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Aliases for ABHD15 Gene

Aliases for ABHD15 Gene

  • Abhydrolase Domain Containing 15 2 3 5
  • Alpha/Beta Hydrolase Domain-Containing Protein 15 4
  • Abhydrolase Domain-Containing Protein 15 4
  • EC 3.1.1.- 4

External Ids for ABHD15 Gene

Previous GeneCards Identifiers for ABHD15 Gene

  • GC17M024912
  • GC17M027887
  • GC17M024097

Summaries for ABHD15 Gene

GeneCards Summary for ABHD15 Gene

ABHD15 (Abhydrolase Domain Containing 15) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is ABHD3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD15 Gene

Genomics for ABHD15 Gene

Regulatory Elements for ABHD15 Gene

Enhancers for ABHD15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ABHD15 on UCSC Golden Path with GeneCards custom track

Genomic Location for ABHD15 Gene

29,560,547 bp from pter
29,567,137 bp from pter
6,591 bases
Minus strand

Genomic View for ABHD15 Gene

Genes around ABHD15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABHD15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABHD15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD15 Gene

Proteins for ABHD15 Gene

  • Protein details for ABHD15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein ABHD15
    Protein Accession:
    Secondary Accessions:
    • Q96EC5

    Protein attributes for ABHD15 Gene

    468 amino acids
    Molecular mass:
    51771 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ABHD15 Gene

Post-translational modifications for ABHD15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ABHD15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ABHD15 Gene

Domains & Families for ABHD15 Gene

Gene Families for ABHD15 Gene

Protein Domains for ABHD15 Gene


Suggested Antigen Peptide Sequences for ABHD15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.
  • Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.
genes like me logo Genes that share domains with ABHD15: view

Function for ABHD15 Gene

Enzyme Numbers (IUBMB) for ABHD15 Gene

Gene Ontology (GO) - Molecular Function for ABHD15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ABHD15: view
genes like me logo Genes that share phenotypes with ABHD15: view

Animal Model Products

CRISPR Products

miRNA for ABHD15 Gene

miRTarBase miRNAs that target ABHD15

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABHD15 Gene

Localization for ABHD15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABHD15 Gene


Subcellular locations from

Jensen Localization Image for ABHD15 Gene COMPARTMENTS Subcellular localization image for ABHD15 gene
Compartment Confidence
extracellular 3
cytosol 2
nucleus 2
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ABHD15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ABHD15: view

Pathways & Interactions for ABHD15 Gene

SuperPathways for ABHD15 Gene

No Data Available

Interacting Proteins for ABHD15 Gene

Gene Ontology (GO) - Biological Process for ABHD15 Gene


No data available for Pathways by source and SIGNOR curated interactions for ABHD15 Gene

Drugs & Compounds for ABHD15 Gene

No Compound Related Data Available

Transcripts for ABHD15 Gene

mRNA/cDNA for ABHD15 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(62) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ABHD15 Gene

Abhydrolase domain containing 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD15 Gene

No ASD Table

Relevant External Links for ABHD15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ABHD15 Gene

mRNA expression in normal human tissues for ABHD15 Gene

Protein differential expression in normal tissues from HIPED for ABHD15 Gene

This gene is overexpressed in Kidney (23.4), Spleen (23.3), and Heart (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABHD15 Gene

NURSA nuclear receptor signaling pathways regulating expression of ABHD15 Gene:


SOURCE GeneReport for Unigene cluster for ABHD15 Gene:

genes like me logo Genes that share expression patterns with ABHD15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ABHD15 Gene

Orthologs for ABHD15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ABHD15 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ABHD15 34
  • 88.68 (n)
  • 89.74 (a)
ABHD15 35
  • 90 (a)
(Canis familiaris)
Mammalia ABHD15 34
  • 88.2 (n)
  • 90.64 (a)
ABHD15 35
  • 89 (a)
(Mus musculus)
Mammalia Abhd15 34
  • 85.01 (n)
  • 88.58 (a)
Abhd15 16
Abhd15 35
  • 88 (a)
(Pan troglodytes)
Mammalia ABHD15 34
  • 99 (n)
  • 99.15 (a)
ABHD15 35
  • 99 (a)
(Rattus norvegicus)
Mammalia Abhd15 34
  • 84.09 (n)
  • 87.21 (a)
(Monodelphis domestica)
Mammalia ABHD15 35
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd15 34
  • 57.96 (n)
  • 57.72 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8045 34
(Danio rerio)
Actinopterygii ABHD15 35
  • 46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 14 (a)
EEB1 35
  • 14 (a)
EHT1 35
  • 16 (a)
Species where no ortholog for ABHD15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABHD15 Gene

Gene Tree for ABHD15 (if available)
Gene Tree for ABHD15 (if available)

Paralogs for ABHD15 Gene

Paralogs for ABHD15 Gene Pseudogenes for ABHD15 Gene

genes like me logo Genes that share paralogs with ABHD15: view

Variants for ABHD15 Gene

Sequence variations from dbSNP and Humsavar for ABHD15 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs542939 - 29,562,968(+) GTAGG(C/T)ATCCC reference, missense
rs539307 -- 29,562,560(+) GGTCT(C/G/T)TCACC utr-variant-3-prime
rs636000 -- 29,564,846(+) CTAAG(A/G)AAGCC intron-variant
rs721478 -- 29,562,785(+) GCGCA(A/G)GAAGC reference, synonymous-codon
rs721479 -- 29,562,945(+) CGGAG(A/C/G)GGGTC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ABHD15 Gene

Variant ID Type Subtype PubMed ID
esv22811 CNV loss 19812545
nsv521557 CNV loss 19592680
nsv833409 CNV gain 17160897

Variation tolerance for ABHD15 Gene

Residual Variation Intolerance Score: 75.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.45; 54.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABHD15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABHD15 Gene

Disorders for ABHD15 Gene

Relevant External Links for ABHD15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ABHD15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABHD15 Gene

Publications for ABHD15 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 65
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 65
  3. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D. … Wilkins J.A. (J Mass Spectrom 2010) 3 65
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 65

Products for ABHD15 Gene

Sources for ABHD15 Gene

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