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Aliases for ABHD13 Gene

Aliases for ABHD13 Gene

  • Abhydrolase Domain Containing 13 2 3 5
  • Alpha/Beta Hydrolase Domain-Containing Protein 13 3 4
  • Abhydrolase Domain-Containing Protein 13 3 4
  • C13orf6 3 4
  • Chromosome 13 Open Reading Frame 6 2
  • Protein ABHD13 3
  • BA153I24.2 3
  • EC 3.-.-.- 4
  • BEM46L1 3

External Ids for ABHD13 Gene

Previous HGNC Symbols for ABHD13 Gene

  • C13orf6

Previous GeneCards Identifiers for ABHD13 Gene

  • GC13P107670
  • GC13P108870
  • GC13P089461

Summaries for ABHD13 Gene

GeneCards Summary for ABHD13 Gene

ABHD13 (Abhydrolase Domain Containing 13) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is ABHD17C.

Additional gene information for ABHD13 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD13 Gene

Genomics for ABHD13 Gene

Regulatory Elements for ABHD13 Gene

Enhancers for ABHD13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H108266 1.4 FANTOM5 Ensembl ENCODE dbSUPER 23.7 +48.5 48522 1 POLR2A MLLT1 ETV6 SPI1 GABPA ABHD13 TNFSF13B LIG4 ENSG00000277246
GH13H108326 0.9 FANTOM5 Ensembl 20.4 +108.1 108121 0 SRF FOXA2 FOXA3 CEBPA ELF1 ABHD13 LIG4 TNFSF13B LOC105370355 RNA5SP39
GH13H108216 1.4 ENCODE dbSUPER 11.7 +0.1 79 3 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 DEK ABHD13 LIG4 GC13P108246
GH13H108268 1.1 ENCODE dbSUPER 11.8 +51.5 51464 2 TBL1XR1 SIN3A BMI1 BATF RAD21 ZNF143 ZNF207 RCOR1 RUNX3 CREM ABHD13 LIG4 ENSG00000277246 RNA5SP39
GH13H108211 1.4 Ensembl ENCODE dbSUPER 7.3 -4.4 -4385 4 ELF3 RB1 ARID4B SIN3A ZBTB40 ETS1 GLIS2 EGR1 ELK1 CREM LIG4 ABHD13 GC13P108126
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ABHD13 on UCSC Golden Path with GeneCards custom track

Promoters for ABHD13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000273230 221 2001 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 DEK

Genomic Location for ABHD13 Gene

Chromosome:
13
Start:
108,218,379 bp from pter
End:
108,234,255 bp from pter
Size:
15,877 bases
Orientation:
Plus strand

Genomic View for ABHD13 Gene

Genes around ABHD13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABHD13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABHD13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD13 Gene

Proteins for ABHD13 Gene

  • Protein details for ABHD13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L211-ABHDD_HUMAN
    Recommended name:
    Protein ABHD13
    Protein Accession:
    Q7L211
    Secondary Accessions:
    • B3KWE7
    • Q8NBW1
    • Q96JX9

    Protein attributes for ABHD13 Gene

    Size:
    337 amino acids
    Molecular mass:
    38548 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH70226.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AK075195; Type=Erroneous termination; Positions=167; Note=Translated as Leu.; Evidence={ECO:0000305}; Sequence=BAB55387.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ABHD13 Gene

Post-translational modifications for ABHD13 Gene

  • Glycosylation at Asn299
  • Modification sites at PhosphoSitePlus

Other Protein References for ABHD13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ABHD13 Gene

Domains & Families for ABHD13 Gene

Gene Families for ABHD13 Gene

Protein Domains for ABHD13 Gene

Suggested Antigen Peptide Sequences for ABHD13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L211

UniProtKB/Swiss-Prot:

ABHDD_HUMAN :
  • Belongs to the serine esterase family.
Family:
  • Belongs to the serine esterase family.
genes like me logo Genes that share domains with ABHD13: view

Function for ABHD13 Gene

Enzyme Numbers (IUBMB) for ABHD13 Gene

Gene Ontology (GO) - Molecular Function for ABHD13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ABHD13: view
genes like me logo Genes that share phenotypes with ABHD13: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ABHD13

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ABHD13
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABHD13 Gene

