ABHD14B Gene
protein-coding GIFtS: 45
GCID: GC03M052003
|
|
abhydrolase domain containing 14B
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Aliases for ABHD14B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Abhydrolase Domain Containing 14B1 2 | | Cell Cycle Gene 1-Interacting Factor B2 | | CIB1 2 3 | | EC 3.-.-.-3 | | Abhydrolase Domain-Containing Protein 14B2 3 | | EC 3.1.11.68 | | CCG1-Interacting Factor B2 3 | | EC 3.1.21.48 | | MGC154291 | | |
Export aliases for ABHD14B gene to outside databasesPrevious GC identifer: GC03M051978 |
Summaries for ABHD14B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: ABHEB_HUMAN, Q96IU4Function: Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription
|
Genomic Views for ABHD14B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ABHD14B gene promoter: PPAR-alpha MAZR MIF-1 HNF-4alpha2 HNF-4alpha1 Other transcription factors
Search SABiosciences Chromatin IP Primers for ABHD14B
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABHD14B |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.2 Ensembl cytogenetic band: 3p21.2 HGNC cytogenetic band: 3p21.2ABHD14B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M052003: view genomic region
(about GC identifiers)
Start:
|
52,002,526 bp from pter |
End:
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52,017,425 bp from pter |
Size:
|
14,900 bases |
Orientation:
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minus strand |
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Proteins for ABHD14B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ABHEB_HUMAN, Q96IU4 (See
protein sequence)Recommended Name: Alpha/beta hydrolase domain-containing protein 14B Size: 210 amino acids; 22346 Da
Subunit: May interact with TAF1
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic
Sequence caution: Sequence=AAH50650.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for ABHD14B:1IMJ (3D)
 
Secondary accessions: Q86VK8 Q8N8W5Alternative splicing: 2 isoforms: Q96IU4-1 Q96IU4-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ABHD14B: NX_Q96IU4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96IU4 2 DME Specific Peptides for ABHD14B (Q96IU4)
ABHD14B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001139786.1 NP_001241682.1 NP_116139.1 ENSEMBL proteins: ENSP00000420065 ENSP00000378455 ENSP00000354841 ENSP00000417564 ENSP00000433388 ENSP00000318248 Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ABHD14B for ontologies About GeneDecksing
ABHD14B Antibody Products: Assay Products for ABHD14B: |
Protein
Domains / Families for ABHD14B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ABHD14B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96IU4ProtoNet protein and cluster: Q96IU4 UniProtKB/Swiss-Prot: ABHEB_HUMAN, Q96IU4Similarity: Belongs to the AB hydrolase superfamily. ABHD14 family |
Function for ABHD14B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: ABHEB_HUMAN, Q96IU4Function: Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcriptionEnzyme Numbers (IUBMB): EC 3.1.11.62 EC 3.-.-.-1 EC 3.1.21.42
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD14B (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD14B (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ABHD14B (NM_032750) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ABHD14B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABHD14B  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABHD14B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016787 | hydrolase activity |
IEA | -- |
ABHD14B for ontologies About GeneDecksing
|
Pathways & Interactions for ABHD14B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ABHD14B
5/12 Interacting proteins for ABHD14B (Q96IU43) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
|
Drugs & Compounds for ABHD14B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for ABHD14B Search CenterWatch for drugs/clinical trials and news about ABHD14B / ABHEB 
|
Transcripts for ABHD14B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ABHD14B gene (3 alternative transcripts): NM_001146314.1 NM_001254753.1 NM_032750.2 Unigene Cluster for ABHD14B: Abhydrolase domain containing 14B Hs.420796 [show with all ESTs]Unigene Representative Sequence: AK0921528 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000483233(uc003dcn.3) ENST00000487005(uc021wza.1) ENST00000395008 ENST00000361143 ENST00000461108(uc011bdz.1) ENST00000525795 ENST00000473912 ENST00000315877(uc003dcm.3 uc011bdy.2)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD14B (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD14B (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ABHD14B (NM_032750) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ABHD14B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABHD14B  |
