V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

ABCG8 Gene

protein-coding GIFtS: 59

GC02P043977

ATP-binding cassette, sub-family G (WHITE), member 8
(Previous names: ATP-binding cassette, sub-family G (WHITE), member 8 (sterolin 2) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
GBD4 ^¹, ², ⁵
MGC142217 ^²
STSL ^²
Sterolin-2 ^³

Descriptions
ATP-binding cassette sub-family G member 8 ^²
ATP-binding cassette, sub-family G (WHITE), member 8 ^²
ATP-binding cassette, sub-family G (WHITE), member 8 (sterolin 2) ^¹
ATP-binding cassette, sub-family G, member 8 ^¹
ATP-binding cassette, subfamily G, member 8 ^²
sterolin 2 ^²

External Ids
HGNC: 13887¹
Entrez Gene: 64241²
UniProtKB: Q9H221³
Ensembl: ENSG00000143921⁷

Search outside databases for aliases for ABCG8 gene

Previous GC identifers: GC02P044065 GC02P044234 GC02P044040

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ABCG8:

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC)

transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.

ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,

White). This protein is a member of the White subfamily. The protein encoded by this gene

functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of

cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal

lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This

gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5.

Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been

observed in patients with sitosterolemia. [provided by RefSeq]

UniProtKB/Swiss-Prot: ABCG8_HUMAN, Q9H221

Function: Transporter that appears to play an indispensable role in the selective transport of the

dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the

liver into bile

Gene Wiki entry for ABCG8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ABCG8 gene

Entrez Gene cytogenetic band: 2p21 Ensembl cytogenetic band: 2p21 HGNC cytogenetic band: 2p21

ABCG8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P043977: (about GC identifiers)

Start:	43,919,607 bp from pter
End:	43,959,109 bp from pter
Size:	39,503 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_022184.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ABCG8_HUMAN, Q9H221 (See protein sequence)

Recommended Name: ATP-binding cassette sub-family G member 8

Size: 673 amino acids; 75679 Da

Subunit: May form heterodimers with ABCG5 or be tightly coupled to ABCG5 along a pathway regulating

diatery-sterol absorption and excretion

Subcellular location: Membrane; Multi-pass membrane protein (Probable)

Caution: Seems to have a defective ATP-binding region

Secondary accessions: Q53QN8

Alternative splicing: 2 isoforms: Q9H221-1 Q9H221-2

REFSEQ proteins: NP_071882.1

ENSEMBL proteins:

ENSP00000272286

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ABCG8)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for ABCG8:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ABCG8
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ABCG8), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for ABCG8

Assays for ABCG8:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9H221

ProtoNet protein and cluster: Q9H221

UniProtKB/Swiss-Prot: ABCG8_HUMAN, Q9H221

Similarity: Belongs to the ABC transporter family. ABCG (White) subfamily

Similarity: Contains 1 ABC transmembrane type-2 domain

Similarity: Contains 1 ABC transporter domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCG8)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCG8)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_022437

Applied Biosystems Silencer® siRNAs for ABCG8

Sigma-Aldrich siRNA and siRNA Panels for ABCG8

Sigma-Aldrich shRNA for ABCG8

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_022437
Myc/DDK tagged cDNA clone in CMV expression vector: NM_022437
untagged cDNA clone in CMV expression vector: NM_022437

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_022437

UniProtKB/Swiss-Prot: ABCG8_HUMAN, Q9H221

Function: Transporter that appears to play an indispensable role in the selective transport of the

dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the

liver into bile

3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Abcg8):

digestive/alimentary

homeostasis/metabolism

liver/biliary system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005524	ATP binding	IEA	--
GO:0016887	ATPase activity	IEA	--
GO:0046982	protein heterodimerization activity	IPI	16870176

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

4 Sigma-Aldrich "Your Favorite Gene" Pathways for ABCG8 (Your Favorite Gene powered by Ingenuity)

FXR/RXR Activation
Hepatic Cholestasis
LXR/RXR Activation
LPS/IL-1 Mediated Inhibition of RXR Function

