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Aliases for ABHD14B Gene

Aliases for ABHD14B Gene

  • Abhydrolase Domain Containing 14B 2 3 5
  • Alpha/Beta Hydrolase Domain-Containing Protein 14B 3 4
  • Abhydrolase Domain-Containing Protein 14B 3 4
  • CCG1-Interacting Factor B 3 4
  • CIB 3 4
  • Cell Cycle Gene 1-Interacting Factor B 3
  • Epididymis Secretory Protein Li 299 3
  • EC 3.1.21.4 63
  • EC 3.1.11.6 63
  • EC 3.-.-.- 4
  • HEL-S-299 3

External Ids for ABHD14B Gene

Previous GeneCards Identifiers for ABHD14B Gene

  • GC03M051978

Summaries for ABHD14B Gene

GeneCards Summary for ABHD14B Gene

ABHD14B (Abhydrolase Domain Containing 14B) is a Protein Coding gene. Among its related pathways are Phase II conjugation and Metabolism. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is ABHD14A.

UniProtKB/Swiss-Prot for ABHD14B Gene

  • Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD14B Gene

Genomics for ABHD14B Gene

Regulatory Elements for ABHD14B Gene

Enhancers for ABHD14B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ABHD14B on UCSC Golden Path with GeneCards custom track

Promoters for ABHD14B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ABHD14B on UCSC Golden Path with GeneCards custom track

Genomic Location for ABHD14B Gene

Chromosome:
3
Start:
51,968,510 bp from pter
End:
51,983,409 bp from pter
Size:
14,900 bases
Orientation:
Minus strand

Genomic View for ABHD14B Gene

Genes around ABHD14B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABHD14B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABHD14B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD14B Gene

Proteins for ABHD14B Gene

  • Protein details for ABHD14B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IU4-ABHEB_HUMAN
    Recommended name:
    Protein ABHD14B
    Protein Accession:
    Q96IU4
    Secondary Accessions:
    • Q86VK8
    • Q8N8W5

    Protein attributes for ABHD14B Gene

    Size:
    210 amino acids
    Molecular mass:
    22346 Da
    Quaternary structure:
    • May interact with TAF1.
    SequenceCaution:
    • Sequence=AAH50650.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ABHD14B Gene

    Alternative splice isoforms for ABHD14B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABHD14B Gene

Proteomics data for ABHD14B Gene at MOPED

Selected DME Specific Peptides for ABHD14B Gene

Post-translational modifications for ABHD14B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ABHD14B Gene

Antibody Products

Domains & Families for ABHD14B Gene

Gene Families for ABHD14B Gene

Protein Domains for ABHD14B Gene

Graphical View of Domain Structure for InterPro Entry

Q96IU4

UniProtKB/Swiss-Prot:

ABHEB_HUMAN :
  • Belongs to the AB hydrolase superfamily. ABHD14 family.
Family:
  • Belongs to the AB hydrolase superfamily. ABHD14 family.
genes like me logo Genes that share domains with ABHD14B: view

Function for ABHD14B Gene

Molecular function for ABHD14B Gene

UniProtKB/Swiss-Prot Function:
Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription.

Enzyme Numbers (IUBMB) for ABHD14B Gene

Gene Ontology (GO) - Molecular Function for ABHD14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14672934
genes like me logo Genes that share ontologies with ABHD14B: view
genes like me logo Genes that share phenotypes with ABHD14B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ABHD14B

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABHD14B Gene

Localization for ABHD14B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABHD14B Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABHD14B Gene COMPARTMENTS Subcellular localization image for ABHD14B gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ABHD14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ABHD14B: view

Pathways & Interactions for ABHD14B Gene

genes like me logo Genes that share pathways with ABHD14B: view

Pathways by source for ABHD14B Gene

Interacting Proteins for ABHD14B Gene

Gene Ontology (GO) - Biological Process for ABHD14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 14672934
genes like me logo Genes that share ontologies with ABHD14B: view

No data available for SIGNOR curated interactions for ABHD14B Gene

Drugs & Compounds for ABHD14B Gene

No Compound Related Data Available

Transcripts for ABHD14B Gene

Unigene Clusters for ABHD14B Gene

Abhydrolase domain containing 14B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD14B Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: -
SP2: - -
SP3: -
SP4: - - -
SP5: -

