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ABHD10 Gene

protein-coding   GIFtS: 50
GCID: GC03P111697

Abhydrolase Domain Containing 10

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Abhydrolase Domain Containing 101 2     EC 3.1.1.933
Abhydrolase Domain-Containing Protein 10, Mitochondrial2     Abhydrolase Domain-Containing Protein 103
Alpha/Beta Hydrolase Domain-Containing Protein 10, Mitochondrial2     Alpha/Beta Hydrolase Domain-Containing Protein 103
Mycophenolic Acid Acyl-Glucuronide Esterase, Mitochondrial2     

External Ids:    HGNC: 256561   Entrez Gene: 553472   Ensembl: ENSG000001448277   UniProtKB: Q9NUJ13   

Export aliases for ABHD10 gene to outside databases

Previous GC identifers: GC03P113181 GC03P109073


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ABHD10 Gene:
This gene encodes a mitochondrially-localized enzyme that acts in liver cells as a hydrolase. The encoded protein
removes glucuronide from mycophenolic acid acyl-glucuronide. There is a pseudogene for this gene on chromosome 6.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jan 2013)

GeneCards Summary for ABHD10 Gene:
ABHD10 (abhydrolase domain containing 10) is a protein-coding gene. Diseases associated with ABHD10 include hepatocellular carcinoma. GO annotations related to this gene include hydrolase activity, hydrolyzing O-glycosyl compounds.

UniProtKB/Swiss-Prot: ABHDA_HUMAN, Q9NUJ1
Function: Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the
immunosuppressant drug mycophenolate




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ABHD10 gene promoter:
         GR   C/EBPbeta   USF1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   USF-1   IRF-7A   GR-alpha   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidABHD10 promoter sequence
   Search Chromatin IP Primers for ABHD10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ABHD10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.2   Ensembl cytogenetic band:  3q13.2   HGNC cytogenetic band: 3q13.2

ABHD10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABHD10 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P111697:  view genomic region     (about GC identifiers)

Start:
111,697,828 bp from pter      End:
111,712,210 bp from pter
Size:
14,383 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ABHDA_HUMAN, Q9NUJ1 (See protein sequence)
Recommended Name: Mycophenolic acid acyl-glucuronide esterase, mitochondrial precursor  
Size: 306 amino acids; 33933 Da
Secondary accessions: D3DN63 Q8TCF9

Explore the universe of human proteins at neXtProt for ABHD10: NX_Q9NUJ1

Explore proteomics data for ABHD10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys200
  • Modification sites at PhosphoSitePlus

  • See ABHD10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001258998.1  NP_060864.1  

    ENSEMBL proteins: 
     ENSP00000418162   ENSP00000273359   ENSP00000417880   ENSP00000418973   ENSP00000442932  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ABHD: Abhydrolase domain containing

    ProtoNet protein and cluster: Q9NUJ1

    1 Blocks protein domain: IPB003089 Alpha/beta hydrolase fold signature

    UniProtKB/Swiss-Prot: ABHDA_HUMAN, Q9NUJ1
    Similarity: Belongs to the AB hydrolase superfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ABHDA_HUMAN, Q9NUJ1
    Function: Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the
    immunosuppressant drug mycophenolate
    Catalytic activity: Mycophenolic acid O-acyl-glucuronide + H(2)O = mycophenolate + D-glucuronate

         Enzyme Number (IUBMB): EC 3.1.1.931

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004553hydrolase activity, hydrolyzing O-glycosyl compounds IDA--
    GO:0008236serine-type peptidase activity ----
    GO:0016787hydrolase activity ----
         
    ABHD10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ABHD10:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ABHD10
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    miRNA
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    miRTarBase miRNAs that target ABHD10:
    hsa-mir-16-5p (MIRT001482)

    Block miRNA regulation of human, mouse, rat ABHD10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ABHD10 (see all 20):
    hsa-miR-607 hsa-miR-520d-5p hsa-miR-548m hsa-miR-2115 hsa-miR-29a* hsa-miR-3148 hsa-miR-2113 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidABHD10 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ABHD10

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ABHDA_HUMAN, Q9NUJ1: Mitochondrion (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion4
    peroxisome2
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005829cytosol IDA--

    ABHD10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ABHD10
    Interactions:

        Search GeneGlobe Interaction Network for ABHD10

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for ABHD10 (Q9NUJ13 ENSP000002733594) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    H2AFXP161043, ENSP000003643104I2D: score=2 STRING: ENSP00000364310
    SQSTM1Q135013I2D: score=3 
    UBCENSP000003448184STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0019391glucuronoside catabolic process IDA--

    ABHD10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ABHD10 (ABHDA)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ABHD10 gene (2 alternative transcripts): 
    NM_001272069.1  NM_018394.3  

    Unigene Cluster for ABHD10:

