Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ABHD10 Gene

Aliases for ABHD10 Gene

  • Abhydrolase Domain Containing 10 2 3 5
  • Alpha/Beta Hydrolase Domain-Containing Protein 10 4
  • Abhydrolase Domain-Containing Protein 10 4
  • EC 4

External Ids for ABHD10 Gene

Previous GeneCards Identifiers for ABHD10 Gene

  • GC03P113181
  • GC03P111697
  • GC03P109073

Summaries for ABHD10 Gene

Entrez Gene Summary for ABHD10 Gene

  • This gene encodes a mitochondrially-localized enzyme that acts in liver cells as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

GeneCards Summary for ABHD10 Gene

ABHD10 (Abhydrolase Domain Containing 10) is a Protein Coding gene. Among its related pathways are Metabolism and Porphyrin and chlorophyll metabolism. GO annotations related to this gene include serine-type peptidase activity and hydrolase activity, hydrolyzing O-glycosyl compounds.

UniProtKB/Swiss-Prot for ABHD10 Gene

  • Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate.

Additional gene information for ABHD10 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD10 Gene

Genomics for ABHD10 Gene

Regulatory Elements for ABHD10 Gene

Enhancers for ABHD10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H111931 1.6 FANTOM5 Ensembl ENCODE dbSUPER 16.6 -44.1 -44109 7.2 TBP FOXA2 JUN FEZF1 ZNF664 HIC1 POLR2A FOS MAFK TCF7L2 ABHD10 PLCXD2 PLCXD2-AS1 SLC35A5 PHLDB2 GC03P111896
GH03H111922 1.4 Ensembl ENCODE dbSUPER 15.1 -54.1 -54105 5.2 PKNOX1 FOXA2 FEZF1 RAD21 RFX5 YY1 SCRT2 RCOR1 CEBPB REST ABHD10 PLCXD2-AS1 CD200 SLC35A5 GC03P111896
GH03H111858 1.7 FANTOM5 ENCODE dbSUPER 10.3 -116.3 -116267 8.6 SIN3A FEZF1 BRCA1 ZNF2 YY1 GLIS2 ATF7 RUNX3 SP3 SP5 ABHD10 PLCXD2 TAGLN3 PLCXD2-AS1 PHLDB2 SLC9C1 LOC105374040 GC03P111896
GH03H112095 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.5 +118.2 118181 2.7 PKNOX1 ATF1 INSM2 KLF17 SIN3A FEZF1 BRCA1 RFX5 ZNF366 ZSCAN5C SLC9C1 ABHD10 C3orf52 GC03P112114
GH03H111965 1.3 Ensembl ENCODE dbSUPER 11.2 -11.7 -11703 2.5 ELF3 CTCF ZSCAN4 MAX ZNF384 RAD21 ZNF7 ZNF664 ZNF366 SCRT2 ABHD10 PLCXD2 GC03P111896
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ABHD10 on UCSC Golden Path with GeneCards custom track

Promoters for ABHD10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for ABHD10 Gene

Genomic Locations for ABHD10 Gene
14,493 bases
Plus strand

Genomic View for ABHD10 Gene

Genes around ABHD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABHD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABHD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD10 Gene

Proteins for ABHD10 Gene

  • Protein details for ABHD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mycophenolic acid acyl-glucuronide esterase, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B7Z6A8
    • C9IZX5
    • D3DN63
    • Q8TCF9

    Protein attributes for ABHD10 Gene

    306 amino acids
    Molecular mass:
    33933 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABHD10 Gene


neXtProt entry for ABHD10 Gene

Post-translational modifications for ABHD10 Gene

  • Ubiquitination at Lys200
  • Modification sites at PhosphoSitePlus

Other Protein References for ABHD10 Gene

No data available for DME Specific Peptides for ABHD10 Gene

Domains & Families for ABHD10 Gene

Gene Families for ABHD10 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for ABHD10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AB hydrolase superfamily.
  • Belongs to the AB hydrolase superfamily.
genes like me logo Genes that share domains with ABHD10: view

Function for ABHD10 Gene

Molecular function for ABHD10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Mycophenolic acid O-acyl-glucuronide + H(2)O = mycophenolate + D-glucuronate.
UniProtKB/Swiss-Prot Function:
Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate.

