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Aliases for ABHD17B Gene

Aliases for ABHD17B Gene

  • Abhydrolase Domain Containing 17B 2 3
  • Family With Sequence Similarity 108, Member B1 2 3
  • FAM108B1 3 4
  • C9orf77 3 4
  • Alpha/Beta Hydrolase Domain-Containing Protein 17B 3
  • Abhydrolase Domain-Containing Protein FAM108B1 3
  • Chromosome 9 Open Reading Frame 77 2
  • EC 3.-.-.- 4
  • CGI-67 3

External Ids for ABHD17B Gene

Previous HGNC Symbols for ABHD17B Gene

  • C9orf77
  • FAM108B1

Previous GeneCards Identifiers for ABHD17B Gene

  • GC09M074478

Summaries for ABHD17B Gene

GeneCards Summary for ABHD17B Gene

ABHD17B (Abhydrolase Domain Containing 17B) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is ABHD17A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD17B Gene

Genomics for ABHD17B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ABHD17B Gene

Start:
71,862,452 bp from pter
End:
71,911,233 bp from pter
Size:
48,782 bases
Orientation:
Minus strand

Genomic View for ABHD17B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABHD17B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD17B Gene

No data available for Regulatory Elements for ABHD17B Gene

Proteins for ABHD17B Gene

  • Protein details for ABHD17B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VST6-AB17B_HUMAN
    Recommended name:
    Alpha/beta hydrolase domain-containing protein 17B
    Protein Accession:
    Q5VST6
    Secondary Accessions:
    • A8KAJ5
    • Q5VST7
    • Q86YB6
    • Q8IY03
    • Q9Y377

    Protein attributes for ABHD17B Gene

    Size:
    288 amino acids
    Molecular mass:
    32215 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABHD17B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABHD17B Gene

Proteomics data for ABHD17B Gene at MOPED

Post-translational modifications for ABHD17B Gene

  • Ubiquitination at Lys25, Lys63, Lys136, and Lys278
  • Modification sites at PhosphoSitePlus

Other Protein References for ABHD17B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ABHD17B Gene

Domains for ABHD17B Gene

Gene Families for ABHD17B Gene

HGNC:
  • ABHD :Abhydrolase domain containing

Protein Domains for ABHD17B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5VST6

UniProtKB/Swiss-Prot:

AB17B_HUMAN :
  • Q5VST6
Family:
  • Belongs to the AB hydrolase superfamily. ABHD17 family.
genes like me logo Genes that share domains with ABHD17B: view

No data available for Suggested Antigen Peptide Sequences for ABHD17B Gene

Function for ABHD17B Gene

Enzyme Numbers (IUBMB) for ABHD17B Gene

Gene Ontology (GO) - Molecular Function for ABHD17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008236 serine-type peptidase activity --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ABHD17B: view

Phenotypes for ABHD17B Gene

GenomeRNAi human phenotypes for ABHD17B:
genes like me logo Genes that share phenotypes with ABHD17B: view

Animal Model Products

CRISPR Products

miRNA for ABHD17B Gene

miRTarBase miRNAs that target ABHD17B

No data available for Molecular function , Animal Models , Transcription Factor Targeting and HOMER Transcription for ABHD17B Gene

Localization for ABHD17B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABHD17B Gene

Secreted.

Gene Ontology (GO) - Cellular Components for ABHD17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ABHD17B: view

No data available for Subcellular locations from COMPARTMENTS for ABHD17B Gene

Pathways for ABHD17B Gene

SuperPathways for ABHD17B Gene

No Data Available

Interacting Proteins for ABHD17B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000366240%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000366240 for ABHD17B Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for ABHD17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with ABHD17B: view

No data available for Pathways by source for ABHD17B Gene

Transcripts for ABHD17B Gene

Unigene Clusters for ABHD17B Gene

Abhydrolase domain containing 17B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABHD17B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ABHD17B
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD17B Gene

No ASD Table

Relevant External Links for ABHD17B Gene

GeneLoc Exon Structure for
ABHD17B
ECgene alternative splicing isoforms for
ABHD17B

Expression for ABHD17B Gene

mRNA expression in normal human tissues for ABHD17B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABHD17B Gene

SOURCE GeneReport for Unigene cluster for ABHD17B Gene Hs.380389

genes like me logo Genes that share expressions with ABHD17B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ABHD17B Gene

Orthologs for ABHD17B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABHD17B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABHD17B 36
  • 100 (a)
OneToOne
FAM108B1 35
  • 99.65 (n)
  • 99.65 (a)
cow
(Bos Taurus)
Mammalia FAM108B1 35
  • 95.14 (n)
  • 100 (a)
FAM108B1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABHD17B 36
  • 99 (a)
OneToOne
FAM108B1 35
  • 95.6 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Abhd17b 35
  • 90.97 (n)
  • 99.65 (a)
Abhd17b 36
  • 99 (a)
OneToOne
Fam108b 16
oppossum
(Monodelphis domestica)
Mammalia ABHD17B 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABHD17B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abhd17b 35
  • 91.78 (n)
  • 99.65 (a)
chicken
(Gallus gallus)
Aves ABHD17B 35
  • 87.15 (n)
  • 98.61 (a)
ABHD17B 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABHD17B 36
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.30366 35
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd17b 35
  • 81.25 (n)
  • 97.22 (a)
Str.7572 35
zebrafish
(Danio rerio)
Actinopterygii abhd17b 36
  • 92 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG33096 36
  • 69 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F01D5.7 36
  • 32 (a)
ManyToMany
Y71G12A.4 36
  • 18 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 19 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G13610 35
  • 55.29 (n)
  • 48.81 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.103 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8399 36
  • 70 (a)
OneToMany
Species with no ortholog for ABHD17B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABHD17B Gene

ENSEMBL:
Gene Tree for ABHD17B (if available)
TreeFam:
Gene Tree for ABHD17B (if available)

Paralogs for ABHD17B Gene

Paralogs for ABHD17B Gene

Selected SIMAP similar genes for ABHD17B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ABHD17B: view

Variants for ABHD17B Gene

Sequence variations from dbSNP and Humsavar for ABHD17B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs942393 -- 71,883,380(+) CAGAG(C/T)TTATG intron-variant
rs1183193 -- 71,882,988(+) aaaat(A/G)caaaa intron-variant
rs1404190 -- 71,876,463(-) AACTA(A/C)CAAGT intron-variant
rs1404196 -- 71,887,687(+) CAAAC(A/G)GTTCC intron-variant
rs1524383 -- 71,889,123(+) CAGCC(C/T)GGCCA intron-variant

Relevant External Links for ABHD17B Gene

HapMap Linkage Disequilibrium report
ABHD17B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ABHD17B Gene

Disorders for ABHD17B Gene

No disorders were found for ABHD17B Gene.

No data available for UniProtKB/Swiss-Prot for ABHD17B Gene

Publications for ABHD17B Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for ABHD17B Gene

Sources for ABHD17B Gene

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