GeneDecks ABCG8 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ABCG8

5/18 Interacting proteins for ABCG8 (ENSP00000272286³ Q9H221²) via UniProtKB, MINT, and/or STRING (see all 18 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABCG5	Q9H222²	MINT-2840569 MINT-2840517
NR1H3	ENSP00000342470³	STRING (score=.955)
SREBF2	ENSP00000354476³	STRING (score=.953)
NR1H4	ENSP00000188403³	STRING (score=.947)
CYP7A1	ENSP00000301645³	STRING (score=.879)

About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	IEA	--
GO:0015914	phospholipid transport	IEA	--
GO:0015918	sterol transport	IEA	--
GO:0042632	cholesterol homeostasis	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ABCG8
8 Novoseek chemical compound relationships for ABCG8 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sterol	89.51	48	15520451 (3), 15044450 (3), 15860120 (2), 12208868 (2) (see all 30)
lathosterol	81.99	2	15331430 (1), 15210841 (1)
cholesterol	74.23	75	15175352 (4), 18581044 (3), 16250035 (3), 18522623 (2) (see all 39)
cholestanol	54.92	1	15175352 (1)
atp	43.18	17	11668628 (2), 16893193 (2), 14657202 (1), 15121760 (1) (see all 13)
lipid	34.37	6	15311998 (1), 15860120 (1), 17098593 (1), 16980816 (1) (see all 5)
phospholipid	6.69	1	16250035 (1)
glucose	0.00	1	17543849 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ABCG8)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ABCG8)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_022437

Sigma-Aldrich siRNA and siRNA Panels for ABCG8

Sigma-Aldrich shRNA for ABCG8

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_022437

REFSEQ mRNAs for ABCG8 gene:

NM_022437.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_022437

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_022437
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_022437
                                 untagged cDNA clone in CMV expression vector: NM_022437

Additional cDNA sequence:

AF320294.1 AF324494.1 BC113657.1 BC143564.1

4 DOTS entries:

DT.97830216 DT.102880 DT.95201817 DT.75131703

21 AceView cDNA sequences:

NM_022437 AF320294 AA700584 BX096032 AA034046 BX482362 CB162405 AF324494

H55780 BX481838 AA701645 AA033788 BX109661 R89160 R89063 T84531

H60686 T91380 H55873 H59871 R00110

highest scoring ESTs for ABCG8:

AF320294 AF324494 T91380 BX096032 BX481838 BX482362 NM_022437 R89160 T84531 AA033788

Unigene Cluster for ABCG8:

ATP-binding cassette, sub-family G (WHITE), member 8

Hs.413931 [show with all ESTs]

Unigene Representative Sequence: NM_022437

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000272286

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ABCG8 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ABCG8

¹ / ² / ³

3 probe-sets matching ABCG8 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
51189_at²^{, 3}	U95-C	1	0.75	1.00	1.00	1.00	T91380	0.80	1.00	0.91	1
231751_at²^{, 3}	U133-B	1	1.00	1.00	--	--	NM_022437	0.60	1.00	0.82	1
231751_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ABCG8 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGCTCCAAAA

SOURCE GeneReport for Unigene cluster: Hs.413931
UniProtKB/Swiss-Prot: ABCG8_HUMAN, Q9H221
Tissue specificity: Strongly expressed in the liver, lower levels in the small intestine and colon.
Detectable in a wide variety of human tissues

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ABCG8 gene from 5/14 species (see all 14 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ABCG8¹	--	ATP-binding cassette, sub-family G (WHITE), member more	84.74(n) 83.72(a)	474571 XM_531799.2 XP_531799.2
chimpanzee (Pan troglodytes)	ABCG8¹	--	ATP-binding cassette, sub-family G (WHITE), member more	99.36(n) 99.11(a)	470363 XM_525745.2 XP_525745.2
cow (Bos taurus)	ABCG8¹	--	ATP-binding cassette, sub-family G (WHITE), member more	85(n) 82.21(a)	508829 NM_001024663.1 NP_001019834.1
rat (Rattus norvegicus)	Abcg8¹	--	ATP-binding cassette, sub-family G (WHITE), member more	81.99(n) 79.91(a)	155192 NM_130414.2 NP_569098.2
mouse (Mus musculus)	Abcg8^{1, 5}	17 (54.50 cM)⁵	ATP-binding cassette, sub-family G (WHITE), member more^{1, 5}	82.09(n)¹ 81.85(a)¹	67470¹ NM_026180.2¹ NP_080456.1¹ AF324495⁵ AF351799⁵ (see all 25)

