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Aliases for ABHD14A-ACY1 Gene

Aliases for ABHD14A-ACY1 Gene

  • ABHD14A-ACY1 Readthrough 2 3 5
  • ABHD14A-ACY1 Readthrough (NMD Candidate) 2

External Ids for ABHD14A-ACY1 Gene

Previous GeneCards Identifiers for ABHD14A-ACY1 Gene

  • GC03U901707
  • GC03M051997
  • GC03P052012

Summaries for ABHD14A-ACY1 Gene

Entrez Gene Summary for ABHD14A-ACY1 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring abhydrolase domain containing 14A (ABHD14A) and aminoacylase 1 (ACY1) genes on chromosome 3. The read-through transcript encodes a protein that shares sequence identity with the downstream gene product but its N-terminal region is distinct due to the use of an alternate start codon relative to the upstream gene. [provided by RefSeq, Oct 2015]

GeneCards Summary for ABHD14A-ACY1 Gene

ABHD14A-ACY1 (ABHD14A-ACY1 Readthrough) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity and aminoacylase activity. An important paralog of this gene is ACY1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD14A-ACY1 Gene

Genomics for ABHD14A-ACY1 Gene

Regulatory Elements for ABHD14A-ACY1 Gene

Enhancers for ABHD14A-ACY1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ABHD14A-ACY1 on UCSC Golden Path with GeneCards custom track

Promoters for ABHD14A-ACY1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ABHD14A-ACY1 Gene

Chromosome:
3
Start:
51,974,706 bp from pter
End:
51,989,202 bp from pter
Size:
14,497 bases
Orientation:
Plus strand

Genomic View for ABHD14A-ACY1 Gene

Genes around ABHD14A-ACY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABHD14A-ACY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABHD14A-ACY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD14A-ACY1 Gene

Proteins for ABHD14A-ACY1 Gene

  • Protein details for ABHD14A-ACY1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    C9JMV9
    Recommended name:
    Protein ABHD14A-ACY1
    Protein Accession:
    C9JMV9

    Protein attributes for ABHD14A-ACY1 Gene

    Size:
    509 amino acids
    Molecular mass:
    56436 Da
    Quaternary structure:
    No Data Available
  • Protein details for ABHD14A-ACY1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    F2Z3Q0
    Recommended name:
    Protein ABHD14A-ACY1
    Protein Accession:
    F2Z3Q0

    Protein attributes for ABHD14A-ACY1 Gene

    Size:
    167 amino acids
    Molecular mass:
    17846 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ABHD14A-ACY1 Gene

Post-translational modifications for ABHD14A-ACY1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ABHD14A-ACY1 Gene

Domains & Families for ABHD14A-ACY1 Gene

Protein Domains for ABHD14A-ACY1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ABHD14A-ACY1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ABHD14A-ACY1 Gene

Function for ABHD14A-ACY1 Gene

Gene Ontology (GO) - Molecular Function for ABHD14A-ACY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008237 metallopeptidase activity IEA --
genes like me logo Genes that share ontologies with ABHD14A-ACY1: view

Phenotypes for ABHD14A-ACY1 Gene

GenomeRNAi human phenotypes for ABHD14A-ACY1:
genes like me logo Genes that share phenotypes with ABHD14A-ACY1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABHD14A-ACY1 Gene

Localization for ABHD14A-ACY1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABHD14A-ACY1 Gene COMPARTMENTS Subcellular localization image for ABHD14A-ACY1 gene
Compartment Confidence
extracellular 3
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ABHD14A-ACY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ABHD14A-ACY1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ABHD14A-ACY1 Gene

Pathways & Interactions for ABHD14A-ACY1 Gene

SuperPathways for ABHD14A-ACY1 Gene

No Data Available

Interacting Proteins for ABHD14A-ACY1 Gene

Gene Ontology (GO) - Biological Process for ABHD14A-ACY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006520 cellular amino acid metabolic process IEA --
genes like me logo Genes that share ontologies with ABHD14A-ACY1: view

No data available for Pathways by source and SIGNOR curated interactions for ABHD14A-ACY1 Gene

Drugs & Compounds for ABHD14A-ACY1 Gene

No Compound Related Data Available

Transcripts for ABHD14A-ACY1 Gene

mRNA/cDNA for ABHD14A-ACY1 Gene

(1) REFSEQ mRNAs :
(29) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD14A-ACY1 Gene

No ASD Table

Relevant External Links for ABHD14A-ACY1 Gene

GeneLoc Exon Structure for
ABHD14A-ACY1
ECgene alternative splicing isoforms for
ABHD14A-ACY1

Expression for ABHD14A-ACY1 Gene

mRNA expression in normal human tissues for ABHD14A-ACY1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from PaxDb, MaxQB, and MOPED for ABHD14A-ACY1 Gene



genes like me logo Genes that share expression patterns with ABHD14A-ACY1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ABHD14A-ACY1 Gene

Orthologs for ABHD14A-ACY1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ABHD14A-ACY1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACY1 35
  • 68 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 83 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 70 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Acy1 35
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 74 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ABHD14A-ACY1 35
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 65 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 61 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii acy1 35
  • 56 (a)
ManyToMany
CU896698.1 35
  • 56 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17109 35
  • 41 (a)
ManyToMany
CG17110 35
  • 45 (a)
ManyToMany
CG6465 35
  • 46 (a)
ManyToMany
CG6726 35
  • 45 (a)
ManyToMany
CG6733 35
  • 42 (a)
ManyToMany
CG6738 35
  • 42 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C06A6.4 35
  • 44 (a)
ManyToMany
C10C5.3 35
  • 44 (a)
ManyToMany
C10C5.4 35
  • 44 (a)
ManyToMany
C10C5.5 35
  • 45 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8209 35
  • 48 (a)
OneToMany
Species where no ortholog for ABHD14A-ACY1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ABHD14A-ACY1 Gene

ENSEMBL:
Gene Tree for ABHD14A-ACY1 (if available)
TreeFam:
Gene Tree for ABHD14A-ACY1 (if available)

Paralogs for ABHD14A-ACY1 Gene

Paralogs for ABHD14A-ACY1 Gene

(2) SIMAP similar genes for ABHD14A-ACY1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ABHD14A-ACY1: view

Variants for ABHD14A-ACY1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ABHD14A-ACY1 Gene

Variant ID Type Subtype PubMed ID
nsv1003453 CNV gain 25217958
nsv508922 CNV insertion 20534489
nsv519445 CNV gain+loss 19592680
nsv520211 CNV gain 19592680
nsv954857 CNV deletion 24416366

Variation tolerance for ABHD14A-ACY1 Gene

Gene Damage Index Score: 2.94; 49.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABHD14A-ACY1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABHD14A-ACY1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for ABHD14A-ACY1 Gene

Disorders for ABHD14A-ACY1 Gene

Relevant External Links for ABHD14A-ACY1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABHD14A-ACY1

No disorders were found for ABHD14A-ACY1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABHD14A-ACY1 Gene

Publications for ABHD14A-ACY1 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 65

Products for ABHD14A-ACY1 Gene

Sources for ABHD14A-ACY1 Gene

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