Additional cDNA sequence: AK075112.1 AK092152.1 AK096073.1 AK296599.1 AK298022.1 BC007234.1 BC050650.1 BC056411.1 BC071931.1 24 DOTS entries: DT.100661294 DT.417058 DT.100885790 DT.100885783 DT.120854074 DT.95271097 DT.97862503 DT.100885787 DT.100885781 DT.100031651 DT.100650642 DT.100832089 DT.120854259 DT.92045901 DT.97856310 DT.92440367 DT.95271093 DT.100031650 DT.100885771 DT.100885775 DT.86856152 DT.97862501 DT.100885792 DT.450006 24/2592 AceView cDNA sequences (see all 2592): CB122518 BM457081 BQ064695 CA420940 BF725855 BU075629 BI030277 BG575376 BQ063337 CD699559 AA419127 BU944019 BM686170 BM851152 BF727394 BE876558 AI186597 BM011523 BU539239 BM762749 CK430638 CB128852 BF726119 BC008926 GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ABHD14B About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for ABHD14B
|
Expression for ABHD14B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ABHD14B expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image See ABHD14B Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ABHD14B
SOURCE GeneReport for Unigene cluster: Hs.420796 UniProtKB/Swiss-Prot: ABHEB_HUMAN, Q96IU4Tissue specificity: Ubiquitous. Detected in spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheralblood leukocyte, heart, placenta, lung, liver, skeletal muscle, pancreas and kidney SABiosciences Custom PCR Arrays for ABHD14B
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABHD14B Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ABHD14B | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABHD14B | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABHD14B | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABHD14B |
Orthologs for ABHD14B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ABHD14B gene from 4/17 species (see all 17) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
lizard (Anolis carolinensis) |
Reptilia |
ABHD14B6 |
-- |
64(a) |
1 ↔ 1 |
2(153053981-153059233) |
African clawed frog (Xenopus laevis) |
Amphibia |
MGC686002 |
hypothetical protein MGC68600 |
72.1(n) |
  |
BC056661.1 |
zebrafish (Danio rerio) |
Actinopterygii |
zgc640312 |
hypothetical protein MGC64031 |
74.95(n) |
  |
393338 BC053212.1 |
worm (Caenorhabditis elegans) |
Secernentea |
Y55F3AM.106 |
Protein Y55F3AM.10 |
28(a) |
1 → many |
IV(1027754-1030024) |
ENSEMBL Gene Tree for ABHD14B (if available) TreeFam Gene Tree for ABHD14B (if available)  |
Paralogs for ABHD14B gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ABHD14B gene
- ABHD14A2
1 SIMAP similar gene for ABHD14B using alignment to 3 protein entries: ABHEB_HUMAN (see all proteins):ABHD14A
ABHD14B for paralogs About GeneDecksing
|
Genomic Variants for ABHD14B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 3 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for ABHD14B (52002526 - 52017425 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ABHD14B: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABHD14B |
|
Disorders
/ Diseases for ABHD14B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ABHD14B for disorders About GeneDecksing
1 disease for ABHD14B: About MalaCardsprostatitis Export disorders for ABHD14B gene to outside databases
|
Publications for ABHD14B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ABHD14B gene, integrated from 9 sources (see all 11): (articles sorted by number of sources associating them with ABHD14B) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Purification, crystallization and preliminary X-ray crystallographic analysis of human CCG1-interacting factor B. (PubMed id 11053859)1, 2, 9 Padmanabhan B.... Horikoshi M. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (2005)
- The crystal structure of CCG1/TAF(II)250-interacting factor B (CIB). (PubMed id 14672934)2 Padmanabhan B.... Horikoshi M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ABHD14B gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ABHD14B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ABHD14B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ABHD14B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ABHD14B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ABHD14B gene: Search GeneIP for patents involving ABHD14B
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ABHD14B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ABHD14B | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABHD14B | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABHD14B | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABHD14B | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABHD14B | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABHD14B |
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 | | ABHD14B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABHD14B |
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