Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ABHD17B Gene

Aliases for ABHD17B Gene

  • Abhydrolase Domain Containing 17B 2 3 5
  • Alpha/Beta Hydrolase Domain-Containing Protein 17B 3 4
  • Family With Sequence Similarity 108, Member B1 2 3
  • Abhydrolase Domain-Containing Protein 17B 3 4
  • FAM108B1 3 4
  • C9orf77 3 4
  • Abhydrolase Domain-Containing Protein FAM108B1 3
  • Chromosome 9 Open Reading Frame 77 2
  • Protein ABHD17B 3
  • EC 3.-.-.- 4
  • CGI-67 3

External Ids for ABHD17B Gene

Previous HGNC Symbols for ABHD17B Gene

  • C9orf77
  • FAM108B1

Previous GeneCards Identifiers for ABHD17B Gene

  • GC09M074478

Summaries for ABHD17B Gene

GeneCards Summary for ABHD17B Gene

ABHD17B (Abhydrolase Domain Containing 17B) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity and serine-type peptidase activity. An important paralog of this gene is ABHD17A.

Additional gene information for ABHD17B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD17B Gene

Genomics for ABHD17B Gene

Regulatory Elements for ABHD17B Gene

Enhancers for ABHD17B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H071791 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.8 +116.4 116353 6.1 PKNOX1 FOXA2 TBL1XR1 BATF YY1 TEAD3 ETV6 RUNX3 MAFK IKZF2 TMEM2 ABHD17B C9orf85 LOC100420790 GC09P071678
GH09H071806 1 Ensembl ENCODE 10.8 +104.2 104170 0.3 ELF3 CTCF RAD21 RFX5 YY1 GATA3 SMC3 ZNF143 RUNX3 TCF7L2 C9orf85 ABHD17B LOC100420790 TMEM2
GH09H071944 0.7 ENCODE dbSUPER 11.6 -34.1 -34148 2.3 GATA3 STAT1 C9orf85 ABHD17B GC09M071961 PIR47528
GH09H071951 0.7 ENCODE dbSUPER 11 -41.5 -41486 2.2 STAT1 POU5F1 ABHD17B C9orf85 GC09M071961 PIR47528
GH09H071826 0.6 ENCODE 11.4 +84.8 84794 0.2 STAT1 CEBPB DPF2 EP300 FOXA1 ZNF217 GATA3 CTBP1 FOS CUX1 ABHD17B C9orf85 TMEM2 GC09M071903 ENSG00000200922
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ABHD17B on UCSC Golden Path with GeneCards custom track

Promoters for ABHD17B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for ABHD17B Gene

Genomic Locations for ABHD17B Gene
48,782 bases
Minus strand

Genomic View for ABHD17B Gene

Genes around ABHD17B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABHD17B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABHD17B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD17B Gene

Proteins for ABHD17B Gene

  • Protein details for ABHD17B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein ABHD17B
    Protein Accession:
    Secondary Accessions:
    • A8KAJ5
    • Q5VST7
    • Q86YB6
    • Q8IY03
    • Q9Y377

    Protein attributes for ABHD17B Gene

    288 amino acids
    Molecular mass:
    32215 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABHD17B Gene


neXtProt entry for ABHD17B Gene

Post-translational modifications for ABHD17B Gene

  • Ubiquitination at posLast=2525, Lys63, Lys136, and posLast=278278
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ABHD17B Gene

Domains & Families for ABHD17B Gene

Gene Families for ABHD17B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ABHD17B Gene


Suggested Antigen Peptide Sequences for ABHD17B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AB hydrolase superfamily. ABHD17 family.
  • Belongs to the AB hydrolase superfamily. ABHD17 family.
genes like me logo Genes that share domains with ABHD17B: view

Function for ABHD17B Gene

Enzyme Numbers (IUBMB) for ABHD17B Gene

Gene Ontology (GO) - Molecular Function for ABHD17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ABHD17B: view
genes like me logo Genes that share phenotypes with ABHD17B: view

