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Aliases for ABHD10 Gene

Aliases for ABHD10 Gene

  • Abhydrolase Domain Containing 10 2 3
  • Alpha/Beta Hydrolase Domain-Containing Protein 10 4
  • Abhydrolase Domain-Containing Protein 10 4
  • EC 3.1.1.93 4

External Ids for ABHD10 Gene

Previous GeneCards Identifiers for ABHD10 Gene

  • GC03P113181
  • GC03P111697
  • GC03P109073

Summaries for ABHD10 Gene

Entrez Gene Summary for ABHD10 Gene

  • This gene encodes a mitochondrially-localized enzyme that acts in liver cells as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

GeneCards Summary for ABHD10 Gene

ABHD10 (Abhydrolase Domain Containing 10) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity, hydrolyzing O-glycosyl compounds.

UniProtKB/Swiss-Prot for ABHD10 Gene

  • Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD10 Gene

Genomics for ABHD10 Gene

Regulatory Elements for ABHD10 Gene

Genomic Location for ABHD10 Gene

Start:
111,978,876 bp from pter
End:
111,993,368 bp from pter
Size:
14,493 bases
Orientation:
Plus strand

Genomic View for ABHD10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABHD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD10 Gene

Proteins for ABHD10 Gene

  • Protein details for ABHD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUJ1-ABHDA_HUMAN
    Recommended name:
    Mycophenolic acid acyl-glucuronide esterase, mitochondrial
    Protein Accession:
    Q9NUJ1
    Secondary Accessions:
    • B7Z6A8
    • C9IZX5
    • D3DN63
    • Q8TCF9

    Protein attributes for ABHD10 Gene

    Size:
    306 amino acids
    Molecular mass:
    33933 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABHD10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABHD10 Gene

Proteomics data for ABHD10 Gene at MOPED

Post-translational modifications for ABHD10 Gene

  • Ubiquitination at Lys200
  • Modification sites at PhosphoSitePlus

Other Protein References for ABHD10 Gene

No data available for DME Specific Peptides for ABHD10 Gene

Domains for ABHD10 Gene

Gene Families for ABHD10 Gene

HGNC:
  • ABHD :Abhydrolase domain containing

Protein Domains for ABHD10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NUJ1

UniProtKB/Swiss-Prot:

ABHDA_HUMAN :
  • Q9NUJ1
Family:
  • Belongs to the AB hydrolase superfamily.
genes like me logo Genes that share domains with ABHD10: view

Function for ABHD10 Gene

Molecular function for ABHD10 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Mycophenolic acid O-acyl-glucuronide + H(2)O = mycophenolate + D-glucuronate.
UniProtKB/Swiss-Prot Function: Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate.

Enzyme Numbers (IUBMB) for ABHD10 Gene

Gene Ontology (GO) - Molecular Function for ABHD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds IDA 22294686
GO:0008236 serine-type peptidase activity --
genes like me logo Genes that share ontologies with ABHD10: view

Phenotypes for ABHD10 Gene

GenomeRNAi human phenotypes for ABHD10:
genes like me logo Genes that share phenotypes with ABHD10: view

miRNA for ABHD10 Gene

miRTarBase miRNAs that target ABHD10

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ABHD10 Gene

Localization for ABHD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABHD10 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABHD10 Gene COMPARTMENTS Subcellular localization image for ABHD10 gene
Compartment Confidence
cytosol 4
mitochondrion 4
peroxisome 2
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ABHD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005829 cytosol IDA 22294686
genes like me logo Genes that share ontologies with ABHD10: view

Pathways for ABHD10 Gene

SuperPathways for ABHD10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ABHD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0019391 glucuronoside catabolic process IDA 22294686
genes like me logo Genes that share ontologies with ABHD10: view

No data available for Pathways by source for ABHD10 Gene

Transcripts for ABHD10 Gene

Unigene Clusters for ABHD10 Gene

Abhydrolase domain containing 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD10 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: -
SP2: - -
SP3:

Relevant External Links for ABHD10 Gene

GeneLoc Exon Structure for
ABHD10
ECgene alternative splicing isoforms for
ABHD10

Expression for ABHD10 Gene

mRNA expression in normal human tissues for ABHD10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABHD10 Gene

SOURCE GeneReport for Unigene cluster for ABHD10 Gene Hs.477115

genes like me logo Genes that share expressions with ABHD10: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ABHD10 Gene

Orthologs for ABHD10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ABHD10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABHD10 35
  • 99.89 (n)
  • 100 (a)
ABHD10 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ABHD10 35
  • 86.6 (n)
  • 84.64 (a)
ABHD10 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABHD10 35
  • 85.46 (n)
  • 83.61 (a)
ABHD10 36
  • 48 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abhd10 35
  • 81.67 (n)
  • 77.66 (a)
Abhd10 16
Abhd10 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABHD10 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABHD10 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abhd10 35
  • 80.94 (n)
  • 77.4 (a)
chicken
(Gallus gallus)
Aves ABHD10 35
  • 67.73 (n)
  • 67.97 (a)
ABHD10 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABHD10 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14582 35
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd10 35
  • 68.21 (n)
  • 65.25 (a)
Str.11875 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4816 35
zebrafish
(Danio rerio)
Actinopterygii abhd10a 35
  • 62.21 (n)
  • 64.5 (a)
abhd10a 36
  • 45 (a)
OneToMany
abhd10b 36
  • 59 (a)
OneToMany
wufb10b08 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToOne
Species with no ortholog for ABHD10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABHD10 Gene

ENSEMBL:
Gene Tree for ABHD10 (if available)
TreeFam:
Gene Tree for ABHD10 (if available)

Paralogs for ABHD10 Gene

Pseudogenes.org Pseudogenes for ABHD10 Gene

genes like me logo Genes that share paralogs with ABHD10: view

No data available for Paralogs for ABHD10 Gene

Variants for ABHD10 Gene

Sequence variations from dbSNP and Humsavar for ABHD10 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs510549 -- 111,981,458(-) TGTAT(C/T)CTAAA intron-variant
rs703270 -- 111,980,217(-) ATTCT(C/T)ACTAT intron-variant
rs703271 -- 111,978,046(-) GTTGT(C/G)AAGTA upstream-variant-2KB
rs703272 -- 111,978,256(-) AAATA(C/T)AATTC upstream-variant-2KB
rs712524 -- 111,977,058(-) tccca(A/C)agtgc upstream-variant-2KB

Relevant External Links for ABHD10 Gene

HapMap Linkage Disequilibrium report
ABHD10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ABHD10 Gene

Disorders for ABHD10 Gene

Relevant External Links for ABHD10

Genetic Association Database (GAD)
ABHD10
Human Genome Epidemiology (HuGE) Navigator
ABHD10
genes like me logo Genes that share disorders with ABHD10: view

No data available for UniProtKB/Swiss-Prot for ABHD10 Gene

Publications for ABHD10 Gene

  1. Human alpha/beta hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl- glucuronide in liver. (PMID: 22294686) Iwamura A. … Yokoi T. (J. Biol. Chem. 2012) 2 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for ABHD10 Gene

  • antibodies-online proteins for ABHD10
  • antibodies-online antibodies for ABHD10
  • antibodies-online kits for ABHD10

Sources for ABHD10 Gene

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