ABHD15 Gene
protein-coding GIFtS: 38
GCID: GC17M027887
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|
abhydrolase domain containing 15
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Aliases
for ABHD15 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Abhydrolase Domain Containing 151 2 | | Abhydrolase Domain-Containing Protein 152 | | EC 3.1.1.-3 |
Export aliases for ABHD15 gene to outside databasesPrevious GC identifers: GC17M024912 GC17M024097 |
Summaries
for ABHD15 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ABHD15 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010799.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ABHD15 gene promoter:
Nkx6-1 p53 NRSF form 1 MRF-2 NRSF form 2 Roaz c-Ets-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ABHD15
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABHD15 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11.2ABHD15 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M027887: view genomic region
(about GC identifiers)
Start:
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27,887,565 bp from pter |
End:
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27,894,155 bp from pter |
Size:
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6,591 bases |
Orientation:
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minus strand |
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Proteins
for ABHD15 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ABH15_HUMAN, Q6UXT9 (See
protein sequence)Recommended Name: Abhydrolase domain-containing protein 15 precursor Size: 468 amino acids; 51771 Da
Subcellular location: Secreted (Potential)
Secondary accessions: Q96EC5Explore the universe of human proteins at neXtProt for ABHD15: NX_Q6UXT9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6UXT9
ABHD15 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_937790.2
ENSEMBL proteins: ENSP00000302657
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
ABHD15 for ontologies About GeneDecksing
ABHD15 Antibody Products:
Assay Products for ABHD15: |
Protein
Domains /
Families
for ABHD15 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ABHD15 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6UXT9ProtoNet protein and cluster: Q6UXT9 UniProtKB/Swiss-Prot: ABH15_HUMAN, Q6UXT9Similarity: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family |
Function
for ABHD15 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Number (IUBMB): EC 3.1.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD15 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD15
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ABHD15 (NM_198147) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ABHD15 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABHD15 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABHD15 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004091 | carboxylesterase activity |
IEA | -- |
ABHD15 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ABHD15:
|
Pathways & Interactions
for ABHD15 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ABHD15
|
Drugs & Compounds
for ABHD15 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ABHD15
Search CenterWatch for drugs/clinical trials and news about ABHD15 / ABH15
|
Transcripts
for ABHD15 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ABHD15 gene: NM_198147.2 Unigene Cluster for ABHD15: Abhydrolase domain containing 15 Hs.106510 [show with all ESTs]Unigene Representative Sequence: BC0124761 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000307201(uc002hed.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD15 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD15
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ABHD15 (NM_198147) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ABHD15 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABHD15 |
Additional cDNA sequence: AK055889.1 AK056717.1 AY358212.1 BC012476.1 3 DOTS entries: DT.212275 DT.91638615 DT.95337389 24/62 AceView cDNA sequences (see all 62): AA826277 BM677379 BG742782 CA432737 BX110575 BM722910 AA378656 CK824710 AI805481 AY358212 NM_198147 BG391086 AA744368 BE646444 AI141814 AA279336 BM759899 AK055889 CA427433 BG248211 BE878279 AA827793 AI524112 BE873232
GeneLoc Exon Structure
|
Expression
for ABHD15 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ABHD15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTGCTAAG
About this image
See ABHD15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ABHD15
SOURCE GeneReport for Unigene cluster: Hs.106510
SABiosciences Custom PCR Arrays for ABHD15
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABHD15
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ABHD15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABHD15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABHD15 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABHD15 |
Orthologs
for ABHD15 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for ABHD15 gene from 3/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.80452 |
Xenopus laevis transcribed sequence with weak similarity more |
68.59(n) |
|
48012196 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5606441 |
abhydrolase domain-containing protein 15-like |
58.54(n)
55.03(a) |
|
560644 XM_684039.5 XP_689131.3 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
yheT6 |
predicted hydrolase |
20(a) |
possible ortholog |
Chromosome(3481224-3482246) |
ENSEMBL Gene Tree for ABHD15 (if available)
TreeFam Gene Tree for ABHD15 (if available) |
Paralogs
for ABHD15 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ABHD15 gene
- ABHD12 ABHD32 ABHD22
ABHD15 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for ABHD15
PGOHUM00000232776 PGOHUM00000233299
|
Genomic Variants
for ABHD15 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ABHD15 (27887565 - 27894155 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ABHD15
1 CNV: 72855 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABHD15 |
|
Disorders
/ Diseases
for ABHD15 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ABHD15 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ABHD15 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ABHD15) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for ABHD15 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ABHD15 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ABHD15 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ABHD15 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ABHD15 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ABHD15 gene:
Search GeneIP for patents involving ABHD15
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ABHD15 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ABHD15 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABHD15 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABHD15 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ABHD15 | | OriGene 3'-UTR Clone for ABHD15 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD15 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD15 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ABHD15 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABHD15 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABHD15 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABHD15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABHD15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABHD15 |
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 | | | ABHD15 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABHD15 |
|  |  |  | | | | Search ThermoFisher Antibodies for ABHD15 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABHD15 |
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