Enzyme Numbers (IUBMB) for ABHD10 Gene

Phenotypes From GWAS Catalog for ABHD10 Gene

Gene Ontology (GO) - Molecular Function for ABHD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds TAS --
GO:0016787 hydrolase activity IEA --
GO:0102390 mycophenolic acid acyl-glucuronide esterase activity IEA --
genes like me logo Genes that share ontologies with ABHD10: view
genes like me logo Genes that share phenotypes with ABHD10: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABHD10 Gene

Localization for ABHD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABHD10 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABHD10 gene
Compartment Confidence
mitochondrion 5
cytosol 5
peroxisome 2
nucleus 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ABHD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005759 mitochondrial matrix TAS --
GO:0005829 cytosol IDA 22294686
genes like me logo Genes that share ontologies with ABHD10: view

Pathways & Interactions for ABHD10 Gene

genes like me logo Genes that share pathways with ABHD10: view

Pathways by source for ABHD10 Gene

Gene Ontology (GO) - Biological Process for ABHD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019391 glucuronoside catabolic process IDA 22294686
GO:0052695 cellular glucuronidation TAS --
genes like me logo Genes that share ontologies with ABHD10: view

No data available for SIGNOR curated interactions for ABHD10 Gene

Drugs & Compounds for ABHD10 Gene

(3) Drugs for ABHD10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mycophenolic acid Approved Pharma 972
Water Approved Pharma 0
D-Glucuronic acid Experimental Pharma 0

(1) Additional Compounds for ABHD10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Mycophenolic acid O-acyl-glucuronide
genes like me logo Genes that share compounds with ABHD10: view

Transcripts for ABHD10 Gene

Unigene Clusters for ABHD10 Gene

Abhydrolase domain containing 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD10 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: -
SP2: - -

Relevant External Links for ABHD10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ABHD10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ABHD10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ABHD10 Gene

This gene is overexpressed in Salivary gland (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABHD10 Gene

Protein tissue co-expression partners for ABHD10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ABHD10 Gene:


SOURCE GeneReport for Unigene cluster for ABHD10 Gene:


Evidence on tissue expression from TISSUES for ABHD10 Gene

  • Liver(4.4)
  • Nervous system(3.3)
genes like me logo Genes that share expression patterns with ABHD10: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABHD10 Gene

Orthologs for ABHD10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ABHD10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ABHD10 33 34
  • 99.89 (n)
(Bos Taurus)
Mammalia ABHD10 33 34
  • 86.6 (n)
(Canis familiaris)
Mammalia ABHD10 33 34
  • 85.46 (n)
(Mus musculus)
Mammalia Abhd10 16 34 33
  • 81.67 (n)
(Rattus norvegicus)
Mammalia Abhd10 33
  • 80.94 (n)
(Monodelphis domestica)
Mammalia ABHD10 34
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia ABHD10 34
  • 68 (a)
(Gallus gallus)
Aves ABHD10 33 34
  • 67.73 (n)
(Anolis carolinensis)
Reptilia ABHD10 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd10 33
  • 68.21 (n)
Str.11875 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.14582 33
(Danio rerio)
Actinopterygii abhd10a 33 34
  • 62.21 (n)
abhd10b 34
  • 59 (a)
wufb10b08 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4816 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
Species where no ortholog for ABHD10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABHD10 Gene

Gene Tree for ABHD10 (if available)
Gene Tree for ABHD10 (if available)

Paralogs for ABHD10 Gene Pseudogenes for ABHD10 Gene

genes like me logo Genes that share paralogs with ABHD10: view

No data available for Paralogs for ABHD10 Gene

Variants for ABHD10 Gene

Sequence variations from dbSNP and Humsavar for ABHD10 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000133176 -- 111,977,775(+) GGTTG(A/T)TGCTT upstream-variant-2KB
rs1000244554 -- 111,978,749(+) CCATC(C/T)AGGAC upstream-variant-2KB
rs1000430212 -- 111,989,770(+) CATTA(A/T)TTTTA intron-variant
rs1000515210 -- 111,988,786(+) GGTCT(C/T)GCCAT intron-variant
rs1000761831 -- 111,988,319(+) AACTT(-/A)ATCTC intron-variant

Variation tolerance for ABHD10 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABHD10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ABHD10 Gene

Disorders for ABHD10 Gene

Relevant External Links for ABHD10

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ABHD10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABHD10 Gene

Publications for ABHD10 Gene

  1. Human α/β hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver. (PMID: 22294686) Iwamura A … Yokoi T (The Journal of biological chemistry 2012) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for ABHD10 Gene

Sources for ABHD10 Gene

Loading form....