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Aliases for ABHD17C Gene

Aliases for ABHD17C Gene

  • Abhydrolase Domain Containing 17C 2 3
  • Family With Sequence Similarity 108, Member C1 2 3
  • FAM108C1 3 4
  • Alpha/Beta Hydrolase Domain-Containing Protein 17C 3
  • Abhydrolase Domain-Containing Protein FAM108C1 3
  • EC 3.-.-.- 4

External Ids for ABHD17C Gene

Previous Symbols for ABHD17C Gene

  • FAM108C1

Summaries for ABHD17C Gene

GeneCards Summary for ABHD17C Gene

ABHD17C (Abhydrolase Domain Containing 17C) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is ABHD17B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD17C Gene

Genomics for ABHD17C Gene

Genomic Location for ABHD17C Gene

Start:
80,679,684 bp from pter
End:
80,755,621 bp from pter
Size:
75,938 bases
Orientation:
Plus strand

Genomic View for ABHD17C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABHD17C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD17C Gene

No data available for Regulatory Elements for ABHD17C Gene

Proteins for ABHD17C Gene

  • Protein details for ABHD17C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PCB6-AB17C_HUMAN
    Recommended name:
    Alpha/beta hydrolase domain-containing protein 17C
    Protein Accession:
    Q6PCB6
    Secondary Accessions:
    • Q1RMD6
    • Q9NPM1

    Protein attributes for ABHD17C Gene

    Size:
    329 amino acids
    Molecular mass:
    35831 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABHD17C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABHD17C Gene

Proteomics data for ABHD17C Gene at MOPED

Post-translational modifications for ABHD17C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ABHD17C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ABHD17C Gene

Domains for ABHD17C Gene

Gene Families for ABHD17C Gene

HGNC:
  • ABHD :Abhydrolase domain containing

Protein Domains for ABHD17C Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

AB17C_HUMAN
Family:
  • Belongs to the AB hydrolase superfamily. ABHD17 family.:
    • Q6PCB6
genes like me logo Genes that share domains with ABHD17C: view

Function for ABHD17C Gene

Enzyme Numbers (IUBMB) for ABHD17C Gene

Gene Ontology (GO) - Molecular Function for ABHD17C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008236 serine-type peptidase activity --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ABHD17C: view

Phenotypes for ABHD17C Gene

GenomeRNAi human phenotypes for ABHD17C:
genes like me logo Genes that share phenotypes with ABHD17C: view

No data available for Molecular function , Animal Models , Transcription Factor Targeting and HOMER Transcription for ABHD17C Gene

Localization for ABHD17C Gene

No data available for Gene Ontology (GO) - Cellular Components for ABHD17C Gene

Pathways for ABHD17C Gene

SuperPathways for ABHD17C Gene

No Data Available

Interacting Proteins for ABHD17C Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000258884%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000258884 Q6PCB6-AB17C_HUMAN for ABHD17C Gene via STRING I2D

Gene Ontology (GO) - Biological Process for ABHD17C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with ABHD17C: view

No data available for Pathways by source for ABHD17C Gene

Transcripts for ABHD17C Gene

Unigene Clusters for ABHD17C Gene

Abhydrolase domain containing 17C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD17C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1:
SP2: - -
SP3: - - -
SP4: - - -

Relevant External Links for ABHD17C Gene

GeneLoc Exon Structure for
ABHD17C
ECgene alternative splicing isoforms for
ABHD17C

Expression for ABHD17C Gene

mRNA expression in normal human tissues for ABHD17C Gene

mRNA differential expression in normal tissues according to GTEx for ABHD17C Gene

This gene is overexpressed in Colon - Transverse (4.4) and Esophagus - Mucosa (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABHD17C Gene

SOURCE GeneReport for Unigene cluster for ABHD17C Gene Hs.459072

genes like me logo Genes that share expressions with ABHD17C: view

Orthologs for ABHD17C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABHD17C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABHD17C 37
  • 89 (a)
OneToOne
FAM108C1 36
  • 90.15 (n)
  • 90.25 (a)
cow
(Bos Taurus)
Mammalia ABHD17C 36
  • 92.2 (n)
  • 94.83 (a)
ABHD17C 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABHD17C 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abhd17c 36
  • 90.52 (n)
  • 95.31 (a)
Abhd17c 37
  • 98 (a)
OneToOne
Fam108c 16
oppossum
(Monodelphis domestica)
Mammalia ABHD17C 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABHD17C 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abhd17c 36
  • 89.48 (n)
  • 95.31 (a)
chicken
(Gallus gallus)
Aves ABHD17C 36
  • 85.31 (n)
  • 95.72 (a)
ABHD17C 37
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABHD17C 37
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6584 36
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd17c 36
  • 78.71 (n)
  • 90.97 (a)
Str.1269 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10703 36
zebrafish
(Danio rerio)
Actinopterygii abhd17c 36
  • 79.93 (n)
  • 89.46 (a)
abhd17c 37
  • 89 (a)
OneToOne
zgc55468 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010402 36
  • 65.86 (n)
  • 76.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33096 36
  • 67.96 (n)
  • 69.96 (a)
CG33096 37
  • 70 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea aho-3 36
  • 57.98 (n)
  • 63.03 (a)
Y41E3.18 37
  • 22 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 21 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G31020 36
  • 52.62 (n)
  • 49.61 (a)
corn
(Zea mays)
Liliopsida Zm.1574 36
rice
(Oryza sativa)
Liliopsida Os02g0796600 36
  • 57.1 (n)
  • 51.39 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.30013 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8399 37
  • 73 (a)
OneToMany
Species with no ortholog for ABHD17C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ABHD17C Gene

ENSEMBL:
Gene Tree for ABHD17C (if available)
TreeFam:
Gene Tree for ABHD17C (if available)

Paralogs for ABHD17C Gene

Paralogs for ABHD17C Gene

Selected SIMAP similar genes for ABHD17C Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ABHD17C Gene

genes like me logo Genes that share paralogs with ABHD17C: view

Variants for ABHD17C Gene

Sequence variations from dbSNP and Humsavar for ABHD17C Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs923000 -- 80,707,660(-) aaccc(G/T)cggcc intron-variant
rs958091 -- 80,732,026(+) ACATT(A/T)AAAGT intron-variant
rs960170 -- 80,731,835(+) ATTTA(A/G)GAGGA intron-variant
rs967839 -- 80,727,564(-) CCTCT(A/G)GGAAA intron-variant
rs972480 -- 80,734,710(-) AAGAA(C/T)GTAAT intron-variant

Relevant External Links for ABHD17C Gene

HapMap Linkage Disequilibrium report
ABHD17C

No data available for Structural Variations from Database of Genomic Variants (DGV) for ABHD17C Gene

Disorders for ABHD17C Gene

No disorders were found for ABHD17C Gene.

No data available for UniProtKB/Swiss-Prot for ABHD17C Gene

Publications for ABHD17C Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3

Products for ABHD17C Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ABHD17C
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ABHD17C
    • Block miRNA regulation of ABHD17C using miScript Target Protectors

    Sources for ABHD17C Gene

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