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Aliases for ABHD14B Gene

Aliases for ABHD14B Gene

  • Abhydrolase Domain Containing 14B 2 3
  • Abhydrolase Domain-Containing Protein 14B 3 4
  • CCG1-Interacting Factor B 3 4
  • CIB 3 4
  • Alpha/Beta Hydrolase Domain-Containing Protein 14B 3
  • Cell Cycle Gene 1-Interacting Factor B 3
  • Epididymis Secretory Protein Li 299 3
  • EC 63
  • EC 63
  • EC 3.-.-.- 4
  • HEL-S-299 3

External Ids for ABHD14B Gene

Previous GeneCards Identifiers for ABHD14B Gene

  • GC03M051978

Summaries for ABHD14B Gene

GeneCards Summary for ABHD14B Gene

ABHD14B (Abhydrolase Domain Containing 14B) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is ABHD14A.

UniProtKB/Swiss-Prot for ABHD14B Gene

  • Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD14B Gene

Genomics for ABHD14B Gene

Regulatory Elements for ABHD14B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ABHD14B Gene

51,968,510 bp from pter
51,983,409 bp from pter
14,900 bases
Minus strand

Genomic View for ABHD14B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABHD14B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD14B Gene

Proteins for ABHD14B Gene

  • Protein details for ABHD14B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha/beta hydrolase domain-containing protein 14B
    Protein Accession:
    Secondary Accessions:
    • Q86VK8
    • Q8N8W5

    Protein attributes for ABHD14B Gene

    210 amino acids
    Molecular mass:
    22346 Da
    Quaternary structure:
    • May interact with TAF1
    • Sequence=AAH50650.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ABHD14B Gene

    Alternative splice isoforms for ABHD14B Gene


neXtProt entry for ABHD14B Gene

Proteomics data for ABHD14B Gene at MOPED

Selected DME Specific Peptides for ABHD14B Gene

Post-translational modifications for ABHD14B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ABHD14B Gene

Antibody Products

Domains for ABHD14B Gene

Gene Families for ABHD14B Gene

  • ABHD :Abhydrolase domain containing

Protein Domains for ABHD14B Gene

Graphical View of Domain Structure for InterPro Entry



  • Q96IU4
  • Belongs to the AB hydrolase superfamily. ABHD14 family.
genes like me logo Genes that share domains with ABHD14B: view

Function for ABHD14B Gene

Molecular function for ABHD14B Gene

UniProtKB/Swiss-Prot Function:
Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription.

Enzyme Numbers (IUBMB) for ABHD14B Gene

Gene Ontology (GO) - Molecular Function for ABHD14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14672934
GO:0016787 hydrolase activity IDA 14672934
genes like me logo Genes that share ontologies with ABHD14B: view

Animal Model Products

CRISPR Products

miRNA for ABHD14B Gene

miRTarBase miRNAs that target ABHD14B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABHD14B

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ABHD14B Gene

Localization for ABHD14B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABHD14B Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.

Subcellular locations from

Jensen Localization Image for ABHD14B Gene COMPARTMENTS Subcellular localization image for ABHD14B gene
Compartment Confidence
nucleus 5
cytosol 3
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ABHD14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IDA 14672934
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ABHD14B: view

Pathways for ABHD14B Gene

SuperPathways for ABHD14B Gene

No Data Available

Interacting Proteins for ABHD14B Gene

Gene Ontology (GO) - Biological Process for ABHD14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 14672934
genes like me logo Genes that share ontologies with ABHD14B: view

No data available for Pathways by source for ABHD14B Gene

Transcripts for ABHD14B Gene

Unigene Clusters for ABHD14B Gene

Abhydrolase domain containing 14B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABHD14B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD14B Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: -
SP2: - -
SP3: -
SP4: - - -
SP5: -

Relevant External Links for ABHD14B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ABHD14B Gene

mRNA expression in normal human tissues for ABHD14B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ABHD14B Gene

