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Aliases for ABHD10 Gene

Aliases for ABHD10 Gene

  • Abhydrolase Domain Containing 10 2 3 5
  • Alpha/Beta Hydrolase Domain-Containing Protein 10 4
  • Abhydrolase Domain-Containing Protein 10 4
  • EC 3.1.1.93 4

External Ids for ABHD10 Gene

Previous GeneCards Identifiers for ABHD10 Gene

  • GC03P113181
  • GC03P111697
  • GC03P109073

Summaries for ABHD10 Gene

Entrez Gene Summary for ABHD10 Gene

  • This gene encodes a mitochondrially-localized enzyme that acts in liver cells as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

GeneCards Summary for ABHD10 Gene

ABHD10 (Abhydrolase Domain Containing 10) is a Protein Coding gene. Among its related pathways are Phase II conjugation and Porphyrin and chlorophyll metabolism. GO annotations related to this gene include serine-type peptidase activity and hydrolase activity, hydrolyzing O-glycosyl compounds.

UniProtKB/Swiss-Prot for ABHD10 Gene

  • Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD10 Gene

Genomics for ABHD10 Gene

Regulatory Elements for ABHD10 Gene

Enhancers for ABHD10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ABHD10 on UCSC Golden Path with GeneCards custom track

Promoters for ABHD10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ABHD10 on UCSC Golden Path with GeneCards custom track

Genomic Location for ABHD10 Gene

Chromosome:
3
Start:
111,978,876 bp from pter
End:
111,993,368 bp from pter
Size:
14,493 bases
Orientation:
Plus strand

Genomic View for ABHD10 Gene

Genes around ABHD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABHD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABHD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD10 Gene

Proteins for ABHD10 Gene

  • Protein details for ABHD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUJ1-ABHDA_HUMAN
    Recommended name:
    Mycophenolic acid acyl-glucuronide esterase, mitochondrial
    Protein Accession:
    Q9NUJ1
    Secondary Accessions:
    • B7Z6A8
    • C9IZX5
    • D3DN63
    • Q8TCF9

    Protein attributes for ABHD10 Gene

    Size:
    306 amino acids
    Molecular mass:
    33933 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABHD10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABHD10 Gene

Proteomics data for ABHD10 Gene at MOPED

Post-translational modifications for ABHD10 Gene

  • Ubiquitination at Lys 200
  • Modification sites at PhosphoSitePlus

Other Protein References for ABHD10 Gene

Antibody Products

No data available for DME Specific Peptides for ABHD10 Gene

Domains & Families for ABHD10 Gene

Gene Families for ABHD10 Gene

Protein Domains for ABHD10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NUJ1

UniProtKB/Swiss-Prot:

ABHDA_HUMAN :
  • Belongs to the AB hydrolase superfamily.
Family:
  • Belongs to the AB hydrolase superfamily.
genes like me logo Genes that share domains with ABHD10: view

Function for ABHD10 Gene

Molecular function for ABHD10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Mycophenolic acid O-acyl-glucuronide + H(2)O = mycophenolate + D-glucuronate.
UniProtKB/Swiss-Prot Function:
Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate.

Enzyme Numbers (IUBMB) for ABHD10 Gene

genes like me logo Genes that share phenotypes with ABHD10: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ABHD10

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABHD10 Gene

Localization for ABHD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABHD10 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABHD10 Gene COMPARTMENTS Subcellular localization image for ABHD10 gene
Compartment Confidence
cytosol 5
mitochondrion 5
nucleus 2
peroxisome 2
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for ABHD10 Gene

Pathways & Interactions for ABHD10 Gene

genes like me logo Genes that share pathways with ABHD10: view

Pathways by source for ABHD10 Gene

Gene Ontology (GO) - Biological Process for ABHD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0052695 cellular glucuronidation TAS --
genes like me logo Genes that share ontologies with ABHD10: view