Animal Model Products

Clone Products

No data available for Molecular function , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABHD17B Gene

Localization for ABHD17B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABHD17B Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABHD17B gene
Compartment Confidence
extracellular 4
mitochondrion 1
nucleus 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ABHD17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ABHD17B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ABHD17B Gene

Pathways & Interactions for ABHD17B Gene

SuperPathways for ABHD17B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ABHD17B Gene


No data available for Pathways by source and SIGNOR curated interactions for ABHD17B Gene

Drugs & Compounds for ABHD17B Gene

No Compound Related Data Available

Transcripts for ABHD17B Gene

Unigene Clusters for ABHD17B Gene

Abhydrolase domain containing 17B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD17B Gene

No ASD Table

Relevant External Links for ABHD17B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ABHD17B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ABHD17B Gene

Protein differential expression in normal tissues from HIPED for ABHD17B Gene

This gene is overexpressed in Breast (22.0) and Bone (19.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ABHD17B Gene

NURSA nuclear receptor signaling pathways regulating expression of ABHD17B Gene:


SOURCE GeneReport for Unigene cluster for ABHD17B Gene:


Evidence on tissue expression from TISSUES for ABHD17B Gene

  • Nervous system(4.7)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with ABHD17B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABHD17B Gene

Orthologs for ABHD17B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABHD17B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ABHD17B 34
  • 100 (a)
FAM108B1 33
  • 99.65 (n)
(Canis familiaris)
Mammalia ABHD17B 34
  • 99 (a)
FAM108B1 33
  • 95.6 (n)
(Ornithorhynchus anatinus)
Mammalia ABHD17B 34
  • 99 (a)
(Monodelphis domestica)
Mammalia ABHD17B 34
  • 97 (a)
(Bos Taurus)
Mammalia FAM108B1 34 33
  • 95.14 (n)
(Rattus norvegicus)
Mammalia Abhd17b 33
  • 91.78 (n)
(Mus musculus)
Mammalia Abhd17b 16 34 33
  • 90.97 (n)
(Gallus gallus)
Aves ABHD17B 34 33
  • 87.15 (n)
(Anolis carolinensis)
Reptilia ABHD17B 34
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd17b 33
  • 81.25 (n)
Str.7572 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.30366 33
(Danio rerio)
Actinopterygii abhd17b 34
  • 92 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33096 34
  • 69 (a)
(Caenorhabditis elegans)
Secernentea F01D5.7 34
  • 32 (a)
Y71G12A.4 34
  • 18 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 19 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G13610 33
  • 55.29 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8399 34
  • 70 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.103 33
Species where no ortholog for ABHD17B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABHD17B Gene

Gene Tree for ABHD17B (if available)
Gene Tree for ABHD17B (if available)

Paralogs for ABHD17B Gene

Paralogs for ABHD17B Gene

(2) SIMAP similar genes for ABHD17B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ABHD17B: view

Variants for ABHD17B Gene

Sequence variations from dbSNP and Humsavar for ABHD17B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000038299 -- 71,899,802(+) TCCTA(C/T)GTTAA intron-variant
rs1000112537 -- 71,902,211(+) GACCC(A/G)TGCCC intron-variant
rs1000209857 -- 71,862,381(+) ATCTA(C/T)CAATT intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1000231577 -- 71,882,056(+) CCACA(A/G)AGAGA intron-variant
rs1000261055 -- 71,905,285(+) ACCCG(A/G)CTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABHD17B Gene

Variant ID Type Subtype PubMed ID
nsv831618 CNV loss 17160897
nsv1050324 CNV gain 25217958
esv2761535 CNV gain 21179565
esv2555630 CNV deletion 19546169

Variation tolerance for ABHD17B Gene

Residual Variation Intolerance Score: 33.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABHD17B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABHD17B Gene

Disorders for ABHD17B Gene

Relevant External Links for ABHD17B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ABHD17B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABHD17B Gene

Publications for ABHD17B Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 60
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for ABHD17B Gene

Sources for ABHD17B Gene

Loading form....