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ABHD14A-ACY1 Gene

protein-coding   GIFtS: 22
GCID: GC03P052012

ABHD14A-ACY1 Readthrough (NMD Candidate)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ABHD14A-ACY1 Readthrough (NMD Candidate)1 2

External Ids:    HGNC: 388561   Entrez Gene: 1005267602   Ensembl: ENSG000001147867   UniProtKB: C9JMV94   UniProtKB: F2Z3Q04   

Export aliases for ABHD14A-ACY1 gene to outside databases

Previous GC identifers: GC03U901707 GC03M051997


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ABHD14A-ACY1 Gene:
This locus represents naturally occurring read-through transcription between the neighboring abhydrolase domain
containing 14A (ABHD14A) and aminoacylase 1 (ACY1) genes on chromosome 3. The read-through transcript is a
candidate for nonsense-mediated mRNA decay (NMD) and is unlikely to be protein-coding. (provided by RefSeq, Nov
2010)

GeneCards Summary for ABHD14A-ACY1 Gene:
ABHD14A-ACY1 (ABHD14A-ACY1 readthrough (NMD candidate)) is a protein-coding gene. An important paralog of this gene is ACY1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for ABHD14A-ACY1
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ABHD14A-ACY1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p   Ensembl cytogenetic band:  3p21.2   HGNC cytogenetic band: 3p21.2

ABHD14A-ACY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABHD14A-ACY1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P052012:  view genomic region     (about GC identifiers)

Start:
52,009,042 bp from pter      End:
52,023,218 bp from pter
Size:
14,177 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
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UniProtKB/TrEMBL: C9JMV9 (See protein sequence)
Recommended Name: Protein ABHD14A-ACY1  
Size: 509 amino acids; 56436 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: F2Z3Q0 (See protein sequence)

Recommended Name: Protein ABHD14A-ACY1  
Size: 167 amino acids; 17846 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

Explore proteomics data for ABHD14A-ACY1 at MOPED


See ABHD14A-ACY1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


ENSEMBL proteins: 
 ENSP00000420395   ENSP00000417688   ENSP00000420487  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR011650 Peptidase_M20_dimer
 IPR001261 ArgE/DapE_CS
 IPR002933 Peptidase_M20
 IPR010159 N-acyl_aa_amidohydrolase

Graphical View of Domain Structure for InterPro Entry C9JMV9
Graphical View of Domain Structure for InterPro Entry F2Z3Q0

ProtoNet protein and cluster: C9JMV9


Find genes that share domains with ABHD14A-ACY1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004046aminoacylase activity ----
GO:0008237metallopeptidase activity ----
GO:0016787hydrolase activity ----
     
Find genes that share ontologies with ABHD14A-ACY1           About GenesLikeMe


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm ----

Find genes that share ontologies with ABHD14A-ACY1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

    Search GeneGlobe Interaction Network for ABHD14A-ACY1

Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006508proteolysis ----
GO:0006520cellular amino acid metabolic process ----
GO:0008152metabolic process ----

Find genes that share ontologies with ABHD14A-ACY1           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000486081 ENST00000463721(uc011bea.2) ENST00000497128 ENST00000463937

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GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for ABHD14A-ACY1 (see all 12)    About this scheme

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a ·
SP1:                                      -     -                                                                                               -               
SP2:                                      -     -                                                                                               -               
SP3:                                      -     -     -     -                                                                                   -               
SP4:                                      -     -     -     -     -                                                                             -               
SP5:                                      -     -                                   -     -     -                                               -               

ExUns: 15b · 15c · 15d
SP1:                  
SP2:                  
SP3:                  
SP4:                  
SP5:                  


ECgene alternative splicing isoforms for ABHD14A-ACY1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ABHD14A-ACY1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
ABHD14A-ACY1 Expression
About this image

ABHD14A-ACY1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ABHD14A-ACY1 Protein Expression
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for ABHD14A-ACY1 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
65(a)
1 → many
12(3126676-3130439)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
61(a)
1 → many
2(153097000-153119597)
zebrafish
(Danio rerio)
Actinopterygii CU896698.16
acy16
aminoacylase 1
56(a)
56(a)
many ↔ many
many ↔ many
22(39623589-39632809) ENSDARG00000004845
22(39637504-39656460) ENSDARG00000038475
fruit fly
(Drosophila melanogaster)
Insecta CG64656
CG171106
(see all 6)
--
46(a)
45(a)
(see all 6)
many ↔ many
many ↔ many
(see all 6)
3R(6501281-6502892)
3R(18919220-18920906)
worm
(Caenorhabditis elegans)
Secernentea C10C5.56
C06A6.46
(see all 4)
Protein C10C5.5 (C10C5.5) mRNA, complete cds
Protein C06A6.4, isoform a (C06A6.4) mRNA, complet...
(see all 4)
45(a)
44(a)
(see all 4)
many ↔ many
many ↔ many
(see all 4)
IV(9381421-9383115) WBGene00007509
IV(7826328-7829301) WBGene00015509
        Species with no ortholog for ABHD14A-ACY1

ENSEMBL Gene Tree for ABHD14A-ACY1 (if available)
TreeFam Gene Tree for ABHD14A-ACY1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ABHD14A-ACY1 gene
ACY12  
2 SIMAP similar genes for ABHD14A-ACY1 using alignment to 2 protein entries:     C9JMV9_HUMAN (see all proteins):
ACY1    ABHD14A

Find genes that share paralogs with ABHD14A-ACY1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Structural Variations
     Database of Genomic Variants (DGV) 6 variations for ABHD14A-ACY1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv508922CNV Insertion20534489
dgv5134n71CNV Loss21882294
nsv876780CNV Loss21882294
dgv5135n71CNV Loss21882294
nsv520211CNV Gain19592680
nsv519445CNV Gain+Loss19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed article for ABHD14A-ACY1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ABHD14A-ACY1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (PLoS ONE 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 100526760 HGNC: 38856 Ensembl:ENSG00000114786 euGenes: HUgn100526760 ECgene: ABHD14A-ACY1
H-InvDB: ABHD14A-ACY1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ABHD14A-ACY1 gene:
Search GeneIP for patents involving ABHD14A-ACY1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Search for Antibodies for ABHD14A-ACY1 at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for ABHD14A-ACY1
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 Browse ESI BIO Cell Lines and PureStem Progenitors for ABHD14A-ACY1
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 Browse SwitchGear 3'UTR luciferase reporter plasmids for ABHD14A-ACY1
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 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ABHD14A-ACY1
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ABHD14A-ACY1
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ABHD14A-ACY1
 Search LSBio for Antibodies for ABHD14A-ACY1
Customized transgenic rodents for:
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 Search Addgene for plasmids for ABHD14A-ACY1
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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