No data available for SIGNOR curated interactions for ABHD10 Gene

Drugs & Compounds for ABHD10 Gene

(2) Drugs for ABHD10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mycophenolic acid Approved Pharma 906
D-Glucuronic acid Experimental Pharma 0

(2) Additional Compounds for ABHD10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Mycophenolic acid O-acyl-glucuronide
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with ABHD10: view

Transcripts for ABHD10 Gene

Unigene Clusters for ABHD10 Gene

Abhydrolase domain containing 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD10 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: -
SP2: - -
SP3:

Relevant External Links for ABHD10 Gene

GeneLoc Exon Structure for
ABHD10
ECgene alternative splicing isoforms for
ABHD10

Expression for ABHD10 Gene

mRNA expression in normal human tissues for ABHD10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ABHD10 Gene

This gene is overexpressed in Salivary gland (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ABHD10 Gene



SOURCE GeneReport for Unigene cluster for ABHD10 Gene Hs.477115

genes like me logo Genes that share expression patterns with ABHD10: view

Protein tissue co-expression partners for ABHD10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ABHD10 Gene

Orthologs for ABHD10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ABHD10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ABHD10 35
  • 86.6 (n)
  • 84.64 (a)
ABHD10 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABHD10 35
  • 85.46 (n)
  • 83.61 (a)
ABHD10 36
  • 48 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abhd10 35
  • 81.67 (n)
  • 77.66 (a)
Abhd10 16
Abhd10 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ABHD10 35
  • 99.89 (n)
  • 100 (a)
ABHD10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abhd10 35
  • 80.94 (n)
  • 77.4 (a)
oppossum
(Monodelphis domestica)
Mammalia ABHD10 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABHD10 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves ABHD10 35
  • 67.73 (n)
  • 67.97 (a)
ABHD10 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABHD10 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd10 35
  • 68.21 (n)
  • 65.25 (a)
Str.11875 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.14582 35
zebrafish
(Danio rerio)
Actinopterygii abhd10a 35
  • 62.21 (n)
  • 64.5 (a)
wufb10b08 35
abhd10a 36
  • 45 (a)
OneToMany
abhd10b 36
  • 59 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4816 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToOne
Species with no ortholog for ABHD10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABHD10 Gene

ENSEMBL:
Gene Tree for ABHD10 (if available)
TreeFam:
Gene Tree for ABHD10 (if available)

Paralogs for ABHD10 Gene

Pseudogenes.org Pseudogenes for ABHD10 Gene

genes like me logo Genes that share paralogs with ABHD10: view

No data available for Paralogs for ABHD10 Gene

Variants for ABHD10 Gene

Sequence variations from dbSNP and Humsavar for ABHD10 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs17429033 - 111,991,551(+) ATGAC(A/G)TTGTA nc-transcript-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
rs712524 -- 111,977,058(-) tccca(A/C)agtgc upstream-variant-2KB
rs712525 -- 111,980,977(-) TTGGT(C/G)TGCCC intron-variant
rs774745 -- 111,983,023(-) CACTC(A/G)GTATA intron-variant
rs774748 -- 111,993,700(-) ATCTC(A/G)AATCA downstream-variant-500B

Variation tolerance for ABHD10 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABHD10 Gene

HapMap Linkage Disequilibrium report
ABHD10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ABHD10 Gene

Disorders for ABHD10 Gene

Relevant External Links for ABHD10

Genetic Association Database (GAD)
ABHD10
Human Genome Epidemiology (HuGE) Navigator
ABHD10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABHD10

No disorders were found for ABHD10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABHD10 Gene

Publications for ABHD10 Gene

  1. Human alpha/beta hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl- glucuronide in liver. (PMID: 22294686) Iwamura A. … Yokoi T. (J. Biol. Chem. 2012) 2 3 4 67
  2. KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation. (PMID: 25582440) Hong J.H. … Raught B. (Mol. Cell Proteomics 2015) 3
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for ABHD10 Gene

Sources for ABHD10 Gene

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