    Abhydrolase domain containing 10
    Hs.477115  [show with all ESTs]
    Unigene Representative Sequence: NM_001272069
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491580 ENST00000497293 ENST00000273359(uc003dyk.4 uc011bhq.2)
    ENST00000493784 ENST00000494817 ENST00000534857
    miRNA
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    Block miRNA regulation of human, mouse, rat ABHD10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ABHD10 (see all 20):
    hsa-miR-607 hsa-miR-520d-5p hsa-miR-548m hsa-miR-2115 hsa-miR-29a* hsa-miR-3148 hsa-miR-2113 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidABHD10 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ABHD10
      QuantiFast Probe-based Assays in human, mouse, rat ABHD10

    Additional mRNA sequence: 

    AK002204.1 AK300018.1 AL713726.1 BC014516.2 NR_073570.1 NR_073571.1 

    8 DOTS entries:

    DT.317371  DT.100779651  DT.95173835  DT.120872177  DT.97845041  DT.100779652  DT.120872180  DT.99927685 

    Selected AceView cDNA sequences (see all 232):

    BC014516 BM761395 AW779685 AA774295 AI521709 BG390295 BX358216 AA113264 
    BQ227578 CA441637 BM831397 BM703932 BQ924203 BI916347 AW242493 AI459337 
    AA552460 AW271801 AI435002 AI261450 BM761387 AW611570 AI126211 BE219556 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ABHD10    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:                    -                                 
    SP2:                    -                 -               
    SP3:                                                      


    ECgene alternative splicing isoforms for ABHD10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ABHD10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ABHD10 Expression
    About this image


    ABHD10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    ABHD10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ABHD10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.477115
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABHD10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ABHD10 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Abhd101 , 5 abhydrolase domain containing 101, 5 81.67(n)1
    77.66(a)1
      16 (30.04 cM)5
    2130121  NM_172511.41  NP_766099.31 
     457297255 
    chicken
    (Gallus gallus)
    Aves ABHD101 abhydrolase domain containing 10 67.73(n)
    67.97(a)
      418419  XM_416633.4  XP_416633.4 
    lizard
    (Anolis carolinensis)
    Reptilia ABHD106
    abhydrolase domain containing 10
    66(a)
    1 ↔ 1
    3(167719536-167722890)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.145822 Xenopus laevis transcribed sequence with weak similarity more 74.88(n)    BQ731168.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb10b082 Transcribed sequence with weak similarity to protein more 73.94(n)    AL922340.1 


    ENSEMBL Gene Tree for ABHD10 (if available)
    TreeFam Gene Tree for ABHD10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ABHD10 gene

    ABHD10 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ABHD10
    PGOHUM00000243735


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ABHD10 (see all 396)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37627071,2
    C,F--111695885(+) GGCTCA/TCACCT 4 -- us2k16Minor allele frequency- T:0.28NA 130
    rs7125241,2
    F--111695905(-) tcccaA/Cagtgc 4 -- us2k11Minor allele frequency- C:0.00NA 2
    rs37627081,2
    C,F--111695911(+) TGGGAG/AGCCAA 4 -- us2k12Minor allele frequency- A:0.50NA 4
    rs580859321,2
    C,F--111695914(+) GAAGCC/AAAGGG 4 -- us2k12Minor allele frequency- A:0.50NA 4
    rs1908060281,2
    --111695920(+) AAGGGG/TGGTGG 4 -- us2k10--------
    rs1840109901,2
    --111696022(+) TCGGTG/TCCTGT 4 -- us2k10--------
    rs1503874561,2
    --111696137(+) AGAGCA/GAGACT 4 -- us2k10--------
    rs1486168691,2
    C--111696155(+) AACAT-/ACACAC
            
    ACACA
    4 -- cds1 us2k10--------
    rs587929371,2
    C--111696160(+) ACACA-/CACAC 
     
    /CACACA
    AAAAC
    6 -- us2k1 cds10--------
    rs284106121,2
    C,F--111696173(+) ACACAA/CAAACC 4 -- us2k15Minor allele frequency- C:0.35WA CSA NA EA 362

    HapMap Linkage Disequilibrium report for ABHD10 (111697828 - 111712210 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ABHD10: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ABHD10
    DNA2.0 Custom Variant and Variant Library Synthesis for ABHD10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for ABHD10:    
    About MalaCards
    hepatocellular carcinoma


    ABHD10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ABHD10
    Human Genome Epidemiology (HuGE) Navigator: ABHD10 (2 documents)

    Export disorders for ABHD10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ABHD10 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with ABHD10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human alpha/beta hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl- glucuronide in liver. (PubMed id 22294686)1, 2, 3 Iwamura A.... Yokoi T. (J. Biol. Chem. 2012)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The emerging role of human esterases. (PubMed id 22813719)1 Fukami T. and Yokoi T. (Drug Metab. Pharmacokinet. 2012)
    7. Competitive activity-based protein profiling identifies aza-I^-lactams as a versatile chemotype for serine hydrolase inhibition. (PubMed id 22400490)1 Zuhl A.M....Cravatt B.F. (J. Am. Chem. Soc. 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55347 HGNC: 25656 AceView: FLJ11342 Ensembl:ENSG00000144827 euGenes: HUgn55347
    ECgene: ABHD10 H-InvDB: ABHD10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ABHD10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ABHD10 gene:
    Search GeneIP for patents involving ABHD10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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