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Aliases for ABHD14A-ACY1 Gene

Aliases for ABHD14A-ACY1 Gene

  • ABHD14A-ACY1 Readthrough 2 3 5
  • ABHD14A-ACY1 Readthrough (NMD Candidate) 2

External Ids for ABHD14A-ACY1 Gene

Previous GeneCards Identifiers for ABHD14A-ACY1 Gene

  • GC03U901707
  • GC03M051997
  • GC03P052012

Summaries for ABHD14A-ACY1 Gene

Entrez Gene Summary for ABHD14A-ACY1 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring abhydrolase domain containing 14A (ABHD14A) and aminoacylase 1 (ACY1) genes on chromosome 3. The read-through transcript encodes a protein that shares sequence identity with the downstream gene product but its N-terminal region is distinct due to the use of an alternate start codon relative to the upstream gene. [provided by RefSeq, Oct 2015]

GeneCards Summary for ABHD14A-ACY1 Gene

ABHD14A-ACY1 (ABHD14A-ACY1 Readthrough) is a Protein Coding gene. Among its related pathways are Arginine biosynthesis and Metabolism. GO annotations related to this gene include hydrolase activity and aminoacylase activity. An important paralog of this gene is ACY1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD14A-ACY1 Gene

Genomics for ABHD14A-ACY1 Gene

Regulatory Elements for ABHD14A-ACY1 Gene

Enhancers for ABHD14A-ACY1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F052108 1.4 FANTOM5 Ensembl ENCODE 11.1 +134.8 134764 2.9 HDGF CTCF SIN3A ARID4B RAD21 NCOR1 SCRT2 ZNF143 SMC3 ZNF207 DUSP7 ABHD14B ABHD14A PCBP4 ABHD14A-ACY1 GPR62 GLYCTK WDR82 MIR135A1 GLYCTK-AS1
GH03F052153 1.1 ENCODE 10.5 +179.8 179760 2.6 PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 DUSP7 ABHD14A-ACY1 ABHD14B PCBP4 ACY1 WDR82 GPR62 PBRM1 POC1A LINC00696
GH03F051794 0.4 ENCODE 9.6 -180.3 -180337 0.2 TEAD4 IQCF3 IQCF4 IQCF5 ABHD14A-ACY1 ABHD14B PCBP4 ABHD14A GC03P051793
GH03F051973 1.1 ENCODE 0.8 +0.4 435 3.8 HDGF CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 ZNF143 PARP3 NT5DC2 ABHD14A-ACY1 ACY1
GH03F051977 0.2 ENCODE 0.8 +2.9 2894 0.2 ABHD14A-ACY1 ACY1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ABHD14A-ACY1 on UCSC Golden Path with GeneCards custom track

Promoters for ABHD14A-ACY1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001364097 594 1001 ELF3 HDGF SIN3A NFXL1 ZBTB40 EGR2 THAP11 SP5 REST SMARCA4

Genomic Location for ABHD14A-ACY1 Gene

Chromosome:
3
Start:
51,974,706 bp from pter
End:
51,989,202 bp from pter
Size:
14,497 bases
Orientation:
Plus strand

Genomic View for ABHD14A-ACY1 Gene

Genes around ABHD14A-ACY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABHD14A-ACY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABHD14A-ACY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD14A-ACY1 Gene

Proteins for ABHD14A-ACY1 Gene

  • Protein details for ABHD14A-ACY1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A1B0GU64
    Recommended name:
    Protein ABHD14A-ACY1
    Protein Accession:
    A0A1B0GU64

    Protein attributes for ABHD14A-ACY1 Gene

    Size:
    138 amino acids
    Molecular mass:
    14863 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ABHD14A-ACY1 Gene

Post-translational modifications for ABHD14A-ACY1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ABHD14A-ACY1 Gene

Domains & Families for ABHD14A-ACY1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ABHD14A-ACY1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ABHD14A-ACY1 Gene

Function for ABHD14A-ACY1 Gene

Gene Ontology (GO) - Molecular Function for ABHD14A-ACY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IBA --
GO:0016787 hydrolase activity IEA --
GO:0070573 metallodipeptidase activity IBA --
genes like me logo Genes that share ontologies with ABHD14A-ACY1: view

Phenotypes for ABHD14A-ACY1 Gene

GenomeRNAi human phenotypes for ABHD14A-ACY1:
genes like me logo Genes that share phenotypes with ABHD14A-ACY1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABHD14A-ACY1 Gene

