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ABHD15 Gene

protein-coding   GIFtS: 42
GCID: GC17M027887

Abhydrolase Domain Containing 15

  Search for ABHD15
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Abhydrolase Domain Containing 151 2
Abhydrolase Domain-Containing Protein 152
EC 3.1.1.-3

External Ids:    HGNC: 269711   Entrez Gene: 1162362   Ensembl: ENSG000001687927   UniProtKB: Q6UXT93   

Export aliases for ABHD15 gene to outside databases

Previous GC identifers: GC17M024912 GC17M024097


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ABHD15 Gene:
ABHD15 (abhydrolase domain containing 15) is a protein-coding gene. GO annotations related to this gene include . An important paralog of this gene is ABHD1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ABHD15 gene promoter:
         Nkx6-1   p53   NRSF form 1   MRF-2   NRSF form 2   Roaz   c-Ets-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ABHD15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ABHD15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

ABHD15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABHD15 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M027887:  view genomic region     (about GC identifiers)

Start:
27,887,565 bp from pter      End:
27,894,155 bp from pter
Size:
6,591 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ABH15_HUMAN, Q6UXT9 (See protein sequence)
Recommended Name: Abhydrolase domain-containing protein 15 precursor  
Size: 468 amino acids; 51771 Da
Secondary accessions: Q96EC5

Explore the universe of human proteins at neXtProt for ABHD15: NX_Q6UXT9

Explore proteomics data for ABHD15 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ABHD15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_937790.2  
    ENSEMBL proteins: 
     ENSP00000302657  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ABHD: Abhydrolase domain containing

    1 InterPro protein domain:
     IPR012020 AB-Hydro_YheT

    Graphical View of Domain Structure for InterPro Entry Q6UXT9

    ProtoNet protein and cluster: Q6UXT9

    UniProtKB/Swiss-Prot: ABH15_HUMAN, Q6UXT9
    Similarity: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family


    Find genes that share domains with ABHD15           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Enzyme Number (IUBMB): EC 3.1.1.-1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016787hydrolase activity IEA--
         
    Find genes that share ontologies with ABHD15           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ABHD15:
     Decreased Wnt reporter activit 

    Animal Models:
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    hsa-miR-140-3p hsa-miR-3140-3p hsa-miR-450b-3p hsa-miR-548aa hsa-miR-766 hsa-miR-3126-5p hsa-miR-4267 hsa-miR-629*
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ABH15_HUMAN, Q6UXT9: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    cytosol1
    golgi apparatus1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with ABHD15           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ABHD15
    Interactions:

        Search GeneGlobe Interaction Network for ABHD15

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ABHD15 (ENSP000003026574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YIPF1ENSP000000726444STRING: ENSP00000072644
    YIPF2ENSP000002530314STRING: ENSP00000253031
    --ENSP000002597374STRING: ENSP00000259737
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ABHD15 (ABH15)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ABHD15 gene: 
    NM_198147.2  

    Unigene Cluster for ABHD15:

    Abhydrolase domain containing 15
    Hs.106510  [show with all ESTs]
    Unigene Representative Sequence: BC012476
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000307201(uc002hed.2)
    miRNA
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    hsa-miR-140-3p hsa-miR-3140-3p hsa-miR-450b-3p hsa-miR-548aa hsa-miR-766 hsa-miR-3126-5p hsa-miR-4267 hsa-miR-629*
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    Additional mRNA sequence: 

    AK055889.1 AK056717.1 AY358212.1 BC012476.1 

    3 DOTS entries:

    DT.212275  DT.91638615  DT.95337389 

    Selected AceView cDNA sequences (see all 62):

    BM759899 BG391086 BX110575 AA378656 NM_198147 AA279336 BG742782 BE646444 
    CA427433 AI805481 AY358212 AA744368 BM677379 AI141814 AK055889 CK824710 
    AA826277 CA432737 BM722910 AA827793 BI089267 AW612790 BE878279 AI524112 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ABHD15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTGCTAAG
    ABHD15 Expression
    About this image

    ABHD15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ABHD15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.106510
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABHD15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ABHD15 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Abhd151 , 5 abhydrolase domain containing 151, 5 85.01(n)1
    88.58(a)1
      11 (46.63 cM)5
    674771  NM_026185.41  NP_080461.31 
     775151215 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.80452 Xenopus laevis transcribed sequence with weak similarity more 68.59(n)    48012196 
    zebrafish
    (Danio rerio)
    Actinopterygii ABHD156
    abhydrolase domain containing 15
    46(a)
    1 ↔ 1
    11(6492761-6495395) ENSDARG00000079748
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes EHT16
    EEB16
    (see all 3)
    Acyl-coenzymeA:ethanol O-acyltransferase that play...
    Acyl-coenzymeA:ethanol O-acyltransferase responsib...
    (see all 3)
    16(a)
    14(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    II(584807-586162) YBR177C
    XVI(368071-369441) YPL095C


    ENSEMBL Gene Tree for ABHD15 (if available)
    TreeFam Gene Tree for ABHD15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ABHD15 gene
    ABHD12  ABHD32  ABHD22  

    Find genes that share paralogs with ABHD15           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ABHD15
    PGOHUM00000232776 PGOHUM00000233299


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ABHD15 (see all 162)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1890661071,2
    --27887356(+) TTTCAC/TCCTTA 1 -- ds50010--------
    rs761693461,2
    C--27887483(+) AGCTGG/TTGGTA 1 -- ds50010--------
    rs115531251,2
    C--27887528(-) GTGTAA/GGCCTT 1 -- ds50012Minor allele frequency- G:0.00NA 4
    rs1921219561,2
    --27887550(+) TTCACC/TGGCAG 1 -- ds50010--------
    rs1405931401,2
    --27888497(+) GGATGA/GCCTTT 1 -- ut310--------
    rs1833318531,2
    --27888519(+) GCAGAC/TGAAGC 1 -- ut310--------
    rs1155655551,2
    C,F--27888654(+) AAAGGG/TAGCAA 1 -- ut311Minor allele frequency- T:0.02WA 118
    rs744841331,2
    C--27888737(+) AAACAA/GTTCTG 1 -- ut310--------
    rs758330251,2
    C--27888761(+) GGAGTA/GATCCC 1 -- ut310--------
    rs1168326361,2
    F--27888773(+) TGAAAT/CGGTGC 1 -- ut311Minor allele frequency- C:0.01WA 118

    HapMap Linkage Disequilibrium report for ABHD15 (27887565 - 27894155 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ABHD15:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv521557CNV Loss19592680
    esv22811CNV Loss19812545
    nsv908033CNV Loss21882294
    dgv3135n71CNV Loss21882294
    nsv833409CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ABHD15 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ABHD15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 116236 HGNC: 26971 AceView: LOC116236 Ensembl:ENSG00000168792 euGenes: HUgn116236
    ECgene: ABHD15 H-InvDB: ABHD15

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ABHD15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ABHD15 gene:
    Search GeneIP for patents involving ABHD15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Block miRNA regulation of human, mouse, rat ABHD15 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ABHD15
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ABHD15 Predesigned siRNA for gene silencing in human, mouse, rat ABHD15
     QuantiFast Probe-based Assays in human, mouse, rat ABHD15 QuantiTect SYBR Green Assays in human, mouse, rat ABHD15
     Custom PCR Arrays for ABHD15 Search Chromatin IP Primers for ABHD15
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     Search Tocris compounds for ABHD15 (ABH15)
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ABHD15
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ABHD15
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     Search Addgene for plasmids for ABHD15
      Search eBioscience for proteins for ABHD15
      Search eBioscience for elisas for ABHD15
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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