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Aliases for ABHD14B Gene

Aliases for ABHD14B Gene

  • Abhydrolase Domain Containing 14B 2 3 5
  • Alpha/Beta Hydrolase Domain-Containing Protein 14B 3 4
  • Abhydrolase Domain-Containing Protein 14B 3 4
  • CCG1-Interacting Factor B 3 4
  • CIB 3 4
  • Cell Cycle Gene 1-Interacting Factor B 3
  • Epididymis Secretory Protein Li 299 3
  • Protein ABHD14B 3
  • EC 3.1.21.4 58
  • EC 3.1.11.6 58
  • EC 3.-.-.- 4
  • HEL-S-299 3

External Ids for ABHD14B Gene

Previous GeneCards Identifiers for ABHD14B Gene

  • GC03M051978

Summaries for ABHD14B Gene

GeneCards Summary for ABHD14B Gene

ABHD14B (Abhydrolase Domain Containing 14B) is a Protein Coding gene. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is ABHD14A.

UniProtKB/Swiss-Prot for ABHD14B Gene

  • Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription.

Additional gene information for ABHD14B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD14B Gene

Genomics for ABHD14B Gene

Regulatory Elements for ABHD14B Gene

Enhancers for ABHD14B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H052236 1.7 FANTOM5 ENCODE dbSUPER 10.4 -255.4 -255380 5 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 GLYCTK RAD54L2 PBRM1 RRP9 LOC101929054 WDR82 RFT1 MIR135A1 GLYCTK-AS1 ABHD14B
GH03H052108 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -126.1 -126079 2 CTCF RFX1 NCOR1 SCRT2 FOXJ2 REST DUSP7 ABHD14B ABHD14A PCBP4 ABHD14A-ACY1 GPR62 GLYCTK WDR82 MIR135A1 GLYCTK-AS1
GH03H052683 1.4 ENCODE dbSUPER 10.4 -702.9 -702912 5 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 PBRM1 GNL3 RFT1 RRP9 ABHD14B ITIH1 ENSG00000280904
GH03H052153 1.1 ENCODE 10.5 -171.1 -171057 2 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 SP3 DUSP7 ABHD14A-ACY1 ABHD14B PCBP4 ACY1 WDR82 GPR62 PBRM1 POC1A LINC00696
GH03H052086 1.6 FANTOM5 Ensembl ENCODE dbSUPER 4.3 -106.2 -106155 6 JUN CEBPG EBF1 ZIC2 POLR2A EGR1 EED SCRT2 FOS PRDM10 GPR62 DUSP7 PCBP4 ABHD14B PPM1M GLYCTK LINC00696 POC1A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ABHD14B on UCSC Golden Path with GeneCards custom track

Promoters for ABHD14B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000152462 109 1001 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF766 ZNF143

Genomic Location for ABHD14B Gene

Chromosome:
3
Start:
51,968,510 bp from pter
End:
51,983,409 bp from pter
Size:
14,900 bases
Orientation:
Minus strand

Genomic View for ABHD14B Gene

Genes around ABHD14B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABHD14B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABHD14B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD14B Gene

Proteins for ABHD14B Gene

  • Protein details for ABHD14B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IU4-ABHEB_HUMAN
    Recommended name:
    Protein ABHD14B
    Protein Accession:
    Q96IU4
    Secondary Accessions:
    • Q86VK8
    • Q8N8W5

    Protein attributes for ABHD14B Gene

    Size:
    210 amino acids
    Molecular mass:
    22346 Da
    Quaternary structure:
    • May interact with TAF1.
    SequenceCaution:
    • Sequence=AAH50650.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ABHD14B Gene

    Alternative splice isoforms for ABHD14B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABHD14B Gene

Selected DME Specific Peptides for ABHD14B Gene

Q96IU4:
  • GLLDFLQ
  • LHRLAQA

Post-translational modifications for ABHD14B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ABHD14B Gene

Antibody Products

  • Abcam antibodies for ABHD14B
  • Santa Cruz Biotechnology (SCBT) Antibodies for ABHD14B

Domains & Families for ABHD14B Gene

Gene Families for ABHD14B Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ABHD14B Gene

Graphical View of Domain Structure for InterPro Entry

Q96IU4

UniProtKB/Swiss-Prot:

ABHEB_HUMAN :
  • Belongs to the AB hydrolase superfamily. ABHD14 family.
Family:
  • Belongs to the AB hydrolase superfamily. ABHD14 family.
genes like me logo Genes that share domains with ABHD14B: view

Function for ABHD14B Gene

Molecular function for ABHD14B Gene

UniProtKB/Swiss-Prot Function:
Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription.