Localization for ABHD14A-ACY1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABHD14A-ACY1 gene
Compartment Confidence
extracellular 3
plasma membrane 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ABHD14A-ACY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ABHD14A-ACY1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ABHD14A-ACY1 Gene

Pathways & Interactions for ABHD14A-ACY1 Gene

genes like me logo Genes that share pathways with ABHD14A-ACY1: view

Pathways by source for ABHD14A-ACY1 Gene

Interacting Proteins for ABHD14A-ACY1 Gene

Gene Ontology (GO) - Biological Process for ABHD14A-ACY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006520 cellular amino acid metabolic process IEA --
GO:0008152 metabolic process IEA --
GO:0043171 peptide catabolic process IBA --
genes like me logo Genes that share ontologies with ABHD14A-ACY1: view

No data available for SIGNOR curated interactions for ABHD14A-ACY1 Gene

Transcripts for ABHD14A-ACY1 Gene

mRNA/cDNA for ABHD14A-ACY1 Gene

(1) REFSEQ mRNAs :
(29) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD14A-ACY1 Gene

No ASD Table

Relevant External Links for ABHD14A-ACY1 Gene

GeneLoc Exon Structure for
ABHD14A-ACY1
ECgene alternative splicing isoforms for
ABHD14A-ACY1

Expression for ABHD14A-ACY1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ABHD14A-ACY1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from PaxDb, MaxQB, and MOPED for ABHD14A-ACY1 Gene



genes like me logo Genes that share expression patterns with ABHD14A-ACY1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ABHD14A-ACY1 Gene

Orthologs for ABHD14A-ACY1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ABHD14A-ACY1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABHD14A-ACY1 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 83 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Acy1 35
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 74 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 70 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ACY1 35
  • 68 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 65 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 61 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii acy1 35
  • 56 (a)
ManyToMany
CU896698.1 35
  • 56 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6465 35
  • 46 (a)
ManyToMany
CG17110 35
  • 45 (a)
ManyToMany
CG6726 35
  • 45 (a)
ManyToMany
CG6733 35
  • 42 (a)
ManyToMany
CG6738 35
  • 42 (a)
ManyToMany
CG17109 35
  • 41 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C10C5.5 35
  • 45 (a)
ManyToMany
C06A6.4 35
  • 44 (a)
ManyToMany
C10C5.3 35
  • 44 (a)
ManyToMany
C10C5.4 35
  • 44 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8209 35
  • 48 (a)
OneToMany
Species where no ortholog for ABHD14A-ACY1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ABHD14A-ACY1 Gene

ENSEMBL:
Gene Tree for ABHD14A-ACY1 (if available)
TreeFam:
Gene Tree for ABHD14A-ACY1 (if available)

Paralogs for ABHD14A-ACY1 Gene

Paralogs for ABHD14A-ACY1 Gene

(2) SIMAP similar genes for ABHD14A-ACY1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ABHD14A-ACY1: view

Variants for ABHD14A-ACY1 Gene

Sequence variations from dbSNP and Humsavar for ABHD14A-ACY1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs121912698 Pathogenic 51,988,821(+) ATATC(C/T)GCGCG reference, missense
rs121912699 Pathogenic 51,987,188(+) AAGGA(A/C)TGGCA intron-variant, reference, missense
rs121912700 Pathogenic 51,986,993(+) GGGTG(C/T)GGGTT reference, missense
rs121912701 Pathogenic 51,989,026(+) TACAC(A/G)CCTGC reference, missense
rs387906579 Pathogenic 51,988,953(+) CACAC(-/AC)CTGTG reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for ABHD14A-ACY1 Gene

Variant ID Type Subtype PubMed ID
nsv1003453 CNV gain 25217958
nsv508922 CNV insertion 20534489
nsv519445 CNV gain+loss 19592680
nsv520211 CNV gain 19592680
nsv954857 CNV deletion 24416366

Variation tolerance for ABHD14A-ACY1 Gene

Gene Damage Index Score: 2.94; 49.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABHD14A-ACY1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABHD14A-ACY1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABHD14A-ACY1 Gene

Disorders for ABHD14A-ACY1 Gene

Relevant External Links for ABHD14A-ACY1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABHD14A-ACY1

No disorders were found for ABHD14A-ACY1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABHD14A-ACY1 Gene

Publications for ABHD14A-ACY1 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64

Products for ABHD14A-ACY1 Gene

Sources for ABHD14A-ACY1 Gene

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