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Aliases for ABHD12B Gene

Aliases for ABHD12B Gene

  • Abhydrolase Domain Containing 12B 2 3
  • C14orf29 3 4
  • Abhydrolase Domain-Containing Protein 12B 3
  • Chromosome 14 Open Reading Frame 29 2
  • EC 3.-.-.- 4
  • C14_5314 3
  • BEM46L3 3

External Ids for ABHD12B Gene

Previous HGNC Symbols for ABHD12B Gene

  • C14orf29

Previous GeneCards Identifiers for ABHD12B Gene

  • GC14P050409
  • GC14P051338
  • GC14P031464

Summaries for ABHD12B Gene

GeneCards Summary for ABHD12B Gene

ABHD12B (Abhydrolase Domain Containing 12B) is a Protein Coding gene. GO annotations related to this gene include acylglycerol lipase activity. An important paralog of this gene is ABHD12.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD12B Gene

Genomics for ABHD12B Gene

Regulatory Elements for ABHD12B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ABHD12B Gene

50,872,160 bp from pter
50,904,970 bp from pter
32,811 bases
Plus strand

Genomic View for ABHD12B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABHD12B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD12B Gene

Proteins for ABHD12B Gene

  • Protein details for ABHD12B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Abhydrolase domain-containing protein 12B
    Protein Accession:
    Secondary Accessions:
    • Q3KNR9
    • Q3KNS0
    • Q7Z5M6
    • Q7Z5M7
    • Q8N4D2

    Protein attributes for ABHD12B Gene

    362 amino acids
    Molecular mass:
    40776 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH34603.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAP78477.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAP78479.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for ABHD12B Gene


neXtProt entry for ABHD12B Gene

Proteomics data for ABHD12B Gene at MOPED

Post-translational modifications for ABHD12B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ABHD12B Gene

No data available for DME Specific Peptides for ABHD12B Gene

Domains for ABHD12B Gene

Gene Families for ABHD12B Gene

Protein Domains for ABHD12B Gene


Suggested Antigen Peptide Sequences for ABHD12B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the serine esterase family.
  • Belongs to the serine esterase family.
genes like me logo Genes that share domains with ABHD12B: view

Function for ABHD12B Gene

Enzyme Numbers (IUBMB) for ABHD12B Gene

Gene Ontology (GO) - Molecular Function for ABHD12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008236 serine-type peptidase activity --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ABHD12B: view

Phenotypes for ABHD12B Gene

GenomeRNAi human phenotypes for ABHD12B:
genes like me logo Genes that share phenotypes with ABHD12B: view

Animal Model Products

CRISPR Products

miRNA for ABHD12B Gene

miRTarBase miRNAs that target ABHD12B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABHD12B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Animal Models , Transcription Factor Targets and HOMER Transcription for ABHD12B Gene

Localization for ABHD12B Gene

Subcellular locations from

Jensen Localization Image for ABHD12B Gene COMPARTMENTS Subcellular localization image for ABHD12B gene
Compartment Confidence
cytosol 2
extracellular 2
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ABHD12B Gene

Pathways for ABHD12B Gene

SuperPathways for ABHD12B Gene

No Data Available

Interacting Proteins for ABHD12B Gene

Gene Ontology (GO) - Biological Process for ABHD12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with ABHD12B: view

No data available for Pathways by source for ABHD12B Gene

Transcripts for ABHD12B Gene

Unigene Clusters for ABHD12B Gene

Abhydrolase domain containing 12B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABHD12B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD12B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP2: -
SP3: - -
SP4: - - -

Relevant External Links for ABHD12B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ABHD12B Gene

mRNA expression in normal human tissues for ABHD12B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABHD12B Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (9.2), Skin - Not Sun Exposed (Suprapubic) (8.3), Brain - Putamen (basal ganglia) (5.9), and Brain - Caudate (basal ganglia) (4.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ABHD12B Gene

SOURCE GeneReport for Unigene cluster for ABHD12B Gene Hs.271896

genes like me logo Genes that share expressions with ABHD12B: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for ABHD12B Gene

Orthologs for ABHD12B Gene

This gene was present in the common ancestor of animals.

Orthologs for ABHD12B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ABHD12B 35
  • 86.8 (n)
  • 84.1 (a)
ABHD12B 36
  • 84 (a)
(Canis familiaris)
Mammalia ABHD12B 35
  • 86.78 (n)
  • 85.42 (a)
ABHD12B 36
  • 88 (a)
(Mus musculus)
Mammalia Abhd12b 35
  • 79.85 (n)
  • 75.77 (a)
Abhd12b 16
Abhd12b 36
  • 74 (a)
(Pan troglodytes)
Mammalia ABHD12B 35
  • 99.45 (n)
  • 99.45 (a)
ABHD12B 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia ABHD12B 36
  • 73 (a)
(Gallus gallus)
Aves ABHD12B 35
  • 56.57 (n)
  • 48.48 (a)
ABHD12B 36
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495642 35
  • 62.6 (n)
  • 52.88 (a)
Str.8535 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.19972 35
(Danio rerio)
Actinopterygii si:ch211-117n7.6 35
  • 55.07 (n)
  • 46.74 (a)
ABHD12B (1 of 2) 36
  • 37 (a)
ABHD12B (2 of 2) 36
  • 38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15111 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea Y97E10AL.2 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
Species with no ortholog for ABHD12B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABHD12B Gene

Gene Tree for ABHD12B (if available)
Gene Tree for ABHD12B (if available)

Paralogs for ABHD12B Gene

Paralogs for ABHD12B Gene

(1) SIMAP similar genes for ABHD12B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ABHD12B: view

Variants for ABHD12B Gene

Sequence variations from dbSNP and Humsavar for ABHD12B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1547763 -- 50,875,758(-) AGAAC(A/C)GAGTG intron-variant
rs1556931 -- 50,870,751(-) GCGCG(C/T)GCGCA upstream-variant-2KB
rs1660909 -- 50,895,618(-) GATCT(C/G/T)GGACG intron-variant
rs1953878 -- 50,875,513(-) ACAGC(A/G)TCCCA intron-variant
rs1953879 -- 50,871,519(-) ACACC(C/T)TGAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ABHD12B Gene

Variant ID Type Subtype PubMed ID
nsv832794 CNV Gain 17160897
nsv901938 CNV Loss 21882294

Relevant External Links for ABHD12B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABHD12B Gene

Disorders for ABHD12B Gene

Relevant External Links for ABHD12B

Genetic Association Database (GAD)

No disorders were found for ABHD12B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ABHD12B Gene

Publications for ABHD12B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PMID: 17903300) Fox C.S. … Atwood L.D. (BMC Med. Genet. 2007) 48
  5. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PMID: 17903306) Newton-Cheh C. … Larson M.G. (BMC Med. Genet. 2007) 48

Products for ABHD12B Gene

Sources for ABHD12B Gene

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