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Aliases for ABHD16A Gene

Aliases for ABHD16A Gene

  • Abhydrolase Domain Containing 16A 2 3 5
  • Alpha/Beta Hydrolase Domain-Containing Protein 16A 3 4
  • Abhydrolase Domain-Containing Protein 16A 3 4
  • HLA-B Associated Transcript 5 2 3
  • Protein G5 3 4
  • BAT5 3 4
  • NG26 3 4
  • HLA-B-Associated Transcript 5 4
  • EC 3.-.-.- 4
  • D6S82E 3
  • PP199 3
  • G5 4

External Ids for ABHD16A Gene

Previous HGNC Symbols for ABHD16A Gene

  • BAT5

Previous GeneCards Identifiers for ABHD16A Gene

  • GC06M031440
  • GC06M031657
  • GC06M031661
  • GC06M031665
  • GC06M031696
  • GC06M031704

Summaries for ABHD16A Gene

Entrez Gene Summary for ABHD16A Gene

  • A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is thought to be involved in some aspects of immunity. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

GeneCards Summary for ABHD16A Gene

ABHD16A (Abhydrolase Domain Containing 16A) is a Protein Coding gene. Diseases associated with ABHD16A include Coronary Artery Aneurysm. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is ABHD16B.

Gene Wiki entry for ABHD16A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD16A Gene

Genomics for ABHD16A Gene

Regulatory Elements for ABHD16A Gene

Enhancers for ABHD16A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ABHD16A on UCSC Golden Path with GeneCards custom track

Promoters for ABHD16A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ABHD16A on UCSC Golden Path with GeneCards custom track

Genomic Location for ABHD16A Gene

Chromosome:
6
Start:
31,686,949 bp from pter
End:
31,703,444 bp from pter
Size:
16,496 bases
Orientation:
Minus strand

Genomic View for ABHD16A Gene

Genes around ABHD16A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABHD16A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABHD16A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for ABHD16A Gene

  • Protein details for ABHD16A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95870-ABHGA_HUMAN
    Recommended name:
    Protein ABHD16A
    Protein Accession:
    O95870
    Secondary Accessions:
    • A2BEY3
    • B7Z4R6
    • Q5SRR1
    • Q5SRR2
    • Q8WYH0
    • Q9NW33

    Protein attributes for ABHD16A Gene

    Size:
    558 amino acids
    Molecular mass:
    63243 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI17808.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI18401.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAM26084.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAM45793.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ABHD16A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABHD16A Gene

Proteomics data for ABHD16A Gene at MOPED

Post-translational modifications for ABHD16A Gene

  • Ubiquitination at Lys 452
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ABHD16A Gene

Domains & Families for ABHD16A Gene

Gene Families for ABHD16A Gene

Protein Domains for ABHD16A Gene

Graphical View of Domain Structure for InterPro Entry

O95870

UniProtKB/Swiss-Prot:

ABHGA_HUMAN :
  • Belongs to the AB hydrolase superfamily. ABHD16 family.
Family:
  • Belongs to the AB hydrolase superfamily. ABHD16 family.
genes like me logo Genes that share domains with ABHD16A: view

Function for ABHD16A Gene

Enzyme Numbers (IUBMB) for ABHD16A Gene

Gene Ontology (GO) - Molecular Function for ABHD16A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14667819
genes like me logo Genes that share ontologies with ABHD16A: view
genes like me logo Genes that share phenotypes with ABHD16A: view

Animal Model Products

CRISPR Products

miRNA for ABHD16A Gene

miRTarBase miRNAs that target ABHD16A

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABHD16A Gene

Localization for ABHD16A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABHD16A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABHD16A Gene COMPARTMENTS Subcellular localization image for ABHD16A gene
Compartment Confidence
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for ABHD16A Gene

Pathways & Interactions for ABHD16A Gene

SuperPathways for ABHD16A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ABHD16A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ABHD16A Gene

Drugs & Compounds for ABHD16A Gene

No Compound Related Data Available

Transcripts for ABHD16A Gene

Unigene Clusters for ABHD16A Gene

Abhydrolase domain containing 16A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD16A Gene

