Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ABHD1 Gene

Aliases for ABHD1 Gene

  • Abhydrolase Domain Containing 1 2 3
  • Lung Alpha/Beta Hydrolase 1 3 4
  • LABH1 3 4
  • EC 3.1.1.- 4
  • EC 3.1.1 63

External Ids for ABHD1 Gene

Previous GeneCards Identifiers for ABHD1 Gene

  • GC02P027268
  • GC02P027439
  • GC02P027321
  • GC02P027258
  • GC02P027349
  • GC02P027088

Summaries for ABHD1 Gene

Entrez Gene Summary for ABHD1 Gene

  • This gene is a member of the AB hydrolase superfamily and encodes a protein with an alpha/beta hydrolase fold. This domain is common to a number of hydrolytic enzymes of widely differing phylogenetic origins and catalytic functions. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABHD1 Gene

ABHD1 (Abhydrolase Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include carboxylic ester hydrolase activity. An important paralog of this gene is ABHD2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD1 Gene

Genomics for ABHD1 Gene

Regulatory Elements for ABHD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ABHD1 Gene

Chromosome:
2
Start:
27,123,780 bp from pter
End:
27,130,991 bp from pter
Size:
7,212 bases
Orientation:
Plus strand

Genomic View for ABHD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABHD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD1 Gene

Proteins for ABHD1 Gene

  • Protein details for ABHD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SE0-ABHD1_HUMAN
    Recommended name:
    Abhydrolase domain-containing protein 1
    Protein Accession:
    Q96SE0
    Secondary Accessions:
    • B3KSF6
    • E9PDR9
    • Q05BY3
    • Q53SZ1
    • Q8IXQ7

    Protein attributes for ABHD1 Gene

    Size:
    405 amino acids
    Molecular mass:
    45207 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABHD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABHD1 Gene

Proteomics data for ABHD1 Gene at MOPED

Selected DME Specific Peptides for ABHD1 Gene

Post-translational modifications for ABHD1 Gene

  • Glycosylation at Asn 10
  • Modification sites at PhosphoSitePlus

Other Protein References for ABHD1 Gene

Antibody Products

Domains & Families for ABHD1 Gene

Gene Families for ABHD1 Gene

Protein Domains for ABHD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96SE0

UniProtKB/Swiss-Prot:

ABHD1_HUMAN :
  • Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.
Family:
  • Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.
genes like me logo Genes that share domains with ABHD1: view

Function for ABHD1 Gene

Enzyme Numbers (IUBMB) for ABHD1 Gene

Gene Ontology (GO) - Molecular Function for ABHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with ABHD1: view

Phenotypes for ABHD1 Gene

GenomeRNAi human phenotypes for ABHD1:
genes like me logo Genes that share phenotypes with ABHD1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABHD1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ABHD1 Gene

Localization for ABHD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABHD1 Gene

Membrane; Single-pass type II membrane protein.

Gene Ontology (GO) - Cellular Components for ABHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane NAS 12735795
genes like me logo Genes that share ontologies with ABHD1: view

No data available for Subcellular locations from COMPARTMENTS for ABHD1 Gene

Pathways & Interactions for ABHD1 Gene

SuperPathways for ABHD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ABHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with ABHD1: view

No data available for Pathways by source and SIGNOR curated interactions for ABHD1 Gene

Drugs & Compounds for ABHD1 Gene

No Compound Related Data Available

Transcripts for ABHD1 Gene

Unigene Clusters for ABHD1 Gene

Abhydrolase domain containing 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABHD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8
SP1: -
SP2: - - - -
SP3: - -
SP4:
SP5:

Relevant External Links for ABHD1 Gene

GeneLoc Exon Structure for
ABHD1
ECgene alternative splicing isoforms for
ABHD1

Expression for ABHD1 Gene

mRNA expression in normal human tissues for ABHD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABHD1 Gene

This gene is overexpressed in Testis (x30.0).

SOURCE GeneReport for Unigene cluster for ABHD1 Gene Hs.375791

mRNA Expression by UniProt/SwissProt for ABHD1 Gene

Q96SE0-ABHD1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with ABHD1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ABHD1 Gene

Orthologs for ABHD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABHD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ABHD1 35
  • 82.59 (n)
  • 78.22 (a)
ABHD1 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ABHD1 35
  • 84.77 (n)
  • 77.53 (a)
ABHD1 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ABHD1 35
  • 99.26 (n)
  • 97.78 (a)
ABHD1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abhd1 35
  • 81.19 (n)
  • 79.46 (a)
mouse
(Mus musculus)
Mammalia Abhd1 16
oppossum
(Monodelphis domestica)
Mammalia ABHD1 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ABHD1 36
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia abhd1-prov 35
zebrafish
(Danio rerio)
Actinopterygii si:dkey-230a20.2 36
  • 22 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Hydr1 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C44C1.5 36
  • 32 (a)
ManyToMany
Y60A3A.7 36
  • 32 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR149C 35
  • 42.32 (n)
  • 32.73 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D06039g 35
  • 43.19 (n)
  • 31.59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YMR210W 35
  • 42.37 (n)
  • 32.53 (a)
-- 36
  • 21 (a)
ManyToMany
EEB1 36
  • 21 (a)
ManyToMany
EHT1 36
  • 21 (a)
ManyToMany
-- 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G34340 35
  • 42.14 (n)
  • 27.67 (a)
rice
(Oryza sativa)
Liliopsida Os05g0432600 35
  • 44.06 (n)
  • 29.02 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01302 35
  • 43.96 (n)
  • 28.48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2629 36
  • 32 (a)
OneToMany
Species with no ortholog for ABHD1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ABHD1 Gene

ENSEMBL:
Gene Tree for ABHD1 (if available)
TreeFam:
Gene Tree for ABHD1 (if available)

Paralogs for ABHD1 Gene

Paralogs for ABHD1 Gene

(1) SIMAP similar genes for ABHD1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ABHD1: view

Variants for ABHD1 Gene

Sequence variations from dbSNP and Humsavar for ABHD1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1866561 -- 27,128,411(+) TCAGG(A/G)AAGTG intron-variant
rs3795960 -- 27,128,725(+) GACAA(C/T)GGATG intron-variant
rs3806521 -- 27,123,333(+) CTGTA(C/T)GAGAC upstream-variant-2KB
rs3806522 -- 27,123,640(+) TGTCT(C/G)GGGCT upstream-variant-2KB
rs4665946 -- 27,125,063(+) TTGAA(A/C)CTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABHD1 Gene

Variant ID Type Subtype PubMed ID
nsv455974 CNV Loss 19166990
nsv817673 CNV Gain 17921354
nsv833603 CNV Loss 17160897
nsv873753 CNV Loss 21882294

Variation tolerance for ABHD1 Gene

Residual Variation Intolerance Score: 43.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.68; 78.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ABHD1 Gene

HapMap Linkage Disequilibrium report
ABHD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABHD1 Gene

Disorders for ABHD1 Gene

Relevant External Links for ABHD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ABHD1
genes like me logo Genes that share disorders with ABHD1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABHD1 Gene

Publications for ABHD1 Gene

  1. Cloning and tissue distribution of three murine alpha/beta hydrolase fold protein cDNAs. (PMID: 11922611) Edgar A.J. … Polak J.M. (Biochem. Biophys. Res. Commun. 2002) 2 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for ABHD1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ABHD1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for ABHD1
  • Block miRNA regulation of ABHD1 using miScript Target Protectors

Sources for ABHD1 Gene

Back to Top

Content