ABHD10 Gene
protein-coding GIFtS: 46
GCID: GC03P111697
|
|
abhydrolase domain containing 10
| |
Aliases
for ABHD10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Abhydrolase Domain Containing 101 2 | | Mycophenolic Acid Acyl-Glucuronide Esterase, Mitochondrial2 | | FLJ113421 | | EC 3.1.1.933 | | Abhydrolase Domain-Containing Protein 10, Mitochondrial2 | | Abhydrolase Domain-Containing Protein 103 | | Alpha/Beta Hydrolase Domain-Containing Protein 10, Mitochondrial2 | | Alpha/Beta Hydrolase Domain-Containing Protein 103 |
Export aliases for ABHD10 gene to outside databasesPrevious GC identifers: GC03P113181 GC03P109073 |
Summaries
for ABHD10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ABHD10:
This gene encodes a mitochondrially-localized enzyme that acts in liver cells as a hydrolase. The encoded proteinremoves glucuronide from mycophenolic acid acyl-glucuronide. There is a pseudogene for this gene on chromosome 6.Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jan 2013)
UniProtKB/Swiss-Prot: ABHDA_HUMAN, Q9NUJ1Function: Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressantdrug mycophenolate
|
Genomic Views
for ABHD10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ABHD10 gene promoter:
GR C/EBPbeta USF1 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 USF-1 IRF-7A GR-alpha ZID
Other transcription factors
Search SABiosciences Chromatin IP Primers for ABHD10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABHD10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q13.2 Ensembl cytogenetic band: 3q13.2 HGNC cytogenetic band: 3q13.2ABHD10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P111697: view genomic region
(about GC identifiers)
Start:
|
111,697,828 bp from pter |
End:
|
111,712,210 bp from pter |
Size:
|
14,383 bases |
Orientation:
|
plus strand |
|
Proteins
for ABHD10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ABHDA_HUMAN, Q9NUJ1 (See
protein sequence)Recommended Name: Mycophenolic acid acyl-glucuronide esterase, mitochondrial precursor Size: 306 amino acids; 33933 Da
Subcellular location: Mitochondrion (Potential)
Secondary accessions: D3DN63 Q8TCF9Explore the universe of human proteins at neXtProt for ABHD10: NX_Q9NUJ1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NUJ1
ABHD10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001258998.1 NP_060864.1
ENSEMBL proteins: ENSP00000418162 ENSP00000273359 ENSP00000417880 ENSP00000418973 ENSP00000442932
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ABHD10 for ontologies About GeneDecksing
ABHD10 Antibody Products:
Assay Products for ABHD10: |
Protein
Domains /
Families
for ABHD10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9NUJ1 1 Blocks protein family: IPB003089 Alpha/beta hydrolase fold signature
UniProtKB/Swiss-Prot: ABHDA_HUMAN, Q9NUJ1Similarity: Belongs to the AB hydrolase superfamily |
Function
for ABHD10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ABHDA_HUMAN, Q9NUJ1Function: Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressantdrug mycophenolateCatalytic activity: Mycophenolic acid O-acyl-glucuronide + H(2)O = mycophenolate + D-glucuronateEnzyme Number (IUBMB): EC 3.1.1.931
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD10
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABHD10 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
IDA | -- | | GO:0008236 | serine-type peptidase activity |
-- | -- | | GO:0016787 | hydrolase activity |
-- | -- |
ABHD10 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ABHD10:
|
Pathways & Interactions
for ABHD10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ABHD10
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for ABHD10 (Q9NUJ13 ENSP000002733594) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
-- | -- | | GO:0019391 | glucuronoside catabolic process |
IDA | -- |
ABHD10 for ontologies About GeneDecksing
|
Drugs & Compounds
for ABHD10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ABHD10
Search CenterWatch for drugs/clinical trials and news about ABHD10 / ABHDA
|
Transcripts
for ABHD10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ABHD10 gene (2 alternative transcripts): NM_001272069.1 NM_018394.3 Unigene Cluster for ABHD10: Abhydrolase domain containing 10 Hs.743466 [show with all ESTs]Unigene Representative Sequence: NM_0183946 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000491580 ENST00000497293 ENST00000273359(uc003dyk.4 uc011bhq.2)
ENST00000493784 ENST00000494817 ENST00000534857
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD10 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ABHD10
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ABHD10 (NM_018394) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ABHD10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ABHD10 |
Additional cDNA sequence: AK002204.1 AK093591.1 AK300018.1 AL713726.1 BC014516.2 8 DOTS entries: DT.317371 DT.100779651 DT.95173835 DT.120872177 DT.97845041 DT.99927685 DT.100779652 DT.120872180 24/232 AceView cDNA sequences (see all 232): BE670360 N81012 BU190175 AI032182 AW779685 BQ959475 BE219556 BM761395 AI478425 AI435002 BI916347 BM831397 BI765516 BG390295 AA947140 BQ924203 AI261450 AW271801 AW611570 BX358216 BM476325 AA774295 AA113264 AI521709
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ABHD10 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ABHD10
|
Expression
for ABHD10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ABHD10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ABHD10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ABHD10
SOURCE GeneReport for Unigene cluster: Hs.743466
SABiosciences Custom PCR Arrays for ABHD10
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ABHD10
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABHD10 |
Orthologs
for ABHD10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ABHD10 gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Abhd101 , 5 |
abhydrolase domain containing 101, 5 |
81.64(n)1
77.36(a)1 |
|
16 (30.04 cM)5
2130121 NM_172511.31 NP_766099.31
457297255 |
chicken
(Gallus gallus) |
Aves |
ABHD101 |
abhydrolase domain containing 10 |
69.79(n)
69.92(a) |
|
418419 XM_416633.3 XP_416633.3 |
lizard
(Anolis carolinensis) |
Reptilia |
ABHD106 |
-- |
65(a) |
1 ↔ 1 |
3(167719536-167722890) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.145822 |
Xenopus laevis transcribed sequence with weak similarity more |
74.88(n) |
|
BQ731168.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb10b082 |
Transcribed sequence with weak similarity to protein more |
73.94(n) |
|
AL922340.1 |
ENSEMBL Gene Tree for ABHD10 (if available)
TreeFam Gene Tree for ABHD10 (if available) |
Paralogs
for ABHD10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ABHD10 gene
ABHD10 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ABHD10
PGOHUM00000243735
|
Genomic Variants
for ABHD10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ABHD10 (111697828 - 111712210 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ABHD10: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABHD10 |
|
Disorders
/ Diseases
for ABHD10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ABHD10 for disorders About GeneDecksing
2  diseases for ABHD10: About MalaCardshepatocellular carcinoma carcinoma
Human Genome Epidemiology (HuGE) Navigator: ABHD10 (2 documents)
Export disorders for ABHD10 gene to outside databases
|
Publications
for ABHD10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ABHD10 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with ABHD10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human a/b hydrolase domain containing 10 (ABHD10) is r esponsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver. (PubMed id 22294686)1, 2, 3 Iwamura A....Yokoi T. (2012)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The emerging role of human esterases. (PubMed id 22813719)1 Fukami T. and Yokoi T. (2012)
- Competitive activity-based protein profiling identifie s aza-b-lactams as a versatile chemotype for serine hydrolase inhibition. (PubMed id 22400490)1 Zuhl A.M....Cravatt B.F. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for ABHD10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ABHD10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ABHD10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ABHD10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ABHD10 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ABHD10 gene:
Search GeneIP for patents involving ABHD10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ABHD10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ABHD10 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABHD10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABHD10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABHD10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABHD10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABHD10 |
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|
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