This gene is overexpressed in Liver, secretome (9.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABHD14B Gene

SOURCE GeneReport for Unigene cluster for ABHD14B Gene Hs.420796

mRNA Expression by UniProt/SwissProt for ABHD14B Gene

Tissue specificity: Ubiquitous. Detected in spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocyte, heart, placenta, lung, liver, skeletal muscle, pancreas and kidney.
genes like me logo Genes that share expressions with ABHD14B: view

Expression partners for ABHD14B Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ABHD14B Gene

Orthologs for ABHD14B Gene

This gene was present in the common ancestor of animals.

Orthologs for ABHD14B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ABHD14B 35
  • 91.47 (n)
  • 91.3 (a)
ABHD14B 36
  • 90 (a)
(Canis familiaris)
Mammalia ABHD14B 35
  • 89.21 (n)
  • 88.89 (a)
ABHD14B 36
  • 88 (a)
(Mus musculus)
Mammalia Abhd14b 35
  • 87.6 (n)
  • 88.41 (a)
Abhd14b 16
Abhd14b 36
  • 87 (a)
(Pan troglodytes)
Mammalia ABHD14B 35
  • 99.21 (n)
  • 98.57 (a)
ABHD14B 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Abhd14b 35
  • 86.15 (n)
  • 87.44 (a)
(Monodelphis domestica)
Mammalia ABHD14B 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia ABHD14B 36
  • 66 (a)
(Anolis carolinensis)
Reptilia ABHD14B 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd14b 35
  • 62.98 (n)
  • 61.54 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68600 35
(Danio rerio)
Actinopterygii abhd14b 35
  • 65.06 (n)
  • 62.5 (a)
zgc64031 35
abhd14b 36
  • 61 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9461 35
(Caenorhabditis elegans)
Secernentea Y55F3AM.10 35
  • 46.83 (n)
  • 35 (a)
Y55F3AM.10 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
CSA.1288 36
  • 29 (a)
Species with no ortholog for ABHD14B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABHD14B Gene

Gene Tree for ABHD14B (if available)
Gene Tree for ABHD14B (if available)

Paralogs for ABHD14B Gene

Paralogs for ABHD14B Gene

Selected SIMAP similar genes for ABHD14B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ABHD14B: view

Variants for ABHD14B Gene

Sequence variations from dbSNP and Humsavar for ABHD14B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs379462 -- 51,970,301(+) TTCCT(A/G)TAACA intron-variant
rs745740 -- 51,970,402(-) TACTG(C/G)TGGGG intron-variant
rs4687793 -- 51,969,872(+) CCCAG(A/G)TGAGG intron-variant
rs11926611 -- 51,972,389(+) acatg(A/C)agaaa intron-variant
rs34359997 -- 51,970,054(+) ACATG(-/C)CCACT reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for ABHD14B Gene

Variant ID Type Subtype PubMed ID
nsv520211 CNV Gain 19592680
nsv508922 CNV Insertion 20534489
nsv876780 CNV Loss 21882294
dgv5134n71 CNV Loss 21882294
dgv5135n71 CNV Loss 21882294
nsv519445 CNV Gain+Loss 19592680

Relevant External Links for ABHD14B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABHD14B Gene

Disorders for ABHD14B Gene

No disorders were found for ABHD14B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ABHD14B Gene

Publications for ABHD14B Gene

  1. Purification, crystallization and preliminary X-ray crystallographic analysis of human CCG1-interacting factor B. (PMID: 11053859) Padmanabhan B. … Horikoshi M. (Acta Crystallogr. D 2000) 3 4 23
  2. The crystal structure of CCG1/TAF(II)250-interacting factor B (CIB). (PMID: 14672934) Padmanabhan B. … Horikoshi M. (J. Biol. Chem. 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3

Products for ABHD14B Gene

Sources for ABHD14B Gene

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