Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ABHD14A Gene

Aliases for ABHD14A Gene

  • Abhydrolase Domain Containing 14A 2 3 5
  • Alpha/Beta Hydrolase Domain-Containing Protein 14A 3 4
  • Abhydrolase Domain-Containing Protein 14A 3 4
  • EC 3.-.-.- 4
  • DORZ1 3

External Ids for ABHD14A Gene

Previous GeneCards Identifiers for ABHD14A Gene

  • GC03P051985
  • GC03P052005

Summaries for ABHD14A Gene

GeneCards Summary for ABHD14A Gene

ABHD14A (Abhydrolase Domain Containing 14A) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is ABHD14B.

UniProtKB/Swiss-Prot for ABHD14A Gene

  • Possible role in granule neuron development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD14A Gene

Genomics for ABHD14A Gene

Regulatory Elements for ABHD14A Gene

Enhancers for ABHD14A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ABHD14A on UCSC Golden Path with GeneCards custom track

Genomic Location for ABHD14A Gene

51,971,426 bp from pter
51,981,200 bp from pter
9,775 bases
Plus strand

Genomic View for ABHD14A Gene

Genes around ABHD14A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABHD14A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABHD14A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD14A Gene

Proteins for ABHD14A Gene

  • Protein details for ABHD14A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein ABHD14A
    Protein Accession:
    Secondary Accessions:
    • Q6UXU8
    • Q9Y3T7

    Protein attributes for ABHD14A Gene

    271 amino acids
    Molecular mass:
    29765 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ88568.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ABHD14A Gene

Proteomics data for ABHD14A Gene at MOPED

Post-translational modifications for ABHD14A Gene

  • Glycosylation at Asn 67 and Asn 201
  • Modification sites at PhosphoSitePlus

Other Protein References for ABHD14A Gene

No data available for DME Specific Peptides for ABHD14A Gene

Domains & Families for ABHD14A Gene

Gene Families for ABHD14A Gene

Protein Domains for ABHD14A Gene


Suggested Antigen Peptide Sequences for ABHD14A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AB hydrolase superfamily. ABHD14 family.
  • Belongs to the AB hydrolase superfamily. ABHD14 family.
genes like me logo Genes that share domains with ABHD14A: view

Function for ABHD14A Gene

Molecular function for ABHD14A Gene

UniProtKB/Swiss-Prot Function:
Possible role in granule neuron development.

Enzyme Numbers (IUBMB) for ABHD14A Gene

Phenotypes for ABHD14A Gene

MGI mutant phenotypes for ABHD14A:
inferred from 1 alleles
GenomeRNAi human phenotypes for ABHD14A:
genes like me logo Genes that share phenotypes with ABHD14A: view

Animal Models for ABHD14A Gene

MGI Knock Outs for ABHD14A:

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ABHD14A Gene

Localization for ABHD14A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABHD14A Gene

Cytoplasm. Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for ABHD14A Gene COMPARTMENTS Subcellular localization image for ABHD14A gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for ABHD14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with ABHD14A: view

Pathways & Interactions for ABHD14A Gene

SuperPathways for ABHD14A Gene

No Data Available

Interacting Proteins for ABHD14A Gene

Gene Ontology (GO) - Biological Process for ABHD14A Gene


No data available for Pathways by source and SIGNOR curated interactions for ABHD14A Gene

Drugs & Compounds for ABHD14A Gene

No Compound Related Data Available

Transcripts for ABHD14A Gene

Unigene Clusters for ABHD14A Gene

Abhydrolase domain containing 14A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD14A Gene

No ASD Table

Relevant External Links for ABHD14A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ABHD14A Gene

mRNA expression in normal human tissues for ABHD14A Gene

Protein differential expression in normal tissues from HIPED for ABHD14A Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ABHD14A Gene

SOURCE GeneReport for Unigene cluster for ABHD14A Gene Hs.534400

genes like me logo Genes that share expression patterns with ABHD14A: view

Protein tissue co-expression partners for ABHD14A Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ABHD14A Gene

Orthologs for ABHD14A Gene

This gene was present in the common ancestor of animals.

Orthologs for ABHD14A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ABHD14A 35
  • 88.93 (n)
  • 87.97 (a)
(Canis familiaris)
Mammalia ABHD14A 35
  • 91.02 (n)
  • 90.41 (a)
ABHD14A 36
  • 69 (a)
(Mus musculus)
Mammalia Abhd14a 35
  • 83.4 (n)
  • 81.38 (a)
Abhd14a 16
Abhd14a 36
  • 75 (a)
(Rattus norvegicus)
Mammalia Abhd14a 35
  • 84.16 (n)
  • 82.64 (a)
(Monodelphis domestica)
Mammalia ABHD14A 36
  • 64 (a)
(Gallus gallus)
Aves ABHD14A 36
  • 51 (a)
(Anolis carolinensis)
Reptilia ABHD14A 36
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd14a 35
  • 57.32 (n)
  • 47.66 (a)
(Danio rerio)
Actinopterygii abhd14a 35
  • 61.35 (n)
  • 55.4 (a)
abhd14a 36
  • 46 (a)
(Caenorhabditis elegans)
Secernentea Y55F3AM.10 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
CSA.1288 36
  • 31 (a)
Species with no ortholog for ABHD14A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABHD14A Gene

Gene Tree for ABHD14A (if available)
Gene Tree for ABHD14A (if available)

Paralogs for ABHD14A Gene

Paralogs for ABHD14A Gene

(2) SIMAP similar genes for ABHD14A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ABHD14A: view

Variants for ABHD14A Gene

Sequence variations from dbSNP and Humsavar for ABHD14A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_031390 -
VAR_031391 -

Structural Variations from Database of Genomic Variants (DGV) for ABHD14A Gene

Variant ID Type Subtype PubMed ID
nsv520211 CNV Gain 19592680
nsv508922 CNV Insertion 20534489
nsv876780 CNV Loss 21882294
dgv5134n71 CNV Loss 21882294
dgv5135n71 CNV Loss 21882294
nsv519445 CNV Gain+Loss 19592680

Variation tolerance for ABHD14A Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.84; 67.20% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ABHD14A Gene

Disorders for ABHD14A Gene

Relevant External Links for ABHD14A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ABHD14A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABHD14A Gene

Publications for ABHD14A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. A high-throughput approach for measuring temporal changes in the interactome. (PMID: 22863883) Kristensen A.R. … Foster L.J. (Nat. Methods 2012) 3

Products for ABHD14A Gene

Sources for ABHD14A Gene