Localization for ABHD13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABHD13 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABHD13 gene
Compartment Confidence
cytosol 3
plasma membrane 1
extracellular 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ABHD13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ABHD13: view

Pathways & Interactions for ABHD13 Gene

SuperPathways for ABHD13 Gene

No Data Available

Interacting Proteins for ABHD13 Gene

Gene Ontology (GO) - Biological Process for ABHD13 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ABHD13 Gene

Drugs & Compounds for ABHD13 Gene

No Compound Related Data Available

Transcripts for ABHD13 Gene

mRNA/cDNA for ABHD13 Gene

Unigene Clusters for ABHD13 Gene

Abhydrolase domain containing 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ABHD13
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD13 Gene

No ASD Table

Relevant External Links for ABHD13 Gene

GeneLoc Exon Structure for
ABHD13
ECgene alternative splicing isoforms for
ABHD13

Expression for ABHD13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ABHD13 Gene

Protein differential expression in normal tissues from HIPED for ABHD13 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (49.4), Placenta (10.7), and Islet of Langerhans (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABHD13 Gene



Protein tissue co-expression partners for ABHD13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ABHD13 Gene:

ABHD13

SOURCE GeneReport for Unigene cluster for ABHD13 Gene:

Hs.183528

Evidence on tissue expression from TISSUES for ABHD13 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ABHD13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABHD13 Gene

Orthologs for ABHD13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABHD13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABHD13 33 34
  • 99.8 (n)
oppossum
(Monodelphis domestica)
Mammalia ABHD13 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABHD13 33 34
  • 94.86 (n)
cow
(Bos Taurus)
Mammalia ABHD13 33 34
  • 91.2 (n)
mouse
(Mus musculus)
Mammalia Abhd13 33 16 34
  • 86.15 (n)
rat
(Rattus norvegicus)
Mammalia Abhd13 33
  • 85.95 (n)
chicken
(Gallus gallus)
Aves ABHD13 33 34
  • 86.25 (n)
lizard
(Anolis carolinensis)
Reptilia ABHD13 34
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd13 33
  • 77.88 (n)
Str.12504 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.12577 33
zebrafish
(Danio rerio)
Actinopterygii abhd13 33 34
  • 68.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta Bem46 33 34
  • 49.4 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008746 33
  • 48.21 (n)
worm
(Caenorhabditis elegans)
Secernentea F01D5.8 34
  • 17 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNL320W 33
  • 47.69 (n)
-- 34
  • 37 (a)
OneToMany
-- 36
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20989g 33
  • 47.66 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL187W 33
  • 43.14 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons WAV2 33
  • 48.16 (n)
rice
(Oryza sativa)
Liliopsida Os07g0608300 33
  • 48.01 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes bem46 33
  • 51.56 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03276 33
  • 47.09 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2268 34
  • 42 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8795 33
Species where no ortholog for ABHD13 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABHD13 Gene

ENSEMBL:
Gene Tree for ABHD13 (if available)
TreeFam:
Gene Tree for ABHD13 (if available)

Paralogs for ABHD13 Gene

Paralogs for ABHD13 Gene

genes like me logo Genes that share paralogs with ABHD13: view

Variants for ABHD13 Gene

Sequence variations from dbSNP and Humsavar for ABHD13 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000221840 -- 108,235,265(+) CTAAA(C/T)CGAGG utr-variant-3-prime
rs1000260042 -- 108,223,305(+) TAAGT(C/G)TGAAC intron-variant
rs1000345896 -- 108,229,106(+) CAATT(A/G)CATGT intron-variant
rs1000504303 -- 108,225,623(+) GTTAA(C/G)GAGTT intron-variant
rs1000618045 -- 108,220,061(+) TTTAT(C/T)TCAAC intron-variant, upstream-variant-2KB

Variation tolerance for ABHD13 Gene

Residual Variation Intolerance Score: 63.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABHD13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABHD13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ABHD13 Gene

Disorders for ABHD13 Gene

Relevant External Links for ABHD13

Genetic Association Database (GAD)
ABHD13
Human Genome Epidemiology (HuGE) Navigator
ABHD13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABHD13

No disorders were found for ABHD13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABHD13 Gene

Publications for ABHD13 Gene

  1. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 45 60
  2. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney RJ … Gill M (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 45 60
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 60

Products for ABHD13 Gene

Sources for ABHD13 Gene

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