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Aliases for ABHD13 Gene

Aliases for ABHD13 Gene

  • Abhydrolase Domain Containing 13 2 3 5
  • Alpha/Beta Hydrolase Domain-Containing Protein 13 3 4
  • Abhydrolase Domain-Containing Protein 13 3 4
  • C13orf6 3 4
  • Chromosome 13 Open Reading Frame 6 2
  • Protein ABHD13 3
  • BA153I24.2 3
  • EC 3.-.-.- 4
  • BEM46L1 3

External Ids for ABHD13 Gene

Previous HGNC Symbols for ABHD13 Gene

  • C13orf6

Previous GeneCards Identifiers for ABHD13 Gene

  • GC13P107670
  • GC13P108870
  • GC13P089461

Summaries for ABHD13 Gene

GeneCards Summary for ABHD13 Gene

ABHD13 (Abhydrolase Domain Containing 13) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is ABHD17C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD13 Gene

Genomics for ABHD13 Gene

Regulatory Elements for ABHD13 Gene

Enhancers for ABHD13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F108265 1.2 FANTOM5 Ensembl ENCODE 23.7 +48.5 48522 2.2 PKNOX1 CEBPG CTBP1 GATA3 ZNF366 RCOR1 FOS ZNF687 CEBPB ZHX2 ABHD13 TNFSF13B LIG4 ENSG00000277246
GH13F108325 1.2 FANTOM5 Ensembl 20.5 +107.9 107922 1.4 SRF ELK1 FOXA3 CEBPA GABPB1 ABHD13 LIG4 TNFSF13B LOC105370355 RNA5SP39
GH13F108216 0.2 ENCODE 11.8 +0.1 79 3.7 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF143 ZNF207 ABHD13 LIG4 LOC105370354
GH13F108268 0.9 ENCODE 11.8 +51.5 51464 2.9 CTCF LEF1 TAL1 BMI1 RELA NCOR1 POLR2A CBX5 STAT2 EED LIG4 ABHD13 ENSG00000277246 RNA5SP39
GH13F109130 1.3 Ensembl ENCODE 11 +913.1 913122 1.8 CTCF PKNOX1 MAX SIN3A EBF1 RAD21 POLR2A SMC3 CHD2 ZNF202 ABHD13 LOC105370356 MYO16-AS2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ABHD13 on UCSC Golden Path with GeneCards custom track

Promoters for ABHD13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000056957 421 2801 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF143 ZNF207

Genomic Location for ABHD13 Gene

Chromosome:
13
Start:
108,218,379 bp from pter
End:
108,234,255 bp from pter
Size:
15,877 bases
Orientation:
Plus strand

Genomic View for ABHD13 Gene

Genes around ABHD13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABHD13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABHD13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD13 Gene

Proteins for ABHD13 Gene

  • Protein details for ABHD13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L211-ABHDD_HUMAN
    Recommended name:
    Protein ABHD13
    Protein Accession:
    Q7L211
    Secondary Accessions:
    • B3KWE7
    • Q8NBW1
    • Q96JX9

    Protein attributes for ABHD13 Gene

    Size:
    337 amino acids
    Molecular mass:
    38548 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH70226.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AK075195; Type=Erroneous termination; Positions=167; Note=Translated as Leu.; Evidence={ECO:0000305}; Sequence=BAB55387.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ABHD13 Gene

Post-translational modifications for ABHD13 Gene

  • Glycosylation at Asn 299
  • Modification sites at PhosphoSitePlus

Other Protein References for ABHD13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ABHD13 Gene

Domains & Families for ABHD13 Gene

Gene Families for ABHD13 Gene

Protein Domains for ABHD13 Gene

Suggested Antigen Peptide Sequences for ABHD13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L211

UniProtKB/Swiss-Prot:

ABHDD_HUMAN :
  • Belongs to the serine esterase family.
Family:
  • Belongs to the serine esterase family.
genes like me logo Genes that share domains with ABHD13: view

Function for ABHD13 Gene

Enzyme Numbers (IUBMB) for ABHD13 Gene

Gene Ontology (GO) - Molecular Function for ABHD13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ABHD13: view
genes like me logo Genes that share phenotypes with ABHD13: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ABHD13