About this table Species with no ortholog for ABCG8

ENSEMBL Gene Tree for ABCG8

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ABCG8 gene

ABCG5²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/384 NCBI SNPs in ABCG8 are shown (see all 384 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 99)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4148211^1,2	A,C,F,H	43925247(+)	`CAACTG/ACCAGG`	1	C/Y	mis¹ ese³		11		EU EA WA NA	958
	rs4148217^1,2	A,C,F,H	43952937(+)	`GTTTAC/AGACGC`	1	K/T	mis¹ ese³		17		EA EU WA NA	1524
	rs6544718^1,2	A,C,F,H	43958429(+)	`CAGTGC/TCATGG`	1	V/A	mis¹ ese³		14		MN CSAM EA EU WA NA	1312
--	rs9282574^1,2	C,F,H	43933063(+)	`TGTACG/ATGCGG`	1	M/V	mis¹ ese³		9		MN CSAM EA EU WA	814
--	rs9282573^1,2	C,F,H	43958497(+)	`GCTTCA/GTGGTC`	1	M/V	mis¹		13		MN CSAM EA EU WA	1234
	rs17031744^1,2	F,H	43959391(+)	`AGAGTT/CGCATT`	1	--	ng3¹		7		NA EU EA WA	560
--	rs2954801^1,2	A,C	43959561(+)	`TCCGAC/TGGTTT`	1	--	ng3¹		0	--	--	--	--
	rs11676159^1,2	H	43959320(+)	`CCTTAG/TGAGTT`	1	--	ng3¹		4		EU EA WA	418
	rs35518570^1,2	F	43933323(+)	`GCTGGC/TCAAAG`	1	A/V	mis¹		1		NA	92
	rs4148221^1,2	C,F,H	43955995(+)	`AATGCC/TCTCTA`	1	A/A	syn¹ ese³		11		NA EU EA WA	980

About this table

HapMap Linkage Disequilibrium images for ABCG8 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605460 disorders: 210250 611465

UniProtKB/Swiss-Prot: ABCG8_HUMAN, Q9H221

Genetic variations in ABCG8 can be associated with susceptibility to gallbladder disease

type 4 (GBD4) [MIM:611465]. With an overall prevalence of 10-20%, gallstone disease

(cholelithiasis) represents one of the most frequent and economically relevant health problems of

industrialized countries

Defects in ABCG8 are a cause of sitosterolemia [MIM:210250]; also known as phytosterolemia

or shellfish sterolemia. It is a rare autosomal recessive disorder characterized by increased

intestinal absorption of all sterols including cholesterol, plant and shellfish sterols, and

decreased biliary excretion of dietary sterols into bile. Sitosterolemia patients have

hypercholesterolemia, very high levels of plant sterols in the plasma, and frequently develop

tendon and tuberous xanthomas, accelerated atherosclerosis and premature coronary artery disease

3 Novoseek disease relationships for ABCG8 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sitosterolemia	97.62	36	15040800 (4), 11668628 (3), 11893785 (1), 11907139 (1) (see all 26)
hypercholesterolemia	61.38	6	19012522 (2), 18522623 (1), 15175362 (1), 17483372 (1) (see all 5)
atherosclerosis	41.89	5	15044450 (2), 15175362 (1), 16893193 (1), 15054092 (1)

About this table

Human Gene Mutation Database: ABCG8
Genetic Association Database: ABCG8
Human Genome Epidemiology Navigator: ABCG8 (28 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/114 PubMed articles for ABCG8 gene (see all 114 ):

Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. (PubMed id 11099417)^{2, 3, 4} Berge K.E.... Hobbs H.H. (2000)
Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively. (PubMed id 11452359)^{1, 3, 4} Lu K....Patel S.B. (2001)
Mutations in ATP-cassette binding proteins G5 (ABCG5) and G8 (ABCG8) causing sitosterolemia. (PubMed id 11668628)^{1, 3, 4} Hubacek J.A.... Hobbs H.H. (2001)
Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity. (PubMed id 15175352)^{1, 3, 6} Gylling H....Miettinen T.A. (2004)
Common sequence variations in ABCG8 are related to plant sterol metabolism in healthy volunteers. (PubMed id 15520451)^{1, 3, 6} Plat J....Mensink R.P. (2005)
Polymorphisms in ABCG5 and ABCG8 transporters and plasma cholesterol levels. (PubMed id 15311998)^{1, 3, 6} Hubacek J.A....Poledne R. (2004)
Increased gallstone risk in humans conferred by common variant of hepatic ATP-binding cassette transporter for cholesterol. (PubMed id 17626266)^{1, 2, 3} Grunhage F....Lammert F. (2007)
ATP-binding cassette transporter G8 M429V polymorphism as a novel genetic marker of higher cholesterol absorption in hypercholesterolaemic Japanese subjects. (PubMed id 15816807)^{1, 3, 6} Miwa K....Mabuchi H. (2005)
ATP-binding cassette transporter G8 gene as a determinant of apolipoprotein B-100 kinetics in overweight men. (PubMed id 15331430)^{1, 3, 6} Chan D.C....van Bockxmeer F.M. (2004)
ATP binding cassette G5 C1950G polymorphism may affect blood cholesterol concentrations in humans. (PubMed id 12220438)^{1, 3, 6} Weggemans R.M....Katan M.B. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 64241	HGNC: 13887	AceView: ABCG8	Ensembl:ENSG00000143921	euGenes: HUgn64241
ECgene: ABCG8	H-InvDB: ABCG8

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=ABCG8

Licensable Technologies for ABCG8
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ABCG8:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ABCG8-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ABCG8		Antibodies for ABCG8
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ABCG8		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Search for Antibodies
	Chimera RNAi (ABCG8)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (ABCG8)
	Antibodies (ABCG8)

Search OriGene for ABCG8

Search Tocris compounds for ABCG8

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ABCG8

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ABCG8 Gene at Home site.
Version 2.41.1
server4.xennexinc.com

ABCG8 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for ABCG8

Summaries
for ABCG8

Genomic Location
for ABCG8

Proteins
for ABCG8

Protein Domains/
Families
for ABCG8

Gene Function
for ABCG8

Pathways & Interactions
for ABCG8

Drugs & Compounds
for ABCG8

Transcripts
for ABCG8

Expression
for ABCG8

Orthologs
for ABCG8

Paralogs
for ABCG8

SNPs/Variants
for ABCG8

Disorders & Mutations
for ABCG8

Medical News
for ABCG8

Publications
for ABCG8

Search for ABCG8

Genome Databases showing ABCG8

Other Databases showing ABCG8

Specialized Databases showing ABCG8

Licensable Technologies
for ABCG8

Services
for ABCG8

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ABCG8 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor ABCG8

Summariesfor ABCG8

Genomic Locationfor ABCG8

Proteinsfor ABCG8

Protein Domains/Familiesfor ABCG8

Gene Functionfor ABCG8

Pathways & Interactionsfor ABCG8

Drugs & Compoundsfor ABCG8

Transcriptsfor ABCG8

Expression for ABCG8

Orthologsfor ABCG8

Paralogsfor ABCG8

SNPs/Variantsfor ABCG8

Disorders & Mutationsfor ABCG8

Medical Newsfor ABCG8

Publicationsfor ABCG8

Search for ABCG8

Genome Databases showing ABCG8

Other Databases showing ABCG8

Specialized Databases showing ABCG8

Licensable Technologiesfor ABCG8

Servicesfor ABCG8

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ABCG8

Summaries
for ABCG8

Genomic Location
for ABCG8

Proteins
for ABCG8

Protein Domains/
Families
for ABCG8

Gene Function
for ABCG8

Pathways & Interactions
for ABCG8

Drugs & Compounds
for ABCG8

Transcripts
for ABCG8

Expression
for ABCG8

Orthologs
for ABCG8

Paralogs
for ABCG8

SNPs/Variants
for ABCG8

Disorders & Mutations
for ABCG8

Medical News
for ABCG8

Publications
for ABCG8

Licensable Technologies
for ABCG8

Services
for ABCG8