ABHD14A Gene
protein-coding GIFtS: 38
GCID: GC03P052005
|
|
abhydrolase domain containing 14A
| |
Aliases
for ABHD14A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Abhydrolase Domain Containing 14A1 2 | | DORZ11 2 | | Abhydrolase Domain-Containing Protein 14A2 3 | | DKFZP564O2431 | | EC 3.-.-.-3 |
Export aliases for ABHD14A gene to outside databasesPrevious GC identifer: GC03P051985 |
Summaries
for ABHD14A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ABHEA_HUMAN, Q9BUJ0Function: Possible role in granule neuron development (By similarity)
|
Genomic Views
for ABHD14A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ABHD14A gene promoter:
GR MZF-1 MAZR NRSF form 1 HNF-4alpha2 NRSF form 2 HNF-4alpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ABHD14A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABHD14A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.1 Ensembl cytogenetic band: 3p21.2 HGNC cytogenetic band: 3p21.1ABHD14A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P052005: view genomic region
(about GC identifiers)
Start:
|
52,005,442 bp from pter |
End:
|
52,015,216 bp from pter |
Size:
|
9,775 bases |
Orientation:
|
plus strand |
|
Proteins
for ABHD14A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ABHEA_HUMAN, Q9BUJ0 (See
protein sequence)Recommended Name: Alpha/beta hydrolase domain-containing protein 14A Size: 271 amino acids; 29765 Da
Subcellular location: Cytoplasm (By similarity). Membrane; Single-pass type II membrane protein (Potential)
Caution: It is uncertain whether Met-1 or Met-30 is the initiator
Sequence caution: Sequence=AAQ88568.1; Type=Erroneous initiation;
Secondary accessions: Q6UXU8 Q9Y3T7Explore the universe of human proteins at neXtProt for ABHD14A: NX_Q9BUJ0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BUJ0
ABHD14A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056222.2
ENSEMBL proteins: ENSP00000418242 ENSP00000420475 ENSP00000273596 ENSP00000418824
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
ABHD14A for ontologies About GeneDecksing
ABHD14A Antibody Products:
Assay Products for ABHD14A: |
Protein
Domains /
Families
for ABHD14A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9BUJ0 UniProtKB/Swiss-Prot: ABHEA_HUMAN, Q9BUJ0Similarity: Belongs to the AB hydrolase superfamily. ABHD14 family |
Function
for ABHD14A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ABHEA_HUMAN, Q9BUJ0Function: Possible role in granule neuron development (By similarity)Enzyme Number (IUBMB): EC 3.-.-.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD14A (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD14A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ABHD14A (NM_015407) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ABHD14A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABHD14A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABHD14A |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016787 | hydrolase activity |
IEA | -- |
ABHD14A for ontologies About GeneDecksing
|
Pathways & Interactions
for ABHD14A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ABHD14A
|
Drugs & Compounds
for ABHD14A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ABHD14A
Search CenterWatch for drugs/clinical trials and news about ABHD14A / ABHEA
|
Transcripts
for ABHD14A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ABHD14A gene: NM_015407.4 Unigene Cluster for ABHD14A: Abhydrolase domain containing 14A Hs.534400 [show with all ESTs]Unigene Representative Sequence: BM4667915 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000497864 ENST00000494478 ENST00000273596(uc003dco.3) ENST00000474575(uc010hlz.2)
ENST00000491470
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD14A (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD14A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ABHD14A (NM_015407) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ABHD14A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABHD14A |
Additional cDNA sequence: AL050015.1 AY358201.1 BC002571.2 17 DOTS entries: DT.86846444 DT.120854150 DT.100661294 DT.92420002 DT.100685918 DT.120854074 DT.95170238 DT.120854112 DT.100885790 DT.86846443 DT.95170239 DT.120854255 DT.97862503 DT.91658769 DT.100832089 DT.120854259 DT.417058 24/446 AceView cDNA sequences (see all 446): CA311304 BU542746 AU077016 CR622719 CB146530 BE795159 CB125500 CB154901 CR608049 CN480840 BU509544 BM924044 BQ918812 CR597055 BU731984 BG025960 CB115620 CD014024 CD014026 L07548 AW043909 BU540463 AW160796 BC000545
GeneLoc Exon Structure
|
Expression
for ABHD14A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ABHD14A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCTTGGACA
About this image
See ABHD14A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ABHD14A
SOURCE GeneReport for Unigene cluster: Hs.534400
SABiosciences Custom PCR Arrays for ABHD14A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABHD14A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ABHD14A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABHD14A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABHD14A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABHD14A |
Orthologs
for ABHD14A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ABHD14A gene from 5/14 species (see all 14) About this table
ENSEMBL Gene Tree for ABHD14A (if available)
TreeFam Gene Tree for ABHD14A (if available) |
Paralogs
for ABHD14A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ABHD14A gene
- ABHD14B2
2 SIMAP similar genes for ABHD14A using alignment to 4 protein entries: ABHEA_HUMAN (see all proteins):ABHD14A-ACY1 ABHD14B
ABHD14A for paralogs About GeneDecksing
|
Genomic Variants
for ABHD14A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ABHD14A (52005442 - 52015216 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ABHD14A: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for ABHD14A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ABHD14A for disorders About GeneDecksing
4  diseases for ABHD14A: About MalaCardsisovaleric acidemia viral hepatitis hepatitis neuronitis
1 disease from the University of Copenhagen DISEASES database for ABHD14A:Biotinidase deficiency Export disorders for ABHD14A gene to outside databases
|
Publications
for ABHD14A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ABHD14A gene integrated from 9 sources:
(articles sorted by number of sources associating them with ABHD14A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
- Dorz1, a novel gene expressed in differentiating cerebellar granule neurons, is down-regulated in Zic1-deficient mouse. (PubMed id 14667578)1 Hoshino J....Mikoshiba K. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for ABHD14A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ABHD14A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ABHD14A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ABHD14A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ABHD14A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ABHD14A gene:
Search GeneIP for patents involving ABHD14A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ABHD14A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ABHD14A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ABHD14A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABHD14A | | | OriGene Protein Over-expression Lysate for ABHD14A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ABHD14A | | OriGene 3'-UTR Clone for ABHD14A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD14A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD14A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ABHD14A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ABHD14A | | OriGene Custom Protein Services for ABHD14A | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ABHD14A | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABHD14A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABHD14A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABHD14A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABHD14A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABHD14A |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ABHD14A |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ABHD14A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABHD14A |
|  |  |  | | | | Search ThermoFisher Antibodies for ABHD14A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABHD14A |
|
|
|
|
