHD17C Gene

Orthologs for ABHD17C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABHD17C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ABHD17C 35
  • 92.2 (n)
  • 94.83 (a)
ABHD17C 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abhd17c 35
  • 90.52 (n)
  • 95.31 (a)
Abhd17c 16
Abhd17c 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM108C1 35
  • 90.15 (n)
  • 90.25 (a)
ABHD17C 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abhd17c 35
  • 89.48 (n)
  • 95.31 (a)
dog
(Canis familiaris)
Mammalia ABHD17C 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABHD17C 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABHD17C 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves ABHD17C 35
  • 85.31 (n)
  • 95.72 (a)
ABHD17C 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABHD17C 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd17c 35
  • 78.71 (n)
  • 90.97 (a)
Str.1269 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6584 35
zebrafish
(Danio rerio)
Actinopterygii abhd17c 35
  • 79.93 (n)
  • 89.46 (a)
zgc55468 35
abhd17c 36
  • 89 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10703 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010402 35
  • 65.86 (n)
  • 76.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33096 35
  • 67.96 (n)
  • 69.96 (a)
CG33096 36
  • 70 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea aho-3 35
  • 57.98 (n)
  • 63.03 (a)
Y41E3.18 36
  • 22 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 21 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G31020 35
  • 52.62 (n)
  • 49.61 (a)
rice
(Oryza sativa)
Liliopsida Os02g0796600 35
  • 57.1 (n)
  • 51.39 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.30013 35
corn
(Zea mays)
Liliopsida Zm.1574 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8399 36
  • 73 (a)
OneToMany
Species with no ortholog for ABHD17C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ABHD17C Gene

ENSEMBL:
Gene Tree for ABHD17C (if available)
TreeFam:
Gene Tree for ABHD17C (if available)

Paralogs for ABHD17C Gene

Paralogs for ABHD17C Gene

(2) SIMAP similar genes for ABHD17C Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ABHD17C Gene

genes like me logo Genes that share paralogs with ABHD17C: view

Variants for ABHD17C Gene

Sequence variations from dbSNP and Humsavar for ABHD17C Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs958091 -- 80,732,026(+) ACATT(A/T)AAAGT intron-variant
rs960170 -- 80,731,835(+) ATTTA(A/G)GAGGA intron-variant
rs967839 -- 80,727,564(-) CCTCT(A/G)GGAAA intron-variant
rs972480 -- 80,734,710(-) AAGAA(C/T)GTAAT intron-variant
rs972481 -- 80,734,584(-) TTTTA(C/T)CTTCC intron-variant

Variation tolerance for ABHD17C Gene

Residual Variation Intolerance Score: 32.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABHD17C Gene

HapMap Linkage Disequilibrium report
ABHD17C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ABHD17C Gene

Disorders for ABHD17C Gene

Relevant External Links for ABHD17C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABHD17C

No disorders were found for ABHD17C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABHD17C Gene

Publications for ABHD17C Gene

  1. Genome-wide association study of antibody response to smallpox vaccine. (PMID: 22542470) Ovsyannikova I.G. … Poland G.A. (Vaccine 2012) 3 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ABHD17C Gene

Sources for ABHD17C Gene

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