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABHD13 Gene

Localization for ABHD13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABHD13 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABHD13 Gene COMPARTMENTS Subcellular localization image for ABHD13 gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 1
extracellular 1
lysosome 1
nucleus 1
peroxisome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ABHD13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ABHD13: view

Pathways & Interactions for ABHD13 Gene

SuperPathways for ABHD13 Gene

No Data Available

Interacting Proteins for ABHD13 Gene

Selected Interacting proteins: Q7L211-ABHDD_HUMAN for ABHD13 Gene via IID

Gene Ontology (GO) - Biological Process for ABHD13 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ABHD13 Gene

Transcripts for ABHD13 Gene

mRNA/cDNA for ABHD13 Gene

Unigene Clusters for ABHD13 Gene

Abhydrolase domain containing 13:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD13 Gene

No ASD Table

Relevant External Links for ABHD13 Gene

GeneLoc Exon Structure for
ABHD13
ECgene alternative splicing isoforms for
ABHD13

Expression for ABHD13 Gene

mRNA expression in normal human tissues for ABHD13 Gene

Protein differential expression in normal tissues from HIPED for ABHD13 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (49.4), Placenta (10.7), and Islet of Langerhans (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABHD13 Gene



Protein tissue co-expression partners for ABHD13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ABHD13 Gene:

ABHD13

SOURCE GeneReport for Unigene cluster for ABHD13 Gene:

Hs.183528
genes like me logo Genes that share expression patterns with ABHD13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ABHD13 Gene

Orthologs for ABHD13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABHD13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABHD13 34 35
  • 99.8 (n)
oppossum
(Monodelphis domestica)
Mammalia ABHD13 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABHD13 34 35
  • 94.86 (n)
cow
(Bos Taurus)
Mammalia ABHD13 34 35
  • 91.2 (n)
mouse
(Mus musculus)
Mammalia Abhd13 34 16 35
  • 86.15 (n)
rat
(Rattus norvegicus)
Mammalia Abhd13 34
  • 85.95 (n)
chicken
(Gallus gallus)
Aves ABHD13 34 35
  • 86.25 (n)
lizard
(Anolis carolinensis)
Reptilia ABHD13 35
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd13 34
  • 77.88 (n)
Str.12504 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.12577 34
zebrafish
(Danio rerio)
Actinopterygii abhd13 34 35
  • 68.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta Bem46 34 35
  • 49.4 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008746 34
  • 48.21 (n)
worm
(Caenorhabditis elegans)
Secernentea F01D5.8 35
  • 17 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNL320W 34
  • 47.69 (n)
-- 35
  • 37 (a)
OneToMany
-- 37
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20989g 34
  • 47.66 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL187W 34
  • 43.14 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons WAV2 34
  • 48.16 (n)
rice
(Oryza sativa)
Liliopsida Os07g0608300 34
  • 48.01 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes bem46 34
  • 51.56 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03276 34
  • 47.09 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2268 35
  • 42 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8795 34
Species where no ortholog for ABHD13 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABHD13 Gene

ENSEMBL:
Gene Tree for ABHD13 (if available)
TreeFam:
Gene Tree for ABHD13 (if available)

Paralogs for ABHD13 Gene

Paralogs for ABHD13 Gene

genes like me logo Genes that share paralogs with ABHD13: view

Variants for ABHD13 Gene

Sequence variations from dbSNP and Humsavar for ABHD13 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1055859 -- 108,230,111(+) GACTC(A/C)CAATG reference, missense
rs11069723 -- 108,226,133(+) AGTGG(A/T)CCGTA intron-variant
rs11069724 -- 108,227,092(+) CAACT(C/G)ATTGT intron-variant
rs111305781 -- 108,218,819(+) GGGGT(C/T)GTGCG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs111306760 -- 108,217,107(+) GGGCC(A/G)GTGGC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Variation tolerance for ABHD13 Gene

Residual Variation Intolerance Score: 63.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABHD13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABHD13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ABHD13 Gene

Disorders for ABHD13 Gene

Relevant External Links for ABHD13

Genetic Association Database (GAD)
ABHD13
Human Genome Epidemiology (HuGE) Navigator
ABHD13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABHD13

No disorders were found for ABHD13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABHD13 Gene

Publications for ABHD13 Gene

  1. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 46 64
  2. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney R.J. … Gill M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 46 64
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4 64

Products for ABHD13 Gene

Sources for ABHD13 Gene

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