Relevant External Links for ABHD14B Gene

GeneLoc Exon Structure for
ABHD14B
ECgene alternative splicing isoforms for
ABHD14B

Expression for ABHD14B Gene

mRNA expression in normal human tissues for ABHD14B Gene

Protein differential expression in normal tissues from HIPED for ABHD14B Gene

This gene is overexpressed in Liver, secretome (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ABHD14B Gene



SOURCE GeneReport for Unigene cluster for ABHD14B Gene Hs.420796

mRNA Expression by UniProt/SwissProt for ABHD14B Gene

Q96IU4-ABHEB_HUMAN
Tissue specificity: Ubiquitous. Detected in spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocyte, heart, placenta, lung, liver, skeletal muscle, pancreas and kidney.
genes like me logo Genes that share expression patterns with ABHD14B: view

Protein tissue co-expression partners for ABHD14B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ABHD14B Gene

Orthologs for ABHD14B Gene

This gene was present in the common ancestor of animals.

Orthologs for ABHD14B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ABHD14B 35
  • 91.47 (n)
  • 91.3 (a)
ABHD14B 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABHD14B 35
  • 89.21 (n)
  • 88.89 (a)
ABHD14B 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abhd14b 35
  • 87.6 (n)
  • 88.41 (a)
Abhd14b 16
Abhd14b 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ABHD14B 35
  • 99.21 (n)
  • 98.57 (a)
ABHD14B 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abhd14b 35
  • 86.15 (n)
  • 87.44 (a)
oppossum
(Monodelphis domestica)
Mammalia ABHD14B 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABHD14B 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABHD14B 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd14b 35
  • 62.98 (n)
  • 61.54 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68600 35
zebrafish
(Danio rerio)
Actinopterygii abhd14b 35
  • 65.06 (n)
  • 62.5 (a)
zgc64031 35
abhd14b 36
  • 61 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9461 35
worm
(Caenorhabditis elegans)
Secernentea Y55F3AM.10 35
  • 46.83 (n)
  • 35 (a)
Y55F3AM.10 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
ManyToMany
CSA.1288 36
  • 29 (a)
ManyToMany
Species with no ortholog for ABHD14B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABHD14B Gene

ENSEMBL:
Gene Tree for ABHD14B (if available)
TreeFam:
Gene Tree for ABHD14B (if available)

Paralogs for ABHD14B Gene

Paralogs for ABHD14B Gene

(1) SIMAP similar genes for ABHD14B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ABHD14B: view

Variants for ABHD14B Gene

Sequence variations from dbSNP and Humsavar for ABHD14B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs745740 -- 51,970,402(-) TACTG(C/G)TGGGG intron-variant
rs379462 -- 51,970,301(+) TTCCT(A/G)TAACA intron-variant
rs58223457 -- 51,971,879(+) GGGGC(C/T)TCAGC intron-variant, utr-variant-5-prime
rs4687793 -- 51,969,872(+) CCCAG(A/G)TGAGG intron-variant
rs34359997 -- 51,970,054(+) ACATG(-/C)CCACT reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for ABHD14B Gene

Variant ID Type Subtype PubMed ID
nsv520211 CNV Gain 19592680
nsv508922 CNV Insertion 20534489
nsv876780 CNV Loss 21882294
dgv5134n71 CNV Loss 21882294
dgv5135n71 CNV Loss 21882294
nsv519445 CNV Gain+Loss 19592680

Variation tolerance for ABHD14B Gene

Residual Variation Intolerance Score: 76.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.59; 44.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABHD14B Gene

HapMap Linkage Disequilibrium report
ABHD14B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABHD14B Gene

Disorders for ABHD14B Gene

Relevant External Links for ABHD14B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABHD14B

No disorders were found for ABHD14B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABHD14B Gene

Publications for ABHD14B Gene

  1. Purification, crystallization and preliminary X-ray crystallographic analysis of human CCG1-interacting factor B. (PMID: 11053859) Padmanabhan B. … Horikoshi M. (Acta Crystallogr. D 2000) 3 4 23 67
  2. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3

Products for ABHD14B Gene

Sources for ABHD14B Gene

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