Enzyme Numbers (IUBMB) for ABHD14B Gene

Phenotypes From GWAS Catalog for ABHD14B Gene

Gene Ontology (GO) - Molecular Function for ABHD14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14672934
GO:0016787 hydrolase activity TAS --
genes like me logo Genes that share ontologies with ABHD14B: view
genes like me logo Genes that share phenotypes with ABHD14B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ABHD14B

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ABHD14B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABHD14B Gene

Localization for ABHD14B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABHD14B Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABHD14B gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ABHD14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 14672934
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ABHD14B: view

Pathways & Interactions for ABHD14B Gene

genes like me logo Genes that share pathways with ABHD14B: view

Pathways by source for ABHD14B Gene

Gene Ontology (GO) - Biological Process for ABHD14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 14672934
GO:0050427 3-phosphoadenosine 5-phosphosulfate metabolic process TAS --
genes like me logo Genes that share ontologies with ABHD14B: view

No data available for SIGNOR curated interactions for ABHD14B Gene

Drugs & Compounds for ABHD14B Gene

No Compound Related Data Available

Transcripts for ABHD14B Gene

Unigene Clusters for ABHD14B Gene

Abhydrolase domain containing 14B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ABHD14B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD14B Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: -
SP2: - -
SP3: -
SP4: - - -
SP5: -

Relevant External Links for ABHD14B Gene

GeneLoc Exon Structure for
ABHD14B
ECgene alternative splicing isoforms for
ABHD14B

Expression for ABHD14B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ABHD14B Gene

Protein differential expression in normal tissues from HIPED for ABHD14B Gene

This gene is overexpressed in Liver, secretome (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABHD14B Gene



Protein tissue co-expression partners for ABHD14B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ABHD14B Gene:

ABHD14B

SOURCE GeneReport for Unigene cluster for ABHD14B Gene:

Hs.420796

mRNA Expression by UniProt/SwissProt for ABHD14B Gene:

Q96IU4-ABHEB_HUMAN
Tissue specificity: Ubiquitous. Detected in spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocyte, heart, placenta, lung, liver, skeletal muscle, pancreas and kidney.

Evidence on tissue expression from TISSUES for ABHD14B Gene

  • Lung(4.5)
  • Liver(4.4)
  • Skin(4.4)
  • Kidney(4.3)
  • Nervous system(3.3)
  • Intestine(2.7)
  • Blood(2)
genes like me logo Genes that share expression patterns with ABHD14B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABHD14B Gene

Orthologs for ABHD14B Gene

This gene was present in the common ancestor of animals.

Orthologs for ABHD14B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABHD14B 33 34
  • 99.21 (n)
cow
(Bos Taurus)
Mammalia ABHD14B 33 34
  • 91.47 (n)
dog
(Canis familiaris)
Mammalia ABHD14B 33 34
  • 89.21 (n)
mouse
(Mus musculus)
Mammalia Abhd14b 33 16 34
  • 87.6 (n)
rat
(Rattus norvegicus)
Mammalia Abhd14b 33
  • 86.15 (n)
oppossum
(Monodelphis domestica)
Mammalia ABHD14B 34
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABHD14B 34
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABHD14B 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd14b 33
  • 62.98 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68600 33
zebrafish
(Danio rerio)
Actinopterygii abhd14b 33 34
  • 65.06 (n)
zgc64031 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9461 33
worm
(Caenorhabditis elegans)
Secernentea Y55F3AM.10 33 34
  • 46.83 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
ManyToMany
CSA.1288 34
  • 29 (a)
ManyToMany
Species where no ortholog for ABHD14B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABHD14B Gene

ENSEMBL:
Gene Tree for ABHD14B (if available)
TreeFam:
Gene Tree for ABHD14B (if available)

Paralogs for ABHD14B Gene

Paralogs for ABHD14B Gene

(1) SIMAP similar genes for ABHD14B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ABHD14B: view

Variants for ABHD14B Gene

Sequence variations from dbSNP and Humsavar for ABHD14B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000151826 -- 51,972,969(+) ACCTC(C/G)TGGGT intron-variant
rs1000379596 -- 51,974,409(+) CCAGT(A/G)TCCAG upstream-variant-2KB, utr-variant-5-prime
rs1000477725 -- 51,974,810(+) TGACC(C/T)GTCCT upstream-variant-2KB
rs1000946519 -- 51,974,665(+) TCTGA(C/T)CGTGG upstream-variant-2KB
rs1001359207 -- 51,969,037(+) GAGGT(A/G)GGGAA upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ABHD14B Gene

Variant ID Type Subtype PubMed ID
nsv1003453 CNV gain 25217958
nsv508922 CNV insertion 20534489
nsv519445 CNV gain+loss 19592680
nsv520211 CNV gain 19592680
nsv954857 CNV deletion 24416366

Variation tolerance for ABHD14B Gene

Residual Variation Intolerance Score: 76.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.59; 44.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABHD14B Gene

Human Gene Mutation Database (HGMD)
ABHD14B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABHD14B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABHD14B Gene

Disorders for ABHD14B Gene

Relevant External Links for ABHD14B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABHD14B

No disorders were found for ABHD14B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABHD14B Gene

Publications for ABHD14B Gene

  1. Purification, crystallization and preliminary X-ray crystallographic analysis of human CCG1-interacting factor B. (PMID: 11053859) Padmanabhan B … Horikoshi M (Acta crystallographica. Section D, Biological crystallography 2000) 3 4 22 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The crystal structure of CCG1/TAF(II)250-interacting factor B (CIB). (PMID: 14672934) Padmanabhan B … Horikoshi M (The Journal of biological chemistry 2004) 3 4 60
  5. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 60

Products for ABHD14B Gene

Sources for ABHD14B Gene

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