No ASD Table

Relevant External Links for ABHD16A Gene

GeneLoc Exon Structure for
ABHD16A
ECgene alternative splicing isoforms for
ABHD16A

Expression for ABHD16A Gene

mRNA expression in normal human tissues for ABHD16A Gene

Protein differential expression in normal tissues from HIPED for ABHD16A Gene

This gene is overexpressed in Nasal epithelium (23.7) and Peripheral blood mononuclear cells (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ABHD16A Gene



SOURCE GeneReport for Unigene cluster for ABHD16A Gene Hs.388188

genes like me logo Genes that share expression patterns with ABHD16A: view

Protein tissue co-expression partners for ABHD16A Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ABHD16A Gene

Orthologs for ABHD16A Gene

This gene was present in the common ancestor of animals.

Orthologs for ABHD16A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ABHD16A 35
  • 93.85 (n)
  • 96.95 (a)
ABHD16A 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABHD16A 35
  • 93.13 (n)
  • 96.06 (a)
ABHD16A 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abhd16a 35
  • 90.62 (n)
  • 96.06 (a)
Abhd16a 16
Abhd16a 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ABHD16A 35
  • 99.64 (n)
  • 99.82 (a)
ABHD16A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abhd16a 35
  • 90.8 (n)
  • 95.34 (a)
oppossum
(Monodelphis domestica)
Mammalia ABHD16A 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABHD16A 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABHD16A 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd16a 35
  • 68.61 (n)
  • 72.91 (a)
Str.10410 35
African clawed frog
(Xenopus laevis)
Amphibia bat5-prov 35
zebrafish
(Danio rerio)
Actinopterygii abhd16a 35
  • 68.09 (n)
  • 68.53 (a)
wufb55e01 35
abhd16a 36
  • 65 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005364 35
  • 52.74 (n)
  • 46.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1309 35
  • 52.93 (n)
  • 45.96 (a)
CG1309 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F37A4.1 35
  • 47.76 (n)
  • 37.89 (a)
F37A4.1 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
ManyToMany
CSA.9728 36
  • 40 (a)
ManyToMany
Species with no ortholog for ABHD16A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABHD16A Gene

ENSEMBL:
Gene Tree for ABHD16A (if available)
TreeFam:
Gene Tree for ABHD16A (if available)

Paralogs for ABHD16A Gene

Paralogs for ABHD16A Gene

(1) SIMAP similar genes for ABHD16A Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ABHD16A: view

Variants for ABHD16A Gene

Sequence variations from dbSNP and Humsavar for ABHD16A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1266072 -- 31,699,425(-) ctttt(C/T)ttttt intron-variant
rs1266073 -- 31,699,251(-) ttttt(G/T)tattt intron-variant
rs1266074 -- 31,698,774(-) gcagg(A/G)ctggg intron-variant
rs10573 -- 31,687,661(+) AAGTC(A/G)GGCCC nc-transcript-variant, reference, synonymous-codon
rs11552114 -- 31,693,071(-) GCAGA(C/T)ACCCT nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ABHD16A Gene

Variant ID Type Subtype PubMed ID
nsv830627 CNV Loss 17160897
nsv884418 CNV Gain 21882294

Variation tolerance for ABHD16A Gene

Residual Variation Intolerance Score: 47.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.87; 59.00% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ABHD16A Gene

Disorders for ABHD16A Gene

MalaCards: The human disease database

(1) MalaCards diseases for ABHD16A Gene - From: GeneCards

Disorder Aliases PubMed IDs
coronary artery aneurysm
  • coronary aneurysm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ABHD16A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABHD16A
genes like me logo Genes that share disorders with ABHD16A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ABHD16A Gene

Publications for ABHD16A Gene

  1. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B. (PMID: 2813433) Spies T. … Strominger J.L. (Proc. Natl. Acad. Sci. U.S.A. 1989) 2 3
  3. A new cluster of genes within the human major histocompatibility complex. (PMID: 2911734) Spies T. … Strominger J.L. (Science 1989) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for ABHD16A Gene

Sources for ABHD16A Gene

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