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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ABHD16B Gene

protein-coding   GIFtS: 38
GCID: GC20P062493

Abhydrolase Domain Containing 16B

(Previous name: chromosome 20 open reading frame 135)
(Previous symbol: C20orf135)
  Search for ABHD16B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Abhydrolase Domain Containing 16B1 2
C20orf1351 2 3
Chromosome 20 Open Reading Frame 1351
Abhydrolase Domain-Containing Protein 16B2
dJ591C20.12
EC 3.-.-.-3

External Ids:    HGNC: 161281   Entrez Gene: 1407012   Ensembl: ENSG000001832607   UniProtKB: Q9H3Z73   

Export aliases for ABHD16B gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ABHD16B Gene: 
ABHD16B (abhydrolase domain containing 16B) is a protein-coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is ABHD16A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011333.6  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ABHD16B
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ABHD16B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABHD16B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

ABHD16B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABHD16B gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P062493:  view genomic region     (about GC identifiers)

Start:
62,492,566 bp from pter      End:
62,494,341 bp from pter
Size:
1,776 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ABHGB_HUMAN, Q9H3Z7 (See protein sequence)
Recommended Name: Abhydrolase domain-containing protein 16B  
Size: 469 amino acids; 52555 Da

Explore the universe of human proteins at neXtProt for ABHD16B: NX_Q9H3Z7

Explore proteomics data for ABHD16B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H3Z7

  • ABHD16B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ABHD16B Protein Expression
    REFSEQ proteins: NP_542189.1  
    ENSEMBL proteins: 
     ENSP00000358932  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ABHD: Abhydrolase domain containing

    1 InterPro protein domain:
     IPR026604 ABHD16

    Graphical View of Domain Structure for InterPro Entry Q9H3Z7

    ProtoNet protein and cluster: Q9H3Z7

    UniProtKB/Swiss-Prot: ABHGB_HUMAN, Q9H3Z7
    Similarity: Belongs to the AB hydrolase superfamily. ABHD16 family


    ABHD16B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Enzyme Number (IUBMB): EC 3.-.-.-1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016787hydrolase activity IEA--
         
    ABHD16B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ABHD16B:
     Decreased Hepatitis C virus re 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ABHD16B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ABHD16B (ABHGB)

    Search CenterWatch for drugs/clinical trials and news about ABHD16B / ABHGB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ABHD16B gene: 
    NM_080622.3  

    Unigene Cluster for ABHD16B:

    Abhydrolase domain containing 16B
    Hs.266774  [show with all ESTs]
    Unigene Representative Sequence: NM_080622
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369916(uc002ygx.1)
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    Additional mRNA sequence: BC031949.1 

    2 DOTS entries:

    DT.432452  DT.100750192 

    23 AceView cDNA sequences:

    CA397385 BC011481 BX283520 BC031949 CA433742 CD369075 CA416299 BI195400 
    BU194038 BC035147 AW772131 AA664327 NM_080622 CB853120 BI195097 BF344602 
    BM700775 AA779058 BI553439 BF330286 BF971540 BE242675 BF971499 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ABHD16B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGGTGGGC
    ABHD16B Expression
    About this image


    See ABHD16B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ABHD16B

    SOURCE GeneReport for Unigene cluster: Hs.266774
        SABiosciences Custom PCR Arrays for ABHD16B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABHD16B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ABHD16B gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Abhd16b1 , 5 abhydrolase domain containing 16B1, 5 78.56(n)1
    85.47(a)1
      2 (103.63 cM)5
    2418501  NM_183181.21  NP_899004.11 
     1814932065 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG13096
    --
    30(a)
    1 → many
    3L(4259430-4261643)
    worm
    (Caenorhabditis elegans)
    Secernentea F37A4.16
    Uncharacterized protein F37A4.1
    27(a)
    1 → many
    III(6723387-6725711)


    ENSEMBL Gene Tree for ABHD16B (if available)
    TreeFam Gene Tree for ABHD16B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ABHD16B gene
    ABHD16A2  
    1 SIMAP similar gene for ABHD16B using alignment to 1 protein entry:     ABHGB_HUMAN:
    ABHD16A

    ABHD16B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/100 SNPs in ABHD16B are shown (see all 100)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1398770081,2
    --62490627(+) ACTTCA/GGCTCT 1 -- us2k10--------
    rs1156002231,2
    C,F--62490749(+) GGAAAG/CGAATC 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1890573861,2
    --62490750(+) GAAAGA/GAATCA 1 -- us2k10--------
    rs1438857241,2
    --62490801(+) CACCAA/GGCTCC 1 -- us2k10--------
    rs1816874391,2
    --62490810(+) CCTTTC/TCCCAC 1 -- us2k10--------
    rs736247631,2
    C--62490875(+) CCTTGC/TCCATC 1 -- us2k10--------
    rs1863838371,2
    --62490987(+) GGACCC/GTGAGA 1 -- us2k10--------
    rs60625521,2
    C,A--62491203(+) GCCAAA/GGCGGG 1 -- us2k10--------
    rs731517061,2
    C,F--62491229(+) CAGGAG/CTTAGA 1 -- us2k17Minor allele frequency- C:0.08WA NA CSA EA 366
    rs1920108071,2
    --62491417(+) TGGGCA/GACAAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ABHD16B (62492566 - 62494341 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for ABHD16B (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509784CNV Insertion20534489
    nsv913250CNV Loss21882294
    dgv4644n71CNV Loss21882294
    nsv913190CNV Loss21882294
    nsv913267CNV Loss21882294
    dgv4648n71CNV Loss21882294
    nsv828804CNV Loss20364138
    nsv913268CNV Loss21882294
    nsv913269CNV Loss21882294
    nsv469773CNV Gain16826518

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ABHD16B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ABHD16B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S....Malek J. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    4. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 140701 HGNC: 16128 AceView: C20orf135 Ensembl:ENSG00000183260 euGenes: HUgn140701
    ECgene: ABHD16B H-InvDB: ABHD16B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ABHD16B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ABHD16B gene:
    Search GeneIP for patents involving ABHD16B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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